                         SEQUENCE LISTING

<110>  University of Florida
       Curtiss, Roy  III
       Wang, Shifeng  
 
<120>  INDUCTION OF PROTECTIVE IMMUNITY AGAINST ANTIGENS

<130>  126405-00120

<150>  62/449,228
<151>  2017-01-23

<150>  62/541,293
<151>  2017-08-04

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
atgctaacca catcattaac gttaaataaa gagaaatgga agccgatctg gaataaagcg       60

ctggtttttc tttttgttgc cacgtatttt ctggatggta ttacgcgtta taaacatttg      120

ataatcatac ttatggttat caccgcgatt tatcaggtct cacgctcacc gaaaagtttc      180

ccccctcttt tcaaaaatag cgtattttat agcgtagcag tattatcatt aatccttgtt      240

tattccatac tcatatcgcc agatatgaaa gaaagtttca aggaatttga aaatacggta      300

ctggagggct tcttattata tactttatta attcccgtac tattaaaaga tgaaacaaaa      360

gaaacggttg cgaaaatagt acttttctcc tttttaacaa gtttaggact tcgctgcctt      420

gcagagagta ttctgtatat cgaggactat aataaaggga ttatgccatt cataagctat      480

gcgcatcgac atatgtccga ttccatggtt ttcttatttc cagcattatt gaatatttgg      540

ctgtttagaa aaaatgcaat taagttggtt tttttggtgc ttagcgccat ctaccttttc      600

tttatcctgg gaaccctatc gcgaggggca tggttggcgg tgcttatagt aggtgttctg      660

tgggcaatac tgaaccgcca atggaagtta ataggagttg gtgccatttt attagccatt      720

atcggcgctt tggttatcac tcaacataat aacaaaccag acccagaaca tttactgtat      780

aaattacagc agacagatag ctcatatcgt tatactaacg gaacccaggg caccgcgtgg      840

atactgattc aggaaaaccc gatcaagggc tacggctatg gtaatgatgt gtatgatggt      900

gtttataata aacgcgttgt cgattatcca acgtggacct ttaaagaatc tatcggtccg      960

cataatacca ttctgtacat ctggtttagt gcaggcatat tgggtctggc gagcctggtc     1020

tatttatatg gcgctatcat cagggaaaca gccagctcta ccctcaggaa agtagagata     1080

agcccctaca atgctcatct cttgctattt ttatctttcg tcggttttta tatcgttcgt     1140

ggcaattttg aacaggtcga tattgctcaa attggtatca ttaccggttt tctgctggcg     1200

ctaagaaata gataa                                                      1215


<210>  2
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Met Leu Thr Thr Ser Leu Thr Leu Asn Lys Glu Lys Trp Lys Pro Ile 
1               5                   10                  15      


Trp Asn Lys Ala Leu Val Phe Leu Phe Val Ala Thr Tyr Phe Leu Asp 
            20                  25                  30          


Gly Ile Thr Arg Tyr Lys His Leu Ile Ile Ile Leu Met Val Ile Thr 
        35                  40                  45              


Ala Ile Tyr Gln Val Ser Arg Ser Pro Lys Ser Phe Pro Pro Leu Phe 
    50                  55                  60                  


Lys Asn Ser Val Phe Tyr Ser Val Ala Val Leu Ser Leu Ile Leu Val 
65                  70                  75                  80  


Tyr Ser Ile Leu Ile Ser Pro Asp Met Lys Glu Ser Phe Lys Glu Phe 
                85                  90                  95      


Glu Asn Thr Val Leu Glu Gly Phe Leu Leu Tyr Thr Leu Leu Ile Pro 
            100                 105                 110         


Val Leu Leu Lys Asp Glu Thr Lys Glu Thr Val Ala Lys Ile Val Leu 
        115                 120                 125             


Phe Ser Phe Leu Thr Ser Leu Gly Leu Arg Cys Leu Ala Glu Ser Ile 
    130                 135                 140                 


Leu Tyr Ile Glu Asp Tyr Asn Lys Gly Ile Met Pro Phe Ile Ser Tyr 
145                 150                 155                 160 


Ala His Arg His Met Ser Asp Ser Met Val Phe Leu Phe Pro Ala Leu 
                165                 170                 175     


