                         SEQUENCE LISTING

<110>  National Research Council of Canada
 
<120>  Hemagglutinin-Specific Antibodies and Uses Thereof

<130>  5659-60

<150>  US 62/451,230
<151>  2017-01-27

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L1 sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein X is R or D

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X is N or T

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Wherein X is H or F

<400>  1

Gln Ser Leu Leu Asn Ser Xaa Xaa Gln Lys Asn Xaa 
1               5                   10          


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L3 sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Wherein X is T or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is Y or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein X is P or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Wherein X is R or L

<400>  2

Gln Gln Tyr Tyr Xaa Xaa Xaa Xaa Thr 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H1 sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Wherein X is S or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X is I or F

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is S or no amino acid

<400>  3

Gly Tyr Xaa Xaa Thr Xaa Asp Tyr Tyr 
1               5                   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H2 sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Wherein X is S or T

<400>  4

Ile Gly Tyr Asp Gly Xaa Lys 
1               5           


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H2 sequence

<400>  5

Ile Tyr Pro Gly Asn Gly His Thr 
1               5               


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H3 sequence

<400>  6

Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp Tyr 
1               5                   10              


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H3 sequence

<400>  7

Ala Tyr Asp Leu Phe Asn Tyr 
1               5           


<210>  8
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L1 sequence

<400>  8

Gln Ser Leu Leu Asn Ser Arg Asn Gln Lys Asn His 
1               5                   10          


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L1 sequence

<400>  9

Gln Ser Leu Leu Asn Ser Asp Thr Gln Lys Asn Phe 
1               5                   10          


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L3 sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Wherein X is P or no amino acid

<400>  10

Gln Gln Tyr Tyr Thr Tyr Xaa Arg Thr 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L3 sequence

<400>  11

Gln Gln Tyr Tyr Ser Ile Pro Leu Thr 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H1 sequence

<400>  12

Gly Tyr Ser Ile Thr Ser Asp Tyr Tyr 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H1 sequence

<400>  13

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) L3 sequence

<400>  14

Gln Gln Tyr Tyr Thr Tyr Arg Thr 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H2 sequence

<400>  15

Ile Gly Tyr Asp Gly Ser Lys 
1               5           


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR) H2 sequence

<400>  16

Ile Gly Tyr Asp Gly Thr Lys 
1               5           


<210>  17
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from variable light domain (VL)


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Wherein X is S or T

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Wherein X is V or M

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Wherein X is E or O

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Wherein X is R or D

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Wherein X is N or T

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Wherein X is H or F

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Wherein X is L or I

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Wherein X is I or V

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Wherein X is W or F

<220>
<221>  MISC_FEATURE
<222>  (60)..(60)
<223>  Wherein X is R or K

<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Wherein X is S or I

<220>
<221>  MISC_FEATURE
<222>  (71)..(71)
<223>  Wherein X is D or S

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Wherein X is S or T

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Wherein X is K or Q

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Wherein X is V or D

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Wherein X is Y or F

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Wherein X is T or S

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Wherein X is Y or I

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Wherein X is P or no amino acid

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Wherein X is R or L

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Wherein X is G or A

<400>  17

Asp Ile Val Met Xaa Gln Ser Pro Ser Ser Leu Ala Xaa Ser Val Gly 
1               5                   10                  15      


Xaa Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Xaa Xaa Gln Lys Asn Xaa Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Xaa Leu Xaa Tyr Xaa Ala Ser Thr Xaa Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Xaa Gly Xaa Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Xaa Ser Val Xaa Ala Glu Asp Leu Ala Xaa Tyr Xaa Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Xaa Xaa Xaa Xaa Thr Phe Gly Xaa Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from variable light domain (VL)


<220>
<221>  MISC_FEATURE
<222>  (69)..(69)
<223>  Wherein X is S or T

<400>  18

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Xaa Gly Asp Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from variable light domain (VL)

