                         SEQUENCE LISTING

<110>  Theripion, Inc.
 
<120>  Tandem ApoA-1 Fusion Polypeptides

<130>  TRP-0310PC

<150>  US 62/432,128
<151>  2016-12-09

<150>  US 62/467,288
<151>  2017-03-06

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  1602
<212>  DNA
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG DNA

<400>  1
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa tgataatcta ga                        1602


<210>  2
<211>  525
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG


<220>
<221>  SIGNAL
<222>  (1)..(18)

<400>  2

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 525 


<210>  3
<211>  2052
<212>  DNA
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1 DNA

<400>  3
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcccttcc ctgggcaagg aatcccgggc caagaaattc     1680

cagcggcagc atatggactc agacagttcc cccagcagca gctccaccta ctgtaaccaa     1740

atgatgaggc gccggaatat gacacagggg cggtgcaaac cagtgaacac ctttgtgcac     1800

gagcccctgg tagatgtcca gaatgtctgt ttccaggaaa aggtcacctg caagaacggg     1860

cagggcaact gctacaagag caactccagc atgcacatca cagactgccg cctgacaaac     1920

ggctccaggt accccaactg tgcataccgg accagcccga aggagagaca catcattgtg     1980

gcctgtgaag ggagcccata tgtgccagtc cactttgatg cttctgtgga ggactctacc     2040

taataatcta ga                                                         2052


<210>  4
<211>  675
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1

<400>  4

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Pro 
    530                 535                 540                 


Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met 
545                 550                 555                 560 


Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met 
                565                 570                 575     


Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr 
            580                 585                 590         


Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu 
        595                 600                 605             


Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser 
    610                 615                 620                 


Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro 
625                 630                 635                 640 


Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala 
                645                 650                 655     


Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu 
            660                 665                 670         


Asp Ser Thr 
        675 


<210>  5
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  5
aaggaatccc gggccaagaa attccagcgg cagcatatgg actcagacag ttcccccagc       60

agcagctcca cctactgtaa ccaaatgatg aggcgccgga atatgacaca ggggcggtgc      120

aaaccagtga acacctttgt gcacgagccc ctggtagatg tccagaatgt ctgtttccag      180

gaaaaggtca cctgcaagaa cgggcagggc aactgctaca agagcaactc cagcatgcac      240

atcacagact gccgcctgac aaacggctcc aggtacccca actgtgcata ccggaccagc      300

ccgaaggaga gacacatcat tgtggcctgt gaagggagcc catatgtgcc agtccacttt      360

gatgcttctg tggaggactc tacctaataa tctaga                                396


<210>  6
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp 
1               5                   10                  15      


Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg 
            20                  25                  30          


Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His 
        35                  40                  45              


Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr 
    50                  55                  60                  


Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His 
65                  70                  75                  80  


Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala 
                85                  90                  95      


Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly 
            100                 105                 110         


Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        115                 120                 125             


<210>  7
<211>  462
<212>  DNA
<213>  Artificial

<220>
<223>  3-NLG-WThRNase1 DNA

<400>  7
gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatcccttcc       60

ctgggcaagg aatcccgggc caagaaattc cagcggcagc atatggactc agacagttcc      120

cccagcagca gctccaccta ctgtaaccaa atgatgaggc gccggaatat gacacagggg      180

cggtgcaaac cagtgaacac ctttgtgcac gagcccctgg tagatgtcca gaatgtctgt      240

ttccaggaaa aggtcacctg caagaacggg cagggcaact gctacaagag caactccagc      300

atgcacatca cagactgccg cctgacaaac ggctccaggt accccaactg tgcataccgg      360

accagcccga aggagagaca catcattgtg gcctgtgaag ggagcccata tgtgccagtc      420

cactttgatg cttctgtgga ggactctacc taataatcta ga                         462


<210>  8
<211>  150
<212>  PRT
<213>  Artificial

<220>
<223>  3-NLG-WThRNase1

<400>  8

Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln 
1               5                   10                  15      


Asp Ile Pro Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg 
            20                  25                  30          


Gln His Met Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys 
        35                  40                  45              


Asn Gln Met Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro 
    50                  55                  60                  


Val Asn Thr Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys 
65                  70                  75                  80  


Phe Gln Glu Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys 
                85                  90                  95      


Ser Asn Ser Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser 
            100                 105                 110         


Arg Tyr Pro Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile 
        115                 120                 125             


Ile Val Ala Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala 
    130                 135                 140                 


Ser Val Glu Asp Ser Thr 
145                 150 


<210>  9
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  (g4s)5 linker DNA

<400>  9
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg gctcaggtgg       60

tggaggatct ggaggaggtg ggagtaccgg tctcgag                                97


<210>  10
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  (g4s)5 linker

<400>  10

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
            20                  25                  30          


<210>  11
<211>  1099
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttacaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctctaaca gaccgatttg     1080

cacccatgcc atagaaact                                                  1099


<210>  12
<211>  355
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(15)

<400>  12

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  13
<211>  525
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG with proline at Eu position 331 in Fc 
       region

<400>  13

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520                 525 


<210>  14
<211>  675
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1 with proline at Eu position 331 in 
       Fc region

<400>  14

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Pro 
    530                 535                 540                 


Ser Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met 
545                 550                 555                 560 


Asp Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met 
                565                 570                 575     


Met Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr 
            580                 585                 590         


Phe Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu 
        595                 600                 605             


Lys Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser 
    610                 615                 620                 


Ser Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro 
625                 630                 635                 640 


Asn Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala 
                645                 650                 655     


Cys Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu 
            660                 665                 670         


Asp Ser Thr 
        675 


<210>  15
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker

<400>  15

Gly Gly Gly Gly Ser 
1               5   


<210>  16
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sequencing primer

<400>  16
ggttttggca gtacatcaat gg                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  sequencing primer

<400>  17
ctattgtctt cccaatcctc cc                                                22


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  sequencing primer

<400>  18
accttgcact tgtactcctt                                                   20


<210>  19
<211>  1531
<212>  DNA
<213>  Artificial

<220>
<223>  THER0 DNA (apo A-1-(lnk2)-mthIgG; apo A-1-mthIgG)

<400>  19
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tcgagcccaa atcttctgac      840

aaaactcaca catctccacc gtccccagca cctgaactcc tgggaggatc gtcagtcttc      900

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      960

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1020

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     1080

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1140

aaggtctcca acaaagccct cccagcctcc atcgagaaaa ccatctccaa agccaaaggg     1200

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     1260

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1320

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1380

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1440

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1500

tctctctctc cgggtaaatg ataatctaga a                                    1531


<210>  20
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  THER0 polypeptide (apo A-1-(lnk2)-mthIgG; apo A-1-mthIgG)

<400>  20

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Glu Pro Lys 
            260                 265                 270         


Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu 
        275                 280                 285             


Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    290                 295                 300                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
305                 310                 315                 320 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                325                 330                 335     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            340                 345                 350         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        355                 360                 365             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
    370                 375                 380                 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
385                 390                 395                 400 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                405                 410                 415     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            420                 425                 430         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        435                 440                 445             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    450                 455                 460                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
465                 470                 475                 480 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                485                 490                 495     


Leu Ser Pro Gly Lys 
            500     


<210>  21
<211>  1573
<212>  DNA
<213>  Artificial

<220>
<223>  THER2 DNA (apo A-1-(lnk16)-mthIgG; apo A-1-(g4s)2-mthIgG)

<400>  21
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggaggaggtg ggagtaccgg tctcgagccc aaatcttctg acaaaactca cacatctcca      900

ccgtccccag cacctgaact cctgggagga tcgtcagtct tcctcttccc cccaaaaccc      960

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1020

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1080

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1140

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1200

ctcccagcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1260

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1320

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1380

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1440

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1500

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctctctctc tccgggtaaa     1560

tgataatcta gaa                                                        1573


<210>  22
<211>  515
<212>  PRT
<213>  Artificial

<220>
<223>  THER2 polypeptide (apo A-1-(lnk16)-mthIgG; apo A-1-(g4s)2-mthIgG)

<400>  22

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser 
        275                 280                 285             


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210>  23
<211>  1633
<212>  DNA
<213>  Artificial

<220>
<223>  THER6 DNA (apo A-1-(lnk36)-mthIgG; apo A-1-(g4s)6-mthIgG)

<400>  23
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctggagg aggtggtagt      900

ggaggtggag gttctaccgg tctcgagccc aaatcttctg acaaaactca cacatctcca      960

ccgtccccag cacctgaact cctgggagga tcgtcagtct tcctcttccc cccaaaaccc     1020

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1080

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1140

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1200

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1260

ctcccagcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1320

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1380

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1440

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1500

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1560

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctctctctc tccgggtaaa     1620

tgataatcta gaa                                                        1633


<210>  24
<211>  535
<212>  PRT
<213>  Artificial

<220>
<223>  THER6 polypeptide (apo A-1-(lnk36)-mthIgG; apo A-1-(g4s)6-mthIgG)

<400>  24

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu 
    290                 295                 300                 


Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro 
305                 310                 315                 320 


Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                325                 330                 335     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            340                 345                 350         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        355                 360                 365             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    370                 375                 380                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
385                 390                 395                 400 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                405                 410                 415     


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            420                 425                 430         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        435                 440                 445             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    450                 455                 460                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
465                 470                 475                 480 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                485                 490                 495     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            500                 505                 510         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        515                 520                 525             


Leu Ser Leu Ser Pro Gly Lys 
    530                 535 


<210>  25
<211>  1588
<212>  DNA
<213>  Artificial

<220>
<223>  THER3 DNA (apo A-1-(lnk21)-mthIgG; apo A-1-(g4s)3-mthIgG)

<400>  25
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctcaggtgg tggaggatct      840

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa      900

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc      960

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1020

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1080

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1140

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1200

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     1260

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1320

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1380

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1440

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1500

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     1560

ctctctccgg gtaaatgata atctagaa                                        1588


<210>  26
<211>  520
<212>  PRT
<213>  Artificial

<220>
<223>  THER3 polypeptide (apo A-1-(lnk21)-mthIgG; apo A-1-(g4s)3-mthIgG)

<400>  26

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
        275                 280                 285             


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala 
    290                 295                 300                 


Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro 
305                 310                 315                 320 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                325                 330                 335     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            340                 345                 350         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        355                 360                 365             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    370                 375                 380                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
385                 390                 395                 400 


Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                405                 410                 415     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            420                 425                 430         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        435                 440                 445             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    450                 455                 460                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
465                 470                 475                 480 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                485                 490                 495     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            500                 505                 510         


Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520 


<210>  27
<211>  2677
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PON1 DNA

<400>  27
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1680

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1740

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1800

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1860

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1920

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1980

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     2040

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     2100

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     2160

gacccctact tacaatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     2220

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     2280

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     2340

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     2400

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2460

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2520

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2580

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2640

cacaaagctc tttactgtga gctctaataa tctagaa                              2677


<210>  28
<211>  883
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PON1 polypeptide

<400>  28

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
    530                 535                 540                 


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
545                 550                 555                 560 


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
                565                 570                 575     


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
            580                 585                 590         


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
        595                 600                 605             


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
    610                 615                 620                 


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
625                 630                 635                 640 


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
                645                 650                 655     


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
            660                 665                 670         


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
        675                 680                 685             


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
    690                 695                 700                 


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
705                 710                 715                 720 


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
                725                 730                 735     


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
            740                 745                 750         


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
        755                 760                 765             


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
    770                 775                 780                 


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
785                 790                 795                 800 


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
                805                 810                 815     


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
            820                 825                 830         


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
        835                 840                 845             


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
    850                 855                 860                 


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Glu Leu 
            


<210>  29
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  29
atatacgggc tccaggctga acggctcggg ccacttacac accactgcct gataaccatg       60

ctggctgcca cagtcctgac cctggccctg ctgggcaatg cccatgcctg ctccaaaggc      120

acctcgcacg aggcaggcat cgtgtgccgc atcaccaagc ctgccctcct ggtgttgaac      180

cacgagactg ccaaggtgat ccagaccgcc ttccagcgag ccagctaccc agatatcacg      240

ggcgagaagg ccatgatgct ccttggccaa gtcaagtatg ggttgcacaa catccagatc      300

agccacttgt ccatcgccag cagccaggtg gagctggtgg aagccaagtc cattgatgtc      360

tccattcaga acgtgtctgt ggtcttcaag gggaccctga agtatggcta caccactgcc      420

tggtggctgg gtattgatca gtccattgac ttcgagatcg actctgccat tgacctccag      480

atcaacacac agctgacctg tgactctggt agagtgcgga ccgatgcccc tgactgctac      540

ctgtctttcc ataagctgct cctgcatctc caaggggagc gagagcctgg gtggatcaag      600

cagctgttca caaatttcat ctccttcacc ctgaagctgg tcctgaaggg acagatctgc      660

aaagagatca acgtcatctc taacatcatg gccgattttg tccagacaag ggctgccagc      720

atcctttcag atggagacat tggggtggac atttccctga caggtgatcc cgtcatcaca      780

gcctcctacc tggagtccca tcacaagggt catttcatct acaagaatgt ctcagaggac      840

ctccccctcc ccaccttctc gcccacactg ctgggggact cccgcatgct gtacttctgg      900

ttctctgagc gagtcttcca ctcgctggcc aaggtagctt tccaggatgg ccgcctcatg      960

ctcagcctga tgggagacga gttcaaggca gtgctggaga cctggggctt caacaccaac     1020

caggaaatct tccaagaggt tgtcggcggc ttccccagcc aggcccaagt caccgtccac     1080

tgcctcaaga tgcccaagat ctcctgccaa aacaagggag tcgtggtcaa ttcttcagtg     1140

atggtgaaat tcctctttcc acgcccagac cagcaacatt ctgtagctta cacatttgaa     1200

gaggatatcg tgactaccgt ccaggcctcc tattctaaga aaaagctctt cttaagcctc     1260

ttggatttcc agattacacc aaagactgtt tccaacttga ctgagagcag ctccgagtcc     1320

gtccagagct tcctgcagtc aatgatcacc gctgtgggca tccctgaggt catgtctcgg     1380

ctcgaggtag tgtttacagc cctcatgaac agcaaaggcg tgagcctctt cgacatcatc     1440

aaccctgaga ttatcactcg agatggcttc ctgctgctgc agatggactt tggcttccct     1500

gagcacctgc tggtggattt cctccagagc ttgagctaga agtctccaag gaggtcggga     1560

tggggcttgt agcagaaggc aagcaccagg ctcacagctg gaaccctggt gtctcctcca     1620

gcgtggtgga agttgggtta ggagtacgga gatggagatt ggctcccaac tcctccctat     1680

cctaaaggcc cactggcatt aaagtgctgt atccaag                              1717


<210>  30
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile 
            20                  25                  30          


