                         SEQUENCE LISTING

<110>  The Secretary of State for Health
 
<120>  Poliovaccine

<130>  P43953WO

<150>  GB 1700825.1
<151>  2017-01-17

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  302
<212>  PRT
<213>  Poliovirus

<400>  1

Gly Leu Gly Gln Met Leu Glu Ser Met Ile Asp Asn Thr Val Arg Glu 
1               5                   10                  15      


Thr Val Gly Ala Ala Thr Ser Arg Asp Ala Leu Pro Asn Thr Glu Ala 
            20                  25                  30          


Ser Gly Pro Thr His Ser Lys Glu Ile Pro Ala Leu Thr Ala Val Glu 
        35                  40                  45              


Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln Thr Arg 
    50                  55                  60                  


His Val Val Gln His Arg Ser Arg Ser Glu Ser Ser Ile Glu Ser Phe 
65                  70                  75                  80  


Phe Ala Arg Gly Ala Cys Val Thr Ile Met Thr Val Asp Asn Pro Ala 
                85                  90                  95      


Ser Thr Thr Asn Lys Asp Lys Leu Phe Ala Val Trp Lys Ile Thr Tyr 
            100                 105                 110         


Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser 
        115                 120                 125             


Arg Phe Asp Met Glu Leu Thr Phe Val Val Thr Ala Asn Phe Thr Glu 
    130                 135                 140                 


Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Val 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Val Pro Glu Lys Trp Asp Asp Tyr Thr Trp Gln 
                165                 170                 175     


Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Thr Ala Pro Ala 
            180                 185                 190         


Arg Ile Ser Val Pro Tyr Val Gly Ile Ser Asn Ala Tyr Ser His Phe 
        195                 200                 205             


Tyr Asp Gly Phe Ser Lys Val Pro Leu Lys Asp Gln Ser Ala Ala Leu 
    210                 215                 220                 


Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly Ile Leu 
225                 230                 235                 240 


Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr Ser Lys 
                245                 250                 255     


Ile Arg Val Tyr Leu Lys Pro Lys His Ile Arg Val Trp Cys Pro Arg 
            260                 265                 270         


Pro Pro Arg Gln Leu Ala Tyr Tyr Gly Pro Gly Val Asp Tyr Lys Asp 
        275                 280                 285             


Gly Thr Leu Thr Pro Leu Ser Thr Lys Asp Leu Thr Thr Tyr 
    290                 295                 300         


<210>  2
<211>  271
<212>  PRT
<213>  Poliovirus

<400>  2

Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg Val Leu Gln Leu 
1               5                   10                  15      


Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala Ala Asn Ser Val 
            20                  25                  30          


Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg Asp Ser Glu Ala Asn 
        35                  40                  45              


Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala Cys Arg Phe Tyr 
    50                  55                  60                  


Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser Arg Gly Trp Trp Trp 
65                  70                  75                  80  


Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu Phe Gly Gln Asn Met 
                85                  90                  95      


Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr Val His Val Gln Cys 
            100                 105                 110         


Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val Phe Ala Val Pro 
        115                 120                 125             


Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr Thr Met His Thr Ser 
    130                 135                 140                 


Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly Thr Phe Thr Gly Thr 
145                 150                 155                 160 


Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala Arg Ser Ser Ala Arg 
                165                 170                 175     


Trp Ile Thr Ser Leu Glu Met Ala Arg Cys Trp Gly Met Pro Leu Cys 
            180                 185                 190         


Ser Ala Gln Ile Ile Asn Leu Arg Thr Asn Asn Cys Ala Thr Leu Val 
        195                 200                 205             


Leu Pro Tyr Val Asn Ser Leu Ser Leu Asp Ser Met Val Lys His Asn 
    210                 215                 220                 


Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro Leu Asn Phe Val Ser 
225                 230                 235                 240 


Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu Thr Ile Ala Pro Met Cys 
                245                 250                 255     


Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Leu Pro Arg Leu Gln 
            260                 265                 270     


<210>  3
<211>  237
<212>  PRT
<213>  Poliovirus

<400>  3

Gly Leu Pro Val Met Asn Thr Pro Gly Ser Asn Gln Tyr Leu Thr Ala 
1               5                   10                  15      


Asp Asn Phe Gln Ser Pro Cys Ala Leu Pro Glu Phe Asp Val Thr Pro 
            20                  25                  30          


Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met Leu Ala Glu Ile 
        35                  40                  45              


Asp Thr Met Ile Pro Phe Asp Leu Ser Ala Thr Lys Lys Asn Thr Met 
    50                  55                  60                  


Glu Met Tyr Arg Val Arg Leu Ser Asp Lys Pro His Thr Ala Ala Ser 
65                  70                  75                  80  


Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp Pro Arg Leu Ser His 
                85                  90                  95      


Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr His Trp Ala Gly Ser 
            100                 105                 110         


Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met Met Ala Thr Gly Lys 
        115                 120                 125             


Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Asp Pro Pro Lys Lys Arg 
    130                 135                 140                 


Lys Glu Ala Met Leu Gly Thr His Val Ile Trp Asp Ile Gly Leu Gln 
145                 150                 155                 160 


Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser Asn Ser Thr Tyr Arg 
                165                 170                 175     


Gln Thr Ile Asp Asp Ser Phe Thr Glu Gly Gly Tyr Ile Ser Val Phe 
            180                 185                 190         


Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr Pro Arg Glu Met Asp 
        195                 200                 205             


Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Leu Leu 
    210                 215                 220                 


Arg Asp Thr Thr His Ile Glu Gln Lys Ala Leu Ala Gln 
225                 230                 235         


<210>  4
<211>  68
<212>  PRT
<213>  Poliovirus

<400>  4

Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser Asn 
1               5                   10                  15      


Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr Tyr 
            20                  25                  30          


Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln Asp 
        35                  40                  45              


Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr Ala 
    50                  55                  60                  


Pro Met Leu Asn 
65              


<210>  5
<211>  339
<212>  PRT
<213>  Poliovirus

<400>  5

Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser Asn 
1               5                   10                  15      


Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr Tyr 
            20                  25                  30          


Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln Asp 
        35                  40                  45              


Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr Ala 
    50                  55                  60                  


Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg 
65                  70                  75                  80  


Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala 
                85                  90                  95      


Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg Asp 
            100                 105                 110         


Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala 
        115                 120                 125             


Cys Arg Phe Tyr Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser Arg 
    130                 135                 140                 


Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu Phe 
145                 150                 155                 160 


Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr Val 
                165                 170                 175     


His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val 
            180                 185                 190         


Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr Thr 
        195                 200                 205             


Met His Thr Ser Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly Thr 
    210                 215                 220                 


Phe Thr Gly Thr Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala Arg 
225                 230                 235                 240 


Ser Ser Ala Arg Trp Ile Thr Ser Leu Glu Met Ala Arg Cys Trp Gly 
                245                 250                 255     


Met Pro Leu Cys Ser Ala Gln Ile Ile Asn Leu Arg Thr Asn Asn Cys 
            260                 265                 270         


Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Leu Asp Ser Met 
        275                 280                 285             


Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro Leu 
    290                 295                 300                 


Asn Phe Val Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu Thr Ile 
305                 310                 315                 320 


Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Leu Pro 
                325                 330                 335     


Arg Leu Gln 
            


<210>  6
<211>  301
<212>  PRT
<213>  Poliovirus

<400>  6

Gly Leu Gly Asp Leu Ile Glu Gly Val Val Glu Gly Val Thr Arg Asn 
1               5                   10                  15      


Ala Leu Thr Pro Leu Thr Pro Ala Asn Asn Leu Pro Asp Thr Gln Ser 
            20                  25                  30          


Ser Gly Pro Ala His Ser Lys Glu Thr Pro Ala Leu Thr Ala Val Glu 
        35                  40                  45              


Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln Thr Arg 
    50                  55                  60                  


His Val Ile Gln Lys Arg Thr Arg Ser Glu Ser Thr Val Glu Ser Phe 
65                  70                  75                  80  


Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn Asp Ala 
                85                  90                  95      


Pro Thr Lys Arg Ala Ser Lys Leu Phe Ser Val Trp Lys Ile Thr Tyr 
            100                 105                 110         


Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser 
        115                 120                 125             


Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ser Asn Tyr Thr Asp 
    130                 135                 140                 


Ala Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Ile 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Ile Pro Gly Lys Trp Asn Asp Tyr Thr Trp Gln 
                165                 170                 175     


Thr Ser Ser Asn Pro Ser Val Phe Tyr Thr Tyr Gly Ala Pro Pro Ala 
            180                 185                 190         


Arg Ile Ser Val Pro Tyr Val Gly Ile Ala Asn Ala Tyr Ser His Phe 
        195                 200                 205             


Tyr Asp Gly Phe Ala Lys Val Pro Leu Ala Gly Gln Ala Ser Thr Glu 
    210                 215                 220                 


Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly Ser Leu 
225                 230                 235                 240 


Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Leu Thr Ser Lys 
                245                 250                 255     


Ile Arg Val Tyr Met Lys Pro Lys His Val Arg Val Trp Cys Pro Arg 
            260                 265                 270         


Pro Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr Lys Asp 
        275                 280                 285             


Gly Leu Ala Pro Leu Pro Glu Lys Gly Leu Thr Thr Tyr 
    290                 295                 300     


<210>  7
<211>  271
<212>  PRT
<213>  Poliovirus

<400>  7

Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg Val Met Gln Leu 
1               5                   10                  15      


Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala Ala Asn Ser Val 
            20                  25                  30          


Val Ala Tyr Gly Arg Trp Pro Glu Tyr Ile Lys Asp Ser Glu Ala Asn 
        35                  40                  45              


Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala Cys Arg Phe Tyr 
    50                  55                  60                  


Thr Leu Asp Thr Val Thr Trp Arg Lys Glu Ser Arg Gly Trp Trp Trp 
65                  70                  75                  80  


Lys Leu Pro Asp Ala Leu Lys Asp Met Gly Leu Phe Gly Gln Asn Met 
                85                  90                  95      


Phe Tyr His Tyr Leu Gly Arg Ala Gly Tyr Thr Val His Val Gln Cys 
            100                 105                 110         


Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val Phe Ala Val Pro 
        115                 120                 125             


Glu Met Cys Leu Ala Gly Asp Ser Thr Thr His Met Phe Thr Lys Tyr 
    130                 135                 140                 


Glu Asn Ala Asn Pro Gly Glu Lys Gly Gly Glu Phe Lys Gly Ser Phe 
145                 150                 155                 160 


Thr Leu Asp Thr Asn Ala Thr Asn Pro Ala Arg Asn Phe Cys Pro Val 
                165                 170                 175     


Asp Tyr Leu Phe Gly Ser Gly Val Leu Ala Gly Asn Ala Phe Val Tyr 
            180                 185                 190         


Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn Cys Ala Thr Leu Val 
        195                 200                 205             


Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser Met Thr Lys His Asn 
    210                 215                 220                 


Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro Leu Asp Phe Ala Thr 
225                 230                 235                 240 


Glu Ser Ser Thr Glu Ile Pro Ile Thr Leu Thr Ile Ala Pro Met Cys 
                245                 250                 255     


Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Val Pro Arg Thr Gln 
            260                 265                 270     


<210>  8
<211>  238
<212>  PRT
<213>  Poliovirus

<400>  8

Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln Tyr Leu Thr Ala 
1               5                   10                  15      


Asp Asn Tyr Gln Ser Pro Cys Ala Ile Pro Glu Phe Asp Val Thr Pro 
            20                  25                  30          


Pro Ile Asp Ile Pro Gly Glu Val Arg Asn Met Met Glu Leu Ala Glu 
        35                  40                  45              


Ile Asp Thr Met Ile Pro Leu Asn Leu Thr Asn Gln Arg Lys Asn Thr 
    50                  55                  60                  


Met Asp Met Tyr Arg Val Glu Leu Asn Asp Ala Ala His Ser Asp Thr 
65                  70                  75                  80  


Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp Pro Arg Leu Ala 
                85                  90                  95      


His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr His Trp Ala Gly 
            100                 105                 110         


Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met Met Ala Thr Gly 
        115                 120                 125             


Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Glu Ala Pro Lys Ser 
    130                 135                 140                 


Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp Asp Ile Gly Leu 
145                 150                 155                 160 


Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser Asn Thr Thr Tyr 
                165                 170                 175     


Arg Gln Thr Ile Asn Asp Ser Phe Thr Glu Gly Gly Tyr Ile Ser Met 
            180                 185                 190         


Phe Tyr Gln Thr Arg Val Val Val Pro Leu Ser Thr Pro Arg Lys Met 
        195                 200                 205             


Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Leu 
    210                 215                 220                 


Leu Arg Asp Thr Thr His Ile Ser Gln Glu Ala Met Pro Gln 
225                 230                 235             


<210>  9
<211>  69
<212>  PRT
<213>  Poliovirus

<400>  9

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ala Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Thr Leu Asn 
65                  


<210>  10
<211>  271
<212>  PRT
<213>  Poliovirus

<400>  10

Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg Val Met Gln Leu 
1               5                   10                  15      


Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala Ala Asn Ser Val 
            20                  25                  30          


Val Ala Tyr Gly Arg Trp Pro Glu Tyr Ile Lys Asp Ser Glu Ala Asn 
        35                  40                  45              


Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala Cys Arg Phe Tyr 
    50                  55                  60                  


Thr Leu Asp Thr Val Thr Trp Arg Lys Glu Ser Arg Gly Trp Trp Trp 
65                  70                  75                  80  


Lys Leu Pro Asp Ala Leu Lys Asp Met Gly Leu Phe Gly Gln Asn Met 
                85                  90                  95      


Phe Tyr His Tyr Leu Gly Arg Ala Gly Tyr Thr Val His Val Gln Cys 
            100                 105                 110         


Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val Phe Ala Val Pro 
        115                 120                 125             


Glu Met Cys Leu Ala Gly Asp Ser Thr Thr His Met Phe Thr Lys Tyr 
    130                 135                 140                 


Glu Asn Ala Asn Pro Gly Glu Lys Gly Gly Glu Phe Lys Gly Ser Phe 
145                 150                 155                 160 


Thr Leu Asp Thr Asn Ala Thr Asn Pro Ala Arg Asn Phe Cys Pro Val 
                165                 170                 175     


Asp Tyr Leu Phe Gly Ser Gly Val Leu Ala Gly Asn Ala Phe Val Tyr 
            180                 185                 190         


Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn Cys Ala Thr Leu Val 
        195                 200                 205             


Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser Met Thr Lys His Asn 
    210                 215                 220                 


Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro Leu Asp Phe Ala Thr 
225                 230                 235                 240 


Glu Ser Ser Thr Glu Ile Pro Ile Thr Leu Thr Ile Ala Pro Met Cys 
                245                 250                 255     


Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Val Pro Arg Thr Gln 
            260                 265                 270     


<210>  11
<211>  300
<212>  PRT
<213>  Poliovirus

<400>  11

Gly Ile Glu Asp Leu Ile Thr Glu Val Ala Gln Gly Ala Leu Thr Leu 
1               5                   10                  15      


Ser Leu Pro Lys Gln Gln Asp Ser Leu Pro Asp Thr Lys Ala Ser Gly 
            20                  25                  30          


Pro Ala His Ser Lys Glu Val Pro Ala Leu Thr Ala Val Glu Thr Gly 
        35                  40                  45              


Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln Thr Arg His Val 
    50                  55                  60                  


Ile Gln Arg Arg Ser Arg Ser Glu Ser Thr Ile Glu Ser Phe Phe Ala 
65                  70                  75                  80  


Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn Glu Glu Pro Thr 
                85                  90                  95      


Thr Arg Ala Gln Lys Leu Phe Ala Thr Trp Arg Ile Thr Tyr Lys Asp 
            100                 105                 110         


Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser Arg Phe 
        115                 120                 125             


Asp Met Glu Phe Thr Phe Val Val Thr Ala Asn Phe Thr Asn Thr Asn 
    130                 135                 140                 


Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Ile Pro Pro 
145                 150                 155                 160 


Gly Ala Pro Thr Pro Lys Ser Trp Asp Asp Tyr Thr Trp Gln Thr Ser 
                165                 170                 175     


Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Ala Ala Pro Ala Arg Ile 
            180                 185                 190         


Ser Val Pro Tyr Val Gly Leu Ala Asn Ala Tyr Ser His Phe Tyr Asp 
        195                 200                 205             


Gly Phe Ala Lys Val Pro Leu Lys Thr Asp Ala Asn Asp Gln Ile Gly 
    210                 215                 220                 


Asp Ser Leu Tyr Ser Ala Met Thr Val Asp Asp Phe Gly Val Leu Ala 
225                 230                 235                 240 


Ile Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr Ser Lys Val 
                245                 250                 255     


Arg Ile Tyr Met Lys Pro Lys His Val Arg Val Trp Cys Pro Arg Pro 
            260                 265                 270         


Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr Lys Asp Asn 
        275                 280                 285             


Leu Asn Pro Leu Ser Glu Lys Gly Leu Thr Thr Tyr 
    290                 295                 300 


<210>  12
<211>  271
<212>  PRT
<213>  Poliovirus

<400>  12

Ser Pro Asn Val Glu Ala Cys Gly Tyr Ser Asp Arg Val Leu Gln Leu 
1               5                   10                  15      


Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala Ala Asn Ser Val 
            20                  25                  30          


Val Ala Tyr Gly Arg Trp Pro Glu Phe Ile Arg Asp Asp Glu Ala Asn 
        35                  40                  45              


Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Thr Cys Arg Phe Tyr 
    50                  55                  60                  


Thr Leu Asp Thr Val Met Trp Gly Lys Glu Ser Lys Gly Trp Trp Trp 
65                  70                  75                  80  


Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu Phe Gly Gln Asn Met 
                85                  90                  95      


Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr Val His Val Gln Cys 
            100                 105                 110         


Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val Phe Ala Ile Pro 
        115                 120                 125             


Glu Tyr Cys Leu Ala Gly Asp Ser Asp Lys Gln Arg Tyr Thr Ser Tyr 
    130                 135                 140                 