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Asp Thr Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Ile Leu Val Tyr Phe Ala Ser Thr Lys Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  20
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from variable heavy domain (VH)


<220>
<221>  MISC_FEATURE
<222>  (57)..(57)
<223>  Wherein X is S or T

<400>  20

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Gly Tyr Asp Gly Xaa Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  21
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from variable heavy domain (VH)

<400>  21

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Pro Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Gly His Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Val Arg Ala Thr Leu Thr Ala Asp Asn Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Tyr Asp Leu Phe Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of variable light domain (VL)

<400>  22

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Asp Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of variable light domain (VL)

<400>  23

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Asn Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Asp Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Thr Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of variable heavy domain (VH)

<400>  24

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Gly Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence of variable heavy domain (VH)

<400>  25

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Gly Tyr Asp Gly Thr Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody, or fragment thereof, binding peptide

<400>  26

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
1               5                   10                  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  27

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide

<400>  28

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  29
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from mAbs

<400>  29

Arg Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly 
1               5                   10                  15      


Phe Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys 
    50                  55                  60                  


Leu Glu Trp Met Ala Tyr Ile Gly Tyr Asp Gly Thr Lys Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  30
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from mAbs

<400>  30

Val Leu Met Leu Leu Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile 
1               5                   10                  15      


Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys 
            20                  25                  30          


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Asn 
        35                  40                  45              


Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Asp Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Thr Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  31
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from mAbs

<400>  31

Ala Gly Val His Cys Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu 
1               5                   10                  15      


Val Lys Pro Gly Ala Pro Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
            20                  25                  30          


Thr Phe Thr Asp Tyr Tyr Ile His Trp Val Asn Gln Arg Pro Gly Gln 
        35                  40                  45              


Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Gly Asn Gly His Thr Val 
    50                  55                  60                  


Tyr Asn Gln Lys Phe Lys Val Arg Ala Thr Leu Thr Ala Asp Asn Pro 
65                  70                  75                  80  


Ser Ser Thr Ala Tyr Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser 
                85                  90                  95      


Gly Val Tyr Phe Cys Ala Tyr Asp Leu Phe Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
    210                 215                 220                 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
                245                 250                 255     


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
            260                 265                 270         


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
    290                 295                 300                 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
        355                 360                 365             


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
    370                 375                 380                 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
                405                 410                 415     


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        435                 440                 445             


Lys 
    


<210>  32
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from mAbs

<400>  32

Val Ser Gly Ala Cys Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser 
1               5                   10                  15      


Leu Ala Met Ser Val Gly Gln Lys Val Thr Met Ser Cys Lys Ser Ser 
            20                  25                  30          


Gln Ser Leu Leu Asn Ser Asp Thr Gln Lys Asn Phe Leu Ala Trp Tyr 
        35                  40                  45              


Gln Gln Lys Pro Gly Gln Ser Pro Lys Ile Leu Val Tyr Phe Ala Ser 
    50                  55                  60                  


Thr Lys Glu Ser Gly Val Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly 
65                  70                  75                  80  


Thr Asp Phe Thr Leu Thr Ile Thr Ser Val Gln Ala Glu Asp Leu Ala 
                85                  90                  95      


Asp Tyr Phe Cys Gln Gln Tyr Tyr Ser Ile Pro Leu Thr Phe Gly Ala 
            100                 105                 110         


Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120                 125             


Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val 
    130                 135                 140                 


Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp 
145                 150                 155                 160 


Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr 
                165                 170                 175     


Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr 
            180                 185                 190         


Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala 
        195                 200                 205             


Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn 
    210                 215                 220                 


Glu Cys 
225     


<210>  33
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from mAbs

<400>  33

Arg Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly 
1               5                   10                  15      


Phe Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys 
    50                  55                  60                  


Leu Glu Trp Met Ala Tyr Ile Gly Tyr Asp Gly Ser Lys Asn Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Ala 
    130                 135                 140                 


Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser 
145                 150                 155                 160 


Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr 
        195                 200                 205             


Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala 
    210                 215                 220                 


His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly 
225                 230                 235                 240 


Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val 
            260                 265                 270         


Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val 
    290                 295                 300                 


Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser 
305                 310                 315                 320 


Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met 
                325                 330                 335     


Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro 
        355                 360                 365             


Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln 
    370                 375                 380                 


Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr 
385                 390                 395                 400 


Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr 
                405                 410                 415     


Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
            420                 425                 430         


Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser 
        435                 440                 445             


Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser 
    450                 455                 460                 


Arg Thr Pro Gly Lys 
465                 


<210>  34
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence from mAbs

<400>  34

Val Leu Met Leu Leu Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile 
1               5                   10                  15      


Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Glu Lys 
            20                  25                  30          


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Asn 
        35                  40                  45              


Gln Lys Asn His Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Asp Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Thr Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  35
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 10A9 sequence

<400>  35

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Pro Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Tyr Ile His Trp Val Asn Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Tyr Pro Gly Asn Gly His Thr Val Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Val Arg Ala Thr Leu Thr Ala Asp Asn Pro Ser 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Gly 
            100                 105                 110         


Val Tyr Phe Cys Ala Tyr Asp Leu Phe Asn Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
225                 230                 235                 240 


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
            260                 265                 270         


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
        275                 280                 285             


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
    290                 295                 300                 


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
305                 310                 315                 320 


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
                325                 330                 335     


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
            340                 345                 350         


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
        355                 360                 365             


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
    370                 375                 380                 


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
385                 390                 395                 400 


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
            420                 425                 430         


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
        435                 440                 445             


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
465                 470                 475                 480 


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Glu Thr Asp Thr 
                485                 490                 495     


Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Asp 
            500                 505                 510         


Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly Gln 
        515                 520                 525             


Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Asp 
    530                 535                 540                 


Thr Gln Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Ile Leu Val Tyr Phe Ala Ser Thr Lys Glu Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            580                 585                 590         


Thr Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr 
        595                 600                 605             


Tyr Ser Ile Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
    610                 615                 620                 


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
625                 630                 635                 640 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
            660                 665                 670         


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
    690                 695                 700                 


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
705                 710                 715                 720 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
                725                 730     


<210>  36
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb 11H12 sequence

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser 
        35                  40                  45              


Ile Thr Ser Asp Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn 
    50                  55                  60                  


Lys Leu Glu Trp Met Ala Tyr Ile Gly Tyr Asp Gly Thr Lys Asn Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Asp Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Thr Arg Asp Arg Ala Asn Trp Asp Asp Tyr Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
            260                 265                 270         


Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
    290                 295                 300                 


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
305                 310                 315                 320 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
                325                 330                 335     


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
        355                 360                 365             


Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
    370                 375                 380                 


Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
385                 390                 395                 400 


Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
                405                 410                 415     


Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
            420                 425                 430         


Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
        435                 440                 445             


Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
    450                 455                 460                 


Ser Arg Thr Pro Gly Arg Lys Arg Arg Ala Pro Val Lys Gln Thr Leu 
465                 470                 475                 480 


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
                485                 490                 495     


Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val 
            500                 505                 510         


Pro Gly Ser Thr Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu 
        515                 520                 525             


Ala Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln 
    530                 535                 540                 


Ser Leu Leu Asn Ser Arg Asn Gln Lys Asn His Leu Ala Trp Tyr Gln 
545                 550                 555                 560 


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr 
                565                 570                 575     


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Asp Gly Ser Gly Thr 
            580                 585                 590         


Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val 
        595                 600                 605             


Tyr Tyr Cys Gln Gln Tyr Tyr Thr Tyr Arg Thr Phe Gly Gly Gly Thr 
    610                 615                 620                 


Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
625                 630                 635                 640 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
                645                 650                 655     


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
            660                 665                 670         


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
        675                 680                 685             


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
    690                 695                 700                 


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
705                 710                 715                 720 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
                725                 730                 735     


