                         SEQUENCE LISTING

<110>  Ƽ޹˾
 
<120>  ￹MSLNǶϿԭ߼Ʒӵ

<130>  PIDC1153486P

<160>  141     

<170>  PatentIn version 3.3

<210>  1
<211>  507
<212>  PRT
<213>  Artificial

<220>
<223>  ǶϿԭİ

<400>  1

Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Ala Gln Val Gln Leu Val Gln 
            20                  25                  30          


Ser Gly Ala Glu Val Lys Arg Pro Gly Ala Ser Val Gln Val Ser Cys 
        35                  40                  45              


Arg Ala Ser Gly Tyr Ser Ile Asn Thr Tyr Tyr Met Gln Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Ala Gly Leu Glu Trp Met Gly Val Ile Asn Pro Ser 
65                  70                  75                  80  


Gly Val Thr Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Leu Thr 
                85                  90                  95      


Asn Asp Thr Ser Thr Asn Thr Val Tyr Met Gln Leu Asn Ser Leu Thr 
            100                 105                 110         


Ser Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Ala Leu Trp Gly 
        115                 120                 125             


Asp Phe Gly Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Ile Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Gly Ile Tyr His Trp 
            180                 185                 190         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Tyr Pro Leu 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ser Phe Val 
            260                 265                 270         


Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro 
        275                 280                 285             


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
    290                 295                 300                 


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
305                 310                 315                 320 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
                325                 330                 335     


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg 
            340                 345                 350         


Asn Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        355                 360                 365             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    370                 375                 380                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
385                 390                 395                 400 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                405                 410                 415     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            420                 425                 430         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        435                 440                 445             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    450                 455                 460                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
465                 470                 475                 480 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                485                 490                 495     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505         


<210>  2
<211>  1524
<212>  DNA
<213>  Artificial

<220>
<223>  ǶϿԭĺӵĺ

<400>  2
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc ttcgtgccgg tcttcctgcc agcgaagccc    840

accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg    900

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    960

gacttcgcct gtgatatcta catctgggcg cccttggccg ggacttgtgg ggtccttctc   1020

ctgtcactgg ttatcaccct ttactgcaac cacaggaaca aacggggcag aaagaaactc   1080

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc   1140

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc   1200

aggagcgcag acgcccccgc gtaccagcag ggccagaacc agctctataa cgagctcaat   1260

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg   1320

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat   1380

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg   1440

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac   1500

atgcaggccc tgccccctcg ctaa                                          1524


<210>  3
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  3
ggccaggatg gttcttagac t                                               21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  4
ggatttccag tggcgagaga a                                               21


<210>  5
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  5
gccuguguuc ucuguggacu aug                                             23


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  6
ggugcugcua gucugggucc ugg                                             23


<210>  7
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  7
gacagagaga agggcagaag ugc                                             23


<210>  8
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  8
cagcuucucc aacacaucgg aga                                             23


<210>  9
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  9
ccgugucaca caacugccca acg                                             23


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  10
uaugccacca uugucuuucc uag                                             23


<210>  11
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  11
ugcuaaacug guaccgcaug agc                                             23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  12
gugacagaga gaagggcaga agu                                             23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  13
cugaggaugg acacugcucu ugg                                             23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  1PD1 siRNA

<400>  14
aucggagagc uucgugcuaa acu                                             23


<210>  15
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  15
ggcaacggaa cccagattta t                                               21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  16
ggaacccaaa ttacgtgtac t                                               21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  17
gaacccaaat tacgtgtact a                                               21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  18
gggagaagac tatattgtac a                                               21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  19
gacgtttata gccgaaatga t                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  20
gacactaata caccaggtag a                                               21


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  21
accucacuau ccaaggacug agg                                             23


<210>  22
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  22
augaguugac cuuccuagau gau                                             23


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  23
ggggaaugag uugaccuucc uag                                             23


<210>  24
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  24
cucuggaucc uugcagcagu uag                                             23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  25
cuccucugga uccuugcagc agu                                             23


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  26
uuugugugug aguaugcauc ucc                                             23


<210>  27
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  27
caccuccagu ggaaaucaag uga                                             23


<210>  28
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  28
cacgggacuc uacaucugca agg                                             23


<210>  29
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  29
uucugacuuc cuccucugga ucc                                             23


<210>  30
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ϸTܰϸؿԭ4CTLA4 siRNA

<400>  30
aagucugugc ggcaaccuac aug                                             23


<210>  31
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  31
ggtcggtcag aatgcctatc t                                               21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  32
gccaatgact tacgggactc t                                               21


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  33
gcagagggaa ttcgctcaga a                                               21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  34
ggaaattcgg gcacatcata t                                               21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  35
gattaagaga tgactggact a                                               21


