                         SEQUENCE LISTING

<110>  F1 Oncology Inc.
 
<120>  CHIMERIC ANTIGEN RECEPTORS AGAINST AXL OR ROR2 AND METHODS OF USE
        THEREOF

<130>  F1.002.WO.01

<150>  62/447,898
<151>  2017-01-18

<150>  62/467,059
<151>  2017-03-03

<150>  62/530,193
<151>  2017-07-08

<160>  161   

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD137 Co-stimulatory domain

<400>  1

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  2
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD28 Co-stimulatory domain

<400>  2

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  3
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic IC-delta Co-stimulatory domain

<400>  3

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala 
            20                  25                  30          


Ala Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  4
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic ICOS Co-stimulatory domain

<400>  4

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  5
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic OX40 Co-stimulatory domain

<400>  5

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  6
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD27 Co-stimulatory domain

<400>  6

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  7
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic BLTA Co-stimulatory domain

<400>  7

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  8
<211>  187
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD30 Co-stimulatory domain

<400>  8

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  9
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic GITR Co-stimulatory domain

<400>  9

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  10
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic HVEM Co-stimulatory domain

<400>  10

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  11
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z isoform 1 Activating domain

<400>  11

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  12
<211>  164
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z isoform 2 Activating domain

<400>  12

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z 3 Activating domain

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z 4 Activating domain

<400>  14

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z 5 Activating domain

<400>  15

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z 6 Activating domain

<400>  16

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  17
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3D 1 Activating domain

<400>  17

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  18
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3D 2 Activating domain

<400>  18

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  19
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3D 3 Activating domain

<400>  19

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  20
<211>  206
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3E 1 Activating domain

<400>  20

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Met Ser 
        115                 120                 125             


Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu Leu 
    130                 135                 140                 


Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro 
145                 150                 155                 160 


Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn Lys 
                165                 170                 175     


Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys 
            180                 185                 190         


Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205     


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3E 2 Activating domain

<400>  21

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  22
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3G 1 Activating domain

<400>  22

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  23
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3G 2 Activating domain

<400>  23

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  24
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD79A 1 Activating domain

<400>  24

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  25
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD79A 2 Activating domain

<400>  25

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD79A 3 Activating domain

<400>  26

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic DAP12 1 Activating domain

<400>  27

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  28
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic DAP12 2 Activating domain

<400>  28

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
            100                 105         


<210>  29
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic DAP12 3 Activating domain

<400>  29

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  30
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic DAP12 4 Activating domain

<400>  30

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic DAP12 5 Activating domain

<400>  31

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  32
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic FCERlG 1 Activating domain

<400>  32

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  33
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic FCERlG 2 Activating domain

<400>  33

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic DAP10 Activating domain

<400>  34

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  35
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD28 Activating domain

<400>  35

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  36
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic ZAP70 Activating domain

<400>  36

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic HA Epitope

<400>  37

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic FLAG Epitope

<400>  38

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic c-myc Epitope

<400>  39

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic His5 Affinity

<400>  40

His His His His His 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic HisX6 Affinity

<400>  41

His His His His His His 
1               5       


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Strep Tag Affinity

<400>  42

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic RYIRS Affinity

<400>  43

Arg Tyr Ile Arg Ser 
1               5   


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic FHHT Affinity

<400>  44

Phe His His Thr 
1               


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Affinity

<400>  45

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  46
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD8 alpha Transmembrane domain

<400>  46

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  47
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD8 beta Transmembrane domain

<400>  47

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  48
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD4 Transmembrane domain

<400>  48

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  49
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3 zeta  Transmembrane domain

<400>  49

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  50
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD28 Transmembrane domain

<400>  50

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  51
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic OX40 Transmembrane domain

<400>  51

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  52
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD7  Transmembrane domain

<400>  52

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 1

<400>  53

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  54
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 2

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 3

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 4

<400>  56

Gly Gly Ser Gly 
1               


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 5

<400>  57

Gly Gly Ser Gly Gly 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 6

<400>  58

Gly Ser Gly Ser Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 7

<400>  59

Gly Ser Gly Gly Gly 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 8

<400>  60

Gly Gly Gly Ser Gly 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Linker 9

