                         SEQUENCE LISTING

<110>  I-MAB
 
<120>  ANTI-CD73 ANTIBODIES AND USES THEREOF

<130>  54LW-250265-WO2

<150>  PCT/CN2017/072445
<151>  2017-01-24

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Tyr Ile Asn Tyr Gly Gly Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Asp Tyr Asp Ala Tyr Tyr Glu Ala Leu Asp Asp 
1               5                   10      


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Arg Ala Ser Ser Arg Val Asn Tyr Met His 
1               5                   10  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  7
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly 
    50  


<210>  8
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Glu Ile Val Leu Ser Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr 
    50  


<210>  9
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly 
    50  


<210>  10
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly 
    50  


<210>  11
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly 
    50  


<210>  12
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly 
    50  


<210>  13
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly 
    50  


<210>  14
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly 
    50  


<210>  15
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr 
    50  


<210>  16
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        35                  40                  45              


Ala Thr 
    50  


<210>  17
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        35                  40                  45              


Ala Thr 
    50  


<210>  18
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Ser 
        35                  40                  45              


Ala Thr 
    50  


<210>  19
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr 
    50  


<210>  20
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Glu Ile Val Leu Ser Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr 
    50  


<210>  21
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala 
    50      


<210>  22
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr 
    50  


<210>  23
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr 
    50  


<210>  24
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Arg Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser 
        35                  40                  45              


Ala Thr 
    50  


<210>  25
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala 
    50      


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Thr Gly Tyr Tyr Trp Asn 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Cys Gly Tyr Tyr Trp Asn 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ser Ala Tyr Tyr Trp Asn 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Ser Pro Tyr Tyr Trp Asn 
1               5       


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Tyr Ile Asn Tyr Gly Ala Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Tyr Ile Asn Tyr Gly Pro Ser Asn Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  32
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Tyr Ile Asn Tyr Gly Gly Thr Asn Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Tyr Ile Asn Tyr Gly Gly Cys Asn Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Tyr Ile Asn Tyr Gly Gly Ser Asp Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Tyr Ile Asn Tyr Gly Gly Ser Glu Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Tyr Ile Asn Tyr Gly Gly Ser Gln Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Asp Tyr Asp Ala Tyr Tyr Asp Ala Leu Asp Asp 
1               5                   10      


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Asp Tyr Asp Ala Tyr Tyr Gln Ala Leu Asp Asp 
1               5                   10      


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Asp Tyr Asp Ala Tyr Tyr Asn Ala Leu Asp Asp 
1               5                   10      


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Asp Tyr Asp Ala Tyr Tyr Glu Gly Leu Asp Asp 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Asp Tyr Asp Ala Tyr Tyr Glu Cys Leu Asp Asp 
1               5                   10      


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Arg Ala Thr Ser Arg Val Asn Tyr Met His 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Arg Ala Cys Ser Arg Val Asn Tyr Met His 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Arg Ala Ser Thr Arg Val Asn Tyr Met His 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Arg Ala Ser Cys Arg Val Asn Tyr Met His 
1               5                   10  


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Asn Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Asp Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Glu Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  49
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Gln Asn Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Gln Asp Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Gln Glu Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gln Gln Tyr Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Gln Gln Trp Cys Ser Asn Pro Pro Thr 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Gln Gln Trp Ser Thr Asn Pro Pro Thr 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Gln Gln Trp Ser Cys Asn Pro Pro Thr 
1               5                   


<210>  57
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Gly Ala Thr Gly Thr Ala Cys Ala Gly Cys Thr Thr Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Ala Gly Gly Ala Cys Cys Thr Gly Gly Cys Cys Thr 
            20                  25                  30          


Cys Gly Thr Gly Ala Ala Ala Cys Cys Thr Thr Cys Thr Cys Ala Gly 
        35                  40                  45              


Thr Cys Thr Cys Thr Gly Thr Cys Thr Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Thr Cys Thr Gly Thr Cys Ala Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Thr Cys Cys Ala Thr Cys Ala Cys Cys Ala Gly Thr Gly Gly Thr 
                85                  90                  95      


Thr Ala Thr Thr Ala Cys Thr Gly Gly Ala Ala Cys Thr Gly Gly Ala 
            100                 105                 110         


