
                                SEQUENCE LISTING

<110> RUDOLF, Martin
      ROIZMAN, Keith
      CURCIO, Christine A.
      SILBER, B. Michael
      

<120> TREATMENT OF AGE-RELATED MACULAR
  DEGENERATION AND OTHER EYE DISEASES WITH APOLIPOPROTEIN
  MIMETICS

<130> 774462000140

<140> PCT/US2017/014754  
<141> 2017-01-24  

<160> 32

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> AMIDATION      
<222> 23

<400> 1
Cys Gly Val Leu Glu Ser Phe Lys Ala Ser Phe Leu Ser Ala Leu Glu
 1               5                  10                  15      
Glu Trp Thr Lys Lys Leu Gln
            20              


<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu
 1               5                  10                  15      


<210> 3
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu
 1               5                  10                  15      


<210> 4
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu
 1               5                  10                  15      
Ala Phe
        


<210> 5
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu
 1               5                  10                  15      
Ala Phe Pro Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys
            20                  25                  30          
Leu Lys Glu Ala Phe
        35          


<210> 6
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu
 1               5                  10                  15      
Phe Phe Pro Asp Trp Leu Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys
            20                  25                  30          
Leu Lys Glu Phe Phe
        35          


<210> 7
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Leu Lys Glu
 1               5                  10                  15      
Ala Phe Pro Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys
            20                  25                  30          
Leu Lys Glu Ala Phe
        35          


<210> 8
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Asp Lys Leu Lys Ala Phe Tyr Asp Lys Val Phe Glu Trp Ala Lys Glu
 1               5                  10                  15      
Ala Phe Pro Asp Lys Leu Lys Ala Phe Tyr Asp Lys Val Phe Glu Trp
            20                  25                  30          
Leu Lys Glu Ala Phe
        35          


<210> 9
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Asp Lys Trp Lys Ala Val Tyr Asp Lys Phe Ala Glu Ala Phe Lys Glu
 1               5                  10                  15      
Phe Leu Pro Asp Lys Trp Lys Ala Val Tyr Asp Lys Phe Ala Glu Ala
            20                  25                  30          
Phe Lys Glu Phe Leu
        35          


<210> 10
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu
 1               5                  10                  15      
Ala Phe Pro Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys
            20                  25                  30          
Phe Lys Glu Ala Phe
        35          


<210> 11
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 11, 17
<223> Xaa = 2-aminoisobutyric acid

<400> 11
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Xaa Glu Lys Phe Lys Glu
 1               5                  10                  15      
Xaa Phe
        


<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 11, 17
<223> Xaa = 2-aminoisobutyric acid

<220> 
<221> ACETYLATION    
<222> 1

<220> 
<221> AMIDATION      
<222> 18

<400> 12
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Xaa Glu Lys Phe Lys Glu
 1               5                  10                  15      
Xaa Phe
        


<210> 13
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> ACETYLATION    
<222> 1

<220> 
<221> AMIDATION      
<222> 18

<400> 13
Asp Trp Phe Lys Ala Phe Tyr Asp Lys Val Ala Glu Lys Phe Lys Glu
 1               5                  10                  15      
Ala Phe
        


<210> 14
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = quinoline-2-carbonyl-Val (i.e., Val, where the 
N-terminus is quinoline-2-carbonyl)

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Asp(OMe)-2,6- difluorophenoxymethylketone (i.e., 
Asp, where the side-chain is methyl ester group, and
the C-terminus is 2,6-difluorophenoxymethylketone)

<400> 14
Xaa Xaa
 1      


<210> 15
<211> 1
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = tert-butyloxycarbonyl-Asp(OMe)-fluoromethylketone

<400> 15
Xaa
 1  


<210> 16
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Val

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Asp(OMe)-NH2

<400> 16
Xaa Ala Xaa
 1          


<210> 17
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Val

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 17
Xaa Ala Xaa
 1          


<210> 18
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Tyr

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 18
Xaa Val Ala Xaa
 1              


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Val

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Asp(OMe)

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 19
Xaa Xaa Val Ala Xaa
 1               5  


<210> 20
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = quinoline-2-carbonyl-Asp(OMe)

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-2,6-difluorophenoxymethylketone

<400> 20
Xaa Xaa Val Xaa
 1              


<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Asp(OMe)

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 21
Xaa Xaa Val Xaa
 1              


<210> 22
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Asp(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 22
Xaa Gln Met Xaa
 1              


<210> 23
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Leu

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 23
Xaa Xaa Val Xaa
 1              


<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Trp

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 24
Xaa Xaa His Xaa
 1              


<210> 25
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Val

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 25
Xaa Xaa Ile Xaa
 1              


<210> 26
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = quinoline-2-carbonyl-Ile

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-2,6-difluorophenoxymethylketone

<400> 26
Xaa Xaa Thr Xaa
 1              


<210> 27
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Ile

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 27
Xaa Xaa Thr Xaa
 1              


<210> 28
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = quinoline-2-carbonyl-Leu

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-2,6-difluorophenoxymethylketone

<400> 28
Xaa Xaa His Xaa
 1              


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Leu

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 29
Xaa Xaa His Xaa
 1              


<210> 30
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Ala

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 30
Xaa Xaa Val Xaa
 1              


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Ala

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 31
Xaa Thr Ala Xaa
 1              


<210> 32
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = benzyloxycarbonyl-Leu

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Glu(OMe)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asp(OMe)-fluoromethylketone

<400> 32
Xaa Xaa Xaa Xaa
 1              

