                         SEQUENCE LISTING

<110>  Glycotope GmbH
 
<120>  Anti-cancer treatments with an anti-MUC1 antibody and an ErbB 
       inhibitor

<130>  59 190 K

<150>  LU100026
<151>  2017-01-27

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR H1

<400>  1

Asn Tyr Trp Met Asn 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDR H1

<400>  2

Asp Ala Trp Met Asp 
1               5   


<210>  3
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  CDR H2

<400>  3

Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  4
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  CDR H2

<400>  4

Glu Ile Arg Ser Lys Ala Asn Asn His Ala Thr Tyr Tyr Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  5
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  CDR H3

<400>  5

His Tyr Tyr Phe Asp Tyr 
1               5       


<210>  6
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR H3

<400>  6

Gly Gly Tyr Gly Phe Asp Tyr 
1               5           


<210>  7
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region

<400>  7

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Ser Leu Gln Met Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  8
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Leu or Met

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Ala or Val

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is Ala or Ser

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa is Gly or Glu

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa is Gly or Ala

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa is Asn or Ser

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa is Leu or Val

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa is Thr or Ala

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa is Val or Leu

<400>  8

Glu Val Xaa Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Xaa Arg Leu Ser Cys Xaa Ala Ser Gly Phe Pro Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Xaa Pro Xaa Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Xaa Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Xaa Ser 
65                  70                  75                  80  


Xaa Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Xaa Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Xaa Thr Val Ser Ser 
        115         


<210>  9
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  heavy chain variable region

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Arg Leu Ser Cys Val Ala Ser Gly Phe Pro Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Tyr Thr Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg His Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR L1

<400>  10

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Phe Phe 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDR L1

<400>  11

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  12
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR L2

<400>  12

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  13
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDR L2

<400>  13

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR L3

<400>  14

Ala Gln Asn Leu Glu Leu Pro Pro Thr 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDR L3

<400>  15

Phe Gln Gly Ser His Val Pro Leu Thr 
1               5                   


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region

<400>  16

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Leu Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  17
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  light chain variable region


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Leu or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  Xaa is Gln or Gly

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Xaa Pro Val Thr Pro Gly 
1               5                   10                  15      


Xaa Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Xaa Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Xaa Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  18
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  light chain vatiable region

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Phe Phe Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Ala 
        


<210>  19
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  19

Pro Asp Thr Arg 
1               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  20

Pro Asp Thr Arg Pro 
1               5   