Leu Asn Ile Trp Leu Phe Arg Lys Asn Ala Ile Lys Leu Val Phe Leu 
            180                 185                 190         


Val Leu Ser Ala Ile Tyr Leu Phe Phe Ile Leu Gly Thr Leu Ser Arg 
        195                 200                 205             


Gly Ala Trp Leu Ala Val Leu Ile Val Gly Val Leu Trp Ala Ile Leu 
    210                 215                 220                 


Asn Arg Gln Trp Lys Leu Ile Gly Val Gly Ala Ile Leu Leu Ala Ile 
225                 230                 235                 240 


Ile Gly Ala Leu Val Ile Thr Gln His Asn Asn Lys Pro Asp Pro Glu 
                245                 250                 255     


His Leu Leu Tyr Lys Leu Gln Gln Thr Asp Ser Ser Tyr Arg Tyr Thr 
            260                 265                 270         


Asn Gly Thr Gln Gly Thr Ala Trp Ile Leu Ile Gln Glu Asn Pro Ile 
        275                 280                 285             


Lys Gly Tyr Gly Tyr Gly Asn Asp Val Tyr Asp Gly Val Tyr Asn Lys 
    290                 295                 300                 


Arg Val Val Asp Tyr Pro Thr Trp Thr Phe Lys Glu Ser Ile Gly Pro 
305                 310                 315                 320 


His Asn Thr Ile Leu Tyr Ile Trp Phe Ser Ala Gly Ile Leu Gly Leu 
                325                 330                 335     


Ala Ser Leu Val Tyr Leu Tyr Gly Ala Ile Ile Arg Glu Thr Ala Ser 
            340                 345                 350         


Ser Thr Leu Arg Lys Val Glu Ile Ser Pro Tyr Asn Ala His Leu Leu 
        355                 360                 365             


Leu Phe Leu Ser Phe Val Gly Phe Tyr Ile Val Arg Gly Asn Phe Glu 
    370                 375                 380                 


Gln Val Asp Ile Ala Gln Ile Gly Ile Ile Thr Gly Phe Leu Leu Ala 
385                 390                 395                 400 


Leu Arg Asn Arg 
                


<210>  3
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
atgactgaca acaataccgc attaaagaag gctggcctga aagtaacgct tcctcgttta       60

aaaattctgg aagttcttca ggaaccagat aaccatcacg tcagtgcgga agatttatac      120

aaacgcctga tcgacatggg tgaagaaatc ggtctggcaa ccgtataccg tgtgctgaac      180

cagtttgacg atgccggtat cgtgacccgc cataattttg aaggcggtaa atccgttttt      240

gaactgacgc aacagcatca tcacgaccat cttatctgcc ttgattgcgg aaaagtgatt      300

gaatttagtg atgactctat tgaagcgcgc cagcgtgaaa ttgcggcgaa acacggtatt      360

cgtttaacta atcacagcct ctatctttac ggccactgcg ctgaaggcga ctgccgcgaa      420

gacgagcacg cgcacgatga cgcgactaaa taa                                   453


<210>  4
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Met Thr Asp Asn Asn Thr Ala Leu Lys Lys Ala Gly Leu Lys Val Thr 
1               5                   10                  15      


Leu Pro Arg Leu Lys Ile Leu Glu Val Leu Gln Glu Pro Asp Asn His 
            20                  25                  30          


His Val Ser Ala Glu Asp Leu Tyr Lys Arg Leu Ile Asp Met Gly Glu 
        35                  40                  45              


Glu Ile Gly Leu Ala Thr Val Tyr Arg Val Leu Asn Gln Phe Asp Asp 
    50                  55                  60                  


Ala Gly Ile Val Thr Arg His Asn Phe Glu Gly Gly Lys Ser Val Phe 
65                  70                  75                  80  


Glu Leu Thr Gln Gln His His His Asp His Leu Ile Cys Leu Asp Cys 
                85                  90                  95      


Gly Lys Val Ile Glu Phe Ser Asp Asp Ser Ile Glu Ala Arg Gln Arg 
            100                 105                 110         


Glu Ile Ala Ala Lys His Gly Ile Arg Leu Thr Asn His Ser Leu Tyr 
        115                 120                 125             


Leu Tyr Gly His Cys Ala Glu Gly Asp Cys Arg Glu Asp Glu His Ala 
    130                 135                 140                 


