                         SEQUENCE LISTING

<110>  EpicentRx, Inc.
 
<120>  MULTIPLE TRANSGENE RECOMBINANT ADENOVIRUS

<130>  RDX-027PC2

<150>  US62/452,342
<151>  2017-01-30

<150>  US62/520,945
<151>  2017-06-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  DNA
<213>  Adenovirus type 5

<400>  1
ctgacctc                                                                 8


<210>  2
<211>  8
<212>  DNA
<213>  Adenovirus type 5

<400>  2
tcaccagg                                                                 8


<210>  3
<211>  8
<212>  DNA
<213>  Adenovirus type 5

<400>  3
cagtatga                                                                 8


<210>  4
<211>  10
<212>  DNA
<213>  Adenovirus type 5

<400>  4
taataaaaaa                                                              10


<210>  5
<211>  866
<212>  DNA
<213>  Homo sapiens

<400>  5
atgggccaca cacggaggca gggaacatca ccatccaagt gtccatacct caatttcttt       60

cagctcttgg tgctggctgg tctttctcac ttctgttcag gtgttatcca cgtgaccaag      120

gaagtgaaag aagtggcaac gctgtcctgt ggtcacaatg tttctgttga agagctggca      180

caaactcgca tctactggca aaaggagaag aaaatggtgc tgactatgat gtctggggac      240

atgaatatat ggcccgagta caagaaccgg accatctttg atatcactaa taacctctcc      300

attgtgatcc tggctctgcg cccatctgac gagggcacat acgagtgtgt tgttctgaag      360

tatgaaaaag acgctttcaa gcgggaacac ctggctgaag tgacgttatc agtcaaagct      420

gacttcccta cacctagtat atctgacttt gaaattccaa cttctaatat tagaaggata      480

atttgctcaa cctctggagg ttttccagag cctcacctct cctggttgga aaatggagaa      540

gaattaaatg ccatcaacac aacagtttcc caagatcctg aaactgagct ctatgctgtt      600

agcagcaaac tggatttcaa tatgacaacc aaccacagct tcatgtgtct catcaagtat      660

ggacatttaa gagtgaatca gaccttcaac tggaatacaa ccaagcaaga gcattttcct      720

gataacctgc tcccatcctg ggccattacc ttaatctcag taaatggaat ttttgtgata      780

tgctgcctga cctactgctt tgccccaaga tgcagagaga gaaggaggaa tgagagattg      840

agaagggaaa gtgtacgccc tgtata                                           866


<210>  6
<211>  895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD80 cloned into modified E1b-19k region with flanking 
       adenoviral sequences

<400>  6
ctgacctcgt cgacatgggc cacacacgga ggcagggaac atcaccatcc aagtgtccat       60

acctcaattt ctttcagctc ttggtgctgg ctggtctttc tcacttctgt tcaggtgtta      120

tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac aatgtttctg      180

ttgaagagct ggcacaaact cgcatctact ggcaaaagga gaagaaaatg gtgctgacta      240

tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc tttgatatca      300

ctaataacct ctccattgtg atcctggctc tgcgcccatc tgacgagggc acatacgagt      360

gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct gaagtgacgt      420

tatcagtcaa agctgacttc cctacaccta gtatatctga ctttgaaatt ccaacttcta      480

atattagaag gataatttgc tcaacctctg gaggttttcc agagcctcac ctctcctggt      540

tggaaaatgg agaagaatta aatgccatca acacaacagt ttcccaagat cctgaaactg      600

agctctatgc tgttagcagc aaactggatt tcaatatgac aaccaaccac agcttcatgt      660

gtctcatcaa gtatggacat ttaagagtga atcagacctt caactggaat acaaccaagc      720

aagagcattt tcctgataac ctgctcccat cctgggccat taccttaatc tcagtaaatg      780

gaatttttgt gatatgctgc ctgacctact gctttgcccc aagatgcaga gagagaagga      840

ggaatgagag attgagaagg gaaagtgtac gccctgtata actcgagtca ccagg           895


<210>  7
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  7
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc tgcacctcgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct cctgctcctg      120

ctcgctgctg catgcgctgt atttcttgca tgcccatggg ctgtgtctgg ggctcgcgca      180

tcacctggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aataa                      765


<210>  8
<211>  986
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137L cloned into modified E3 region with flanking 
       adenoviral sequences

<400>  8
cagtatgatt aaatgagaca tggaccagca cacacttgat gtggaggata ccgcggatgc       60

cagacatcca gcaggtactt cgtgcccctc ggatgcggcg ctcctcagag ataccgggct      120

cctcgcggac gctgcgctcc tctcagatac tgtgcgcccc acaaatgccg cgctccccac      180

ggatgctgcc taccctgcgg ttaatgttcg ggatcgcgag gccgcgtggc cgcctgcact      240

gaacttctgt tcccgccacc caaagctcta tggcctagtc gctttggttt tgctgcttct      300

gatcgccgcc tgtgttccta tcttcacccg caccgagcct cggccagcgc tcacaatcac      360

cacctcgccc aacctgggta cccgagagaa taatgcagac caggtcaccc ctgtttccca      420

cattggctgc cccaacacta cacaacaggg ctctcctgtg ttcgccaagc tactggctaa      480

aaaccaagca tcgttgtgca atacaactct gaactggcac agccaagatg gagctgggag      540

ctcataccta tctcaaggtc tgaggtacga agaagacaaa aaggagttgg tggtagacag      600

tcccgggctc tactacgtat ttttggaact gaagctcagt ccaacattca caaacacagg      660

ccacaaggtg cagggctggg tctctcttgt tttgcaagca aagcctcagg tagatgactt      720

tgacaacttg gccctgacag tggaactgtt cccttgctcc atggagaaca agttagtgga      780

ccgttcctgg agtcaactgt tgctcctgaa ggctggccac cgcctcagtg tgggtctgag      840

ggcttatctg catggagccc aggatgcata cagagactgg gagctgtctt atcccaacac      900

caccagcttt ggactctttc ttgtgaaacc cgacaaccca tgggaatgag gtctcaaaga      960

tcttattccc tttaactaat aaaaaa                                           986


<210>  9
<211>  4271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD80 - EMCV IRES - CD137L - FMDV IRES - ICAM cloned into 
       modified E1b-19k region with flanking adenoviral sequences

<400>  9
ctgacctcgt cgacatgggc cacacacgga ggcagggaac atcaccatcc aagtgtccat       60

acctcaattt ctttcagctc ttggtgctgg ctggtctttc tcacttctgt tcaggtgtta      120

tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac aatgtttctg      180

ttgaagagct ggcacaaact cgcatctact ggcaaaagga gaagaaaatg gtgctgacta      240

tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc tttgatatca      300

ctaataacct ctccattgtg atcctggctc tgcgcccatc tgacgagggc acatacgagt      360

gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct gaagtgacgt      420

tatcagtcaa agctgacttc cctacaccta gtatatctga ctttgaaatt ccaacttcta      480

atattagaag gataatttgc tcaacctctg gaggttttcc agagcctcac ctctcctggt      540

tggaaaatgg agaagaatta aatgccatca acacaacagt ttcccaagat cctgaaactg      600

agctctatgc tgttagcagc aaactggatt tcaatatgac aaccaaccac agcttcatgt      660

gtctcatcaa gtatggacat ttaagagtga atcagacctt caactggaat acaaccaagc      720

aagagcattt tcctgataac ctgctcccat cctgggccat taccttaatc tcagtaaatg      780

gaatttttgt gatatgctgc ctgacctact gctttgcccc aagatgcaga gagagaagga      840

ggaatgagag attgagaagg gaaagtgtac gccctgtata ataacgttac tggccgaagc      900

cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct      960

tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt     1020

ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct     1080

ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc     1140

ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag     1200

gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc     1260

tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga     1320

tctgatctgg ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc     1380

taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga taatatggaa     1440

tacgcctctg acgcttcact ggaccccgaa gccccgtggc ctcctgcacc tcgcgctcgc     1500

gcctgccgcg tactgccttg ggccctggtc gcggggctgc tgctcctgct cctgctcgct     1560

gctgcatgcg ctgtatttct tgcatgccca tgggctgtgt ctggggctcg cgcatcacct     1620

ggctccgcgg ccagcccgag actccgcgag ggtcccgagc tttcgcccga cgatcccgcc     1680

ggcctcttgg acctgcggca gggcatgttt gcgcagctgg tggcccaaaa tgttctgctg     1740

atcgatgggc ccctgagctg gtacagtgac ccaggcctgg caggcgtgtc cctgacgggg     1800

ggcctgagct acaaagagga cacgaaggag ctggtggtgg ccaaggctgg agtctactat     1860

gtcttctttc aactagagct gcggcgcgtg gtggccggcg agggctcagg ctccgtttca     1920

cttgcgctgc acctgcagcc actgcgctct gctgctgggg ccgccgccct ggctttgacc     1980

gtggacctgc cacccgcctc ctccgaggct cggaactcgg ccttcggttt ccagggccgc     2040

ttgctgcacc tgagtgccgg ccagcgcctg ggcgtccatc ttcacactga ggccagggca     2100

cgccatgcct ggcagcttac ccagggcgcc acagtcttgg gactcttccg ggtgaccccc     2160

gaaatcccag ccggactccc ttcaccgagg tcggaataag gtttccacaa ctgataaaac     2220

tcgtgcaact tgaaactccg cctggtcttt ccaggtctag aggggttaca ctttgtactg     2280

tgctcgactc cacgcccggt ccactggcgg gtgttagtag cagcactgtt gtttcgtagc     2340

ggagcatggt ggccgtggga actcctcctt ggtgacaagg gcccacgggg ccgaaagcca     2400

cgtccagacg gacccaccat gtgtgcaacc ccagcacggc aacttttact gcgaacacca     2460

ccttaaggtg acactggtac tggtactcgg tcactggtga caggctaagg atgcccttca     2520

ggtaccccga ggtaacacgg gacactcggg atctgagaag gggattggga cttctttaaa     2580

agtgcccagt ttaaaaagct tctacgcctg aataggcgac cggaggccgg cgcctttcca     2640

ttacccacta ctaaatccat ggctcccagc agcccccggc ccgcgctgcc cgcactcctg     2700

gtcctgctcg gggctctgtt cccaggacct ggcaatgccc agacatctgt gtccccctca     2760

aaagtcatcc tgccccgggg aggctccgtg ctggtgacat gcagcacctc ctgtgaccag     2820

cccaagttgt tgggcataga gaccccgttg cctaaaaagg agttgctcct gcctgggaac     2880

aaccggaagg tgtatgaact gagcaatgtg caagaagata gccaaccaat gtgctattca     2940

aactgccctg atgggcagtc aacagctaaa accttcctca ccgtgtactg gactccagaa     3000

cgggtggaac tggcacccct cccctcttgg cagccagtgg gcaagaacct taccctacgc     3060

tgccaggtgg agggtggggc accccgggcc aacctcaccg tggtgctgct ccgtggggag     3120

aaggagctga aacgggagcc agctgtgggg gagcccgctg aggtcacgac cacggtgctg     3180

gtgaggagag atcaccatgg agccaatttc tcgtgccgca ctgaactgga cctgcggccc     3240

caagggctgg agctgtttga gaacacctcg gccccctacc agctccagac ctttgtcctg     3300

ccagcgactc ccccacaact tgtcagcccc cgggtcctag aggtggacac gcaggggacc     3360

gtggtctgtt ccctggacgg gctgttccca gtctcggagg cccaggtcca cctggcactg     3420

ggggaccaga ggttgaaccc cacagtcacc tatggcaacg actccttctc ggccaaggcc     3480

tcagtcagtg tgaccgcaga ggacgagggc acccagcggc tgacgtgtgc agtaatactg     3540

gggaaccaga gccaggagac actgcagaca gtgaccatct acagctttcc ggcgcccaac     3600

gtgattctga cgaagccaga ggtctcagaa gggaccgagg tgacagtgaa gtgtgaggcc     3660

caccctagag ccaaggtgac gctgaatggg gttccagccc agccactggg cccgagggcc     3720

cagctcctgc tgaaggccac cccagaggac aacgggcgca gcttctcctg ctctgcaacc     3780

ctggaggtgg ccggccagct tatacacaag aaccagaccc gggagcttcg tgtcctgtat     3840

ggcccccgac tggacgagag ggattgtccg ggaaactgga cgtggccaga aaattcccag     3900

cagactccaa tgtgccaggc ttgggggaac ccattgcccg agctcaagtg tctaaaggat     3960

ggcactttcc cactgcccat cggggaatca gtgactgtca ctcgagatct tgagggcacc     4020

tacctctgtc gggccaggag cactcaaggg gaggtcaccc gcaaggtgac cgtgaatgtg     4080

ctctcccccc ggtatgagat tgtcatcatc actgtggtag cagccgcagt cataatgggc     4140

actgcaggcc tcagcacgta cctctataac cgccagcgga agatcaagaa atacagacta     4200

caacaggccc aaaaagggac ccccatgaaa ccgaacacac aagccacgcc tccctgactc     4260

gagtcaccag g                                                          4271


<210>  10
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  10
atgtgtcacc agcagttggt catctcttgg ttttccctgg tttttctggc atctcccctc       60

gtggccatat gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatccggat      120

gcccctggag aaatggtggt cctcacctgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaaa ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgatatttt aaaggaccag      360

aaagaaccca aaaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactctctgc agagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agccattaaa gaattctcgg caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg cagttagtaa                                       990


<210>  11
<211>  2669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human endostatin - IRES - angiostatin cloned into modified 
       E1b-19k region with flanking adenoviral sequences

<400>  11
ctgacctcgt cgacatggct ccctacccct gtggctgcca catcctgctg ctgctcttct       60

gctgcctggc ggctgcccgg gccagctcct acgtgcacct gcggccggcg cgacccacaa      120

gcccacccgc ccacagccac cgcgacttcc agccggtgct ccacctggtt gcgctcaaca      180

gccccctgtc aggcggcatg cggggcatcc gcggggccga cttccagtgc ttccagcagg      240

cgcgggccgt ggggctggcg ggcaccttcc gcgccttcct gtcctcgcgc ctgcaggacc      300

tgtacagcat cgtgcgccgt gccgaccgcg cagccgtgcc catcgtcaac ctcaaggacg      360

agctgctgtt tcccagctgg gaggctctgt tctcaggctc tgagggtccg ctgaagcccg      420

gggcacgcat cttctccttt gacggcaagg acgtcctgag gcaccccacc tggccccaga      480

agagcgtgtg gcatggctcg gaccccaacg ggcgcaggct gaccgagagc tactgtgaga      540

cgtggcggac ggaggctccc tcggccacgg gccaggcctc ctcgctgctg gggggcaggc      600

tcctggggca gagtgccgcg agctgccatc acgcctacat cgtgctctgc attgagaaca      660

gcttcatgac tgcctccaag tagtaacgtt actggccgaa gccgcttgga ataaggccgg      720

tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc      780

cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa      840

ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga      900

caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc      960

ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc     1020

cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac     1080

aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg     1140

tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg     1200

gggacgtggt tttcctttga aaaacacgat gataatatgg aacataagga agtggttctt     1260

ctacttcttt tatttctgaa atcaggtcaa ggaaaagtgt atctctcaga gtgcaagact     1320

gggaatggaa agaactacag agggacgatg tccaaaacaa aaaatggcat cacctgtcaa     1380

aaatggagtt ccacttctcc ccacagacct agattctcac ctgctacaca cccctcagag     1440

ggactggagg agaactactg caggaatcca gacaacgatc cgcaggggcc ctggtgctat     1500

actactgatc cagaaaagag atatgactac tgcgacattc ttgagtgtga agaggaatgt     1560

atgcattgca gtggagaaaa ctatgacggc aaaatttcca agaccatgtc tggactggaa     1620

tgccaggcct gggactctca gagcccacac gctcatggat acattccttc caaatttcca     1680

aacaagaacc tgaagaagaa ttactgtcgt aaccccgata gggagctgcg gccttggtgt     1740

ttcaccaccg accccaacaa gcgctgggaa ctttgtgaca tcccccgctg cacaacacct     1800

ccaccatctt ctggtcccac ctaccagtgt ctgaagggaa caggtgaaaa ctatcgcggg     1860

aatgtggctg ttaccgtgtc cgggcacacc tgtcagcact ggagtgcaca gacccctcac     1920

acacataaca ggacaccaga aaacttcccc tgcaaaaatt tggatgaaaa ctactgccgc     1980

aatcctgacg gaaaaagggc cccatggtgc catacaacca acagccaagt gcggtgggag     2040

tactgtaaga taccgtcctg tgactcctcc ccagtatcca cggaacaatt ggctcccaca     2100

gcaccacctg agctaacccc tgtggtccag gactgctacc atggtgatgg acagagctac     2160

cgaggcacat cctccaccac caccacagga aagaagtgtc agtcttggtc atctatgaca     2220

ccacaccggc accagaagac cccagaaaac tacccaaatg ctggcctgac aatgaactac     2280

tgcaggaatc cagatgccga taaaggcccc tggtgtttta ccacagaccc cagcgtcagg     2340

tgggagtact gcaacctgaa aaaatgctca ggaacagaag cgagtgttgt agcacctccg     2400

cctgttgtcc tgcttccaga tgtagagact ccttccgaag aagactgtat gtttgggaat     2460

gggaaaggat accgaggcaa gagggcgacc actgttactg ggacgccatg ccaggactgg     2520

gctgcccagg agccccatag acacagcatt ttcactccag agacaaatcc acgggcgggt     2580

ctggaaaaaa attactgccg taaccctgat ggtgatgtag gtggtccctg gtgctacacg     2640

acaaatccaa gatagctcga gtcaccagg                                       2669


<210>  12
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  12
atgctgggga gcagagctgt aatgctgctg ttgctgctgc cctggacagc tcagggcaga       60

gctgtgcctg ggggcagcag ccctgcctgg actcagtgcc agcagctttc acagaagctc      120

tgcacactgg cctggagtgc acatccacta gtgggacaca tggatctaag agaagaggga      180

gatgaagaga ctacaaatga tgttccccat atccagtgtg gagatggctg tgacccccaa      240

ggactcaggg acaacagtca gttctgcttg caaaggatcc accagggtct gattttttat      300

gagaagctgc taggatcgga tattttcaca ggggagcctt ctctgctccc tgatagccct      360

gtgggccagc ttcatgcctc cctactgggc ctcagccaac tcctgcagcc tgagggtcac      420

cactgggaga ctcagcagat tccaagcctc agtcccagcc agccatggca gcgtctcctt      480

ctccgcttca aaatccttcg cagcctccag gcctttgtgg ctgtagccgc ccgggtcttt      540

gcccatggag cagcaaccct gagtccctaa                                       570


<210>  13
<211>  2141
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human IL-23A - IRES - p40 cloned into modified E1b-19k region 
       with flanking adenoviral sequences

<400>  13
ctgacctcgt cgacatgctg gggagcagag ctgtaatgct gctgttgctg ctgccctgga       60

cagctcaggg cagagctgtg cctgggggca gcagccctgc ctggactcag tgccagcagc      120

tttcacagaa gctctgcaca ctggcctgga gtgcacatcc actagtggga cacatggatc      180

taagagaaga gggagatgaa gagactacaa atgatgttcc ccatatccag tgtggagatg      240

gctgtgaccc ccaaggactc agggacaaca gtcagttctg cttgcaaagg atccaccagg      300

gtctgatttt ttatgagaag ctgctaggat cggatatttt cacaggggag ccttctctgc      360

tccctgatag ccctgtgggc cagcttcatg cctccctact gggcctcagc caactcctgc      420

agcctgaggg tcaccactgg gagactcagc agattccaag cctcagtccc agccagccat      480

ggcagcgtct ccttctccgc ttcaaaatcc ttcgcagcct ccaggccttt gtggctgtag      540

ccgcccgggt ctttgcccat ggagcagcaa ccctgagtcc ctaataacgt tactggccga      600

agccgcttgg aataaggccg gtgtgcgttt gtctatatgt tattttccac catattgccg      660

tcttttggca atgtgagggc ccggaaacct ggccctgtct tcttgacgag cattcctagg      720

ggtctttccc ctctcgccaa aggaatgcaa ggtctgttga atgtcgtgaa ggaagcagtt      780

cctctggaag cttcttgaag acaaacaacg tctgtagcga ccctttgcag gcagcggaac      840

cccccacctg gcgacaggtg cctctgcggc caaaagccac gtgtataaga tacacctgca      900

aaggcggcac aaccccagtg ccacgttgtg agttggatag ttgtggaaag agtcaaatgg      960

ctctcctcaa gcgtattcaa caaggggctg aaggatgccc agaaggtacc ccattgtatg     1020

ggatctgatc tggggcctcg gtgcacatgc tttacatgtg tttagtcgag gttaaaaaac     1080

gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga tgataatatg     1140

tgtcaccagc agttggtcat ctcttggttt tccctggttt ttctggcatc tcccctcgtg     1200

gccatatggg aactgaagaa agatgtttat gtcgtagaat tggattggta tccggatgcc     1260

cctggagaaa tggtggtcct cacctgtgac acccctgaag aagatggtat cacctggacc     1320

ttggaccaga gcagtgaggt cttaggctct ggcaaaaccc tgaccatcca agtcaaagag     1380

tttggagatg ctggccagta cacctgtcac aaaggaggcg aggttctaag ccattcgctc     1440

ctgctgcttc acaaaaagga agatggaatt tggtccactg atattttaaa ggaccagaaa     1500

gaacccaaaa ataagacctt tctaagatgc gaggccaaga attattctgg acgtttcacc     1560

tgctggtggc tgacgacaat cagtactgat ttgacattca gtgtcaaaag cagcagaggc     1620

tcttctgacc cccaaggggt gacgtgcgga gctgctacac tctctgcaga gagagtcaga     1680

ggggacaaca aggagtatga gtactcagtg gagtgccagg aggacagtgc ctgcccagct     1740

gctgaggaga gtctgcccat tgaggtcatg gtggatgccg ttcacaagct caagtatgaa     1800

aactacacca gcagcttctt catcagggac atcatcaaac ctgacccacc caagaacttg     1860

cagctgaagc cattaaagaa ttctcggcag gtggaggtca gctgggagta ccctgacacc     1920

tggagtactc cacattccta cttctccctg acattctgcg ttcaggtcca gggcaagagc     1980

aagagagaaa agaaagatag agtcttcacg gacaagacct cagccacggt catctgccgc     2040

aaaaatgcca gcattagcgt gcgggcccag gaccgctact atagctcatc ttggagcgaa     2100

tgggcatctg tgccctgcag ttagtaactc gagtcaccag g                         2141


<210>  14
<211>  36808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adenovirus with human CD80 - IRES - CD137L cloned into modified 
       E1b-19k region

<400>  14
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgttttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg      240

aataagagga agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta      300

gggccgcggg gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt      360

ttccgcgttc cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat      420

ttatacccgg tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc      480

tccgagccgc tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta      540

ttaccgaaga aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata      600

atcttccacc tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg      660

tgacggcccc cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa      720

tgttggcggt gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg      780

agccgcctca cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt      840

ctatgccaaa ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac      900

ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg      960

ggcacggttg caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt     1020

gttcgctttg ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg     1080

cagtgggtga tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt     1140

gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc     1200

tgagcccgag ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc     1260

tatcctgaga cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg     1320

tgactccggt ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat     1380

taaaccagtt gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt     1440

gcttaacgag cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt     1500

aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt     1560

aataaagggt gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg     1620

gtatataatg cgccgtgggc taatcttggt tacatctgac ctcgtcgaca tgggccacac     1680

acggaggcag ggaacatcac catccaagtg tccatacctc aatttctttc agctcttggt     1740

gctggctggt ctttctcact tctgttcagg tgttatccac gtgaccaagg aagtgaaaga     1800

agtggcaacg ctgtcctgtg gtcacaatgt ttctgttgaa gagctggcac aaactcgcat     1860

ctactggcaa aaggagaaga aaatggtgct gactatgatg tctggggaca tgaatatatg     1920

gcccgagtac aagaaccgga ccatctttga tatcactaat aacctctcca ttgtgatcct     1980

ggctctgcgc ccatctgacg agggcacata cgagtgtgtt gttctgaagt atgaaaaaga     2040

cgctttcaag cgggaacacc tggctgaagt gacgttatca gtcaaagctg acttccctac     2100

acctagtata tctgactttg aaattccaac ttctaatatt agaaggataa tttgctcaac     2160

ctctggaggt tttccagagc ctcacctctc ctggttggaa aatggagaag aattaaatgc     2220

catcaacaca acagtttccc aagatcctga aactgagctc tatgctgtta gcagcaaact     2280

ggatttcaat atgacaacca accacagctt catgtgtctc atcaagtatg gacatttaag     2340

agtgaatcag accttcaact ggaatacaac caagcaagag cattttcctg ataacctgct     2400

cccatcctgg gccattacct taatctcagt aaatggaatt tttgtgatat gctgcctgac     2460

ctactgcttt gccccaagat gcagagagag aaggaggaat gagagattga gaagggaaag     2520

tgtacgccct gtataataac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt     2580

ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac     2640

ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc     2700

aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa     2760

cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg     2820

gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg     2880

tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc     2940

tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat     3000

gctttacatg tgtttagtcg aggttaaaaa acgtctaggc cccccgaacc acggggacgt     3060

ggttttcctt tgaaaaacac gatgataata tggaatacgc ctctgacgct tcactggacc     3120

ccgaagcccc gtggcctcct gcacctcgcg ctcgcgcctg ccgcgtactg ccttgggccc     3180

tggtcgcggg gctgctgctc ctgctcctgc tcgctgctgc atgcgctgta tttcttgcat     3240

gcccatgggc tgtgtctggg gctcgcgcat cacctggctc cgcggccagc ccgagactcc     3300

gcgagggtcc cgagctttcg cccgacgatc ccgccggcct cttggacctg cggcagggca     3360

tgtttgcgca gctggtggcc caaaatgttc tgctgatcga tgggcccctg agctggtaca     3420

gtgacccagg cctggcaggc gtgtccctga cggggggcct gagctacaaa gaggacacga     3480

aggagctggt ggtggccaag gctggagtct actatgtctt ctttcaacta gagctgcggc     3540

gcgtggtggc cggcgagggc tcaggctccg tttcacttgc gctgcacctg cagccactgc     3600

gctctgctgc tggggccgcc gccctggctt tgaccgtgga cctgccaccc gcctcctccg     3660

aggctcggaa ctcggccttc ggtttccagg gccgcttgct gcacctgagt gccggccagc     3720

gcctgggcgt ccatcttcac actgaggcca gggcacgcca tgcctggcag cttacccagg     3780

gcgccacagt cttgggactc ttccgggtga cccccgaaat cccagccgga ctcccttcac     3840

cgaggtcgga ataactcgag tcaccaggcg cttttccaag agaaggtcat caagactttg     3900

gatttttcca caccggggcg cgctgcggct gctgttgctt ttttgagttt tataaaggat     3960

aaatggagcg aagaaaccca tctgagcggg gggtaccctg ctggattttc tggccatgca     4020

tctgtggaga gcggttgtga gacacaagaa tcgcctgcta ctgttgtctt ccgtccgccc     4080

ggcgataata ccgacggagg agcagcagca gcagcaggag gaagccaggc ggcggcggca     4140

ggagcagagc ccatggaacc cgagagccgg cctggaccct cgggaatgaa tgttgtacag     4200

gtggctgaac tgtatccaga actgagacgc attttgacaa ttacagagga tgggcagggg     4260

ctaaaggggg taaagaggga gcggggggct tgtgaggcta cagaggaggc taggaatcta     4320

gcttttagct taatgaccag acaccgtcct gagtgtatta cttttcaaca gatcaaggat     4380

aattgcgcta atgagcttga tctgctggcg cagaagtatt ccatagagca gctgaccact     4440

tactggctgc agccagggga tgattttgag gaggctatta gggtatatgc aaaggtggca     4500

cttaggccag attgcaagta caagatcagc aaacttgtaa atatcaggaa ttgttgctac     4560

atttctggga acggggccga ggtggagata gatacggagg atagggtggc ctttagatgt     4620

agcatgataa atatgtggcc gggggtgctt ggcatggacg gggtggttat tatgaatgta     4680

aggtttactg gccccaattt tagcggtacg gttttcctgg ccaataccaa ccttatccta     4740

cacggtgtaa gcttctatgg gtttaacaat acctgtgtgg aagcctggac cgatgtaagg     4800

gttcggggct gtgcctttta ctgctgctgg aagggggtgg tgtgtcgccc caaaagcagg     4860

gcttcaatta agaaatgcct ctttgaaagg tgtaccttgg gtatcctgtc tgagggtaac     4920

tccagggtgc gccacaatgt ggcctccgac tgtggttgct tcatgctagt gaaaagcgtg     4980

gctgtgatta agcataacat ggtatgtggc aactgcgagg acagggcctc tcagatgctg     5040

acctgctcgg acggcaactg tcacctgctg aagaccattc acgtagccag ccactctcgc     5100

aaggcctggc cagtgtttga gcataacata ctgacccgct gttccttgca tttgggtaac     5160

aggagggggg tgttcctacc ttaccaatgc aatttgagtc acactaagat attgcttgag     5220

cccgagagca tgtccaaggt gaacctgaac ggggtgtttg acatgaccat gaagatctgg     5280

aaggtgctga ggtacgatga gacccgcacc aggtgcagac cctgcgagtg tggcggtaaa     5340

catattagga accagcctgt gatgctggat gtgaccgagg agctgaggcc cgatcacttg     5400

gtgctggcct gcacccgcgc tgagtttggc tctagcgatg aagatacaga ttgaggtact     5460

gaaatgtgtg ggcgtggctt aagggtggga aagaatatat aaggtggggg tcttatgtag     5520

ttttgtatct gttttgcagc agccgccgcc gccatgagca ccaactcgtt tgatggaagc     5580

attgtgagct catatttgac aacgcgcatg cccccatggg ccggggtgcg tcagaatgtg     5640

atgggctcca gcattgatgg tcgccccgtc ctgcccgcaa actctactac cttgacctac     5700

gagaccgtgt ctggaacgcc gttggagact gcagcctccg ccgccgcttc agccgctgca     5760

gccaccgccc gcgggattgt gactgacttt gctttcctga gcccgcttgc aagcagtgca     5820

gcttcccgtt catccgcccg cgatgacaag ttgacggctc ttttggcaca attggattct     5880

ttgacccggg aacttaatgt cgtttctcag cagctgttgg atctgcgcca gcaggtttct     5940

gccctgaagg cttcctcccc tcccaatgcg gtttaaaaca taaataaaaa accagactct     6000

gtttggattt ggatcaagca agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg     6060

taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg     6120

taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag     6180

caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag     6240

cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc     6300

ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga     6360

tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc     6420

atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc     6480

ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg     6540

cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg     6600

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag     6660

cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta     6720

ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc     6780

ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc     6840

ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc     6900

aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta     6960

agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc     7020

agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta     7080

ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc     7140

tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt     7200

acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg     7260

tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca     7320

gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt     7380

cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg     7440

cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt     7500

agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc     7560

agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt     7620

ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct     7680

cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg     7740

gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc     7800

aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca     7860

ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt     7920

tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg     7980

cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt     8040

actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg     8100

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt     8160

cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg     8220

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg     8280

ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg     8340

tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa     8400

cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc     8460

gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg     8520

taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta     8580

gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc     8640

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg     8700

gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca     8760

cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg     8820

gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg     8880

gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg     8940

cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt     9000

agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc     9060

ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct     9120

ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct     9180

tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa     9240

aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc     9300

cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg     9360

tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg     9420

gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc     9480

cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag     9540

gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa     9600

gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca     9660

ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg     9720

gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg     9780

ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga     9840

agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga     9900

caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc     9960

aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact    10020

cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct    10080

gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc    10140

ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct    10200

cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg    10260

cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga    10320

gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca    10380

gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga    10440

tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg    10500

ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg    10560

tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg    10620

caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc    10680

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag    10740

ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc    10800

tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag    10860

atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag    10920

ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc    10980

ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac    11040

ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac    11100

gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag    11160

gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga    11220

cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg    11280

ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc    11340

ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg    11400

gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac    11460

ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg    11520

ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg    11580

ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa    11640

cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg    11700

cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa    11760

gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg    11820

ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt    11880

gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc    11940

atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc    12000

tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac    12060

gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc    12120

cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca    12180

gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct    12240

cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg    12300

cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc    12360

ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc    12420

ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa    12480

gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctaccg    12540

tgcaaaagga gagcctgtaa gcgggcactc ttccgtggtc tggtggataa attcgcaagg    12600

gtatcatggc ggacgaccgg ggttcgagcc ccgtatccgg ccgtccgccg tgatccatgc    12660

ggttaccgcc cgcgtgtcga acccaggtgt gcgacgtcag acaacggggg agtgctcctt    12720

ttggcttcct tccaggcgcg gcggctgctg cgctagcttt tttggccact ggccgcgcgc    12780

agcgtaagcg gttaggctgg aaagcgaaag cattaagtgg ctcgctccct gtagccggag    12840

ggttattttc caagggttga gtcgcgggac ccccggttcg agtctcggac cggccggact    12900

gcggcgaacg ggggtttgcc tccccgtcat gcaagacccc gcttgcaaat tcctccggaa    12960

acagggacga gccccttttt tgcttttccc agatgcatcc ggtgctgcgg cagatgcgcc    13020

cccctcctca gcagcggcaa gagcaagagc agcggcagac atgcagggca ccctcccctc    13080

ctcctaccgc gtcaggaggg gcgacatccg cggttgacgc ggcagcagat ggtgattacg    13140

aacccccgcg gcgccgggcc cggcactacc tggacttgga ggagggcgag ggcctggcgc    13200

ggctaggagc gccctctcct gagcggtacc caagggtgca gctgaagcgt gatacgcgtg    13260

aggcgtacgt gccgcggcag aacctgtttc gcgaccgcga gggagaggag cccgaggaga    13320

tgcgggatcg aaagttccac gcagggcgcg agctgcggca tggcctgaat cgcgagcggt    13380

tgctgcgcga ggaggacttt gagcccgacg cgcgaaccgg gattagtccc gcgcgcgcac    13440

acgtggcggc cgccgacctg gtaaccgcat acgagcagac ggtgaaccag gagattaact    13500

ttcaaaaaag ctttaacaac cacgtgcgta cgcttgtggc gcgcgaggag gtggctatag    13560

gactgatgca tctgtgggac tttgtaagcg cgctggagca aaacccaaat agcaagccgc    13620

tcatggcgca gctgttcctt atagtgcagc acagcaggga caacgaggca ttcagggatg    13680

cgctgctaaa catagtagag cccgagggcc gctggctgct cgatttgata aacatcctgc    13740

agagcatagt ggtgcaggag cgcagcttga gcctggctga caaggtggcc gccatcaact    13800

attccatgct tagcctgggc aagttttacg cccgcaagat ataccatacc ccttacgttc    13860

ccatagacaa ggaggtaaag atcgaggggt tctacatgcg catggcgctg aaggtgctta    13920

ccttgagcga cgacctgggc gtttatcgca acgagcgcat ccacaaggcc gtgagcgtga    13980

gccggcggcg cgagctcagc gaccgcgagc tgatgcacag cctgcaaagg gccctggctg    14040

gcacgggcag cggcgataga gaggccgagt cctactttga cgcgggcgct gacctgcgct    14100

gggccccaag ccgacgcgcc ctggaggcag ctggggccgg acctgggctg gcggtggcac    14160

ccgcgcgcgc tggcaacgtc ggcggcgtgg aggaatatga cgaggacgat gagtacgagc    14220

cagaggacgg cgagtactaa gcggtgatgt ttctgatcag atgatgcaag acgcaacgga    14280

cccggcggtg cgggcggcgc tgcagagcca gccgtccggc cttaactcca cggacgactg    14340

gcgccaggtc atggaccgca tcatgtcgct gactgcgcgc aatcctgacg cgttccggca    14400

gcagccgcag gccaaccggc tctccgcaat tctggaagcg gtggtcccgg cgcgcgcaaa    14460

ccccacgcac gagaaggtgc tggcgatcgt aaacgcgctg gccgaaaaca gggccatccg    14520

gcccgacgag gccggcctgg tctacgacgc gctgcttcag cgcgtggctc gttacaacag    14580

cggcaacgtg cagaccaacc tggaccggct ggtgggggat gtgcgcgagg ccgtggcgca    14640

gcgtgagcgc gcgcagcagc agggcaacct gggctccatg gttgcactaa acgccttcct    14700

gagtacacag cccgccaacg tgccgcgggg acaggaggac tacaccaact ttgtgagcgc    14760

actgcggcta atggtgactg agacaccgca aagtgaggtg taccagtctg ggccagacta    14820

ttttttccag accagtagac aaggcctgca gaccgtaaac ctgagccagg ctttcaaaaa    14880

cttgcagggg ctgtgggggg tgcgggctcc cacaggcgac cgcgcgaccg tgtctagctt    14940

gctgacgccc aactcgcgcc tgttgctgct gctaatagcg cccttcacgg acagtggcag    15000

cgtgtcccgg gacacatacc taggtcactt gctgacactg taccgcgagg ccataggtca    15060

ggcgcatgtg gacgagcata ctttccagga gattacaagt gtcagccgcg cgctggggca    15120

ggaggacacg ggcagcctgg aggcaaccct aaactacctg ctgaccaacc ggcggcagaa    15180

gatcccctcg ttgcacagtt taaacagcga ggaggagcgc attttgcgct acgtgcagca    15240

gagcgtgagc cttaacctga tgcgcgacgg ggtaacgccc agcgtggcgc tggacatgac    15300

cgcgcgcaac atggaaccgg gcatgtatgc ctcaaaccgg ccgtttatca accgcctaat    15360

ggactacttg catcgcgcgg ccgccgtgaa ccccgagtat ttcaccaatg ccatcttgaa    15420

cccgcactgg ctaccgcccc ctggtttcta caccggggga ttcgaggtgc ccgagggtaa    15480

cgatggattc ctctgggacg acatagacga cagcgtgttt tccccgcaac cgcagaccct    15540

gctagagttg caacagcgcg agcaggcaga ggcggcgctg cgaaaggaaa gcttccgcag    15600

gccaagcagc ttgtccgatc taggcgctgc ggccccgcgg tcagatgcta gtagcccatt    15660

tccaagcttg atagggtctc ttaccagcac tcgcaccacc cgcccgcgcc tgctgggcga    15720

ggaggagtac ctaaacaact cgctgctgca gccgcagcgc gaaaaaaacc tgcctccggc    15780

atttcccaac aacgggatag agagcctagt ggacaagatg agtagatgga agacgtacgc    15840

gcaggagcac agggacgtgc caggcccgcg cccgcccacc cgtcgtcaaa ggcacgaccg    15900

tcagcggggt ctggtgtggg aggacgatga ctcggcagac gacagcagcg tcctggattt    15960

gggagggagt ggcaacccgt ttgcgcacct tcgccccagg ctggggagaa tgttttaaaa    16020

aaaaaaaagc atgatgcaaa ataaaaaact caccaaggcc atggcaccga gcgttggttt    16080

tcttgtattc cccttagtat gcggcgcgcg gcgatgtatg aggaaggtcc tcctccctcc    16140

tacgagagtg tggtgagcgc ggcgccagtg gcggcggcgc tgggttctcc cttcgatgct    16200

cccctggacc cgccgtttgt gcctccgcgg tacctgcggc ctaccggggg gagaaacagc    16260

atccgttact ctgagttggc acccctattc gacaccaccc gtgtgtacct ggtggacaac    16320

aagtcaacgg atgtggcatc cctgaactac cagaacgacc acagcaactt tctgaccacg    16380

gtcattcaaa acaatgacta cagcccgggg gaggcaagca cacagaccat caatcttgac    16440

gaccggtcgc actggggcgg cgacctgaaa accatcctgc ataccaacat gccaaatgtg    16500

aacgagttca tgtttaccaa taagtttaag gcgcgggtga tggtgtcgcg cttgcctact    16560

aaggacaatc aggtggagct gaaatacgag tgggtggagt tcacgctgcc cgagggcaac    16620

tactccgaga ccatgaccat agaccttatg aacaacgcga tcgtggagca ctacttgaaa    16680

gtgggcagac agaacggggt tctggaaagc gacatcgggg taaagtttga cacccgcaac    16740

ttcagactgg ggtttgaccc cgtcactggt cttgtcatgc ctggggtata tacaaacgaa    16800

gccttccatc cagacatcat tttgctgcca ggatgcgggg tggacttcac ccacagccgc    16860

ctgagcaact tgttgggcat ccgcaagcgg caacccttcc aggagggctt taggatcacc    16920

tacgatgatc tggagggtgg taacattccc gcactgttgg atgtggacgc ctaccaggcg    16980

agcttgaaag atgacaccga acagggcggg ggtggcgcag gcggcagcaa cagcagtggc    17040

agcggcgcgg aagagaactc caacgcggca gccgcggcaa tgcagccggt ggaggacatg    17100

aacgatcatg ccattcgcgg cgacaccttt gccacacggg ctgaggagaa gcgcgctgag    17160

gccgaagcag cggccgaagc tgccgccccc gctgcgcaac ccgaggtcga gaagcctcag    17220

aagaaaccgg tgatcaaacc cctgacagag gacagcaaga aacgcagtta caacctaata    17280

agcaatgaca gcaccttcac ccagtaccgc agctggtacc ttgcatacaa ctacggcgac    17340

cctcagaccg gaatccgctc atggaccctg ctttgcactc ctgacgtaac ctgcggctcg    17400

gagcaggtct actggtcgtt gccagacatg atgcaagacc ccgtgacctt ccgctccacg    17460

cgccagatca gcaactttcc ggtggtgggc gccgagctgt tgcccgtgca ctccaagagc    17520

ttctacaacg accaggccgt ctactcccaa ctcatccgcc agtttacctc tctgacccac    17580

gtgttcaatc gctttcccga gaaccagatt ttggcgcgcc cgccagcccc caccatcacc    17640

accgtcagtg aaaacgttcc tgctctcaca gatcacggga cgctaccgct gcgcaacagc    17700

atcggaggag tccagcgagt gaccattact gacgccagac gccgcacctg cccctacgtt    17760

tacaaggccc tgggcatagt ctcgccgcgc gtcctatcga gccgcacttt ttgagcaagc    17820

atgtccatcc ttatatcgcc cagcaataac acaggctggg gcctgcgctt cccaagcaag    17880

atgtttggcg gggccaagaa gcgctccgac caacacccag tgcgcgtgcg cgggcactac    17940

cgcgcgccct ggggcgcgca caaacgcggc cgcactgggc gcaccaccgt cgatgacgcc    18000

atcgacgcgg tggtggagga ggcgcgcaac tacacgccca cgccgccacc agtgtccaca    18060

gtggacgcgg ccattcagac cgtggtgcgc ggagcccggc gctatgctaa aatgaagaga    18120

cggcggaggc gcgtagcacg tcgccaccgc cgccgacccg gcactgccgc ccaacgcgcg    18180

gcggcggccc tgcttaaccg cgcacgtcgc accggccgac gggcggccat gcgggccgct    18240

cgaaggctgg ccgcgggtat tgtcactgtg ccccccaggt ccaggcgacg agcggccgcc    18300

gcagcagccg cggccattag tgctatgact cagggtcgca ggggcaacgt gtattgggtg    18360

cgcgactcgg ttagcggcct gcgcgtgccc gtgcgcaccc gccccccgcg caactagatt    18420

gcaagaaaaa actacttaga ctcgtactgt tgtatgtatc cagcggcggc ggcgcgcaac    18480

gaagctatgt ccaagcgcaa aatcaaagaa gagatgctcc aggtcatcgc gccggagatc    18540

tatggccccc cgaagaagga agagcaggat tacaagcccc gaaagctaaa gcgggtcaaa    18600

aagaaaaaga aagatgatga tgatgaactt gacgacgagg tggaactgct gcacgctacc    18660

gcgcccaggc gacgggtaca gtggaaaggt cgacgcgtaa aacgtgtttt gcgacccggc    18720

accaccgtag tctttacgcc cggtgagcgc tccacccgca cctacaagcg cgtgtatgat    18780

gaggtgtacg gcgacgagga cctgcttgag caggccaacg agcgcctcgg ggagtttgcc    18840

tacggaaagc ggcataagga catgctggcg ttgccgctgg acgagggcaa cccaacacct    18900

agcctaaagc ccgtaacact gcagcaggtg ctgcccgcgc ttgcaccgtc cgaagaaaag    18960

cgcggcctaa agcgcgagtc tggtgacttg gcacccaccg tgcagctgat ggtacccaag    19020

cgccagcgac tggaagatgt cttggaaaaa atgaccgtgg aacctgggct ggagcccgag    19080

gtccgcgtgc ggccaatcaa gcaggtggcg ccgggactgg gcgtgcagac cgtggacgtt    19140

cagataccca ctaccagtag caccagtatt gccaccgcca cagagggcat ggagacacaa    19200

acgtccccgg ttgcctcagc ggtggcggat gccgcggtgc aggcggtcgc tgcggccgcg    19260

tccaagacct ctacggaggt gcaaacggac ccgtggatgt ttcgcgtttc agccccccgg    19320

cgcccgcgcg gttcgaggaa gtacggcgcc gccagcgcgc tactgcccga atatgcccta    19380

catccttcca ttgcgcctac ccccggctat cgtggctaca cctaccgccc cagaagacga    19440

gcaactaccc gacgccgaac caccactgga acccgccgcc gccgtcgccg tcgccagccc    19500

gtgctggccc cgatttccgt gcgcagggtg gctcgcgaag gaggcaggac cctggtgctg    19560

ccaacagcgc gctaccaccc cagcatcgtt taaaagccgg tctttgtggt tcttgcagat    19620

atggccctca cctgccgcct ccgtttcccg gtgccgggat tccgaggaag aatgcaccgt    19680

aggaggggca tggccggcca cggcctgacg ggcggcatgc gtcgtgcgca ccaccggcgg    19740

cggcgcgcgt cgcaccgtcg catgcgcggc ggtatcctgc ccctccttat tccactgatc    19800

gccgcggcga ttggcgccgt gcccggaatt gcatccgtgg ccttgcaggc gcagagacac    19860

tgattaaaaa caagttgcat gtggaaaaat caaaataaaa agtctggact ctcacgctcg    19920

cttggtcctg taactatttt gtagaatgga agacatcaac tttgcgtctc tggccccgcg    19980

acacggctcg cgcccgttca tgggaaactg gcaagatatc ggcaccagca atatgagcgg    20040

tggcgccttc agctggggct cgctgtggag cggcattaaa aatttcggtt ccaccgttaa    20100

gaactatggc agcaaggcct ggaacagcag cacaggccag atgctgaggg ataagttgaa    20160

agagcaaaat ttccaacaaa aggtggtaga tggcctggcc tctggcatta gcggggtggt    20220

ggacctggcc aaccaggcag tgcaaaataa gattaacagt aagcttgatc cccgccctcc    20280

cgtagaggag cctccaccgg ccgtggagac agtgtctcca gaggggcgtg gcgaaaagcg    20340

tccgcgcccc gacagggaag aaactctggt gacgcaaata gacgagcctc cctcgtacga    20400

ggaggcacta aagcaaggcc tgcccaccac ccgtcccatc gcgcccatgg ctaccggagt    20460

gctgggccag cacacacccg taacgctgga cctgcctccc cccgccgaca cccagcagaa    20520

acctgtgctg ccaggcccga ccgccgttgt tgtaacccgt cctagccgcg cgtccctgcg    20580

ccgcgccgcc agcggtccgc gatcgttgcg gcccgtagcc agtggcaact ggcaaagcac    20640

actgaacagc atcgtgggtc tgggggtgca atccctgaag cgccgacgat gcttctgaat    20700

agctaacgtg tcgtatgtgt gtcatgtatg cgtccatgtc gccgccagag gagctgctga    20760

gccgccgcgc gcccgctttc caagatggct accccttcga tgatgccgca gtggtcttac    20820

atgcacatct cgggccagga cgcctcggag tacctgagcc ccgggctggt gcagtttgcc    20880

cgcgccaccg agacgtactt cagcctgaat aacaagttta gaaaccccac ggtggcgcct    20940

acgcacgacg tgaccacaga ccggtcccag cgtttgacgc tgcggttcat ccctgtggac    21000

cgtgaggata ctgcgtactc gtacaaggcg cggttcaccc tagctgtggg tgataaccgt    21060

gtgctggaca tggcttccac gtactttgac atccgcggcg tgctggacag gggccctact    21120

tttaagccct actctggcac tgcctacaac gccctggctc ccaagggtgc cccaaatcct    21180

tgcgaatggg atgaagctgc tactgctctt gaaataaacc tagaagaaga ggacgatgac    21240

aacgaagacg aagtagacga gcaagctgag cagcaaaaaa ctcacgtatt tgggcaggcg    21300

ccttattctg gtataaatat tacaaaggag ggtattcaaa taggtgtcga aggtcaaaca    21360

cctaaatatg ccgataaaac atttcaacct gaacctcaaa taggagaatc tcagtggtac    21420

gaaactgaaa ttaatcatgc agctgggaga gtccttaaaa agactacccc aatgaaacca    21480

tgttacggtt catatgcaaa acccacaaat gaaaatggag ggcaaggcat tcttgtaaag    21540

caacaaaatg gaaagctaga aagtcaagtg gaaatgcaat ttttctcaac tactgaggcg    21600

accgcaggca atggtgataa cttgactcct aaagtggtat tgtacagtga agatgtagat    21660

atagaaaccc cagacactca tatttcttac atgcccacta ttaaggaagg taactcacga    21720

gaactaatgg gccaacaatc tatgcccaac aggcctaatt acattgcttt tagggacaat    21780

tttattggtc taatgtatta caacagcacg ggtaatatgg gtgttctggc gggccaagca    21840

tcgcagttga atgctgttgt agatttgcaa gacagaaaca cagagctttc ataccagctt    21900

ttgcttgatt ccattggtga tagaaccagg tacttttcta tgtggaatca ggctgttgac    21960

agctatgatc cagatgttag aattattgaa aatcatggaa ctgaagatga acttccaaat    22020

tactgctttc cactgggagg tgtgattaat acagagactc ttaccaaggt aaaacctaaa    22080

acaggtcagg aaaatggatg ggaaaaagat gctacagaat tttcagataa aaatgaaata    22140

agagttggaa ataattttgc catggaaatc aatctaaatg ccaacctgtg gagaaatttc    22200

ctgtactcca acatagcgct gtatttgccc gacaagctaa agtacagtcc ttccaacgta    22260

aaaatttctg ataacccaaa cacctacgac tacatgaaca agcgagtggt ggctcccggg    22320

ttagtggact gctacattaa ccttggagca cgctggtccc ttgactatat ggacaacgtc    22380

aacccattta accaccaccg caatgctggc ctgcgctacc gctcaatgtt gctgggcaat    22440

ggtcgctatg tgcccttcca catccaggtg cctcagaagt tctttgccat taaaaacctc    22500

cttctcctgc cgggctcata cacctacgag tggaacttca ggaaggatgt taacatggtt    22560

ctgcagagct ccctaggaaa tgacctaagg gttgacggag ccagcattaa gtttgatagc    22620

atttgccttt acgccacctt cttccccatg gcccacaaca ccgcctccac gcttgaggcc    22680

atgcttagaa acgacaccaa cgaccagtcc tttaacgact atctctccgc cgccaacatg    22740

ctctacccta tacccgccaa cgctaccaac gtgcccatat ccatcccctc ccgcaactgg    22800

gcggctttcc gcggctgggc cttcacgcgc cttaagacta aggaaacccc atcactgggc    22860

tcgggctacg acccttatta cacctactct ggctctatac cctacctaga tggaaccttt    22920

tacctcaacc acacctttaa gaaggtggcc attacctttg actcttctgt cagctggcct    22980

ggcaatgacc gcctgcttac ccccaacgag tttgaaatta agcgctcagt tgacggggag    23040

ggttacaacg ttgcccagtg taacatgacc aaagactggt tcctggtaca aatgctagct    23100

aactacaaca ttggctacca gggcttctat atcccagaga gctacaagga ccgcatgtac    23160

tccttcttta gaaacttcca gcccatgagc cgtcaggtgg tggatgatac taaatacaag    23220

gactaccaac aggtgggcat cctacaccaa cacaacaact ctggatttgt tggctacctt    23280

gcccccacca tgcgcgaagg acaggcctac cctgctaact tcccctatcc gcttataggc    23340

aagaccgcag ttgacagcat tacccagaaa aagtttcttt gcgatcgcac cctttggcgc    23400

atcccattct ccagtaactt tatgtccatg ggcgcactca cagacctggg ccaaaacctt    23460

ctctacgcca actccgccca cgcgctagac atgacttttg aggtggatcc catggacgag    23520

cccacccttc tttatgtttt gtttgaagtc tttgacgtgg tccgtgtgca ccggccgcac    23580

cgcggcgtca tcgaaaccgt gtacctgcgc acgcccttct cggccggcaa cgccacaaca    23640

taaagaagca agcaacatca acaacagctg ccgccatggg ctccagtgag caggaactga    23700

aagccattgt caaagatctt ggttgtgggc catatttttt gggcacctat gacaagcgct    23760

ttccaggctt tgtttctcca cacaagctcg cctgcgccat agtcaatacg gccggtcgcg    23820

agactggggg cgtacactgg atggcctttg cctggaaccc gcactcaaaa acatgctacc    23880

tctttgagcc ctttggcttt tctgaccagc gactcaagca ggtttaccag tttgagtacg    23940

agtcactcct gcgccgtagc gccattgctt cttcccccga ccgctgtata acgctggaaa    24000

agtccaccca aagcgtacag gggcccaact cggccgcctg tggactattc tgctgcatgt    24060

ttctccacgc ctttgccaac tggccccaaa ctcccatgga tcacaacccc accatgaacc    24120

ttattaccgg ggtacccaac tccatgctca acagtcccca ggtacagccc accctgcgtc    24180

gcaaccagga acagctctac agcttcctgg agcgccactc gccctacttc cgcagccaca    24240

gtgcgcagat taggagcgcc acttcttttt gtcacttgaa aaacatgtaa aaataatgta    24300

ctagagacac tttcaataaa ggcaaatgct tttatttgta cactctcggg tgattattta    24360

cccccaccct tgccgtctgc gccgtttaaa aatcaaaggg gttctgccgc gcatcgctat    24420

gcgccactgg cagggacacg ttgcgatact ggtgtttagt gctccactta aactcaggca    24480

caaccatccg cggcagctcg gtgaagtttt cactccacag gctgcgcacc atcaccaacg    24540

cgtttagcag gtcgggcgcc gatatcttga agtcgcagtt ggggcctccg ccctgcgcgc    24600

gcgagttgcg atacacaggg ttgcagcact ggaacactat cagcgccggg tggtgcacgc    24660

tggccagcac gctcttgtcg gagatcagat ccgcgtccag gtcctccgcg ttgctcaggg    24720

cgaacggagt caactttggt agctgccttc ccaaaaaggg cgcgtgccca ggctttgagt    24780

tgcactcgca ccgtagtggc atcaaaaggt gaccgtgccc ggtctgggcg ttaggataca    24840

gcgcctgcat aaaagccttg atctgcttaa aagccacctg agcctttgcg ccttcagaga    24900

agaacatgcc gcaagacttg ccggaaaact gattggccgg acaggccgcg tcgtgcacgc    24960

agcaccttgc gtcggtgttg gagatctgca ccacatttcg gccccaccgg ttcttcacga    25020

tcttggcctt gctagactgc tccttcagcg cgcgctgccc gttttcgctc gtcacatcca    25080

tttcaatcac gtgctcctta tttatcataa tgcttccgtg tagacactta agctcgcctt    25140

cgatctcagc gcagcggtgc agccacaacg cgcagcccgt gggctcgtga tgcttgtagg    25200

tcacctctgc aaacgactgc aggtacgcct gcaggaatcg ccccatcatc gtcacaaagg    25260

tcttgttgct ggtgaaggtc agctgcaacc cgcggtgctc ctcgttcagc caggtcttgc    25320

atacggccgc cagagcttcc acttggtcag gcagtagttt gaagttcgcc tttagatcgt    25380

tatccacgtg gtacttgtcc atcagcgcgc gcgcagcctc catgcccttc tcccacgcag    25440

acacgatcgg cacactcagc gggttcatca ccgtaatttc actttccgct tcgctgggct    25500

cttcctcttc ctcttgcgtc cgcataccac gcgccactgg gtcgtcttca ttcagccgcc    25560

gcactgtgcg cttacctcct ttgccatgct tgattagcac cggtgggttg ctgaaaccca    25620

ccatttgtag cgccacatct tctctttctt cctcgctgtc cacgattacc tctggtgatg    25680

gcgggcgctc gggcttggga gaagggcgct tctttttctt cttgggcgca atggccaaat    25740

ccgccgccga ggtcgatggc cgcgggctgg gtgtgcgcgg caccagcgcg tcttgtgatg    25800

agtcttcctc gtcctcggac tcgatacgcc gcctcatccg cttttttggg ggcgcccggg    25860

gaggcggcgg cgacggggac ggggacgaca cgtcctccat ggttggggga cgtcgcgccg    25920

caccgcgtcc gcgctcgggg gtggtttcgc gctgctcctc ttcccgactg gccatttcct    25980

tctcctatag gcagaaaaag atcatggagt cagtcgagaa gaaggacagc ctaaccgccc    26040

cctctgagtt cgccaccacc gcctccaccg atgccgccaa cgcgcctacc accttccccg    26100

tcgaggcacc cccgcttgag gaggaggaag tgattatcga gcaggaccca ggttttgtaa    26160

gcgaagacga cgaggaccgc tcagtaccaa cagaggataa aaagcaagac caggacaacg    26220

cagaggcaaa cgaggaacaa gtcgggcggg gggacgaaag gcatggcgac tacctagatg    26280

tgggagacga cgtgctgttg aagcatctgc agcgccagtg cgccattatc tgcgacgcgt    26340

tgcaagagcg cagcgatgtg cccctcgcca tagcggatgt cagccttgcc tacgaacgcc    26400

acctattctc accgcgcgta ccccccaaac gccaagaaaa cggcacatgc gagcccaacc    26460

cgcgcctcaa cttctacccc gtatttgccg tgccagaggt gcttgccacc tatcacatct    26520

ttttccaaaa ctgcaagata cccctatcct gccgtgccaa ccgcagccga gcggacaagc    26580

agctggcctt gcggcagggc gctgtcatac ctgatatcgc ctcgctcaac gaagtgccaa    26640

aaatctttga gggtcttgga cgcgacgaga agcgcgcggc aaacgctctg caacaggaaa    26700

acagcgaaaa tgaaagtcac tctggagtgt tggtggaact cgagggtgac aacgcgcgcc    26760

tagccgtact aaaacgcagc atcgaggtca cccactttgc ctacccggca cttaacctac    26820

cccccaaggt catgagcaca gtcatgagtg agctgatcgt gcgccgtgcg cagcccctgg    26880

agagggatgc aaatttgcaa gaacaaacag aggagggcct acccgcagtt ggcgacgagc    26940

agctagcgcg ctggcttcaa acgcgcgagc ctgccgactt ggaggagcga cgcaaactaa    27000

tgatggccgc agtgctcgtt accgtggagc ttgagtgcat gcagcggttc tttgctgacc    27060

cggagatgca gcgcaagcta gaggaaacat tgcactacac ctttcgacag ggctacgtac    27120

gccaggcctg caagatctcc aacgtggagc tctgcaacct ggtctcctac cttggaattt    27180

tgcacgaaaa ccgccttggg caaaacgtgc ttcattccac gctcaagggc gaggcgcgcc    27240

gcgactacgt ccgcgactgc gtttacttat ttctatgcta cacctggcag acggccatgg    27300

gcgtttggca gcagtgcttg gaggagtgca acctcaagga gctgcagaaa ctgctaaagc    27360

aaaacttgaa ggacctatgg acggccttca acgagcgctc cgtggccgcg cacctggcgg    27420

acatcatttt ccccgaacgc ctgcttaaaa ccctgcaaca gggtctgcca gacttcacca    27480

gtcaaagcat gttgcagaac tttaggaact ttatcctaga gcgctcagga atcttgcccg    27540

ccacctgctg tgcacttcct agcgactttg tgcccattaa gtaccgcgaa tgccctccgc    27600

cgctttgggg ccactgctac cttctgcagc tagccaacta ccttgcctac cactctgaca    27660

taatggaaga cgtgagcggt gacggtctac tggagtgtca ctgtcgctgc aacctatgca    27720

ccccgcaccg ctccctggtt tgcaattcgc agctgcttaa cgaaagtcaa attatcggta    27780

cctttgagct gcagggtccc tcgcctgacg aaaagtccgc ggctccgggg ttgaaactca    27840

ctccggggct gtggacgtcg gcttaccttc gcaaatttgt acctgaggac taccacgccc    27900

acgagattag gttctacgaa gaccaatccc gcccgccaaa tgcggagctt accgcctgcg    27960

tcattaccca gggccacatt cttggccaat tgcaagccat caacaaagcc cgccaagagt    28020

ttctgctacg aaagggacgg ggggtttact tggaccccca gtccggcgag gagctcaacc    28080

caatcccccc gccgccgcag ccctatcagc agcagccgcg ggcccttgct tcccaggatg    28140

gcacccaaaa agaagctgca gctgccgccg ccacccacgg acgaggagga atactgggac    28200

agtcaggcag aggaggtttt ggacgaggag gaggaggaca tgatggaaga ctgggagagc    28260

ctagacgagg aagcttccga ggtcgaagag gtgtcagacg aaacaccgtc accctcggtc    28320

gcattcccct cgccggcgcc ccagaaatcg gcaaccggtt ccagcatggc tacaacctcc    28380

gctcctcagg cgccgccggc actgcccgtt cgccgaccca accgtagatg ggacaccact    28440

ggaaccaggg ccggtaagtc caagcagccg ccgccgttag cccaagagca acaacagcgc    28500

caaggctacc gctcatggcg cgggcacaag aacgccatag ttgcttgctt gcaagactgt    28560

gggggcaaca tctccttcgc ccgccgcttt cttctctacc atcacggcgt ggccttcccc    28620

cgtaacatcc tgcattacta ccgtcatctc tacagcccat actgcaccgg cggcagcggc    28680

agcggcagca acagcagcgg ccacacagaa gcaaaggcga ccggatagca agactctgac    28740

aaagcccaag aaatccacag cggcggcagc agcaggagga ggagcgctgc gtctggcgcc    28800

caacgaaccc gtatcgaccc gcgagcttag aaacaggatt tttcccactc tgtatgctat    28860

atttcaacag agcaggggcc aagaacaaga gctgaaaata aaaaacaggt ctctgcgatc    28920

cctcacccgc agctgcctgt atcacaaaag cgaagatcag cttcggcgca cgctggaaga    28980

cgcggaggct ctcttcagta aatactgcgc gctgactctt aaggactagt ttcgcgccct    29040

ttctcaaatt taagcgcgaa aactacgtca tctccagcgg ccacacccgg cgccagcacc    29100

tgtcgtcagc gccattatga gcaaggaaat tcccacgccc tacatgtgga gttaccagcc    29160

acaaatggga cttgcggctg gagctgccca agactactca acccgaataa actacatgag    29220

cgcgggaccc cacatgatat cccgggtcaa cggaatccgc gcccaccgaa accgaattct    29280

cttggaacag gcggctatta ccaccacacc tcgtaataac cttaatcccc gtagttggcc    29340

cgctgccctg gtgtaccagg aaagtcccgc tcccaccact gtggtacttc ccagagacgc    29400

ccaggccgaa gttcagatga ctaactcagg ggcgcagctt gcgggcggct ttcgtcacag    29460

ggtgcggtcg cccgggcagg gtataactca cctgacaatc agagggcgag gtattcagct    29520

caacgacgag tcggtgagct cctcgcttgg tctccgtccg gacgggacat ttcagatcgg    29580

cggcgccggc cgtccttcat tcacgcctcg tcaggcaatc ctaactctgc agacctcgtc    29640

ctctgagccg cgctctggag gcattggaac tctgcaattt attgaggagt ttgtgccatc    29700

ggtctacttt aaccccttct cgggacctcc cggccactat ccggatcaat ttattcctaa    29760

ctttgacgcg gtaaaggact cggcggacgg ctacgactga atgttaagtg gagaggcaga    29820

gcaactgcgc ctgaaacacc tggtccactg tcgccgccac aagtgctttg cccgcgactc    29880

cggtgagttt tgctactttg aattgcccga ggatcatatc gagggcccgg cgcacggcgt    29940

ccggcttacc gcccagggag agcttgcccg tagcctgatt cgggagttta cccagcgccc    30000

cctgctagtt gagcgggaca ggggaccctg tgttctcact gtgatttgca actgtcctaa    30060

ccttggatta catcaagatc tttgttgcca tctctgtgct gagtataata aatacagaaa    30120

ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc caccgtcttc acccgcccaa    30180