<400>  61

Gly Ser Ser Ser Gly 
1               5   


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 1

<400>  62

Cys Pro Pro Cys 
1               


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 2

<400>  63

Asp Lys Thr His Thr 
1               5   


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 3

<400>  64

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 4

<400>  65

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 5

<400>  66

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 6

<400>  67

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 7

<400>  68

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 8

<400>  69

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 9

<400>  70

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 10

<400>  71

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 11

<400>  72

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  73
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Hinge 12

<400>  73

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  74
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD8 Signal peptide

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  75
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD8 Stalk-TM

<400>  75

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  76
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD28 Stalk-TM

<400>  76

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val 
65      


<210>  77
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic 2A-1 Cleavage signal

<400>  77

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  78
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic eTAG Elimination domain

<400>  78

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl 4007V VH  Conditionally active scFv

<400>  79

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl 4007V VL  Conditionally active scFv

<400>  80

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu His Phe Ser Pro Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  81
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VL 4 Conditionally active scFv

<400>  81

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
        35                  40                  45              


Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  82
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 R98H VH Conditionally active scFv

<400>  82

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser His Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  83
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 Y33E VH Conditionally active scFv

<400>  83

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  84
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VL Conditionally active scFv

<400>  84

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Arg Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L3 4 Conditionally active scFv


<220>
<221>  X is T, I, or P
<222>  (3)..(3)

<220>
<221>  X is E or V
<222>  (5)..(5)

<220>
<221>  X is F or T
<222>  (8)..(8)

<220>
<221>  X is F or T
<222>  (10)..(10)

<400>  85

Gln Gln Xaa Asn Xaa Asp Pro Xaa Thr Xaa 
1               5                   10  


<210>  86
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VL 5 Conditionally active scFv

<400>  86

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Arg Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Thr Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl H1 1 Conditionally active scFv


<220>
<221>  X is T or W
<222>  (1)..(1)

<220>
<221>  X is H or A
<222>  (3)..(3)

<400>  87

Xaa Gly Xaa Thr Met Asn 
1               5       


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl H2 1 Conditionally active scFv

<400>  88

Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl H31 Conditionally active scFv


<220>
<221>  X is H or D
<222>  (2)..(2)

<220>
<221>  X is E or H
<222>  (4)..(4)

<220>
<221>  X is E or F
<222>  (7)..(7)

<400>  89

Gly Xaa Tyr Xaa Ser Tyr Xaa Ala Met Asp Tyr 
1               5                   10      


<210>  90
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl L1 1 Conditionally active scFv


<220>
<221>  X is S or V
<222>  (7)..(7)

<400>  90

Lys Ala Ser Gln Asp Val Xaa Ser Ala Val Ala 
1               5                   10      


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl L2 1 Conditionally active scFv


<220>
<221>  X is A or Q
<222>  (2)..(2)

<220>
<221>  X is S or D
<222>  (3)..(3)

<220>
<221>  X is H or D
<222>  (6)..(6)

<400>  91

Trp Xaa Xaa Thr Arg Xaa Thr 
1               5           


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl L3 1 Conditionally active scFv


<220>
<221>  X is T or P
<222>  (6)..(6)

<220>
<221>  X is T or R
<222>  (9)..(9)

<400>  92

Gln Glu His Phe Ser Xaa Pro Leu Xaa 
1               5                   


<210>  93
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl WT VH Conditionally active scFv

<400>  93

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  94
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl WT VL Conditionally active scFv

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu His Phe Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H1 1 Conditionally active scFv


<220>
<221>  X is F or E
<222>  (4)..(4)

<220>
<221>  X is Y or D
<222>  (7)..(7)

<220>
<221>  X is M or D
<222>  (9)..(9)

<400>  95

Gly Tyr Thr Xaa Thr Glu Xaa Thr Xaa His 
1               5                   10  


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H1 2 Conditionally active scFv


<220>
<221>  X is T or S
<222>  (1)..(1)

<400>  96

Xaa Gly Tyr Ser Ile Thr Thr Gly Tyr Tyr Trp Asn 
1               5                   10          


<210>  97
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H1 2 Conditionally active scFv


<220>
<221>  X is E or I
<222>  (2)..(2)

<220>
<221>  X is T or D
<222>  (4)..(4)

