                               SEQUENCE LISTING

<110> OTONOMY, INC.
 
<120> NEUROTROPHIN MUTANTS FOR TREATING HEARING LOSS AND OTHER OTIC 
      DISORDERS

<130> 37173-835.601

<140> PCT/US2018/015548
<141> 2018-01-26

<150> 62/451,570
<151> 2017-01-27

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          


Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  


Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  


Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      


Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         


Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 


<210> 2
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Asp Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210> 3
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Gly Val Ser Glu Thr Ala Pro Ala Ser Arg Arg Gly Glu Leu Ala Val 
1               5                   10                  15      


Cys Asp Ala Val Ser Gly Trp Val Thr Asp Arg Arg Thr Ala Val Asp 
            20                  25                  30          


Leu Arg Gly Arg Glu Val Glu Val Leu Gly Glu Val Pro Ala Ala Gly 
        35                  40                  45              


Gly Ser Pro Leu Arg Gln Tyr Phe Phe Glu Thr Arg Cys Lys Ala Asp 
    50                  55                  60                  


Asn Ala Glu Glu Gly Gly Pro Gly Ala Gly Gly Gly Gly Cys Arg Gly 
65                  70                  75                  80  


Val Asp Arg Arg His Trp Val Ser Glu Cys Lys Ala Lys Gln Ser Tyr 
                85                  90                  95      


Val Arg Ala Leu Thr Ala Asp Ala Gln Gly Arg Val Gly Trp Arg Trp 
            100                 105                 110         


Ile Arg Ile Asp Thr Ala Cys Val Cys Thr Leu Leu Ser Arg Thr Gly 
        115                 120                 125             


Arg Ala 
    130 


<210> 4
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
1               5                   10                  15      


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
            20                  25                  30          


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
        35                  40                  45              


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
            100                 105                 110         


Leu Thr Ile Lys Arg Gly Arg 
        115                 


<210> 5
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg 
            20                  25                  30          


Gly His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Arg Lys Ile Gly Arg Thr 
        115                 120 


<210> 6
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          


Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val 
            100                 105                 110         


Leu Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120     


<210> 7
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
            20                  25                  30          


Met Ser Gly Gly Thr Val Met Val Leu Gly Glu Val Asn Ile Asn Asn 
        35                  40                  45              


Ser Val Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Asn Pro Met Gly 
    50                  55                  60                  


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser 
65                  70                  75                  80  


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
                85                  90                  95      


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val 
            100                 105                 110         


Cys Val Leu Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120             


<210> 8
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Ser Ser Ser His Pro Ile Ala His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          


Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  


Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  


Thr Thr Thr Ala Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      


Ala Ala Trp Arg Phe Ile Ala Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         


Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 


<210> 9
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Ser Ser Ser His Pro Ile Ala His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Lys 
            20                  25                  30          


Gly Lys Glu Val Met Val Leu Gly Glu Val Asn Ile Ala Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  


Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  


Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      


Ala Ala Trp Arg Phe Ile Ala Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         


Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 


<210> 10
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Ser Ser Ser His Pro Ile Ala His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Ala 
            20                  25                  30          


Gly Ala Ala Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  


Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  


Thr Thr Thr Ala Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      


Ala Ala Trp Arg Phe Ile Ala Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         


Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 


<210> 11
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Ser Ser Ser His Pro Ile Ala His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Ala 
            20                  25                  30          


Gly Ala Ala Val Met Val Leu Gly Glu Val Asn Ile Ala Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val 
    50                  55                  60                  


Asp Ser Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys 
65                  70                  75                  80  


Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln 
                85                  90                  95      


Ala Ala Trp Arg Phe Ile Ala Ile Asp Thr Ala Cys Val Cys Val Leu 
            100                 105                 110         


Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120 


<210> 12
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Ser Ser Ser His Pro Ile Phe His Val Cys Asp Ser Val Ser Val Trp 
1               5                   10                  15      


Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Ala Gly Ala Ala Val Met 
            20                  25                  30          


Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val Phe Lys Gln Tyr Phe 
        35                  40                  45              


Phe Glu Thr Lys Cys Arg Asp Pro Asn Pro Val Asp Ser Gly Cys Arg 
    50                  55                  60                  


Gly Ile Asp Ser Lys His Trp Asn Ser Tyr Cys Thr Thr Thr His Thr 
65                  70                  75                  80  


Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln Ala Ala Trp Arg Phe 
                85                  90                  95      


Ile Arg Ile Asp Thr Ala Cys Val Cys Val Leu Ser Arg Lys Ala Val 
            100                 105                 110         


