                         SEQUENCE LISTING

<110>  National Research Council of Canada
       Stanimirovic, Danica
       Chakravarthy, Balu
       Durocher, Yves
 
<120>  Blood-Brain Barrier Transmigrating Compounds and Uses Thereof

<130>  2016-028-04

<150>  62/452,015
<151>  2017-01-30

<150>  62/530,980
<151>  2017-07-11

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 FC5

<400>  1

Gly Phe Lys Ile Thr His Tyr Thr Met Gly 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 FC5

<400>  2

Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 FC5

<400>  3

Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr 
1               5                   10              


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 IGF1R-3

<400>  4

Glu Tyr Pro Ser Asn Phe Tyr Ala 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IGF1R-3

<400>  5

Val Ser Arg Asp Gly Leu Thr Thr 
1               5               


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 IGF1R-3

<400>  6

Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
1               5                   10                  15      


Ser Tyr His Tyr 
            20  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 IGF1R-4

<400>  7

Gly Gly Thr Val Ser Pro Thr Ala 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IGF1R-4

<400>  8

Ile Thr Trp Ser Arg Gly Thr Thr 
1               5               


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 IGF1R-4

<400>  9

Ala Ala Ser Thr Phe Leu Arg Ile Leu Pro Glu Glu Ser Ala Tyr Thr 
1               5                   10                  15      


Tyr 
    


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 IGF1R-5

<400>  10

Gly Arg Thr Ile Asp Asn Tyr Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 IGF1R-5


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  where X is A or T

<400>  11

Ile Asp Trp Gly Asp Gly Gly Xaa 
1               5               


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 IGF1R-5

<400>  12

Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  13
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized FC5 consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  where X is D or E

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  where X is A or E

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  where X is F or V

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  where X is E or G

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  where X is R or L

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  where X is F or W

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  where X is L or V

<400>  13

Xaa Val Gln Leu Val Xaa Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Xaa Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5

<400>  14

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H1

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H2

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  17
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  18
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-3 Consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  where X is E or Q

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  where X is K or Q

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  where X is V or E

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  where X is A or P

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  where X is V or A

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  where X is F or V

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  where X is E or G

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  where X is R or L

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  where X is F or W

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  where X is A or S

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  where X is M or I

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  where X is A or S

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  where X is V or L

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  where X is D or Y

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  where X is V or L

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  where X is K or R

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  where X is Q or L

<400>  18

Xaa Val Xaa Leu Xaa Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Xaa Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Xaa Ser Arg Asp Asn Xaa Lys Asn Thr Xaa Xaa 
65                  70                  75                  80  


Leu Gln Met Asn Ser Xaa Xaa Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 125         


<210>  19
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-3

<400>  19

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Val Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  20
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-3-H5

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Pro Ser Asn Phe Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Val Ser Arg Asp Gly Leu Thr Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Ile Thr Gly Val Trp Asn Lys Val Asp Val Asn Ser Arg 
            100                 105                 110         


Ser Tyr His Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  21
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-4 Consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  where X is E or Q

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  where X is K or Q

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  where X is V or E

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  where X is A or P

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  where X is A or E

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  where X is V or A

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  where X is V or F

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  where X is G or E

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  where X is L or R

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  where X is F or W

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  where X is G or S

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  where X is V or Y

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  where X is D or G

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  where X is N or S

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  where X is A or S

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  where X is L or V

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  where X is K or R

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  where X is A or S

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  where X is L or Q

<400>  21

Xaa Val Xaa Leu Xaa Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Xaa Xaa Ser Gly Gly Thr Val Ser Pro Thr 
            20                  25                  30          


Ala Met Gly Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Xaa His Ile Thr Trp Ser Arg Gly Thr Thr Arg Xaa Ala Ser Ser Val 
    50                  55                  60                  


Lys Xaa Arg Phe Thr Ile Ser Arg Asp Xaa Xaa Lys Asn Thr Xaa Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Phe Leu Arg Ile Leu Pro Glu Glu Ser Ala Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 


<210>  22
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-4

<400>  22

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Gly Thr Val Ser Pro Thr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly His Ile Thr Trp Ser Arg Gly Thr Thr Arg Val Ala Ser Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Phe Leu Arg Ile Leu Pro Glu Glu Ser Ala Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  23
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-4-H3

<400>  23

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Val Ser Pro Thr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Gly His Ile Thr Trp Ser Arg Gly Thr Thr Arg Tyr Ala Ser Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Thr Phe Leu Arg Ile Leu Pro Glu Glu Ser Ala Tyr Thr 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  24
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-5 Consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  where X is E or Q