Thr Cys Cys Gly Gly Cys Ala Gly Thr Thr Thr Cys Cys Ala Gly Gly 
        115                 120                 125             


Ala Ala Ala Cys Ala Ala Ala Cys Thr Gly Gly Ala Ala Thr Gly Gly 
    130                 135                 140                 


Ala Thr Gly Gly Gly Cys Thr Ala Cys Ala Thr Ala Ala Ala Cys Thr 
145                 150                 155                 160 


Ala Cys Gly Gly Cys Gly Gly Thr Ala Gly Cys Ala Ala Thr Gly Gly 
                165                 170                 175     


Cys Thr Ala Cys Ala Ala Cys Cys Cys Ala Thr Cys Thr Cys Thr Cys 
            180                 185                 190         


Ala Ala Ala Ala Gly Thr Cys Gly Gly Ala Thr Cys Thr Cys Cys Ala 
        195                 200                 205             


Thr Cys Ala Cys Thr Cys Gly Gly Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Thr Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Thr Thr Thr Thr Cys 
225                 230                 235                 240 


Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Ala Thr Thr Cys Thr Gly 
                245                 250                 255     


Thr Gly Ala Cys Thr Ala Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Ala Gly Cys Thr Ala Cys Ala Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Gly Ala Gly Ala Cys Thr Ala Thr Gly Ala Thr Gly 
    290                 295                 300                 


Gly Thr Thr Ala Cys Thr Ala Cys Gly Ala Ala Gly Cys Thr Cys Thr 
305                 310                 315                 320 


Gly Gly Ala Cys Gly Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 
                325                 330                 335     


Gly Gly Ala Ala Cys Cys Thr Cys Ala Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Cys Thr Cys Cys Thr Cys Ala 
        355                 360 


<210>  58
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Cys Ala Ala Ala Thr Thr Gly Thr Thr Cys Thr Cys Thr Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Thr Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Cys Cys Ala Gly Gly Gly 
        35                  40                  45              


Gly Ala Gly Ala Ala Gly Gly Thr Cys Ala Cys Ala Ala Thr Gly Ala 
    50                  55                  60                  


Cys Thr Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Thr Cys 
65                  70                  75                  80  


Ala Cys Gly Thr Gly Thr Ala Ala Ala Thr Thr Ala Cys Ala Thr Gly 
                85                  90                  95      


Cys Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala 
            100                 105                 110         


Ala Gly Cys Cys Ala Gly Gly Ala Thr Cys Cys Thr Cys Cys Cys Cys 
        115                 120                 125             


Cys Ala Ala Ala Cys Cys Cys Thr Gly Gly Ala Thr Thr Thr Cys Thr 
    130                 135                 140                 


Gly Cys Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 
145                 150                 155                 160 


Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr Gly Cys 
                165                 170                 175     


Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr 
            180                 185                 190         


Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys Thr Thr 
        195                 200                 205             


Ala Cys Thr Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Thr Ala Gly 
    210                 215                 220                 


Cys Ala Gly Ala Gly Thr Ala Gly Ala Gly Ala Cys Thr Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Thr Gly Cys Thr Gly Cys Cys Ala Cys Thr Thr Ala Thr Thr 
                245                 250                 255     


Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Gly Gly Ala Gly 
            260                 265                 270         


Thr Ala Gly Thr Ala Ala Cys Cys Cys Ala Cys Cys Cys Ala Cys Gly 
        275                 280                 285             


Thr Thr Cys Gly Gly Ala Gly Gly Gly Gly Gly Gly Ala Cys Cys Ala 
    290                 295                 300                 


Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Ala Ala Ala Ala 
305                 310                 315             


<210>  59
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Gly Ala Gly Gly Thr Ala Cys Ala Gly Cys Thr Thr Cys Ala Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Ala Gly Gly Ala Cys Cys Thr Gly Gly Cys Cys Thr 
            20                  25                  30          


Cys Gly Thr Gly Ala Ala Ala Cys Cys Thr Thr Cys Thr Gly Ala Gly 
        35                  40                  45              


Ala Cys Thr Cys Thr Gly Thr Cys Thr Cys Thr Cys Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Gly Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Thr Cys Cys Ala Thr Cys Ala Cys Cys Ala Gly Thr Gly Gly Thr 
                85                  90                  95      


