                         SEQUENCE LISTING

<110>  Medimmune LLC
       Medimmune Ltd
 
<120>  Relaxin fusion polypeptides and uses thereof

<130>  RLX2-100-US-PCT

<150>  US 62/450,338
<151>  2017-01-25

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  1
gataaaaccc atacctgccc gccgtgcccg gcgccggaac tgctgggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcagc ccgcagctgt atagcgcgct ggcgaacaaa      720

tgctgccatg tgggctgcac caaacgcagc ctggcgcgct tttgcggcgg cggcggcagc      780

ggcggcggcg gcagcggcgg cggcggcagc agctggatgg aagaagtgat taaactgtgt      840

ggccgcgaac tggtgcgcgc gcagattgcg atttgcggca tgagcacctg gagctga         897


<210>  2
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  2

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala Asn Lys 
225                 230                 235                 240 


Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp 
            260                 265                 270         


Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln 
        275                 280                 285             


Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295             


<210>  3
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  3
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttgaaggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg agcattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcagc ccgcagctgt atagcgcgct ggcgaacaaa      720

tgctgccatg tgggctgcac caaacgcagc ctggcgcgct tttgcggcgg cggcggcagc      780

ggcggcggcg gcagcggcgg cggcggcagc agctggatgg aagaagtgat taaactgtgt      840

ggccgcgaac tggtgcgcgc gcagattgcg atttgcggca tgagcacctg gagctga         897


<210>  4
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala Asn Lys 
225                 230                 235                 240 


Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp 
            260                 265                 270         


Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln 
        275                 280                 285             


Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295             


<210>  5
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  5
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttcagggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgccaggtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcagc ccgcagctgt atagcgcgct ggcgaacaaa      720

tgctgccatg tgggctgcac caaacgcagc ctggcgcgct tttgcggcgg cggcggcagc      780

ggcggcggcg gcagcggcgg cggcggcagc agctggatgg aagaagtgat taaactgtgt      840

ggccgcgaac tggtgcgcgc gcagattgcg atttgcggca tgagcacctg gagctga         897


<210>  6
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Gln Gln 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala Asn 
225                 230                 235                 240 


Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
            260                 265                 270         


Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala 
        275                 280                 285             


Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295                 


<210>  7
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  7
gataaaaccc atacctgccc gccgtgcccg gcgccggaac tgctgggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcagc ccgcagctgt atagcgcgct ggcgaacaaa      720

tgctgccatg tgggctgcac caaacgcagc ctggcgcgct tttgcggcgg cggcggcagc      780

ggcggcggcg gcagcggcgg cggcggcagc agctggatgg aagaagtgat taaactgtgt      840

ggccgcgaac tggtgcgcgc gcagattgcg atttgcggca tgagcacctg gagctgataa      900


<210>  8
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala Asn Lys 
225                 230                 235                 240 


Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp 
            260                 265                 270         


Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln 
        275                 280                 285             


Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295             


<210>  9
<211>  897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  9
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttgaaggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg agcattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcagc ccgcagctgt atagcgcgct ggcgaacaaa      720

tgctgccatg tgggctgcac caaacgcagc ctggcgcgct tttgcggcgg cggcggcagc      780

ggcggcggcg gcagcggcgg cggcggcagc agctggatgg aagaagtgat taaactgtgt      840

ggccgcgaac tggtgcgcgc gcagattgcg atttgcggca tgagcacctg gagctga         897


<210>  10
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  10

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala Asn Lys 
225                 230                 235                 240 


Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp 
            260                 265                 270         


Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln 
        275                 280                 285             


Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295             


<210>  11
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  11
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttcagggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgccaggtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcagc ccgcagctgt atagcgcgct ggcgaacaaa      720

tgctgccatg tgggctgcac caaacgcagc ctggcgcgct tttgcggcgg cggcggcagc      780

ggcggcggcg gcagcggcgg cggcggcagc agctggatgg aagaagtgat taaactgtgt      840

ggccgcgaac tggtgcgcgc gcagattgcg atttgcggca tgagcacctg gagctgataa      900


<210>  12
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein

<400>  12

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Gln Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala Asn Lys 
225                 230                 235                 240 


Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp 
            260                 265                 270         


Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln 
        275                 280                 285             


Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295             


<210>  13
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  13
gaatctaagt acggccctcc ctgcccaccc tgccctgccc ctgaatttct gggcggaccc       60

tccgtgttcc tgttcccacc caagcccaag gacaccctga tgatcagccg gacccctgaa      120

gtgacctgcg tggtggtgga cgtgtcccag gaagatcccg aggtccagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag      300

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgagaaaac catcagcaag      360

gccaagggcc agccccgcga gccccaggtc tacacactgc ctcccagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctaccccag cgatatcgcc      480

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc tcccgtgctg      540

gacagcgacg gcagcttctt tctgtactcc cggctgaccg tggacaagag ccggtggcag      600

gaaggcaacg tcttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctga gcctgagcct gggcaagggc ggcagcccgc agctgtatag cgcgctggcg      720

aacaaatgct gccatgtggg ctgcaccaaa cgcagcctgg cgcgcttttg cggcggcggc      780

ggcagcggcg gcggcggcag cggcggcggc ggcagcagct ggatggaaga agtgattaaa      840

ctgtgtggcc gcgaactggt gcgcgcgcag attgcgattt gcggcatgag cacctggagc      900

tga                                                                    903


<210>  14
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  14

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Gly Gly Ser Pro Gln Leu Tyr Ser Ala Leu Ala 
225                 230                 235                 240 


Asn Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe 
                245                 250                 255     


Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
        275                 280                 285             


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
    290                 295                 300 


<210>  15
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  15
gataaaaccc atacctgccc gccgtgcccg gcgccggaac tgctgggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcggc      720

ggcagccagc tgtatagcgc gctggcgaac aaatgctgcc atgtgggctg caccaaacgc      780

agcctggcgc gcttttgcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      840

agcagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt      900

gcgatttgcg gcatgagcac ctggagctga                                       930


<210>  16
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  16

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly 
                245                 250                 255     


Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile 
        275                 280                 285             


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
    290                 295                 300                 


Met Ser Thr Trp Ser 
305                 


<210>  17
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  17
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttgaaggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg agcattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcggc      720

ggcagccagc tgtatagcgc gctggcgaac aaatgctgcc atgtgggctg caccaaacgc      780

agcctggcgc gcttttgcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      840

agcagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt      900

gcgatttgcg gcatgagcac ctggagctga                                       930


<210>  18
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  18

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly 
                245                 250                 255     


Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile 
        275                 280                 285             


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
    290                 295                 300                 


Met Ser Thr Trp Ser 
305                 


<210>  19
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  19
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttcagggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgccaggtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcggc      720

ggcagccagc tgtatagcgc gctggcgaac aaatgctgcc atgtgggctg caccaaacgc      780

agcctggcgc gcttttgcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      840

agcagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt      900

gcgatttgcg gcatgagcac ctggagctga                                       930


<210>  20
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  20

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Gln Gln 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val 
                245                 250                 255     


Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val 
        275                 280                 285             


Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys 
    290                 295                 300                 


Gly Met Ser Thr Trp Ser 
305                 310 


<210>  21
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  21
gataaaaccc atacctgccc gccgtgcccg gcgccggaac tgctgggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcggc      720

ggcagccagc tgtatagcgc gctggcgaac aaatgctgcc atgtgggctg caccaaacgc      780

agcctggcgc gcttttgcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      840

agcagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt      900

gcgatttgcg gcatgagcac ctggagctga taa                                   933


<210>  22
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  22

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly 
                245                 250                 255     


Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile 
        275                 280                 285             


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
    290                 295                 300                 


Met Ser Thr Trp Ser 
305                 


<210>  23
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  23
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttgaaggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg agcattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcggc      720

ggcagccagc tgtatagcgc gctggcgaac aaatgctgcc atgtgggctg caccaaacgc      780

agcctggcgc gcttttgcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      840

agcagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt      900

gcgatttgcg gcatgagcac ctggagctga                                       930


<210>  24
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  24

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly 
                245                 250                 255     


Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile 
        275                 280                 285             


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
    290                 295                 300                 


Met Ser Thr Trp Ser 
305                 


<210>  25
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  25
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttcagggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgccaggtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa aggcggcggc ggcagcggcg gcggcggcag cggcggcggc      720

ggcagccagc tgtatagcgc gctggcgaac aaatgctgcc atgtgggctg caccaaacgc      780

agcctggcgc gcttttgcgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      840

agcagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt      900

gcgatttgcg gcatgagcac ctggagctga taa                                   933


<210>  26
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  26

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Gln Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly 
                245                 250                 255     


Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile 
        275                 280                 285             


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
    290                 295                 300                 


Met Ser Thr Trp Ser 
305                 


<210>  27
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  27
gaatctaagt acggccctcc ctgcccaccc tgccctgccc ctgaatttct gggcggaccc       60

tccgtgttcc tgttcccacc caagcccaag gacaccctga tgatcagccg gacccctgaa      120

gtgacctgcg tggtggtgga cgtgtcccag gaagatcccg aggtccagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag      300

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgagaaaac catcagcaag      360

gccaagggcc agccccgcga gccccaggtc tacacactgc ctcccagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctaccccag cgatatcgcc      480

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc tcccgtgctg      540

gacagcgacg gcagcttctt tctgtactcc cggctgaccg tggacaagag ccggtggcag      600

gaaggcaacg tcttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctga gcctgagcct gggcaagggc ggcggcggca gcggcggcgg cggcagcggc      720

ggcggcggca gccagctgta tagcgcgctg gcgaacaaat gctgccatgt gggctgcacc      780

aaacgcagcc tggcgcgctt ttgcggcggc ggcggcagcg gcggcggcgg cagcggcggc      840

ggcggcagca gctggatgga agaagtgatt aaactgtgtg gccgcgaact ggtgcgcgcg      900

cagattgcga tttgcggcat gagcacctgg agctga                                936


<210>  28
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  28

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His 
                245                 250                 255     


Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu 
        275                 280                 285             


Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile 
    290                 295                 300                 


Cys Gly Met Ser Thr Trp Ser 
305                 310     


<210>  29
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-TM

<400>  29
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttgaaggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg agcattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa a                                                681


<210>  30
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-TM

<400>  30

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  31
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-FQQ

<400>  31
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttcagggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgatgatta gccgcacccc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgccaggtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa a                                                681


<210>  32
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-FQQ

<400>  32

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Gln Gln 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  33
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-YTE

<400>  33
gataaaaccc atacctgccc gccgtgcccg gcgccggaac tgctgggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa a                                                681


<210>  34
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-YTE

<400>  34

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  35
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-YTE-TM

<400>  35
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttgaaggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgcaaagtga gcaacaaagc gctgccggcg agcattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa a                                                681


<210>  36
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-YTE-TM

<400>  36

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  37
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-YTE-FQQ

<400>  37
gataaaaccc atacctgccc gccgtgcccg gcgccggaat ttcagggcgg cccgagcgtg       60

tttctgtttc cgccgaaacc gaaagatacc ctgtatatta cccgcgaacc ggaagtgacc      120

tgcgtggtgg tggatgtgag ccatgaagat ccggaagtga aatttaactg gtatgtggat      180

ggcgtggaag tgcataacgc gaaaaccaaa ccgcgcgaag aacagtataa cagcacctat      240

cgcgtggtga gcgtgctgac cgtgctgcat caggattggc tgaacggcaa agaatataaa      300

tgccaggtga gcaacaaagc gctgccggcg ccgattgaaa aaaccattag caaagcgaaa      360

ggccagccgc gcgaaccgca ggtgtatacc ctgccgccga gccgcgatga actgaccaaa      420

aaccaggtga gcctgacctg cctggtgaaa ggcttttatc cgagcgatat tgcggtggaa      480

tgggaaagca acggccagcc ggaaaacaac tataaaacca ccccgccggt gctggatagc      540

gatggcagct tttttctgta tagcaaactg accgtggata aaagccgctg gcagcagggc      600

aacgtgttta gctgcagcgt gatgcatgaa gcgctgcata accattatac ccagaaaagc      660

ctgagcctga gcccgggcaa a                                                681


<210>  38
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-YTE-FQQ

<400>  38

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Gln Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Gln Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  39
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc-G4P

<400>  39
gaatctaagt acggccctcc ctgcccaccc tgccctgccc ctgaatttct gggcggaccc       60

tccgtgttcc tgttcccacc caagcccaag gacaccctga tgatcagccg gacccctgaa      120

gtgacctgcg tggtggtgga cgtgtcccag gaagatcccg aggtccagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag      300

tacaagtgca aggtgtccaa caagggcctg cccagctcca tcgagaaaac catcagcaag      360

gccaagggcc agccccgcga gccccaggtc tacacactgc ctcccagcca ggaagagatg      420

accaagaacc aggtgtccct gacctgtctg gtgaaaggct tctaccccag cgatatcgcc      480

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc tcccgtgctg      540

gacagcgacg gcagcttctt tctgtactcc cggctgaccg tggacaagag ccggtggcag      600

gaaggcaacg tcttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagtccctga gcctgagcct gggcaag                                          687