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  where X is K or Q

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  where X is V or E

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  where X is A or P

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  where X is V or S

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  where X is D or G

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  where X is L or R

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  where X is F or W

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  where X is A or S

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  where X is A or T

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  where X is A or S

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  where X is G or N

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  where X is M or L

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  where X is N or R

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  where X is E or R

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  where X is P or A

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  where X is S or Y

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  where X is Q or L

<400>  24

Xaa Val Xaa Leu Xaa Glu Ser Gly Gly Gly Leu Val Gln Xaa Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Xaa Arg Gln Ala Pro Gly Lys Xaa Xaa Glu Xaa Val 
        35                  40                  45              


Xaa Thr Ile Asp Trp Gly Asp Gly Gly Xaa Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Xaa Lys Xaa Thr Xaa Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Xaa Leu Xaa Xaa Glu Asp Thr Ala Val Tyr Xaa Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120                 


<210>  25
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-5

<400>  25

Gln Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Ser Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Ala Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Gly Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  26
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R-5-H2

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  27
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PK-4

<400>  27

Ser Gly Lys Thr Glu Tyr Met Ala Phe Pro Lys Pro Phe Glu Ser Ser 
1               5                   10                  15      


Ser Ser Ile Gly Ala Glu Lys Pro Arg Asn Lys Lys Leu Pro Glu Glu 
            20                  25                  30          


Glu Val Glu Ser Ser Arg Thr Pro Trp Leu Tyr Glu Gln Glu Gly Glu 
        35                  40                  45              


Val Glu Lys Pro Phe Ile Lys Thr Gly Phe Ser Val Ser Val Glu Lys 
    50                  55                  60                  


Ser Thr Ser Ser Asn Arg Lys Asn Gln Leu Asp Thr Asn Gly Arg Arg 
65                  70                  75                  80  


Arg Gln Phe Asp Glu Glu Ser Leu Glu Ser Phe Ser Ser Met Pro Asp 
                85                  90                  95      


Pro Val Asp Pro Thr Thr Val Thr Lys Thr Phe Lys Thr Arg Lys Ala 
            100                 105                 110         


Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr Pro Lys Ser Lys 
        115                 120                 125             


Ser Lys Lys Arg Asn Ser Thr Gln Leu Lys Ser Arg Val Lys Asn Ile 
    130                 135                 140                 


Thr His Ala Arg Arg Ile Leu Gln Gln Ser Asn Arg Asn Ala Cys Asn 
145                 150                 155                 160 


Glu Ala Pro Glu Thr Gly Ser Asp Phe Ser Met Phe Glu Ala 
                165                 170                 


<210>  28
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P4 peptide

<400>  28

Phe Ser Ser Met Pro Asp Pro Val Asp Pro Thr Thr Val Thr Lys Thr 
1               5                   10                  15      


Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp 
            20                  25                  30          


Lys Thr Pro Lys Ser Lys Ser Lys 
        35                  40  


<210>  29
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P5 peptide

<400>  29

Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln 
1               5                   10                  15      


Leu Lys Ser Arg Val Lys Asn Ile Thr His Ala Arg Arg Ile Leu Gln 
            20                  25                  30          


Gln Ser Asn Arg Asn Ala Cys Asn 
        35                  40  


<210>  30
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P4-5 peptide (ABP)

<400>  30

Lys Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile 
        35                  40  


<210>  31
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABP consensus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  where X is G or A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  where X is G or V

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  where X is G or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  where X is G or A

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  where X is G or V

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  where X is G or V

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  where X is G or V

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  where X is G or A

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  where X is G or A

<400>  31

Xaa Thr Phe Xaa Thr Xaa Xaa Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Xaa Xaa Ser Thr Gln 
            20                  25                  30          


Leu Xaa Ser Xaa Val Xaa Asn Ile 
        35                  40  


<210>  32
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(G)]

<400>  32

Lys Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile 
        35                  40  


<210>  33
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(GG)]

<400>  33

Lys Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Gly Gly Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile 
        35                  40  


<210>  34
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(RG-G)]

<400>  34

Lys Thr Phe Lys Thr Arg Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile 
        35                  40  


<210>  35
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(GG-G)]

<400>  35

Lys Thr Phe Lys Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile 
        35                  40  


<210>  36
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(6G)]

<400>  36

Gly Thr Phe Gly Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Gly Gly Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile 
        35                  40  


<210>  37
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(GGspv)]