Ala Asn Ala Asn Pro Gly Glu Lys Gly Gly Lys Phe Tyr Ser Gln Phe 
145                 150                 155                 160 


Asn Arg Asp Thr Ala Val Thr Ser Pro Lys Arg Glu Phe Cys Pro Val 
                165                 170                 175     


Asp Tyr Leu Leu Gly Cys Gly Val Leu Leu Gly Asn Ala Phe Val Tyr 
            180                 185                 190         


Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn Ser Ala Thr Ile Val 
        195                 200                 205             


Leu Pro Tyr Val Asn Ala Leu Ala Ile Asp Ser Met Val Lys His Asn 
    210                 215                 220                 


Asn Trp Gly Ile Ala Ile Leu Pro Leu Ser Pro Leu Asp Phe Ala Gln 
225                 230                 235                 240 


Asp Ser Ser Val Glu Ile Pro Ile Thr Val Thr Ile Ala Pro Met Cys 
                245                 250                 255     


Ser Glu Phe Asn Gly Leu Arg Asn Val Thr Ala Pro Lys Phe Gln 
            260                 265                 270     


<210>  13
<211>  238
<212>  PRT
<213>  Poliovirus

<400>  13

Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln Tyr Leu Thr Ser 
1               5                   10                  15      


Asp Asn His Gln Ser Pro Cys Ala Ile Pro Glu Phe Asp Val Thr Pro 
            20                  25                  30          


Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met Glu Leu Ala Glu 
        35                  40                  45              


Ile Asp Thr Met Ile Pro Leu Asn Leu Glu Asn Thr Lys Arg Asn Thr 
    50                  55                  60                  


Met Asp Met Tyr Arg Val Thr Leu Ser Asp Ser Ala Asp Leu Ser Gln 
65                  70                  75                  80  


Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp Pro Arg Leu Ser 
                85                  90                  95      


His Thr Met Leu Gly Glu Val Leu Asn Tyr Tyr Thr His Trp Ala Gly 
            100                 105                 110         


Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met Met Ala Thr Gly 
        115                 120                 125             


Lys Ile Leu Val Ala Tyr Ala Pro Pro Gly Ala Gln Pro Pro Thr Ser 
    130                 135                 140                 


Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp Asp Leu Gly Leu 
145                 150                 155                 160 


Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser Asn Val Thr Tyr 
                165                 170                 175     


Arg Gln Thr Thr Gln Asp Ser Phe Thr Glu Gly Gly Tyr Ile Ser Met 
            180                 185                 190         


Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr Pro Lys Ser Met 
        195                 200                 205             


Ser Met Leu Gly Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Leu 
    210                 215                 220                 


Leu Arg Asp Thr Thr His Ile Ser Gln Ser Ala Leu Pro Gln 
225                 230                 235             


<210>  14
<211>  69
<212>  PRT
<213>  Poliovirus

<400>  14

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Lys Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Tyr Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Leu Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Thr Leu Asn 
65                  


<210>  15
<211>  340
<212>  PRT
<213>  Poliovirus

<400>  15

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Lys Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Tyr Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Leu Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Thr Leu Asn Ser Pro Asn Val Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Phe Ile Arg 
            100                 105                 110         


Asp Asp Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Thr Cys Arg Phe Tyr Thr Leu Asp Thr Val Met Trp Gly Lys Glu Ser 
    130                 135                 140                 


Lys Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Ile Pro Glu Tyr Cys Leu Ala Gly Asp Ser Asp Lys Gln 
        195                 200                 205             


Arg Tyr Thr Ser Tyr Ala Asn Ala Asn Pro Gly Glu Lys Gly Gly Lys 
    210                 215                 220                 


Phe Tyr Ser Gln Phe Asn Arg Asp Thr Ala Val Thr Ser Pro Lys Arg 
225                 230                 235                 240 


Glu Phe Cys Pro Val Asp Tyr Leu Leu Gly Cys Gly Val Leu Leu Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Ser Ala Thr Ile Val Leu Pro Tyr Val Asn Ala Leu Ala Ile Asp Ser 
        275                 280                 285             


Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ser Pro 
    290                 295                 300                 


Leu Asp Phe Ala Gln Asp Ser Ser Val Glu Ile Pro Ile Thr Val Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Ser Glu Phe Asn Gly Leu Arg Asn Val Thr Ala 
                325                 330                 335     


Pro Lys Phe Gln 
            340 


<210>  16
<211>  881
<212>  PRT
<213>  Poliovirus

<400>  16

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg 
            100                 105                 110         


Asp Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Ala Cys Arg Phe Tyr Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser 
    130                 135                 140                 


Arg Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr 
        195                 200                 205             


Thr Met His Thr Ser Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly 
    210                 215                 220                 


Thr Phe Thr Gly Thr Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala 
225                 230                 235                 240 


Arg Arg Phe Cys Pro Val Asp Tyr Leu Leu Gly Asn Gly Thr Leu Leu 
                245                 250                 255     


Gly Asn Ala Phe Val Phe Pro His Gln Ile Ile Asn Leu Arg Thr Asn 
            260                 265                 270         


Asn Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp 
        275                 280                 285             


Ser Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala 
    290                 295                 300                 


Pro Leu Asn Phe Ala Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu 
305                 310                 315                 320 


Thr Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr 
                325                 330                 335     


Leu Pro Arg Leu Gln Gly Leu Pro Val Met Asn Thr Pro Gly Ser Asn 
            340                 345                 350         


Gln Tyr Leu Thr Ala Asp Asn Phe Gln Ser Pro Cys Ala Leu Pro Glu 
        355                 360                 365             


Phe Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met 
    370                 375                 380                 


Met Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Phe Asp Leu Ser Ala 
385                 390                 395                 400 


Thr Lys Lys Asn Thr Met Glu Met Tyr Arg Val Arg Leu Ser Asp Lys 
                405                 410                 415     


Pro His Thr Asp Asp Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser 
            420                 425                 430         


Asp Pro Arg Leu Ser His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr 
        435                 440                 445             


Thr His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser 
    450                 455                 460                 


Met Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala 
465                 470                 475                 480 