Thr Lys Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile 
        35                  40                  45              


Gln Thr Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys 
    50                  55                  60                  


Ala Met Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln 
65                  70                  75                  80  


Ile Ser His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala 
                85                  90                  95      


Lys Ser Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly 
            100                 105                 110         


Thr Leu Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln 
        115                 120                 125             


Ser Ile Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr 
    130                 135                 140                 


Gln Leu Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys 
145                 150                 155                 160 


Tyr Leu Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu 
                165                 170                 175     


Pro Gly Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu 
            180                 185                 190         


Lys Leu Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser 
        195                 200                 205             


Asn Ile Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser 
    210                 215                 220                 


Asp Gly Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile 
225                 230                 235                 240 


Thr Ala Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys 
                245                 250                 255     


Asn Val Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu 
            260                 265                 270         


Gly Asp Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His 
        275                 280                 285             


Ser Leu Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu 
    290                 295                 300                 


Met Gly Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr 
305                 310                 315                 320 


Asn Gln Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala 
                325                 330                 335     


Gln Val Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn 
            340                 345                 350         


Lys Gly Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro 
        355                 360                 365             


Arg Pro Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile 
    370                 375                 380                 


Val Thr Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser 
385                 390                 395                 400 


Leu Leu Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu 
                405                 410                 415     


Ser Ser Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala 
            420                 425                 430         


Val Gly Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala 
        435                 440                 445             


Leu Met Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu 
    450                 455                 460                 


Ile Ile Thr Arg Asp Gly Phe Leu Leu Leu Gln Met Asp Phe Gly Phe 
465                 470                 475                 480 


Pro Glu His Leu Leu Val Asp Phe Leu Gln Ser Leu Ser 
                485                 490             


<210>  31
<211>  1880
<212>  DNA
<213>  Homo sapiens

<400>  31
gggtcggggc cacaaggccg cgctaggcgg acccaggaca cagcccgcgc gcagcccacc       60

cgcccgccgc ctgccagagc tgctcggccc gcagccaggg ggacagcggc tggtcggagg      120

ctcgcagtgc tgtcggcgag aagcagtcgg gtttggagcg cttgggtcgc gttggtgcgc      180

ggtggaacgc gcccagggac cccagttccc gcgagcagct ccgcgccgcg cctgagagac      240

taagctgaaa ctgctgctca gctcccaaga tggtgccacc caaattgcat gtgcttttct      300

gcctctgcgg ctgcctggct gtggtttatc cttttgactg gcaatacata aatcctgttg      360

cccatatgaa atcatcagca tgggtcaaca aaatacaagt actgatggct gctgcaagct      420

ttggccaaac taaaatcccc cggggaaatg ggccttattc cgttggttgt acagacttaa      480

tgtttgatca cactaataag ggcaccttct tgcgtttata ttatccatcc caagataatg      540

atcgccttga caccctttgg atcccaaata aagaatattt ttggggtctt agcaaatttc      600

ttggaacaca ctggcttatg ggcaacattt tgaggttact ctttggttca atgacaactc      660

ctgcaaactg gaattcccct ctgaggcctg gtgaaaaata tccacttgtt gttttttctc      720

atggtcttgg ggcattcagg acactttatt ctgctattgg cattgacctg gcatctcatg      780

ggtttatagt tgctgctgta gaacacagag atagatctgc atctgcaact tactatttca      840

aggaccaatc tgctgcagaa ataggggaca agtcttggct ctaccttaga accctgaaac      900

aagaggagga gacacatata cgaaatgagc aggtacggca aagagcaaaa gaatgttccc      960

aagctctcag tctgattctt gacattgatc atggaaagcc agtgaagaat gcattagatt     1020

taaagtttga tatggaacaa ctgaaggact ctattgatag ggaaaaaata gcagtaattg     1080

gacattcttt tggtggagca acggttattc agactcttag tgaagatcag agattcagat     1140

gtggtattgc cctggatgca tggatgtttc cactgggtga tgaagtatat tccagaattc     1200

ctcagcccct cttttttatc aactctgaat atttccaata tcctgctaat atcataaaaa     1260

tgaaaaaatg ctactcacct gataaagaaa gaaagatgat tacaatcagg ggttcagtcc     1320

accagaattt tgctgacttc acttttgcaa ctggcaaaat aattggacac atgctcaaat     1380

taaagggaga catagattca aatgtagcta ttgatcttag caacaaagct tcattagcat     1440

tcttacaaaa gcatttagga cttcataaag attttgatca gtgggactgc ttgattgaag     1500

gagatgatga gaatcttatt ccagggacca acattaacac aaccaatcaa cacatcatgt     1560

tacagaactc ttcaggaata gagaaataca attaggatta aaataggttt tttaaaagtc     1620

ttgtttcaaa actgtctaaa attatgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgagag     1680

agagagagag agagagagag agagagagag agaattttaa tgtattttcc caaaggactc     1740

atattttaaa atgtaggcta tactgtaatc gtgattgaag cttggactaa gaattttttc     1800

cctttagatg taaagaaaga atacagtata caatattcaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa                                                 1880


<210>  32
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  33
<211>  2907
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PAFAH DNA

<400>  33
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatctttgac tggcaataca taaatcctgt tgcccatatg     1680

aaatcatcag catgggtcaa caaaatacaa gtactgatgg ctgctgcaag ctttggccaa     1740

actaaaatcc cccggggaaa tgggccttat tccgttggtt gtacagactt aatgtttgat     1800

cacactaata agggcacctt cttgcgttta tattatccat cccaagataa tgatcgcctt     1860

gacacccttt ggatcccaaa taaagaatat ttttggggtc ttagcaaatt tcttggaaca     1920

cactggctta tgggcaacat tttgaggtta ctctttggtt caatgacaac tcctgcaaac     1980

tggaattccc ctctgaggcc tggtgaaaaa tatccacttg ttgttttttc tcatggtctt     2040

ggggcattca ggacacttta ttctgctatt ggcattgacc tggcatctca tgggtttata     2100

gttgctgctg tagaacacag agatagatct gcatctgcaa cttactattt caaggaccaa     2160

tctgctgcag aaatagggga caagtcttgg ctctacctta gaaccctgaa acaagaggag     2220

gagacacata tacgaaatga gcaggtacgg caaagagcaa aagaatgttc ccaagctctc     2280

agtctgattc ttgacattga tcatggaaag ccagtgaaga atgcattaga tttaaagttt     2340

gatatggaac aactgaagga ctctattgat agggaaaaaa tagcagtaat tggacattct     2400

tttggtggag caacggttat tcagactctt agtgaagatc agagattcag atgtggtatt     2460

gccctggatg catggatgtt tccactgggt gatgaagtat attccagaat tcctcagccc     2520

ctctttttta tcaactctga atatttccaa tatcctgcta atatcataaa aatgaaaaaa     2580

tgctactcac ctgataaaga aagaaagatg attacaatca ggggttcagt ccaccagaat     2640

tttgctgact tcacttttgc aactggcaaa ataattggac acatgctcaa attaaaggga     2700

gacatagatt caaatgtagc tattgatctt agcaacaaag cttcattagc attcttacaa     2760

aagcatttag gacttcataa agattttgat cagtgggact gcttgattga aggagatgat     2820

gagaatctta ttccagggac caacattaac acaaccaatc aacacatcat gttacagaac     2880

tcttcaggaa tagagaaata caattag                                         2907


<210>  34
<211>  963
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PAFAH polypeptide

<400>  34

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Phe 
    530                 535                 540                 


Asp Trp Gln Tyr Ile Asn Pro Val Ala His Met Lys Ser Ser Ala Trp 
545                 550                 555                 560 


Val Asn Lys Ile Gln Val Leu Met Ala Ala Ala Ser Phe Gly Gln Thr 
                565                 570                 575     


Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser Val Gly Cys Thr Asp Leu 
            580                 585                 590         


Met Phe Asp His Thr Asn Lys Gly Thr Phe Leu Arg Leu Tyr Tyr Pro 
        595                 600                 605             


Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu Trp Ile Pro Asn Lys Glu 
    610                 615                 620                 


Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly Thr His Trp Leu Met Gly 
625                 630                 635                 640 


Asn Ile Leu Arg Leu Leu Phe Gly Ser Met Thr Thr Pro Ala Asn Trp 
                645                 650                 655     


Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr Pro Leu Val Val Phe Ser 
            660                 665                 670         


His Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Ile Gly Ile Asp 
        675                 680                 685             


Leu Ala Ser His Gly Phe Ile Val Ala Ala Val Glu His Arg Asp Arg 
    690                 695                 700                 


Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp Gln Ser Ala Ala Glu Ile 
705                 710                 715                 720 


Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr Leu Lys Gln Glu Glu Glu 
                725                 730                 735     


Thr His Ile Arg Asn Glu Gln Val Arg Gln Arg Ala Lys Glu Cys Ser 
            740                 745                 750         


Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp His Gly Lys Pro Val Lys 
        755                 760                 765             


Asn Ala Leu Asp Leu Lys Phe Asp Met Glu Gln Leu Lys Asp Ser Ile 
    770                 775                 780                 


Asp Arg Glu Lys Ile Ala Val Ile Gly His Ser Phe Gly Gly Ala Thr 
785                 790                 795                 800 


Val Ile Gln Thr Leu Ser Glu Asp Gln Arg Phe Arg Cys Gly Ile Ala 
                805                 810                 815     


Leu Asp Ala Trp Met Phe Pro Leu Gly Asp Glu Val Tyr Ser Arg Ile 
            820                 825                 830         


Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu Tyr Phe Gln Tyr Pro Ala 
        835                 840                 845             


Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser Pro Asp Lys Glu Arg Lys 
    850                 855                 860                 


Met Ile Thr Ile Arg Gly Ser Val His Gln Asn Phe Ala Asp Phe Thr 
865                 870                 875                 880 


Phe Ala Thr Gly Lys Ile Ile Gly His Met Leu Lys Leu Lys Gly Asp 
                885                 890                 895     


Ile Asp Ser Asn Val Ala Ile Asp Leu Ser Asn Lys Ala Ser Leu Ala 
            900                 905                 910         


Phe Leu Gln Lys His Leu Gly Leu His Lys Asp Phe Asp Gln Trp Asp 
        915                 920                 925             


Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu Ile Pro Gly Thr Asn Ile 
    930                 935                 940                 


Asn Thr Thr Asn Gln His Ile Met Leu Gln Asn Ser Ser Gly Ile Glu 
945                 950                 955                 960 


Lys Tyr Asn 
            


<210>  35
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  35
atgaaagctg cggtgctgac cttggccgtg ctcttcctga cggggagcca ggctcggcat       60

ttctggcagc aagatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      120

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      180

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc      240

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa      300

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag      360

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc      420

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag      480

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg      540

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg      600

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc      660

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa      720

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac      780

actaagaagc tcaacaccca a                                                801


<210>  36
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  37
<211>  2647
<212>  DNA
<213>  Artificial

<220>
<223>  THER2PON1 DNA

<400>  37
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggaggaggtg ggagtaccgg tctcgagccc aaatcttctg acaaaactca cacatctcca      900

ccgtccccag cacctgaact cctgggagga tcgtcagtct tcctcttccc cccaaaaccc      960

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1020

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1080

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1140

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1200

ctcccagcct ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1260

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1320

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1380

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac     1440

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1500

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctctctctc tccgggtaaa     1560

gtcgacggag ctagcagccc cgtgaacgtg agcagcccca gcgtgcagga tatcctcttc     1620

aggaaccacc agtcttctta ccaaacacga cttaatgctc tccgagaggt acaacccgta     1680

gaacttccta actgtaattt agttaaagga atcgaaactg gctctgaaga cttggagata     1740

ctgcctaatg gactggcttt cattagctct ggattaaagt atcctggaat aaagagcttc     1800

aaccccaaca gtcctggaaa aatacttctg atggacctga atgaagaaga tccaacagtg     1860

ttggaattgg ggatcactgg aagtaaattt gatgtatctt catttaaccc tcatgggatt     1920

agcacattca cagatgaaga taatgccatg tacctcctgg tggtgaacca tccagatgcc     1980

aagtccacag tggagttgtt taaatttcaa gaagaagaaa aatcgctttt gcatctaaaa     2040

accatcagac ataaacttct gcctaatttg aatgatattg ttgctgtggg acctgagcac     2100

ttttatggca caaatgatca ctattttctt gacccctact tacaatcctg ggagatgtat     2160

ttgggtttag cgtggtcgta tgttgtctac tatagtccaa gtgaagttcg agtggtggca     2220

gaaggatttg attttgctaa tggaatcaac atttcacccg atggcaagta tgtctatata     2280

gctgagttgc tggctcataa gattcatgtg tatgaaaagc atgctaattg gactttaact     2340

ccattgaagt cccttgactt taataccctc gtggataaca tatctgtgga tcctgagaca     2400

ggagaccttt gggttggatg ccatcccaat ggcatgaaaa tcttcttcta tgactcagag     2460

aatcctcctg catcagaggt gcttcgaatc cagaacattc taacagaaga acctaaagtg     2520

acacaggttt atgcagaaaa tggcacagtg ttgcaaggca gtacagttgc ctctgtgtac     2580

aaagggaaac tgctgattgg cacagtgttt cacaaagctc tttactgtga gctctaataa     2640

tctagaa                                                               2647


<210>  38
<211>  873
<212>  PRT
<213>  Artificial

<220>
<223>  THER2PON1 polypeptide

<400>  38

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser 
        275                 280                 285             