His Asp Asp Ala Thr Lys 
145                 150 


<210>  5
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
atgactgaca acaataccgc attaaagaag gctggcctga aagtaacgct tcctcgttta       60

aaaattctgg aagttcttca ggaaccagat aaccatcacg tcagtgcgga agatttatac      120

aaacgcctga tcgacatggg tgaagaaatc ggtctggcaa ccgtataccg tgtgctgaac      180

cagtttgacg atgccggtat cgtgacccgc cataattttg aaggcggtaa atccgttttt      240

gaactgacgc aacagcatca tcacgaccat cttatctgcc ttgattgcgg aaaagtgatt      300

gaatttagtg atgactctat tgaagcgcgc cagcgtgaaa ttgcggcgaa acacggtatt      360

cgtttaacta atcacagcct ctatctttac ggccactgcg ctgaaggcga ctgccgcgaa      420

gacgagcacg cgcacgatga cgcgactaaa taa                                   453


<210>  6
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Met Thr Asp Asn Asn Thr Ala Leu Lys Lys Ala Gly Leu Lys Val Thr 
1               5                   10                  15      


Leu Pro Arg Leu Lys Ile Leu Glu Val Leu Gln Glu Pro Asp Asn His 
            20                  25                  30          


His Val Ser Ala Glu Asp Leu Tyr Lys Arg Leu Ile Asp Met Gly Glu 
        35                  40                  45              


Glu Ile Gly Leu Ala Thr Val Tyr Arg Val Leu Asn Gln Phe Asp Asp 
    50                  55                  60                  


Ala Gly Ile Val Thr Arg His Asn Phe Glu Gly Gly Lys Ser Val Phe 
65                  70                  75                  80  


Glu Leu Thr Gln Gln His His His Asp His Leu Ile Cys Leu Asp Cys 
                85                  90                  95      


Gly Lys Val Ile Glu Phe Ser Asp Asp Ser Ile Glu Ala Arg Gln Arg 
            100                 105                 110         


Glu Ile Ala Ala Lys His Gly Ile Arg Leu Thr Asn His Ser Leu Tyr 
        115                 120                 125             


Leu Tyr Gly His Cys Ala Glu Gly Asp Cys Arg Glu Asp Glu His Ala 
    130                 135                 140                 


His Asp Asp Ala Thr Lys 
145                 150 


<210>  7
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
atgccgatta ctatagggaa tggtttttta aaaagtgaaa tccttaccaa ctccccaagg       60

aatacgaaag aagcatggtg gaaagtttta tgggaaaaaa ttaaagactt ctttttttct      120

actggcaaag caaaagcgga ccgttgtcta catgagatgt tgtttgccga acgcgccccc      180

acacgagagc ggcttacaga gatttttttt gagttgaaag agttagcctg cgcatcgcaa      240

agagatagat ttcaggttca taatcctcat gaaaatgatg ccaccattat tcttcgcatc      300

atggatcaaa acgaagagaa cgaattgtta cgtatcactc aaaataccga tacctttagc      360

tgtgaagtca tggggaatct ttatttttta atgaaagatc gcccggatat tttaaaatcg      420

catccacaaa tgacggccat gattaagaga agatatagcg aaatcgtaga ctaccccctc      480

ccttcgacat tatgtctcaa tcctgctggc gcgccgatat tatcggttcc attagacaac      540

atagaggggt atttatatac tgaattgaga aaaggacatt tagatgggtg gaaagcgcaa      600

gaaaaggcaa cctacctggc agcgaaaatt cagtctggga ttgaaaagac aacgcgcatt      660

ttacaccatg cgaatatatc cgaaagtact cagcaaaacg catttttaga aacaatggcg      720

atgtgtggat taaaacagct tgaaatacca ccaccgcata cccacatacc tattgaaaaa      780

atggtaaaag aggttttact agcggataag acgtttcagg cgttcctcgt aacggatccc      840

agcaccagcc aaagtatgtt agctgagata gtcgaagcca tctctgatca ggtttttcac      900

gccattttta gaatagaccc ccaggctata caaaaaatgg cggaagaaca gttaaccacg      960

ctacacgttc gctcagaaca acaaagcggc tgtttatgtt gttttttata a              1011


<210>  8
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Pro Ile Thr Ile Gly Asn Gly Phe Leu Lys Ser Glu Ile Leu Thr 
1               5                   10                  15      