Asp Pro Pro Lys Lys Arg Lys Glu Ala Met Leu Gly Thr His Val Ile 
                485                 490                 495     


Trp Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile 
            500                 505                 510         


Ser Asn Thr Thr Tyr Arg Gln Thr Ile Asp Asp Ser Phe Thr Glu Gly 
        515                 520                 525             


Gly Tyr Ile Ser Val Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser 
    530                 535                 540                 


Thr Pro Arg Glu Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp 
545                 550                 555                 560 


Phe Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Glu Gln Lys Ala 
                565                 570                 575     


Leu Ala Gln Gly Leu Gly Gln Met Leu Glu Ser Met Ile Asp Asn Thr 
            580                 585                 590         


Val Arg Glu Thr Val Gly Ala Ala Thr Ser Arg Asp Ala Leu Pro Asn 
        595                 600                 605             


Thr Glu Ala Ser Gly Pro Thr His Ser Lys Glu Ile Pro Ala Leu Thr 
    610                 615                 620                 


Ala Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val 
625                 630                 635                 640 


Gln Thr Arg His Val Val Gln His Arg Ser Arg Ser Glu Ser Ser Ile 
                645                 650                 655     


Glu Ser Phe Phe Ala Arg Gly Ala Cys Val Thr Ile Met Thr Val Asp 
            660                 665                 670         


Asn Pro Ala Ser Thr Thr Asn Lys Asp Lys Leu Phe Ala Val Trp Lys 
        675                 680                 685             


Ile Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe 
    690                 695                 700                 


Thr Tyr Ser Arg Phe Asp Met Glu Leu Thr Phe Val Val Thr Ala Asn 
705                 710                 715                 720 


Phe Thr Glu Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile 
                725                 730                 735     


Met Tyr Val Pro Pro Gly Ala Pro Val Pro Glu Lys Trp Asp Asp Tyr 
            740                 745                 750         


Thr Trp Gln Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Thr 
        755                 760                 765             


Ala Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ser Asn Ala Tyr 
    770                 775                 780                 


Ser His Phe Tyr Asp Gly Phe Ser Lys Val Pro Leu Lys Asp Gln Ser 
785                 790                 795                 800 


Ala Ala Leu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe 
                805                 810                 815     


Gly Ile Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val 
            820                 825                 830         


Thr Ser Lys Ile Arg Val Tyr Leu Lys Pro Lys His Ile Arg Val Trp 
        835                 840                 845             


Cys Pro Arg Pro Pro Arg Ala Val Ala Tyr Tyr Gly Pro Gly Val Asp 
    850                 855                 860                 


Tyr Lys Asp Gly Thr Leu Thr Pro Leu Ser Thr Lys Asp Leu Thr Thr 
865                 870                 875                 880 


Tyr 
    


<210>  17
<211>  881
<212>  PRT
<213>  Poliovirus

<400>  17

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ser Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg 
            100                 105                 110         


Asp Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Ala Cys Arg Phe Tyr Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser 
    130                 135                 140                 


Arg Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr 
        195                 200                 205             


Thr Met His Thr Ser Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly 
    210                 215                 220                 


Thr Phe Thr Gly Thr Phe Thr Pro Asp Asp Asn Gln Thr Ser Pro Ala 
225                 230                 235                 240 


Arg Arg Phe Cys Pro Val Asp Tyr Leu Phe Gly Asn Gly Thr Leu Leu 
                245                 250                 255     


Gly Asn Ala Phe Val Phe Pro His Gln Ile Ile Asn Leu Arg Thr Asn 
            260                 265                 270         


Asn Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp 
        275                 280                 285             


Ser Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala 
    290                 295                 300                 


Pro Leu Asn Phe Ala Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu 
305                 310                 315                 320 


Thr Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr 
                325                 330                 335     


Leu Pro Arg Leu Gln Gly Leu Pro Val Met Asn Thr Pro Gly Ser Asn 
            340                 345                 350         


Gln Tyr Leu Thr Ala Asp Asn Phe Gln Ser Pro Cys Ala Leu Pro Glu 
        355                 360                 365             


Phe Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met 
    370                 375                 380                 


Met Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Phe Asp Leu Ser Ala 
385                 390                 395                 400 


Lys Lys Lys Asn Thr Met Glu Met Tyr Arg Val Arg Leu Ser Asp Lys 
                405                 410                 415     


Pro His Thr Asp Asp Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser 
            420                 425                 430         


Asp Pro Arg Leu Ser His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr 
        435                 440                 445             


Thr His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser 
    450                 455                 460                 


Met Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala 
465                 470                 475                 480 


Asp Pro Pro Lys Lys Arg Lys Glu Ala Met Leu Gly Thr His Val Ile 
                485                 490                 495     


Trp Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile 
            500                 505                 510         


Ser Asn Thr Thr Tyr Arg Gln Thr Ile Asp Asp Ser Phe Thr Glu Gly 
        515                 520                 525             


Gly Tyr Ile Ser Val Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser 
    530                 535                 540                 


Thr Pro Arg Glu Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp 
545                 550                 555                 560 


Phe Ser Val Arg Leu Met Arg Asp Thr Thr His Ile Glu Gln Lys Ala 
                565                 570                 575     


Leu Ala Gln Gly Leu Gly Gln Met Leu Glu Ser Met Ile Asp Asn Thr 
            580                 585                 590         


Val Arg Glu Thr Val Gly Ala Ala Thr Ser Arg Asp Ala Leu Pro Asn 
        595                 600                 605             


Thr Glu Ala Ser Gly Pro Ala His Ser Lys Glu Ile Pro Ala Leu Thr 
    610                 615                 620                 


Ala Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val 
625                 630                 635                 640 


Gln Thr Arg His Val Val Gln His Arg Ser Arg Ser Glu Ser Ser Ile 
                645                 650                 655     


Glu Ser Phe Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Thr Val Asp 
            660                 665                 670         


Asn Ser Ala Ser Thr Lys Asn Lys Asp Lys Leu Phe Ala Val Trp Lys 
        675                 680                 685             


Ile Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe 
    690                 695                 700                 


Thr Tyr Ser Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ala Asn 
705                 710                 715                 720 


Phe Thr Glu Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile 
                725                 730                 735     


