                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  TREATMENT OF CANCERS USING ANTI-EMP2 ANTIBODY AND PD-1/PDL-1 
       PATHWAY ANTAGONIST COMBINATION THERAPY

<130>  008074-5066-WO

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Val Leu Leu Ala Phe Ile Ile Ala Phe His Ile Thr Ser Ala 
1               5                   10                  15      


Ala Leu Leu Phe Ile Ala Thr Val Asp Asn Ala Trp Trp Val Gly Asp 
            20                  25                  30          


Glu Phe Phe Ala Asp Val Trp Arg Ile Cys Thr Asn Asn Thr Asn Cys 
        35                  40                  45              


Thr Val Ile Asn Asp Ser Phe Gln Glu Tyr Ser Thr Leu Gln Ala Val 
    50                  55                  60                  


Gln Ala Thr Met Ile Leu Ser Thr Ile Leu Cys Cys Ile Ala Phe Phe 
65                  70                  75                  80  


Ile Phe Val Leu Gln Leu Phe Arg Leu Lys Gln Gly Glu Arg Phe Val 
                85                  90                  95      


Leu Thr Ser Ile Ile Gln Leu Met Ser Cys Leu Cys Val Met Ile Ala 
            100                 105                 110         


Ala Ser Ile Tyr Thr Asp Arg Arg Glu Asp Ile His Asp Lys Asn Ala 
        115                 120                 125             


Lys Phe Tyr Pro Val Thr Arg Glu Gly Ser Tyr Gly Tyr Ser Tyr Ile 
    130                 135                 140                 


Leu Ala Trp Val Ala Phe Ala Cys Thr Phe Ile Ser Gly Met Met Tyr 
145                 150                 155                 160 


Leu Ile Leu Arg Lys Arg Lys 
                165         


<210>  2
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide sequence of human EMP2.

<400>  2

Glu Asp Ile His Asp Lys Asn Ala Lys Phe Tyr Pro Val Thr Arg Glu 
1               5                   10                  15      


Gly Ser Tyr Gly 
            20  


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 heavy chain variable region domain

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Arg Lys Ser Ala Gly Ile Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 variant 1 light chain variable region domain

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  5
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 variant 2 light chain variable region domain

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  6
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 heavy chain

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Gly Arg Lys Ser Ala Gly Ile Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  7
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 variant 1 light chain

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Ser Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  8
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 Variant 2 light chain

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 parental light chain variable region domain

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105     


<210>  10
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 parental light chain

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain CDR1

<400>  11

Ser Tyr Ala Met His 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain CDR2

<400>  12

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable heavy chain CDR3

<400>  13

Asp Arg Arg Gly Arg Lys Ser Ala Gly Ile Asp Tyr 
1               5                   10          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain CDR1

<400>  14

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain CDR2

<400>  15

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain CDR3

<400>  16

Leu Gln Asp Tyr Ser Gly Trp Thr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic variable light chain CDR3

<400>  17

Leu Gln Asp Tyr Asn Gly Trp Thr 
1               5               


<210>  18
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 Parental HC-hIgG1

<400>  18

Met Asp Pro Lys Gly Ser Leu Ser Trp Arg Ile Leu Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Glu Leu Ser Tyr Gly Gln Val Gln Leu Val Gln Ser Gly 
            20                  25                  30          


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser 
65                  70                  75                  80  


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                85                  90                  95      


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Arg Gly Arg Lys 
        115                 120                 125             


Ser Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 


<210>  19
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 Parental LC-hKappa

<400>  19

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  20
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 LC Variant 1-hKappa

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Ser Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  21
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 LC Variant 2-hKappa

<400>  21

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  22
<211>  1425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 Parental HC-hIgG1

<400>  22

Ala Thr Gly Gly Ala Cys Cys Cys Cys Ala Ala Gly Gly Gly Cys Ala 
1               5                   10                  15      


Gly Cys Cys Thr Gly Ala Gly Cys Thr Gly Gly Ala Gly Ala Ala Thr 
            20                  25                  30          