gcaaaccaag gcgaacctta cctggtactt ttaacatctc tccctctgtg atttacaaca    30240

gtttcaaccc agacggagtg agtctacgag agaacctctc cgagctcagc tactccatca    30300

gaaaaaacac caccctcctt acctgccggg aacgtacgag tgcgtcaccg gccgctgcac    30360

cacacctacc gcctgaccgt aaaccagact ttttccggac agacctcaat aactctgttt    30420

accagaacag gaggtgagct tagaaaaccc ttagggtatt aggccaaagg cgcagctact    30480

gtggggttta tgaacaattc aagcaactct acgggctatt ctaattcagg tttctctagg    30540

gttggggtta ttctctgtct tgtgattctc tttattctta tactaacgct tctctgccta    30600

aggctcgccg cctgctgtgt gcacatttgc atttattgtc agctttttaa acgctggggt    30660

cgccacccaa gatgattagg tacataatcc taggtttact cacccttgcg tcagcccacg    30720

gtaccaccca aaaggtggat tttaaggagc cagcctgtaa tgttacattc gcagctgaag    30780

ctaatgagtg caccactctt ataaaatgca ccacagaaca tgaaaagctg cttattcgcc    30840

acaaaaacaa aattggcaag tatgctgttt atgctatttg gcagccaggt gacactacag    30900

agtataatgt tacagttttc cagggtaaaa gtcataaaac ttttatgtat acttttccat    30960

tttatgaaat gtgcgacatt accatgtaca tgagcaaaca gtataagttg tggcccccac    31020

aaaattgtgt ggaaaacact ggcactttct gctgcactgc tatgctaatt acagtgctcg    31080

ctttggtctg taccctactc tatattaaat acaaaagcag acgcagcttt attgaggaaa    31140

agaaaatgcc ttaatttact aagttacaaa gctaatgtca ccactaactg ctttactcgc    31200

tgcttgcaaa acaaattcaa aaagttagca ttataattag aataggattt aaaccccccg    31260

gtcatttcct gctcaatacc attcccctga acaattgact ctatgtggga tatgctccag    31320

cgctacaacc ttgaagtcag gcttcctgga tgtcagcatc tgactttggc cagcacctgt    31380

cccgcggatt tgttccagtc caactacagc gacccaccct aacagagatg accaacacaa    31440

ccaacgcggc cgccgctacc ggacttacat ctaccacaaa tacaccccaa gtttctgcct    31500

ttgtcaataa ctgggataac ttgggcatgt ggtggttctc catagcgctt atgtttgtat    31560

gccttattat tatgtggctc atctgctgcc taaagcgcaa acgcgcccga ccacccatct    31620

atagtcccat cattgtgcta cacccaaaca atgatggaat ccatagattg gacggactga    31680

aacacatgtt cttttctctt acagtatgat aataaaaaaa aataataaag catcacttac    31740

ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt gccctcctcc    31800

cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct aaatggaatg    31860

tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt gcagatgaag    31920

cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac ggaaaccggt    31980

cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt tcaagagagt    32040

ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa tggcatgctt    32100

gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac ctcccaaaat    32160

gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct ggaaatatct    32220

gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc tctaatggtc    32280

gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga ctccaaactt    32340

agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct gcaaacatca    32400

ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc ccctctaact    32460

actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca aaatggaaaa    32520

ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac tttgaccgta    32580

gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt tactggagcc    32640

ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact aaggattgat    32700

tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca aaaccaacta    32760

aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt ggatattaac    32820

tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct tgaggttaac    32880

ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa tgcaggagat    32940

gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac aaaaattggc    33000

catggcctag aatttgattc aaacaaggct atggttccta aactaggaac tggccttagt    33060

tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct aactttgtgg    33120

accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc taaactcact    33180

ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt ggctgttaaa    33240

ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat aagatttgac    33300

gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa ctttagaaat    33360

ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc taacctatca    33420

gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca agtttactta    33480

aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac acaggaaaca    33540

ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc tggccacaac    33600

tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc ccaagaataa    33660

agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa tttcaagtca    33720

tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac cgtaccttaa    33780

tcaaactcac agaaccctag tattcaacct gccacctccc tcccaacaca cagagtacac    33840

agtcctttct ccccggctgg ccttaaaaag catcatatca tgggtaacag acatattctt    33900

aggtgttata ttccacacgg tttcctgtcg agccaaacgc tcatcagtga tattaataaa    33960

ctccccgggc agctcactta agttcatgtc gctgtccagc tgctgagcca caggctgctg    34020

tccaacttgc ggttgcttaa cgggcggcga aggagaagtc cacgcctaca tgggggtaga    34080

gtcataatcg tgcatcagga tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg    34140

ccgccgccgc tccgtcctgc aggaatacaa catggcagtg gtctcctcag cgatgattcg    34200

caccgcccgc agcataaggc gccttgtcct ccgggcacag cagcgcaccc tgatctcact    34260

taaatcagca cagtaactgc agcacagcac cacaatattg ttcaaaatcc cacagtgcaa    34320

ggcgctgtat ccaaagctca tggcggggac cacagaaccc acgtggccat cataccacaa    34380

gcgcaggtag attaagtggc gacccctcat aaacacgctg gacataaaca ttacctcttt    34440

tggcatgttg taattcacca cctcccggta ccatataaac ctctgattaa acatggcgcc    34500

atccaccacc atcctaaacc agctggccaa aacctgcccg ccggctatac actgcaggga    34560

accgggactg gaacaatgac agtggagagc ccaggactcg taaccatgga tcatcatgct    34620

cgtcatgata tcaatgttgg cacaacacag gcacacgtgc atacacttcc tcaggattac    34680

aagctcctcc cgcgttagaa ccatatccca gggaacaacc cattcctgaa tcagcgtaaa    34740

tcccacactg cagggaagac ctcgcacgta actcacgttg tgcattgtca aagtgttaca    34800

ttcgggcagc agcggatgat cctccagtat ggtagcgcgg gtttctgtct caaaaggagg    34860

tagacgatcc ctactgtacg gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt    34920

catgccaaat ggaacgccgg acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt    34980

gacaaacaga tctgcgtctc cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt    35040

atatccactc tctcaaagca tccaggcgcc ccctggcttc gggttctatg taaactcctt    35100

catgcgccgc tgccctgata acatccacca ccgcagaata agccacaccc agccaaccta    35160

cacattcgtt ctgcgagtca cacacgggag gagcgggaag agctggaaga accatgtttt    35220

tttttttatt ccaaaagatt atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc    35280

tcccctccgg tggcgtggtc aaactctaca gccaaagaac agataatggc atttgtaaga    35340

tgttgcacaa tggcttccaa aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta    35400

aacccttcag ggtgaatctc ctctataaac attccagcac cttcaaccat gcccaaataa    35460

ttctcatctc gccaccttct caatatatct ctaagcaaat cccgaatatt aagtccggcc    35520

attgtaaaaa tctgctccag agcgccctcc accttcagcc tcaagcagcg aatcatgatt    35580

gcaaaaattc aggttcctca cagacctgta taagattcaa aagcggaaca ttaacaaaaa    35640

taccgcgatc ccgtaggtcc cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac    35700

ggaccagcgc ggccacttcc ccgccaggaa ccttgacaaa agaacccaca ctgattatga    35760

cacgcatact cggagctatg ctaaccagcg tagccccgat gtaagctttg ttgcatgggc    35820

ggcgatataa aatgcaaggt gctgctcaaa aaatcaggca aagcctcgcg caaaaaagaa    35880

agcacatcgt agtcatgctc atgcagataa aggcaggtaa gctccggaac caccacagaa    35940

aaagacacca tttttctctc aaacatgtct gcgggtttct gcataaacac aaaataaaat    36000

aacaaaaaaa catttaaaca ttagaagcct gtcttacaac aggaaaaaca acccttataa    36060

gcataagacg gactacggcc atgccggcgt gaccgtaaaa aaactggtca ccgtgattaa    36120

aaagcaccac cgacagctcc tcggtcatgt ccggagtcat aatgtaagac tcggtaaaca    36180

catcaggttg attcatcggt cagtgctaaa aagcgaccga aatagcccgg gggaatacat    36240

acccgcaggc gtagagacaa cattacagcc cccataggag gtataacaaa attaatagga    36300

gagaaaaaca cataaacacc tgaaaaaccc tcctgcctag gcaaaatagc accctcccgc    36360

tccagaacaa catacagcgc ttcacagcgg cagcctaaca gtcagcctta ccagtaaaaa    36420

agaaaaccta ttaaaaaaac accactcgac acggcaccag ctcaatcagt cacagtgtaa    36480

aaaagggcca agtgcagagc gagtatatat aggactaaaa aatgacgtaa cggttaaagt    36540

ccacaaaaaa cacccagaaa accgcacgcg aacctacgcc cagaaacgaa agccaaaaaa    36600

cccacaactt cctcaaatcg tcacttccgt tttcccacgt tacgtaactt cccattttaa    36660

gaaaactaca attcccaaca catacaagtt actccgccct aaaacctacg tcacccgccc    36720

cgttcccacg ccccgcgcca cgtcacaaac tccaccccct cattatcata ttggcttcaa    36780

tccaaaataa ggtatattat tgatgatg                                       36808


<210>  15
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified E1b-19k reigon

<400>  15
atcttggtta catctgacct cgtcgagtca ccaggcgctt ttccaa                      46


<210>  16
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified E3 region

<400>  16
tcttttctct tacagtatga taataaaaaa aaataataaa gcatcactta c                51


<210>  17
<211>  953
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine CD80 cloned into E1b-19k region with flanking adenoviral 
       sequences

<400>  17
atctgacctc gtcgacatgg cttgcaattg tcagttgatg caggatacac cactcctcaa       60

gtttccatgt ccaaggctca ttcttctctt tgtgctgctg attcgtcttt cacaagtgtc      120

ttcagatgtt gatgaacaac tgtccaagtc agtgaaagat aaggtattgc tgccttgccg      180

ttacaactct cctcatgaag atgagtctga agaccgaatc tactggcaaa aacatgacaa      240

agtggtgctg tctgtcattg ctgggaaact aaaagtgtgg cccgagtata agaaccggac      300

tttatatgac aacactacct actctcttat catcctgggc ctggtccttt cagaccgggg      360

cacatacagc tgtgtcgttc aaaagaagga aagaggaacg tatgaagtta aacacttggc      420

tttagtaaag ttgtccatca aagctgactt ctctaccccc aacataactg agtctggaaa      480

cccatctgca gacactaaaa ggattacctg ctttgcttcc gggggtttcc caaagcctcg      540

cttctcttgg ttggaaaatg gaagagaatt acctggcatc aatacgacaa tttcccagga      600

tcctgaatct gaattgtaca ccattagtag ccaactagat ttcaatacga ctcgcaacca      660

caccattaag tgtctcatta aatatggaga tgctcacgtg tcagaggact tcacctggga      720

aaaaccccca gaagaccctc ctgatagcaa gaacacactt gtgctctttg gggcaggatt      780

cggcgcagta ataacagtcg tcgtcatcgt tgtcatcatc aaatgcttct gtaagcacag      840

aagctgtttc agaagaaatg aggcaagcag agaaacaaac aacagcctta ccttcgggcc      900

tgaagaagca ttagctgaac agaccgtctt cctttagctc gagtcaccag gcg             953


<210>  18
<211>  947
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD80 cloned into E1b-19k region with flanking adenoviral 
       sequences

<400>  18
gcgccgtggg ctaatcttgg ttacatctga cctcgtcgac atgggccaca cacggaggca       60

gggaacatca ccatccaagt gtccatacct caatttcttt cagctcttgg tgctggctgg      120

tctttctcac ttctgttcag gtgttatcca cgtgaccaag gaagtgaaag aagtggcaac      180

gctgtcctgt ggtcacaatg tttctgttga agagctggca caaactcgca tctactggca      240

aaaggagaag aaaatggtgc tgactatgat gtctggggac atgaatatat ggcccgagta      300

caagaaccgg accatctttg atatcactaa taacctctcc attgtgatcc tggctctgcg      360

cccatctgac gagggcacat acgagtgtgt tgttctgaag tatgaaaaag acgctttcaa      420

gcgggaacac ctggctgaag tgacgttatc agtcaaagct gacttcccta cacctagtat      480

atctgacttt gaaattccaa cttctaatat tagaaggata atttgctcaa cctctggagg      540

ttttccagag cctcacctct cctggttgga aaatggagaa gaattaaatg ccatcaacac      600

aacagtttcc caagatcctg aaactgagct ctatgctgtt agcagcaaac tggatttcaa      660

tatgacaacc aaccacagct tcatgtgtct catcaagtat ggacatttaa gagtgaatca      720

gaccttcaac tggaatacaa ccaagcaaga gcattttcct gataacctgc tcccatcctg      780

ggccattacc ttaatctcag taaatggaat ttttgtgata tgctgcctga cctactgctt      840

tgccccaaga tgcagagaga gaaggaggaa tgagagattg agaagggaaa gtgtacgccc      900

tgtataactc gagtcaccag gcgcttttcc aagagaaggt catcaag                    947


<210>  19
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine CD137L cloned into modified E3 region with flanking 
       adenoviral sequences

<400>  19
atgttctttt ctcttacagt atgattaaat gagacatgga ccagcacaca cttgatgtgg       60

aggataccgc ggatgccaga catccagcag gtacttcgtg cccctcggat gcggcgctcc      120

tcagagatac cgggctcctc gcggacgctg cgctcctctc agatactgtg cgccccacaa      180

atgccgcgct ccccacggat gctgcctacc ctgcggttaa tgttcgggat cgcgaggccg      240

cgtggccgcc tgcactgaac ttctgttccc gccacccaaa gctctatggc ctagtcgctt      300

tggttttgct gcttctgatc gccgcctgtg ttcctatctt cacccgcacc gagcctcggc      360

cagcgctcac aatcaccacc tcgcccaacc tgggtacccg agagaataat gcagaccagg      420

tcacccctgt ttcccacatt ggctgcccca acactacaca acagggctct cctgtgttcg      480

ccaagctact ggctaaaaac caagcatcgt tgtgcaatac aactctgaac tggcacagcc      540

aagatggagc tgggagctca tacctatctc aaggtctgag gtacgaagaa gacaaaaagg      600

agttggtggt agacagtccc gggctctact acgtattttt ggaactgaag ctcagtccaa      660

cattcacaaa cacaggccac aaggtgcagg gctgggtctc tcttgttttg caagcaaagc      720

ctcaggtaga tgactttgac aacttggccc tgacagtgga actgttccct tgctccatgg      780

agaacaagtt agtggaccgt tcctggagtc aactgttgct cctgaaggct ggccaccgcc      840

tcagtgtggg tctgagggct tatctgcatg gagcccagga tgcatacaga gactgggagc      900

tgtcttatcc caacaccacc agctttggac tctttcttgt gaaacccgac aacccatggg      960

aatgaggtct caaagatctt attcccttta actaataaa                             999


<210>  20
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD137L cloned into modified E3 region with flanking 
       adenoviral sequences

<400>  20
atgttctttt ctcttacagt atgattaaat gagacatgga atacgcctct gacgcttcac       60

tggaccccga agccccgtgg cctcctgcac ctcgcgctcg cgcctgccgc gtactgcctt      120

gggccctggt cgcggggctg ctgctcctgc tcctgctcgc tgctgcatgc gctgtatttc      180

ttgcatgccc atgggctgtg tctggggctc gcgcatcacc tggctccgcg gccagcccga      240

gactccgcga gggtcccgag ctttcgcccg acgatcccgc cggcctcttg gacctgcggc      300

agggcatgtt tgcgcagctg gtggcccaaa atgttctgct gatcgatggg cccctgagct      360

ggtacagtga cccaggcctg gcaggcgtgt ccctgacggg gggcctgagc tacaaagagg      420

acacgaagga gctggtggtg gccaaggctg gagtctacta tgtcttcttt caactagagc      480

tgcggcgcgt ggtggccggc gagggctcag gctccgtttc acttgcgctg cacctgcagc      540

cactgcgctc tgctgctggg gccgccgccc tggctttgac cgtggacctg ccacccgcct      600

cctccgaggc tcggaactcg gccttcggtt tccagggccg cttgctgcac ctgagtgccg      660

gccagcgcct gggcgtccat cttcacactg aggccagggc acgccatgcc tggcagctta      720

cccagggcgc cacagtcttg ggactcttcc gggtgacccc cgaaatccca gccggactcc      780

cttcaccgag gtcggaataa ggtctcaaag atcttattcc ctttaactaa taaa            834


<210>  21
<211>  2212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD80 - IRES - CD137L cloned into modified E1b-19k region 
       with flanking adenoviral sequences

<400>  21
ctgacctcgt cgacatgggc cacacacgga ggcagggaac atcaccatcc aagtgtccat       60

acctcaattt ctttcagctc ttggtgctgg ctggtctttc tcacttctgt tcaggtgtta      120

tccacgtgac caaggaagtg aaagaagtgg caacgctgtc ctgtggtcac aatgtttctg      180

ttgaagagct ggcacaaact cgcatctact ggcaaaagga gaagaaaatg gtgctgacta      240

tgatgtctgg ggacatgaat atatggcccg agtacaagaa ccggaccatc tttgatatca      300

ctaataacct ctccattgtg atcctggctc tgcgcccatc tgacgagggc acatacgagt      360

gtgttgttct gaagtatgaa aaagacgctt tcaagcggga acacctggct gaagtgacgt      420

tatcagtcaa agctgacttc cctacaccta gtatatctga ctttgaaatt ccaacttcta      480

atattagaag gataatttgc tcaacctctg gaggttttcc agagcctcac ctctcctggt      540

tggaaaatgg agaagaatta aatgccatca acacaacagt ttcccaagat cctgaaactg      600

agctctatgc tgttagcagc aaactggatt tcaatatgac aaccaaccac agcttcatgt      660

gtctcatcaa gtatggacat ttaagagtga atcagacctt caactggaat acaaccaagc      720

aagagcattt tcctgataac ctgctcccat cctgggccat taccttaatc tcagtaaatg      780

gaatttttgt gatatgctgc ctgacctact gctttgcccc aagatgcaga gagagaagga      840

ggaatgagag attgagaagg gaaagtgtac gccctgtata ataacgttac tggccgaagc      900

cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct      960

tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt     1020

ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct     1080

ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc     1140

ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag     1200

gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc     1260

tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga     1320

tctgatctgg ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc     1380

taggcccccc gaaccacggg gacgtggttt tcctttgaaa aacacgatga taatatggaa     1440

tacgcctctg acgcttcact ggaccccgaa gccccgtggc ctcctgcacc tcgcgctcgc     1500

gcctgccgcg tactgccttg ggccctggtc gcggggctgc tgctcctgct cctgctcgct     1560

gctgcatgcg ctgtatttct tgcatgccca tgggctgtgt ctggggctcg cgcatcacct     1620

ggctccgcgg ccagcccgag actccgcgag ggtcccgagc tttcgcccga cgatcccgcc     1680

ggcctcttgg acctgcggca gggcatgttt gcgcagctgg tggcccaaaa tgttctgctg     1740

atcgatgggc ccctgagctg gtacagtgac ccaggcctgg caggcgtgtc cctgacgggg     1800

ggcctgagct acaaagagga cacgaaggag ctggtggtgg ccaaggctgg agtctactat     1860

gtcttctttc aactagagct gcggcgcgtg gtggccggcg agggctcagg ctccgtttca     1920

cttgcgctgc acctgcagcc actgcgctct gctgctgggg ccgccgccct ggctttgacc     1980

gtggacctgc cacccgcctc ctccgaggct cggaactcgg ccttcggttt ccagggccgc     2040

ttgctgcacc tgagtgccgg ccagcgcctg ggcgtccatc ttcacactga ggccagggca     2100

cgccatgcct ggcagcttac ccagggcgcc acagtcttgg gactcttccg ggtgaccccc     2160

gaaatcccag ccggactccc ttcaccgagg tcggaataac tcgagtcacc ag             2212


<210>  22
<211>  36845
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Adenovirus with human CD80 - IRES - CD137L - IRES - ICAM1 cloned 
       into modified        E1b-19k region

<400>  22
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgttttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg      240