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys Val Asp Gly Ala Ser Ser Pro Val Asn Val Ser Ser Pro 
        515                 520                 525             


Ser Val Gln Asp Ile Leu Phe Arg Asn His Gln Ser Ser Tyr Gln Thr 
    530                 535                 540                 


Arg Leu Asn Ala Leu Arg Glu Val Gln Pro Val Glu Leu Pro Asn Cys 
545                 550                 555                 560 


Asn Leu Val Lys Gly Ile Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu 
                565                 570                 575     


Pro Asn Gly Leu Ala Phe Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile 
            580                 585                 590         


Lys Ser Phe Asn Pro Asn Ser Pro Gly Lys Ile Leu Leu Met Asp Leu 
        595                 600                 605             


Asn Glu Glu Asp Pro Thr Val Leu Glu Leu Gly Ile Thr Gly Ser Lys 
    610                 615                 620                 


Phe Asp Val Ser Ser Phe Asn Pro His Gly Ile Ser Thr Phe Thr Asp 
625                 630                 635                 640 


Glu Asp Asn Ala Met Tyr Leu Leu Val Val Asn His Pro Asp Ala Lys 
                645                 650                 655     


Ser Thr Val Glu Leu Phe Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu 
            660                 665                 670         


His Leu Lys Thr Ile Arg His Lys Leu Leu Pro Asn Leu Asn Asp Ile 
        675                 680                 685             


Val Ala Val Gly Pro Glu His Phe Tyr Gly Thr Asn Asp His Tyr Phe 
    690                 695                 700                 


Leu Asp Pro Tyr Leu Gln Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp 
705                 710                 715                 720 


Ser Tyr Val Val Tyr Tyr Ser Pro Ser Glu Val Arg Val Val Ala Glu 
                725                 730                 735     


Gly Phe Asp Phe Ala Asn Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr 
            740                 745                 750         


Val Tyr Ile Ala Glu Leu Leu Ala His Lys Ile His Val Tyr Glu Lys 
        755                 760                 765             


His Ala Asn Trp Thr Leu Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr 
    770                 775                 780                 


Leu Val Asp Asn Ile Ser Val Asp Pro Glu Thr Gly Asp Leu Trp Val 
785                 790                 795                 800 


Gly Cys His Pro Asn Gly Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn 
                805                 810                 815     


Pro Pro Ala Ser Glu Val Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu 
            820                 825                 830         


Pro Lys Val Thr Gln Val Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly 
        835                 840                 845             


Ser Thr Val Ala Ser Val Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val 
    850                 855                 860                 


Phe His Lys Ala Leu Tyr Cys Glu Leu 
865                 870             


<210>  39
<211>  3084
<212>  DNA
<213>  Artificial

<220>
<223>  THER4CETP DNA

<400>  39
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatctgctcc aaaggcacct cgcacgaggc aggcatcgtg     1680

tgccgcatca ccaagcctgc cctcctggtg ttgaaccacg agactgccaa ggtgatccag     1740

accgccttcc agcgagccag ctacccagat atcacgggcg agaaggccat gatgctcctt     1800

ggccaagtca agtatgggtt gcacaacatc cagatcagcc acttgtccat cgccagcagc     1860

caggtggagc tggtggaagc caagtccatt gatgtctcca ttcagaacgt gtctgtggtc     1920

ttcaagggga ccctgaagta tggctacacc actgcctggt ggctgggtat tgatcagtcc     1980

attgacttcg agatcgactc tgccattgac ctccagatca acacacagct gacctgtgac     2040

tctggtagag tgcggaccga tgcccctgac tgctacctgt ctttccataa gctgctcctg     2100

catctccaag gggagcgaga gcctgggtgg atcaagcagc tgttcacaaa tttcatctcc     2160

ttcaccctga agctggtcct gaagggacag atctgcaaag agatcaacgt catctctaac     2220

atcatggccg attttgtcca gacaagggct gccagcatcc tttcagatgg agacattggg     2280

gtggacattt ccctgacagg tgatcccgtc atcacagcct cctacctgga gtcccatcac     2340

aagggtcatt tcatctacaa gaatgtctca gaggacctcc ccctccccac cttctcgccc     2400

acactgctgg gggactcccg catgctgtac ttctggttct ctgagcgagt cttccactcg     2460

ctggccaagg tagctttcca ggatggccgc ctcatgctca gcctgatggg agacgagttc     2520

aaggcagtgc tggagacctg gggcttcaac accaaccagg aaatcttcca agaggttgtc     2580

ggcggcttcc ccagccaggc ccaagtcacc gtccactgcc tcaagatgcc caagatctcc     2640

tgccaaaaca agggagtcgt ggtcaattct tcagtgatgg tgaaattcct ctttccacgc     2700

ccagaccagc aacattctgt agcttacaca tttgaagagg atatcgtgac taccgtccag     2760

gcctcctatt ctaagaaaaa gctcttctta agcctcttgg atttccagat tacaccaaag     2820

actgtttcca acttgactga gagcagctcc gagtccgtcc agagcttcct gcagtcaatg     2880

atcaccgctg tgggcatccc tgaggtcatg tctcggctcg aggtagtgtt tacagccctc     2940

atgaacagca aaggcgtgag cctcttcgac atcatcaacc ctgagattat cactcgagat     3000

ggcttcctgc tgctgcagat ggactttggc ttccctgagc acctgctggt ggatttcctc     3060

cagagcttga gctaataatc taga                                            3084


<210>  40
<211>  1019
<212>  PRT
<213>  Artificial

<220>
<223>  THER4CETP polypeptide

<400>  40

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Cys 
    530                 535                 540                 


Ser Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile Thr Lys 
545                 550                 555                 560 


Pro Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile Gln Thr 
                565                 570                 575     


Ala Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys Ala Met 
            580                 585                 590         


Met Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln Ile Ser 
        595                 600                 605             


His Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala Lys Ser 
    610                 615                 620                 


Ile Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly Thr Leu 
625                 630                 635                 640 


Lys Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln Ser Ile 
                645                 650                 655     


Asp Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr Gln Leu 
            660                 665                 670         


Thr Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys Tyr Leu 
        675                 680                 685             


Ser Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu Pro Gly 
    690                 695                 700                 


Trp Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu Lys Leu 
705                 710                 715                 720 


Val Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser Asn Ile 
                725                 730                 735     


Met Ala Asp Phe Val Gln Thr Arg Ala Ala Ser Ile Leu Ser Asp Gly 
            740                 745                 750         


Asp Ile Gly Val Asp Ile Ser Leu Thr Gly Asp Pro Val Ile Thr Ala 
        755                 760                 765             


Ser Tyr Leu Glu Ser His His Lys Gly His Phe Ile Tyr Lys Asn Val 
    770                 775                 780                 


Ser Glu Asp Leu Pro Leu Pro Thr Phe Ser Pro Thr Leu Leu Gly Asp 
785                 790                 795                 800 


Ser Arg Met Leu Tyr Phe Trp Phe Ser Glu Arg Val Phe His Ser Leu 
                805                 810                 815     


Ala Lys Val Ala Phe Gln Asp Gly Arg Leu Met Leu Ser Leu Met Gly 
            820                 825                 830         


Asp Glu Phe Lys Ala Val Leu Glu Thr Trp Gly Phe Asn Thr Asn Gln 
        835                 840                 845             


Glu Ile Phe Gln Glu Val Val Gly Gly Phe Pro Ser Gln Ala Gln Val 
    850                 855                 860                 


Thr Val His Cys Leu Lys Met Pro Lys Ile Ser Cys Gln Asn Lys Gly 
865                 870                 875                 880 


Val Val Val Asn Ser Ser Val Met Val Lys Phe Leu Phe Pro Arg Pro 
                885                 890                 895     


Asp Gln Gln His Ser Val Ala Tyr Thr Phe Glu Glu Asp Ile Val Thr 
            900                 905                 910         


Thr Val Gln Ala Ser Tyr Ser Lys Lys Lys Leu Phe Leu Ser Leu Leu 
        915                 920                 925             


Asp Phe Gln Ile Thr Pro Lys Thr Val Ser Asn Leu Thr Glu Ser Ser 
    930                 935                 940                 


Ser Glu Ser Val Gln Ser Phe Leu Gln Ser Met Ile Thr Ala Val Gly 
945                 950                 955                 960 


Ile Pro Glu Val Met Ser Arg Leu Glu Val Val Phe Thr Ala Leu Met 
                965                 970                 975     


Asn Ser Lys Gly Val Ser Leu Phe Asp Ile Ile Asn Pro Glu Ile Ile 
            980                 985                 990         


Thr Arg Asp Gly Phe Leu Leu Leu  Gln Met Asp Phe Gly  Phe Pro Glu 
        995                 1000                 1005             


His Leu  Leu Val Asp Phe Leu  Gln Ser Leu Ser 
    1010                 1015                 


<210>  41
<211>  1068
<212>  DNA
<213>  Artificial

<220>
<223>  human PON1 Q192K DNA

<400>  41
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaaaatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctctaa                  1068


<210>  42
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  human PON1 Q192K polypeptide

<400>  42

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  43
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  43
atggcgaagc tgattgcgct caccctcttg gggatgggac tggcactctt caggaaccac       60

cagtcttctt accaaacacg acttaatgct ctccgagagg tacaacccgt agaacttcct      120

aactgtaatt tagttaaagg aatcgaaact ggctctgaag acttggagat actgcctaat      180

ggactggctt tcattagctc tggattaaag tatcctggaa taaagagctt caaccccaac      240

agtcctggaa aaatacttct gatggacctg aatgaagaag atccaacagt gttggaattg      300

gggatcactg gaagtaaatt tgatgtatct tcatttaacc ctcatgggat tagcacattc      360

acagatgaag ataatgccat gtacctcctg gtggtgaacc atccagatgc caagtccaca      420

gtggagttgt ttaaatttca agaagaagaa aaatcgcttt tgcatctaaa aaccatcaga      480

cataaacttc tgcctaattt gaatgatatt gttgctgtgg gacctgagca cttttatggc      540

acaaatgatc actattttct tgacccctac ttaagatcct gggagatgta tttgggttta      600

gcgtggtcgt atgttgtcta ctatagtcca agtgaagttc gagtggtggc agaaggattt      660

gattttgcta atggaatcaa catttcaccc gatggcaagt atgtctatat agctgagttg      720

ctggctcata agattcatgt gtatgaaaag catgctaatt ggactttaac tccattgaag      780

tcccttgact ttaataccct cgtggataac atatctgtgg atcctgagac aggagacctt      840

tgggttggat gccatcccaa tggcatgaaa atcttcttct atgactcaga gaatcctcct      900

gcatcagagg tgcttcgaat ccagaacatt ctaacagaag aacctaaagt gacacaggtt      960

tatgcagaaa atggcacagt gttgcaaggc agtacagttg cctctgtgta caaagggaaa     1020

ctgctgattg gcacagtgtt tcacaaagct ctttactgtg agctc                     1065


<210>  44
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Arg 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210>  45
<211>  2677
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PON1 Q192K DNA

<400>  45
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1680

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1740

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1800

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1860

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1920

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1980

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     2040

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     2100

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     2160

gacccctact taaaatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     2220

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     2280

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     2340

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     2400

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2460

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2520

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2580

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2640

cacaaagctc tttactgtga gctctaataa tctagaa                              2677


<210>  46
<211>  883
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PON1 Q192K polypeptide

<400>  46

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
    530                 535                 540                 


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
545                 550                 555                 560 


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
                565                 570                 575     


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
            580                 585                 590         


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
        595                 600                 605             


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
    610                 615                 620                 


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
625                 630                 635                 640 


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
                645                 650                 655     


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
            660                 665                 670         


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
        675                 680                 685             


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
    690                 695                 700                 


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys 
705                 710                 715                 720 


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
                725                 730                 735     


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
            740                 745                 750         


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
        755                 760                 765             


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
    770                 775                 780                 


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
785                 790                 795                 800 


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
                805                 810                 815     


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
            820                 825                 830         


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
        835                 840                 845             


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
    850                 855                 860                 


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Glu Leu 
            


<210>  47
<211>  2677
<212>  DNA
<213>  Artificial

<220>
<223>  THER4PON1 Q192R DNA

<400>  47
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcctcttc aggaaccacc agtcttctta ccaaacacga     1680

cttaatgctc tccgagaggt acaacccgta gaacttccta actgtaattt agttaaagga     1740

atcgaaactg gctctgaaga cttggagata ctgcctaatg gactggcttt cattagctct     1800

ggattaaagt atcctggaat aaagagcttc aaccccaaca gtcctggaaa aatacttctg     1860

atggacctga atgaagaaga tccaacagtg ttggaattgg ggatcactgg aagtaaattt     1920

gatgtatctt catttaaccc tcatgggatt agcacattca cagatgaaga taatgccatg     1980

tacctcctgg tggtgaacca tccagatgcc aagtccacag tggagttgtt taaatttcaa     2040

gaagaagaaa aatcgctttt gcatctaaaa accatcagac ataaacttct gcctaatttg     2100

aatgatattg ttgctgtggg acctgagcac ttttatggca caaatgatca ctattttctt     2160

gacccctact taagatcctg ggagatgtat ttgggtttag cgtggtcgta tgttgtctac     2220

tatagtccaa gtgaagttcg agtggtggca gaaggatttg attttgctaa tggaatcaac     2280

atttcacccg atggcaagta tgtctatata gctgagttgc tggctcataa gattcatgtg     2340

tatgaaaagc atgctaattg gactttaact ccattgaagt cccttgactt taataccctc     2400

gtggataaca tatctgtgga tcctgagaca ggagaccttt gggttggatg ccatcccaat     2460

ggcatgaaaa tcttcttcta tgactcagag aatcctcctg catcagaggt gcttcgaatc     2520

cagaacattc taacagaaga acctaaagtg acacaggttt atgcagaaaa tggcacagtg     2580

ttgcaaggca gtacagttgc ctctgtgtac aaagggaaac tgctgattgg cacagtgttt     2640

cacaaagctc tttactgtga gctctaataa tctagaa                              2677


<210>  48
<211>  883
<212>  PRT
<213>  Artificial

<220>
<223>  THER4PON1 Q192R polypeptide

<400>  48

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu 
    530                 535                 540                 