Met Tyr Val Pro Pro Gly Ala Pro Val Pro Glu Lys Trp Asp Asp Tyr 
            740                 745                 750         


Thr Trp Gln Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Thr 
        755                 760                 765             


Ala Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ser Asn Ala Tyr 
    770                 775                 780                 


Ser His Phe Tyr Asp Gly Phe Ser Lys Val Pro Leu Lys Asp Gln Ser 
785                 790                 795                 800 


Ala Ala Leu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe 
                805                 810                 815     


Gly Ile Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val 
            820                 825                 830         


Thr Ser Lys Ile Arg Val Tyr Leu Lys Pro Lys His Ile Arg Val Trp 
        835                 840                 845             


Cys Pro Arg Pro Pro Arg Ala Val Ala Tyr Tyr Gly Pro Gly Val Asp 
    850                 855                 860                 


Tyr Lys Asp Gly Thr Leu Thr Pro Leu Ser Thr Lys Asp Leu Thr Thr 
865                 870                 875                 880 


Tyr 
    


<210>  18
<211>  879
<212>  PRT
<213>  Poliovirus

<400>  18

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ala Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Met Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Ile Lys 
            100                 105                 110         


Asp Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Ala Cys Arg Phe Tyr Thr Leu Asp Thr Val Thr Trp Arg Lys Glu Ser 
    130                 135                 140                 


Arg Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Lys Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Phe Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Thr Thr His 
        195                 200                 205             


Met Phe Thr Lys Tyr Glu Asn Ala Asn Pro Gly Glu Lys Gly Gly Glu 
    210                 215                 220                 


Phe Lys Gly Ser Phe Thr Leu Asp Thr Asn Ala Thr Asn Pro Ala Arg 
225                 230                 235                 240 


Asn Phe Cys Pro Val Asp Tyr Leu Phe Gly Ser Gly Val Leu Ala Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser 
        275                 280                 285             


Met Thr Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro 
    290                 295                 300                 


Leu Asp Phe Ala Thr Glu Ser Ser Thr Glu Ile Pro Ile Thr Leu Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Val 
                325                 330                 335     


Pro Arg Thr Gln Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ala Asp Asn Tyr Gln Ser Pro Cys Ala Ile Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Arg Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Leu Asn Leu Thr Asn Gln 
385                 390                 395                 400 


Arg Lys Asn Thr Met Asp Met Tyr Arg Val Glu Leu Asn Asp Ala Ala 
                405                 410                 415     


His Ser Asp Thr Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp 
            420                 425                 430         


Pro Arg Leu Ala His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Glu 
465                 470                 475                 480 


Ala Pro Lys Ser Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Thr Thr Tyr Arg Gln Thr Ile Asn Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Met Phe Tyr Gln Thr Arg Val Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Arg Lys Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Ser Gln Glu Ala Met 
                565                 570                 575     


Pro Gln Gly Leu Gly Asp Leu Ile Glu Gly Val Val Glu Gly Val Thr 
            580                 585                 590         


Arg Asn Ala Leu Thr Pro Leu Thr Pro Ala Asn Asn Leu Pro Asp Thr 
        595                 600                 605             


Gln Ser Ser Gly Pro Ala His Ser Lys Glu Thr Pro Ala Leu Thr Ala 
    610                 615                 620                 


Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln 
625                 630                 635                 640 


Thr Arg His Val Ile Gln Lys Arg Thr Arg Ser Glu Ser Thr Val Glu 
                645                 650                 655     


Ser Phe Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn 
            660                 665                 670         


Asp Ala Pro Thr Lys Arg Ala Ser Lys Leu Phe Ser Val Trp Lys Ile 
        675                 680                 685             


Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr 
    690                 695                 700                 


Tyr Ser Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ser Asn Tyr 
705                 710                 715                 720 


Thr Asp Ala Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met 
                725                 730                 735     


Tyr Ile Pro Pro Gly Ala Pro Ile Pro Gly Lys Trp Asn Asp Tyr Thr 
            740                 745                 750         


Trp Gln Thr Ser Ser Asn Pro Ser Val Phe Tyr Thr Tyr Gly Ala Pro 
        755                 760                 765             


Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ala Asn Ala Tyr Ser 
    770                 775                 780                 


His Phe Tyr Asp Gly Phe Ala Lys Val Pro Leu Ala Gly Gln Ala Ser 
785                 790                 795                 800 


Thr Glu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly 
                805                 810                 815     


Ser Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Leu Thr 
            820                 825                 830         


Ser Lys Ile Arg Val Tyr Met Lys Pro Lys His Val Arg Val Trp Cys 
        835                 840                 845             


Pro Arg Pro Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr 
    850                 855                 860                 


Lys Asp Gly Leu Ala Pro Leu Pro Glu Lys Gly Leu Thr Thr Tyr 
865                 870                 875                 


<210>  19
<211>  880
<212>  PRT
<213>  Poliovirus

<400>  19

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ala Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Ile Arg 
            100                 105                 110         


Asp Thr Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Ala Cys Arg Phe Tyr Thr Leu Asp Thr Val Thr Trp Arg Lys Glu Ser 
    130                 135                 140                 


Arg Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Lys Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Phe Tyr His Tyr Leu Gly Arg Ala Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Thr Thr His 
        195                 200                 205             


Met Phe Thr Lys Tyr Glu Asn Ala Asn Pro Gly Glu Lys Gly Gly Glu 
    210                 215                 220                 


Phe Lys Gly Ser Phe Thr Leu Asp Thr Asn Ala Thr Asn Pro Ala Arg 
225                 230                 235                 240 


Asn Phe Cys Pro Val Asp Tyr Leu Phe Gly Ser Gly Val Leu Val Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser 
        275                 280                 285             


Met Thr Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro 
    290                 295                 300                 


Leu Asp Phe Ala Thr Glu Ser Ser Thr Glu Ile Pro Ile Thr Leu Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Val 
                325                 330                 335     


Pro Arg Thr Gln Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ala Asp Asn Tyr Gln Ser Pro Cys Ala Ile Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Arg Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Leu Asn Leu Thr Ser Gln 
385                 390                 395                 400 