Asn Ser Pro Arg Asn Thr Lys Glu Ala Trp Trp Lys Val Leu Trp Glu 
            20                  25                  30          


Lys Ile Lys Asp Phe Phe Phe Ser Thr Gly Lys Ala Lys Ala Asp Arg 
        35                  40                  45              


Cys Leu His Glu Met Leu Phe Ala Glu Arg Ala Pro Thr Arg Glu Arg 
    50                  55                  60                  


Leu Thr Glu Ile Phe Phe Glu Leu Lys Glu Leu Ala Cys Ala Ser Gln 
65                  70                  75                  80  


Arg Asp Arg Phe Gln Val His Asn Pro His Glu Asn Asp Ala Thr Ile 
                85                  90                  95      


Ile Leu Arg Ile Met Asp Gln Asn Glu Glu Asn Glu Leu Leu Arg Ile 
            100                 105                 110         


Thr Gln Asn Thr Asp Thr Phe Ser Cys Glu Val Met Gly Asn Leu Tyr 
        115                 120                 125             


Phe Leu Met Lys Asp Arg Pro Asp Ile Leu Lys Ser His Pro Gln Met 
    130                 135                 140                 


Thr Ala Met Ile Lys Arg Arg Tyr Ser Glu Ile Val Asp Tyr Pro Leu 
145                 150                 155                 160 


Pro Ser Thr Leu Cys Leu Asn Pro Ala Gly Ala Pro Ile Leu Ser Val 
                165                 170                 175     


Pro Leu Asp Asn Ile Glu Gly Tyr Leu Tyr Thr Glu Leu Arg Lys Gly 
            180                 185                 190         


His Leu Asp Gly Trp Lys Ala Gln Glu Lys Ala Thr Tyr Leu Ala Ala 
        195                 200                 205             


Lys Ile Gln Ser Gly Ile Glu Lys Thr Thr Arg Ile Leu His His Ala 
    210                 215                 220                 


Asn Ile Ser Glu Ser Thr Gln Gln Asn Ala Phe Leu Glu Thr Met Ala 
225                 230                 235                 240 


Met Cys Gly Leu Lys Gln Leu Glu Ile Pro Pro Pro His Thr His Ile 
                245                 250                 255     


Pro Ile Glu Lys Met Val Lys Glu Val Leu Leu Ala Asp Lys Thr Phe 
            260                 265                 270         


Gln Ala Phe Leu Val Thr Asp Pro Ser Thr Ser Gln Ser Met Leu Ala 
        275                 280                 285             


Glu Ile Val Glu Ala Ile Ser Asp Gln Val Phe His Ala Ile Phe Arg 
    290                 295                 300                 


Ile Asp Pro Gln Ala Ile Gln Lys Met Ala Glu Glu Gln Leu Thr Thr 
305                 310                 315                 320 


Leu His Val Arg Ser Glu Gln Gln Ser Gly Cys Leu Cys Cys Phe Leu 
                325                 330                 335     


<210>  9
<211>  1083
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
gtgaaaccag taacgttata cgatgtcgca gagtatgccg gtgtctctta tcagaccgtt       60