Cys Cys Thr Gly Cys Thr Gly Thr Thr Cys Cys Thr Gly Ala Gly Cys 
        35                  40                  45              


Cys Thr Gly Gly Cys Cys Thr Thr Cys Gly Ala Gly Cys Thr Gly Ala 
    50                  55                  60                  


Gly Cys Thr Ala Cys Gly Gly Cys Cys Ala Gly Gly Thr Gly Cys Ala 
65                  70                  75                  80  


Gly Cys Thr Gly Gly Thr Gly Cys Ala Gly Thr Cys Thr Gly Gly Cys 
                85                  90                  95      


Gly Gly Cys Gly Gly Ala Gly Thr Gly Gly Thr Gly Cys Ala Gly Cys 
            100                 105                 110         


Cys Thr Gly Gly Ala Ala Gly Ala Thr Cys Cys Cys Thr Gly Ala Gly 
        115                 120                 125             


Ala Cys Thr Gly Thr Cys Cys Thr Gly Thr Gly Cys Cys Gly Cys Cys 
    130                 135                 140                 


Thr Cys Cys Gly Gly Cys Thr Thr Cys Ala Cys Cys Thr Thr Cys Thr 
145                 150                 155                 160 


Cys Cys Ala Gly Cys Thr Ala Cys Gly Cys Thr Ala Thr Gly Cys Ala 
                165                 170                 175     


Cys Thr Gly Gly Gly Thr Gly Cys Gly Ala Cys Ala Gly Gly Cys Cys 
            180                 185                 190         


Cys Cys Thr Gly Gly Cys Ala Ala Gly Gly Gly Ala Cys Thr Gly Gly 
        195                 200                 205             


Ala Ala Thr Gly Gly Gly Thr Gly Gly Cys Cys Gly Thr Gly Ala Thr 
    210                 215                 220                 


Cys Thr Cys Cys Thr Ala Cys Gly Ala Cys Gly Gly Cys Thr Cys Cys 
225                 230                 235                 240 


Ala Ala Cys Ala Ala Gly Thr Ala Cys Thr Ala Cys Gly Cys Cys Gly 
                245                 250                 255     


Ala Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys Gly 
            260                 265                 270         


Gly Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Cys Gly Gly 
        275                 280                 285             


Gly Ala Cys Ala Ala Cys Thr Cys Cys Ala Ala Gly Ala Ala Cys Ala 
    290                 295                 300                 


Cys Cys Cys Thr Gly Thr Ala Cys Cys Thr Gly Cys Ala Gly Ala Thr 
305                 310                 315                 320 


Gly Ala Ala Cys Thr Cys Cys Cys Thr Gly Cys Gly Gly Gly Cys Cys 
                325                 330                 335     


Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly Thr 
            340                 345                 350         


Ala Cys Thr Ala Cys Thr Gly Cys Gly Cys Cys Ala Gly Ala Gly Ala 
        355                 360                 365             


Cys Ala Gly Ala Cys Gly Gly Gly Gly Cys Ala Gly Ala Ala Ala Gly 
    370                 375                 380                 


Thr Cys Cys Gly Cys Cys Gly Gly Cys Ala Thr Cys Gly Ala Thr Thr 
385                 390                 395                 400 


Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys 
                405                 410                 415     


Cys Cys Thr Cys Gly Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Cys 
            420                 425                 430         


Thr Cys Thr Gly Cys Thr Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly 
        435                 440                 445             


Gly Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys Cys 
    450                 455                 460                 


Thr Cys Thr Gly Gly Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly Cys 
465                 470                 475                 480 


Ala Ala Gly Ala Gly Cys Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Gly Ala Ala Cys Cys Gly Cys Cys Gly Cys Cys Cys Thr Gly Gly Gly 
            500                 505                 510         


Cys Thr Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Gly Gly Ala Cys 
        515                 520                 525             


Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly 
    530                 535                 540                 


Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Gly Gly Ala Ala 
545                 550                 555                 560 


Cys Ala Gly Cys Gly Gly Cys Gly Cys Thr Cys Thr Gly Ala Cys Cys 
                565                 570                 575     