<400>  97

Gly Xaa Asn Xaa Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H2 2 Conditionally active scFv

<400>  98

Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  99
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H3 1 Conditionally active scFv

<400>  99

Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr 
1               5                   10              


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H3 2 Conditionally active scFv


<220>
<221>  X is Y or G
<222>  (6)..(6)

<400>  100

Phe Glu Gly Val Trp Xaa Gly Leu Asp Tyr 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L1 1 Conditionally active scFv


<220>
<221>  X is E or V
<222>  (6)..(6)

<400>  101

Ser Ala Thr Ser Ser Xaa Ser Tyr Met His 
1               5                   10  


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L1 2 Conditionally active scFv

<400>  102

Arg Ala Ser Glu Ser Val Asp Arg Tyr Gly Asn Ser Phe Ile His 
1               5                   10                  15  


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L2 1 Conditionally active scFv


<220>
<221>  X is G or H
<222>  (1)..(1)

<400>  103

Xaa Thr Ser Asn Leu Ala Ser 
1               5           


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L2 2 Conditionally active scFv

<400>  104

Arg Thr Tyr Asn Leu Glu Ser 
1               5           


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L3 1 Conditionally active scFv

<400>  105

Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L3 2 Conditionally active scFv

<400>  106

Gln Gln Thr Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  107
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 WT VH Conditionally active scFv

<400>  107

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  108
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VL 1 Conditionally active scFv

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser 
    50                  55                  60  


<210>  109
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VL 2 Conditionally active scFv

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser 
    50                  55                  60  


<210>  110
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VL 3 Conditionally active scFv

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser 
    50                  55                  60  


<210>  111
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VL 4 Conditionally active scFv

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser 
    50                  55                  60  


<210>  112
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VH 1 Conditionally active scFv

<400>  112

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Thr Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  113
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VH 2 Conditionally active scFv

<400>  113

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  114
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl VH 3 Conditionally active scFv

<400>  114

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Thr Gly His 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  115
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 1 Conditionally active scFv

<400>  115

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Met Lys Gln Ser His Arg Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Thr Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  116
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 1 Conditionally active scFv

<400>  116

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Glu Thr Glu Asp 
            20                  25                  30          


Thr Asp His Trp Met Lys Gln Ser His Arg Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Glu Asn Asp Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala His Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  117
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 3 Conditionally active scFv

<400>  117

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Thr Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  118
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 4 Conditionally active scFv

<400>  118

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Thr Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  119
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 5 Conditionally active scFv

<400>  119

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Asn Thr Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  120
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 6 Conditionally active scFv

<400>  120

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Lys Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  121
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VH 7 Conditionally active scFv

<400>  121

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Ala Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Lys Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser His Phe Glu Gly Val Trp Gly Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  122
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VL 1 Conditionally active scFv

<400>  122

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  123
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VL 2 Conditionally active scFv

<400>  123

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Glu Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


His Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  124
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 VL 3 Conditionally active scFv

<400>  124

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  125
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic wild-type CD8  Stalk

<400>  125

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        35                  40              


<210>  126
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic wild-type CD28  Stalk

<400>  126

Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
1               5                   10                  15      


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            20                  25                  30          


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40          


<210>  127
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic CD3Z 7 Activating domain

<400>  127

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  128
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFv from F1-2-15

<400>  128

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
145                 150                 155                 160 


Gln Asp Val Val Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Arg Leu Leu Ile Tyr Trp Gln Asp Thr Arg His Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu 
    210                 215                 220                 


His Phe Ser Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  129
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFv from F1-2-13

<400>  129

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
145                 150                 155                 160 


Ser Gln Asp Val Val Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Trp Gln Asp Thr Arg His Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Glu His Phe Ser Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  130
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFv from F1-1-19

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu 
                165                 170                 175     


Ser Val Asp Arg Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu 
        195                 200                 205             


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Thr Asn Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys 
            260 


<210>  131
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFv from F1-1-23

<400>  131

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Arg Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
    130                 135                 140                 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly Glu Tyr Trp 
                165                 170                 175     


Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu Lys Asn Arg 
        195                 200                 205             


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
    210                 215                 220                 


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser Arg Phe 
225                 230                 235                 240 


Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  132
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-1-15