tcccgcgtgg tgaaccaggc cagccacgtt tctgcgaaaa cgcgggaaaa agtggaagcg      120

gcgatggcgg agctgaatta cattcccaac cgcgtggcac aacaactggc gggcaaacag      180

tcgttgctga ttggcgttgc cacctccagt ctggccctgc acgcgccgtc gcaaattgtc      240

gcggcgatta aatctcgcgc cgatcaactg ggtgccagcg tggtggtgtc gatggtagaa      300

cgaagcggcg tcgaagcctg taaagcggcg gtgcacaatc ttctcgcgca acgcgtcagt      360

gggctgatca ttaactatcc gctggatgac caggatgcca ttgctgtgga agctgcctgc      420

actaatgttc cggcgttatt tcttgatgtc tctgaccaga cacccatcaa cagtattatt      480

ttctcccatg aagacggtac gcgactgggc gtggagcatc tggtcgcatt gggtcaccag      540

caaatcgcgc tgttagcggg cccattaagt tctgtctcgg cgcgtctgcg tctggctggc      600

tggcataaat atctcactcg caatcaaatt cagccgatag cggaacggga aggcgactgg      660

agtgccatgt ccggttttca acaaaccatg caaatgctga atgagggcat cgttcccact      720

gcgatgctgg ttgccaacga tcagatggcg ctgggcgcaa tgcgcgccat taccgagtcc      780

gggctgcgcg ttggtgcgga tatctcggta gtgggatacg acgataccga agacagctca      840

tgttatatcc cgccgttaac caccatcaaa caggattttc gcctgctggg gcaaaccagc      900

gtggaccgct tgctgcaact ctctcagggc caggcggtga agggcaatca gctgttgccc      960

gtctcactgg tgaaaagaaa aaccaccctg gcgcccaata cgcaaaccgc ctctccccgc     1020

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag     1080

tga                                                                   1083


<210>  10
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Lys Pro Val Thr Leu Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser 
1               5                   10                  15      


Tyr Gln Thr Val Ser Arg Val Val Asn Gln Ala Ser His Val Ser Ala 
            20                  25                  30          


Lys Thr Arg Glu Lys Val Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile 
        35                  40                  45              


Pro Asn Arg Val Ala Gln Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile 
    50                  55                  60                  


Gly Val Ala Thr Ser Ser Leu Ala Leu His Ala Pro Ser Gln Ile Val 
65                  70                  75                  80  


Ala Ala Ile Lys Ser Arg Ala Asp Gln Leu Gly Ala Ser Val Val Val 
                85                  90                  95      


Ser Met Val Glu Arg Ser Gly Val Glu Ala Cys Lys Ala Ala Val His 
            100                 105                 110         


Asn Leu Leu Ala Gln Arg Val Ser Gly Leu Ile Ile Asn Tyr Pro Leu 
        115                 120                 125             


Asp Asp Gln Asp Ala Ile Ala Val Glu Ala Ala Cys Thr Asn Val Pro 
    130                 135                 140                 


Ala Leu Phe Leu Asp Val Ser Asp Gln Thr Pro Ile Asn Ser Ile Ile 
145                 150                 155                 160 


Phe Ser His Glu Asp Gly Thr Arg Leu Gly Val Glu His Leu Val Ala 
                165                 170                 175     


Leu Gly His Gln Gln Ile Ala Leu Leu Ala Gly Pro Leu Ser Ser Val 
            180                 185                 190         


Ser Ala Arg Leu Arg Leu Ala Gly Trp His Lys Tyr Leu Thr Arg Asn 
        195                 200                 205             


Gln Ile Gln Pro Ile Ala Glu Arg Glu Gly Asp Trp Ser Ala Met Ser 
    210                 215                 220                 


Gly Phe Gln Gln Thr Met Gln Met Leu Asn Glu Gly Ile Val Pro Thr 
225                 230                 235                 240 


Ala Met Leu Val Ala Asn Asp Gln Met Ala Leu Gly Ala Met Arg Ala 
                245                 250                 255     


Ile Thr Glu Ser Gly Leu Arg Val Gly Ala Asp Ile Ser Val Val Gly 
            260                 265                 270         


Tyr Asp Asp Thr Glu Asp Ser Ser Cys Tyr Ile Pro Pro Leu Thr Thr 
        275                 280                 285             


Ile Lys Gln Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu 
    290                 295                 300                 


Leu Gln Leu Ser Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro 
305                 310                 315                 320 


Val Ser Leu Val Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr 
                325                 330                 335     


Ala Ser Pro Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln 
            340                 345                 350         


Val Ser Arg Leu Glu Ser Gly Gln 
        355                 360 


<210>  11
<211>  4844
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
gggcgaattc gagctcggta ccctcgaggc tgaatttcat tacgaccagt ctaaaaagcg       60