<210>  40
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-G4P

<400>  40

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  41
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  41
cagctgtata gcgcgctggc gaacaaatgc tgccatgtgg gctgcaccaa acgcagcctg       60

gcgcgctttt gc                                                           72


<210>  42
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  


<210>  43
<211>  90
<212>  DNA
<213>  Homo sapiens

<400>  43
gacagctgga tggaagaagt gattaaactg tgtggccgcg aactggtgcg cgcgcagatt       60

gcgatttgcg gcatgagcac ctggagctga                                        90


<210>  44
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      


Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25                  


<210>  45
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human Relaxin 2 chain B variant

<400>  45
agctggatgg aagaagtgat taaactgtgt ggccgcgaac tggtgcgcgc gcagattgcg       60

atttgcggca tgagcacctg gagctga                                           87


<210>  46
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Relaxin 2 chain B variant

<400>  46

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
            20                  25              


<210>  47
<211>  306
<212>  DNA
<213>  Homo sapiens

<400>  47
tctttgtctc aagaggatgc tccacagaca cccagaccag tggccgagat tgtccccagc       60

tttataaaca aagacactga gaccataaac atgatgtccg aattcgtcgc aaatctgcct      120

caggagctta agctcactct ctctgagatg caaccagcac tgcctcagct gcagcagcac      180

gtccctgtgc tgaaggactc cagcctgttg tttgaagaat ttaaaaaact tattcgcaac      240

cgccagtccg aggccgctga ctcaagcccc tcagagctga agtacctggg actggacact      300

cacagt                                                                 306


<210>  48
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  48

Ser Leu Ser Gln Glu Asp Ala Pro Gln Thr Pro Arg Pro Val Ala Glu 
1               5                   10                  15      


Ile Val Pro Ser Phe Ile Asn Lys Asp Thr Glu Thr Ile Asn Met Met 
            20                  25                  30          


Ser Glu Phe Val Ala Asn Leu Pro Gln Glu Leu Lys Leu Thr Leu Ser 
        35                  40                  45              


Glu Met Gln Pro Ala Leu Pro Gln Leu Gln Gln His Val Pro Val Leu 
    50                  55                  60                  


Lys Asp Ser Ser Leu Leu Phe Glu Glu Phe Lys Lys Leu Ile Arg Asn 
65                  70                  75                  80  


Arg Gln Ser Glu Ala Ala Asp Ser Ser Pro Ser Glu Leu Lys Tyr Leu 
                85                  90                  95      


Gly Leu Asp Thr His Ser 
            100         


<210>  49
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  49
gatgtcctgg ctggcctttc cagcagctgc tgcaagtggg ggtgtagcaa aagtgaaatc       60

agtagccttt gc                                                           72


<210>  50
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Val Leu Ala Gly Leu Ser Ser Ser Cys Cys Lys Trp Gly Cys Ser 
1               5                   10                  15      


Lys Ser Glu Ile Ser Ser Leu Cys 
            20                  


<210>  51
<211>  81
<212>  DNA
<213>  Homo sapiens

<400>  51
cgggcagcgc cttacggggt caggctttgc ggccgagaat tcatccgagc agtcatcttc       60

acctgcgggg gctcccggtg g                                                 81


<210>  52
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  52

Arg Ala Ala Pro Tyr Gly Val Arg Leu Cys Gly Arg Glu Phe Ile Arg 
1               5                   10                  15      


Ala Val Ile Phe Thr Cys Gly Gly Ser Arg Trp 
            20                  25          


<210>  53
<211>  192
<212>  DNA
<213>  Homo sapiens

<400>  53
tcagacatcc tggcccacga ggctatggga gataccttcc cggatgcaga tgctgatgaa       60

gacagtctgg caggcgagct ggatgaggcc atggggtcca gcgagtggct ggccctgacc      120

aagtcacccc aggcctttta cagggggcga cccagctggc aaggaacccc tggggttctt      180

cggggcagcc ga                                                          192


<210>  54
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Asp Ile Leu Ala His Glu Ala Met Gly Asp Thr Phe Pro Asp Ala 
1               5                   10                  15      