Ala Gly Cys Gly Gly Ala Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr 
            580                 585                 590         


Thr Cys Cys Cys Thr Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala 
        595                 600                 605             


Gly Ala Gly Cys Ala Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys 
    610                 615                 620                 


Thr Cys Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly 
625                 630                 635                 640 


Thr Gly Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Gly 
                645                 650                 655     


Cys Ala Gly Cys Cys Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly 
            660                 665                 670         


Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly 
        675                 680                 685             


Thr Gly Ala Ala Cys Cys Ala Cys Ala Ala Gly Cys Cys Cys Thr Cys 
    690                 695                 700                 


Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys 
705                 710                 715                 720 


Ala Ala Gly Ala Ala Gly Gly Thr Gly Gly Ala Gly Cys Cys Thr Ala 
                725                 730                 735     


Ala Gly Ala Gly Cys Thr Gly Cys Gly Ala Cys Ala Ala Gly Ala Cys 
            740                 745                 750         


Cys Cys Ala Cys Ala Cys Cys Thr Gly Cys Cys Cys Thr Cys Cys Cys 
        755                 760                 765             


Thr Gly Cys Cys Cys Cys Gly Cys Cys Cys Cys Cys Gly Ala Gly Cys 
    770                 775                 780                 


Thr Gly Cys Thr Gly Gly Gly Cys Gly Gly Ala Cys Cys Cys Ala Gly 
785                 790                 795                 800 


Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys Thr 
                805                 810                 815     


Cys Cys Cys Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala 
            820                 825                 830         


Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Cys Gly 
        835                 840                 845             


Cys Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys Cys 
    850                 855                 860                 


Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly 
865                 870                 875                 880 


Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Gly Gly Ala Cys Cys Cys 
                885                 890                 895     


Cys Gly Ala Gly Gly Thr Gly Ala Ala Gly Thr Thr Cys Ala Ala Cys 
            900                 905                 910         


Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly 
        915                 920                 925             


Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly Cys 
    930                 935                 940                 


Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Thr Cys Gly Gly 
945                 950                 955                 960 


Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Thr 
                965                 970                 975     


Cys Cys Ala Cys Cys Thr Ala Cys Cys Gly Cys Gly Thr Gly Gly Thr 
            980                 985                 990         


Gly Ala Gly Cys Gly Thr Gly Cys  Thr Gly Ala Cys Cys  Gly Thr Gly 
        995                 1000                 1005             


Cys Thr  Gly Cys Ala Cys Cys  Ala Gly Gly Ala Cys  Thr Gly Gly 
    1010                 1015                 1020             


Cys Thr  Gly Ala Ala Cys Gly  Gly Cys Ala Ala Gly  Gly Ala Gly 
    1025                 1030                 1035             


Thr Ala  Cys Ala Ala Gly Thr  Gly Cys Ala Ala Gly  Gly Thr Gly 
    1040                 1045                 1050             


Ala Gly  Cys Ala Ala Cys Ala  Ala Gly Gly Cys Cys  Cys Thr Gly 
    1055                 1060                 1065             


Cys Cys  Cys Gly Cys Thr Cys  Cys Cys Ala Thr Cys  Gly Ala Gly 
    1070                 1075                 1080             


Ala Ala  Gly Ala Cys Cys Ala  Thr Cys Ala Gly Cys  Ala Ala Gly 
    1085                 1090                 1095             


Gly Cys  Cys Ala Ala Gly Gly  Gly Cys Cys Ala Gly  Cys Cys Cys 
    1100                 1105                 1110             


Cys Gly  Gly Gly Ala Gly Cys  Cys Thr Cys Ala Gly  Gly Thr Gly 
    1115                 1120                 1125             


Thr Ala  Cys Ala Cys Cys Cys  Thr Gly Cys Cys Cys  Cys Cys Cys 
    1130                 1135                 1140             


Ala Gly  Cys Cys Gly Cys Gly  Ala Cys Gly Ala Gly  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Cys Ala Ala Gly Ala  Ala Cys Cys Ala Gly  Gly Thr Gly 
    1160                 1165                 1170             