cctgaattcg cgaccttctc gttactgaca ggaaaatggg ccattggcaa ccagggaaag      120

atgaacgtga tgatgttcac aatttgctga attgtggtga tgtgatgctc accgcatttc      180

ctgaaaattc acgctgtatc ttgaaaaatc gacgtttttt acgtggtttt ccgtcgaaaa      240

tttaaggtaa gaacctgacc tcgtgattac tatttcgccg tgttgacgac atcaggaggc      300

cagtatgacc gtattacata gtgtggattt ttttccgtct ggtaacgcgt ccgtggcgat      360

agaaccccgg ctcccgcagg cggattttcc tgaacatcat catgattttc atgaaattgt      420

gattgtcgaa catggcacgg gtattcatgt gtttaatggg cagccctata ccatcaccgg      480

tggcacggtc tgtttcgtac gcgatcatga tcggcatctg tatgaacata ccgataatct      540

gtgtctgacc aatgtgctgt atcgctcgcc ggatcgattt cagtttctcg ccgggctgaa      600

tcagttgctg ccacaagagc tggatgggca gtatccgtct cactggcgcg ttaaccacag      660

cgtattgcag caggtgcgac agctggttgc acagatggaa cagcaggaag gggaaaatga      720

tttaccctcg accgccagtc gcgagatctt gtttatgcaa ttactgctct tgctgcgtaa      780

aagcagtttg caggagaacc tggaaaacag cgcatcacgt ctcaacttgc ttctggcctg      840

gctggaggac cattttgccg atgaggtgaa ttgggatgcc gtggcggatc aattttctct      900

ttcactgcgt acgctacatc ggcagcttaa gcagcaaacg ggactgacgc ctcagcgata      960

cctgaaccgc ctgcgactga tgaaagcccg acatctgcta cgccacagcg aggccagcgt     1020

tactgacatc gcctatcgct gtggattcag cgacagtaac cacttttcga cgctttttcg     1080

ccgagagttt aactggtcac cgcgtgatat tcgccaggga cgggatggct ttctgcaata     1140

acgcgaatct tctcaacgta tttgtacgcc atattgcgaa taatcaactt cgttctctgg     1200

ccgaggtagc cacggtggcg catcagttaa aacttctcaa agatgatttt tttgccagcg     1260

accagcaggc agtcgctgtg gctgaccgtt atccgcaaga tgtctttgct gaacatacac     1320

atgatttttg tgagctggtg attgtctggc gcggtaatgg cctgcatgta ctcaacgatc     1380

gcccttatcg cattacccgt ggcgatctct tttacattca tgctgacgat aaacactcct     1440

acgcttccgt taacgatctg gttttgcaga atattattta ttgcccggag cgtctgaagc     1500

tgaatcttga ctggcagggg gcgattccgg gatttaacgc cagcgcaggg caaccacact     1560

ggcgcttagg tagcatgggg atggcgcagg cgcggcaggt tatcggtcag cttgagcatg     1620

aaagtagtca gcatgtgccg tttgctaacg aaatggctga gttgctgttc gggcagttgg     1680

tgatgttgct gaatcgccat cgttacacca gtgattcgtt gccgccaaca tccagcgaaa     1740

cgttgctgga taagctgatt acccggctgg cggctagcct gaaaagtccc tttgcgctgg     1800

ataaattttg tgatgaggca tcgtgcagtg agcgcgtttt gcgtcagcaa tttcgccagc     1860

agactggaat gaccatcaat caatatctgc gacaggtcag agtgtgtcat gcgcaatatc     1920

ttctccagca tagccgcctg ttaatcagtg atatttcgac cgaatgtggc tttgaagata     1980

gtaactattt ttcggtggtg tttacccggg aaaccgggat gacgcccagc cagtggcgtc     2040

atctcaattc gcagaaagat taatctagat aaataaaagc agtttacaac tcctagaatt     2100

gtgaatatat tatcacaatt ctaggataga ataataaaag atctctgcag gcatgcaagc     2160

ttgagtattc tatagtgtca cctaaatagc ttggcgtaat catggtcata gctgtttcct     2220

gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt     2280

aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc     2340

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg     2400

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     2460

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     2520

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     2580

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     2640

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     2700

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     2760

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     2820

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     2880

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     2940

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     3000

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     3060

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     3120

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     3180

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     3240

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     3300

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     3360

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     3420

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     3480

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     3540

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     3600

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     3660

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     3720

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     3780

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     3840

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     3900

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     3960

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     4020

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     4080

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     4140

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     4200

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     4260

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4320

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc     4380

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtctcgc gcgtttcggt     4440

gatgacggtg aaaacctctg acacatgcag ctcccggaga cggtcacagc ttgtctgtaa     4500

gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg     4560

ggctggctta actatgcggc atcagagcag attgtactga gagtgcacca tatgcggtgt     4620