Arg Lys Asn Thr Met Asp Met Tyr Arg Val Glu Leu Ser Asp Thr Ala 
                405                 410                 415     


His Ser Asp Thr Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp 
            420                 425                 430         


Pro Arg Leu Ala His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Glu 
465                 470                 475                 480 


Ala Pro Lys Ser Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Thr Thr Tyr Arg Gln Thr Ile Asn Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Met Phe Tyr Gln Thr Arg Val Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Arg Lys Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Ser Gln Glu Ala Met 
                565                 570                 575     


Pro Gln Gly Ile Gly Asp Met Ile Glu Gly Ala Val Glu Gly Ile Thr 
            580                 585                 590         


Lys Asn Ala Leu Val Pro Pro Thr Ser Thr Asn Ser Leu Pro Asp Thr 
        595                 600                 605             


Lys Pro Ser Gly Pro Ala His Ser Lys Glu Ile Pro Ala Leu Thr Ala 
    610                 615                 620                 


Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln 
625                 630                 635                 640 


Thr Arg His Val Ile Gln Arg Arg Thr Arg Ser Glu Ser Thr Val Glu 
                645                 650                 655     


Ser Phe Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn 
            660                 665                 670         


Asp Ala Pro Thr Lys Arg Ala Ser Arg Leu Phe Ser Val Trp Lys Ile 
        675                 680                 685             


Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr 
    690                 695                 700                 


Tyr Ser Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ser Asn Tyr 
705                 710                 715                 720 


Ile Asp Ala Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met 
                725                 730                 735     


Tyr Ile Pro Pro Gly Ala Pro Ile Pro Gly Lys Trp Asn Asp Tyr Thr 
            740                 745                 750         


Trp Gln Thr Ser Ser Asn Pro Ser Val Phe Tyr Thr Tyr Gly Ala Pro 
        755                 760                 765             


Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ala Asn Ala Tyr Ser 
    770                 775                 780                 


His Phe Tyr Asp Gly Phe Ala Lys Val Pro Leu Ala Gly Gln Ala Ser 
785                 790                 795                 800 


Thr Glu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly 
                805                 810                 815     


Ser Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Arg Leu Thr 
            820                 825                 830         


Ser Lys Ile Arg Val Tyr Met Lys Pro Lys His Val Arg Val Trp Cys 
        835                 840                 845             


Pro Arg Pro Pro Arg Ala Val Pro Tyr Phe Gly Pro Gly Val Asp Tyr 
    850                 855                 860                 


Lys Asp Gly Thr Leu Thr Pro Leu Pro Glu Lys Gly Leu Thr Thr Tyr 
865                 870                 875                 880 


<210>  20
<211>  878
<212>  PRT
<213>  Poliovirus

<400>  20

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Lys Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Tyr Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Leu Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Thr Leu Asn Ser Pro Asn Val Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Phe Ile Arg 
            100                 105                 110         


Asp Asp Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Thr Cys Arg Phe Tyr Thr Leu Asp Thr Val Met Trp Gly Lys Glu Ser 
    130                 135                 140                 


Lys Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Ile Pro Glu Tyr Cys Leu Ala Gly Asp Ser Asp Lys Gln 
        195                 200                 205             


Arg Tyr Thr Ser Tyr Ala Asn Ala Asn Pro Gly Glu Lys Gly Gly Lys 
    210                 215                 220                 


Phe Tyr Ser Gln Phe Asn Arg Asp Thr Ala Val Thr Ser Pro Lys Arg 
225                 230                 235                 240 


Glu Phe Cys Pro Val Asp Tyr Leu Leu Gly Cys Gly Val Leu Leu Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Ser Ala Thr Ile Val Leu Pro Tyr Val Asn Ala Leu Ala Ile Asp Ser 
        275                 280                 285             


Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ser Pro 
    290                 295                 300                 


Leu Asp Phe Ala Gln Asp Ser Ser Val Glu Ile Pro Ile Thr Val Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Ser Glu Phe Asn Gly Leu Arg Asn Val Thr Ala 
                325                 330                 335     


Pro Lys Phe Gln Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ser Asp Asn His Gln Ser Pro Cys Ala Ile Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Leu Asn Leu Glu Asn Thr 
385                 390                 395                 400 


Lys Arg Asn Thr Met Asp Met Tyr Arg Val Thr Leu Ser Asp Ser Ala 
                405                 410                 415     


Asp Leu Ser Gln Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp 
            420                 425                 430         


Pro Arg Leu Ser His Thr Met Leu Gly Glu Val Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Ile Leu Val Ala Tyr Ala Pro Pro Gly Ala Gln 
465                 470                 475                 480 


Pro Pro Thr Ser Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Leu Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Val Thr Tyr Arg Gln Thr Thr Gln Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Met Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Lys Ser Met Ser Met Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Ser Gln Ser Ala Leu 
                565                 570                 575     


Pro Gln Gly Ile Glu Asp Leu Ile Thr Glu Val Ala Gln Gly Ala Leu 
            580                 585                 590         


Thr Leu Ser Leu Pro Lys Gln Gln Asp Ser Leu Pro Asp Thr Lys Ala 
        595                 600                 605             


Ser Gly Pro Ser His Ser Lys Glu Val Pro Ala Leu Thr Ala Val Glu 
    610                 615                 620                 


Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln Thr Arg 
625                 630                 635                 640 


His Val Ile Gln Arg Arg Ser Arg Ser Glu Ser Thr Ile Glu Ser Phe 
                645                 650                 655     


Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn Glu Glu 
            660                 665                 670         


Pro Thr Thr Arg Ala Gln Lys Leu Phe Ala Thr Trp Arg Ile Thr Tyr 
        675                 680                 685             


Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser 
    690                 695                 700                 


Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ala Asn Phe Thr Asn 
705                 710                 715                 720 


Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Ile 
                725                 730                 735     


Pro Pro Gly Ala Pro Thr Pro Lys Ser Trp Asp Asp Tyr Thr Trp Gln 
            740                 745                 750         


Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Ala Ala Pro Ala 
        755                 760                 765             


Arg Ile Ser Val Pro Tyr Val Gly Leu Ala Asn Ala Tyr Ser His Phe 
    770                 775                 780                 