aataagagga agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta      300

gggccgcggg gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt      360

ttccgcgttc cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat      420

ttatacccgg tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc      480

tccgagccgc tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta      540

ttaccgaaga aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata      600

atcttccacc tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg      660

tgacggcccc cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa      720

tgttggcggt gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg      780

agccgcctca cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt      840

ctatgccaaa ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac      900

ccagtgacga cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg      960

ggcacggttg caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt     1020

gttcgctttg ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg     1080

cagtgggtga tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt     1140

gtggtttaaa gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc     1200

tgagcccgag ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc     1260

tatcctgaga cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg     1320

tgactccggt ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat     1380

taaaccagtt gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt     1440

gcttaacgag cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt     1500

aaacctgtga ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt     1560

aataaagggt gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg     1620

gtatataatg cgccgtgggc taatcttggt tacatctgac ctcgtcgaca tgggccacac     1680

acggaggcag ggaacatcac catccaagtg tccatacctc aatttctttc agctcttggt     1740

gctggctggt ctttctcact tctgttcagg tgttatccac gtgaccaagg aagtgaaaga     1800

agtggcaacg ctgtcctgtg gtcacaatgt ttctgttgaa gagctggcac aaactcgcat     1860

ctactggcaa aaggagaaga aaatggtgct gactatgatg tctggggaca tgaatatatg     1920

gcccgagtac aagaaccgga ccatctttga tatcactaat aacctctcca ttgtgatcct     1980

ggctctgcgc ccatctgacg agggcacata cgagtgtgtt gttctgaagt atgaaaaaga     2040

cgctttcaag cgggaacacc tggctgaagt gacgttatca gtcaaagctg acttccctac     2100

acctagtata tctgactttg aaattccaac ttctaatatt agaaggataa tttgctcaac     2160

ctctggaggt tttccagagc ctcacctctc ctggttggaa aatggagaag aattaaatgc     2220

catcaacaca acagtttccc aagatcctga aactgagctc tatgctgtta gcagcaaact     2280

ggatttcaat atgacaacca accacagctt catgtgtctc atcaagtatg gacatttaag     2340

agtgaatcag accttcaact ggaatacaac caagcaagag cattttcctg ataacctgct     2400

cccatcctgg gccattacct taatctcagt aaatggaatt tttgtgatat gctgcctgac     2460

ctactgcttt gccccaagat gcagagagag aaggaggaat gagagattga gaagggaaag     2520

tgtacgccct gtataacgtt actggccgaa gccgcttgga ataaggccgg tgtgcgtttg     2580

tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc cggaaacctg     2640

gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa ggaatgcaag     2700

gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga caaacaacgt     2760

ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc     2820

aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc cacgttgtga     2880

gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac aaggggctga     2940

aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg tgcacatgct     3000

ttacatgtgt ttagtcgagg ttaaaaaacg tctaggcccc ccgaaccacg gggacgtggt     3060

tttcctttga aaaacacgat gataatatgg aatacgcctc tgacgcttca ctggaccccg     3120

aagccccgtg gcctcccgcg ccccgcgctc gcgcctgccg cgtactgcct tgggccctgg     3180

tcgcggggct gctgctgctg ctgctgctcg ctgccgcctg cgccgtcttc ctcgcctgcc     3240

cctgggccgt gtccggggct cgcgcctcgc ccggctccgc ggccagcccg agactccgcg     3300

agggtcccga gctttcgccc gacgatcccg ccggcctctt ggacctgcgg cagggcatgt     3360

ttgcgcagct ggtggcccaa aatgttctgc tgatcgatgg gcccctgagc tggtacagtg     3420

acccaggcct ggcaggcgtg tccctgacgg ggggcctgag ctacaaagag gacacgaagg     3480

agctggtggt ggccaaggct ggagtctact atgtcttctt tcaactagag ctgcggcgcg     3540

tggtggccgg cgagggctca ggctccgttt cacttgcgct gcacctgcag ccactgcgct     3600

ctgctgctgg ggccgccgcc ctggctttga ccgtggacct gccacccgcc tcctccgagg     3660

ctcggaactc ggccttcggt ttccagggcc gcttgctgca cctgagtgcc ggccagcgcc     3720

tgggcgtcca tcttcacact gaggccaggg cacgccatgc ctggcagctt acccagggcg     3780

ccacagtctt gggactcttc cgggtgaccc ccgaaatccc agccggactc ccttcaccga     3840

ggtcggaagg tttccacaac tgataaaact cgtgcaactt gaaactccgc ctggtctttc     3900

caggtctaga ggggttacac tttgtactgt gctcgactcc acgcccggtc cactggcggg     3960

tgttagtagc agcactgttg tttcgtagcg gagcatggtg gccgtgggaa ctcctccttg     4020

gtgacaaggg cccacggggc cgaaagccac gtccagacgg acccaccatg tgtgcaaccc     4080

cagcacggca acttttactg cgaacaccac cttaaggtga cactggtact ggtactcggt     4140

cactggtgac aggctaagga tgcccttcag gtaccccgag gtaacacggg acactcggga     4200

tctgagaagg ggattgggac ttctttaaaa gtgcccagtt taaaaagctt ctacgcctga     4260

ataggcgacc ggaggccggc gcctttccat tacccactac taaatccatg gctcccagca     4320

gcccccggcc cgcgctgccc gcactcctgg tcctgctcgg ggctctgttc ccaggacctg     4380

gcaatgccca gacatctgtg tccccctcaa aagtcatcct gccccgggga ggctccgtgc     4440

tggtgacatg cagcacctcc tgtgaccagc ccaagttgtt gggcatagag accccgttgc     4500

ctaaaaagga gttgctcctg cctgggaaca accggaaggt gtatgaactg agcaatgtgc     4560

aagaagatag ccaaccaatg tgctattcaa actgccctga tgggcagtca acagctaaaa     4620

ccttcctcac cgtgtactgg actccagaac gggtggaact ggcacccctc ccctcttggc     4680

agccagtggg caagaacctt accctacgct gccaggtgga gggtggggca ccccgggcca     4740

acctcaccgt ggtgctgctc cgtggggaga aggagctgaa acgggagcca gctgtggggg     4800

agcccgctga ggtcacgacc acggtgctgg tgaggagaga tcaccatgga gccaatttct     4860

cgtgccgcac tgaactggac ctgcggcccc aagggctgga gctgtttgag aacacctcgg     4920

ccccctacca gctccagacc tttgtcctgc cagcgactcc cccacaactt gtcagccccc     4980

gggtcctaga ggtggacacg caggggaccg tggtctgttc cctggacggg ctgttcccag     5040

tctcggaggc ccaggtccac ctggcactgg gggaccagag gttgaacccc acagtcacct     5100

atggcaacga ctccttctcg gccaaggcct cagtcagtgt gaccgcagag gacgagggca     5160

cccagcggct gacgtgtgca gtaatactgg ggaaccagag ccaggagaca ctgcagacag     5220

tgaccatcta cagctttccg gcgcccaacg tgattctgac gaagccagag gtctcagaag     5280

ggaccgaggt gacagtgaag tgtgaggccc accctagagc caaggtgacg ctgaatgggg     5340

ttccagccca gccactgggc ccgagggccc agctcctgct gaaggccacc ccagaggaca     5400

acgggcgcag cttctcctgc tctgcaaccc tggaggtggc cggccagctt atacacaaga     5460

accagacccg ggagcttcgt gtcctgtatg gcccccgact ggacgagagg gattgtccgg     5520

gaaactggac gtggccagaa aattcccagc agactccaat gtgccaggct tgggggaacc     5580

cattgcccga gctcaagtgt ctaaaggatg gcactttccc actgcccatc ggggaatcag     5640

tgactgtcac tcgagatctt gagggcacct acctctgtcg ggccaggagc actcaagggg     5700

aggtcacccg caaggtgacc gtgaatgtgc tctccccccg gtatgagatt gtcatcatca     5760

ctgtggtagc agccgcagtc ataatgggca ctgcaggcct cagcacgtac ctctataacc     5820

gccagcggaa gatcaagaaa tacagactac aacaggccca aaaagggacc cccatgaaac     5880

cgaacacaca agccacgcct ccctgactcg agtcaccagg cgcttttcca agagaaggtc     5940

atcaagactt tggatttttc cacaccgggg cgcgctgcgg ctgctgttgc ttttttgagt     6000

tttataaagg ataaatggag cgaagaaacc catctgagcg gggggtacct gctggatttt     6060

ctggccatgc atctgtggag agcggttgtg agacacaaga atcgcctgct actgttgtct     6120

tccgtccgcc cggcgataat accgacggag gagcagcagc agcagcagga ggaagccagg     6180

cggcggcggc aggagcagag cccatggaac ccgagagccg gcctggaccc tcgggaatga     6240

atgttgtaca ggtggctgaa ctgtatccag aactgagacg cattttgaca attacagagg     6300

atgggcaggg gctaaagggg gtaaagaggg agcggggggc ttgtgaggct acagaggagg     6360

ctaggaatct agcttttagc ttaatgacca gacaccgtcc tgagtgtatt acttttcaac     6420

agatcaagga taattgcgct aatgagcttg atctgctggc gcagaagtat tccatagagc     6480

agctgaccac ttactggctg cagccagggg atgattttga ggaggctatt agggtatatg     6540

caaaggtggc acttaggcca gattgcaagt acaagatcag caaacttgta aatatcagga     6600

attgttgcta catttctggg aacggggccg aggtggagat agatacggag gatagggtgg     6660

cctttagatg tagcatgata aatatgtggc cgggggtgct tggcatggac ggggtggtta     6720

ttatgaatgt aaggtttact ggccccaatt ttagcggtac ggttttcctg gccaatacca     6780

accttatcct acacggtgta agcttctatg ggtttaacaa tacctgtgtg gaagcctgga     6840

ccgatgtaag ggttcggggc tgtgcctttt actgctgctg gaagggggtg gtgtgtcgcc     6900

ccaaaagcag ggcttcaatt aagaaatgcc tctttgaaag gtgtaccttg ggtatcctgt     6960

ctgagggtaa ctccagggtg cgccacaatg tggcctccga ctgtggttgc ttcatgctag     7020

tgaaaagcgt ggctgtgatt aagcataaca tggtatgtgg caactgcgag gacagggcct     7080

ctcagatgct gacctgctcg gacggcaact gtcacctgct gaagaccatt cacgtagcca     7140

gccactctcg caaggcctgg ccagtgtttg agcataacat actgacccgc tgttccttgc     7200

atttgggtaa caggaggggg gtgttcctac cttaccaatg caatttgagt cacactaaga     7260

tattgcttga gcccgagagc atgtccaagg tgaacctgaa cggggtgttt gacatgacca     7320

tgaagatctg gaaggtgctg aggtacgatg agacccgcac caggtgcaga ccctgcgagt     7380

gtggcggtaa acatattagg aaccagcctg tgatgctgga tgtgaccgag gagctgaggc     7440

ccgatcactt ggtgctggcc tgcacccgcg ctgagtttgg ctctagcgat gaagatacag     7500

attgaggtac tgaaatgtgt gggcgtggct taagggtggg aaagaatata taaggtgggg     7560

gtcttatgta gttttgtatc tgttttgcag cagccgccgc cgccatgagc accaactcgt     7620

ttgatggaag cattgtgagc tcatatttga caacgcgcat gcccccatgg gccggggtgc     7680

gtcagaatgt gatgggctcc agcattgatg gtcgccccgt cctgcccgca aactctacta     7740

ccttgaccta cgagaccgtg tctggaacgc cgttggagac tgcagcctcc gccgccgctt     7800

cagccgctgc agccaccgcc cgcgggattg tgactgactt tgctttcctg agcccgcttg     7860

caagcagtgc agcttcccgt tcatccgccc gcgatgacaa gttgacggct cttttggcac     7920

aattggattc tttgacccgg gaacttaatg tcgtttctca gcagctgttg gatctgcgcc     7980

agcaggtttc tgccctgaag gcttcctccc ctcccaatgc ggtttaaaac ataaataaaa     8040

aaccagactc tgtttggatt tggatcaagc aagtgtcttg ctgtctttat ttaggggttt     8100

tgcgcgcgcg gtaggcccgg gaccagcggt ctcggtcgtt gagggtcctg tgtatttttt     8160

ccaggacgtg gtaaaggtga ctctggatgt tcagatacat gggcataagc ccgtctctgg     8220

ggtggaggta gcaccactgc agagcttcat gctgcggggt ggtgttgtag atgatccagt     8280

cgtagcagga gcgctgggcg tggtgcctaa aaatgtcttt cagtagcaag ctgattgcca     8340

ggggcaggcc cttggtgtaa gtgtttacaa agcggttaag ctgggatggg tgcatacgtg     8400

gggatatgag atgcatcttg gactgtattt ttaggttggc tatgttccca gccatatccc     8460

tccggggatt catgttgtgc agaaccacca gcacagtgta tccggtgcac ttgggaaatt     8520

tgtcatgtag cttagaagga aatgcgtgga agaacttgga gacgcccttg tgacctccaa     8580

gattttccat gcattcgtcc ataatgatgg caatgggccc acgggcggcg gcctgggcga     8640

agatatttct gggatcacta acgtcatagt tgtgttccag gatgagatcg tcataggcca     8700

tttttacaaa gcgcgggcgg agggtgccag actgcggtat aatggttcca tccggcccag     8760

gggcgtagtt accctcacag atttgcattt cccacgcttt gagttcagat ggggggatca     8820

tgtctacctg cggggcgatg aagaaaacgg tttccggggt aggggagatc agctgggaag     8880

aaagcaggtt cctgagcagc tgcgacttac cgcagccggt gggcccgtaa atcacaccta     8940

ttaccgggtg caactggtag ttaagagagc tgcagctgcc gtcatccctg agcagggggg     9000

ccacttcgtt aagcatgtcc ctgactcgca tgttttccct gaccaaatcc gccagaaggc     9060

gctcgccgcc cagcgatagc agttcttgca aggaagcaaa gtttttcaac ggtttgagac     9120

cgtccgccgt aggcatgctt ttgagcgttt gaccaagcag ttccaggcgg tcccacagct     9180

cggtcacctg ctctacggca tctcgatcca gcatatctcc tcgtttcgcg ggttggggcg     9240

gctttcgctg tacggcagta gtcggtgctc gtccagacgg gccagggtca tgtctttcca     9300

cgggcgcagg gtcctcgtca gcgtagtctg ggtcacggtg aaggggtgcg ctccgggctg     9360

cgcgctggcc agggtgcgct tgaggctggt cctgctggtg ctgaagcgct gccggtcttc     9420

gccctgcgcg tcggccaggt agcatttgac catggtgtca tagtccagcc cctccgcggc     9480

gtggcccttg gcgcgcagct tgcccttgga ggaggcgccg cacgaggggc agtgcagact     9540

tttgagggcg tagagcttgg gcgcgagaaa taccgattcc ggggagtagg catccgcgcc     9600

gcaggccccg cagacggtct cgcattccac gagccaggtg agctctggcc gttcggggtc     9660

aaaaaccagg tttcccccat gctttttgat gcgtttctta cctctggttt ccatgagccg     9720

gtgtccacgc tcggtgacga aaaggctgtc cgtgtccccg tatacagact tgagaggcct     9780

gtcctcgagc ggtgttccgc ggtcctcctc gtatagaaac tcggaccact ctgagacaaa     9840

ggctcgcgtc caggccagca cgaaggaggc taagtgggag gggtagcggt cgttgtccac     9900

tagggggtcc actcgctcca gggtgtgaag acacatgtcg ccctcttcgg catcaaggaa     9960

ggtgattggt ttgtaggtgt aggccacgtg accgggtgtt cctgaagggg ggctataaaa    10020

gggggtgggg gcgcgttcgt cctcactctc ttccgcatcg ctgtctgcga gggccagctg    10080

ttggggtgag tactccctct gaaaagcggg catgacttct gcgctaagat tgtcagtttc    10140

caaaaacgag gaggatttga tattcacctg gcccgcggtg atgcctttga gggtggccgc    10200

atccatctgg tcagaaaaga caatcttttt gttgtcaagc ttggtggcaa acgacccgta    10260

gagggcgttg gacagcaact tggcgatgga gcgcagggtt tggtttttgt cgcgatcggc    10320

gcgctccttg gccgcgatgt ttagctgcac gtattcgcgc gcaacgcacc gccattcggg    10380

aaagacggtg gtgcgctcgt cgggcaccag gtgcacgcgc caaccgcggt tgtgcagggt    10440

gacaaggtca acgctggtgg ctacctctcc gcgtaggcgc tcgttggtcc agcagaggcg    10500

gccgcccttg cgcgagcaga atggcggtag ggggtctagc tgcgtctcgt ccggggggtc    10560

tgcgtccacg gtaaagaccc cgggcagcag gcgcgcgtcg aagtagtcta tcttgcatcc    10620

ttgcaagtct agcgcctgct gccatgcgcg ggcggcaagc gcgcgctcgt atgggttgag    10680

tgggggaccc catggcatgg ggtgggtgag cgcggaggcg tacatgccgc aaatgtcgta    10740

aacgtagagg ggctctctga gtattccaag atatgtaggg tagcatcttc caccgcggat    10800

gctggcgcgc acgtaatcgt atagttcgtg cgagggagcg aggaggtcgg gaccgaggtt    10860

gctacgggcg ggctgctctg ctcggaagac tatctgcctg aagatggcat gtgagttgga    10920

tgatatggtt ggacgctgga agacgttgaa gctggcgtct gtgagaccta ccgcgtcacg    10980

cacgaaggag gcgtaggagt cgcgcagctt gttgaccagc tcggcggtga cctgcacgtc    11040

tagggcgcag tagtccaggg tttccttgat gatgtcatac ttatcctgtc cctttttttt    11100

ccacagctcg cggttgagga caaactcttc gcggtctttc cagtactctt ggatcggaaa    11160

cccgtcggcc tccgaacggt aagagcctag catgtagaac tggttgacgg cctggtaggc    11220

gcagcatccc ttttctacgg gtagcgcgta tgcctgcgcg gccttccgga gcgaggtgtg    11280

ggtgagcgca aaggtgtccc tgaccatgac tttgaggtac tggtatttga agtcagtgtc    11340

gtcgcatccg ccctgctccc agagcaaaaa gtccgtgcgc tttttggaac gcggatttgg    11400

cagggcgaag gtgacatcgt tgaagagtat ctttcccgcg cgaggcataa agttgcgtgt    11460

gatgcggaag ggtcccggca cctcggaacg gttgttaatt acctgggcgg cgagcacgat    11520

ctcgtcaaag ccgttgatgt tgtggcccac aatgtaaagt tccaagaagc gcgggatgcc    11580

cttgatggaa ggcaattttt taagttcctc gtaggtgagc tcttcagggg agctgagccc    11640

gtgctctgaa agggcccagt ctgcaagatg agggttggaa gcgacgaatg agctccacag    11700

gtcacgggcc attagcattt gcaggtggtc gcgaaaggtc ctaaactggc gacctatggc    11760

cattttttct ggggtgatgc agtagaaggt aagcgggtct tgttcccagc ggtcccatcc    11820

aaggttcgcg gctaggtctc gcgcggcagt cactagaggc tcatctccgc cgaacttcat    11880

gaccagcatg aagggcacga gctgcttccc aaaggccccc atccaagtat aggtctctac    11940

atcgtaggtg acaaagagac gctcggtgcg aggatgcgag ccgatcggga agaactggat    12000

ctcccgccac caattggagg agtggctatt gatgtggtga aagtagaagt ccctgcgacg    12060

ggccgaacac tcgtgctggc ttttgtaaaa acgtgcgcag tactggcagc ggtgcacggg    12120

ctgtacatcc tgcacgaggt tgacctgacg accgcgcaca aggaagcaga gtgggaattt    12180

gagcccctcg cctggcgggt ttggctggtg gtcttctact tcggctgctt gtccttgacc    12240

gtctggctgc tcgaggggag ttacggtgga tcggaccacc acgccgcgcg agcccaaagt    12300

ccagatgtcc gcgcgcggcg gtcggagctt gatgacaaca tcgcgcagat gggagctgtc    12360

catggtctgg agctcccgcg gcgtcaggtc aggcgggagc tcctgcaggt ttacctcgca    12420

tagacgggtc agggcgcggg ctagatccag gtgataccta atttccaggg gctggttggt    12480

ggcggcgtcg atggcttgca agaggccgca tccccgcggc gcgactacgg taccgcgcgg    12540

cgggcggtgg gccgcggggg tgtccttgga tgatgcatct aaaagcggtg acgcgggcga    12600

gcccccggag gtaggggggg ctccggaccc gccgggagag ggggcagggg cacgtcggcg    12660

ccgcgcgcgg gcaggagctg gtgctgcgcg cgtaggttgc tggcgaacgc gacgacgcgg    12720

cggttgatct cctgaatctg gcgcctctgc gtgaagacga cgggcccggt gagcttgagc    12780

ctgaaagaga gttcgacaga atcaatttcg gtgtcgttga cggcggcctg gcgcaaaatc    12840

tcctgcacgt ctcctgagtt gtcttgatag gcgatctcgg ccatgaactg ctcgatctct    12900

tcctcctgga gatctccgcg tccggctcgc tccacggtgg cggcgaggtc gttggaaatg    12960

cgggccatga gctgcgagaa ggcgttgagg cctccctcgt tccagacgcg gctgtagacc    13020

acgccccctt cggcatcgcg ggcgcgcatg accacctgcg cgagattgag ctccacgtgc    13080

cgggcgaaga cggcgtagtt tcgcaggcgc tgaaagaggt agttgagggt ggtggcggtg    13140

tgttctgcca cgaagaagta cataacccag cgtcgcaacg tggattcgtt gatatccccc    13200

aaggcctcaa ggcgctccat ggcctcgtag aagtccacgg cgaagttgaa aaactgggag    13260

ttgcgcgccg acacggttaa ctcctcctcc agaagacgga tgagctcggc gacagtgtcg    13320

cgcacctcgc gctcaaaggc tacaggggcc tcttcttctt cttcaatctc ctcttccata    13380

agggcctccc cttcttcttc ttctggcggc ggtgggggag gggggacacg gcggcgacga    13440

cggcgcaccg ggaggcggtc gacaaagcgc tcgatcatct ccccgcggcg acggcgcatg    13500

gtctcggtga cggcgcggcc gttctcgcgg gggcgcagtt ggaagacgcc gcccgtcatg    13560

tcccggttat gggttggcgg ggggctgcca tgcggcaggg atacggcgct aacgatgcat    13620

ctcaacaatt gttgtgtagg tactccgccg ccgagggacc tgagcgagtc cgcatcgacc    13680

ggatcggaaa acctctcgag aaaggcgtct aaccagtcac agtcgcaagg taggctgagc    13740

accgtggcgg gcggcagcgg gcggcggtcg gggttgtttc tggcggaggt gctgctgatg    13800

atgtaattaa agtaggcggt cttgagacgg cggatggtcg acagaagcac catgtccttg    13860

ggtccggcct gctgaatgcg caggcggtcg gccatgcccc aggcttcgtt ttgacatcgg    13920

cgcaggtctt tgtagtagtc ttgcatgagc ctttctaccg gcacttcttc ttctccttcc    13980

tcttgtcctg catctcttgc atctatcgct gcggcggcgg cggagtttgg ccgtaggtgg    14040

cgccctcttc ctcccatgcg tgtgaccccg aagcccctca tcggctgaag cagggctagg    14100

tcggcgacaa cgcgctcggc taatatggcc tgctgcacct gcgtgagggt agactggaag    14160

tcatccatgt ccacaaagcg gtggtatgcg cccgtgttga tggtgtaagt gcagttggcc    14220

ataacggacc agttaacggt ctggtgaccc ggctgcgaga gctcggtgta cctgagacgc    14280

gagtaagccc tcgagtcaaa tacgtagtcg ttgcaagtcc gcaccaggta ctggtatccc    14340

accaaaaagt gcggcggcgg ctggcggtag aggggccagc gtagggtggc cggggctccg    14400

ggggcgagat cttccaacat aaggcgatga tatccgtaga tgtacctgga catccaggtg    14460

atgccggcgg cggtggtgga ggcgcgcgga aagtcgcgga cgcggttcca gatgttgcgc    14520

agcggcaaaa agtgctccat ggtcgggacg ctctggccgg tcaggcgcgc gcaatcgttg    14580

acgctctacc gtgcaaaagg agagcctgta agcgggcact cttccgtggt ctggtggata    14640

aattcgcaag ggtatcatgg cggacgaccg gggttcgagc cccgtatccg gccgtccgcc    14700

gtgatccatg cggttaccgc ccgcgtgtcg aacccaggtg tgcgacgtca gacaacgggg    14760

gagtgctcct tttggcttcc ttccaggcgc ggcggctgct gcgctagctt ttttggccac    14820

tggccgcgcg cagcgtaagc ggttaggctg gaaagcgaaa gcattaagtg gctcgctccc    14880

tgtagccgga gggttatttt ccaagggttg agtcgcggga cccccggttc gagtctcgga    14940

ccggccggac tgcggcgaac gggggtttgc ctccccgtca tgcaagaccc cgcttgcaaa    15000

ttcctccgga aacagggacg agcccctttt ttgcttttcc cagatgcatc cggtgctgcg    15060

gcagatgcgc ccccctcctc agcagcggca agagcaagag cagcggcaga catgcagggc    15120

accctcccct cctcctaccg cgtcaggagg ggcgacatcc gcggttgacg cggcagcaga    15180

tggtgattac gaacccccgc ggcgccgggc ccggcactac ctggacttgg aggagggcga    15240

gggcctggcg cggctaggag cgccctctcc tgagcggtac ccaagggtgc agctgaagcg    15300

tgatacgcgt gaggcgtacg tgccgcggca gaacctgttt cgcgaccgcg agggagagga    15360

gcccgaggag atgcgggatc gaaagttcca cgcagggcgc gagctgcggc atggcctgaa    15420

tcgcgagcgg ttgctgcgcg aggaggactt tgagcccgac gcgcgaaccg ggattagtcc    15480

cgcgcgcgca cacgtggcgg ccgccgacct ggtaaccgca tacgagcaga cggtgaacca    15540

ggagattaac tttcaaaaaa gctttaacaa ccacgtgcgt acgcttgtgg cgcgcgagga    15600

ggtggctata ggactgatgc atctgtggga ctttgtaagc gcgctggagc aaaacccaaa    15660

tagcaagccg ctcatggcgc agctgttcct tatagtgcag cacagcaggg acaacgaggc    15720

attcagggat gcgctgctaa acatagtaga gcccgagggc cgctggctgc tcgatttgat    15780

aaacatcctg cagagcatag tggtgcagga gcgcagcttg agcctggctg acaaggtggc    15840

cgccatcaac tattccatgc ttagcctggg caagttttac gcccgcaaga tataccatac    15900

cccttacgtt cccatagaca aggaggtaaa gatcgagggg ttctacatgc gcatggcgct    15960

gaaggtgctt accttgagcg acgacctggg cgtttatcgc aacgagcgca tccacaaggc    16020

cgtgagcgtg agccggcggc gcgagctcag cgaccgcgag ctgatgcaca gcctgcaaag    16080

ggccctggct ggcacgggca gcggcgatag agaggccgag tcctactttg acgcgggcgc    16140

tgacctgcgc tgggccccaa gccgacgcgc cctggaggca gctggggccg gacctgggct    16200

ggcggtggca cccgcgcgcg ctggcaacgt cggcggcgtg gaggaatatg acgaggacga    16260

tgagtacgag ccagaggacg gcgagtacta agcggtgatg tttctgatca gatgatgcaa    16320

gacgcaacgg acccggcggt gcgggcggcg ctgcagagcc agccgtccgg ccttaactcc    16380

acggacgact ggcgccaggt catggaccgc atcatgtcgc tgactgcgcg caatcctgac    16440

gcgttccggc agcagccgca ggccaaccgg ctctccgcaa ttctggaagc ggtggtcccg    16500

gcgcgcgcaa accccacgca cgagaaggtg ctggcgatcg taaacgcgct ggccgaaaac    16560

agggccatcc ggcccgacga ggccggcctg gtctacgacg cgctgcttca gcgcgtggct    16620

cgttacaaca gcggcaacgt gcagaccaac ctggaccggc tggtggggga tgtgcgcgag    16680

gccgtggcgc agcgtgagcg cgcgcagcag cagggcaacc tgggctccat ggttgcacta    16740

aacgccttcc tgagtacaca gcccgccaac gtgccgcggg gacaggagga ctacaccaac    16800

tttgtgagcg cactgcggct aatggtgact gagacaccgc aaagtgaggt gtaccagtct    16860

gggccagact attttttcca gaccagtaga caaggcctgc agaccgtaaa cctgagccag    16920

gctttcaaaa acttgcaggg gctgtggggg gtgcgggctc ccacaggcga ccgcgcgacc    16980

gtgtctagct tgctgacgcc caactcgcgc ctgttgctgc tgctaatagc gcccttcacg    17040

gacagtggca gcgtgtcccg ggacacatac ctaggtcact tgctgacact gtaccgcgag    17100

gccataggtc aggcgcatgt ggacgagcat actttccagg agattacaag tgtcagccgc    17160

gcgctggggc aggaggacac gggcagcctg gaggcaaccc taaactacct gctgaccaac    17220

cggcggcaga agatcccctc gttgcacagt ttaaacagcg aggaggagcg cattttgcgc    17280

tacgtgcagc agagcgtgag ccttaacctg atgcgcgacg gggtaacgcc cagcgtggcg    17340

ctggacatga ccgcgcgcaa catggaaccg ggcatgtatg cctcaaaccg gccgtttatc    17400

aaccgcctaa tggactactt gcatcgcgcg gccgccgtga accccgagta tttcaccaat    17460

gccatcttga acccgcactg gctaccgccc cctggtttct acaccggggg attcgaggtg    17520

cccgagggta acgatggatt cctctgggac gacatagacg acagcgtgtt ttccccgcaa    17580

ccgcagaccc tgctagagtt gcaacagcgc gagcaggcag aggcggcgct gcgaaaggaa    17640

agcttccgca ggccaagcag cttgtccgat ctaggcgctg cggccccgcg gtcagatgct    17700

agtagcccat ttccaagctt gatagggtct cttaccagca ctcgcaccac ccgcccgcgc    17760

ctgctgggcg aggaggagta cctaaacaac tcgctgctgc agccgcagcg cgaaaaaaac    17820

ctgcctccgg catttcccaa caacgggata gagagcctag tggacaagat gagtagatgg    17880

aagacgtacg cgcaggagca cagggacgtg ccaggcccgc gcccgcccac ccgtcgtcaa    17940

aggcacgacc gtcagcgggg tctggtgtgg gaggacgatg actcggcaga cgacagcagc    18000

gtcctggatt tgggagggag tggcaacccg tttgcgcacc ttcgccccag gctggggaga    18060

atgttttaaa aaaaaaaaag catgatgcaa aataaaaaac tcaccaaggc catggcaccg    18120

agcgttggtt ttcttgtatt ccccttagta tgcggcgcgc ggcgatgtat gaggaaggtc    18180

ctcctccctc ctacgagagt gtggtgagcg cggcgccagt ggcggcggcg ctgggttctc    18240

ccttcgatgc tcccctggac ccgccgtttg tgcctccgcg gtacctgcgg cctaccgggg    18300

ggagaaacag catccgttac tctgagttgg cacccctatt cgacaccacc cgtgtgtacc    18360

tggtggacaa caagtcaacg gatgtggcat ccctgaacta ccagaacgac cacagcaact    18420

ttctgaccac ggtcattcaa aacaatgact acagcccggg ggaggcaagc acacagacca    18480

tcaatcttga cgaccggtcg cactggggcg gcgacctgaa aaccatcctg cataccaaca    18540

tgccaaatgt gaacgagttc atgtttacca ataagtttaa ggcgcgggtg atggtgtcgc    18600

gcttgcctac taaggacaat caggtggagc tgaaatacga gtgggtggag ttcacgctgc    18660

ccgagggcaa ctactccgag accatgacca tagaccttat gaacaacgcg atcgtggagc    18720

actacttgaa agtgggcaga cagaacgggg ttctggaaag cgacatcggg gtaaagtttg    18780

acacccgcaa cttcagactg gggtttgacc ccgtcactgg tcttgtcatg cctggggtat    18840

atacaaacga agccttccat ccagacatca ttttgctgcc aggatgcggg gtggacttca    18900

cccacagccg cctgagcaac ttgttgggca tccgcaagcg gcaacccttc caggagggct    18960

ttaggatcac ctacgatgat ctggagggtg gtaacattcc cgcactgttg gatgtggacg    19020

cctaccaggc gagcttgaaa gatgacaccg aacagggcgg gggtggcgca ggcggcagca    19080

acagcagtgg cagcggcgcg gaagagaact ccaacgcggc agccgcggca atgcagccgg    19140

tggaggacat gaacgatcat gccattcgcg gcgacacctt tgccacacgg gctgaggaga    19200

agcgcgctga ggccgaagca gcggccgaag ctgccgcccc cgctgcgcaa cccgaggtcg    19260

agaagcctca gaagaaaccg gtgatcaaac ccctgacaga ggacagcaag aaacgcagtt    19320

acaacctaat aagcaatgac agcaccttca cccagtaccg cagctggtac cttgcataca    19380

actacggcga ccctcagacc ggaatccgct catggaccct gctttgcact cctgacgtaa    19440

cctgcggctc ggagcaggtc tactggtcgt tgccagacat gatgcaagac cccgtgacct    19500

tccgctccac gcgccagatc agcaactttc cggtggtggg cgccgagctg ttgcccgtgc    19560

actccaagag cttctacaac gaccaggccg tctactccca actcatccgc cagtttacct    19620

ctctgaccca cgtgttcaat cgctttcccg agaaccagat tttggcgcgc ccgccagccc    19680

ccaccatcac caccgtcagt gaaaacgttc ctgctctcac agatcacggg acgctaccgc    19740

tgcgcaacag catcggagga gtccagcgag tgaccattac tgacgccaga cgccgcacct    19800

gcccctacgt ttacaaggcc ctgggcatag tctcgccgcg cgtcctatcg agccgcactt    19860

tttgagcaag catgtccatc cttatatcgc ccagcaataa cacaggctgg ggcctgcgct    19920

tcccaagcaa gatgtttggc ggggccaaga agcgctccga ccaacaccca gtgcgcgtgc    19980