Thr Ala Thr Thr Ala Cys Thr Gly Gly Ala Ala Cys Thr Gly Gly Ala 
            100                 105                 110         


Thr Cys Cys Gly Gly Cys Ala Gly Cys Cys Thr Cys Cys Ala Gly Gly 
        115                 120                 125             


Ala Ala Ala Gly Ala Ala Gly Cys Thr Gly Gly Ala Ala Thr Gly Gly 
    130                 135                 140                 


Ala Thr Gly Gly Gly Cys Thr Ala Cys Ala Thr Cys Ala Ala Cys Thr 
145                 150                 155                 160 


Ala Cys Gly Gly Cys Gly Gly Thr Ala Gly Cys Ala Ala Thr Gly Gly 
                165                 170                 175     


Cys Thr Ala Cys Ala Ala Cys Cys Cys Ala Thr Cys Thr Cys Thr Cys 
            180                 185                 190         


Ala Ala Ala Ala Gly Thr Cys Gly Gly Ala Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Thr Ala Gly Gly Gly Ala Cys Ala Cys Ala Thr Cys 
    210                 215                 220                 


Thr Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Thr Thr Thr Cys Cys 
225                 230                 235                 240 


Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly Thr Thr Cys Thr Gly 
                245                 250                 255     


Thr Gly Ala Cys Thr Gly Cys Thr Gly Cys Cys Gly Ala Cys Ala Cys 
            260                 265                 270         


Ala Gly Cys Thr Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Gly Ala Gly Ala Cys Thr Ala Thr Gly Ala Thr Gly 
    290                 295                 300                 


Cys Thr Thr Ala Cys Thr Ala Cys Gly Ala Ala Gly Cys Thr Cys Thr 
305                 310                 315                 320 


Gly Gly Ala Cys Gly Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Ala 
                325                 330                 335     


Gly Gly Ala Ala Cys Cys Ala Cys Ala Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Cys Thr Cys Cys Thr Cys Ala 
        355                 360 


<210>  60
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Gly Ala Ala Ala Thr Thr Gly Thr Thr Cys Thr Cys Thr Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Cys Cys Cys Thr 
            20                  25                  30          


Gly Thr Cys Thr Cys Thr Gly Thr Cys Thr Cys Cys Ala Gly Gly Gly 
        35                  40                  45              


Gly Ala Gly Ala Gly Gly Gly Cys Cys Ala Cys Ala Cys Thr Gly Thr 
    50                  55                  60                  


Cys Thr Thr Gly Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Thr Cys 
65                  70                  75                  80  


Ala Cys Gly Thr Gly Thr Ala Ala Ala Thr Thr Ala Cys Ala Thr Gly 
                85                  90                  95      


Cys Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala 
            100                 105                 110         


Ala Gly Cys Cys Ala Gly Gly Ala Cys Ala Gly Thr Cys Cys Cys Cys 
        115                 120                 125             


Cys Ala Gly Ala Cys Cys Cys Thr Gly Gly Ala Thr Thr Thr Cys Thr 
    130                 135                 140                 


Gly Cys Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly 
145                 150                 155                 160 


Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr Gly Cys 
                165                 170                 175     


Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr 
            180                 185                 190         


Gly Gly Gly Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys Thr Thr 
        195                 200                 205             


Ala Cys Ala Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Thr Ala Gly 
    210                 215                 220                 


Cys Ala Gly Cys Cys Thr Gly Gly Ala Gly Cys Cys Ala Gly Ala Ala 
225                 230                 235                 240 


Gly Ala Thr Thr Thr Cys Gly Cys Cys Gly Thr Gly Thr Ala Thr Thr 
                245                 250                 255     


Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Gly Gly Ala Gly 
            260                 265                 270         


Thr Ala Gly Thr Ala Ala Cys Cys Cys Ala Cys Cys Cys Ala Cys Gly 
        275                 280                 285             


Thr Thr Cys Gly Gly Ala Gly Gly Gly Gly Gly Gly Ala Cys Cys Ala 
    290                 295                 300                 


Ala Gly Gly Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Ala 
305                 310                 315             


<210>  61
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Met Cys Pro Arg Ala Ala Arg Ala Pro Ala Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Gly Ala Val Leu Trp Pro Ala Ala Gly Ala Trp Glu Leu Thr Ile Leu 
            20                  25                  30          