Tyr Asp Gly Phe Ala Lys Val Pro Leu Lys Thr Asp Ala Asn Asp Gln 
785                 790                 795                 800 


Ile Gly Asp Ser Leu Tyr Ser Ala Met Thr Val Asp Asp Phe Gly Val 
                805                 810                 815     


Leu Ala Ile Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr Ser 
            820                 825                 830         


Lys Val Arg Ile Tyr Met Lys Pro Lys His Val Arg Val Trp Cys Pro 
        835                 840                 845             


Arg Pro Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr Lys 
    850                 855                 860                 


Asp Asn Leu Asn Pro Leu Ser Glu Lys Gly Leu Thr Thr Tyr 
865                 870                 875             


<210>  21
<211>  878
<212>  PRT
<213>  Poliovirus

<400>  21

Met Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser 
1               5                   10                  15      


Asn Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr 
            20                  25                  30          


Tyr Lys Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Tyr Ser Gln 
        35                  40                  45              


Asp Pro Ser Lys Phe Thr Glu Pro Leu Lys Asp Val Leu Ile Lys Thr 
    50                  55                  60                  


Ala Pro Ala Leu Asn Ser Pro Asn Val Glu Ala Cys Gly Tyr Ser Asp 
65                  70                  75                  80  


Arg Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95      


Ala Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Phe Ile Arg 
            100                 105                 110         


Asp Asp Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala 
        115                 120                 125             


Thr Cys Arg Phe Tyr Thr Leu Asp Thr Val Met Trp Gly Lys Glu Ser 
    130                 135                 140                 


Lys Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu 
145                 150                 155                 160 


Phe Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr 
                165                 170                 175     


Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly 
            180                 185                 190         


Val Phe Ala Ile Pro Glu Tyr Cys Leu Ala Gly Asp Ser Asp Lys Gln 
        195                 200                 205             


Arg Tyr Thr Ser Tyr Ala Asn Ala Asn Pro Gly Glu Arg Gly Gly Lys 
    210                 215                 220                 


Phe Tyr Ser Gln Phe Asn Lys Asp Asn Ala Val Thr Ser Pro Lys Arg 
225                 230                 235                 240 


Glu Phe Cys Pro Val Asp Tyr Leu Leu Gly Cys Gly Val Leu Leu Gly 
                245                 250                 255     


Asn Ala Phe Val Tyr Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Ser Ala Thr Ile Val Leu Pro Tyr Val Asn Ser Leu Ala Ile Asp Ser 
        275                 280                 285             


Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ser Pro 
    290                 295                 300                 


Leu Asp Phe Ala Gln Asp Ser Ser Val Glu Ile Pro Ile Thr Val Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Ser Glu Phe Asn Gly Leu Arg Asn Val Thr Ala 
                325                 330                 335     


Pro Lys Phe Gln Gly Leu Pro Val Leu Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ser Asp Asn His Gln Ser Pro Cys Ala Ile Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Leu Asn Leu Glu Ser Thr 
385                 390                 395                 400 


Lys Arg Asn Thr Met Asp Met Tyr Arg Val Thr Leu Ser Asp Ser Ala 
                405                 410                 415     


Asp Leu Ser Gln Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Phe Asp 
            420                 425                 430         


Pro Arg Leu Ser His Thr Met Leu Gly Glu Val Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Ser Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Ile Leu Val Ala Tyr Ala Pro Pro Gly Ala Gln 
465                 470                 475                 480 


Pro Pro Thr Ser Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Leu Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Val Thr Tyr Arg Gln Thr Thr Gln Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Met Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Lys Ser Met Ser Met Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Ser Gln Ser Ala Leu 
                565                 570                 575     


Pro Gln Gly Ile Glu Asp Leu Ile Ser Glu Val Ala Gln Gly Ala Leu 
            580                 585                 590         


Thr Leu Ser Leu Pro Lys Gln Gln Asp Ser Leu Pro Asp Thr Lys Ala 
        595                 600                 605             


Ser Gly Pro Ala His Ser Lys Glu Val Pro Ala Leu Thr Ala Val Glu 
    610                 615                 620                 


Thr Gly Ala Thr Asn Pro Leu Ala Pro Ser Asp Thr Val Gln Thr Arg 
625                 630                 635                 640 


His Val Val Gln Arg Arg Ser Arg Ser Glu Ser Thr Ile Glu Ser Phe 
                645                 650                 655     


Phe Ala Arg Gly Ala Cys Val Ala Ile Ile Glu Val Asp Asn Glu Gln 
            660                 665                 670         


Pro Thr Thr Arg Ala Gln Lys Leu Phe Ala Met Trp Arg Ile Thr Tyr 
        675                 680                 685             


Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser 
    690                 695                 700                 


Arg Phe Asp Met Glu Phe Thr Phe Val Val Thr Ala Asn Phe Thr Asn 
705                 710                 715                 720 


Ala Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Ile 
                725                 730                 735     


Pro Pro Gly Ala Pro Thr Pro Lys Ser Trp Asp Asp Tyr Thr Trp Gln 
            740                 745                 750         


Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Ala Ala Pro Ala 
        755                 760                 765             


Arg Ile Ser Val Pro Tyr Val Gly Leu Ala Asn Ala Tyr Ser His Phe 
    770                 775                 780                 


Tyr Asp Gly Phe Ala Lys Val Pro Leu Lys Thr Asp Ala Asn Asp Gln 
785                 790                 795                 800 


Ile Gly Asp Ser Leu Tyr Ser Ala Met Thr Val Asp Asp Phe Gly Val 
                805                 810                 815     


Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr Ser 
            820                 825                 830         


Lys Val Arg Ile Tyr Met Lys Pro Lys His Val Arg Val Trp Cys Pro 
        835                 840                 845             


Arg Pro Pro Arg Ala Val Pro Tyr Tyr Gly Pro Gly Val Asp Tyr Arg 
    850                 855                 860                 


Asn Asn Leu Asp Pro Leu Ser Glu Lys Gly Leu Thr Thr Tyr 
865                 870                 875             


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1F

<400>  22
gcgagttgga ttggccatcc agtg                                              24


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer P1R

<400>  23
tggaaggtgg gtcccacaaa cgac                                              24