Asp Ala Asp Glu Asp Ser Leu Ala Gly Glu Leu Asp Glu Ala Met Gly 
            20                  25                  30          


Ser Ser Glu Trp Leu Ala Leu Thr Lys Ser Pro Gln Ala Phe Tyr Arg 
        35                  40                  45              


Gly Arg Pro Ser Trp Gln Gly Thr Pro Gly Val Leu Arg Gly Ser Arg 
    50                  55                  60                  


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  55

Arg Xaa Xaa Xaa Arg Xaa Xaa Ile 
1               5               


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  connector

<400>  56

Gly Gly Ser Pro 
1               


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  connector or linker

<400>  57

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  58

Gly Gly Gly Gly Ser 
1               5   


<210>  59
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  59

Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15      


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
            20                  25          


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved motif 2


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  60

Arg Xaa Xaa Xaa Arg Xaa Xaa Val 
1               5               


<210>  61
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  61
ggaggtggaa gcgcttgtcc tccatgcccg gcgcctgagt tcgagggcgg accctccgtg       60

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      120

tgcgtggtgg tggacgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      180

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa ctccacctac      240

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      300

tgcaaggtct ccaacaaggc cctgcccgcc tccatcgaaa agaccatctc caaggccaag      360

ggccagcccc gcgagcctca ggtgtacaca ctgcccccca gccgggaaga gatgaccaag      420

aaccaggtgt ccctgacctg tctggtgaaa ggcttctacc cctccgatat cgctgtggaa      480

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggactcc      540

gacggctcat tcttcctgta ctccaagctg accgtggaca agtcccggtg gcagcagggc      600

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtct      660

ctaagcttga gccccggcgg aggtggtgga agcggaggag gtggctctgg agggggtgga      720

agcggaggtg gaggtggatc ccagctgtat agcgcgctgg cgaacaaatg ctgccatgtg      780

ggctgcacca aacgcagcct ggcgcgcttt tgcggcggcg gcggcagcgg cggcggcggc      840

agcggcggcg gcggcagcag ctggatggaa gaagtgatta aactgtgtgg ccgcgaactg      900

gtgcgcgcgc agattgcgat ttgcggcatg agcacctgga gc                         942


<210>  62
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  62

Gly Gly Gly Ser Ala Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys 
                245                 250                 255     


Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Trp 
        275                 280                 285             


Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln 
    290                 295                 300                 


Ile Ala Ile Cys Gly Met Ser Thr Trp Ser 
305                 310                 


<210>  63
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  63
ggaggtggaa gcgcttgtcc tccatgcccg gcgcctgagt tcgagggcgg accctccgtg       60

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      120

tgcgtggtgg tggacgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      180

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa ctccacctac      240

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      300

tgcaaggtct ccaacaaggc cctgcccgcc tccatcgaaa agaccatctc caaggccaag      360

ggccagcccc gcgagcctca ggtgtacaca ctgcccccca gccgggaaga gatgaccaag      420

aaccaggtgt ccctgacctg tctggtgaaa ggcttctacc cctccgatat cgctgtggaa      480

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggactcc      540

gacggctcat tcttcctgta ctccaagctg accgtggaca agtcccggtg gcagcagggc      600

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtct      660

ctaagcttga gccccggcgg aggtggtgga agcggaggag gtggctctgg agggggtgga      720

agcggaggtg gaggtggatc ctcctggatg gaggaggtta tcaagctgtg tggacgcgaa      780

ctggtgcgcg ctcagatcgc gatatgcggg atgtccacat ggtcaggcgg cggaggcagc      840

ggcggtggcg gcagcggcgg gggaggttct cagctctact cagcgctcgc taataagtgt      900

tgtcatgtgg gatgcacaaa gcggtctctc gccagattct gc                         942


<210>  64
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  64

Gly Gly Gly Ser Ala Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile Lys Leu 
                245                 250                 255     


Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly Met Ser 
            260                 265                 270         


Thr Trp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly 
    290                 295                 300                 