His Thr Asn Asp Val His Ser Arg Leu Glu Gln Thr Ser Glu Asp Ser 
        35                  40                  45              


Ser Lys Cys Val Asn Ala Ser Arg Cys Met Gly Gly Val Ala Arg Leu 
    50                  55                  60                  


Phe Thr Lys Val Gln Gln Ile Arg Arg Ala Glu Pro Asn Val Leu Leu 
65                  70                  75                  80  


Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr Ile Trp Phe Thr Val Tyr 
                85                  90                  95      


Lys Gly Ala Glu Val Ala His Phe Met Asn Ala Leu Arg Tyr Asp Ala 
            100                 105                 110         


Met Ala Leu Gly Asn His Glu Phe Asp Asn Gly Val Glu Gly Leu Ile 
        115                 120                 125             


Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro Ile Leu Ser Ala Asn Ile 
    130                 135                 140                 


Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile Ser Gly Leu Tyr Leu Pro 
145                 150                 155                 160 


Tyr Lys Val Leu Pro Val Gly Asp Glu Val Val Gly Ile Val Gly Tyr 
                165                 170                 175     


Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn Pro Gly Thr Asn Leu Val 
            180                 185                 190         


Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro Glu Val Asp Lys Leu Lys 
        195                 200                 205             


Thr Leu Asn Val Asn Lys Ile Ile Ala Leu Gly His Ser Gly Phe Glu 
    210                 215                 220                 


Met Asp Lys Leu Ile Ala Gln Lys Val Arg Gly Val Asp Val Val Val 
225                 230                 235                 240 


Gly Gly His Ser Asn Thr Phe Leu Tyr Thr Gly Asn Pro Pro Ser Lys 
                245                 250                 255     


Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile Val Thr Ser Asp Asp Gly 
            260                 265                 270         


Arg Lys Val Pro Val Val Gln Ala Tyr Ala Phe Gly Lys Tyr Leu Gly 
        275                 280                 285             


Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly Asn Val Ile Ser Ser His 
    290                 295                 300                 


Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile Pro Glu Asp Pro Ser Ile 
305                 310                 315                 320 


Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys Leu Asp Asn Tyr Ser Thr 
                325                 330                 335     


Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu Asp Gly Ser Ser Gln Ser 
            340                 345                 350         


Cys Arg Phe Arg Glu Cys Asn Met Gly Asn Leu Ile Cys Asp Ala Met 
        355                 360                 365             


Ile Asn Asn Asn Leu Arg His Thr Asp Glu Met Phe Trp Asn His Val 
    370                 375                 380                 


Ser Met Cys Ile Leu Asn Gly Gly Gly Ile Arg Ser Pro Ile Asp Glu 
385                 390                 395                 400 


Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn Leu Ala Ala Val Leu Pro 
                405                 410                 415     


Phe Gly Gly Thr Phe Asp Leu Val Gln Leu Lys Gly Ser Thr Leu Lys 
            420                 425                 430         


Lys Ala Phe Glu His Ser Val His Arg Tyr Gly Gln Ser Thr Gly Glu 
        435                 440                 445             


Phe Leu Gln Val Gly Gly Ile His Val Val Tyr Asp Leu Ser Arg Lys 
    450                 455                 460                 


Pro Gly Asp Arg Val Val Lys Leu Asp Val Leu Cys Thr Lys Cys Arg 
465                 470                 475                 480 


Val Pro Ser Tyr Asp Pro Leu Lys Met Asp Glu Val Tyr Lys Val Ile 
                485                 490                 495     


Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp Gly Phe Gln Met Ile Lys 
            500                 505                 510         


Asp Glu Leu Leu Arg His Asp Ser Gly Asp Gln Asp Ile Asn Val Val 
        515                 520                 525             


Ser Thr Tyr Ile Ser Lys Met Lys Val Ile Tyr Pro Ala Val Glu Gly 
    530                 535                 540                 


Arg Ile Lys Phe Ser Thr Gly Ser His Cys His Gly Ser Phe Ser Leu 
545                 550                 555                 560 


Ile Phe Leu Ser Leu Trp Ala Val Ile Phe Val Leu Tyr Gln 
                565                 570                 