<400>  37

Lys Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Gly Gly Ser Thr Val 
            20                  25                  30          


Lys Asn Ile 
        35  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  [ABP(trc)]

<400>  38

Lys Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly 
            20                  25                  


<210>  39
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Fc2a

<400>  39

Ala Ser Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
1               5                   10                  15      


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            20                  25                  30          


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    50                  55                  60                  


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
65                  70                  75                  80  


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                85                  90                  95      


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            100                 105                 110         


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
        115                 120                 125             


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
    130                 135                 140                 


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
145                 150                 155                 160 


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
                165                 170                 175     


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
            180                 185                 190         


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
        195                 200                 205             


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
    210                 215                 220                 


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
225                 230                 


<210>  40
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Fc1x7

<400>  40

Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230         


<210>  41
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Fc1X0

<400>  41

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Gly Pro Glu Val Lys Phe Asn Trp His 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Gly Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230         


<210>  42
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-mFc2a-ABP

<400>  42

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ser Glu Pro Arg Gly 
        115                 120                 125             


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
145                 150                 155                 160 


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
            180                 185                 190         


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
        195                 200                 205             


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
    210                 215                 220                 


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
                245                 250                 255     


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
            260                 265                 270         


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
        275                 280                 285             


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
    290                 295                 300                 


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
305                 310                 315                 320 


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
                325                 330                 335     


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
            340                 345                 350         


Arg Thr Pro Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys 
        355                 360                 365             


Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys 
    370                 375                 380                 


Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu 
385                 390                 395                 400 


Lys Ser Arg Val Lys Asn Ile 
                405         


<210>  43
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-mFc2a-ABP

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Glu Pro Arg Gly 
        115                 120                 125             


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
145                 150                 155                 160 


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
            180                 185                 190         


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
        195                 200                 205             


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
    210                 215                 220                 


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
                245                 250                 255     


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
            260                 265                 270         


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
        275                 280                 285             


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
    290                 295                 300                 


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
305                 310                 315                 320 


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
                325                 330                 335     


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
            340                 345                 350         


Arg Thr Pro Gly Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys 
        355                 360                 365             


Thr Phe Lys Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys 
    370                 375                 380                 


Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu 
385                 390                 395                 400 


Lys Ser Arg Val Lys Asn Ile 
                405         


<210>  44
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-hFc1X7-ABP

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Thr Phe Lys 
        355                 360                 365             


Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr 
    370                 375                 380                 


Pro Lys Ser Lys Ser Lys Lys Arg Asn Ser Thr Gln Leu Lys Ser Arg 
385                 390                 395                 400 


Val Lys Asn Ile 
                


<210>  45
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-hFc1X7-ABP(G)

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Thr Phe Lys 
        355                 360                 365             


Thr Arg Lys Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr 
    370                 375                 380                 


Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln Leu Lys Ser Arg 
385                 390                 395                 400 


Val Lys Asn Ile 
                


<210>  46
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-hFc1X7-ABP(GG-G)

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Thr Phe Lys 
        355                 360                 365             


Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr 
    370                 375                 380                 


Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln Leu Lys Ser Arg 
385                 390                 395                 400 


Val Lys Asn Ile 
                


<210>  47
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-hFc1X7-ABP(6G)

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Phe Gly 
        355                 360                 365             


Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr 
    370                 375                 380                 


Pro Lys Ser Lys Ser Lys Lys Gly Gly Ser Thr Gln Leu Lys Ser Arg 
385                 390                 395                 400 


Val Lys Asn Ile 
                


<210>  48
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5(H3)-ABP(GG-G)- hFc1X7

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Lys Thr Phe Lys Thr Gly Gly Ala Ser Ala Gln Ala 
    130                 135                 140                 


Ser Leu Ala Ser Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg 
145                 150                 155                 160 


Gly Ser Thr Gln Leu Lys Ser Arg Val Lys Asn Ile Gly Gly Gly Gly 
                165                 170                 175     


Ser Gly Gly Gly Gly Ser Ala Glu Pro Lys Ser Ser Asp Lys Thr His 
            180                 185                 190         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        195                 200                 205             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    210                 215                 220                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Gly Pro Glu 
225                 230                 235                 240 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                245                 250                 255     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            260                 265                 270         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        275                 280                 285             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    290                 295                 300                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
305                 310                 315                 320 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                325                 330                 335     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            340                 345                 350         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        355                 360                 365             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    370                 375                 380                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
385                 390                 395                 400 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                405                 410                 


<210>  49
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-hFc1X0-ABP(GG-G)