Ala Gly  Cys Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Cys Thr Gly 
    1175                 1180                 1185             


Gly Thr  Gly Ala Ala Gly Gly  Gly Cys Thr Thr Cys  Thr Ala Cys 
    1190                 1195                 1200             


Cys Cys  Cys Thr Cys Cys Gly  Ala Cys Ala Thr Cys  Gly Cys Cys 
    1205                 1210                 1215             


Gly Thr  Gly Gly Ala Gly Thr  Gly Gly Gly Ala Gly  Ala Gly Cys 
    1220                 1225                 1230             


Ala Ala  Cys Gly Gly Cys Cys  Ala Gly Cys Cys Thr  Gly Ala Gly 
    1235                 1240                 1245             


Ala Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Cys Cys 
    1250                 1255                 1260             


Ala Cys  Cys Cys Cys Thr Cys  Cys Cys Gly Thr Gly  Cys Thr Gly 
    1265                 1270                 1275             


Gly Ala  Cys Ala Gly Cys Gly  Ala Cys Gly Gly Cys  Ala Gly Cys 
    1280                 1285                 1290             


Thr Thr  Cys Thr Thr Cys Cys  Thr Gly Thr Ala Cys  Ala Gly Cys 
    1295                 1300                 1305             


Ala Ala  Gly Cys Thr Gly Ala  Cys Cys Gly Thr Gly  Gly Ala Cys 
    1310                 1315                 1320             


Ala Ala  Gly Thr Cys Cys Cys  Gly Gly Thr Gly Gly  Cys Ala Gly 
    1325                 1330                 1335             


Cys Ala  Gly Gly Gly Cys Ala  Ala Cys Gly Thr Gly  Thr Thr Cys 
    1340                 1345                 1350             


Ala Gly  Cys Thr Gly Cys Ala  Gly Cys Gly Thr Gly  Ala Thr Gly 
    1355                 1360                 1365             


Cys Ala  Cys Gly Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Ala Cys 
    1370                 1375                 1380             


Ala Ala  Cys Cys Ala Cys Thr  Ala Cys Ala Cys Cys  Cys Ala Gly 
    1385                 1390                 1395             


Ala Ala  Gly Ala Gly Cys Cys  Thr Gly Ala Gly Cys  Cys Thr Gly 
    1400                 1405                 1410             


Ala Gly  Cys Cys Cys Cys Gly  Gly Ala Thr Ala Gly  
    1415                 1420                 1425 


<210>  23
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 Parental LC-hKappa

<400>  23

Ala Thr Gly Gly Ala Gly Ala Cys Cys Gly Ala Cys Ala Cys Cys Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Cys Cys 
        35                  40                  45              


Gly Gly Cys Thr Cys Cys Ala Cys Cys Gly Gly Ala Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys 
65                  70                  75                  80  


Cys Cys Cys Cys Thr Cys Cys Ala Gly Cys Cys Thr Gly Thr Cys Thr 
                85                  90                  95      


Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly Gly Cys Gly Ala Cys Ala 
            100                 105                 110         


Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly 
        115                 120                 125             


Thr Cys Ala Gly Gly Cys Cys Thr Cys Cys Cys Ala Gly Gly Ala Cys 
    130                 135                 140                 


Ala Thr Cys Thr Cys Cys Ala Ala Cys Thr Ala Cys Cys Thr Gly Ala 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala 
                165                 170                 175     


Gly Cys Cys Cys Gly Gly Cys Ala Ala Gly Gly Cys Cys Cys Cys Cys 
            180                 185                 190         


Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Gly 
        195                 200                 205             


Cys Thr Gly Cys Cys Ala Gly Cys Thr Cys Thr Cys Thr Gly Cys Ala 
    210                 215                 220                 


Gly Thr Cys Cys Gly Gly Cys Gly Thr Gly Cys Cys Cys Thr Cys Thr 
225                 230                 235                 240 


Ala Gly Ala Thr Thr Cys Thr Cys Cys Gly Gly Cys Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Ala Cys Thr Thr 
            260                 265                 270         


Thr Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys 
        275                 280                 285             


