                               SEQUENCE LISTING

<110> ALNYLAM PHARMACEUTICALS, INC.
 
<120> ENDOSOMAL CLEAVABLE LINKERS

<130> 051058-088781-PCT

<140> PCT/US2018/014213
<141> 2018-01-18

<150> 62/447,786
<151> 2017-01-18

<160> 70    

<170> PatentIn version 3.5

<210> 1
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 2
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 3
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 4
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 5
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 6
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210> 7
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210> 8
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 9
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 10
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine 

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Norleucine 

<400> 10
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Xaa Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Xaa Ile Asp Gly 
        35                  40      


<210> 11
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210> 13
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210> 14
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 15
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210> 16
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
His His His His His Trp Tyr Gly 
1               5               


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10  


<210> 19
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 19
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 20
<211> 14
<212> PRT
<213> Human immunodeficiency virus 

<400> 20
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210> 21
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Signal sequence based peptide 

<400> 21
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 22
<211> 18
<212> PRT
<213> Mus sp.

<400> 22
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 23
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 26
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Bacterial cell wall permeating peptide 

<400> 26
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 27
<211> 37
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      LL-37 peptide 
 
<400> 27
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 28
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      cecropin P1 peptide 

<400> 28
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 29
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Alpha-defensin peptide 

<400> 29
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 30
<211> 36
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Beta-defensin peptide 

<400> 30
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 31
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      PR-39 peptide 

<400> 31
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 32
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      indolicidin peptide 
 
<400> 32
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 33
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RFGF peptide 

<400> 33
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 34
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      RFGF analogue peptide 

<400> 34
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 35
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      bactenecin peptide 
 
<400> 35
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 36
<211> 13
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
gccagguaag uau                                                          13


<210> 37
<211> 12
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
ccagguaagu au                                                           12


<210> 38
<211> 11
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
cagguaagua u                                                            11


<210> 39
<211> 10
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
cagguaagua                                                              10


<210> 40
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
aacaguguuc uugcucuaua a                                                 21


<210> 41
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
caggaucauc ucaagucuua a                                                 21


<210> 42
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
uuauagagca agaacacugu uuu                                               23


<210> 43
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
uuaagacuug agaugauccu ggc                                               23


<210> 44
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
auagagcaag aacacuguuu u                                                 21


<210> 45
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 45
acaggaucau cucaagucuu aa                                                22


<210> 46
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
caggaucauc ucaagucuua a                                                 21


<210> 47
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
aacaguguuc uugcucuaua a                                                 21


<210> 48
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 48
gatcaggauc aucucaaguc uuaa                                              24


<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 49
gatcaggauc aucucaaguc uuaa                                              24


<210> 50
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 50
aacaguguuc uugcucuaua agatcaggau caucucaagu cuuaa                       45


<210> 51
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 51
aacaguguuc uugcucuaua agatcaggau caucucaagu cuuaa                       45


<210> 52
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
gaucaggauc aucucaaguc uuaa                                              24


<210> 53
<211> 24
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
gaucaggauc aucucaaguc uuaa                                              24


<210> 54
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 55
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 56
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 57
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 58
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 59
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 59
aacaguguuc uugcucuaua auatcaggau caucucaagu cuuaa                       45


<210> 60
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 60
aacaguguuc uugcucuaua agatcaggau caucucaagu cuuaa                       45


<210> 61
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 61
aacaguguuc uugcucuaua agagcaggau caucucaagu cuuaa                       45


<210> 62
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 62
aacaguguuc uugcucuaua agatcaggau caucucaagu cuuaa                       45


<210> 63
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
aacaguguuc uugcucuaua auagcaggau caucucaagu cuuaa                       45


<210> 64
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 65
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 65
aacaguguuc uugcucuaua atttcaggau caucucaagu cuuaa                       45


<210> 66
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
aacaguguuc uugcucuaua auuucaggau caucucaagu cuuaa                       45


<210> 67
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 67
aacaguguuc uugcucuaua agatcaggau caucucaagu cuuaa                       45


<210> 68
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 68
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 69
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
aacaguguuc uugcucuaua agaucaggau caucucaagu cuuaa                       45


<210> 70
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
aacaguguuc uugcucuaua auuucaggau caucucaagu cuuaa                       45


