﻿               SEQUENCE LISTING

<110> Istituti Clinici Scientifici Maugeri SpA - Società Benefit

<120> BIOLOGICALLY ACTIVE FUSION PEPTIDE FOR USE IN THE TREATMENT OF SPINAL MUSCULAR ATROPHY (SMA)

<130> PCT 107970

<150> IT102017000008082
<151> 2017-01-25

<160> 33

<170> BiSSAP 1.3.6

<210> 1
<211> 10
<212> PRT
<213> HIV-1 


<400> 1
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  

<210> 2
<211> 13
<212> PRT
<213> HIV-1 


<400> 2
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              

<210> 3
<211> 9
<212> PRT
<213> HIV-1 


<400> 3
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   

<210> 4
<211> 11
<212> PRT
<213> HIV-1 


<400> 4
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      

<210> 5
<211> 10
<212> PRT
<213> HIV-1 


<400> 5
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg 
1               5                   10  

<210> 6
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Optimized version of TAT47-57

<400> 6
Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      

<210> 7
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 7
Arg Arg Arg Arg Arg 
1               5   

<210> 8
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 8
Arg Arg Arg Arg Arg Arg 
1               5       

<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 9
Arg Arg Arg Arg Arg Arg Arg 
1               5           

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 10
Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               

<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 11
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   

<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 12
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 13
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10      

<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 14
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          

<210> 15
<211> 16
<212> PRT
<213> Drosophila melanogaster 


<220> 
<223> Peptide from Antennapedia homeodomain

<400> 15
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      



<210> 16
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 16
Val Lys Arg Gly Leu Lys Leu Arg His Val Arg Pro Arg Val Thr Arg 
1               5                   10                  15      
Met Asp Val 
            

<210> 17
<211> 18
<212> PRT
<213> Mus musculus


<220> 
<223> Peptide from murine vascular endothelial cadherin

<400> 17
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      
Ser Lys 
        

<210> 18
<211> 22
<212> PRT
<213> Homo sapiens


<220> 
<223> Peptide from human p14ARF protein

<400> 18
Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      
Pro Pro Arg Val Arg Val 
            20          

<210> 19
<211> 28
<212> PRT
<213> Bos taurus


<220> 
<223> Peptide from N-terminus of unprocessed bovine prion protein

<400> 19
Met Val Lys Ser Lys Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala 
1               5                   10                  15      
Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro 
            20                  25              

<210> 20
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 20
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      
Leu Ala 
        

<210> 21
<211> 27
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide corresponding to chimeric galanin-mastoparan (mastoparan
      is from wasp (Vespula lewisii) venom)

<400> 21
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      
Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          

<210> 22
<211> 28
<212> PRT
<213> Pseudomonas aeruginosa


<220> 
<223> Peptide from bacterial azurin

<400> 22
Leu Ser Thr Ala Ala Asp Met Gln Gly Val Val Thr Asp Gly Met Ala 
1               5                   10                  15      
Ser Gly Leu Asp Lys Asp Tyr Leu Lys Pro Asp Asp 
            20                  25              

<210> 23
<211> 26
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide

<400> 23
Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      
Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      

<210> 24
<211> 24
<212> PRT
<213> Bos taurus


<220> 
<223> Peptide from Bactenecin family of antimicrobial peptides from
      bovine neutrophils

<400> 24
Arg Arg Ile Arg Pro Arg Pro Pro Arg Leu Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      
Pro Leu Pro Phe Pro Arg Pro Gly 
            20                  

<210> 25
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide based on the amino acid sequence of Human alpha
      1-Antitrypsin

<400> 25
Cys Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Tyr Leu 
1               5                   10                  15      
Ile 
    

<210> 26
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide corresponding to a minimal active sequence of C105Y

<400> 26
Pro Phe Val Tyr Leu Ile 
1               5       

<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptide from CHL8 peptide phage clone

<400> 27
Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  

<210> 28
<211> 294
<212> PRT
<213> Homo sapiens


<220> 
<223> full-length human SMN protein

<400> 28
Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      
Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          
Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              
Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  
Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  
Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      
Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         
Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             
Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 
Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 
Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     
Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         
Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             
Lys Pro Gly Leu Lys Phe Asn Gly Pro Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 
Pro Pro His Leu Leu Ser Cys Trp Leu Pro Pro Phe Pro Ser Gly Pro 
225                 230                 235                 240 
Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
                245                 250                 255     
Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
            260                 265                 270         
His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
        275                 280                 285             
Cys Ser His Ser Leu Asn 
    290                 

<210> 29
<211> 60
<212> PRT
<213> Homo sapiens


<220> 
<223> Fragment of the full-length human SMN protein, i.e. the
      SMN235-294 carboxy-terminal domain

<400> 29
Pro Phe Pro Ser Gly Pro Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys 
1               5                   10                  15      
Pro Asp Ser Leu Asp Asp Ala Asp Ala Leu Gly Ser Met Leu Ile Ser 
            20                  25                  30          
Trp Tyr Met Ser Gly Tyr His Thr Gly Tyr Tyr Met Gly Phe Arg Gln 
        35                  40                  45              
Asn Gln Lys Glu Gly Arg Cys Ser His Ser Leu Asn 
    50                  55                  60  

<210> 30
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 30
ccagaagaaa acctgccaag aa                                             22


<210> 31
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 31
cacttgtcac caactttcca ctgt                                           24


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 32
tgaatcacgt ttgtgtcatt a                                              21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 33
ttcaacttgc gctcatctta g                                              21