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
545                 550                 555                 560 


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
                565                 570                 575     


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
            580                 585                 590         


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
        595                 600                 605             


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
    610                 615                 620                 


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
625                 630                 635                 640 


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
                645                 650                 655     


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
            660                 665                 670         


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
        675                 680                 685             


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
    690                 695                 700                 


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Arg 
705                 710                 715                 720 


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
                725                 730                 735     


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
            740                 745                 750         


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
        755                 760                 765             


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
    770                 775                 780                 


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
785                 790                 795                 800 


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
                805                 810                 815     


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
            820                 825                 830         


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
        835                 840                 845             


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
    850                 855                 860                 


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
865                 870                 875                 880 


Cys Glu Leu 
            


<210>  49
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  (gly4ser)4 linker DNA

<400>  49
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct accggtctcg ag                                                82


<210>  50
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  (gly4ser)4 linker

<400>  50

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
            20                  25      


<210>  51
<211>  112
<212>  DNA
<213>  Artificial

<220>
<223>  (gly4ser)6 linker DNA

<400>  51
agatctctcc ggaggaggtg gctcaggtgg tggaggatct ggaggaggtg ggagtggtgg       60

aggtggttct ggaggaggtg gtagtggagg tggaggttct accggtctcg ag              112


<210>  52
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  (gly4ser)6 linker

<400>  52

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Thr Gly Leu 
        35      


<210>  53
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  (gly4ser)5 linker DNA

<400>  53
gatctctccg gaggaggtgg ctcaggtggt ggaggatctg gaggaggtgg gagtggtgga       60

ggtggttctg gaggaggtgg tagtaccggt ctc                                    93


<210>  54
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  (gly4ser)5 linker

<400>  54

Asp Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu 
            20                  25                  30      


<210>  55
<211>  2368
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc DNA

<400>  55
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaatgata atctagaa                                        2368


<210>  56
<211>  780
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apo A1-L2-Fc polypeptide

<400>  56

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780 


<210>  57
<211>  2368
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc DNA

<400>  57
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ctggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaatgata atctagaa                                        2368


<210>  58
<211>  780
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc polypeptide

<400>  58

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Pro Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780 


<210>  59
<211>  2258
<212>  DNA
<213>  Homo sapiens

<300>
<308>  A06977.1
<309>  1993-08-31
<313>  (76)..(1902)

<400>  59
aggatgtctt ctggcaattt catataagta ttttttcaaa aatgtctctt ctgtcaaccc       60

cacgcctttg gcacaatgaa gtgggtaacc tttatttccc ttctttttct ctttagctcg      120

gcttattcca ggggtgtgtt tcgtcgagat gcacacaaga gtgaggttgc tcatcggttt      180

aaagatttgg gagaagaaaa tttcaaagcc ttggtgttga ttgcctttgc tcagtatctt      240

cagcagtgtc catttgaaga tcatgtaaaa ttagtgaatg aagtaactga atttgcaaaa      300

acatgtgtag ctgatgagtc agctgaaaat tgtgacaaat cacttcatac cctttttgga      360

gacaaattat gcacagttgc aactcttcgt gaaacctatg gtgaaatggc tgactgctgt      420

gcaaaacaag aacctgagag aaatgaatgc ttcttgcaac acaaagatga caacccaaac      480

ctcccccgat tggtcagacc agaggttgat gtgatgtgca ctgcttttca tgacaatgaa      540

gagacatttt tgaaaaaata cttatatgaa attgccagaa gacatcctta cttttatgcc      600

ccggaactcc ttttctttgc taaaaggtat aaagctgctt ttacagaatg ttgccaagct      660

gctgataaag ctgcctgcct gttgccaaag ctcgatgaac ttcgggatga agggaaggct      720

tcgtctgcca aacagagact caaatgtgcc agtctccaaa aatttggaga aagagctttc      780

aaagcatggg cagtggctcg cctgagccag agatttccca aagctgagtt tgcagaagtt      840

tccaagttag tgacagatct taccaaagtc cacacggaat gctgccatgg agatctgctt      900

gaatgtgctg atgacagggc ggaccttgcc aagtatatct gtgaaaatca ggattcgatc      960

tccagtaaac tgaaggaatg ctgtgaaaaa cctctgttgg aaaaatccca ctgcattgcc     1020

gaagtggaaa atgatgagat gcctgctgac ttgccttcat tagctgctga ttttgttgaa     1080

agtaaggatg tttgcaaaaa ctatgctgag gcaaaggatg tcttcctggg catgtttttg     1140

tatgaatatg caagaaggca tcctgattac tctgtcgtgc tgctgctgag acttgccaag     1200

acatatgaaa ccactctaga gaagtgctgt gccgctgcag atcctcatga atgctatgcc     1260

aaagtgttcg atgaatttaa acctcttgtg gaagagcctc agaatttaat caaacaaaac     1320

tgtgagcttt ttgagcagct tggagagtac aaattccaga atgcgctatt agttcgttac     1380

accaagaaag taccccaagt gtcaactcca actcttgtag aggtctcaag aaacctagga     1440

aaagtgggca gcaaatgttg taaacatcct gaagcaaaaa gaatgccctg tgcagaagac     1500

tatctatccg tggtcctgaa ccagttatgt gtgttgcatg agaaaacgcc agtaagtgac     1560

agagtcacaa aatgctgcac agagtccttg gtgaacaggc gaccatgctt ttcagctctg     1620

gaagtcgatg aaacatacgt tcccaaagag tttaatgctg aaacattcac cttccatgca     1680

gatatatgca cactttctga gaaggagaga caaatcaaga aacaaactgc acttgttgag     1740

cttgtgaaac acaagcccaa ggcaacaaaa gagcaactga aagctgttat ggatgatttc     1800

gcagcttttg tagagaagtg ctgcaaggct gacgataagg agacctgctt tgccgaggag     1860

ggtaaaaaac ttgttgctgc aagtcaagct gccttaggct tataacatct acatttaaaa     1920

gcatctcagc ctaccatgag aataagagaa agaaaatgaa gatcaaaagc ttattcatct     1980

gttttctttt tcgttggtgt aaagccaaca ccctgtctaa aaaacataaa tttctttaat     2040

cattttgcct cttttctctg tgcttcaatt aataaaaaat ggaaagaatc taatagagtg     2100

gtacagcact gttatttttc aaagatgtgt tgctatcctg aaaattctgt aggttctgtg     2160

gaagttccag tgttctctct tattccactt cggtagagga tttctagttt ctgtgggcta     2220

attaaataaa tcactaatac tcttctaagt taaaaaaa                             2258


<210>  60
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  61
<211>  3436
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-albumin DNA

<400>  61
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tcggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg aggatgcaca caagagtgag     1680

gttgctcatc ggtttaaaga tttgggagaa gaaaatttca aagccttggt gttgattgcc     1740

tttgctcagt atcttcagca gtgtccattt gaagatcatg taaaattagt gaatgaagta     1800

actgaatttg caaaaacatg tgtagctgat gagtcagctg aaaattgtga caaatcactt     1860

catacccttt ttggagacaa attatgcaca gttgcaactc ttcgtgaaac ctatggtgaa     1920

atggctgact gctgtgcaaa acaagaacct gagagaaatg aatgcttctt gcaacacaaa     1980

gatgacaacc caaacctccc ccgattggtc agaccagagg ttgatgtgat gtgcactgct     2040

tttcatgaca atgaagagac atttttgaaa aaatacttat atgaaattgc cagaagacat     2100

ccttactttt atgccccgga actccttttc tttgctaaaa ggtataaagc tgcttttaca     2160

gaatgttgcc aagctgctga taaagctgcc tgcctgttgc caaagctcga tgaacttcgg     2220

gatgaaggga aggcttcgtc tgccaaacag agactcaaat gtgccagtct ccaaaaattt     2280

ggagaaagag ctttcaaagc atgggcagtg gctcgcctga gccagagatt tcccaaagct     2340

gagtttgcag aagtttccaa gttagtgaca gatcttacca aagtccacac ggaatgctgc     2400

catggagatc tgcttgaatg tgctgatgac agggcggacc ttgccaagta tatctgtgaa     2460

aatcaggatt cgatctccag taaactgaag gaatgctgtg aaaaacctct gttggaaaaa     2520

tcccactgca ttgccgaagt ggaaaatgat gagatgcctg ctgacttgcc ttcattagct     2580

gctgattttg ttgaaagtaa ggatgtttgc aaaaactatg ctgaggcaaa ggatgtcttc     2640

ctgggcatgt ttttgtatga atatgcaaga aggcatcctg attactctgt cgtgctgctg     2700

ctgagacttg ccaagacata tgaaaccact ctagagaagt gctgtgccgc tgcagatcct     2760

catgaatgct atgccaaagt gttcgatgaa tttaaacctc ttgtggaaga gcctcagaat     2820

ttaatcaaac aaaactgtga gctttttgag cagcttggag agtacaaatt ccagaatgcg     2880

ctattagttc gttacaccaa gaaagtaccc caagtgtcaa ctccaactct tgtagaggtc     2940

tcaagaaacc taggaaaagt gggcagcaaa tgttgtaaac atcctgaagc aaaaagaatg     3000

ccctgtgcag aagactatct atccgtggtc ctgaaccagt tatgtgtgtt gcatgagaaa     3060

acgccagtaa gtgacagagt cacaaaatgc tgcacagagt ccttggtgaa caggcgacca     3120

tgcttttcag ctctggaagt cgatgaaaca tacgttccca aagagtttaa tgctgaaaca     3180

ttcaccttcc atgcagatat atgcacactt tctgagaagg agagacaaat caagaaacaa     3240

actgcacttg ttgagcttgt gaaacacaag cccaaggcaa caaaagagca actgaaagct     3300

gttatggatg atttcgcagc ttttgtagag aagtgctgca aggctgacga taaggagacc     3360

tgctttgccg aggagggtaa aaaacttgtt gctgcaagtc aagctgcctt aggcttataa     3420

tgaaagcttg atatcc                                                     3436


<210>  62
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-albumin polypeptide

<400>  62

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
545                 550                 555                 560 


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
                565                 570                 575     


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
            580                 585                 590         


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
        595                 600                 605             


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
    610                 615                 620                 


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
625                 630                 635                 640 


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
                645                 650                 655     


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
            660                 665                 670         


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
        675                 680                 685             


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
    690                 695                 700                 


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
705                 710                 715                 720 


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
                725                 730                 735     


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
            740                 745                 750         


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
        755                 760                 765             


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
    770                 775                 780                 


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
785                 790                 795                 800 


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
                805                 810                 815     


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
            820                 825                 830         


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
        835                 840                 845             


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
    850                 855                 860                 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
865                 870                 875                 880 


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
                885                 890                 895     


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
            900                 905                 910         


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
        915                 920                 925             


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
    930                 935                 940                 


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
945                 950                 955                 960 


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
                965                 970                 975     


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
            980                 985                 990         


Lys Arg Met Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
        995                 1000                 1005             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1010                 1015                 1020             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1025                 1030                 1035             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1040                 1045                 1050             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1055                 1060                 1065             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1070                 1075                 1080             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1085                 1090                 1095             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1100                 1105                 1110             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1115                 1120                 1125             


Gln Ala  Ala Leu Gly Leu 
    1130                 


<210>  63
<211>  1594
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1 DNA

<400>  63
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca atgataatct agaa                                 1594


<210>  64
<211>  522
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1 polypeptide

<400>  64

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
        515                 520         


<210>  65
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  (g4s)2 linker L1-1 DNA

<400>  65
gatcttggtg gaggtggatc tggtggtgga ggaagc                                 36


<210>  66
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  (g4s)2 linker L1-1

<400>  66

Asp Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  67
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  (g4s)2 linker L1-2 DNA

<400>  67
gatcctggtg gaggtggatc tggtggtgga ggaagc                                 36


<210>  68
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  (g4s)2 linker L1-2

<400>  68

Asp Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  69
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  69
accggtctcg aggatgcaca caagagtgag                                        30


<210>  70
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  70
ggatatcaag ctttcattat aagcctaagg cagcttgact t                           41


<210>  71
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  71
agatcttggt ggaggtggat ctggtggtgg aggaagcgat gaaccccccc agag             54


<210>  72
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  72
ggattccggt ggaggtggat ctggtggtgg aggaagcgat gaaccccccc agagcccc         58


<210>  73
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  73
agatcttggg tgttgagctt cttagtgtac tcctc                                  35


<210>  74
<211>  2818
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-RNase1 DNA

<400>  74
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatcc cttccctggg caaggaatcc cgggccaaga aattccagcg gcagcatatg     2460

gactcagaca gttcccccag cagcagctcc acctactgta accaaatgat gaggcgccgg     2520

aatatgacac aggggcggtg caaaccagtg aacacctttg tgcacgagcc cctggtagat     2580

gtccagaatg tctgtttcca ggaaaaggtc acctgcaaga acgggcaggg caactgctac     2640

aagagcaact ccagcatgca catcacagac tgccgcctga caaacggctc caggtacccc     2700

aactgtgcat accggaccag cccgaaggag agacacatca ttgtggcctg tgaagggagc     2760

ccatatgtgc cagtccactt tgatgcttct gtggaggact ctacctaata atctagaa       2818


<210>  75
<211>  930
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-RNase1 polypeptide

<400>  75

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Pro Ser 
785                 790                 795                 800 


Leu Gly Lys Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp 
                805                 810                 815     


Ser Asp Ser Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met 
            820                 825                 830         


Arg Arg Arg Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe 
        835                 840                 845             


Val His Glu Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys 
    850                 855                 860                 