Thr Cys Cys Cys Thr Gly Cys Ala Gly Cys Cys Cys Gly Ala Gly Gly 
    290                 295                 300                 


Ala Cys Thr Thr Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Thr Cys Thr Gly Cys Ala Ala Gly Ala Cys Thr Ala Cys 
                325                 330                 335     


Ala Ala Cys Gly Gly Cys Thr Gly Gly Ala Cys Cys Thr Thr Cys Gly 
            340                 345                 350         


Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly Gly Thr 
        355                 360                 365             


Gly Gly Ala Cys Ala Thr Cys Ala Ala Gly Cys Gly Gly Ala Cys Cys 
    370                 375                 380                 


Gly Thr Gly Gly Cys Cys Gly Cys Cys Cys Cys Cys Ala Gly Cys Gly 
385                 390                 395                 400 


Thr Gly Thr Thr Cys Ala Thr Cys Thr Thr Cys Cys Cys Thr Cys Cys 
                405                 410                 415     


Cys Ala Gly Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Thr Gly 
            420                 425                 430         


Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Cys Cys Ala 
        435                 440                 445             


Gly Cys Gly Thr Gly Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr 
    450                 455                 460                 


Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys 
465                 470                 475                 480 


Cys Gly Cys Gly Ala Gly Gly Cys Cys Ala Ala Gly Gly Thr Gly Cys 
                485                 490                 495     


Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala 
            500                 505                 510         


Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Ala Gly Cys Gly Gly Cys 
        515                 520                 525             


Ala Ala Cys Ala Gly Cys Cys Ala Gly Gly Ala Gly Ala Gly Cys Gly 
    530                 535                 540                 


Thr Gly Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly Ala Cys Thr Cys 
545                 550                 555                 560 


Cys Ala Ala Gly Gly Ala Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys 
                565                 570                 575     


Ala Gly Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Ala Cys Cys Cys 
            580                 585                 590         


Thr Gly Ala Cys Cys Cys Thr Gly Ala Gly Cys Ala Ala Gly Gly Cys 
        595                 600                 605             


Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly 
625                 630                 635                 640 


Ala Gly Gly Thr Gly Ala Cys Cys Cys Ala Cys Cys Ala Gly Gly Gly 
                645                 650                 655     


Ala Cys Thr Gly Thr Cys Thr Ala Gly Cys Cys Cys Cys Gly Thr Gly 
            660                 665                 670         


Ala Cys Cys Ala Ala Gly Ala Gly Cys Thr Thr Cys Ala Ala Cys Cys 
        675                 680                 685             


Gly Gly Gly Gly Cys Gly Ala Gly Thr Gly Cys Thr Ala Ala 
    690                 695                 700         


<210>  24
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 LC Variant 1-hKappa

<400>  24

Ala Thr Gly Gly Ala Gly Ala Cys Cys Gly Ala Cys Ala Cys Cys Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Cys Cys 
        35                  40                  45              


Gly Gly Cys Thr Cys Cys Ala Cys Cys Gly Gly Ala Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys 
65                  70                  75                  80  


Cys Cys Cys Cys Thr Cys Cys Ala Gly Cys Cys Thr Gly Thr Cys Thr 
                85                  90                  95      


Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly Gly Cys Gly Ala Cys Ala 
            100                 105                 110         


Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly 
        115                 120                 125             


Thr Cys Ala Gly Gly Cys Cys Thr Cys Cys Cys Ala Gly Gly Ala Cys 
    130                 135                 140                 


Ala Thr Cys Thr Cys Cys Ala Ala Cys Thr Ala Cys Cys Thr Gly Ala 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala 
                165                 170                 175     


Gly Cys Cys Cys Gly Gly Cys Ala Ala Gly Gly Cys Cys Cys Cys Cys 
            180                 185                 190         


Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Gly 
        195                 200                 205             


Cys Thr Gly Cys Cys Ala Gly Cys Thr Cys Thr Cys Thr Gly Cys Ala 
    210                 215                 220                 


Gly Thr Cys Cys Gly Gly Cys Gly Thr Gly Cys Cys Cys Thr Cys Thr 
225                 230                 235                 240 