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  36
gagatgactg gactaggtct a                                               21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  37
aggaaauucg ggcacaucau aug                                             23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  38
gacugaugaa agggauguga auu                                             23


<210>  39
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  39
gccacugauu uucaaagaga ucu                                             23


<210>  40
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  40
agcagaguuu ucccauuuuc aga                                             23


<210>  41
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  41
aacuuaaaca ggcaugucau ugc                                             23


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  42
uucagaagau aaugacucac aug                                             23


<210>  43
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  43
gccucuguau uuaagccaac aga                                             23


<210>  44
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  44
ugcucaugug auuguggagu aga                                             23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  45
auguuuucac aucuucccuu uga                                             23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tϸ򵰰ճ׷3TIM3 siRNA

<400>  46
gagagacuuc acugcagccu uuc                                             23


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  47
gattgcctct actcatcact a                                               21


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  48
uccuaaugac aaugggucau acc                                             23


<210>  49
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  49
aagacauugc cugccaugcu ugg                                             23


<210>  50
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  50
gucauaccgc uguucugcaa auu                                             23


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  51
cuccuguaua guuuacuucc uuu                                             23


<210>  52
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  52
uaccgcuguu cugcaaauuu uca                                             23


<210>  53
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  53
aaaacaaacc aggcauuguu uau                                             23


<210>  54
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  54
aacuagaaug cccugugaaa uac                                             23


<210>  55
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  55
gugacuuggu gcaagcucaa ugg                                             23


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  56
auccauggga aagaaucaug uga                                             23


<210>  57
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   Tܰϸ˥ӣBTLA siRNA

<400>  57
uggugcaagc ucaauggaac aac                                             23


<210>  58
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  58
gctgctcacc cttatgaacc t                                               21


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  59
aggacauggu gguggacgag ugc                                             23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  60
ugcucuuccu gcacgauauc agu                                             23


<210>  61
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  61
accucuacug guuccuguac auc                                             23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  62
cccuccaacu cugcuccucu agg                                             23


<210>  63
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  63
cccugagugg acagucgucu ucg                                             23


<210>  64
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  64
cugcuccagg gaagcuucua ugg                                             23


<210>  65
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  65
cgcucaaggu ccuguaugcc acc                                             23


<210>  66
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  66
gaguucacca agcucaacau uua                                             23


<210>  67
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  67
ugcugcugcu cacccuuaug aac                                             23


<210>  68
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  ܰϸ3ףLAG1 siRNA

<400>  68
cccaucuccg ugcucuucuu uga                                             23


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  69
gggacatcgt cgagctattc a                                               21


<210>  70
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  70
ggacatcgtc gagctattca t                                               21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  71
gccaatgtca ccgtggataa t                                               21


<210>  72
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  72
gtcatctgtg gcagtatatc a                                               21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  73
ggatgtagag tagtgttaga t                                               21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  74
ggcaaagtta agaccatcaa t                                               21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  75
gaccaaatcc acgctcaatt a                                               21


<210>  76
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  76
uacugcuuaa aucuuccauc agc                                             23


<210>  77
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  77
gacugagaag uucugucuga uuu                                             23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  78
cuguuucauc acccaaacau acu                                             23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  79
gaagauccuc ccacaucacu aaa                                             23


<210>  80
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  80
uagaccaagg uaaaagugga aca                                             23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  81
aagagguuuu uaucugagcu uga                                             23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  82
uaccugcaca acguucaacc aug                                             23


<210>  83
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  83
gccuggauuc augucucuca uuu                                             23


<210>  84
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  84
cccucggaau uucucugcca agc                                             23


<210>  85
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   IRAK-M siRNA(ϸ-1ؼø3)

<400>  85
ugcugaagau ccucccacau cac                                             23


<210>  86
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  86
gcacctccta cctcttcatg t                                               21


<210>  87
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  87
cgcacuuccg cacauuccgu ucg                                             23


<210>  88
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  88
ggggaggguc ucuggcuuua uuu                                             23


<210>  89
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  89
cagcauuaac ugggaugccg ugu                                             23


<210>  90
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  90
ccaggaccug aacucgcacc ucc                                             23


<210>  91
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  91
uacauauacc caguaucuuu gca                                             23


<210>  92
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  92
gccgacaaug cagucuccac agc                                             23


<210>  93
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  93
ccccugguug uuguagcagc uua                                             23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  94
cugcugugca gaauccuauu uua                                             23


<210>  95
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  95
ugggaugccg uguuauuuug uua                                             23


<210>  96
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   SOCS1 siRNAϸźת1

<400>  96
ucgcaccucc uaccucuuca ugu                                             23