Val Thr Cys Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser 
865                 870                 875                 880 


Met His Ile Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn 
                885                 890                 895     


Cys Ala Tyr Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys 
            900                 905                 910         


Glu Gly Ser Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp 
        915                 920                 925             


Ser Thr 
    930 


<210>  76
<211>  3442
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PON1 DNA

<400>  76
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatcc tcttcaggaa ccaccagtct tcttaccaaa cacgacttaa tgctctccga     2460

gaggtacaac ccgtagaact tcctaactgt aatttagtta aaggaatcga aactggctct     2520

gaagacttgg agatactgcc taatggactg gctttcatta gctctggatt aaagtatcct     2580

ggaataaaga gcttcaaccc caacagtcct ggaaaaatac ttctgatgga cctgaatgaa     2640

gaagatccaa cagtgttgga attggggatc actggaagta aatttgatgt atcttcattt     2700

aaccctcatg ggattagcac attcacagat gaagataatg ccatgtacct cctggtggtg     2760

aaccatccag atgccaagtc cacagtggag ttgtttaaat ttcaagaaga agaaaaatcg     2820

cttttgcatc taaaaaccat cagacataaa cttctgccta atttgaatga tattgttgct     2880

gtgggacctg agcactttta tggcacaaat gatcactatt ttcttgaccc ctacttacaa     2940

tcctgggaga tgtatttggg tttagcgtgg tcgtatgttg tctactatag tccaagtgaa     3000

gttcgagtgg tggcagaagg atttgatttt gctaatggaa tcaacatttc acccgatggc     3060

aagtatgtct atatagctga gttgctggct cataagattc atgtgtatga aaagcatgct     3120

aattggactt taactccatt gaagtccctt gactttaata ccctcgtgga taacatatct     3180

gtggatcctg agacaggaga cctttgggtt ggatgccatc ccaatggcat gaaaatcttc     3240

ttctatgact cagagaatcc tcctgcatca gaggtgcttc gaatccagaa cattctaaca     3300

gaagaaccta aagtgacaca ggtttatgca gaaaatggca cagtgttgca aggcagtaca     3360

gttgcctctg tgtacaaagg gaaactgctg attggcacag tgtttcacaa agctctttac     3420

tgtgagctct aataatctag aa                                              3442


<210>  77
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PON1 polypeptide

<400>  77

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
785                 790                 795                 800 


Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu 
                805                 810                 815     


Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu 
            820                 825                 830         


Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
        835                 840                 845             


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser 
    850                 855                 860                 


Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val 
865                 870                 875                 880 


Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn 
                885                 890                 895     


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu 
            900                 905                 910         


Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys 
        915                 920                 925             


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
    930                 935                 940                 


Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His 
945                 950                 955                 960 


Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln Ser 
                965                 970                 975     


Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser 
            980                 985                 990         


Pro Ser Glu Val Arg Val Val Ala  Glu Gly Phe Asp Phe  Ala Asn Gly 
        995                 1000                 1005             


Ile Asn  Ile Ser Pro Asp Gly  Lys Tyr Val Tyr Ile  Ala Glu Leu 
    1010                 1015                 1020             


Leu Ala  His Lys Ile His Val  Tyr Glu Lys His Ala  Asn Trp Thr 
    1025                 1030                 1035             


Leu Thr  Pro Leu Lys Ser Leu  Asp Phe Asn Thr Leu  Val Asp Asn 
    1040                 1045                 1050             


Ile Ser  Val Asp Pro Glu Thr  Gly Asp Leu Trp Val  Gly Cys His 
    1055                 1060                 1065             


Pro Asn  Gly Met Lys Ile Phe  Phe Tyr Asp Ser Glu  Asn Pro Pro 
    1070                 1075                 1080             


Ala Ser  Glu Val Leu Arg Ile  Gln Asn Ile Leu Thr  Glu Glu Pro 
    1085                 1090                 1095             


Lys Val  Thr Gln Val Tyr Ala  Glu Asn Gly Thr Val  Leu Gln Gly 
    1100                 1105                 1110             


Ser Thr  Val Ala Ser Val Tyr  Lys Gly Lys Leu Leu  Ile Gly Thr 
    1115                 1120                 1125             


Val Phe  His Lys Ala Leu Tyr  Cys Glu Leu 
    1130                 1135             


<210>  78
<211>  3442
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PON1 Q192K DNA

<400>  78
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatcc tcttcaggaa ccaccagtct tcttaccaaa cacgacttaa tgctctccga     2460

gaggtacaac ccgtagaact tcctaactgt aatttagtta aaggaatcga aactggctct     2520

gaagacttgg agatactgcc taatggactg gctttcatta gctctggatt aaagtatcct     2580

ggaataaaga gcttcaaccc caacagtcct ggaaaaatac ttctgatgga cctgaatgaa     2640

gaagatccaa cagtgttgga attggggatc actggaagta aatttgatgt atcttcattt     2700

aaccctcatg ggattagcac attcacagat gaagataatg ccatgtacct cctggtggtg     2760

aaccatccag atgccaagtc cacagtggag ttgtttaaat ttcaagaaga agaaaaatcg     2820

cttttgcatc taaaaaccat cagacataaa cttctgccta atttgaatga tattgttgct     2880

gtgggacctg agcactttta tggcacaaat gatcactatt ttcttgaccc ctacttaaaa     2940

tcctgggaga tgtatttggg tttagcgtgg tcgtatgttg tctactatag tccaagtgaa     3000

gttcgagtgg tggcagaagg atttgatttt gctaatggaa tcaacatttc acccgatggc     3060

aagtatgtct atatagctga gttgctggct cataagattc atgtgtatga aaagcatgct     3120

aattggactt taactccatt gaagtccctt gactttaata ccctcgtgga taacatatct     3180

gtggatcctg agacaggaga cctttgggtt ggatgccatc ccaatggcat gaaaatcttc     3240

ttctatgact cagagaatcc tcctgcatca gaggtgcttc gaatccagaa cattctaaca     3300

gaagaaccta aagtgacaca ggtttatgca gaaaatggca cagtgttgca aggcagtaca     3360

gttgcctctg tgtacaaagg gaaactgctg attggcacag tgtttcacaa agctctttac     3420

tgtgagctct aataatctag aa                                              3442


<210>  79
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PON1 Q192K polypeptide

<400>  79

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
785                 790                 795                 800 


Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu 
                805                 810                 815     


Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu 
            820                 825                 830         


Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
        835                 840                 845             


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser 
    850                 855                 860                 


Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val 
865                 870                 875                 880 


Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn 
                885                 890                 895     


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu 
            900                 905                 910         


Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys 
        915                 920                 925             


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
    930                 935                 940                 


Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His 
945                 950                 955                 960 


Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Lys Ser 
                965                 970                 975     


Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser 
            980                 985                 990         


Pro Ser Glu Val Arg Val Val Ala  Glu Gly Phe Asp Phe  Ala Asn Gly 
        995                 1000                 1005             


Ile Asn  Ile Ser Pro Asp Gly  Lys Tyr Val Tyr Ile  Ala Glu Leu 
    1010                 1015                 1020             


Leu Ala  His Lys Ile His Val  Tyr Glu Lys His Ala  Asn Trp Thr 
    1025                 1030                 1035             


Leu Thr  Pro Leu Lys Ser Leu  Asp Phe Asn Thr Leu  Val Asp Asn 
    1040                 1045                 1050             


Ile Ser  Val Asp Pro Glu Thr  Gly Asp Leu Trp Val  Gly Cys His 
    1055                 1060                 1065             


Pro Asn  Gly Met Lys Ile Phe  Phe Tyr Asp Ser Glu  Asn Pro Pro 
    1070                 1075                 1080             


Ala Ser  Glu Val Leu Arg Ile  Gln Asn Ile Leu Thr  Glu Glu Pro 
    1085                 1090                 1095             


Lys Val  Thr Gln Val Tyr Ala  Glu Asn Gly Thr Val  Leu Gln Gly 
    1100                 1105                 1110             


Ser Thr  Val Ala Ser Val Tyr  Lys Gly Lys Leu Leu  Ile Gly Thr 
    1115                 1120                 1125             


Val Phe  His Lys Ala Leu Tyr  Cys Glu Leu 
    1130                 1135             


<210>  80
<211>  3442
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PON1 Q192R DNA

<400>  80
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatcc tcttcaggaa ccaccagtct tcttaccaaa cacgacttaa tgctctccga     2460

gaggtacaac ccgtagaact tcctaactgt aatttagtta aaggaatcga aactggctct     2520

gaagacttgg agatactgcc taatggactg gctttcatta gctctggatt aaagtatcct     2580

ggaataaaga gcttcaaccc caacagtcct ggaaaaatac ttctgatgga cctgaatgaa     2640

gaagatccaa cagtgttgga attggggatc actggaagta aatttgatgt atcttcattt     2700

aaccctcatg ggattagcac attcacagat gaagataatg ccatgtacct cctggtggtg     2760

aaccatccag atgccaagtc cacagtggag ttgtttaaat ttcaagaaga agaaaaatcg     2820

cttttgcatc taaaaaccat cagacataaa cttctgccta atttgaatga tattgttgct     2880

gtgggacctg agcactttta tggcacaaat gatcactatt ttcttgaccc ctacttaaga     2940

tcctgggaga tgtatttggg tttagcgtgg tcgtatgttg tctactatag tccaagtgaa     3000

gttcgagtgg tggcagaagg atttgatttt gctaatggaa tcaacatttc acccgatggc     3060

aagtatgtct atatagctga gttgctggct cataagattc atgtgtatga aaagcatgct     3120

aattggactt taactccatt gaagtccctt gactttaata ccctcgtgga taacatatct     3180

gtggatcctg agacaggaga cctttgggtt ggatgccatc ccaatggcat gaaaatcttc     3240

ttctatgact cagagaatcc tcctgcatca gaggtgcttc gaatccagaa cattctaaca     3300

gaagaaccta aagtgacaca ggtttatgca gaaaatggca cagtgttgca aggcagtaca     3360

gttgcctctg tgtacaaagg gaaactgctg attggcacag tgtttcacaa agctctttac     3420

tgtgagctct aataatctag aa                                              3442


<210>  81
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PON1 Q192R polypeptide

<400>  81

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Leu Phe 
785                 790                 795                 800 


Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg Glu 
                805                 810                 815     


Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile Glu 
            820                 825                 830         


Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe Ile 
        835                 840                 845             


Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn Ser 
    850                 855                 860                 


Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr Val 
865                 870                 875                 880 


Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe Asn 
                885                 890                 895     


Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr Leu 
            900                 905                 910         


Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe Lys 
        915                 920                 925             


Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg His 
    930                 935                 940                 


Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu His 
945                 950                 955                 960 


Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Arg Ser 
                965                 970                 975     


Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr Ser 
            980                 985                 990         


Pro Ser Glu Val Arg Val Val Ala  Glu Gly Phe Asp Phe  Ala Asn Gly 
        995                 1000                 1005             


Ile Asn  Ile Ser Pro Asp Gly  Lys Tyr Val Tyr Ile  Ala Glu Leu 
    1010                 1015                 1020             


Leu Ala  His Lys Ile His Val  Tyr Glu Lys His Ala  Asn Trp Thr 
    1025                 1030                 1035             


Leu Thr  Pro Leu Lys Ser Leu  Asp Phe Asn Thr Leu  Val Asp Asn 
    1040                 1045                 1050             


Ile Ser  Val Asp Pro Glu Thr  Gly Asp Leu Trp Val  Gly Cys His 
    1055                 1060                 1065             


Pro Asn  Gly Met Lys Ile Phe  Phe Tyr Asp Ser Glu  Asn Pro Pro 
    1070                 1075                 1080             


Ala Ser  Glu Val Leu Arg Ile  Gln Asn Ile Leu Thr  Glu Glu Pro 
    1085                 1090                 1095             


Lys Val  Thr Gln Val Tyr Ala  Glu Asn Gly Thr Val  Leu Gln Gly 
    1100                 1105                 1110             


Ser Thr  Val Ala Ser Val Tyr  Lys Gly Lys Leu Leu  Ile Gly Thr 
    1115                 1120                 1125             


Val Phe  His Lys Ala Leu Tyr  Cys Glu Leu 
    1130                 1135             


<210>  82
<211>  3672
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PAFAH DNA

<400>  82
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatct ttgactggca atacataaat cctgttgccc atatgaaatc atcagcatgg     2460

gtcaacaaaa tacaagtact gatggctgct gcaagctttg gccaaactaa aatcccccgg     2520

ggaaatgggc cttattccgt tggttgtaca gacttaatgt ttgatcacac taataagggc     2580

accttcttgc gtttatatta tccatcccaa gataatgatc gccttgacac cctttggatc     2640

ccaaataaag aatatttttg gggtcttagc aaatttcttg gaacacactg gcttatgggc     2700

aacattttga ggttactctt tggttcaatg acaactcctg caaactggaa ttcccctctg     2760

aggcctggtg aaaaatatcc acttgttgtt ttttctcatg gtcttggggc attcaggaca     2820

ctttattctg ctattggcat tgacctggca tctcatgggt ttatagttgc tgctgtagaa     2880

cacagagata gatctgcatc tgcaacttac tatttcaagg accaatctgc tgcagaaata     2940

ggggacaagt cttggctcta ccttagaacc ctgaaacaag aggaggagac acatatacga     3000

aatgagcagg tacggcaaag agcaaaagaa tgttcccaag ctctcagtct gattcttgac     3060

attgatcatg gaaagccagt gaagaatgca ttagatttaa agtttgatat ggaacaactg     3120

aaggactcta ttgataggga aaaaatagca gtaattggac attcttttgg tggagcaacg     3180

gttattcaga ctcttagtga agatcagaga ttcagatgtg gtattgccct ggatgcatgg     3240

atgtttccac tgggtgatga agtatattcc agaattcctc agcccctctt ttttatcaac     3300

tctgaatatt tccaatatcc tgctaatatc ataaaaatga aaaaatgcta ctcacctgat     3360

aaagaaagaa agatgattac aatcaggggt tcagtccacc agaattttgc tgacttcact     3420

tttgcaactg gcaaaataat tggacacatg ctcaaattaa agggagacat agattcaaat     3480

gtagctattg atcttagcaa caaagcttca ttagcattct tacaaaagca tttaggactt     3540

cataaagatt ttgatcagtg ggactgcttg attgaaggag atgatgagaa tcttattcca     3600

gggaccaaca ttaacacaac caatcaacac atcatgttac agaactcttc aggaatagag     3660

aaatacaatt ag                                                         3672


<210>  83
<211>  1218
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-PAFAH polypeptide