<400>  132

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Arg Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
    130                 135                 140                 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly Tyr Tyr Trp 
                165                 170                 175     


Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile Gly Tyr 
            180                 185                 190         


Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu Lys Asn Arg 
        195                 200                 205             


Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
    210                 215                 220                 


Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser His Phe 
225                 230                 235                 240 


Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  133
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic IC-delta CD137 Dual Co-stimulatory domain

<400>  133

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Ala Tyr Ala Ala 
            20                  25                  30          


Ala Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu 
            


<210>  134
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl H1 2 Conditionally active scFv


<220>
<221>  X is T, A, or W
<222>  (1)..(1)

<220>
<221>  X is H or A
<222>  (3)..(3)

<220>
<221>  X is T or I
<222>  (4)..(4)

<220>
<221>  X is N or I
<222>  (6)..(6)

<400>  134

Xaa Gly Xaa Xaa Met Xaa 
1               5       


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl H1 2 Conditionally active scFv


<220>
<221>  X is P or N
<222>  (4)..(4)

<220>
<221>  X is S, I, or T
<222>  (10)..(10)

<400>  135

Leu Ile Lys Xaa Ser Asn Gly Gly Thr Xaa Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl H3 2 Conditionally active scFv


<220>
<221>  X is H, D, E, P, R, or W
<222>  (2)..(2)

<220>
<221>  X is Y or N
<222>  (3)..(3)

<220>
<221>  X is E, A, D, F, G, H, I, L, M, N, R, V, or Y
<222>  (4)..(4)

<220>
<221>  X is S, D, M, N, or Q
<222>  (5)..(5)

<220>
<221>  X is Y, C, E, or P
<222>  (6)..(6)

<220>
<221>  X is F, E, N, S, T, or V
<222>  (7)..(7)

<220>
<221>  X is A, D, G, L, or Y
<222>  (8)..(8)

<220>
<221>  X is M, E, or F
<222>  (9)..(9)

<220>
<221>  X is W, A, D, H, L, N, P, R, or T
<222>  (12)..(12)

<220>
<221>  X is G or H
<222>  (13)..(13)

<400>  136

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Tyr Xaa Xaa 
1               5                   10              


<210>  137
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl L1 2 Conditionally active scFv


<220>
<221>  X is V, D, G, N, or W
<222>  (6)..(6)

<220>
<221>  X is S or V
<222>  (7)..(7)

<220>
<221>  X is A, L, or M
<222>  (9)..(9)

<220>
<221>  X is A, D, N, or Q
<222>  (11)..(11)

<400>  137

Lys Ala Ser Gln Asp Xaa Xaa Ser Xaa Val Xaa 
1               5                   10      


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl L2 2 Conditionally active scFv


<220>
<221>  X is W or F
<222>  (1)..(1)

<220>
<221>  X is A, I, N, P, or Q
<222>  (2)..(2)

<220>
<221>  X is S or D
<222>  (3)..(3)

<220>
<221>  X is H or D
<222>  (6)..(6)

<400>  138

Xaa Xaa Xaa Thr Arg Xaa Thr 
1               5           


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Axl L2 2 Conditionally active scFv


<220>
<221>  X is H, C, F, I, L, Q, S, T, V, or Y
<222>  (3)..(3)

<220>
<221>  X is F, C, D, E, G, N, or S
<222>  (4)..(4)

<220>
<221>  X is T, C, or P
<222>  (6)..(6)

<220>
<221>  X is P, A, C, D, E, H, K, S, T, V, or W
<222>  (7)..(7)

<220>
<221>  X is L, G, or R
<222>  (8)..(8)

<220>
<221>  X is T, I, or R
<222>  (9)..(9)

<400>  139

Gln Glu Xaa Xaa Ser Xaa Xaa Xaa Xaa 
1               5                   


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H1 3 Conditionally active scFv


<220>
<221>  X is F or E
<222>  (4)..(4)

<220>
<221>  X is Y or D
<222>  (7)..(7)

<220>
<221>  X is T or C
<222>  (8)..(8)

<220>
<221>  X is M, D, E, or Y
<222>  (9)..(9)

<400>  140

Gly Tyr Thr Xaa Thr Glu Xaa Xaa Xaa His 
1               5                   10  


<210>  141
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H1 4 Conditionally active scFv