<210>  97
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  97
gcggaaagct gtgaagatac g                                               21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  98
acaaagccct catcgacaga a                                               21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  99
atgccacttc tcagtacatg t                                               21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  100
gtggacttca gtacaactca c                                               21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  101
gtggaattta cttgcctctc c                                               21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  102
gttggatgaa gctaacttac c                                               21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  103
actgggaaga cgtgtaactc t                                               21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  104
aaggaattgc atccaaggta t                                               21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  105
ggaattgcat ccaaggtata c                                               21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  106
ggatgagact ggcaatggtc a                                               21


<210>  107
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  107
uccucaguuu cgggagauca ucc                                             23


<210>  108
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  108
gagucucuca aaucucagga auu                                             23


<210>  109
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  109
agcucuaguc cuuuuugugu aau                                             23


<210>  110
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  110
cacuggaaau guucagaacu ugc                                             23


<210>  111
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  111
augaugaaug ggacaaucuu auc                                             23


<210>  112
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  112
cacacugugu uucaucgagu aca                                             23


<210>  113
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  113
gcagaaccau ccauggacug uga                                             23


<210>  114
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  114
aaagaugugg ccuuuuguga ugg                                             23


<210>  115
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  115
uucagaacuu gccaguuuug ucc                                             23


<210>  116
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   A20 siRNA(-յA20)

<400>  116
augagacugg caauggucac agg                                             23


<210>  117
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  117
gtcaattcca gggagataac t                                               21


<210>  118
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  118
gcctggaagc aatggctcta a                                               21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  119
gcaccaaacc cggaagctat a                                               21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  120
gttgcactcg attgggacag t                                               21


<210>  121
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  121
ggattatgtg aacctacacc t                                               21


<210>  122
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  122
ggaatcacag cgagttcaaa t                                               21


<210>  123
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  123
gcaaggcata gtctcattga a                                               21


<210>  124
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  124
ggtgaagaga gccttagaga t                                               21


<210>  125
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  125
gtgaagagag ccttagagat a                                               21


<210>  126
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  126
aggagcuaag gucuuuucca aug                                             23


<210>  127
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  127
augucgaugc aaaaauugca aaa                                             23


<210>  128
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  128
gucacaugcu ggcagaaauc aaa                                             23


<210>  129
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  129
uccagguuac auggcauuuc uca                                             23


<210>  130
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  130
uugaacuuug aaccugugaa aug                                             23


<210>  131
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  131
uccacaucaa cagcuaaauc auu                                             23


<210>  132
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  132
augcuggcag aaaucaaagc aau                                             23


<210>  133
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  133
ugcagagaau gacaaagaug uca                                             23


<210>  134
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  134
ggcagaacuc accagucaca uca                                             23


<210>  135
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>   CBL-B siRNAE3صøCBL-B

<400>  135
ucgguccugu gauaaugguc acu                                             23


<210>  136
<211>  2053
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN-CAR/iPD1ĺ

<400>  136
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgagcga   1500

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1560

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1620

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1680

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1740

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1800

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1860

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1920

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   1980

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2040

ctgcgccttt ttt                                                      2053


<210>  137
<211>  2057
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN-CAR/iCBL-Bĺ

<400>  137
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgagcga   1500

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1560

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1620

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1680

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1740

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1800

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1860

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1920

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   1980

gaaaggacga aacacctccc caacacagac gccatgattt gcttcaagag agcaaatcat   2040

ggcgtctgtg ttttttt                                                  2057


<210>  138
<211>  2053
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN-CAR/iCTLA4ĺ

<400>  138
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgagcga   1500

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1560

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1620

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1680

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1740

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1800

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1860

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1920

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   1980

gaaaggacga aacacctccc cgcatcactt gggattaata ttcaagagat attaatccca   2040

agtgatgctt ttt                                                      2053


<210>  139
<211>  2360
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN-CAR/iPD1- CBL-Bĺ

<400>  139
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgagcga   1500

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1560

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1620

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1680

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1740

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1800

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1860

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1920

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   1980

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2040

ctgcgccttt tttagctatc gatagctaaa aaaacacaga cgccatgatt tgctctcttg   2100

aagcaaatca tggcgtctgt gttggggaag atctgtggtc tcatacagaa cttataagat   2160

tcccaaatcc aaagacattt cacgtttatg gtgatttccc agaacacata gcgacatgca   2220

aatattgcag ggcgccactc ccctgtccct cacagccatc ttcctgccag ggcgcacgcg   2280

cgctgggtgt tcccgcctag tgacactggg cccgcgattc cttggagcgg gttgatgacg   2340

tcagcgttcg aattgtcgac                                               2360


<210>  140
<211>  2356
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN-CAR/iPD1-CTLA4ĺ