gcgggcacta ccgcgcgccc tggggcgcgc acaaacgcgg ccgcactggg cgcaccaccg    20040

tcgatgacgc catcgacgcg gtggtggagg aggcgcgcaa ctacacgccc acgccgccac    20100

cagtgtccac agtggacgcg gccattcaga ccgtggtgcg cggagcccgg cgctatgcta    20160

aaatgaagag acggcggagg cgcgtagcac gtcgccaccg ccgccgaccc ggcactgccg    20220

cccaacgcgc ggcggcggcc ctgcttaacc gcgcacgtcg caccggccga cgggcggcca    20280

tgcgggccgc tcgaaggctg gccgcgggta ttgtcactgt gccccccagg tccaggcgac    20340

gagcggccgc cgcagcagcc gcggccatta gtgctatgac tcagggtcgc aggggcaacg    20400

tgtattgggt gcgcgactcg gttagcggcc tgcgcgtgcc cgtgcgcacc cgccccccgc    20460

gcaactagat tgcaagaaaa aactacttag actcgtactg ttgtatgtat ccagcggcgg    20520

cggcgcgcaa cgaagctatg tccaagcgca aaatcaaaga agagatgctc caggtcatcg    20580

cgccggagat ctatggcccc ccgaagaagg aagagcagga ttacaagccc cgaaagctaa    20640

agcgggtcaa aaagaaaaag aaagatgatg atgatgaact tgacgacgag gtggaactgc    20700

tgcacgctac cgcgcccagg cgacgggtac agtggaaagg tcgacgcgta aaacgtgttt    20760

tgcgacccgg caccaccgta gtctttacgc ccggtgagcg ctccacccgc acctacaagc    20820

gcgtgtatga tgaggtgtac ggcgacgagg acctgcttga gcaggccaac gagcgcctcg    20880

gggagtttgc ctacggaaag cggcataagg acatgctggc gttgccgctg gacgagggca    20940

acccaacacc tagcctaaag cccgtaacac tgcagcaggt gctgcccgcg cttgcaccgt    21000

ccgaagaaaa gcgcggccta aagcgcgagt ctggtgactt ggcacccacc gtgcagctga    21060

tggtacccaa gcgccagcga ctggaagatg tcttggaaaa aatgaccgtg gaacctgggc    21120

tggagcccga ggtccgcgtg cggccaatca agcaggtggc gccgggactg ggcgtgcaga    21180

ccgtggacgt tcagataccc actaccagta gcaccagtat tgccaccgcc acagagggca    21240

tggagacaca aacgtccccg gttgcctcag cggtggcgga tgccgcggtg caggcggtcg    21300

ctgcggccgc gtccaagacc tctacggagg tgcaaacgga cccgtggatg tttcgcgttt    21360

cagccccccg gcgcccgcgc ggttcgagga agtacggcgc cgccagcgcg ctactgcccg    21420

aatatgccct acatccttcc attgcgccta cccccggcta tcgtggctac acctaccgcc    21480

ccagaagacg agcaactacc cgacgccgaa ccaccactgg aacccgccgc cgccgtcgcc    21540

gtcgccagcc cgtgctggcc ccgatttccg tgcgcagggt ggctcgcgaa ggaggcagga    21600

ccctggtgct gccaacagcg cgctaccacc ccagcatcgt ttaaaagccg gtctttgtgg    21660

ttcttgcaga tatggccctc acctgccgcc tccgtttccc ggtgccggga ttccgaggaa    21720

gaatgcaccg taggaggggc atggccggcc acggcctgac gggcggcatg cgtcgtgcgc    21780

accaccggcg gcggcgcgcg tcgcaccgtc gcatgcgcgg cggtatcctg cccctcctta    21840

ttccactgat cgccgcggcg attggcgccg tgcccggaat tgcatccgtg gccttgcagg    21900

cgcagagaca ctgattaaaa acaagttgca tgtggaaaaa tcaaaataaa aagtctggac    21960

tctcacgctc gcttggtcct gtaactattt tgtagaatgg aagacatcaa ctttgcgtct    22020

ctggccccgc gacacggctc gcgcccgttc atgggaaact ggcaagatat cggcaccagc    22080

aatatgagcg gtggcgcctt cagctggggc tcgctgtgga gcggcattaa aaatttcggt    22140

tccaccgtta agaactatgg cagcaaggcc tggaacagca gcacaggcca gatgctgagg    22200

gataagttga aagagcaaaa tttccaacaa aaggtggtag atggcctggc ctctggcatt    22260

agcggggtgg tggacctggc caaccaggca gtgcaaaata agattaacag taagcttgat    22320

ccccgccctc ccgtagagga gcctccaccg gccgtggaga cagtgtctcc agaggggcgt    22380

ggcgaaaagc gtccgcgccc cgacagggaa gaaactctgg tgacgcaaat agacgagcct    22440

ccctcgtacg aggaggcact aaagcaaggc ctgcccacca cccgtcccat cgcgcccatg    22500

gctaccggag tgctgggcca gcacacaccc gtaacgctgg acctgcctcc ccccgccgac    22560

acccagcaga aacctgtgct gccaggcccg accgccgttg ttgtaacccg tcctagccgc    22620

gcgtccctgc gccgcgccgc cagcggtccg cgatcgttgc ggcccgtagc cagtggcaac    22680

tggcaaagca cactgaacag catcgtgggt ctgggggtgc aatccctgaa gcgccgacga    22740

tgcttctgaa tagctaacgt gtcgtatgtg tgtcatgtat gcgtccatgt cgccgccaga    22800

ggagctgctg agccgccgcg cgcccgcttt ccaagatggc taccccttcg atgatgccgc    22860

agtggtctta catgcacatc tcgggccagg acgcctcgga gtacctgagc cccgggctgg    22920

tgcagtttgc ccgcgccacc gagacgtact tcagcctgaa taacaagttt agaaacccca    22980

cggtggcgcc tacgcacgac gtgaccacag accggtccca gcgtttgacg ctgcggttca    23040

tccctgtgga ccgtgaggat actgcgtact cgtacaaggc gcggttcacc ctagctgtgg    23100

gtgataaccg tgtgctggac atggcttcca cgtactttga catccgcggc gtgctggaca    23160

ggggccctac ttttaagccc tactctggca ctgcctacaa cgccctggct cccaagggtg    23220

ccccaaatcc ttgcgaatgg gatgaagctg ctactgctct tgaaataaac ctagaagaag    23280

aggacgatga caacgaagac gaagtagacg agcaagctga gcagcaaaaa actcacgtat    23340

ttgggcaggc gccttattct ggtataaata ttacaaagga gggtattcaa ataggtgtcg    23400

aaggtcaaac acctaaatat gccgataaaa catttcaacc tgaacctcaa ataggagaat    23460

ctcagtggta cgaaactgaa attaatcatg cagctgggag agtccttaaa aagactaccc    23520

caatgaaacc atgttacggt tcatatgcaa aacccacaaa tgaaaatgga gggcaaggca    23580

ttcttgtaaa gcaacaaaat ggaaagctag aaagtcaagt ggaaatgcaa tttttctcaa    23640

ctactgaggc gaccgcaggc aatggtgata acttgactcc taaagtggta ttgtacagtg    23700

aagatgtaga tatagaaacc ccagacactc atatttctta catgcccact attaaggaag    23760

gtaactcacg agaactaatg ggccaacaat ctatgcccaa caggcctaat tacattgctt    23820

ttagggacaa ttttattggt ctaatgtatt acaacagcac gggtaatatg ggtgttctgg    23880

cgggccaagc atcgcagttg aatgctgttg tagatttgca agacagaaac acagagcttt    23940

cataccagct tttgcttgat tccattggtg atagaaccag gtacttttct atgtggaatc    24000

aggctgttga cagctatgat ccagatgtta gaattattga aaatcatgga actgaagatg    24060

aacttccaaa ttactgcttt ccactgggag gtgtgattaa tacagagact cttaccaagg    24120

taaaacctaa aacaggtcag gaaaatggat gggaaaaaga tgctacagaa ttttcagata    24180

aaaatgaaat aagagttgga aataattttg ccatggaaat caatctaaat gccaacctgt    24240

ggagaaattt cctgtactcc aacatagcgc tgtatttgcc cgacaagcta aagtacagtc    24300

cttccaacgt aaaaatttct gataacccaa acacctacga ctacatgaac aagcgagtgg    24360

tggctcccgg gttagtggac tgctacatta accttggagc acgctggtcc cttgactata    24420

tggacaacgt caacccattt aaccaccacc gcaatgctgg cctgcgctac cgctcaatgt    24480

tgctgggcaa tggtcgctat gtgcccttcc acatccaggt gcctcagaag ttctttgcca    24540

ttaaaaacct ccttctcctg ccgggctcat acacctacga gtggaacttc aggaaggatg    24600

ttaacatggt tctgcagagc tccctaggaa atgacctaag ggttgacgga gccagcatta    24660

agtttgatag catttgcctt tacgccacct tcttccccat ggcccacaac accgcctcca    24720

cgcttgaggc catgcttaga aacgacacca acgaccagtc ctttaacgac tatctctccg    24780

ccgccaacat gctctaccct atacccgcca acgctaccaa cgtgcccata tccatcccct    24840

cccgcaactg ggcggctttc cgcggctggg ccttcacgcg ccttaagact aaggaaaccc    24900

catcactggg ctcgggctac gacccttatt acacctactc tggctctata ccctacctag    24960

atggaacctt ttacctcaac cacaccttta agaaggtggc cattaccttt gactcttctg    25020

tcagctggcc tggcaatgac cgcctgctta cccccaacga gtttgaaatt aagcgctcag    25080

ttgacgggga gggttacaac gttgcccagt gtaacatgac caaagactgg ttcctggtac    25140

aaatgctagc taactacaac attggctacc agggcttcta tatcccagag agctacaagg    25200

accgcatgta ctccttcttt agaaacttcc agcccatgag ccgtcaggtg gtggatgata    25260

ctaaatacaa ggactaccaa caggtgggca tcctacacca acacaacaac tctggatttg    25320

ttggctacct tgcccccacc atgcgcgaag gacaggccta ccctgctaac ttcccctatc    25380

cgcttatagg caagaccgca gttgacagca ttacccagaa aaagtttctt tgcgatcgca    25440

ccctttggcg catcccattc tccagtaact ttatgtccat gggcgcactc acagacctgg    25500

gccaaaacct tctctacgcc aactccgccc acgcgctaga catgactttt gaggtggatc    25560

ccatggacga gcccaccctt ctttatgttt tgtttgaagt ctttgacgtg gtccgtgtgc    25620

accggccgca ccgcggcgtc atcgaaaccg tgtacctgcg cacgcccttc tcggccggca    25680

acgccacaac ataaagaagc aagcaacatc aacaacagct gccgccatgg gctccagtga    25740

gcaggaactg aaagccattg tcaaagatct tggttgtggg ccatattttt tgggcaccta    25800

tgacaagcgc tttccaggct ttgtttctcc acacaagctc gcctgcgcca tagtcaatac    25860

ggccggtcgc gagactgggg gcgtacactg gatggccttt gcctggaacc cgcactcaaa    25920

aacatgctac ctctttgagc cctttggctt ttctgaccag cgactcaagc aggtttacca    25980

gtttgagtac gagtcactcc tgcgccgtag cgccattgct tcttcccccg accgctgtat    26040

aacgctggaa aagtccaccc aaagcgtaca ggggcccaac tcggccgcct gtggactatt    26100

ctgctgcatg tttctccacg cctttgccaa ctggccccaa actcccatgg atcacaaccc    26160

caccatgaac cttattaccg gggtacccaa ctccatgctc aacagtcccc aggtacagcc    26220

caccctgcgt cgcaaccagg aacagctcta cagcttcctg gagcgccact cgccctactt    26280

ccgcagccac agtgcgcaga ttaggagcgc cacttctttt tgtcacttga aaaacatgta    26340

aaaataatgt actagagaca ctttcaataa aggcaaatgc ttttatttgt acactctcgg    26400

gtgattattt acccccaccc ttgccgtctg cgccgtttaa aaatcaaagg ggttctgccg    26460

cgcatcgcta tgcgccactg gcagggacac gttgcgatac tggtgtttag tgctccactt    26520

aaactcaggc acaaccatcc gcggcagctc ggtgaagttt tcactccaca ggctgcgcac    26580

catcaccaac gcgtttagca ggtcgggcgc cgatatcttg aagtcgcagt tggggcctcc    26640

gccctgcgcg cgcgagttgc gatacacagg gttgcagcac tggaacacta tcagcgccgg    26700

gtggtgcacg ctggccagca cgctcttgtc ggagatcaga tccgcgtcca ggtcctccgc    26760

gttgctcagg gcgaacggag tcaactttgg tagctgcctt cccaaaaagg gcgcgtgccc    26820

aggctttgag ttgcactcgc accgtagtgg catcaaaagg tgaccgtgcc cggtctgggc    26880

gttaggatac agcgcctgca taaaagcctt gatctgctta aaagccacct gagcctttgc    26940

gccttcagag aagaacatgc cgcaagactt gccggaaaac tgattggccg gacaggccgc    27000

gtcgtgcacg cagcaccttg cgtcggtgtt ggagatctgc accacatttc ggccccaccg    27060

gttcttcacg atcttggcct tgctagactg ctccttcagc gcgcgctgcc cgttttcgct    27120

cgtcacatcc atttcaatca cgtgctcctt atttatcata atgcttccgt gtagacactt    27180

aagctcgcct tcgatctcag cgcagcggtg cagccacaac gcgcagcccg tgggctcgtg    27240

atgcttgtag gtcacctctg caaacgactg caggtacgcc tgcaggaatc gccccatcat    27300

cgtcacaaag gtcttgttgc tggtgaaggt cagctgcaac ccgcggtgct cctcgttcag    27360

ccaggtcttg catacggccg ccagagcttc cacttggtca ggcagtagtt tgaagttcgc    27420

ctttagatcg ttatccacgt ggtacttgtc catcagcgcg cgcgcagcct ccatgccctt    27480

ctcccacgca gacacgatcg gcacactcag cgggttcatc accgtaattt cactttccgc    27540

ttcgctgggc tcttcctctt cctcttgcgt ccgcatacca cgcgccactg ggtcgtcttc    27600

attcagccgc cgcactgtgc gcttacctcc tttgccatgc ttgattagca ccggtgggtt    27660

gctgaaaccc accatttgta gcgccacatc ttctctttct tcctcgctgt ccacgattac    27720

ctctggtgat ggcgggcgct cgggcttggg agaagggcgc ttctttttct tcttgggcgc    27780

aatggccaaa tccgccgccg aggtcgatgg ccgcgggctg ggtgtgcgcg gcaccagcgc    27840

gtcttgtgat gagtcttcct cgtcctcgga ctcgatacgc cgcctcatcc gcttttttgg    27900

gggcgcccgg ggaggcggcg gcgacgggga cggggacgac acgtcctcca tggttggggg    27960

acgtcgcgcc gcaccgcgtc cgcgctcggg ggtggtttcg cgctgctcct cttcccgact    28020

ggccatttcc ttctcctata ggcagaaaaa gatcatggag tcagtcgaga agaaggacag    28080

cctaaccgcc ccctctgagt tcgccaccac cgcctccacc gatgccgcca acgcgcctac    28140

caccttcccc gtcgaggcac ccccgcttga ggaggaggaa gtgattatcg agcaggaccc    28200

aggttttgta agcgaagacg acgaggaccg ctcagtacca acagaggata aaaagcaaga    28260

ccaggacaac gcagaggcaa acgaggaaca agtcgggcgg ggggacgaaa ggcatggcga    28320

ctacctagat gtgggagacg acgtgctgtt gaagcatctg cagcgccagt gcgccattat    28380

ctgcgacgcg ttgcaagagc gcagcgatgt gcccctcgcc atagcggatg tcagccttgc    28440

ctacgaacgc cacctattct caccgcgcgt accccccaaa cgccaagaaa acggcacatg    28500

cgagcccaac ccgcgcctca acttctaccc cgtatttgcc gtgccagagg tgcttgccac    28560

ctatcacatc tttttccaaa actgcaagat acccctatcc tgccgtgcca accgcagccg    28620

agcggacaag cagctggcct tgcggcaggg cgctgtcata cctgatatcg cctcgctcaa    28680

cgaagtgcca aaaatctttg agggtcttgg acgcgacgag aagcgcgcgg caaacgctct    28740

gcaacaggaa aacagcgaaa atgaaagtca ctctggagtg ttggtggaac tcgagggtga    28800

caacgcgcgc ctagccgtac taaaacgcag catcgaggtc acccactttg cctacccggc    28860

acttaaccta ccccccaagg tcatgagcac agtcatgagt gagctgatcg tgcgccgtgc    28920

gcagcccctg gagagggatg caaatttgca agaacaaaca gaggagggcc tacccgcagt    28980

tggcgacgag cagctagcgc gctggcttca aacgcgcgag cctgccgact tggaggagcg    29040

acgcaaacta atgatggccg cagtgctcgt taccgtggag cttgagtgca tgcagcggtt    29100

ctttgctgac ccggagatgc agcgcaagct agaggaaaca ttgcactaca cctttcgaca    29160

gggctacgta cgccaggcct gcaagatctc caacgtggag ctctgcaacc tggtctccta    29220

ccttggaatt ttgcacgaaa accgccttgg gcaaaacgtg cttcattcca cgctcaaggg    29280

cgaggcgcgc cgcgactacg tccgcgactg cgtttactta tttctatgct acacctggca    29340

gacggccatg ggcgtttggc agcagtgctt ggaggagtgc aacctcaagg agctgcagaa    29400

actgctaaag caaaacttga aggacctatg gacggccttc aacgagcgct ccgtggccgc    29460

gcacctggcg gacatcattt tccccgaacg cctgcttaaa accctgcaac agggtctgcc    29520

agacttcacc agtcaaagca tgttgcagaa ctttaggaac tttatcctag agcgctcagg    29580

aatcttgccc gccacctgct gtgcacttcc tagcgacttt gtgcccatta agtaccgcga    29640

atgccctccg ccgctttggg gccactgcta ccttctgcag ctagccaact accttgccta    29700

ccactctgac ataatggaag acgtgagcgg tgacggtcta ctggagtgtc actgtcgctg    29760

caacctatgc accccgcacc gctccctggt ttgcaattcg cagctgctta acgaaagtca    29820

aattatcggt acctttgagc tgcagggtcc ctcgcctgac gaaaagtccg cggctccggg    29880

gttgaaactc actccggggc tgtggacgtc ggcttacctt cgcaaatttg tacctgagga    29940

ctaccacgcc cacgagatta ggttctacga agaccaatcc cgcccgccaa atgcggagct    30000

taccgcctgc gtcattaccc agggccacat tcttggccaa ttgcaagcca tcaacaaagc    30060

ccgccaagag tttctgctac gaaagggacg gggggtttac ttggaccccc agtccggcga    30120

ggagctcaac ccaatccccc cgccgccgca gccctatcag cagcagccgc gggcccttgc    30180

ttcccaggat ggcacccaaa aagaagctgc agctgccgcc gccacccacg gacgaggagg    30240

aatactggga cagtcaggca gaggaggttt tggacgagga ggaggaggac atgatggaag    30300

actgggagag cctagacgag gaagcttccg aggtcgaaga ggtgtcagac gaaacaccgt    30360

caccctcggt cgcattcccc tcgccggcgc cccagaaatc ggcaaccggt tccagcatgg    30420

ctacaacctc cgctcctcag gcgccgccgg cactgcccgt tcgccgaccc aaccgtagat    30480

gggacaccac tggaaccagg gccggtaagt ccaagcagcc gccgccgtta gcccaagagc    30540

aacaacagcg ccaaggctac cgctcatggc gcgggcacaa gaacgccata gttgcttgct    30600

tgcaagactg tgggggcaac atctccttcg cccgccgctt tcttctctac catcacggcg    30660

tggccttccc ccgtaacatc ctgcattact accgtcatct ctacagccca tactgcaccg    30720

gcggcagcgg cagcggcagc aacagcagcg gccacacaga agcaaaggcg accggatagc    30780

aagactctga caaagcccaa gaaatccaca gcggcggcag cagcaggagg aggagcgctg    30840

cgtctggcgc ccaacgaacc cgtatcgacc cgcgagctta gaaacaggat ttttcccact    30900

ctgtatgcta tatttcaaca gagcaggggc caagaacaag agctgaaaat aaaaaacagg    30960

tctctgcgat ccctcacccg cagctgcctg tatcacaaaa gcgaagatca gcttcggcgc    31020

acgctggaag acgcggaggc tctcttcagt aaatactgcg cgctgactct taaggactag    31080

tttcgcgccc tttctcaaat ttaagcgcga aaactacgtc atctccagcg gccacacccg    31140

gcgccagcac ctgtcgtcag cgccattatg agcaaggaaa ttcccacgcc ctacatgtgg    31200

agttaccagc cacaaatggg acttgcggct ggagctgccc aagactactc aacccgaata    31260

aactacatga gcgcgggacc ccacatgata tcccgggtca acggaatccg cgcccaccga    31320

aaccgaattc tcttggaaca ggcggctatt accaccacac ctcgtaataa ccttaatccc    31380

cgtagttggc ccgctgccct ggtgtaccag gaaagtcccg ctcccaccac tgtggtactt    31440

cccagagacg cccaggccga agttcagatg actaactcag gggcgcagct tgcgggcggc    31500

tttcgtcaca gggtgcggtc gcccgggcag ggtataactc acctgacaat cagagggcga    31560

ggtattcagc tcaacgacga gtcggtgagc tcctcgcttg gtctccgtcc ggacgggaca    31620

tttcagatcg gcggcgccgg ccgtccttca ttcacgcctc gtcaggcaat cctaactctg    31680

cagacctcgt cctctgagcc gcgctctgga ggcattggaa ctctgcaatt tattgaggag    31740

tttgtgccat cggtctactt taaccccttc tcgggacctc ccggccacta tccggatcaa    31800

tttattccta actttgacgc ggtaaaggac tcggcggacg gctacgactg aatgttaagt    31860

ggagaggcag agcaactgcg cctgaaacac ctggtccact gtcgccgcca caagtgcttt    31920

gcccgcgact ccggtgagtt ttgctacttt gaattgcccg aggatcatat cgagggcccg    31980

gcgcacggcg tccggcttac cgcccaggga gagcttgccc gtagcctgat tcgggagttt    32040

acccagcgcc ccctgctagt tgagcgggac aggggaccct gtgttctcac tgtgatttgc    32100

aactgtccta accttggatt acatcaagat ctttgttgcc atctctgtgc tgagtataat    32160

aaatacagaa attaaaatat actggggctc ctatcgccat cctgtaaacg ccaccgtctt    32220

cacccgccca agcaaaccaa ggcgaacctt acctggtact tttaacatct ctccctctgt    32280

gatttacaac agtttcaacc cagacggagt gagtctacga gagaacctct ccgagctcag    32340

ctactccatc agaaaaaaca ccaccctcct tacctgccgg gaacgtacga gtgcgtcacc    32400

ggccgctgca ccacacctac cgcctgaccg taaaccagac tttttccgga cagacctcaa    32460

taactctgtt taccagaaca ggaggtgagc ttagaaaacc cttagggtat taggccaaag    32520

gcgcagctac tgtggggttt atgaacaatt caagcaactc tacgggctat tctaattcag    32580

gtttctctag ggttggggtt attctctgtc ttgtgattct ctttattctt atactaacgc    32640

ttctctgcct aaggctcgcc gcctgctgtg tgcacatttg catttattgt cagcttttta    32700

aacgctgggg tcgccaccca agatgattag gtacataatc ctaggtttac tcacccttgc    32760

gtcagcccac ggtaccaccc aaaaggtgga ttttaaggag ccagcctgta atgttacatt    32820

cgcagctgaa gctaatgagt gcaccactct tataaaatgc accacagaac atgaaaagct    32880

gcttattcgc cacaaaaaca aaattggcaa gtatgctgtt tatgctattt ggcagccagg    32940

tgacactaca gagtataatg ttacagtttt ccagggtaaa agtcataaaa cttttatgta    33000

tacttttcca ttttatgaaa tgtgcgacat taccatgtac atgagcaaac agtataagtt    33060

gtggccccca caaaattgtg tggaaaacac tggcactttc tgctgcactg ctatgctaat    33120

tacagtgctc gctttggtct gtaccctact ctatattaaa tacaaaagca gacgcagctt    33180

tattgaggaa aagaaaatgc cttaataaaa aaaaataata aagcatcact tacttaaaat    33240

cagttagcaa atttctgtcc agtttattca gcagcacctc cttgccctcc tcccagctct    33300

ggtattgcag cttcctcctg gctgcaaact ttctccacaa tctaaatgga atgtcagttt    33360

cctcctgttc ctgtccatcc gcacccacta tcttcatgtt gttgcagatg aagcgcgcaa    33420

gaccgtctga agataccttc aaccccgtgt atccatatga cacggaaacc ggtcctccaa    33480

ctgtgccttt tcttactcct ccctttgtat cccccaatgg gtttcaagag agtccccctg    33540

gggtactctc tttgcgccta tccgaacctc tagttacctc caatggcatg cttgcgctca    33600

aaatgggcaa cggcctctct ctggacgagg ccggcaacct tacctcccaa aatgtaacca    33660

ctgtgagccc acctctcaaa aaaaccaagt caaacataaa cctggaaata tctgcacccc    33720

tcacagttac ctcagaagcc ctaactgtgg ctgccgccgc acctctaatg gtcgcgggca    33780

acacactcac catgcaatca caggccccgc taaccgtgca cgactccaaa cttagcattg    33840

ccacccaagg acccctcaca gtgtcagaag gaaagctagc cctgcaaaca tcaggccccc    33900

tcaccaccac cgatagcagt acccttacta tcactgcctc accccctcta actactgcca    33960

ctggtagctt gggcattgac ttgaaagagc ccatttatac acaaaatgga aaactaggac    34020

taaagtacgg ggctcctttg catgtaacag acgacctaaa cactttgacc gtagcaactg    34080

gtccaggtgt gactattaat aatacttcct tgcaaactaa agttactgga gccttgggtt    34140

ttgattcaca aggcaatatg caacttaatg tagcaggagg actaaggatt gattctcaaa    34200

acagacgcct tatacttgat gttagttatc cgtttgatgc tcaaaaccaa ctaaatctaa    34260

gactaggaca gggccctctt tttataaact cagcccacaa cttggatatt aactacaaca    34320

aaggccttta cttgtttaca gcttcaaaca attccaaaaa gcttgaggtt aacctaagca    34380

ctgccaaggg gttgatgttt gacgctacag ccatagccat taatgcagga gatgggcttg    34440

aatttggttc acctaatgca ccaaacacaa atcccctcaa aacaaaaatt ggccatggcc    34500

tagaatttga ttcaaacaag gctatggttc ctaaactagg aactggcctt agttttgaca    34560

gcacaggtgc cattacagta ggaaacaaaa ataatgataa gctaactttg tggaccacac    34620

cagctccatc tcctaactgt agactaaatg cagagaaaga tgctaaactc actttggtct    34680

taacaaaatg tggcagtcaa atacttgcta cagtttcagt tttggctgtt aaaggcagtt    34740

tggctccaat atctggaaca gttcaaagtg ctcatcttat tataagattt gacgaaaatg    34800

gagtgctact aaacaattcc ttcctggacc cagaatattg gaactttaga aatggagatc    34860

ttactgaagg cacagcctat acaaacgctg ttggatttat gcctaaccta tcagcttatc    34920

caaaatctca cggtaaaact gccaaaagta acattgtcag tcaagtttac ttaaacggag    34980

acaaaactaa acctgtaaca ctaaccatta cactaaacgg tacacaggaa acaggagaca    35040

caactccaag tgcatactct atgtcatttt catgggactg gtctggccac aactacatta    35100

atgaaatatt tgccacatcc tcttacactt tttcatacat tgcccaagaa taaagaatcg    35160

tttgtgttat gtttcaacgt gtttattttt caattgcaga aaatttcaag tcatttttca    35220

ttcagtagta tagccccacc accacatagc ttatacagat caccgtacct taatcaaact    35280

cacagaaccc tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt    35340

tctccccggc tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt    35400

atattccaca cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg    35460

ggcagctcac ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact    35520

tgcggttgct taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa    35580

tcgtgcatca ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc    35640

cgctccgtcc tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc    35700

cgcagcataa ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca    35760

gcacagtaac tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg    35820

tatccaaagc tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg    35880

tagattaagt ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg    35940

ttgtaattca ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc    36000

accatcctaa accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga    36060

ctggaacaat gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg    36120

atatcaatgt tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc    36180

tcccgcgtta gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca    36240

ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc    36300

agcagcggat gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga    36360

tccctactgt acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca    36420

aatggaacgc cggacgtagt catatttcca gtaaaaaaga aaacctatta aaaaaacacc    36480

actcgacacg gcaccagctc aatcagtcac agtgtaaaaa agggccaagt gcagagcgag    36540

tatatatagg actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac ccagaaaacc    36600

gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc acaacttcct caaatcgtca    36660

cttccgtttt cccacgttac gtaacttccc attttaagaa aactacaatt cccaacacat    36720

acaagttact ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt    36780

cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga    36840

tgatg                                                                36845


<210>  23
<211>  35938
<212>  DNA
<213>  Adenovrius type 5

<400>  23
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag      240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga      300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg      360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc      420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg      480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc      540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga      600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc      660

tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc      720

cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt      780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca      840

cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa      900

ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga      960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg     1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg     1080

ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga     1140

tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa     1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag     1260

ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga     1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt     1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt     1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag     1500

cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga     1560

ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt     1620

gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg     1680

cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat     1740

ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg     1800

tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg     1860

gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac     1920

caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct     1980

gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg     2040

agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac     2100

aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag     2160

cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga     2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga     2280

gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg     2340

gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc     2400

gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc     2460

tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt     2520

ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga     2580

tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg     2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg     2700

tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg     2760

gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta     2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct     2880

gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg     2940

aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct     3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat     3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc     3120

tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata     3180

acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc     3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc     3300

tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc     3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc     3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt     3480

ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg     3540

tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg     3600

ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc     3660

gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc     3720

ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg     3780

agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg     3840

actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg     3900

acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt     3960

ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca     4020

atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcaagtgt     4080

cttgctgtct ttatttaggg gttttgcgcg cgcggtaggc ccgggaccag cggtctcggt     4140

cgttgagggt cctgtgtatt ttttccagga cgtggtaaag gtgactctgg atgttcagat     4200

acatgggcat aagcccgtct ctggggtgga ggtagcacca ctgcagagct tcatgctgcg     4260

gggtggtgtt gtagatgatc cagtcgtagc aggagcgctg ggcgtggtgc ctaaaaatgt     4320

ctttcagtag caagctgatt gccaggggca ggcccttggt gtaagtgttt acaaagcggt     4380

taagctggga tgggtgcata cgtggggata tgagatgcat cttggactgt atttttaggt     4440

tggctatgtt cccagccata tccctccggg gattcatgtt gtgcagaacc accagcacag     4500

tgtatccggt gcacttggga aatttgtcat gtagcttaga aggaaatgcg tggaagaact     4560

tggagacgcc cttgtgacct ccaagatttt ccatgcattc gtccataatg atggcaatgg     4620

gcccacgggc ggcggcctgg gcgaagatat ttctgggatc actaacgtca tagttgtgtt     4680

ccaggatgag atcgtcatag gccattttta caaagcgcgg gcggagggtg ccagactgcg     4740

gtataatggt tccatccggc ccaggggcgt agttaccctc acagatttgc atttcccacg     4800

ctttgagttc agatgggggg atcatgtcta cctgcggggc gatgaagaaa acggtttccg     4860

gggtagggga gatcagctgg gaagaaagca ggttcctgag cagctgcgac ttaccgcagc     4920

cggtgggccc gtaaatcaca cctattaccg ggtgcaactg gtagttaaga gagctgcagc     4980

tgccgtcatc cctgagcagg ggggccactt cgttaagcat gtccctgact cgcatgtttt     5040

ccctgaccaa atccgccaga aggcgctcgc cgcccagcga tagcagttct tgcaaggaag     5100

caaagttttt caacggtttg agaccgtccg ccgtaggcat gcttttgagc gtttgaccaa     5160

gcagttccag gcggtcccac agctcggtca cctgctctac ggcatctcga tccagcatat     5220

ctcctcgttt cgcgggttgg ggcggctttc gctgtacggc agtagtcggt gctcgtccag     5280

acgggccagg gtcatgtctt tccacgggcg cagggtcctc gtcagcgtag tctgggtcac     5340

ggtgaagggg tgcgctccgg gctgcgcgct ggccagggtg cgcttgaggc tggtcctgct     5400

ggtgctgaag cgctgccggt cttcgccctg cgcgtcggcc aggtagcatt tgaccatggt     5460

gtcatagtcc agcccctccg cggcgtggcc cttggcgcgc agcttgccct tggaggaggc     5520

gccgcacgag gggcagtgca gacttttgag ggcgtagagc ttgggcgcga gaaataccga     5580

ttccggggag taggcatccg cgccgcaggc cccgcagacg gtctcgcatt ccacgagcca     5640

ggtgagctct ggccgttcgg ggtcaaaaac caggtttccc ccatgctttt tgatgcgttt     5700

cttacctctg gtttccatga gccggtgtcc acgctcggtg acgaaaaggc tgtccgtgtc     5760

cccgtataca gacttgagag gcctgtcctc gagcggtgtt ccgcggtcct cctcgtatag     5820

aaactcggac cactctgaga caaaggctcg cgtccaggcc agcacgaagg aggctaagtg     5880

ggaggggtag cggtcgttgt ccactagggg gtccactcgc tccagggtgt gaagacacat     5940

gtcgccctct tcggcatcaa ggaaggtgat tggtttgtag gtgtaggcca cgtgaccggg     6000

tgttcctgaa ggggggctat aaaagggggt gggggcgcgt tcgtcctcac tctcttccgc     6060

atcgctgtct gcgagggcca gctgttgggg tgagtactcc ctctgaaaag cgggcatgac     6120

ttctgcgcta agattgtcag tttccaaaaa cgaggaggat ttgatattca cctggcccgc     6180

ggtgatgcct ttgagggtgg ccgcatccat ctggtcagaa aagacaatct ttttgttgtc     6240

aagcttggtg gcaaacgacc cgtagagggc gttggacagc aacttggcga tggagcgcag     6300

ggtttggttt ttgtcgcgat cggcgcgctc cttggccgcg atgtttagct gcacgtattc     6360

gcgcgcaacg caccgccatt cgggaaagac ggtggtgcgc tcgtcgggca ccaggtgcac     6420

gcgccaaccg cggttgtgca gggtgacaag gtcaacgctg gtggctacct ctccgcgtag     6480

gcgctcgttg gtccagcaga ggcggccgcc cttgcgcgag cagaatggcg gtagggggtc     6540

tagctgcgtc tcgtccgggg ggtctgcgtc cacggtaaag accccgggca gcaggcgcgc     6600

gtcgaagtag tctatcttgc atccttgcaa gtctagcgcc tgctgccatg cgcgggcggc     6660

aagcgcgcgc tcgtatgggt tgagtggggg accccatggc atggggtggg tgagcgcgga     6720

ggcgtacatg ccgcaaatgt cgtaaacgta gaggggctct ctgagtattc caagatatgt     6780

agggtagcat cttccaccgc ggatgctggc gcgcacgtaa tcgtatagtt cgtgcgaggg     6840

agcgaggagg tcgggaccga ggttgctacg ggcgggctgc tctgctcgga agactatctg     6900

cctgaagatg gcatgtgagt tggatgatat ggttggacgc tggaagacgt tgaagctggc     6960

gtctgtgaga cctaccgcgt cacgcacgaa ggaggcgtag gagtcgcgca gcttgttgac     7020

cagctcggcg gtgacctgca cgtctagggc gcagtagtcc agggtttcct tgatgatgtc     7080

atacttatcc tgtccctttt ttttccacag ctcgcggttg aggacaaact cttcgcggtc     7140

tttccagtac tcttggatcg gaaacccgtc ggcctccgaa cggtaagagc ctagcatgta     7200

gaactggttg acggcctggt aggcgcagca tcccttttct acgggtagcg cgtatgcctg     7260

cgcggccttc cggagcgagg tgtgggtgag cgcaaaggtg tccctgacca tgactttgag     7320

gtactggtat ttgaagtcag tgtcgtcgca tccgccctgc tcccagagca aaaagtccgt     7380

gcgctttttg gaacgcggat ttggcagggc gaaggtgaca tcgttgaaga gtatctttcc     7440

cgcgcgaggc ataaagttgc gtgtgatgcg gaagggtccc ggcacctcgg aacggttgtt     7500

aattacctgg gcggcgagca cgatctcgtc aaagccgttg atgttgtggc ccacaatgta     7560

aagttccaag aagcgcggga tgcccttgat ggaaggcaat tttttaagtt cctcgtaggt     7620

gagctcttca ggggagctga gcccgtgctc tgaaagggcc cagtctgcaa gatgagggtt     7680

ggaagcgacg aatgagctcc acaggtcacg ggccattagc atttgcaggt ggtcgcgaaa     7740

ggtcctaaac tggcgaccta tggccatttt ttctggggtg atgcagtaga aggtaagcgg     7800

gtcttgttcc cagcggtccc atccaaggtt cgcggctagg tctcgcgcgg cagtcactag     7860

aggctcatct ccgccgaact tcatgaccag catgaagggc acgagctgct tcccaaaggc     7920

ccccatccaa gtataggtct ctacatcgta ggtgacaaag agacgctcgg tgcgaggatg     7980

cgagccgatc gggaagaact ggatctcccg ccaccaattg gaggagtggc tattgatgtg     8040

gtgaaagtag aagtccctgc gacgggccga acactcgtgc tggcttttgt aaaaacgtgc     8100

gcagtactgg cagcggtgca cgggctgtac atcctgcacg aggttgacct gacgaccgcg     8160

cacaaggaag cagagtggga atttgagccc ctcgcctggc gggtttggct ggtggtcttc     8220

tacttcggct gcttgtcctt gaccgtctgg ctgctcgagg ggagttacgg tggatcggac     8280

caccacgccg cgcgagccca aagtccagat gtccgcgcgc ggcggtcgga gcttgatgac     8340

aacatcgcgc agatgggagc tgtccatggt ctggagctcc cgcggcgtca ggtcaggcgg     8400

gagctcctgc aggtttacct cgcatagacg ggtcagggcg cgggctagat ccaggtgata     8460

cctaatttcc aggggctggt tggtggcggc gtcgatggct tgcaagaggc cgcatccccg     8520

cggcgcgact acggtaccgc gcggcgggcg gtgggccgcg ggggtgtcct tggatgatgc     8580

atctaaaagc ggtgacgcgg gcgagccccc ggaggtaggg ggggctccgg acccgccggg     8640

agagggggca ggggcacgtc ggcgccgcgc gcgggcagga gctggtgctg cgcgcgtagg     8700

ttgctggcga acgcgacgac gcggcggttg atctcctgaa tctggcgcct ctgcgtgaag     8760

acgacgggcc cggtgagctt gagcctgaaa gagagttcga cagaatcaat ttcggtgtcg     8820

ttgacggcgg cctggcgcaa aatctcctgc acgtctcctg agttgtcttg ataggcgatc     8880

tcggccatga actgctcgat ctcttcctcc tggagatctc cgcgtccggc tcgctccacg     8940

gtggcggcga ggtcgttgga aatgcgggcc atgagctgcg agaaggcgtt gaggcctccc     9000

tcgttccaga cgcggctgta gaccacgccc ccttcggcat cgcgggcgcg catgaccacc     9060

tgcgcgagat tgagctccac gtgccgggcg aagacggcgt agtttcgcag gcgctgaaag     9120

aggtagttga gggtggtggc ggtgtgttct gccacgaaga agtacataac ccagcgtcgc     9180

aacgtggatt cgttgatatc ccccaaggcc tcaaggcgct ccatggcctc gtagaagtcc     9240

acggcgaagt tgaaaaactg ggagttgcgc gccgacacgg ttaactcctc ctccagaaga     9300

cggatgagct cggcgacagt gtcgcgcacc tcgcgctcaa aggctacagg ggcctcttct     9360

tcttcttcaa tctcctcttc cataagggcc tccccttctt cttcttctgg cggcggtggg     9420

ggagggggga cacggcggcg acgacggcgc accgggaggc ggtcgacaaa gcgctcgatc     9480

atctccccgc ggcgacggcg catggtctcg gtgacggcgc ggccgttctc gcgggggcgc     9540

agttggaaga cgccgcccgt catgtcccgg ttatgggttg gcggggggct gccatgcggc     9600

agggatacgg cgctaacgat gcatctcaac aattgttgtg taggtactcc gccgccgagg     9660

gacctgagcg agtccgcatc gaccggatcg gaaaacctct cgagaaaggc gtctaaccag     9720

tcacagtcgc aaggtaggct gagcaccgtg gcgggcggca gcgggcggcg gtcggggttg     9780

tttctggcgg aggtgctgct gatgatgtaa ttaaagtagg cggtcttgag acggcggatg     9840

gtcgacagaa gcaccatgtc cttgggtccg gcctgctgaa tgcgcaggcg gtcggccatg     9900

ccccaggctt cgttttgaca tcggcgcagg tctttgtagt agtcttgcat gagcctttct     9960

accggcactt cttcttctcc ttcctcttgt cctgcatctc ttgcatctat cgctgcggcg    10020

gcggcggagt ttggccgtag gtggcgccct cttcctccca tgcgtgtgac cccgaagccc    10080

ctcatcggct gaagcagggc taggtcggcg acaacgcgct cggctaatat ggcctgctgc    10140

acctgcgtga gggtagactg gaagtcatcc atgtccacaa agcggtggta tgcgcccgtg    10200

ttgatggtgt aagtgcagtt ggccataacg gaccagttaa cggtctggtg acccggctgc    10260

gagagctcgg tgtacctgag acgcgagtaa gccctcgagt caaatacgta gtcgttgcaa    10320

gtccgcacca ggtactggta tcccaccaaa aagtgcggcg gcggctggcg gtagaggggc    10380

cagcgtaggg tggccggggc tccgggggcg agatcttcca acataaggcg atgatatccg    10440

tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg cggaaagtcg    10500

cggacgcggt tccagatgtt gcgcagcggc aaaaagtgct ccatggtcgg gacgctctgg    10560

ccggtcaggc gcgcgcaatc gttgacgctc tagaccgtgc aaaaggagag cctgtaagcg    10620

ggcactcttc cgtggtctgg tggataaatt cgcaagggta tcatggcgga cgaccggggt    10680

tcgagccccg tatccggccg tccgccgtga tccatgcggt taccgcccgc gtgtcgaacc    10740

caggtgtgcg acgtcagaca acgggggagt gctccttttg gcttccttcc aggcgcggcg    10800

gctgctgcgc tagctttttt ggccactggc cgcgcgcagc gtaagcggtt aggctggaaa    10860

gcgaaagcat taagtggctc gctccctgta gccggagggt tattttccaa gggttgagtc    10920

gcgggacccc cggttcgagt ctcggaccgg ccggactgcg gcgaacgggg gtttgcctcc    10980

ccgtcatgca agaccccgct tgcaaattcc tccggaaaca gggacgagcc ccttttttgc    11040

ttttcccaga tgcatccggt gctgcggcag atgcgccccc ctcctcagca gcggcaagag    11100

caagagcagc ggcagacatg cagggcaccc tcccctcctc ctaccgcgtc aggaggggcg    11160

acatccgcgg ttgacgcggc agcagatggt gattacgaac ccccgcggcg ccgggcccgg    11220

cactacctgg acttggagga gggcgagggc ctggcgcggc taggagcgcc ctctcctgag    11280

cggtacccaa gggtgcagct gaagcgtgat acgcgtgagg cgtacgtgcc gcggcagaac    11340

ctgtttcgcg accgcgaggg agaggagccc gaggagatgc gggatcgaaa gttccacgca    11400

gggcgcgagc tgcggcatgg cctgaatcgc gagcggttgc tgcgcgagga ggactttgag    11460

cccgacgcgc gaaccgggat tagtcccgcg cgcgcacacg tggcggccgc cgacctggta    11520

accgcatacg agcagacggt gaaccaggag attaactttc aaaaaagctt taacaaccac    11580

gtgcgtacgc ttgtggcgcg cgaggaggtg gctataggac tgatgcatct gtgggacttt    11640

gtaagcgcgc tggagcaaaa cccaaatagc aagccgctca tggcgcagct gttccttata    11700

gtgcagcaca gcagggacaa cgaggcattc agggatgcgc tgctaaacat agtagagccc    11760

gagggccgct ggctgctcga tttgataaac atcctgcaga gcatagtggt gcaggagcgc    11820

agcttgagcc tggctgacaa ggtggccgcc atcaactatt ccatgcttag cctgggcaag    11880

ttttacgccc gcaagatata ccatacccct tacgttccca tagacaagga ggtaaagatc    11940

gaggggttct acatgcgcat ggcgctgaag gtgcttacct tgagcgacga cctgggcgtt    12000

tatcgcaacg agcgcatcca caaggccgtg agcgtgagcc ggcggcgcga gctcagcgac    12060

cgcgagctga tgcacagcct gcaaagggcc ctggctggca cgggcagcgg cgatagagag    12120

gccgagtcct actttgacgc gggcgctgac ctgcgctggg ccccaagccg acgcgccctg    12180

gaggcagctg gggccggacc tgggctggcg gtggcacccg cgcgcgctgg caacgtcggc    12240

ggcgtggagg aatatgacga ggacgatgag tacgagccag aggacggcga gtactaagcg    12300

gtgatgtttc tgatcagatg atgcaagacg caacggaccc ggcggtgcgg gcggcgctgc    12360

agagccagcc gtccggcctt aactccacgg acgactggcg ccaggtcatg gaccgcatca    12420

tgtcgctgac tgcgcgcaat cctgacgcgt tccggcagca gccgcaggcc aaccggctct    12480

ccgcaattct ggaagcggtg gtcccggcgc gcgcaaaccc cacgcacgag aaggtgctgg    12540

cgatcgtaaa cgcgctggcc gaaaacaggg ccatccggcc cgacgaggcc ggcctggtct    12600

acgacgcgct gcttcagcgc gtggctcgtt acaacagcgg caacgtgcag accaacctgg    12660

accggctggt gggggatgtg cgcgaggccg tggcgcagcg tgagcgcgcg cagcagcagg    12720

gcaacctggg ctccatggtt gcactaaacg ccttcctgag tacacagccc gccaacgtgc    12780

cgcggggaca ggaggactac accaactttg tgagcgcact gcggctaatg gtgactgaga    12840

caccgcaaag tgaggtgtac cagtctgggc cagactattt tttccagacc agtagacaag    12900

gcctgcagac cgtaaacctg agccaggctt tcaaaaactt gcaggggctg tggggggtgc    12960

gggctcccac aggcgaccgc gcgaccgtgt ctagcttgct gacgcccaac tcgcgcctgt    13020

tgctgctgct aatagcgccc ttcacggaca gtggcagcgt gtcccgggac acatacctag    13080

gtcacttgct gacactgtac cgcgaggcca taggtcaggc gcatgtggac gagcatactt    13140

tccaggagat tacaagtgtc agccgcgcgc tggggcagga ggacacgggc agcctggagg    13200

caaccctaaa ctacctgctg accaaccggc ggcagaagat cccctcgttg cacagtttaa    13260

acagcgagga ggagcgcatt ttgcgctacg tgcagcagag cgtgagcctt aacctgatgc    13320

gcgacggggt aacgcccagc gtggcgctgg acatgaccgc gcgcaacatg gaaccgggca    13380

tgtatgcctc aaaccggccg tttatcaacc gcctaatgga ctacttgcat cgcgcggccg    13440

ccgtgaaccc cgagtatttc accaatgcca tcttgaaccc gcactggcta ccgccccctg    13500

gtttctacac cgggggattc gaggtgcccg agggtaacga tggattcctc tgggacgaca    13560

tagacgacag cgtgttttcc ccgcaaccgc agaccctgct agagttgcaa cagcgcgagc    13620

aggcagaggc ggcgctgcga aaggaaagct tccgcaggcc aagcagcttg tccgatctag    13680

gcgctgcggc cccgcggtca gatgctagta gcccatttcc aagcttgata gggtctctta    13740

ccagcactcg caccacccgc ccgcgcctgc tgggcgagga ggagtaccta aacaactcgc    13800

tgctgcagcc gcagcgcgaa aaaaacctgc ctccggcatt tcccaacaac gggatagaga    13860

gcctagtgga caagatgagt agatggaaga cgtacgcgca ggagcacagg gacgtgccag    13920

gcccgcgccc gcccacccgt cgtcaaaggc acgaccgtca gcggggtctg gtgtgggagg    13980

acgatgactc ggcagacgac agcagcgtcc tggatttggg agggagtggc aacccgtttg    14040

cgcaccttcg ccccaggctg gggagaatgt tttaaaaaaa aaaaagcatg atgcaaaata    14100

aaaaactcac caaggccatg gcaccgagcg ttggttttct tgtattcccc ttagtatgcg    14160

gcgcgcggcg atgtatgagg aaggtcctcc tccctcctac gagagtgtgg tgagcgcggc    14220

gccagtggcg gcggcgctgg gttctccctt cgatgctccc ctggacccgc cgtttgtgcc    14280

tccgcggtac ctgcggccta ccggggggag aaacagcatc cgttactctg agttggcacc    14340

cctattcgac accacccgtg tgtacctggt ggacaacaag tcaacggatg tggcatccct    14400

gaactaccag aacgaccaca gcaactttct gaccacggtc attcaaaaca atgactacag    14460

cccgggggag gcaagcacac agaccatcaa tcttgacgac cggtcgcact ggggcggcga    14520

cctgaaaacc atcctgcata ccaacatgcc aaatgtgaac gagttcatgt ttaccaataa    14580

gtttaaggcg cgggtgatgg tgtcgcgctt gcctactaag gacaatcagg tggagctgaa    14640

atacgagtgg gtggagttca cgctgcccga gggcaactac tccgagacca tgaccataga    14700

ccttatgaac aacgcgatcg tggagcacta cttgaaagtg ggcagacaga acggggttct    14760

ggaaagcgac atcggggtaa agtttgacac ccgcaacttc agactggggt ttgaccccgt    14820

cactggtctt gtcatgcctg gggtatatac aaacgaagcc ttccatccag acatcatttt    14880

gctgccagga tgcggggtgg acttcaccca cagccgcctg agcaacttgt tgggcatccg    14940

caagcggcaa cccttccagg agggctttag gatcacctac gatgatctgg agggtggtaa    15000

cattcccgca ctgttggatg tggacgccta ccaggcgagc ttgaaagatg acaccgaaca    15060

gggcgggggt ggcgcaggcg gcagcaacag cagtggcagc ggcgcggaag agaactccaa    15120

cgcggcagcc gcggcaatgc agccggtgga ggacatgaac gatcatgcca ttcgcggcga    15180

cacctttgcc acacgggctg aggagaagcg cgctgaggcc gaagcagcgg ccgaagctgc    15240

cgcccccgct gcgcaacccg aggtcgagaa gcctcagaag aaaccggtga tcaaacccct    15300

gacagaggac agcaagaaac gcagttacaa cctaataagc aatgacagca ccttcaccca    15360

gtaccgcagc tggtaccttg catacaacta cggcgaccct cagaccggaa tccgctcatg    15420

gaccctgctt tgcactcctg acgtaacctg cggctcggag caggtctact ggtcgttgcc    15480

agacatgatg caagaccccg tgaccttccg ctccacgcgc cagatcagca actttccggt    15540

ggtgggcgcc gagctgttgc ccgtgcactc caagagcttc tacaacgacc aggccgtcta    15600

ctcccaactc atccgccagt ttacctctct gacccacgtg ttcaatcgct ttcccgagaa    15660

ccagattttg gcgcgcccgc cagcccccac catcaccacc gtcagtgaaa acgttcctgc    15720

tctcacagat cacgggacgc taccgctgcg caacagcatc ggaggagtcc agcgagtgac    15780

cattactgac gccagacgcc gcacctgccc ctacgtttac aaggccctgg gcatagtctc    15840

gccgcgcgtc ctatcgagcc gcactttttg agcaagcatg tccatcctta tatcgcccag    15900

caataacaca ggctggggcc tgcgcttccc aagcaagatg tttggcgggg ccaagaagcg    15960

ctccgaccaa cacccagtgc gcgtgcgcgg gcactaccgc gcgccctggg gcgcgcacaa    16020

acgcggccgc actgggcgca ccaccgtcga tgacgccatc gacgcggtgg tggaggaggc    16080

gcgcaactac acgcccacgc cgccaccagt gtccacagtg gacgcggcca ttcagaccgt    16140

ggtgcgcgga gcccggcgct atgctaaaat gaagagacgg cggaggcgcg tagcacgtcg    16200

ccaccgccgc cgacccggca ctgccgccca acgcgcggcg gcggccctgc ttaaccgcgc    16260

acgtcgcacc ggccgacggg cggccatgcg ggccgctcga aggctggccg cgggtattgt    16320

cactgtgccc cccaggtcca ggcgacgagc ggccgccgca gcagccgcgg ccattagtgc    16380

tatgactcag ggtcgcaggg gcaacgtgta ttgggtgcgc gactcggtta gcggcctgcg    16440

cgtgcccgtg cgcacccgcc ccccgcgcaa ctagattgca agaaaaaact acttagactc    16500

gtactgttgt atgtatccag cggcggcggc gcgcaacgaa gctatgtcca agcgcaaaat    16560

caaagaagag atgctccagg tcatcgcgcc ggagatctat ggccccccga agaaggaaga    16620

gcaggattac aagccccgaa agctaaagcg ggtcaaaaag aaaaagaaag atgatgatga    16680

tgaacttgac gacgaggtgg aactgctgca cgctaccgcg cccaggcgac gggtacagtg    16740

gaaaggtcga cgcgtaaaac gtgttttgcg acccggcacc accgtagtct ttacgcccgg    16800

tgagcgctcc acccgcacct acaagcgcgt gtatgatgag gtgtacggcg acgaggacct    16860

gcttgagcag gccaacgagc gcctcgggga gtttgcctac ggaaagcggc ataaggacat    16920

gctggcgttg ccgctggacg agggcaaccc aacacctagc ctaaagcccg taacactgca    16980

gcaggtgctg cccgcgcttg caccgtccga agaaaagcgc ggcctaaagc gcgagtctgg    17040

tgacttggca cccaccgtgc agctgatggt acccaagcgc cagcgactgg aagatgtctt    17100

ggaaaaaatg accgtggaac ctgggctgga gcccgaggtc cgcgtgcggc caatcaagca    17160

ggtggcgccg ggactgggcg tgcagaccgt ggacgttcag atacccacta ccagtagcac    17220

cagtattgcc accgccacag agggcatgga gacacaaacg tccccggttg cctcagcggt    17280

ggcggatgcc gcggtgcagg cggtcgctgc ggccgcgtcc aagacctcta cggaggtgca    17340

aacggacccg tggatgtttc gcgtttcagc cccccggcgc ccgcgcggtt cgaggaagta    17400

cggcgccgcc agcgcgctac tgcccgaata tgccctacat ccttccattg cgcctacccc    17460

cggctatcgt ggctacacct accgccccag aagacgagca actacccgac gccgaaccac    17520

cactggaacc cgccgccgcc gtcgccgtcg ccagcccgtg ctggccccga tttccgtgcg    17580

cagggtggct cgcgaaggag gcaggaccct ggtgctgcca acagcgcgct accaccccag    17640

catcgtttaa aagccggtct ttgtggttct tgcagatatg gccctcacct gccgcctccg    17700

tttcccggtg ccgggattcc gaggaagaat gcaccgtagg aggggcatgg ccggccacgg    17760

cctgacgggc ggcatgcgtc gtgcgcacca ccggcggcgg cgcgcgtcgc accgtcgcat    17820

gcgcggcggt atcctgcccc tccttattcc actgatcgcc gcggcgattg gcgccgtgcc    17880

cggaattgca tccgtggcct tgcaggcgca gagacactga ttaaaaacaa gttgcatgtg    17940

gaaaaatcaa aataaaaagt ctggactctc acgctcgctt ggtcctgtaa ctattttgta    18000

gaatggaaga catcaacttt gcgtctctgg ccccgcgaca cggctcgcgc ccgttcatgg    18060

gaaactggca agatatcggc accagcaata tgagcggtgg cgccttcagc tggggctcgc    18120

tgtggagcgg cattaaaaat ttcggttcca ccgttaagaa ctatggcagc aaggcctgga    18180

acagcagcac aggccagatg ctgagggata agttgaaaga gcaaaatttc caacaaaagg    18240

tggtagatgg cctggcctct ggcattagcg gggtggtgga cctggccaac caggcagtgc    18300

aaaataagat taacagtaag cttgatcccc gccctcccgt agaggagcct ccaccggccg    18360

tggagacagt gtctccagag gggcgtggcg aaaagcgtcc gcgccccgac agggaagaaa    18420

ctctggtgac gcaaatagac gagcctccct cgtacgagga ggcactaaag caaggcctgc    18480

ccaccacccg tcccatcgcg cccatggcta ccggagtgct gggccagcac acacccgtaa    18540

cgctggacct gcctcccccc gccgacaccc agcagaaacc tgtgctgcca ggcccgaccg    18600

ccgttgttgt aacccgtcct agccgcgcgt ccctgcgccg cgccgccagc ggtccgcgat    18660

cgttgcggcc cgtagccagt ggcaactggc aaagcacact gaacagcatc gtgggtctgg    18720

gggtgcaatc cctgaagcgc cgacgatgct tctgaatagc taacgtgtcg tatgtgtgtc    18780

atgtatgcgt ccatgtcgcc gccagaggag ctgctgagcc gccgcgcgcc cgctttccaa    18840

gatggctacc ccttcgatga tgccgcagtg gtcttacatg cacatctcgg gccaggacgc    18900

ctcggagtac ctgagccccg ggctggtgca gtttgcccgc gccaccgaga cgtacttcag    18960

cctgaataac aagtttagaa accccacggt ggcgcctacg cacgacgtga ccacagaccg    19020

gtcccagcgt ttgacgctgc ggttcatccc tgtggaccgt gaggatactg cgtactcgta    19080

caaggcgcgg ttcaccctag ctgtgggtga taaccgtgtg ctggacatgg cttccacgta    19140

ctttgacatc cgcggcgtgc tggacagggg ccctactttt aagccctact ctggcactgc    19200

ctacaacgcc ctggctccca agggtgcccc aaatccttgc gaatgggatg aagctgctac    19260

tgctcttgaa ataaacctag aagaagagga cgatgacaac gaagacgaag tagacgagca    19320

agctgagcag caaaaaactc acgtatttgg gcaggcgcct tattctggta taaatattac    19380

aaaggagggt attcaaatag gtgtcgaagg tcaaacacct aaatatgccg ataaaacatt    19440

tcaacctgaa cctcaaatag gagaatctca gtggtacgaa actgaaatta atcatgcagc    19500

tgggagagtc cttaaaaaga ctaccccaat gaaaccatgt tacggttcat atgcaaaacc    19560

cacaaatgaa aatggagggc aaggcattct tgtaaagcaa caaaatggaa agctagaaag    19620

tcaagtggaa atgcaatttt tctcaactac tgaggcgacc gcaggcaatg gtgataactt    19680

gactcctaaa gtggtattgt acagtgaaga tgtagatata gaaaccccag acactcatat    19740

ttcttacatg cccactatta aggaaggtaa ctcacgagaa ctaatgggcc aacaatctat    19800

gcccaacagg cctaattaca ttgcttttag ggacaatttt attggtctaa tgtattacaa    19860

cagcacgggt aatatgggtg ttctggcggg ccaagcatcg cagttgaatg ctgttgtaga    19920

tttgcaagac agaaacacag agctttcata ccagcttttg cttgattcca ttggtgatag    19980

aaccaggtac ttttctatgt ggaatcaggc tgttgacagc tatgatccag atgttagaat    20040

tattgaaaat catggaactg aagatgaact tccaaattac tgctttccac tgggaggtgt    20100

gattaataca gagactctta ccaaggtaaa acctaaaaca ggtcaggaaa atggatggga    20160

aaaagatgct acagaatttt cagataaaaa tgaaataaga gttggaaata attttgccat    20220

ggaaatcaat ctaaatgcca acctgtggag aaatttcctg tactccaaca tagcgctgta    20280

tttgcccgac aagctaaagt acagtccttc caacgtaaaa atttctgata acccaaacac    20340

ctacgactac atgaacaagc gagtggtggc tcccgggtta gtggactgct acattaacct    20400

tggagcacgc tggtcccttg actatatgga caacgtcaac ccatttaacc accaccgcaa    20460

tgctggcctg cgctaccgct caatgttgct gggcaatggt cgctatgtgc ccttccacat    20520

ccaggtgcct cagaagttct ttgccattaa aaacctcctt ctcctgccgg gctcatacac    20580

ctacgagtgg aacttcagga aggatgttaa catggttctg cagagctccc taggaaatga    20640

cctaagggtt gacggagcca gcattaagtt tgatagcatt tgcctttacg ccaccttctt    20700

ccccatggcc cacaacaccg cctccacgct tgaggccatg cttagaaacg acaccaacga    20760

ccagtccttt aacgactatc tctccgccgc caacatgctc taccctatac ccgccaacgc    20820

taccaacgtg cccatatcca tcccctcccg caactgggcg gctttccgcg gctgggcctt    20880

cacgcgcctt aagactaagg aaaccccatc actgggctcg ggctacgacc cttattacac    20940

ctactctggc tctataccct acctagatgg aaccttttac ctcaaccaca cctttaagaa    21000

ggtggccatt acctttgact cttctgtcag ctggcctggc aatgaccgcc tgcttacccc    21060

caacgagttt gaaattaagc gctcagttga cggggagggt tacaacgttg cccagtgtaa    21120

catgaccaaa gactggttcc tggtacaaat gctagctaac tacaacattg gctaccaggg    21180

cttctatatc ccagagagct acaaggaccg catgtactcc ttctttagaa acttccagcc    21240

catgagccgt caggtggtgg atgatactaa atacaaggac taccaacagg tgggcatcct    21300

acaccaacac aacaactctg gatttgttgg ctaccttgcc cccaccatgc gcgaaggaca    21360

ggcctaccct gctaacttcc cctatccgct tataggcaag accgcagttg acagcattac    21420

ccagaaaaag tttctttgcg atcgcaccct ttggcgcatc ccattctcca gtaactttat    21480

gtccatgggc gcactcacag acctgggcca aaaccttctc tacgccaact ccgcccacgc    21540

gctagacatg acttttgagg tggatcccat ggacgagccc acccttcttt atgttttgtt    21600

tgaagtcttt gacgtggtcc gtgtgcaccg gccgcaccgc ggcgtcatcg aaaccgtgta    21660

cctgcgcacg cccttctcgg ccggcaacgc cacaacataa agaagcaagc aacatcaaca    21720

acagctgccg ccatgggctc cagtgagcag gaactgaaag ccattgtcaa agatcttggt    21780

tgtgggccat attttttggg cacctatgac aagcgctttc caggctttgt ttctccacac    21840

aagctcgcct gcgccatagt caatacggcc ggtcgcgaga ctgggggcgt acactggatg    21900

gcctttgcct ggaacccgca ctcaaaaaca tgctacctct ttgagccctt tggcttttct    21960

gaccagcgac tcaagcaggt ttaccagttt gagtacgagt cactcctgcg ccgtagcgcc    22020

attgcttctt cccccgaccg ctgtataacg ctggaaaagt ccacccaaag cgtacagggg    22080

cccaactcgg ccgcctgtgg actattctgc tgcatgtttc tccacgcctt tgccaactgg    22140

ccccaaactc ccatggatca caaccccacc atgaacctta ttaccggggt acccaactcc    22200

atgctcaaca gtccccaggt acagcccacc ctgcgtcgca accaggaaca gctctacagc    22260

ttcctggagc gccactcgcc ctacttccgc agccacagtg cgcagattag gagcgccact    22320

tctttttgtc acttgaaaaa catgtaaaaa taatgtacta gagacacttt caataaaggc    22380

aaatgctttt atttgtacac tctcgggtga ttatttaccc ccacccttgc cgtctgcgcc    22440

gtttaaaaat caaaggggtt ctgccgcgca tcgctatgcg ccactggcag ggacacgttg    22500

cgatactggt gtttagtgct ccacttaaac tcaggcacaa ccatccgcgg cagctcggtg    22560

aagttttcac tccacaggct gcgcaccatc accaacgcgt ttagcaggtc gggcgccgat    22620

atcttgaagt cgcagttggg gcctccgccc tgcgcgcgcg agttgcgata cacagggttg    22680

cagcactgga acactatcag cgccgggtgg tgcacgctgg ccagcacgct cttgtcggag    22740

atcagatccg cgtccaggtc ctccgcgttg ctcagggcga acggagtcaa ctttggtagc    22800

tgccttccca aaaagggcgc gtgcccaggc tttgagttgc actcgcaccg tagtggcatc    22860

aaaaggtgac cgtgcccggt ctgggcgtta ggatacagcg cctgcataaa agccttgatc    22920

tgcttaaaag ccacctgagc ctttgcgcct tcagagaaga acatgccgca agacttgccg    22980

gaaaactgat tggccggaca ggccgcgtcg tgcacgcagc accttgcgtc ggtgttggag    23040

atctgcacca catttcggcc ccaccggttc ttcacgatct tggccttgct agactgctcc    23100

ttcagcgcgc gctgcccgtt ttcgctcgtc acatccattt caatcacgtg ctccttattt    23160

atcataatgc ttccgtgtag acacttaagc tcgccttcga tctcagcgca gcggtgcagc    23220

cacaacgcgc agcccgtggg ctcgtgatgc ttgtaggtca cctctgcaaa cgactgcagg    23280

tacgcctgca ggaatcgccc catcatcgtc acaaaggtct tgttgctggt gaaggtcagc    23340

tgcaacccgc ggtgctcctc gttcagccag gtcttgcata cggccgccag agcttccact    23400

tggtcaggca gtagtttgaa gttcgccttt agatcgttat ccacgtggta cttgtccatc    23460

agcgcgcgcg cagcctccat gcccttctcc cacgcagaca cgatcggcac actcagcggg    23520

ttcatcaccg taatttcact ttccgcttcg ctgggctctt cctcttcctc ttgcgtccgc    23580

ataccacgcg ccactgggtc gtcttcattc agccgccgca ctgtgcgctt acctcctttg    23640

ccatgcttga ttagcaccgg tgggttgctg aaacccacca tttgtagcgc cacatcttct    23700