<220>
<221>  X is Y, E, R, or T
<222>  (8)..(8)

<400>  141

Gly Tyr Ser Ile Thr Thr Gly Xaa Tyr Trp Asn 
1               5                   10      


<210>  142
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H2 3 Conditionally active scFv


<220>
<221>  X is G or S
<222>  (1)..(1)

<220>
<221>  X is I or E
<222>  (2)..(2)

<220>
<221>  X is N, C, L, or V
<222>  (3)..(3)

<220>
<221>  X is D or E
<222>  (4)..(4)

<220>
<221>  X is T, D, or E
<222>  (4)..(4)

<400>  142

Xaa Xaa Xaa Xaa Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H2 4 Conditionally active scFv


<220>
<221>  X is K or N
<222>  (8)..(8)

<400>  143

Tyr Ile Thr Tyr Asp Gly Ser Xaa Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H3 3 Conditionally active scFv


<220>
<221>  X is A, M, or T
<222>  (1)..(1)

<220>
<221>  X is R or H
<222>  (2)..(2)

<220>
<221>  X is G or E
<222>  (3)..(3)

<220>
<221>  X is L or F
<222>  (5)..(5)

<220>
<221>  X is S or G
<222>  (7)..(7)

<220>
<221>  X is G or D
<222>  (9)..(9)

<220>
<221>  X is N or E
<222>  (10)..(10)

<220>
<221>  X is D or L
<222>  (14)..(14)

<220>
<221>  X is Y, C, or T
<222>  (15)..(15)

<220>
<221>  X is W or L
<222>  (16)..(16)

<400>  144

Xaa Xaa Xaa Ser Xaa Tyr Xaa Tyr Xaa Xaa Ser Tyr Phe Xaa Xaa Xaa 
1               5                   10                  15      


<210>  145
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 H3 4 Conditionally active scFv


<220>
<221>  X is R, G, H, W, or Y
<222>  (3)..(3)

<220>
<221>  X is F, C, N, or Q
<222>  (4)..(4)

<220>
<221>  X is E or S
<222>  (5)..(5)

<220>
<221>  X is G, E, F, H, M, Q, or S
<222>  (6)..(6)

<220>
<221>  X is W, A, I, P, Q, T, or V
<222>  (8)..(8)

<220>
<221>  X is Y, G, N, or Q
<222>  (9)..(9)

<220>
<221>  X is G, S, or T
<222>  (10)..(10)

<220>
<221>  X is Y or I
<222>  (13)..(13)

<400>  145

Cys Ser Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Leu Asp Xaa 
1               5                   10              


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L1 3 Conditionally active scFv


<220>
<221>  X is V or E
<222>  (6)..(6)

<220>
<221>  X is S or D
<222>  (7)..(7)

<220>
<221>  X is Y, C, or D
<222>  (8)..(8)

<220>
<221>  X is H, G, or L
<222>  (10)..(10)

<400>  146

Ser Ala Thr Ser Ser Xaa Xaa Xaa Met Xaa 
1               5                   10  


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L1 4 Conditionally active scFv


<220>
<221>  X is F, S, or T
<222>  (13)..(13)

<400>  147

Arg Ala Ser Glu Ser Val Asp Arg Tyr Gly Asn Ser Xaa Ile His 
1               5                   10                  15  


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L2 3 Conditionally active scFv


<220>
<221>  X is G, C, H, or P
<222>  (1)..(1)

<400>  148

Xaa Thr Ser Asn Leu Ala Ser 
1               5           


<210>  149
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L2 4 Conditionally active scFv


<220>
<221>  X is R, C, D, E, or W
<222>  (1)..(1)

<220>
<221>  X is N or D
<222>  (4)..(4)

<400>  149

Xaa Thr Tyr Xaa Leu Glu Ser 
1               5           


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 L3 3 Conditionally active scFv


<220>
<221>  X is Q or E
<222>  (2)..(2)

<220>
<221>  X is R or H
<222>  (3)..(3)

<220>
<221>  X is S, D, G, I, Q, or V
<222>  (5)..(5)

<220>
<221>  X is T or D
<222>  (9)..(9)

<220>
<221>  X is F, D, or E
<222>  (10)..(10)