gaaataccgc acagatgcgt aaggagaaaa taccgcatca ggcgccattc gccattcagg     4680

ctgcgcaact gttgggaagg gcgatcggtg cgggcctctt cgctattacg ccagctggcg     4740

aaagggggat gtgctgcaag gcgattaagt tgggtaacgc cagggttttc ccagtcacga     4800

cgttgtaaaa cgacggccag tgaattgtaa tacgactcac tata                      4844


<210>  12
<211>  4228
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
gggcgaattc gagctcggta ccctcgagtc cataatcagg taatgccgcg ggtgatggat       60

gatgtcgtaa tattgggcac tccctttcag ttgctcaatt atgttatttc acactgctat      120

tgagataatt cacaagtgtg cgctcgctcg caaaataaaa tggaatgatg aaactgggta      180

attccgctag cttttgataa aaattttctc aaagccggtt acgtattacc ggttttgagt      240

ttttgcatga ttcagcagga aaagaaccat gtttactaaa cgtcaccgca tcacattact      300

gttcaatgcc aataaagcct atgaccggca ggtagtagaa ggcgtagggg aatatttaca      360

ggcgtcacaa tcggaatggg atattttcat tgaagaagat ttccgcgccc gcattgataa      420

aatcaaggac tggttaggag atggcgtcat tgccgacttc gacgacaaac agatcgagca      480

agcgctggct gatgtcgacg tccccattgt tggggttggc ggctcgtatc accttgcaga      540

aagttaccca cccgttcatt acattgccac cgataactat gcgctggttg aaagcgcatt      600

tttgcattta aaagagaaag gcgttaaccg ctttgctttt tatggtcttc cggaatcaag      660

cggcaaacgt tgggccactg agcgcgaata tgcatttcgt cagcttgtcg ccgaagaaaa      720

gtatcgcgga gtggtttatc aggggttaga aaccgcgcca gagaactggc aacacgcgca      780

aaatcggctg gcagactggc tacaaacgct accaccgcaa accgggatta ttgccgttac      840

tgacgcccga gcgcggcata ttctgcaagt atgtgaacat ctacatattc ccgtaccgga      900

aaaattatgc gtgattggca tcgataacga agaactgacc cgctatctgt cgcgtgtcgc      960

cctttcttcg gtcgctcagg gcgcgcggca aatgggctat caggcggcaa aactgttgca     1020

tcgattatta gataaagaag aaatgccgct acagcgaatt ttggtcccac cagttcgcgt     1080

cattgaacgg cgctcaacag attatcgctc gctgaccgat cccgccgtta ttcaggccat     1140

gcattacatt cgtaatcacg cctgtaaagg gattaaagtg gatcaggtac tggatgcggt     1200

cgggatctcg cgctccaatc ttgagaagcg ttttaaagaa gaggtgggtg aaaccatcca     1260

tgccatgatt catgccgaga agctggagaa agcgcgcagt ctgctgattt caaccacctt     1320

gtcgatcaat gagatatcgc aaatgtgcgg ttatccatcg ctgcaatatt tctactctgt     1380

ttttaaaaaa gcatatgaca cgacgccaaa agagtatcgc gatgtaaata gcgaggtcat     1440

gttgtaattc tagataaata aaagcagttt acaactccta gaattgtgaa tatattatca     1500

caattctagg atagaataat aaaagatctc tgcaggcatg caagcttgag tattctatag     1560

tgtcacctaa atagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     1620

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctgggtgcct     1680

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     1740

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     1800

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     1860

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     1920

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     1980

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     2040

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     2100

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     2160

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     2220

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     2280

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     2340

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     2400

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     2460

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     2520

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     2580

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     2640

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     2700

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     2760

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     2820

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     2880

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     2940

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     3000

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     3060

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     3120

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     3180

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     3240

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     3300

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     3360

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     3420

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     3480

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     3540

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     3600

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     3660

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     3720

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     3780

aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc     3840

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca     3900

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg     3960

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat     4020

gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg     4080

aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg     4140

caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg     4200

ccagtgaatt gtaatacgac tcactata                                        4228