ctttcttcct cgctgtccac gattacctct ggtgatggcg ggcgctcggg cttgggagaa    23760

gggcgcttct ttttcttctt gggcgcaatg gccaaatccg ccgccgaggt cgatggccgc    23820

gggctgggtg tgcgcggcac cagcgcgtct tgtgatgagt cttcctcgtc ctcggactcg    23880

atacgccgcc tcatccgctt ttttgggggc gcccggggag gcggcggcga cggggacggg    23940

gacgacacgt cctccatggt tgggggacgt cgcgccgcac cgcgtccgcg ctcgggggtg    24000

gtttcgcgct gctcctcttc ccgactggcc atttccttct cctataggca gaaaaagatc    24060

atggagtcag tcgagaagaa ggacagccta accgccccct ctgagttcgc caccaccgcc    24120

tccaccgatg ccgccaacgc gcctaccacc ttccccgtcg aggcaccccc gcttgaggag    24180

gaggaagtga ttatcgagca ggacccaggt tttgtaagcg aagacgacga ggaccgctca    24240

gtaccaacag aggataaaaa gcaagaccag gacaacgcag aggcaaacga ggaacaagtc    24300

gggcgggggg acgaaaggca tggcgactac ctagatgtgg gagacgacgt gctgttgaag    24360

catctgcagc gccagtgcgc cattatctgc gacgcgttgc aagagcgcag cgatgtgccc    24420

ctcgccatag cggatgtcag ccttgcctac gaacgccacc tattctcacc gcgcgtaccc    24480

cccaaacgcc aagaaaacgg cacatgcgag cccaacccgc gcctcaactt ctaccccgta    24540

tttgccgtgc cagaggtgct tgccacctat cacatctttt tccaaaactg caagataccc    24600

ctatcctgcc gtgccaaccg cagccgagcg gacaagcagc tggccttgcg gcagggcgct    24660

gtcatacctg atatcgcctc gctcaacgaa gtgccaaaaa tctttgaggg tcttggacgc    24720

gacgagaagc gcgcggcaaa cgctctgcaa caggaaaaca gcgaaaatga aagtcactct    24780

ggagtgttgg tggaactcga gggtgacaac gcgcgcctag ccgtactaaa acgcagcatc    24840

gaggtcaccc actttgccta cccggcactt aacctacccc ccaaggtcat gagcacagtc    24900

atgagtgagc tgatcgtgcg ccgtgcgcag cccctggaga gggatgcaaa tttgcaagaa    24960

caaacagagg agggcctacc cgcagttggc gacgagcagc tagcgcgctg gcttcaaacg    25020

cgcgagcctg ccgacttgga ggagcgacgc aaactaatga tggccgcagt gctcgttacc    25080

gtggagcttg agtgcatgca gcggttcttt gctgacccgg agatgcagcg caagctagag    25140

gaaacattgc actacacctt tcgacagggc tacgtacgcc aggcctgcaa gatctccaac    25200

gtggagctct gcaacctggt ctcctacctt ggaattttgc acgaaaaccg ccttgggcaa    25260

aacgtgcttc attccacgct caagggcgag gcgcgccgcg actacgtccg cgactgcgtt    25320

tacttatttc tatgctacac ctggcagacg gccatgggcg tttggcagca gtgcttggag    25380

gagtgcaacc tcaaggagct gcagaaactg ctaaagcaaa acttgaagga cctatggacg    25440

gccttcaacg agcgctccgt ggccgcgcac ctggcggaca tcattttccc cgaacgcctg    25500

cttaaaaccc tgcaacaggg tctgccagac ttcaccagtc aaagcatgtt gcagaacttt    25560

aggaacttta tcctagagcg ctcaggaatc ttgcccgcca cctgctgtgc acttcctagc    25620

gactttgtgc ccattaagta ccgcgaatgc cctccgccgc tttggggcca ctgctacctt    25680

ctgcagctag ccaactacct tgcctaccac tctgacataa tggaagacgt gagcggtgac    25740

ggtctactgg agtgtcactg tcgctgcaac ctatgcaccc cgcaccgctc cctggtttgc    25800

aattcgcagc tgcttaacga aagtcaaatt atcggtacct ttgagctgca gggtccctcg    25860

cctgacgaaa agtccgcggc tccggggttg aaactcactc cggggctgtg gacgtcggct    25920

taccttcgca aatttgtacc tgaggactac cacgcccacg agattaggtt ctacgaagac    25980

caatcccgcc cgccaaatgc ggagcttacc gcctgcgtca ttacccaggg ccacattctt    26040

ggccaattgc aagccatcaa caaagcccgc caagagtttc tgctacgaaa gggacggggg    26100

gtttacttgg acccccagtc cggcgaggag ctcaacccaa tccccccgcc gccgcagccc    26160

tatcagcagc agccgcgggc ccttgcttcc caggatggca cccaaaaaga agctgcagct    26220

gccgccgcca cccacggacg aggaggaata ctgggacagt caggcagagg aggttttgga    26280

cgaggaggag gaggacatga tggaagactg ggagagccta gacgaggaag cttccgaggt    26340

cgaagaggtg tcagacgaaa caccgtcacc ctcggtcgca ttcccctcgc cggcgcccca    26400

gaaatcggca accggttcca gcatggctac aacctccgct cctcaggcgc cgccggcact    26460

gcccgttcgc cgacccaacc gtagatggga caccactgga accagggccg gtaagtccaa    26520

gcagccgccg ccgttagccc aagagcaaca acagcgccaa ggctaccgct catggcgcgg    26580

gcacaagaac gccatagttg cttgcttgca agactgtggg ggcaacatct ccttcgcccg    26640

ccgctttctt ctctaccatc acggcgtggc cttcccccgt aacatcctgc attactaccg    26700

tcatctctac agcccatact gcaccggcgg cagcggcagc ggcagcaaca gcagcggcca    26760

cacagaagca aaggcgaccg gatagcaaga ctctgacaaa gcccaagaaa tccacagcgg    26820

cggcagcagc aggaggagga gcgctgcgtc tggcgcccaa cgaacccgta tcgacccgcg    26880

agcttagaaa caggattttt cccactctgt atgctatatt tcaacagagc aggggccaag    26940

aacaagagct gaaaataaaa aacaggtctc tgcgatccct cacccgcagc tgcctgtatc    27000

acaaaagcga agatcagctt cggcgcacgc tggaagacgc ggaggctctc ttcagtaaat    27060

actgcgcgct gactcttaag gactagtttc gcgccctttc tcaaatttaa gcgcgaaaac    27120

tacgtcatct ccagcggcca cacccggcgc cagcacctgt cgtcagcgcc attatgagca    27180

aggaaattcc cacgccctac atgtggagtt accagccaca aatgggactt gcggctggag    27240

ctgcccaaga ctactcaacc cgaataaact acatgagcgc gggaccccac atgatatccc    27300

gggtcaacgg aatccgcgcc caccgaaacc gaattctctt ggaacaggcg gctattacca    27360

ccacacctcg taataacctt aatccccgta gttggcccgc tgccctggtg taccaggaaa    27420

gtcccgctcc caccactgtg gtacttccca gagacgccca ggccgaagtt cagatgacta    27480

actcaggggc gcagcttgcg ggcggctttc gtcacagggt gcggtcgccc gggcagggta    27540

taactcacct gacaatcaga gggcgaggta ttcagctcaa cgacgagtcg gtgagctcct    27600

cgcttggtct ccgtccggac gggacatttc agatcggcgg cgccggccgt ccttcattca    27660

cgcctcgtca ggcaatccta actctgcaga cctcgtcctc tgagccgcgc tctggaggca    27720

ttggaactct gcaatttatt gaggagtttg tgccatcggt ctactttaac cccttctcgg    27780

gacctcccgg ccactatccg gatcaattta ttcctaactt tgacgcggta aaggactcgg    27840

cggacggcta cgactgaatg ttaagtggag aggcagagca actgcgcctg aaacacctgg    27900

tccactgtcg ccgccacaag tgctttgccc gcgactccgg tgagttttgc tactttgaat    27960

tgcccgagga tcatatcgag ggcccggcgc acggcgtccg gcttaccgcc cagggagagc    28020

ttgcccgtag cctgattcgg gagtttaccc agcgccccct gctagttgag cgggacaggg    28080

gaccctgtgt tctcactgtg atttgcaact gtcctaacct tggattacat caagatcttt    28140

gttgccatct ctgtgctgag tataataaat acagaaatta aaatatactg gggctcctat    28200

cgccatcctg taaacgccac cgtcttcacc cgcccaagca aaccaaggcg aaccttacct    28260

ggtactttta acatctctcc ctctgtgatt tacaacagtt tcaacccaga cggagtgagt    28320

ctacgagaga acctctccga gctcagctac tccatcagaa aaaacaccac cctccttacc    28380

tgccgggaac gtacgagtgc gtcaccggcc gctgcaccac acctaccgcc tgaccgtaaa    28440

ccagactttt tccggacaga cctcaataac tctgtttacc agaacaggag gtgagcttag    28500

aaaaccctta gggtattagg ccaaaggcgc agctactgtg gggtttatga acaattcaag    28560

caactctacg ggctattcta attcaggttt ctctagaatc ggggttgggg ttattctctg    28620

tcttgtgatt ctctttattc ttatactaac gcttctctgc ctaaggctcg ccgcctgctg    28680

tgtgcacatt tgcatttatt gtcagctttt taaacgctgg ggtcgccacc caagatgatt    28740

aggtacataa tcctaggttt actcaccctt gcgtcagccc acggtaccac ccaaaaggtg    28800

gattttaagg agccagcctg taatgttaca ttcgcagctg aagctaatga gtgcaccact    28860

cttataaaat gcaccacaga acatgaaaag ctgcttattc gccacaaaaa caaaattggc    28920

aagtatgctg tttatgctat ttggcagcca ggtgacacta cagagtataa tgttacagtt    28980

ttccagggta aaagtcataa aacttttatg tatacttttc cattttatga aatgtgcgac    29040

attaccatgt acatgagcaa acagtataag ttgtggcccc cacaaaattg tgtggaaaac    29100

actggcactt tctgctgcac tgctatgcta attacagtgc tcgctttggt ctgtacccta    29160

ctctatatta aatacaaaag cagacgcagc tttattgagg aaaagaaaat gccttaattt    29220

actaagttac aaagctaatg tcaccactaa ctgctttact cgctgcttgc aaaacaaatt    29280

caaaaagtta gcattataat tagaatagga tttaaacccc ccggtcattt cctgctcaat    29340

accattcccc tgaacaattg actctatgtg ggatatgctc cagcgctaca accttgaagt    29400

caggcttcct ggatgtcagc atctgacttt ggccagcacc tgtcccgcgg atttgttcca    29460

gtccaactac agcgacccac cctaacagag atgaccaaca caaccaacgc ggccgccgct    29520

accggactta catctaccac aaatacaccc caagtttctg cctttgtcaa taactgggat    29580

aacttgggca tgtggtggtt ctccatagcg cttatgtttg tatgccttat tattatgtgg    29640

ctcatctgct gcctaaagcg caaacgcgcc cgaccaccca tctatagtcc catcattgtg    29700

ctacacccaa acaatgatgg aatccataga ttggacggac tgaaacacat gttcttttct    29760

cttacagtat gattaaatga gacatgattc ctcgagtttt tatattactg acccttgttg    29820

cgcttttttg tgcgtgctcc acattggctg cggtttctca catcgaagta gactgcattc    29880

cagccttcac agtctatttg ctttacggat ttgtcaccct cacgctcatc tgcagcctca    29940

tcactgtggt catcgccttt atccagtgca ttgactgggt ctgtgtgcgc tttgcatatc    30000

tcagacacca tccccagtac agggacagga ctatagctga gcttcttaga attctttaat    30060

tatgaaattt actgtgactt ttctgctgat tatttgcacc ctatctgcgt tttgttcccc    30120

gacctccaag cctcaaagac atatatcatg cagattcact cgtatatgga atattccaag    30180

ttgctacaat gaaaaaagcg atctttccga agcctggtta tatgcaatca tctctgttat    30240

ggtgttctgc agtaccatct tagccctagc tatatatccc taccttgaca ttggctggaa    30300

acgaatagat gccatgaacc acccaacttt ccccgcgccc gctatgcttc cactgcaaca    30360

agttgttgcc ggcggctttg tcccagccaa tcagcctcgc cccacttctc ccacccccac    30420

tgaaatcagc tactttaatc taacaggagg agatgactga caccctagat ctagaaatgg    30480

acggaattat tacagagcag cgcctgctag aaagacgcag ggcagcggcc gagcaacagc    30540

gcatgaatca agagctccaa gacatggtta acttgcacca gtgcaaaagg ggtatctttt    30600

gtctggtaaa gcaggccaaa gtcacctacg acagtaatac caccggacac cgccttagct    30660

acaagttgcc aaccaagcgt cagaaattgg tggtcatggt gggagaaaag cccattacca    30720

taactcagca ctcggtagaa accgaaggct gcattcactc accttgtcaa ggacctgagg    30780

atctctgcac ccttattaag accctgtgcg gtctcaaaga tcttattccc tttaactaat    30840

aaaaaaaaat aataaagcat cacttactta aaatcagtta gcaaatttct gtccagttta    30900

ttcagcagca cctccttgcc ctcctcccag ctctggtatt gcagcttcct cctggctgca    30960

aactttctcc acaatctaaa tggaatgtca gtttcctcct gttcctgtcc atccgcaccc    31020

actatcttca tgttgttgca gatgaagcgc gcaagaccgt ctgaagatac cttcaacccc    31080

gtgtatccat atgacacgga aaccggtcct ccaactgtgc cttttcttac tcctcccttt    31140

gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg cctatccgaa    31200

cctctagtta cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct ctctctggac    31260

gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct caaaaaaacc    31320

aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga agccctaact    31380

gtggctgccg ccgcacctct aatggtcgcg ggcaacacac tcaccatgca atcacaggcc    31440

ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct cacagtgtca    31500

gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag cagtaccctt    31560

actatcactg cctcaccccc tctaactact gccactggta gcttgggcat tgacttgaaa    31620

gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc tttgcatgta    31680

acagacgacc taaacacttt gaccgtagca actggtccag gtgtgactat taataatact    31740

tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa tatgcaactt    31800

aatgtagcag gaggactaag gattgattct caaaacagac gccttatact tgatgttagt    31860

tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc tctttttata    31920

aactcagccc acaacttgga tattaactac aacaaaggcc tttacttgtt tacagcttca    31980

aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat gtttgacgct    32040

acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa tgcaccaaac    32100

acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa caaggctatg    32160

gttcctaaac taggaactgg ccttagtttt gacagcacag gtgccattac agtaggaaac    32220

aaaaataatg ataagctaac tttgtggacc acaccagctc catctcctaa ctgtagacta    32280

aatgcagaga aagatgctaa actcactttg gtcttaacaa aatgtggcag tcaaatactt    32340

gctacagttt cagttttggc tgttaaaggc agtttggctc caatatctgg aacagttcaa    32400

agtgctcatc ttattataag atttgacgaa aatggagtgc tactaaacaa ttccttcctg    32460

gacccagaat attggaactt tagaaatgga gatcttactg aaggcacagc ctatacaaac    32520

gctgttggat ttatgcctaa cctatcagct tatccaaaat ctcacggtaa aactgccaaa    32580

agtaacattg tcagtcaagt ttacttaaac ggagacaaaa ctaaacctgt aacactaacc    32640

attacactaa acggtacaca ggaaacagga gacacaactc caagtgcata ctctatgtca    32700

ttttcatggg actggtctgg ccacaactac attaatgaaa tatttgccac atcctcttac    32760

actttttcat acattgccca agaataaaga atcgtttgtg ttatgtttca acgtgtttat    32820

ttttcaattg cagaaaattt caagtcattt ttcattcagt agtatagccc caccaccaca    32880

tagcttatac agatcaccgt accttaatca aactcacaga accctagtat tcaacctgcc    32940

acctccctcc caacacacag agtacacagt cctttctccc cggctggcct taaaaagcat    33000

catatcatgg gtaacagaca tattcttagg tgttatattc cacacggttt cctgtcgagc    33060

caaacgctca tcagtgatat taataaactc cccgggcagc tcacttaagt tcatgtcgct    33120

gtccagctgc tgagccacag gctgctgtcc aacttgcggt tgcttaacgg gcggcgaagg    33180

agaagtccac gcctacatgg gggtagagtc ataatcgtgc atcaggatag ggcggtggtg    33240

ctgcagcagc gcgcgaataa actgctgccg ccgccgctcc gtcctgcagg aatacaacat    33300

ggcagtggtc tcctcagcga tgattcgcac cgcccgcagc ataaggcgcc ttgtcctccg    33360

ggcacagcag cgcaccctga tctcacttaa atcagcacag taactgcagc acagcaccac    33420

aatattgttc aaaatcccac agtgcaaggc gctgtatcca aagctcatgg cggggaccac    33480

agaacccacg tggccatcat accacaagcg caggtagatt aagtggcgac ccctcataaa    33540

cacgctggac ataaacatta cctcttttgg catgttgtaa ttcaccacct cccggtacca    33600

tataaacctc tgattaaaca tggcgccatc caccaccatc ctaaaccagc tggccaaaac    33660

ctgcccgccg gctatacact gcagggaacc gggactggaa caatgacagt ggagagccca    33720

ggactcgtaa ccatggatca tcatgctcgt catgatatca atgttggcac aacacaggca    33780

cacgtgcata cacttcctca ggattacaag ctcctcccgc gttagaacca tatcccaggg    33840

aacaacccat tcctgaatca gcgtaaatcc cacactgcag ggaagacctc gcacgtaact    33900

cacgttgtgc attgtcaaag tgttacattc gggcagcagc ggatgatcct ccagtatggt    33960

agcgcgggtt tctgtctcaa aaggaggtag acgatcccta ctgtacggag tgcgccgaga    34020

caaccgagat cgtgttggtc gtagtgtcat gccaaatgga acgccggacg tagtcatatt    34080

tcctgaagca aaaccaggtg cgggcgtgac aaacagatct gcgtctccgg tctcgccgct    34140

tagatcgctc tgtgtagtag ttgtagtata tccactctct caaagcatcc aggcgccccc    34200

tggcttcggg ttctatgtaa actccttcat gcgccgctgc cctgataaca tccaccaccg    34260

cagaataagc cacacccagc caacctacac attcgttctg cgagtcacac acgggaggag    34320

cgggaagagc tggaagaacc atgttttttt ttttattcca aaagattatc caaaacctca    34380

aaatgaagat ctattaagtg aacgcgctcc cctccggtgg cgtggtcaaa ctctacagcc    34440

aaagaacaga taatggcatt tgtaagatgt tgcacaatgg cttccaaaag gcaaacggcc    34500

ctcacgtcca agtggacgta aaggctaaac ccttcagggt gaatctcctc tataaacatt    34560

ccagcacctt caaccatgcc caaataattc tcatctcgcc accttctcaa tatatctcta    34620

agcaaatccc gaatattaag tccggccatt gtaaaaatct gctccagagc gccctccacc    34680

ttcagcctca agcagcgaat catgattgca aaaattcagg ttcctcacag acctgtataa    34740

gattcaaaag cggaacatta acaaaaatac cgcgatcccg taggtccctt cgcagggcca    34800

gctgaacata atcgtgcagg tctgcacgga ccagcgcggc cacttccccg ccaggaacca    34860

tgacaaaaga acccacactg attatgacac gcatactcgg agctatgcta accagcgtag    34920

ccccgatgta agcttgttgc atgggcggcg atataaaatg caaggtgctg ctcaaaaaat    34980

caggcaaagc ctcgcgcaaa aaagaaagca catcgtagtc atgctcatgc agataaaggc    35040

aggtaagctc cggaaccacc acagaaaaag acaccatttt tctctcaaac atgtctgcgg    35100

gtttctgcat aaacacaaaa taaaataaca aaaaaacatt taaacattag aagcctgtct    35160

tacaacagga aaaacaaccc ttataagcat aagacggact acggccatgc cggcgtgacc    35220

gtaaaaaaac tggtcaccgt gattaaaaag caccaccgac agctcctcgg tcatgtccgg    35280

agtcataatg taagactcgg taaacacatc aggttgattc acatcggtca gtgctaaaaa    35340

gcgaccgaaa tagcccgggg gaatacatac ccgcaggcgt agagacaaca ttacagcccc    35400

cataggaggt ataacaaaat taataggaga gaaaaacaca taaacacctg aaaaaccctc    35460

ctgcctaggc aaaatagcac cctcccgctc cagaacaaca tacagcgctt ccacagcggc    35520

agccataaca gtcagcctta ccagtaaaaa agaaaaccta ttaaaaaaac accactcgac    35580

acggcaccag ctcaatcagt cacagtgtaa aaaagggcca agtgcagagc gagtatatat    35640

aggactaaaa aatgacgtaa cggttaaagt ccacaaaaaa cacccagaaa accgcacgcg    35700

aacctacgcc cagaaacgaa agccaaaaaa cccacaactt cctcaaatcg tcacttccgt    35760

tttcccacgt tacgtaactt cccattttaa gaaaactaca attcccaaca catacaagtt    35820

actccgccct aaaacctacg tcacccgccc cgttcccacg ccccgcgcca cgtcacaaac    35880

tccaccccct cattatcata ttggcttcaa tccaaaataa ggtatattat tgatgatg      35938


<210>  24
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified E3 region

<400>  24
ttattgagga aaagaaaatg ccttaataaa aaaaaataat aaagcatcac ttac             54


<210>  25
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified E4 region

<400>  25
gaacgccgga cgtagtcata acagtcagcc ttaccagtaa a                           41


<210>  26
<211>  4509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine CD80 - EMCV IRES - CD137L - FMDV IRES - ICAM-1 cloned into
       modified E1b-19k region with flanking adenoviral sequences

<400>  26
atctgacctc gtcgacatgg cttgcaattg tcagttgatg caggatacac cactcctcaa       60

gtttccatgt ccaaggctca ttcttctctt tgtgctgctg attcgtcttt cacaagtgtc      120

ttcagatgtt gatgaacaac tgtccaagtc agtgaaagat aaggtattgc tgccttgccg      180

ttacaactct cctcatgaag atgagtctga agaccgaatc tactggcaaa aacatgacaa      240

agtggtgctg tctgtcattg ctgggaaact aaaagtgtgg cccgagtata agaaccggac      300

tttatatgac aacactacct actctcttat catcctgggc ctggtccttt cagaccgggg      360

cacatacagc tgtgtcgttc aaaagaagga aagaggaacg tatgaagtta aacacttggc      420

tttagtaaag ttgtccatca aagctgactt ctctaccccc aacataactg agtctggaaa      480

cccatctgca gacactaaaa ggattacctg ctttgcttcc gggggtttcc caaagcctcg      540

cttctcttgg ttggaaaatg gaagagaatt acctggcatc aatacgacaa tttcccagga      600

tcctgaatct gaattgtaca ccattagtag ccaactagat ttcaatacga ctcgcaacca      660

caccattaag tgtctcatta aatatggaga tgctcacgtg tcagaggact tcacctggga      720

aaaaccccca gaagaccctc ctgatagcaa gaacacactt gtgctctttg gggcaggatt      780

cggcgcagta ataacagtcg tcgtcatcgt tgtcatcatc aaatgcttct gtaagcacag      840

aagctgtttc agaagaaatg aggcaagcag agaaacaaac aacagcctta ccttcgggcc      900

tgaagaagca ttagctgaac agaccgtctt cctttagtaa cgttactggc cgaagccgct      960

tggaataagg ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg     1020

gcaatgtgag ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt     1080

cccctctcgc caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg     1140

aagcttcttg aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac     1200

ctggcgacag gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg     1260

cacaacccca gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct     1320

caagcgtatt caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg     1380

atctggggcc tcggtgcaca tgctttacat gtgtttagtc gaggttaaaa aacgtctagg     1440

ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat atggaccagc     1500

acacacttga tgtggaggat accgcggatg ccagacatcc agcaggtact tcgtgcccct     1560

cggatgcggc gctcctcaga gataccgggc tcctcgcgga cgctgcgctc ctctcagata     1620

ctgtgcgccc cacaaatgcc gcgctcccca cggatgctgc ctaccctgcg gttaatgttc     1680

gggatcgcga ggccgcgtgg ccgcctgcac tgaacttctg ttcccgccac ccaaagctct     1740

atggcctagt cgctttggtt ttgctgcttc tgatcgccgc ctgtgttcct atcttcaccc     1800

gcaccgagcc tcggccagcg ctcacaatca ccacctcgcc caacctgggt acccgagaga     1860

ataatgcaga ccaggtcacc cctgtttccc acattggctg ccccaacact acacaacagg     1920

gctctcctgt gttcgccaag ctactggcta aaaaccaagc atcgttgtgc aatacaactc     1980

tgaactggca cagccaagat ggagctggga gctcatacct atctcaaggt ctgaggtacg     2040

aagaagacaa aaaggagttg gtggtagaca gtcccgggct ctactacgta tttttggaac     2100

tgaagctcag tccaacattc acaaacacag gccacaaggt gcagggctgg gtctctcttg     2160

ttttgcaagc aaagcctcag gtagatgact ttgacaactt ggccctgaca gtggaactgt     2220

tcccttgctc catggagaac aagttagtgg accgttcctg gagtcaactg ttgctcctga     2280

aggctggcca ccgcctcagt gtgggtctga gggcttatct gcatggagcc caggatgcat     2340

acagagactg ggagctgtct tatcccaaca ccaccagctt tggactcttt cttgtgaaac     2400

ccgacaaccc atgggaatga ggtttccaca actgataaaa ctcgtgcaac ttgaaactcc     2460

gcctggtctt tccaggtcta gaggggttac actttgtact gtgctcgact ccacgcccgg     2520

tccactggcg ggtgttagta gcagcactgt tgtttcgtag cggagcatgg tggccgtggg     2580

aactcctcct tggtgacaag ggcccacggg gccgaaagcc acgtccagac ggacccacca     2640

tgtgtgcaac cccagcacgg caacttttac tgcgaacacc accttaaggt gacactggta     2700

ctggtactcg gtcactggtg acaggctaag gatgcccttc aggtaccccg aggtaacacg     2760

ggacactcgg gatctgagaa ggggattggg acttctttaa aagtgcccag tttaaaaagc     2820

ttctacgcct gaataggcga ccggaggccg gcgcctttcc attacccact actaaatcca     2880

tggcttcaac ccgtgccaag cccacgctac ctctgctcct ggccctggtc accgttgtga     2940

tccctgggcc tggtgatgct caggtatcca tccatcccag agaagccttc ctgccccagg     3000

gtgggtccgt gcaggtgaac tgttcttcct catgcaagga ggacctcagc ctgggcttgg     3060

agactcagtg gctgaaagat gagctcgaga gtggacccaa ctggaagctg tttgagctga     3120

gcgagatcgg ggaggacagc agtccgctgt gctttgagaa ctgtggcacc gtgcagtcgt     3180

ccgcttccgc taccatcacc gtgtattcgt ttccggagag tgtggagctg agacctctgc     3240

cagcctggca gcaagtaggc aaggacctca ccctgcgctg ccacgtggat ggtggagcac     3300

cgcggaccca gctctcagca gtgctgctcc gtggggagga gatactgagc cgccagccag     3360

tgggtgggca ccccaaggac cccaaggaga tcacattcac ggtgctggct agcagagggg     3420

accacggagc caatttctca tgccgcacag aactggatct caggccgcaa gggctggcat     3480

tgttctctaa tgtctccgag gccaggagcc tccggacttt cgatcttcca gctaccatcc     3540

caaagctcga cacccctgac ctcctggagg tgggcaccca gcagaagttg ttttgctccc     3600

tggaaggcct gtttcctgcc tctgaagctc ggatatacct ggagctggga ggccagatgc     3660

cgacccagga gagcacaaac agcagtgact ctgtgtcagc cactgccttg gtagaggtga     3720

ctgaggagtt cgacagaacc ctgccgctgc gctgcgtttt ggagctagcg gaccagatcc     3780

tggagacgca gaggacctta acagtctaca acttttcagc tccggtcctg accctgagcc     3840

agctggaggt ctcggaaggg agccaagtaa ctgtgaagtg tgaagcccac agtgggtcga     3900

aggtggttct tctgagcggc gtcgagccta ggccacccac cccgcaggtc caattcacac     3960

tgaatgccag ctcggaggat cacaaacgaa gcttcttttg ctctgccgct ctggaggtgg     4020

cgggaaagtt cctgtttaaa aaccagaccc tggaactgca cgtgctgtat ggtcctcggc     4080

tggacgagac ggactgcttg gggaactgga cctggcaaga ggggtctcag cagactctga     4140

aatgccaggc ctgggggaac ccatctccta agatgacctg cagacggaag gcagatggtg     4200

ccctgctgcc catcggggtg gtgaagtctg tcaaacagga gatgaatggt acatacgtgt     4260

gccatgcctt tagctcccat gggaatgtca ccaggaatgt gtacctgaca gtactgtacc     4320

actctcaaaa taactggact ataatcattc tggtgccagt actgctggtc attgtgggcc     4380

tcgtgatggc agcctcttat gtttataacc gccagagaaa gatcaggata tacaagttac     4440

agaaggctca ggaggaggcc ataaaactca agggacaagc cccacctccc tgactcgagt     4500

caccaggcg                                                             4509


<210>  27
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD80 - IRES - CD137L cloned into modified E1b-19k region 
       with flanking adenoviral sequences

<400>  27
gcgccgtggg ctaatcttgg ttacatctga cctcgtcgac atgggccaca cacggaggca       60

gggaacatca ccatccaagt gtccatacct caatttcttt cagctcttgg tgctggctgg      120

tctttctcac ttctgttcag gtgttatcca cgtgaccaag gaagtgaaag aagtggcaac      180

gctgtcctgt ggtcacaatg tttctgttga agagctggca caaactcgca tctactggca      240

aaaggagaag aaaatggtgc tgactatgat gtctggggac atgaatatat ggcccgagta      300

caagaaccgg accatctttg atatcactaa taacctctcc attgtgatcc tggctctgcg      360

cccatctgac gagggcacat acgagtgtgt tgttctgaag tatgaaaaag acgctttcaa      420

gcgggaacac ctggctgaag tgacgttatc agtcaaagct gacttcccta cacctagtat      480

atctgacttt gaaattccaa cttctaatat tagaaggata atttgctcaa cctctggagg      540

ttttccagag cctcacctct cctggttgga aaatggagaa gaattaaatg ccatcaacac      600

aacagtttcc caagatcctg aaactgagct ctatgctgtt agcagcaaac tggatttcaa      660

tatgacaacc aaccacagct tcatgtgtct catcaagtat ggacatttaa gagtgaatca      720

gaccttcaac tggaatacaa ccaagcaaga gcattttcct gataacctgc tcccatcctg      780

ggccattacc ttaatctcag taaatggaat ttttgtgata tgctgcctga cctactgctt      840

tgccccaaga tgcagagaga gaaggaggaa tgagagattg agaagggaaa gtgtacgccc      900

tgtataataa cgttactggc cgaagccgct tggaataagg ccggtgtgcg tttgtctata      960

tgttattttc caccatattg ccgtcttttg gcaatgtgag ggcccggaaa cctggccctg     1020

tcttcttgac gagcattcct aggggtcttt cccctctcgc caaaggaatg caaggtctgt     1080

tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg aagacaaaca acgtctgtag     1140

cgaccctttg caggcagcgg aaccccccac ctggcgacag gtgcctctgc ggccaaaagc     1200

cacgtgtata agatacacct gcaaaggcgg cacaacccca gtgccacgtt gtgagttgga     1260

tagttgtgga aagagtcaaa tggctctcct caagcgtatt caacaagggg ctgaaggatg     1320

cccagaaggt accccattgt atgggatctg atctggggcc tcggtgcaca tgctttacat     1380

gtgtttagtc gaggttaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct     1440

ttgaaaaaca cgatgataat atggaatacg cctctgacgc ttcactggac cccgaagccc     1500

cgtggcctcc tgcacctcgc gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg     1560

ggctgctgct cctgctcctg ctcgctgctg catgcgctgt atttcttgca tgcccatggg     1620

ctgtgtctgg ggctcgcgca tcacctggct ccgcggccag cccgagactc cgcgagggtc     1680

ccgagctttc gcccgacgat cccgccggcc tcttggacct gcggcagggc atgtttgcgc     1740

agctggtggc ccaaaatgtt ctgctgatcg atgggcccct gagctggtac agtgacccag     1800

gcctggcagg cgtgtccctg acggggggcc tgagctacaa agaggacacg aaggagctgg     1860

tggtggccaa ggctggagtc tactatgtct tctttcaact agagctgcgg cgcgtggtgg     1920

ccggcgaggg ctcaggctcc gtttcacttg cgctgcacct gcagccactg cgctctgctg     1980

ctggggccgc cgccctggct ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga     2040

actcggcctt cggtttccag ggccgcttgc tgcacctgag tgccggccag cgcctgggcg     2100

tccatcttca cactgaggcc agggcacgcc atgcctggca gcttacccag ggcgccacag     2160

tcttgggact cttccgggtg acccccgaaa tcccagccgg actcccttca ccgaggtcgg     2220


<210>  28
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence resulting from TAV-255 deletion

<400>  28
ggtgttttgg                                                              10


<210>  29
<211>  8
<212>  DNA
<213>  Adenovirus type 5

<400>  29
tgccttaa                                                                 8


<210>  30
<211>  11
<212>  DNA
<213>  Adenovirus type 5

<400>  30
taaaaaaaaa t                                                            11


<210>  31
<211>  4275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human CD80 - EMCV IRES - CD137L - FMDV IRES - ICAM-1 cloned into 
       modified E1b-19k region with flanking adenoviral sequences