<400>  83

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Phe Asp 
785                 790                 795                 800 


Trp Gln Tyr Ile Asn Pro Val Ala His Met Lys Ser Ser Ala Trp Val 
                805                 810                 815     


Asn Lys Ile Gln Val Leu Met Ala Ala Ala Ser Phe Gly Gln Thr Lys 
            820                 825                 830         


Ile Pro Arg Gly Asn Gly Pro Tyr Ser Val Gly Cys Thr Asp Leu Met 
        835                 840                 845             


Phe Asp His Thr Asn Lys Gly Thr Phe Leu Arg Leu Tyr Tyr Pro Ser 
    850                 855                 860                 


Gln Asp Asn Asp Arg Leu Asp Thr Leu Trp Ile Pro Asn Lys Glu Tyr 
865                 870                 875                 880 


Phe Trp Gly Leu Ser Lys Phe Leu Gly Thr His Trp Leu Met Gly Asn 
                885                 890                 895     


Ile Leu Arg Leu Leu Phe Gly Ser Met Thr Thr Pro Ala Asn Trp Asn 
            900                 905                 910         


Ser Pro Leu Arg Pro Gly Glu Lys Tyr Pro Leu Val Val Phe Ser His 
        915                 920                 925             


Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Ile Gly Ile Asp Leu 
    930                 935                 940                 


Ala Ser His Gly Phe Ile Val Ala Ala Val Glu His Arg Asp Arg Ser 
945                 950                 955                 960 


Ala Ser Ala Thr Tyr Tyr Phe Lys Asp Gln Ser Ala Ala Glu Ile Gly 
                965                 970                 975     


Asp Lys Ser Trp Leu Tyr Leu Arg Thr Leu Lys Gln Glu Glu Glu Thr 
            980                 985                 990         


His Ile Arg Asn Glu Gln Val Arg  Gln Arg Ala Lys Glu  Cys Ser Gln 
        995                 1000                 1005             


Ala Leu  Ser Leu Ile Leu Asp  Ile Asp His Gly Lys  Pro Val Lys 
    1010                 1015                 1020             


Asn Ala  Leu Asp Leu Lys Phe  Asp Met Glu Gln Leu  Lys Asp Ser 
    1025                 1030                 1035             


Ile Asp  Arg Glu Lys Ile Ala  Val Ile Gly His Ser  Phe Gly Gly 
    1040                 1045                 1050             


Ala Thr  Val Ile Gln Thr Leu  Ser Glu Asp Gln Arg  Phe Arg Cys 
    1055                 1060                 1065             


Gly Ile  Ala Leu Asp Ala Trp  Met Phe Pro Leu Gly  Asp Glu Val 
    1070                 1075                 1080             


Tyr Ser  Arg Ile Pro Gln Pro  Leu Phe Phe Ile Asn  Ser Glu Tyr 
    1085                 1090                 1095             


Phe Gln  Tyr Pro Ala Asn Ile  Ile Lys Met Lys Lys  Cys Tyr Ser 
    1100                 1105                 1110             


Pro Asp  Lys Glu Arg Lys Met  Ile Thr Ile Arg Gly  Ser Val His 
    1115                 1120                 1125             


Gln Asn  Phe Ala Asp Phe Thr  Phe Ala Thr Gly Lys  Ile Ile Gly 
    1130                 1135                 1140             


His Met  Leu Lys Leu Lys Gly  Asp Ile Asp Ser Asn  Val Ala Ile 
    1145                 1150                 1155             


Asp Leu  Ser Asn Lys Ala Ser  Leu Ala Phe Leu Gln  Lys His Leu 
    1160                 1165                 1170             


Gly Leu  His Lys Asp Phe Asp  Gln Trp Asp Cys Leu  Ile Glu Gly 
    1175                 1180                 1185             


Asp Asp  Glu Asn Leu Ile Pro  Gly Thr Asn Ile Asn  Thr Thr Asn 
    1190                 1195                 1200             


Gln His  Ile Met Leu Gln Asn  Ser Ser Gly Ile Glu  Lys Tyr Asn 
    1205                 1210                 1215             


<210>  84
<211>  3849
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-CETP DNA

<400>  84
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatct gctccaaagg cacctcgcac gaggcaggca tcgtgtgccg catcaccaag     2460

cctgccctcc tggtgttgaa ccacgagact gccaaggtga tccagaccgc cttccagcga     2520

gccagctacc cagatatcac gggcgagaag gccatgatgc tccttggcca agtcaagtat     2580

gggttgcaca acatccagat cagccacttg tccatcgcca gcagccaggt ggagctggtg     2640

gaagccaagt ccattgatgt ctccattcag aacgtgtctg tggtcttcaa ggggaccctg     2700

aagtatggct acaccactgc ctggtggctg ggtattgatc agtccattga cttcgagatc     2760

gactctgcca ttgacctcca gatcaacaca cagctgacct gtgactctgg tagagtgcgg     2820

accgatgccc ctgactgcta cctgtctttc cataagctgc tcctgcatct ccaaggggag     2880

cgagagcctg ggtggatcaa gcagctgttc acaaatttca tctccttcac cctgaagctg     2940

gtcctgaagg gacagatctg caaagagatc aacgtcatct ctaacatcat ggccgatttt     3000

gtccagacaa gggctgccag catcctttca gatggagaca ttggggtgga catttccctg     3060

acaggtgatc ccgtcatcac agcctcctac ctggagtccc atcacaaggg tcatttcatc     3120

tacaagaatg tctcagagga cctccccctc cccaccttct cgcccacact gctgggggac     3180

tcccgcatgc tgtacttctg gttctctgag cgagtcttcc actcgctggc caaggtagct     3240

ttccaggatg gccgcctcat gctcagcctg atgggagacg agttcaaggc agtgctggag     3300

acctggggct tcaacaccaa ccaggaaatc ttccaagagg ttgtcggcgg cttccccagc     3360

caggcccaag tcaccgtcca ctgcctcaag atgcccaaga tctcctgcca aaacaaggga     3420

gtcgtggtca attcttcagt gatggtgaaa ttcctctttc cacgcccaga ccagcaacat     3480

tctgtagctt acacatttga agaggatatc gtgactaccg tccaggcctc ctattctaag     3540

aaaaagctct tcttaagcct cttggatttc cagattacac caaagactgt ttccaacttg     3600

actgagagca gctccgagtc cgtccagagc ttcctgcagt caatgatcac cgctgtgggc     3660

atccctgagg tcatgtctcg gctcgaggta gtgtttacag ccctcatgaa cagcaaaggc     3720

gtgagcctct tcgacatcat caaccctgag attatcactc gagatggctt cctgctgctg     3780

cagatggact ttggcttccc tgagcacctg ctggtggatt tcctccagag cttgagctaa     3840

taatctaga                                                             3849


<210>  85
<211>  1274
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-CETP polypeptide

<400>  85

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Cys Ser 
785                 790                 795                 800 


Lys Gly Thr Ser His Glu Ala Gly Ile Val Cys Arg Ile Thr Lys Pro 
                805                 810                 815     


Ala Leu Leu Val Leu Asn His Glu Thr Ala Lys Val Ile Gln Thr Ala 
            820                 825                 830         


Phe Gln Arg Ala Ser Tyr Pro Asp Ile Thr Gly Glu Lys Ala Met Met 
        835                 840                 845             


Leu Leu Gly Gln Val Lys Tyr Gly Leu His Asn Ile Gln Ile Ser His 
    850                 855                 860                 


Leu Ser Ile Ala Ser Ser Gln Val Glu Leu Val Glu Ala Lys Ser Ile 
865                 870                 875                 880 


Asp Val Ser Ile Gln Asn Val Ser Val Val Phe Lys Gly Thr Leu Lys 
                885                 890                 895     


Tyr Gly Tyr Thr Thr Ala Trp Trp Leu Gly Ile Asp Gln Ser Ile Asp 
            900                 905                 910         


Phe Glu Ile Asp Ser Ala Ile Asp Leu Gln Ile Asn Thr Gln Leu Thr 
        915                 920                 925             


Cys Asp Ser Gly Arg Val Arg Thr Asp Ala Pro Asp Cys Tyr Leu Ser 
    930                 935                 940                 


Phe His Lys Leu Leu Leu His Leu Gln Gly Glu Arg Glu Pro Gly Trp 
945                 950                 955                 960 


Ile Lys Gln Leu Phe Thr Asn Phe Ile Ser Phe Thr Leu Lys Leu Val 
                965                 970                 975     


Leu Lys Gly Gln Ile Cys Lys Glu Ile Asn Val Ile Ser Asn Ile Met 
            980                 985                 990         


Ala Asp Phe Val Gln Thr Arg Ala  Ala Ser Ile Leu Ser  Asp Gly Asp 
        995                 1000                 1005             


Ile Gly  Val Asp Ile Ser Leu  Thr Gly Asp Pro Val  Ile Thr Ala 
    1010                 1015                 1020             


Ser Tyr  Leu Glu Ser His His  Lys Gly His Phe Ile  Tyr Lys Asn 
    1025                 1030                 1035             


Val Ser  Glu Asp Leu Pro Leu  Pro Thr Phe Ser Pro  Thr Leu Leu 
    1040                 1045                 1050             


Gly Asp  Ser Arg Met Leu Tyr  Phe Trp Phe Ser Glu  Arg Val Phe 
    1055                 1060                 1065             


His Ser  Leu Ala Lys Val Ala  Phe Gln Asp Gly Arg  Leu Met Leu 
    1070                 1075                 1080             


Ser Leu  Met Gly Asp Glu Phe  Lys Ala Val Leu Glu  Thr Trp Gly 
    1085                 1090                 1095             


Phe Asn  Thr Asn Gln Glu Ile  Phe Gln Glu Val Val  Gly Gly Phe 
    1100                 1105                 1110             


Pro Ser  Gln Ala Gln Val Thr  Val His Cys Leu Lys  Met Pro Lys 
    1115                 1120                 1125             


Ile Ser  Cys Gln Asn Lys Gly  Val Val Val Asn Ser  Ser Val Met 
    1130                 1135                 1140             


Val Lys  Phe Leu Phe Pro Arg  Pro Asp Gln Gln His  Ser Val Ala 
    1145                 1150                 1155             


Tyr Thr  Phe Glu Glu Asp Ile  Val Thr Thr Val Gln  Ala Ser Tyr 
    1160                 1165                 1170             


Ser Lys  Lys Lys Leu Phe Leu  Ser Leu Leu Asp Phe  Gln Ile Thr 
    1175                 1180                 1185             


Pro Lys  Thr Val Ser Asn Leu  Thr Glu Ser Ser Ser  Glu Ser Val 
    1190                 1195                 1200             


Gln Ser  Phe Leu Gln Ser Met  Ile Thr Ala Val Gly  Ile Pro Glu 
    1205                 1210                 1215             


Val Met  Ser Arg Leu Glu Val  Val Phe Thr Ala Leu  Met Asn Ser 
    1220                 1225                 1230             


Lys Gly  Val Ser Leu Phe Asp  Ile Ile Asn Pro Glu  Ile Ile Thr 
    1235                 1240                 1245             


Arg Asp  Gly Phe Leu Leu Leu  Gln Met Asp Phe Gly  Phe Pro Glu 
    1250                 1255                 1260             


His Leu  Leu Val Asp Phe Leu  Gln Ser Leu Ser 
    1265                 1270                 


<210>  86
<211>  3868
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-albumin-L3-RNase1 DNA