<400>  150

Gln Xaa Xaa Ser Xaa Tyr Pro Phe Xaa Xaa 
1               5                   10  


<210>  151
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 CAB3 VH

<400>  151

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Asn Asp Asn Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Leu Tyr Ser Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  152
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic Ror2 CAB VL

<400>  152

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
        35                  40                  45              


His Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg 
    50                  55                  60  


<210>  153
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-1-11

<400>  153

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser His Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu 
                165                 170                 175     


Ser Val Asp Arg Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys 
            180                 185                 190         


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu 
        195                 200                 205             


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
    210                 215                 220                 


Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Thr Asn Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     


Val Glu Ile Lys 
            260 


<210>  154
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-1-17

<400>  154

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Glu Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Glu Ser Val Asp Arg Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu 
            180                 185                 190         


Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Thr Asn Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  155
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-1-25

<400>  155

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
        35                  40                  45              


His Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser 
        115                 120                 125             


Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Ile Arg Gln 
145                 150                 155                 160 


Ser Pro Ser Arg Gly Leu Glu Trp Leu Gly Gly Ile Asn Asp Asn Asn 
                165                 170                 175     


Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Leu Tyr Ser 
    210                 215                 220                 


Tyr Gly Asn Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  156
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFv from F1-1-26

<400>  156

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
        35                  40                  45              


His Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Val Gly Val Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
    130                 135                 140                 


Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala 
145                 150                 155                 160 


Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Ile Arg Gln Ser 
                165                 170                 175     


Pro Ser Arg Gly Leu Glu Trp Leu Gly Gly Ile Asn Asp Asn Asn Gly 
            180                 185                 190         


Gly Thr Gly Tyr Asn Gln Lys Phe Lys Gly Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ser Leu Tyr Ser Tyr 
225                 230                 235                 240 


Gly Asn Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210>  157
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-1-9

<400>  157

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser His Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Glu Ser Val Asp Arg Tyr Gly Asn Ser Phe Ile His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu 
            180                 185                 190         


Glu Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Thr Asn Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  158
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-1-21

<400>  158

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Arg Tyr 
            20                  25                  30          


Gly Asn Ser Phe Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Thr Tyr Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr Leu 
    130                 135                 140                 


Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Thr Gly Glu Tyr 
145                 150                 155                 160 


Trp Asn Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Ile Gly 
                165                 170                 175     


Tyr Ile Thr Tyr Asp Gly Ser Lys Asn Tyr Asn Pro Ser Leu Lys Asn 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
    210                 215                 220                 


Phe Glu Gly Val Trp Tyr Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  159
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-2-3

<400>  159

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala 
            20                  25                  30          


Thr Met Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Lys Pro Ser Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly His Tyr Glu Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Val Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ala Pro Arg Leu Leu Ile Tyr Trp Gln Asp Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu 
225                 230                 235                 240 


His Phe Ser Pro Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys 
    


<210>  160
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-2-8

<400>  160

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu His Phe Ser Pro Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln 
        115                 120                 125             


Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser Cys 
    130                 135                 140                 


Lys Val Ser Gly Tyr Ser Phe Trp Gly Ala Thr Met Asn Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Leu Ile Lys Pro Ser 
                165                 170                 175     


Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile 
            180                 185                 190         


Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu 
        195                 200                 205             


Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala His Gly His Tyr Glu 
    210                 215                 220                 


Ser Tyr Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  161
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic scFV from F1-2-10

<400>  161

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Val Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Trp Gln Asp Thr Arg His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Glu His Phe Ser Pro Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Gln Ser 
    130                 135                 140                 


Gly Ala Glu Val Lys Lys Pro Gly Ala Thr Val Lys Ile Ser Cys Lys 
145                 150                 155                 160 


Val Ser Gly Tyr Ser Phe Trp Gly Ala Thr Met Asn Trp Ile Arg Gln 
                165                 170                 175     


Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Leu Ile Lys Pro Ser Asn 
            180                 185                 190         


Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Ser 
        195                 200                 205             


Ala Asp Lys Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys 
    210                 215                 220                 


Ala Ser Asp Thr Ala Met Tyr Tyr Cys Ala His Gly His Tyr Glu Ser 
225                 230                 235                 240 


Tyr Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                245                 250                 255     


Ser 
    