<400>  31
atctgacctc gtcgacatgg gccacacacg gaggcaggga acatcaccat ccaagtgtcc       60

atacctcaat ttctttcagc tcttggtgct ggctggtctt tctcacttct gttcaggtgt      120

tatccacgtg accaaggaag tgaaagaagt ggcaacgctg tcctgtggtc acaatgtttc      180

tgttgaagag ctggcacaaa ctcgcatcta ctggcaaaag gagaagaaaa tggtgctgac      240

tatgatgtct ggggacatga atatatggcc cgagtacaag aaccggacca tctttgatat      300

cactaataac ctctccattg tgatcctggc tctgcgccca tctgacgagg gcacatacga      360

gtgtgttgtt ctgaagtatg aaaaagacgc tttcaagcgg gaacacctgg ctgaagtgac      420

gttatcagtc aaagctgact tccctacacc tagtatatct gactttgaaa ttccaacttc      480

taatattaga aggataattt gctcaacctc tggaggtttt ccagagcctc acctctcctg      540

gttggaaaat ggagaagaat taaatgccat caacacaaca gtttcccaag atcctgaaac      600

tgagctctat gctgttagca gcaaactgga tttcaatatg acaaccaacc acagcttcat      660

gtgtctcatc aagtatggac atttaagagt gaatcagacc ttcaactgga atacaaccaa      720

gcaagagcat tttcctgata acctgctccc atcctgggcc attaccttaa tctcagtaaa      780

tggaattttt gtgatatgct gcctgaccta ctgctttgcc ccaagatgca gagagagaag      840

gaggaatgag agattgagaa gggaaagtgt acgccctgta taataacgtt actggccgaa      900

gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc atattgccgt      960

cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc attcctaggg     1020

gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc     1080

ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg cagcggaacc     1140

ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat acacctgcaa     1200

aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga gtcaaatggc     1260

tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc cattgtatgg     1320

gatctgatct ggggcctcgg tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaacg     1380

tctaggcccc ccgaaccacg gggacgtggt tttcctttga aaaacacgat gataatatgg     1440

aatacgcctc tgacgcttca ctggaccccg aagccccgtg gcctcctgca cctcgcgctc     1500

gcgcctgccg cgtactgcct tgggccctgg tcgcggggct gctgctcctg ctcctgctcg     1560

ctgctgcatg cgctgtattt cttgcatgcc catgggctgt gtctggggct cgcgcatcac     1620

ctggctccgc ggccagcccg agactccgcg agggtcccga gctttcgccc gacgatcccg     1680

ccggcctctt ggacctgcgg cagggcatgt ttgcgcagct ggtggcccaa aatgttctgc     1740

tgatcgatgg gcccctgagc tggtacagtg acccaggcct ggcaggcgtg tccctgacgg     1800

ggggcctgag ctacaaagag gacacgaagg agctggtggt ggccaaggct ggagtctact     1860

atgtcttctt tcaactagag ctgcggcgcg tggtggccgg cgagggctca ggctccgttt     1920

cacttgcgct gcacctgcag ccactgcgct ctgctgctgg ggccgccgcc ctggctttga     1980

ccgtggacct gccacccgcc tcctccgagg ctcggaactc ggccttcggt ttccagggcc     2040

gcttgctgca cctgagtgcc ggccagcgcc tgggcgtcca tcttcacact gaggccaggg     2100

cacgccatgc ctggcagctt acccagggcg ccacagtctt gggactcttc cgggtgaccc     2160

ccgaaatccc agccggactc ccttcaccga ggtcggaata aggtttccac aactgataaa     2220

actcgtgcaa cttgaaactc cgcctggtct ttccaggtct agaggggtta cactttgtac     2280

tgtgctcgac tccacgcccg gtccactggc gggtgttagt agcagcactg ttgtttcgta     2340

gcggagcatg gtggccgtgg gaactcctcc ttggtgacaa gggcccacgg ggccgaaagc     2400

cacgtccaga cggacccacc atgtgtgcaa ccccagcacg gcaactttta ctgcgaacac     2460

caccttaagg tgacactggt actggtactc ggtcactggt gacaggctaa ggatgccctt     2520

caggtacccc gaggtaacac gggacactcg ggatctgaga aggggattgg gacttcttta     2580

aaagtgccca gtttaaaaag cttctacgcc tgaataggcg accggaggcc ggcgcctttc     2640

cattacccac tactaaatcc atggctccca gcagcccccg gcccgcgctg cccgcactcc     2700

tggtcctgct cggggctctg ttcccaggac ctggcaatgc ccagacatct gtgtccccct     2760

caaaagtcat cctgccccgg ggaggctccg tgctggtgac atgcagcacc tcctgtgacc     2820

agcccaagtt gttgggcata gagaccccgt tgcctaaaaa ggagttgctc ctgcctggga     2880

acaaccggaa ggtgtatgaa ctgagcaatg tgcaagaaga tagccaacca atgtgctatt     2940

caaactgccc tgatgggcag tcaacagcta aaaccttcct caccgtgtac tggactccag     3000

aacgggtgga actggcaccc ctcccctctt ggcagccagt gggcaagaac cttaccctac     3060

gctgccaggt ggagggtggg gcaccccggg ccaacctcac cgtggtgctg ctccgtgggg     3120

agaaggagct gaaacgggag ccagctgtgg gggagcccgc tgaggtcacg accacggtgc     3180

tggtgaggag agatcaccat ggagccaatt tctcgtgccg cactgaactg gacctgcggc     3240

cccaagggct ggagctgttt gagaacacct cggcccccta ccagctccag acctttgtcc     3300

tgccagcgac tcccccacaa cttgtcagcc cccgggtcct agaggtggac acgcagggga     3360

ccgtggtctg ttccctggac gggctgttcc cagtctcgga ggcccaggtc cacctggcac     3420

tgggggacca gaggttgaac cccacagtca cctatggcaa cgactccttc tcggccaagg     3480

cctcagtcag tgtgaccgca gaggacgagg gcacccagcg gctgacgtgt gcagtaatac     3540

tggggaacca gagccaggag acactgcaga cagtgaccat ctacagcttt ccggcgccca     3600

acgtgattct gacgaagcca gaggtctcag aagggaccga ggtgacagtg aagtgtgagg     3660

cccaccctag agccaaggtg acgctgaatg gggttccagc ccagccactg ggcccgaggg     3720

cccagctcct gctgaaggcc accccagagg acaacgggcg cagcttctcc tgctctgcaa     3780

ccctggaggt ggccggccag cttatacaca agaaccagac ccgggagctt cgtgtcctgt     3840

atggcccccg actggacgag agggattgtc cgggaaactg gacgtggcca gaaaattccc     3900

agcagactcc aatgtgccag gcttggggga acccattgcc cgagctcaag tgtctaaagg     3960

atggcacttt cccactgccc atcggggaat cagtgactgt cactcgagat cttgagggca     4020

cctacctctg tcgggccagg agcactcaag gggaggtcac ccgcaaggtg accgtgaatg     4080

tgctctcccc ccggtatgag attgtcatca tcactgtggt agcagccgca gtcataatgg     4140

gcactgcagg cctcagcacg tacctctata accgccagcg gaagatcaag aaatacagac     4200

tacaacaggc ccaaaaaggg acccccatga aaccgaacac acaagccacg cctccctgac     4260

tcgagtcacc aggcg                                                      4275


<210>  32
<211>  1599
<212>  DNA
<213>  Homo sapiens

<400>  32
atggctccca gcagcccccg gcccgcgctg cccgcactcc tggtcctgct cggggctctg       60

ttcccaggac ctggcaatgc ccagacatct gtgtccccct caaaagtcat cctgccccgg      120

ggaggctccg tgctggtgac atgcagcacc tcctgtgacc agcccaagtt gttgggcata      180

gagaccccgt tgcctaaaaa ggagttgctc ctgcctggga acaaccggaa ggtgtatgaa      240

ctgagcaatg tgcaagaaga tagccaacca atgtgctatt caaactgccc tgatgggcag      300

tcaacagcta aaaccttcct caccgtgtac tggactccag aacgggtgga actggcaccc      360

ctcccctctt ggcagccagt gggcaagaac cttaccctac gctgccaggt ggagggtggg      420

gcaccccggg ccaacctcac cgtggtgctg ctccgtgggg agaaggagct gaaacgggag      480

ccagctgtgg gggagcccgc tgaggtcacg accacggtgc tggtgaggag agatcaccat      540

ggagccaatt tctcgtgccg cactgaactg gacctgcggc cccaagggct ggagctgttt      600

gagaacacct cggcccccta ccagctccag acctttgtcc tgccagcgac tcccccacaa      660

cttgtcagcc cccgggtcct agaggtggac acgcagggga ccgtggtctg ttccctggac      720

gggctgttcc cagtctcgga ggcccaggtc cacctggcac tgggggacca gaggttgaac      780

cccacagtca cctatggcaa cgactccttc tcggccaagg cctcagtcag tgtgaccgca      840

gaggacgagg gcacccagcg gctgacgtgt gcagtaatac tggggaacca gagccaggag      900

acactgcaga cagtgaccat ctacagcttt ccggcgccca acgtgattct gacgaagcca      960

gaggtctcag aagggaccga ggtgacagtg aagtgtgagg cccaccctag agccaaggtg     1020

acgctgaatg gggttccagc ccagccactg ggcccgaggg cccagctcct gctgaaggcc     1080

accccagagg acaacgggcg cagcttctcc tgctctgcaa ccctggaggt ggccggccag     1140

cttatacaca agaaccagac ccgggagctt cgtgtcctgt atggcccccg actggacgag     1200

agggattgtc cgggaaactg gacgtggcca gaaaattccc agcagactcc aatgtgccag     1260

gcttggggga acccattgcc cgagctcaag tgtctaaagg atggcacttt cccactgccc     1320

atcggggaat cagtgactgt cactcgagat cttgagggca cctacctctg tcgggccagg     1380

agcactcaag gggaggtcac ccgcaaggtg accgtgaatg tgctctcccc ccggtatgag     1440

attgtcatca tcactgtggt agcagccgca gtcataatgg gcactgcagg cctcagcacg     1500

tacctctata accgccagcg gaagatcaag aaatacagac tacaacaggc ccaaaaaggg     1560

acccccatga aaccgaacac acaagccacg cctccctga                            1599


<210>  33
<211>  1516
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Pro Tyr Pro Cys Gly Cys His Ile Leu Leu Leu Leu Phe Cys 
1               5                   10                  15      


Cys Leu Ala Ala Ala Arg Ala Asn Leu Leu Asn Leu Asn Trp Leu Trp 
            20                  25                  30          


Phe Asn Asn Glu Asp Thr Ser His Ala Ala Thr Thr Ile Pro Glu Pro 
        35                  40                  45              


Gln Gly Pro Leu Pro Val Gln Pro Thr Ala Asp Thr Thr Thr His Val 
    50                  55                  60                  


Thr Pro Arg Asn Gly Ser Thr Glu Pro Ala Thr Ala Pro Gly Ser Pro 
65                  70                  75                  80  


Glu Pro Pro Ser Glu Leu Leu Glu Asp Gly Gln Asp Thr Pro Thr Ser 
                85                  90                  95      


Ala Glu Ser Pro Asp Ala Pro Glu Glu Asn Ile Ala Gly Val Gly Ala 
            100                 105                 110         


Glu Ile Leu Asn Val Ala Lys Gly Ile Arg Ser Phe Val Gln Leu Trp 
        115                 120                 125             


Asn Asp Thr Val Pro Thr Glu Ser Leu Ala Arg Ala Glu Thr Leu Val 
    130                 135                 140                 


Leu Glu Thr Pro Val Gly Pro Leu Ala Leu Ala Gly Pro Ser Ser Thr 
145                 150                 155                 160 


Pro Gln Glu Asn Gly Thr Thr Leu Trp Pro Ser Arg Gly Ile Pro Ser 
                165                 170                 175     


Ser Pro Gly Ala His Thr Thr Glu Ala Gly Thr Leu Pro Ala Pro Thr 
            180                 185                 190         


Pro Ser Pro Pro Ser Leu Gly Arg Pro Trp Ala Pro Leu Thr Gly Pro 
        195                 200                 205             


Ser Val Pro Pro Pro Ser Ser Glu Arg Ile Ser Glu Glu Val Gly Leu 
    210                 215                 220                 


Leu Gln Leu Leu Gly Asp Pro Pro Pro Gln Gln Val Thr Gln Thr Asp 
225                 230                 235                 240 


Asp Pro Asp Val Gly Leu Ala Tyr Val Phe Gly Pro Asp Ala Asn Ser 
                245                 250                 255     


Gly Gln Val Ala Arg Tyr His Phe Pro Ser Leu Phe Phe Arg Asp Phe 
            260                 265                 270         


Ser Leu Leu Phe His Ile Arg Pro Ala Thr Glu Gly Pro Gly Val Leu 
        275                 280                 285             


Phe Ala Ile Thr Asp Ser Ala Gln Ala Met Val Leu Leu Gly Val Lys 
    290                 295                 300                 


Leu Ser Gly Val Gln Asp Gly His Gln Asp Ile Ser Leu Leu Tyr Thr 
305                 310                 315                 320 


Glu Pro Gly Ala Gly Gln Thr His Thr Ala Ala Ser Phe Arg Leu Pro 
                325                 330                 335     


Ala Phe Val Gly Gln Trp Thr His Leu Ala Leu Ser Val Ala Gly Gly 
            340                 345                 350         


Phe Val Ala Leu Tyr Val Asp Cys Glu Glu Phe Gln Arg Met Pro Leu 
        355                 360                 365             


Ala Arg Ser Ser Arg Gly Leu Glu Leu Glu Pro Gly Ala Gly Leu Phe 
    370                 375                 380                 


Val Ala Gln Ala Gly Gly Ala Asp Pro Asp Lys Phe Gln Gly Val Ile 
385                 390                 395                 400 


Ala Glu Leu Lys Val Arg Arg Asp Pro Gln Val Ser Pro Met His Cys 
                405                 410                 415     


Leu Asp Glu Glu Gly Asp Asp Ser Asp Gly Ala Ser Gly Asp Ser Gly 
            420                 425                 430         


Ser Gly Leu Gly Asp Ala Arg Glu Leu Leu Arg Glu Glu Thr Gly Ala 
        435                 440                 445             


Ala Leu Lys Pro Arg Leu Pro Ala Pro Pro Pro Val Thr Thr Pro Pro 
    450                 455                 460                 


Leu Ala Gly Gly Ser Ser Thr Glu Asp Ser Arg Ser Glu Glu Val Glu 
465                 470                 475                 480 


Glu Gln Thr Thr Val Ala Ser Leu Gly Ala Gln Thr Leu Pro Gly Ser 
                485                 490                 495     


Asp Ser Val Ser Thr Trp Asp Gly Ser Val Arg Thr Pro Gly Gly Arg 
            500                 505                 510         


Val Lys Glu Gly Gly Leu Lys Gly Gln Lys Gly Glu Pro Gly Val Pro 
        515                 520                 525             


Gly Pro Pro Gly Arg Ala Gly Pro Pro Gly Ser Pro Cys Leu Pro Gly 
    530                 535                 540                 


Pro Pro Gly Leu Pro Cys Pro Val Ser Pro Leu Gly Pro Ala Gly Pro 
545                 550                 555                 560 


Ala Leu Gln Thr Val Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly 
                565                 570                 575     


Arg Asp Gly Thr Pro Gly Arg Asp Gly Glu Pro Gly Asp Pro Gly Glu 
            580                 585                 590         


Asp Gly Lys Pro Gly Asp Thr Gly Pro Gln Gly Phe Pro Gly Thr Pro 
        595                 600                 605             


Gly Asp Val Gly Pro Lys Gly Asp Lys Gly Asp Pro Gly Val Gly Glu 
    610                 615                 620                 


Arg Gly Pro Pro Gly Pro Gln Gly Pro Pro Gly Pro Pro Gly Pro Ser 
625                 630                 635                 640 


Phe Arg His Asp Lys Leu Thr Phe Ile Asp Met Glu Gly Ser Gly Phe 
                645                 650                 655     


Gly Gly Asp Leu Glu Ala Leu Arg Gly Pro Arg Gly Phe Pro Gly Pro 
            660                 665                 670         


Pro Gly Pro Pro Gly Val Pro Gly Leu Pro Gly Glu Pro Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Ser Ser Asp Val Pro Gly Pro Ala Gly Leu Pro Gly Val 
    690                 695                 700                 


Pro Gly Arg Glu Gly Pro Pro Gly Phe Pro Gly Leu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Pro Pro Gly Arg Glu Gly Pro Pro Gly Arg Thr Gly Gln Lys Gly 
                725                 730                 735     


Ser Leu Gly Glu Ala Gly Ala Pro Gly His Lys Gly Ser Lys Gly Ala 
            740                 745                 750         


Pro Gly Pro Ala Gly Ala Arg Gly Glu Ser Gly Leu Ala Gly Ala Pro 
        755                 760                 765             


Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    770                 775                 780                 


Pro Gly Leu Pro Ala Gly Phe Asp Asp Met Glu Gly Ser Gly Gly Pro 
785                 790                 795                 800 


Phe Trp Ser Thr Ala Arg Ser Ala Asp Gly Pro Gln Gly Pro Pro Gly 
                805                 810                 815     


Leu Pro Gly Leu Lys Gly Asp Pro Gly Val Pro Gly Leu Pro Gly Ala 
            820                 825                 830         


Lys Gly Glu Val Gly Ala Asp Gly Val Pro Gly Phe Pro Gly Leu Pro 
        835                 840                 845             


Gly Arg Glu Gly Ile Ala Gly Pro Gln Gly Pro Lys Gly Asp Arg Gly 
    850                 855                 860                 


Ser Arg Gly Glu Lys Gly Asp Pro Gly Lys Asp Gly Val Gly Gln Pro 
865                 870                 875                 880 


Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Pro Val Val Tyr Val Ser 
                885                 890                 895     


Glu Gln Asp Gly Ser Val Leu Ser Val Pro Gly Pro Glu Gly Arg Pro 
            900                 905                 910         


Gly Phe Ala Gly Phe Pro Gly Pro Ala Gly Pro Lys Gly Asn Leu Gly 
        915                 920                 925             


Ser Lys Gly Glu Arg Gly Ser Pro Gly Pro Lys Gly Glu Lys Gly Glu 
    930                 935                 940                 


Pro Gly Ser Ile Phe Ser Pro Asp Gly Gly Ala Leu Gly Pro Ala Gln 
945                 950                 955                 960 


Lys Gly Ala Lys Gly Glu Pro Gly Phe Arg Gly Pro Pro Gly Pro Tyr 
                965                 970                 975     


Gly Arg Pro Gly Tyr Lys Gly Glu Ile Gly Phe Pro Gly Arg Pro Gly 
            980                 985                 990         


Arg Pro Gly Met Asn Gly Leu Lys  Gly Glu Lys Gly Glu  Pro Gly Asp 
        995                 1000                 1005             


Ala Ser  Leu Gly Phe Gly Met  Arg Gly Met Pro Gly  Pro Pro Gly 
    1010                 1015                 1020             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Thr Pro Val  Tyr Asp Ser 
    1025                 1030                 1035             


Asn Val  Phe Ala Glu Ser Ser  Arg Pro Gly Pro Pro  Gly Leu Pro 
    1040                 1045                 1050             


Gly Asn  Gln Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Glu Val 
    1055                 1060                 1065             


Gly Pro  Pro Gly Pro Pro Gly  Gln Phe Pro Phe Asp  Phe Leu Gln 
    1070                 1075                 1080             


Leu Glu  Ala Glu Met Lys Gly  Glu Lys Gly Asp Arg  Gly Asp Ala 
    1085                 1090                 1095             


Gly Gln  Lys Gly Glu Arg Gly  Glu Pro Gly Gly Gly  Gly Phe Phe 
    1100                 1105                 1110             


Gly Ser  Ser Leu Pro Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly 
    1115                 1120                 1125             


Tyr Pro  Gly Ile Pro Gly Pro  Lys Gly Glu Ser Ile  Arg Gly Gln 
    1130                 1135                 1140             


Pro Gly  Pro Pro Gly Pro Gln  Gly Pro Pro Gly Ile  Gly Tyr Glu 
    1145                 1150                 1155             


Gly Arg  Gln Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1160                 1165                 1170             


Ser Phe  Pro Gly Pro His Arg  Gln Thr Ile Ser Val  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro Gly Thr  Met Gly Ala 
    1190                 1195                 1200             


Ser Ser  Gly Val Arg Leu Trp  Ala Thr Arg Gln Ala  Met Leu Gly 
    1205                 1210                 1215             


Gln Val  His Glu Val Pro Glu  Gly Trp Leu Ile Phe  Val Ala Glu 
    1220                 1225                 1230             


Gln Glu  Glu Leu Tyr Val Arg  Val Gln Asn Gly Phe  Arg Lys Val 
    1235                 1240                 1245             


Gln Leu  Glu Ala Arg Thr Pro  Leu Pro Arg Gly Thr  Asp Asn Glu 
    1250                 1255                 1260             


Val Ala  Ala Leu Gln Pro Pro  Val Val Gln Leu His  Asp Ser Asn 
    1265                 1270                 1275             


Pro Tyr  Pro Arg Arg Glu His  Pro His Pro Thr Ala  Arg Pro Trp 
    1280                 1285                 1290             


Arg Ala  Asp Asp Ile Leu Ala  Ser Pro Pro Arg Leu  Pro Glu Pro 
    1295                 1300                 1305             


Gln Pro  Tyr Pro Gly Ala Pro  His His Ser Ser Tyr  Val His Leu 
    1310                 1315                 1320             


Arg Pro  Ala Arg Pro Thr Ser  Pro Pro Ala His Ser  His Arg Asp 
    1325                 1330                 1335             


Phe Gln  Pro Val Leu His Leu  Val Ala Leu Asn Ser  Pro Leu Ser 
    1340                 1345                 1350             


Gly Gly  Met Arg Gly Ile Arg  Gly Ala Asp Phe Gln  Cys Phe Gln 
    1355                 1360                 1365             


Gln Ala  Arg Ala Val Gly Leu  Ala Gly Thr Phe Arg  Ala Phe Leu 
    1370                 1375                 1380             


Ser Ser  Arg Leu Gln Asp Leu  Tyr Ser Ile Val Arg  Arg Ala Asp 
    1385                 1390                 1395             


Arg Ala  Ala Val Pro Ile Val  Asn Leu Lys Asp Glu  Leu Leu Phe 
    1400                 1405                 1410             


Pro Ser  Trp Glu Ala Leu Phe  Ser Gly Ser Glu Gly  Pro Leu Lys 
    1415                 1420                 1425             


Pro Gly  Ala Arg Ile Phe Ser  Phe Asp Gly Lys Asp  Val Leu Arg 
    1430                 1435                 1440             


His Pro  Thr Trp Pro Gln Lys  Ser Val Trp His Gly  Ser Asp Pro 
    1445                 1450                 1455             


Asn Gly  Arg Arg Leu Thr Glu  Ser Tyr Cys Glu Thr  Trp Arg Thr 
    1460                 1465                 1470             


Glu Ala  Pro Ser Ala Thr Gly  Gln Ala Ser Ser Leu  Leu Gly Gly 
    1475                 1480                 1485             


Arg Leu  Leu Gly Gln Ser Ala  Ala Ser Cys His His  Ala Tyr Ile 
    1490                 1495                 1500             


Val Leu  Cys Ile Glu Asn Ser  Phe Met Thr Ala Ser  Lys 
    1505                 1510                 1515     


<210>  34
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  35
<211>  2673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human endostatin - IRES - angiostatin cloned into modified 
       E1b-19k region with flanking adenoviral sequences

<400>  35
atctgacctc gtcgacatgg ctccctaccc ctgtggctgc cacatcctgc tgctgctctt       60

ctgctgcctg gcggctgccc gggccagctc ctacgtgcac ctgcggccgg cgcgacccac      120

aagcccaccc gcccacagcc accgcgactt ccagccggtg ctccacctgg ttgcgctcaa      180

cagccccctg tcaggcggca tgcggggcat ccgcggggcc gacttccagt gcttccagca      240

ggcgcgggcc gtggggctgg cgggcacctt ccgcgccttc ctgtcctcgc gcctgcagga      300

cctgtacagc atcgtgcgcc gtgccgaccg cgcagccgtg cccatcgtca acctcaagga      360

cgagctgctg tttcccagct gggaggctct gttctcaggc tctgagggtc cgctgaagcc      420

cggggcacgc atcttctcct ttgacggcaa ggacgtcctg aggcacccca cctggcccca      480

gaagagcgtg tggcatggct cggaccccaa cgggcgcagg ctgaccgaga gctactgtga      540

gacgtggcgg acggaggctc cctcggccac gggccaggcc tcctcgctgc tggggggcag      600

gctcctgggg cagagtgccg cgagctgcca tcacgcctac atcgtgctct gcattgagaa      660

cagcttcatg actgcctcca agtagtaacg ttactggccg aagccgcttg gaataaggcc      720

ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg      780

cccggaaacc tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca      840

aaggaatgca aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa      900

gacaaacaac gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt      960

gcctctgcgg ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt     1020

gccacgttgt gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca     1080

acaaggggct gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc     1140

ggtgcacatg ctttacatgt gtttagtcga ggttaaaaaa cgtctaggcc ccccgaacca     1200

cggggacgtg gttttccttt gaaaaacacg atgataatat ggaacataag gaagtggttc     1260

ttctacttct tttatttctg aaatcaggtc aaggaaaagt gtatctctca gagtgcaaga     1320

ctgggaatgg aaagaactac agagggacga tgtccaaaac aaaaaatggc atcacctgtc     1380

aaaaatggag ttccacttct ccccacagac ctagattctc acctgctaca cacccctcag     1440

agggactgga ggagaactac tgcaggaatc cagacaacga tccgcagggg ccctggtgct     1500

atactactga tccagaaaag agatatgact actgcgacat tcttgagtgt gaagaggaat     1560

gtatgcattg cagtggagaa aactatgacg gcaaaatttc caagaccatg tctggactgg     1620

aatgccaggc ctgggactct cagagcccac acgctcatgg atacattcct tccaaatttc     1680

caaacaagaa cctgaagaag aattactgtc gtaaccccga tagggagctg cggccttggt     1740

gtttcaccac cgaccccaac aagcgctggg aactttgtga catcccccgc tgcacaacac     1800

ctccaccatc ttctggtccc acctaccagt gtctgaaggg aacaggtgaa aactatcgcg     1860

ggaatgtggc tgttaccgtg tccgggcaca cctgtcagca ctggagtgca cagacccctc     1920

acacacataa caggacacca gaaaacttcc cctgcaaaaa tttggatgaa aactactgcc     1980

gcaatcctga cggaaaaagg gccccatggt gccatacaac caacagccaa gtgcggtggg     2040

agtactgtaa gataccgtcc tgtgactcct ccccagtatc cacggaacaa ttggctccca     2100

cagcaccacc tgagctaacc cctgtggtcc aggactgcta ccatggtgat ggacagagct     2160

accgaggcac atcctccacc accaccacag gaaagaagtg tcagtcttgg tcatctatga     2220

caccacaccg gcaccagaag accccagaaa actacccaaa tgctggcctg acaatgaact     2280

actgcaggaa tccagatgcc gataaaggcc cctggtgttt taccacagac cccagcgtca     2340

ggtgggagta ctgcaacctg aaaaaatgct caggaacaga agcgagtgtt gtagcacctc     2400

cgcctgttgt cctgcttcca gatgtagaga ctccttccga agaagactgt atgtttggga     2460

atgggaaagg ataccgaggc aagagggcga ccactgttac tgggacgcca tgccaggact     2520

gggctgccca ggagccccat agacacagca ttttcactcc agagacaaat ccacgggcgg     2580

gtctggaaaa aaattactgc cgtaaccctg atggtgatgt aggtggtccc tggtgctaca     2640

cgacaaatcc aagatagctc gagtcaccag gcg                                  2673


<210>  36
<211>  2685
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine endostatin - IRES - angiostatin cloned into modified 
       E1b-19k region with flanking adenoviral sequences

<400>  36
atctgacctc gtcgacatgg ctcccgaccc cagcagacgc ctctgcctgc tgctgctgtt       60

gctgctctcc tgccgccttg tgcctgccag cgcttatgtg cacctgccgc cagcccgccc      120

caccctctca cttgctcata ctcatcagga ctttcagcca gtgctccacc tggtggcact      180

gaacaccccc ctgtctggag gcatgcgtgg tatccgtgga gcagatttcc agtgcttcca      240

gcaagcccga gccgtggggc tgtcgggcac cttccgggct ttcctgtcct ctaggctgca      300

ggatctctat agcatcgtgc gccgtgctga ccgggggtct gtgcccatcg tcaacctgaa      360

ggacgaggtg ctatctccca gctgggactc cctgttttct ggctcccagg gtcaactgca      420

acccggggcc cgcatctttt cttttgacgg cagagatgtc ctgagacacc cagcctggcc      480

gcagaagagc gtatggcacg gctcggaccc cagtgggcgg aggctgatgg agagttactg      540

tgagacatgg cgaactgaaa ctactggggc tacaggtcag gcctcctccc tgctgtcagg      600

caggctcctg gaacagaaag ctgcgagctg ccacaacagc tacatcgtcc tgtgcattga      660

gaatagcttc atgacctctt tctccaaata gtaacgttac tggccgaagc cgcttggaat      720

aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct tttggcaatg      780

tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt ctttcccctc      840

tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct ctggaagctt      900

cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc ccacctggcg      960

acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag gcggcacaac     1020

cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc tcctcaagcg     1080

tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga tctgatctgg     1140

ggcctcggtg cacatgcttt acatgtgttt agtcgaggtt aaaaaacgtc taggcccccc     1200

gaaccacggg gacgtggttt tcctttgaaa aacacgatga taatatggac cacaaggaag     1260

taatccttct gtttctcttg cttctgaaac caggacaagg gaagagagtg tatctgtcag     1320

aatgtaagac cggcatcggc aacggctaca gaggaacaat gtccaggaca aagagtggtg     1380

ttgcctgtca aaagtggggt gccacgttcc cccacgtacc caactactct cccagtacac     1440

atcccaatga gggactagaa gaaaattact gtaggaaccc agacaatgat gaacaagggc     1500

cttggtgcta cactacagat ccggacaaga gatatgacta ctgcaacatt cctgaatgtg     1560

aagaagaatg catgtactgc agtggcgaaa agtatgaggg gaaaatctcc aagaccatgt     1620

ctggacttga ctgccaggcc tgggattctc agagcccaca tgctcatgga tacatccctg     1680

ccaaattccc aagcaagaac ctgaagatga attattgccg caaccctgac ggggagccaa     1740

ggccctggtg cttcacaaca gaccccacca aacgctggga atactgtgac atcccccgct     1800

gcacaacacc cccgccccca cccagcccaa cctaccaatg tctgaaagga agaggtgaaa     1860

attaccgagg gaccgtgtct gtcaccgtgt ctgggaaaac ctgtcagcgc tggagtgagc     1920

aaacccctca taggcacaac aggacaccag aaaatttccc ctgcaaaaat ctggaggaga     1980

attactgccg gaacccggat ggagaaactg ctccctggtg ctataccact gacagccagc     2040

tgaggtggga gtactgtgag attccatcct gcgagtcctc agcatcacca gaccagtcag     2100

attcctcagt tccaccagag gagcaaacac ctgtggtcca ggaatgctac cagagcgatg     2160

ggcagagcta tcggggtaca tcgtccacta ccatcacagg gaagaagtgc cagtcctggg     2220

cagctatgtt tccacatagg cattcgaaga cgccagagaa cttcccagat gctggcttgg     2280

agatgaacta ttgcaggaac ccggatggtg acaagggccc ttggtgctac accactgacc     2340

cgagcgtcag gtgggaatac tgcaacctga agcggtgctc agagacagga gggagtgttg     2400

tggaattgcc cacagtttcc caggaaccaa gtgggccgag cgactctgag acagactgca     2460

tgtatgggaa tggcaaagac taccggggca aaacggccgt cactgcagct ggcacccctt     2520

gccaaggatg ggctgcccag gagccccaca ggcacagcat cttcacccca cagacaaacc     2580

cacgggcagg tctggaaaag aattattgcc gaaaccccga tggggatgtg aatggtcctt     2640

ggtgctatac aacaaaccct agatgatagc tcgagtcacc aggcg                     2685


<210>  37
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly 
1               5                   10                  15      


Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala Arg 
            20                  25                  30          


Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser Arg Leu 
        35                  40                  45              


Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala Val Pro 
    50                  55                  60                  


Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu 
65                  70                  75                  80  


Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro Gly Ala Arg Ile Phe Ser 
                85                  90                  95      


Phe Asp Gly Lys Asp 
            100     


<210>  38
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Ser Tyr Val His Leu Arg Pro Ala Arg Pro Thr Ser Pro Pro Ala 
1               5                   10                  15      


His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
            20                  25                  30          


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
        35                  40                  45              


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
    50                  55                  60                  


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
65                  70                  75                  80  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
                85                  90                  95      


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
            100                 105                 110         


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
        115                 120                 125             


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
    130                 135                 140                 


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
145                 150                 155                 160 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
                165                 170                 175     


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
            180                 185                 190         


Ser Phe Met Thr Ala Ser Lys 
        195                 


<210>  39
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly Thr Met Ser 
1               5                   10                  15      


Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser Thr Ser Pro 
            20                  25                  30          


His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu Gly Leu Glu 
        35                  40                  45              


Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly Pro Trp Cys 
    50                  55                  60                  


Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp Ile Leu Glu 
65                  70                  75                  80  


Cys Glu Glu 
            


<210>  40
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  40

Glu Glu Cys Met His Cys Ser Gly Glu Asn Tyr Asp Gly Lys Ile Ser 
1               5                   10                  15      


Lys Thr Met Ser Gly Leu Glu Cys Gln Ala Trp Asp Ser Gln Ser Pro 
            20                  25                  30          


His Ala His Gly Tyr Ile Pro Ser Lys Phe Pro Asn Lys Asn Leu Lys 
        35                  40                  45              


Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu Leu Arg Pro Trp Cys Phe 
    50                  55                  60                  


Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu Cys Asp Ile Pro Arg Cys 
65                  70                  75                  80  


Thr 
    


<210>  41
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  41

Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
1               5                   10                  15      


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
            20                  25                  30          


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
        35                  40                  45              


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
    50                  55                  60                  


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
65                  70                  75                  80  


Asp Ser 
        


<210>  42
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly Thr Ser Ser 
1               5                   10                  15      


Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser Met Thr Pro 
            20                  25                  30          


His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala Gly Leu Thr 
        35                  40                  45              


Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro Trp Cys Phe 
    50                  55                  60                  


Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu Lys Lys Cys 
65                  70                  75                  80  


Ser Gly 
        


<210>  43
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala 
1               5                   10                  15      


Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro 
            20                  25                  30          


His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu 
        35                  40                  45              


Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp 
    50                  55                  60                  


Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro 
65                  70                  75                  80  


Gln Cys 
        


<210>  44
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  44

Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
1               5                   10                  15      


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
            20                  25                  30          


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
        35                  40                  45              


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
    50                  55                  60                  


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
65                  70                  75                  80  


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
                85                  90                  95      


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
            100                 105                 110         


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
        115                 120                 125             


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
    130                 135                 140                 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
145                 150                 155                 160 


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
                165                 170                 175     


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
            180                 185                 190         


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
        195                 200                 205             


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
    210                 215                 220                 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
225                 230                 235                 240 


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
                245                 250                 255     


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
            260                 265                 270         


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
        275                 280                 285             


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
    290                 295                 300                 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
305                 310                 315                 320 


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
                325                 330                 335     


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
            340                 345                 350         


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
        355                 360                 365             


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
    370                 375                 380                 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
385                 390                 395                 400 


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
                405                 410                 415     


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Thr Asn Pro Arg 
    450             