Ala Gly Ala Thr Thr Cys Thr Cys Cys Gly Gly Cys Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Ala Cys Thr Thr 
            260                 265                 270         


Thr Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys 
        275                 280                 285             


Thr Cys Cys Cys Thr Gly Cys Ala Gly Cys Cys Cys Gly Ala Gly Gly 
    290                 295                 300                 


Ala Cys Thr Thr Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Thr Cys Thr Gly Cys Ala Ala Gly Ala Cys Thr Ala Cys 
                325                 330                 335     


Ala Gly Cys Gly Gly Cys Thr Gly Gly Ala Cys Cys Thr Thr Cys Gly 
            340                 345                 350         


Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly Gly Thr 
        355                 360                 365             


Gly Gly Ala Cys Ala Thr Cys Ala Ala Gly Cys Gly Gly Ala Cys Cys 
    370                 375                 380                 


Gly Thr Gly Gly Cys Cys Gly Cys Cys Cys Cys Cys Ala Gly Cys Gly 
385                 390                 395                 400 


Thr Gly Thr Thr Cys Ala Thr Cys Thr Thr Cys Cys Cys Thr Cys Cys 
                405                 410                 415     


Cys Ala Gly Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Thr Gly 
            420                 425                 430         


Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Cys Cys Ala 
        435                 440                 445             


Gly Cys Gly Thr Gly Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr 
    450                 455                 460                 


Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys 
465                 470                 475                 480 


Cys Gly Cys Gly Ala Gly Gly Cys Cys Ala Ala Gly Gly Thr Gly Cys 
                485                 490                 495     


Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala 
            500                 505                 510         


Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Ala Gly Cys Gly Gly Cys 
        515                 520                 525             


Ala Ala Cys Ala Gly Cys Cys Ala Gly Gly Ala Gly Ala Gly Cys Gly 
    530                 535                 540                 


Thr Gly Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly Ala Cys Thr Cys 
545                 550                 555                 560 


Cys Ala Ala Gly Gly Ala Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys 
                565                 570                 575     


Ala Gly Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Ala Cys Cys Cys 
            580                 585                 590         


Thr Gly Ala Cys Cys Cys Thr Gly Ala Gly Cys Ala Ala Gly Gly Cys 
        595                 600                 605             


Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly 
625                 630                 635                 640 


Ala Gly Gly Thr Gly Ala Cys Cys Cys Ala Cys Cys Ala Gly Gly Gly 
                645                 650                 655     


Ala Cys Thr Gly Thr Cys Thr Ala Gly Cys Cys Cys Cys Gly Thr Gly 
            660                 665                 670         


Ala Cys Cys Ala Ala Gly Ala Gly Cys Thr Thr Cys Ala Ala Cys Cys 
        675                 680                 685             


Gly Gly Gly Gly Cys Gly Ala Gly Thr Gly Cys Thr Ala Ala 
    690                 695                 700         


<210>  25
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PG-101 LC Variant 2-hKappa

<400>  25

Ala Thr Gly Gly Ala Gly Ala Cys Cys Gly Ala Cys Ala Cys Cys Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Thr Gly Cys Cys Cys 
        35                  40                  45              


Gly Gly Cys Thr Cys Cys Ala Cys Cys Gly Gly Ala Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly Thr Cys 
65                  70                  75                  80  


Cys Cys Cys Cys Thr Cys Cys Ala Gly Cys Cys Thr Gly Thr Cys Thr 
                85                  90                  95      


Gly Cys Cys Thr Cys Thr Gly Thr Gly Gly Gly Cys Gly Ala Cys Ala 
            100                 105                 110         


Gly Ala Gly Thr Gly Ala Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly 
        115                 120                 125             


Thr Cys Ala Gly Gly Cys Cys Thr Cys Cys Cys Ala Gly Gly Ala Cys 
    130                 135                 140                 


Ala Thr Cys Thr Cys Cys Ala Ala Cys Thr Ala Cys Cys Thr Gly Ala 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala 
                165                 170                 175     