Arg Arg Ala 
        115 


<210> 13
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Ala 
            20                  25                  30          


Gly Ala Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Arg Lys Ile Gly Arg Thr 
        115                 120 


<210> 14
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg 
            20                  25                  30          


Gly His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Ala Ala Trp Ala Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Arg Lys Ile Gly Arg Thr 
        115                 120 


<210> 15
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg 
            20                  25                  30          


Gly His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Ala Ala Ile Gly Arg Thr 
        115                 120 


<210> 16
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Ala 
            20                  25                  30          


Gly Ala Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Ala Ala Trp Ala Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Ala Ala Ile Gly Arg Thr 
        115                 120 


<210> 17
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Gly Asp Lys Thr Thr Ala Thr Asp Ile Ala 
            20                  25                  30          


Gly Ala Ala Val Met Val Leu Gly Glu Val Asn Ile Asn Asn Ser Val 
        35                  40                  45              


Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
    50                  55                  60                  


Lys Glu Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val Cys Val 
            100                 105                 110         


Leu Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120     


<210> 18
<211> 123
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Phe Ser Val Cys Asp 
1               5                   10                  15      


Ser Val Ser Val Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp 
            20                  25                  30          


Met Ala Gly Ala Ala Val Met Val Leu Gly Glu Val Asn Ile Asn Asn 
        35                  40                  45              


Ser Val Phe Lys Gln Tyr Phe Phe Glu Thr Lys Cys Asn Pro Met Gly 
    50                  55                  60                  


Tyr Thr Lys Glu Gly Cys Arg Gly Ile Asp Ser Lys His Trp Asn Ser 
65                  70                  75                  80  


Gln Cys Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser 
                85                  90                  95      


Lys Lys Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Val 
            100                 105                 110         


Cys Val Leu Ser Arg Lys Ala Val Arg Arg Ala 
        115                 120             


<210> 19
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Ala 
            20                  25                  30          


Gly Ala Ala Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Arg Lys Ile Gly Arg Thr 
        115                 120 


<210> 20
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg 
            20                  25                  30          


Gly His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ser Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Glu Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Arg Lys Ile Gly Arg Thr 
        115                 120 


<210> 21
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Ser Ser Ser His Pro Ile Phe His Arg Gly Glu Tyr Ser Val Cys Asp 
1               5                   10                  15      


Ser Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg 
            20                  25                  30          


Gly His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro 
        35                  40                  45              


Val Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val 
    50                  55                  60                  


Lys Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys 
65                  70                  75                  80  


Lys Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Ser Lys Lys 
                85                  90                  95      


Arg Ile Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala 
            100                 105                 110         


Leu Ser Arg Lys Ile Ala Arg Thr 
        115                 120 


<210> 22
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Ala Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210> 23
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 24
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Tyr Ala Glu His Lys Ser His Arg Gly Glu Ala Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Ala Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Ala Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 25
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Ala Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Ala Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 26
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Tyr Ala Glu His Lys Ser His Arg Gly Glu Ala Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Ala Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 27
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Ala Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 28
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Tyr Ala Glu His Lys Ser His Arg Gly Glu Ala Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 29
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Ala Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Ala Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210> 30
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Ala Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 31
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210> 32
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Asp Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Arg Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Ala Ala Ile Gly Arg Thr 
        115                 


<210> 33
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Ala Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Glu Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


<210> 34
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Tyr Ala Glu His Lys Ser His Arg Gly Glu Tyr Ser Val Cys Ala Ser 
1               5                   10                  15      


Glu Ser Leu Trp Val Thr Asp Lys Ser Ser Ala Ile Asp Ile Ala Gly 
            20                  25                  30          


His Gln Val Thr Val Leu Gly Ala Ile Lys Thr Gly Asn Ser Pro Val 
        35                  40                  45              


Lys Gln Tyr Phe Tyr Glu Thr Arg Cys Lys Glu Ala Arg Pro Val Lys 
    50                  55                  60                  


Asn Gly Cys Arg Gly Ile Asp Asp Lys His Trp Asn Ser Gln Cys Lys 
65                  70                  75                  80  


Thr Ser Gln Thr Tyr Val Arg Ala Leu Thr Ser Glu Asn Asn Lys Leu 
                85                  90                  95      


Val Gly Trp Arg Trp Ile Arg Ile Asp Thr Ser Cys Val Cys Ala Leu 
            100                 105                 110         


Ser Arg Lys Ile Gly Arg Thr 
        115                 