<400>  86
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tcggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg aggatgcaca caagagtgag     1680

gttgctcatc ggtttaaaga tttgggagaa gaaaatttca aagccttggt gttgattgcc     1740

tttgctcagt atcttcagca gtgtccattt gaagatcatg taaaattagt gaatgaagta     1800

actgaatttg caaaaacatg tgtagctgat gagtcagctg aaaattgtga caaatcactt     1860

catacccttt ttggagacaa attatgcaca gttgcaactc ttcgtgaaac ctatggtgaa     1920

atggctgact gctgtgcaaa acaagaacct gagagaaatg aatgcttctt gcaacacaaa     1980

gatgacaacc caaacctccc ccgattggtc agaccagagg ttgatgtgat gtgcactgct     2040

tttcatgaca atgaagagac atttttgaaa aaatacttat atgaaattgc cagaagacat     2100

ccttactttt atgccccgga actccttttc tttgctaaaa ggtataaagc tgcttttaca     2160

gaatgttgcc aagctgctga taaagctgcc tgcctgttgc caaagctcga tgaacttcgg     2220

gatgaaggga aggcttcgtc tgccaaacag agactcaaat gtgccagtct ccaaaaattt     2280

ggagaaagag ctttcaaagc atgggcagtg gctcgcctga gccagagatt tcccaaagct     2340

gagtttgcag aagtttccaa gttagtgaca gatcttacca aagtccacac ggaatgctgc     2400

catggagatc tgcttgaatg tgctgatgac agggcggacc ttgccaagta tatctgtgaa     2460

aatcaggatt cgatctccag taaactgaag gaatgctgtg aaaaacctct gttggaaaaa     2520

tcccactgca ttgccgaagt ggaaaatgat gagatgcctg ctgacttgcc ttcattagct     2580

gctgattttg ttgaaagtaa ggatgtttgc aaaaactatg ctgaggcaaa ggatgtcttc     2640

ctgggcatgt ttttgtatga atatgcaaga aggcatcctg attactctgt cgtgctgctg     2700

ctgagacttg ccaagacata tgaaaccact ctagagaagt gctgtgccgc tgcagatcct     2760

catgaatgct atgccaaagt gttcgatgaa tttaaacctc ttgtggaaga gcctcagaat     2820

ttaatcaaac aaaactgtga gctttttgag cagcttggag agtacaaatt ccagaatgcg     2880

ctattagttc gttacaccaa gaaagtaccc caagtgtcaa ctccaactct tgtagaggtc     2940

tcaagaaacc taggaaaagt gggcagcaaa tgttgtaaac atcctgaagc aaaaagaatg     3000

ccctgtgcag aagactatct atccgtggtc ctgaaccagt tatgtgtgtt gcatgagaaa     3060

acgccagtaa gtgacagagt cacaaaatgc tgcacagagt ccttggtgaa caggcgacca     3120

tgcttttcag ctctggaagt cgatgaaaca tacgttccca aagagtttaa tgctgaaaca     3180

ttcaccttcc atgcagatat atgcacactt tctgagaagg agagacaaat caagaaacaa     3240

actgcacttg ttgagcttgt gaaacacaag cccaaggcaa caaaagagca actgaaagct     3300

gttatggatg atttcgcagc ttttgtagag aagtgctgca aggctgacga taaggagacc     3360

tgctttgccg aggagggtaa aaaacttgtt gctgcaagtc aagctgcctt aggcttagtc     3420

gacggagcta gcagccccgt gaacgtgagc agccccagcg tgcaggatat caaggaatcc     3480

cgggccaaga aattccagcg gcagcatatg gactcagaca gttcccccag cagcagctcc     3540

acctactgta accaaatgat gaggcgccgg aatatgacac aggggcggtg caaaccagtg     3600

aacacctttg tgcacgagcc cctggtagat gtccagaatg tctgtttcca ggaaaaggtc     3660

acctgcaaga acgggcaggg caactgctac aagagcaact ccagcatgca catcacagac     3720

tgccgcctga caaacggctc caggtacccc aactgtgcat accggaccag cccgaaggag     3780

agacacatca ttgtggcctg tgaagggagc ccatatgtgc cagtccactt tgatgcttct     3840

gtggaggact ctacctaata atctagaa                                        3868


<210>  87
<211>  1280
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-albumin-L3-RNase1 polypeptide

<400>  87

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
545                 550                 555                 560 


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
                565                 570                 575     


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
            580                 585                 590         


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
        595                 600                 605             


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
    610                 615                 620                 


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
625                 630                 635                 640 


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
                645                 650                 655     


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
            660                 665                 670         


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
        675                 680                 685             


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
    690                 695                 700                 


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
705                 710                 715                 720 


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
                725                 730                 735     


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
            740                 745                 750         


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
        755                 760                 765             


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
    770                 775                 780                 


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
785                 790                 795                 800 


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
                805                 810                 815     


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
            820                 825                 830         


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
        835                 840                 845             


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
    850                 855                 860                 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
865                 870                 875                 880 


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
                885                 890                 895     


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
            900                 905                 910         


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
        915                 920                 925             


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
    930                 935                 940                 


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
945                 950                 955                 960 


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
                965                 970                 975     


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
            980                 985                 990         


Lys Arg Met Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
        995                 1000                 1005             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1010                 1015                 1020             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1025                 1030                 1035             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1040                 1045                 1050             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1055                 1060                 1065             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1070                 1075                 1080             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1085                 1090                 1095             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1100                 1105                 1110             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1115                 1120                 1125             


Gln Ala  Ala Leu Gly Leu Val  Asp Gly Ala Ser Ser  Pro Val Asn 
    1130                 1135                 1140             


Val Ser  Ser Pro Ser Val Gln  Asp Ile Lys Glu Ser  Arg Ala Lys 
    1145                 1150                 1155             


Lys Phe  Gln Arg Gln His Met  Asp Ser Asp Ser Ser  Pro Ser Ser 
    1160                 1165                 1170             


Ser Ser  Thr Tyr Cys Asn Gln  Met Met Arg Arg Arg  Asn Met Thr 
    1175                 1180                 1185             


Gln Gly  Arg Cys Lys Pro Val  Asn Thr Phe Val His  Glu Pro Leu 
    1190                 1195                 1200             


Val Asp  Val Gln Asn Val Cys  Phe Gln Glu Lys Val  Thr Cys Lys 
    1205                 1210                 1215             


Asn Gly  Gln Gly Asn Cys Tyr  Lys Ser Asn Ser Ser  Met His Ile 
    1220                 1225                 1230             


Thr Asp  Cys Arg Leu Thr Asn  Gly Ser Arg Tyr Pro  Asn Cys Ala 
    1235                 1240                 1245             


Tyr Arg  Thr Ser Pro Lys Glu  Arg His Ile Ile Val  Ala Cys Glu 
    1250                 1255                 1260             


Gly Ser  Pro Tyr Val Pro Val  His Phe Asp Ala Ser  Val Glu Asp 
    1265                 1270                 1275             


Ser Thr  
    1280 


<210>  88
<211>  4504
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-albumin-L3-PON1 DNA

<400>  88
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tcggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg aggatgcaca caagagtgag     1680

gttgctcatc ggtttaaaga tttgggagaa gaaaatttca aagccttggt gttgattgcc     1740

tttgctcagt atcttcagca gtgtccattt gaagatcatg taaaattagt gaatgaagta     1800

actgaatttg caaaaacatg tgtagctgat gagtcagctg aaaattgtga caaatcactt     1860

catacccttt ttggagacaa attatgcaca gttgcaactc ttcgtgaaac ctatggtgaa     1920

atggctgact gctgtgcaaa acaagaacct gagagaaatg aatgcttctt gcaacacaaa     1980

gatgacaacc caaacctccc ccgattggtc agaccagagg ttgatgtgat gtgcactgct     2040

tttcatgaca atgaagagac atttttgaaa aaatacttat atgaaattgc cagaagacat     2100

ccttactttt atgccccgga actccttttc tttgctaaaa ggtataaagc tgcttttaca     2160

gaatgttgcc aagctgctga taaagctgcc tgcctgttgc caaagctcga tgaacttcgg     2220

gatgaaggga aggcttcgtc tgccaaacag agactcaaat gtgccagtct ccaaaaattt     2280

ggagaaagag ctttcaaagc atgggcagtg gctcgcctga gccagagatt tcccaaagct     2340

gagtttgcag aagtttccaa gttagtgaca gatcttacca aagtccacac ggaatgctgc     2400

catggagatc tgcttgaatg tgctgatgac agggcggacc ttgccaagta tatctgtgaa     2460

aatcaggatt cgatctccag taaactgaag gaatgctgtg aaaaacctct gttggaaaaa     2520

tcccactgca ttgccgaagt ggaaaatgat gagatgcctg ctgacttgcc ttcattagct     2580

gctgattttg ttgaaagtaa ggatgtttgc aaaaactatg ctgaggcaaa ggatgtcttc     2640

ctgggcatgt ttttgtatga atatgcaaga aggcatcctg attactctgt cgtgctgctg     2700

ctgagacttg ccaagacata tgaaaccact ctagagaagt gctgtgccgc tgcagatcct     2760

catgaatgct atgccaaagt gttcgatgaa tttaaacctc ttgtggaaga gcctcagaat     2820

ttaatcaaac aaaactgtga gctttttgag cagcttggag agtacaaatt ccagaatgcg     2880

ctattagttc gttacaccaa gaaagtaccc caagtgtcaa ctccaactct tgtagaggtc     2940

tcaagaaacc taggaaaagt gggcagcaaa tgttgtaaac atcctgaagc aaaaagaatg     3000

ccctgtgcag aagactatct atccgtggtc ctgaaccagt tatgtgtgtt gcatgagaaa     3060

acgccagtaa gtgacagagt cacaaaatgc tgcacagagt ccttggtgaa caggcgacca     3120

tgcttttcag ctctggaagt cgatgaaaca tacgttccca aagagtttaa tgctgaaaca     3180

ttcaccttcc atgcagatat atgcacactt tctgagaagg agagacaaat caagaaacaa     3240

actgcacttg ttgagcttgt gaaacacaag cccaaggcaa caaaagagca actgaaagct     3300

gttatggatg atttcgcagc ttttgtagag aagtgctgca aggctgacga taaggagacc     3360

tgctttgccg aggagggtaa aaaacttgtt gctgcaagtc aagctgcctt aggcttagtc     3420

gacggagcta gcagccccgt gaacgtgagc agccccagcg tgcaggatat cctcttcagg     3480

aaccaccagt cttcttacca aacacgactt aatgctctcc gagaggtaca acccgtagaa     3540

cttcctaact gtaatttagt taaaggaatc gaaactggct ctgaagactt ggagatactg     3600

cctaatggac tggctttcat tagctctgga ttaaagtatc ctggaataaa gagcttcaac     3660

cccaacagtc ctggaaaaat acttctgatg gacctgaatg aagaagatcc aacagtgttg     3720

gaattgggga tcactggaag taaatttgat gtatcttcat ttaaccctca tgggattagc     3780

acattcacag atgaagataa tgccatgtac ctcctggtgg tgaaccatcc agatgccaag     3840

tccacagtgg agttgtttaa atttcaagaa gaagaaaaat cgcttttgca tctaaaaacc     3900

atcagacata aacttctgcc taatttgaat gatattgttg ctgtgggacc tgagcacttt     3960

tatggcacaa atgatcacta ttttcttgac ccctacttac aatcctggga gatgtatttg     4020

ggtttagcgt ggtcgtatgt tgtctactat agtccaagtg aagttcgagt ggtggcagaa     4080

ggatttgatt ttgctaatgg aatcaacatt tcacccgatg gcaagtatgt ctatatagct     4140

gagttgctgg ctcataagat tcatgtgtat gaaaagcatg ctaattggac tttaactcca     4200

ttgaagtccc ttgactttaa taccctcgtg gataacatat ctgtggatcc tgagacagga     4260

gacctttggg ttggatgcca tcccaatggc atgaaaatct tcttctatga ctcagagaat     4320

cctcctgcat cagaggtgct tcgaatccag aacattctaa cagaagaacc taaagtgaca     4380

caggtttatg cagaaaatgg cacagtgttg caaggcagta cagttgcctc tgtgtacaaa     4440

gggaaactgc tgattggcac agtgtttcac aaagctcttt actgtgagct ctaataatct     4500

agaa                                                                  4504


<210>  89
<211>  1492
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-albumin-L3-PON1 polypeptide

<400>  89

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
545                 550                 555                 560 


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
                565                 570                 575     


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
            580                 585                 590         


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
        595                 600                 605             


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
    610                 615                 620                 


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
625                 630                 635                 640 


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
                645                 650                 655     


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
            660                 665                 670         


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
        675                 680                 685             


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
    690                 695                 700                 


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
705                 710                 715                 720 


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
                725                 730                 735     


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
            740                 745                 750         


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
        755                 760                 765             


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
    770                 775                 780                 


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
785                 790                 795                 800 


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
                805                 810                 815     


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
            820                 825                 830         


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
        835                 840                 845             


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
    850                 855                 860                 


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
865                 870                 875                 880 


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
                885                 890                 895     


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
            900                 905                 910         


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
        915                 920                 925             


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
    930                 935                 940                 


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
945                 950                 955                 960 


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
                965                 970                 975     


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
            980                 985                 990         


Lys Arg Met Pro Cys Ala Glu Asp  Tyr Leu Ser Val Val  Leu Asn Gln 
        995                 1000                 1005             


Leu Cys  Val Leu His Glu Lys  Thr Pro Val Ser Asp  Arg Val Thr 
    1010                 1015                 1020             


Lys Cys  Cys Thr Glu Ser Leu  Val Asn Arg Arg Pro  Cys Phe Ser 
    1025                 1030                 1035             


Ala Leu  Glu Val Asp Glu Thr  Tyr Val Pro Lys Glu  Phe Asn Ala 
    1040                 1045                 1050             


Glu Thr  Phe Thr Phe His Ala  Asp Ile Cys Thr Leu  Ser Glu Lys 
    1055                 1060                 1065             


Glu Arg  Gln Ile Lys Lys Gln  Thr Ala Leu Val Glu  Leu Val Lys 
    1070                 1075                 1080             


His Lys  Pro Lys Ala Thr Lys  Glu Gln Leu Lys Ala  Val Met Asp 
    1085                 1090                 1095             


Asp Phe  Ala Ala Phe Val Glu  Lys Cys Cys Lys Ala  Asp Asp Lys 
    1100                 1105                 1110             


Glu Thr  Cys Phe Ala Glu Glu  Gly Lys Lys Leu Val  Ala Ala Ser 
    1115                 1120                 1125             


Gln Ala  Ala Leu Gly Leu Val  Asp Gly Ala Ser Ser  Pro Val Asn 
    1130                 1135                 1140             


Val Ser  Ser Pro Ser Val Gln  Asp Ile Leu Phe Arg  Asn His Gln 
    1145                 1150                 1155             


Ser Ser  Tyr Gln Thr Arg Leu  Asn Ala Leu Arg Glu  Val Gln Pro 
    1160                 1165                 1170             


Val Glu  Leu Pro Asn Cys Asn  Leu Val Lys Gly Ile  Glu Thr Gly 
    1175                 1180                 1185             


Ser Glu  Asp Leu Glu Ile Leu  Pro Asn Gly Leu Ala  Phe Ile Ser 
    1190                 1195                 1200             


Ser Gly  Leu Lys Tyr Pro Gly  Ile Lys Ser Phe Asn  Pro Asn Ser 
    1205                 1210                 1215             


Pro Gly  Lys Ile Leu Leu Met  Asp Leu Asn Glu Glu  Asp Pro Thr 
    1220                 1225                 1230             


Val Leu  Glu Leu Gly Ile Thr  Gly Ser Lys Phe Asp  Val Ser Ser 
    1235                 1240                 1245             


Phe Asn  Pro His Gly Ile Ser  Thr Phe Thr Asp Glu  Asp Asn Ala 
    1250                 1255                 1260             