Gly Cys Cys Cys Gly Gly Cys Ala Ala Gly Gly Cys Cys Cys Cys Cys 
            180                 185                 190         


Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Gly 
        195                 200                 205             


Cys Thr Gly Cys Cys Ala Gly Cys Thr Cys Thr Cys Thr Gly Cys Ala 
    210                 215                 220                 


Gly Thr Cys Cys Gly Gly Cys Gly Thr Gly Cys Cys Cys Thr Cys Thr 
225                 230                 235                 240 


Ala Gly Ala Thr Thr Cys Thr Cys Cys Gly Gly Cys Thr Cys Thr Gly 
                245                 250                 255     


Gly Cys Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Ala Cys Thr Thr 
            260                 265                 270         


Thr Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys 
        275                 280                 285             


Thr Cys Cys Cys Thr Gly Cys Ala Gly Cys Cys Cys Gly Ala Gly Gly 
    290                 295                 300                 


Ala Cys Thr Thr Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Gly Thr Cys Thr Gly Cys Ala Ala Gly Ala Cys Thr Ala Cys 
                325                 330                 335     


Ala Ala Cys Cys Thr Gly Thr Gly Gly Ala Cys Cys Thr Thr Cys Gly 
            340                 345                 350         


Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly Gly Thr 
        355                 360                 365             


Gly Gly Ala Cys Ala Thr Cys Ala Ala Gly Cys Gly Gly Ala Cys Cys 
    370                 375                 380                 


Gly Thr Gly Gly Cys Cys Gly Cys Cys Cys Cys Cys Ala Gly Cys Gly 
385                 390                 395                 400 


Thr Gly Thr Thr Cys Ala Thr Cys Thr Thr Cys Cys Cys Thr Cys Cys 
                405                 410                 415     


Cys Ala Gly Cys Gly Ala Cys Gly Ala Gly Cys Ala Gly Cys Thr Gly 
            420                 425                 430         


Ala Ala Gly Thr Cys Thr Gly Gly Cys Ala Cys Cys Gly Cys Cys Ala 
        435                 440                 445             


Gly Cys Gly Thr Gly Gly Thr Gly Thr Gly Cys Cys Thr Gly Cys Thr 
    450                 455                 460                 


Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys Thr Ala Cys Cys Cys Cys 
465                 470                 475                 480 


Cys Gly Cys Gly Ala Gly Gly Cys Cys Ala Ala Gly Gly Thr Gly Cys 
                485                 490                 495     


Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala 
            500                 505                 510         


Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly Ala Gly Cys Gly Gly Cys 
        515                 520                 525             


Ala Ala Cys Ala Gly Cys Cys Ala Gly Gly Ala Gly Ala Gly Cys Gly 
    530                 535                 540                 


Thr Gly Ala Cys Cys Gly Ala Gly Cys Ala Gly Gly Ala Cys Thr Cys 
545                 550                 555                 560 


Cys Ala Ala Gly Gly Ala Cys Ala Gly Cys Ala Cys Cys Thr Ala Cys 
                565                 570                 575     


Ala Gly Cys Cys Thr Gly Ala Gly Cys Ala Gly Cys Ala Cys Cys Cys 
            580                 585                 590         


Thr Gly Ala Cys Cys Cys Thr Gly Ala Gly Cys Ala Ala Gly Gly Cys 
        595                 600                 605             


Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Ala Gly Cys Ala Cys 
    610                 615                 620                 


Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly Cys Cys Thr Gly Cys Gly 
625                 630                 635                 640 


Ala Gly Gly Thr Gly Ala Cys Cys Cys Ala Cys Cys Ala Gly Gly Gly 
                645                 650                 655     


Ala Cys Thr Gly Thr Cys Thr Ala Gly Cys Cys Cys Cys Gly Thr Gly 
            660                 665                 670         


Ala Cys Cys Ala Ala Gly Ala Gly Cys Thr Thr Cys Ala Ala Cys Cys 
        675                 680                 685             


Gly Gly Gly Gly Cys Gly Ala Gly Thr Gly Cys Thr Ala Ala 
    690                 695                 700         