<400>  140
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgagcga   1500

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1560

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1620

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1680

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1740

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1800

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1860

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1920

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   1980

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2040

ctgcgccttt tttagctatc gatagctaaa aagcatcact tgggattaat atctcttgaa   2100

tattaatccc aagtgatgcg gggaagatct gtggtctcat acagaactta taagattccc   2160

aaatccaaag acatttcacg tttatggtga tttcccagaa cacatagcga catgcaaata   2220

ttgcagggcg ccactcccct gtccctcaca gccatcttcc tgccagggcg cacgcgcgct   2280

gggtgttccc gcctagtgac actgggcccg cgattccttg gagcgggttg atgacgtcag   2340

cgttcgaatt gtcgac                                                   2356


<210>  141
<211>  2360
<212>  DNA
<213>  Artificial

<220>
<223>  MSLN-CAR/iPD1- PD1ĺ

<400>  141
atggttctgc tggtgacatc tctcctgctc tgtgaactgc ctcatcccgc ttttctgctc     60

attcccgaca ttcaggctca agtccaactg gtccaaagtg gtgctgaagt caaacgcccg    120

ggtgcctccg tccaagtctc ctgccgtgcc tctggctact cgattaacac ctattacatg    180

cagtgggtcc gtcaagcacc gggtgcaggt ctggaatgga tgggtgtcat caatccgtcc    240

ggcgtgacct catatgcgca gaaatttcaa ggtcgcgtta ccctgacgaa cgataccagc    300

acgaataccg tctacatgca gctgaactct ctgacgagtg cagacaccgc ggtgtattac    360

tgcgcacgtt gggcactgtg gggcgatttc ggcatggatg tttggggcaa aggtacgctg    420

gtgaccgtta gctctggtgg tggtggttct ggtggtggtg gtagtggcgg tggcggttct    480

gatattcaga tgacgcaaag cccgtctacc ctgagtgcct ccattggtga ccgtgttacg    540

atcacctgtc gcgcatccga aggcatctat cattggctgg cttggtacca gcaaaaaccg    600

ggtaaagcgc cgaaactgct gatctataaa gcaagttccc tggcatcggg tgctccgagc    660

cgcttttcag gttcgggtag cggcaccgat ttcacgctga ccatctcatc gctgcagccg    720

gacgatttcg ctacctacta ctgccaacaa tactcaaact acccgctgac cttcggtgga    780

gggaccaagc tggagatcaa acgtgctagc accactaccc cagcaccgag gccacccacc    840

ccggctccta ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca    900

gctggtgggg ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc    960

cctctggctg gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtaag   1020

cgcggtcgga agaagctgct gtacatcttt aagcaaccct tcatgaggcc tgtgcagact   1080

actcaagagg aggacggctg ttcatgccgg ttcccagagg aggaggaagg cggctgcgaa   1140

ctgcgcgtga aattcagccg cagcgcagat gctccagcct accagcaggg gcagaaccag   1200

ctctacaacg aactcaatct tggtcggaga gaggagtacg acgtgctgga caagcggaga   1260

ggacgggacc cagaaatggg cgggaagccg cgcagaaaga atccccaaga gggcctgtac   1320

aacgagctcc aaaaggataa gatggcagaa gcctatagcg agattggtat gaaaggggaa   1380

cgcagaagag gcaaaggcca cgacggactg taccagggac tcagcaccgc caccaaggac   1440

acctatgacg ctcttcacat gcaggccctg ccgcctcggt aatcctactg cgtcgagcga   1500

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc   1560

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc   1620

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt   1680

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgggtcga ccaaggtcgg   1740

gcaggaagag ggcctatttc ccatgattcc ttcatatttg catatacgat acaaggctgt   1800

tagagagata attagaatta atttgactgt aaacacaaag atattagtac aaaatacgtg   1860

acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt ttaaaatgga   1920

ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat atatcttgtg   1980

gaaaggacga aacacctccc caggcgcaga tcaaagagag ttcaagagac tctctttgat   2040

ctgcgccttt tttagctatc gatagctaaa aagcctagag aagtttcagg gaatctcttg   2100

aattccctga aacttctcta ggcggggaag atctgtggtc tcatacagaa cttataagat   2160

tcccaaatcc aaagacattt cacgtttatg gtgatttccc agaacacata gcgacatgca   2220

aatattgcag ggcgccactc ccctgtccct cacagccatc ttcctgccag ggcgcacgcg   2280

cgctgggtgt tcccgcctag tgacactggg cccgcgattc cttggagcgg gttgatgacg   2340

tcagcgttcg aattgtcgac                                               2360