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys Ser Cys 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Gly Pro Glu Val Lys Phe Asn Trp His Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Gly Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Thr Phe Lys 
        355                 360                 365             


Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr 
    370                 375                 380                 


Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln Leu Lys Ser Arg 
385                 390                 395                 400 


Val Lys Asn Ile 
                


<210>  50
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IGF1R5-H2-hFc1X7-ABP(GG-G)

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp Asn Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys 
        115                 120                 125             


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    130                 135                 140                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
145                 150                 155                 160 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                165                 170                 175     


Ser His Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            180                 185                 190         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        195                 200                 205             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    210                 215                 220                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
225                 230                 235                 240 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                245                 250                 255     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
            260                 265                 270         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        275                 280                 285             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    290                 295                 300                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
305                 310                 315                 320 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                325                 330                 335     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            340                 345                 350         


Leu Ser Pro Gly Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Thr 
        355                 360                 365             


Phe Lys Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp 
    370                 375                 380                 


Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln Leu Lys 
385                 390                 395                 400 


Ser Arg Val Lys Asn Ile 
                405     


<210>  51
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABP(GG-G)-hFc1X7- IGF1R5-H2

<400>  51

Lys Thr Phe Lys Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser 
1               5                   10                  15      


Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr Gln 
            20                  25                  30          


Leu Lys Ser Arg Val Lys Asn Ile Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              


Ser Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser His Glu Gly Pro Glu Val Lys Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            180                 185                 190         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Val Gln Leu Val Glu Ser 
        275                 280                 285             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
    290                 295                 300                 


Ala Ser Gly Arg Thr Ile Asp Asn Tyr Ala Met Ala Trp Val Arg Gln 
305                 310                 315                 320 


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Asp Trp Gly Asp 
                325                 330                 335     


Gly Gly Thr Arg Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser 
            340                 345                 350         


Arg Asp Asn Ser Lys Asn Thr Met Tyr Leu Gln Met Asn Ser Leu Arg 
        355                 360                 365             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Met Ala Arg Gln Ser Arg 
    370                 375                 380                 


Val Asn Leu Asp Val Ala Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu 
385                 390                 395                 400 


Val Thr Val Ser Ser 
                405 


<210>  52
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hFc1X7- ABP(GG-G)- IGF1R5-H2

<400>  52

Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Lys Thr Phe Lys Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala 
                245                 250                 255     


Ser Lys Asp Lys Thr Pro Lys Ser Lys Ser Lys Lys Arg Gly Ser Thr 
            260                 265                 270         


Gln Leu Lys Ser Arg Val Lys Asn Ile Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    290                 295                 300                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Asp 
305                 310                 315                 320 


Asn Tyr Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                325                 330                 335     


Trp Val Ala Thr Ile Asp Trp Gly Asp Gly Gly Thr Arg Tyr Ala Asn 
            340                 345                 350         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        355                 360                 365             


Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Ala Met Ala Arg Gln Ser Arg Val Asn Leu Asp Val Ala Arg 
385                 390                 395                 400 


Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 


<210>  53
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5-H3-hFc1X7-L(consensus)-ABP(6G)


<220>
<221>  misc_feature
<222>  (356)..(356)
<223>  where X is A or G

<220>
<221>  misc_feature
<222>  (358)..(358)
<223>  where X is A or G

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  where X is S or T

<220>
<221>  misc_feature
<222>  (361)..(361)
<223>  where X is G or V

<220>
<221>  misc_feature
<222>  (362)..(362)
<223>  where X is A or V

<220>
<221>  misc_feature
<222>  (364)..(364)
<223>  where X is S or T

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Glu Pro Lys Ser Ser 
        115                 120                 125             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    130                 135                 140                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
145                 150                 155                 160 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                165                 170                 175     


Glu Gly Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            180                 185                 190         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        195                 200                 205             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    210                 215                 220                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
225                 230                 235                 240 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                245                 250                 255     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            260                 265                 270         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        275                 280                 285             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    290                 295                 300                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
305                 310                 315                 320 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                325                 330                 335     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            340                 345                 350         


Pro Gly Thr Xaa Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Gly Thr Phe Gly 
        355                 360                 365             


Thr Gly Gly Ala Ser Ala Gln Ala Ser Leu Ala Ser Lys Asp Lys Thr 
    370                 375                 380                 


Pro Lys Ser Lys Ser Lys Lys Gly Gly Ser Thr Gln Leu Lys Ser Arg 
385                 390                 395                 400 


Val Lys Asn Ile 
                