Met Tyr  Leu Leu Val Val Asn  His Pro Asp Ala Lys  Ser Thr Val 
    1265                 1270                 1275             


Glu Leu  Phe Lys Phe Gln Glu  Glu Glu Lys Ser Leu  Leu His Leu 
    1280                 1285                 1290             


Lys Thr  Ile Arg His Lys Leu  Leu Pro Asn Leu Asn  Asp Ile Val 
    1295                 1300                 1305             


Ala Val  Gly Pro Glu His Phe  Tyr Gly Thr Asn Asp  His Tyr Phe 
    1310                 1315                 1320             


Leu Asp  Pro Tyr Leu Gln Ser  Trp Glu Met Tyr Leu  Gly Leu Ala 
    1325                 1330                 1335             


Trp Ser  Tyr Val Val Tyr Tyr  Ser Pro Ser Glu Val  Arg Val Val 
    1340                 1345                 1350             


Ala Glu  Gly Phe Asp Phe Ala  Asn Gly Ile Asn Ile  Ser Pro Asp 
    1355                 1360                 1365             


Gly Lys  Tyr Val Tyr Ile Ala  Glu Leu Leu Ala His  Lys Ile His 
    1370                 1375                 1380             


Val Tyr  Glu Lys His Ala Asn  Trp Thr Leu Thr Pro  Leu Lys Ser 
    1385                 1390                 1395             


Leu Asp  Phe Asn Thr Leu Val  Asp Asn Ile Ser Val  Asp Pro Glu 
    1400                 1405                 1410             


Thr Gly  Asp Leu Trp Val Gly  Cys His Pro Asn Gly  Met Lys Ile 
    1415                 1420                 1425             


Phe Phe  Tyr Asp Ser Glu Asn  Pro Pro Ala Ser Glu  Val Leu Arg 
    1430                 1435                 1440             


Ile Gln  Asn Ile Leu Thr Glu  Glu Pro Lys Val Thr  Gln Val Tyr 
    1445                 1450                 1455             


Ala Glu  Asn Gly Thr Val Leu  Gln Gly Ser Thr Val  Ala Ser Val 
    1460                 1465                 1470             


Tyr Lys  Gly Lys Leu Leu Ile  Gly Thr Val Phe His  Lys Ala Leu 
    1475                 1480                 1485             


Tyr Cys  Glu Leu 
    1490         


<210>  90
<211>  2041
<212>  DNA
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1 DNA

<400>  90
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc tctccggagg aggtggctca      840

ggtggtggag gatctggagg aggtgggagt ggtggaggtg gttctaccgg tctcgagccc      900

aaatcttctg acaaaactca cacatctcca ccgtccccag cacctgaact cctgggagga      960

tcgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1020

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1080

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1140

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1200

gagtacaagt gcaaggtctc caacaaagcc ctcccagcct ccatcgagaa aaccatctcc     1260

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     1320

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1380

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1440

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1500

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1560

cagaagagcc tctctctctc tccgggtaaa gtcgacggag ctagcagccc cgtgaacgtg     1620

agcagcccca gcgtgcagga tatcaaggaa tcccgggcca agaaattcca gcggcagcat     1680

atggactcag acagttcccc cagcagcagc tccacctact gtaaccaaat gatgaggcgc     1740

cggaatatga cacaggggcg gtgcaaacca gtgaacacct ttgtgcacga gcccctggta     1800

gatgtccaga atgtctgttt ccaggaaaag gtcacctgca agaacgggca gggcaactgc     1860

tacaagagca actccagcat gcacatcaca gactgccgcc tgacaaacgg ctccaggtac     1920

cccaactgtg cataccggac cagcccgaag gagagacaca tcattgtggc ctgtgaaggg     1980

agcccatatg tgccagtcca ctttgatgct tctgtggagg actctaccta ataatctaga     2040

a                                                                     2041


<210>  91
<211>  671
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1

<400>  91

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Lys 
    530                 535                 540                 


Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser 
545                 550                 555                 560 


Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg 
                565                 570                 575     


Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu 
            580                 585                 590         


Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys 
        595                 600                 605             


Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile 
    610                 615                 620                 


Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr 
625                 630                 635                 640 


Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser 
                645                 650                 655     


Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
            660                 665                 670     


<210>  92
<211>  671
<212>  PRT
<213>  Artificial

<220>
<223>  hWTAPO1-(g4s)4-mthIgG-hRNase1 with proline at Eu position 331 in 
       Fc region

<400>  92

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser 
    290                 295                 300                 


Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu 
305                 310                 315                 320 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                325                 330                 335     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            340                 345                 350         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        355                 360                 365             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    370                 375                 380                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
385                 390                 395                 400 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                405                 410                 415     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            420                 425                 430         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        435                 440                 445             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    450                 455                 460                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
465                 470                 475                 480 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                485                 490                 495     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            500                 505                 510         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly 
        515                 520                 525             


Ala Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Lys 
    530                 535                 540                 


Glu Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser 
545                 550                 555                 560 


Ser Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg 
                565                 570                 575     


Asn Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu 
            580                 585                 590         


Pro Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys 
        595                 600                 605             


Lys Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile 
    610                 615                 620                 


Thr Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr 
625                 630                 635                 640 


Arg Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser 
                645                 650                 655     


Pro Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
            660                 665                 670     


<210>  93
<211>  2806
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-RNase1 DNA

<400>  93
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct accggtctcg agcccaaatc ttctgacaaa     1680

actcacacat ctccaccgtc cccagcacct gaactcctgg gaggatcgtc agtcttcctc     1740

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1800

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1860

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1920

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1980

gtctccaaca aagccctccc agcctccatc gagaaaacca tctccaaagc caaagggcag     2040

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     2100

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     2160

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     2220

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2280

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctct     2340

ctctctccgg gtaaagtcga cggagctagc agccccgtga acgtgagcag ccccagcgtg     2400

caggatatca aggaatcccg ggccaagaaa ttccagcggc agcatatgga ctcagacagt     2460

tcccccagca gcagctccac ctactgtaac caaatgatga ggcgccggaa tatgacacag     2520

gggcggtgca aaccagtgaa cacctttgtg cacgagcccc tggtagatgt ccagaatgtc     2580

tgtttccagg aaaaggtcac ctgcaagaac gggcagggca actgctacaa gagcaactcc     2640

agcatgcaca tcacagactg ccgcctgaca aacggctcca ggtaccccaa ctgtgcatac     2700

cggaccagcc cgaaggagag acacatcatt gtggcctgtg aagggagccc atatgtgcca     2760

gtccactttg atgcttctgt ggaggactct acctaataat ctagaa                    2806


<210>  94
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc-L3-RNase1 polypeptide

<400>  94

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Thr Gly Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro 
545                 550                 555                 560 


Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Val Asp Gly Ala 
    770                 775                 780                 


Ser Ser Pro Val Asn Val Ser Ser Pro Ser Val Gln Asp Ile Lys Glu 
785                 790                 795                 800 


Ser Arg Ala Lys Lys Phe Gln Arg Gln His Met Asp Ser Asp Ser Ser 
                805                 810                 815     


Pro Ser Ser Ser Ser Thr Tyr Cys Asn Gln Met Met Arg Arg Arg Asn 
            820                 825                 830         


Met Thr Gln Gly Arg Cys Lys Pro Val Asn Thr Phe Val His Glu Pro 
        835                 840                 845             


Leu Val Asp Val Gln Asn Val Cys Phe Gln Glu Lys Val Thr Cys Lys 
    850                 855                 860                 


Asn Gly Gln Gly Asn Cys Tyr Lys Ser Asn Ser Ser Met His Ile Thr 
865                 870                 875                 880 


Asp Cys Arg Leu Thr Asn Gly Ser Arg Tyr Pro Asn Cys Ala Tyr Arg 
                885                 890                 895     


Thr Ser Pro Lys Glu Arg His Ile Ile Val Ala Cys Glu Gly Ser Pro 
            900                 905                 910         


Tyr Val Pro Val His Phe Asp Ala Ser Val Glu Asp Ser Thr 
        915                 920                 925     


<210>  95
<211>  2398
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc DNA

<400>  95
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ttggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct ggaggaggtg gtagtggagg tggaggttct     1680

accggtctcg agcccaaatc ttctgacaaa actcacacat ctccaccgtc cccagcacct     1740

gaactcctgg gaggatcgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1800

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1860

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1920

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1980

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcctccatc     2040

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     2100

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     2160

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     2220

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2280

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2340

cacaaccact acacgcagaa gagcctctct ctctctccgg gtaaatgata atctagaa       2398


<210>  96
<211>  790
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc polypeptide

<400>  96

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
545                 550                 555                 560 


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
                565                 570                 575     


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            580                 585                 590         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        595                 600                 605             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    610                 615                 620                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
625                 630                 635                 640 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                645                 650                 655     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            660                 665                 670         


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        675                 680                 685             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    690                 695                 700                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
705                 710                 715                 720 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                725                 730                 735     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            740                 745                 750         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        755                 760                 765             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    770                 775                 780                 


Ser Leu Ser Pro Gly Lys 
785                 790 


<210>  97
<211>  2398
<212>  DNA
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc DNA

<400>  97
gttaagcttg ccaccatgaa agctgcggtg ctgaccttgg ccgtgctctt cctgacgggg       60

agccaggctc ggcatttctg gcagcaagat gaaccccccc agagcccctg ggatcgagtg      120

aaggacctgg ccactgtgta cgtggatgtg ctcaaagaca gcggcagaga ctatgtgtcc      180

cagtttgaag gctccgcctt gggaaaacag ctaaacctaa agctccttga caactgggac      240

agcgtgacct ccaccttcag caagctgcgc gaacagctcg gccctgtgac ccaggagttc      300

tgggataacc tggaaaagga gacagagggc ctgaggcagg agatgagcaa ggatctggag      360

gaggtgaagg ccaaggtgca gccctacctg gacgacttcc agaagaagtg gcaggaggag      420

atggagctct accgccagaa ggtggagccg ctgcgcgcag agctccaaga gggcgcgcgc      480

cagaagctgc acgagctgca agagaagctg agcccactgg gcgaggagat gcgcgaccgc      540

gcgcgcgccc atgtggacgc gctgcgcacg catctggccc cctacagcga cgagctgcgc      600

cagcgcttgg ccgcgcgcct tgaggctctc aaggagaacg gcggcgccag actggccgag      660

taccacgcca aggccaccga gcatctgagc acgctcagcg agaaggccaa gcccgcgctc      720

gaggacctcc gccaaggcct gctgcccgtg ctggagagct tcaaggtcag cttcctgagc      780

gctctcgagg agtacactaa gaagctcaac acccaagatc ctggtggagg tggatctggt      840

ggtggaggaa gcgatgaacc cccccagagc ccctgggatc gagtgaagga cctggccact      900

gtgtacgtgg atgtgctcaa agacagcggc agagactatg tgtcccagtt tgaaggctcc      960

gccttgggaa aacagctaaa cctaaagctc cttgacaact gggacagcgt gacctccacc     1020

ttcagcaagc tgcgcgaaca gctcggccct gtgacccagg agttctggga taacctggaa     1080

aaggagacag agggcctgag gcaggagatg agcaaggatc tggaggaggt gaaggccaag     1140

gtgcagccct acctggacga cttccagaag aagtggcagg aggagatgga gctctaccgc     1200

cagaaggtgg agccgctgcg cgcagagctc caagagggcg cgcgccagaa gctgcacgag     1260

ctgcaagaga agctgagccc actgggcgag gagatgcgcg accgcgcgcg cgcccatgtg     1320

gacgcgctgc gcacgcatct ggccccctac agcgacgagc tgcgccagcg cttggccgcg     1380

cgccttgagg ctctcaagga gaacggcggc gccagactgg ccgagtacca cgccaaggcc     1440

accgagcatc tgagcacgct cagcgagaag gccaagcccg cgctcgagga cctccgccaa     1500

ggcctgctgc ccgtgctgga gagcttcaag gtcagcttcc tgagcgctct cgaggagtac     1560

actaagaagc tcaacaccca agatctctcc ggaggaggtg gctcaggtgg tggaggatct     1620

ggaggaggtg ggagtggtgg aggtggttct ggaggaggtg gtagtggagg tggaggttct     1680

accggtctcg agcccaaatc ttctgacaaa actcacacat ctccaccgtc cccagcacct     1740

gaactcctgg gaggatcgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1800

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1860

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     1920

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1980

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcctccatc     2040

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     2100

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     2160

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     2220

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2280

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     2340

cacaaccact acacgcagaa gagcctctct ctctctccgg gtaaatgata atctagaa       2398


<210>  98
<211>  790
<212>  PRT
<213>  Artificial

<220>
<223>  apoA1-L1-apoA1-L2-Fc polypeptide

<400>  98

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Pro Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Asp Glu Pro Pro Gln Ser Pro Trp Asp 
        275                 280                 285             


Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp Ser 
    290                 295                 300                 


Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys Gln 
305                 310                 315                 320 


Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr Phe 
                325                 330                 335     


Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp Asp 
            340                 345                 350         


Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys Asp 
        355                 360                 365             


Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe Gln 
    370                 375                 380                 


Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu Pro 
385                 390                 395                 400 


Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu Leu 
                405                 410                 415     


Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala Arg 
            420                 425                 430         


Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp Glu 
        435                 440                 445             


Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn Gly 
    450                 455                 460                 


Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu Ser 
465                 470                 475                 480 


Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln Gly 
                485                 490                 495     


Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala Leu 
            500                 505                 510         


Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln Asp Leu Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Gly Leu Glu Pro 
545                 550                 555                 560 


Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu 
                565                 570                 575     


Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            580                 585                 590         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        595                 600                 605             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    610                 615                 620                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
625                 630                 635                 640 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                645                 650                 655     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            660                 665                 670         


Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        675                 680                 685             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    690                 695                 700                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
705                 710                 715                 720 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                725                 730                 735     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            740                 745                 750         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        755                 760                 765             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    770                 775                 780                 


Ser Leu Ser Pro Gly Lys 
785                 790 