Cys Thr Lys Arg Ser Leu Ala Arg Phe Cys 
305                 310                 


<210>  65
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  65
cagctgtata gcgcgctggc gaacaaatgc tgccatgtgg gctgcaccaa acgcagcctg       60

gcgcgctttt gcggcggcgg cggcagcggc ggcggcggca gcggcggcgg cggcagcagc      120

tggatggaag aagtgattaa actgtgtggc cgcgaactgg tgcgcgcgca gattgcgatt      180

tgcggcatga gcacctggag cgcggccgcg ggtggaggtg gatccggagg aggtggaagc      240

ggaggaggtg gaagcggagg aggtggaagc gcttgtcctc catgcccggc gcctgagttc      300

gagggcggac cctccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatctcc      360

cggacccccg aagtgacctg cgtggtggtg gacgtgtccc acgaggaccc tgaagtgaag      420

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      480

cagtacaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      540

aacggcaaag agtacaagtg caaggtctcc aacaaggccc tgcccgcctc catcgaaaag      600

accatctcca aggccaaggg ccagccccgc gagcctcagg tgtacacact gccccccagc      660

cgggaagaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaagg cttctacccc      720

tccgatatcg ctgtggaatg ggagtccaac ggccagcccg agaacaacta caagaccacc      780

ccccctgtgc tggactccga cggctcattc ttcctgtact ccaagctgac cgtggacaag      840

tcccggtggc agcagggcaa cgtgttctcc tgctccgtga tgcacgaggc cctgcacaac      900

cactacaccc agaagtctct gtccctgagc cccggc                                936


<210>  66
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  66

Gln Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Ser Trp Met Glu Glu Val Ile Lys Leu 
        35                  40                  45              


Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly Met Ser 
    50                  55                  60                  


Thr Trp Ser Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Pro Pro Cys Pro 
                85                  90                  95      


Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            100                 105                 110         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        115                 120                 125             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    130                 135                 140                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
145                 150                 155                 160 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                165                 170                 175     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            180                 185                 190         


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        195                 200                 205             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    210                 215                 220                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
225                 230                 235                 240 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                245                 250                 255     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            260                 265                 270         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        275                 280                 285             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    290                 295                 300                 


Lys Ser Leu Ser Leu Ser Pro Gly 
305                 310         


<210>  67
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding fusion protein

<400>  67
tcctggatgg aggaggttat caagctgtgt ggacgcgaac tggtgcgcgc tcagatcgcg       60

atatgcggga tgtccacatg gtcaggcggc ggaggcagcg gcggtggcgg cagcggcggg      120

ggaggttctc agctctactc agcgctcgct aataagtgtt gtcatgtggg atgcacaaag      180

cggtctctcg ccagattctg cgcggccgcg ggtggaggtg gatccggagg aggtggaagc      240

ggaggaggtg gaagcggagg aggtggaagc gcttgtcctc catgcccggc gcctgagttc      300

gagggcggac cctccgtgtt cctgttcccc ccaaagccca aggacaccct gatgatctcc      360

cggacccccg aagtgacctg cgtggtggtg gacgtgtccc acgaggaccc tgaagtgaag      420

ttcaattggt acgtggacgg cgtggaagtg cacaacgcca agaccaagcc cagagaggaa      480

cagtacaact ccacctaccg ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      540

aacggcaaag agtacaagtg caaggtctcc aacaaggccc tgcccgcctc catcgaaaag      600

accatctcca aggccaaggg ccagccccgc gagcctcagg tgtacacact gccccccagc      660

cgggaagaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaagg cttctacccc      720

tccgatatcg ctgtggaatg ggagtccaac ggccagcccg agaacaacta caagaccacc      780

ccccctgtgc tggactccga cggctcattc ttcctgtact ccaagctgac cgtggacaag      840

tcccggtggc agcagggcaa cgtgttctcc tgctccgtga tgcacgaggc cctgcacaac      900

cactacaccc agaagtctct gtccctgagc cccggc                                936


<210>  68
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein

<400>  68

Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val Arg 
1               5                   10                  15      


Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Trp Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Leu Tyr Ser Ala 
        35                  40                  45              


Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr Lys Arg Ser Leu Ala 
    50                  55                  60                  


Arg Phe Cys Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Cys Pro Pro Cys Pro 
                85                  90                  95      


Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            100                 105                 110         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        115                 120                 125             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    130                 135                 140                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
145                 150                 155                 160 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                165                 170                 175     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            180                 185                 190         


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        195                 200                 205             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
    210                 215                 220                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
225                 230                 235                 240 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                245                 250                 255     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            260                 265                 270         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        275                 280                 285             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    290                 295                 300                 


Lys Ser Leu Cys Leu Ser Pro Gly 
305                 310         


<210>  69
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Connector

<400>  69

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  70
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Connector

<400>  70

Ala Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Ala 
            20                  


