                         SEQUENCE LISTING

<110>  Pieris Pharmaceuticals GmbH
 
<120>  Lipocalin muteins with binding affinity for LAG-3

<130>  PIE15921PCT

<150>  EP17151945.7
<151>  2017-01-18

<160>  106   

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1

His His Leu Leu Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr 
1               5                   10                  15      


Trp Tyr Leu Lys Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn 
            20                  25                  30          


Leu Glu Ser Val Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn 
        35                  40                  45              


Leu Glu Ala Lys Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val 
    50                  55                  60                  


Lys Ala Val Leu Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp 
65                  70                  75                  80  


Gly Gly Lys His Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His 
                85                  90                  95      


Tyr Ile Phe Tyr Cys Glu Gly Glu Leu His Gly Lys Pro Val Arg Gly 
            100                 105                 110         


Val Lys Leu Val Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu 
        115                 120                 125             


Asp Phe Glu Lys Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile 
    130                 135                 140                 


Leu Ile Pro Arg Gln Ser Glu Thr Cys Ser Pro Gly Ser Asp 
145                 150                 155             


<210>  2
<211>  659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LAG-3 Fc fusion protein

<400>  2

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu Ile Glu Gly Arg Met Asp Pro Lys Ser Cys 
            420                 425                 430         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
        435                 440                 445             


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    450                 455                 460                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
465                 470                 475                 480 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                485                 490                 495     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            500                 505                 510         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        515                 520                 525             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    530                 535                 540                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
545                 550                 555                 560 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                565                 570                 575     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            580                 585                 590         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr Pro Pro 
        595                 600                 605             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    610                 615                 620                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
625                 630                 635                 640 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                645                 650                 655     


Pro Gly Lys 
            


<210>  3
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  3

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Glu Cys Pro Glu Met Asn Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Leu Ile Ser Gly Arg Ser Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys His Gly Lys Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  4
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  4

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Arg Glu Phe Pro Glu Met Asn Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Leu Ile Ser Gly Arg Cys Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Leu His Gly Lys Pro Val Arg Gly Val Lys Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  5
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lag-3 antibody heavy chain

<400>  5

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lag-3 antibody light chain

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  7

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  8
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  8

Thr Ser Asp Gln Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly Pro 
145                 150             


<210>  9
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  9

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Asp Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Gly Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  10
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  10

Ala Ser Gly Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Asp Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Trp 
    130                 135                 140                 


Gln Ser Glu Pro Ser Ser Pro Gly Pro 
145                 150             


<210>  11
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  11

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Ala Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Thr Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His His Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  12
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  12

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Asp Ala Tyr Ile Ile Ser Ser His Val Lys Asp Asn Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Gln Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  13
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  13

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Met Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr His Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ser Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  14
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  14

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  15
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  15

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  16
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  16

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Asn Arg Ser His Val Lys Asp His Tyr Val Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  17
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  17

Ala Ser Asp Glu Glu Phe Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Ala Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Asn Arg Ser His Glu Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly Pro 
145                 150             


<210>  18
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  18

Thr Ser Asp Gln Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly Pro 
145                 150             


<210>  19
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  19

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Met Met Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  20
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  20

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Asp Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly His Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  21
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  21

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Glu Glu Asp Pro Glu Leu Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  22
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  22

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Glu Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Glu Gly Thr Pro Gly Arg Val Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  23
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  23

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Asp Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Leu Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  24
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  24

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Ser Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  25
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  25

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Ala Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Lys Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  26
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  26

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Arg Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Asn Arg Met Ala Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  27
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  27

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Gly Glu Asp Pro Glu Leu Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Tyr 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Pro Gly Thr Pro Gly Arg Met Val Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  28
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  28

Ala Ser Asp Glu Glu Ile Gln Asp Val Pro Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Ser Asp Glu Asp Pro Glu Met Thr Leu Glu Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Arg 
        35                  40                  45              


Val Thr Val Leu Ile Asp Gly Arg Cys Gln Glu Val Lys Asn Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Glu Asp Gly Gly Lys Leu 
65                  70                  75                  80  


Val Asp Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Phe Glu Gly Glu Gly Gln Gly Thr Pro Gly Arg Met Leu Ala Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Thr Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  29
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  29
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc catgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc aggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  30
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  30
acctcagact aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccagggcca                             459


<210>  31
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  31
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaagacggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgagccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagggcga aaccagctct ccagggcca                             459


<210>  32
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  32
gcctcaggcg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gatgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccct ggcagagcga acccagctct ccagggcca                             459


<210>  33
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  33
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggccacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata cgaccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcatcaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccagggcca                             459


<210>  34
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  34
gcctcagacg aggagattca ggatgtgtct gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaagtata cggccgatgg cggcaaacat      240

gatgcctata tcattagcag tcatgtgaaa gataattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaaccag      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccagggcca                             459


<210>  35
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  35
gcctcagacg aggagattca ggatgtgtca gggatgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactacccat      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gtggcctata tcagtcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccagggcca                             459


<210>  36
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  36
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata ccgccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aaccagctct ccagggcca                             459


<210>  37
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  37
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaggac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccagggcca                             459


<210>  38
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  38
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagaaaagac agatgaaccg ggtaaatata cggccggtgg cggcaaacat      240

gttgcctata tcaatcgcag ccatgtgaaa gatcattacg tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagtatc      420

ctcatcccca ggcagagcga aaccagctct ccagggcca                             459


<210>  39
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  39
gcctcagacg aggagtttca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgcaccg ggtaaatata cagccgatgg aggcaaacat      240

gttgcctata tcaatcgcag ccatgagaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggtacc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccagggcca                             459


<210>  40
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  40
acctcagacc aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccagggcca                             459


<210>  41
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  41
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

tcgggggaag atcctgagat gatgctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tcgtgtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaatgtgc tcgagaagac agatgaaccg ggtaaataca cggaggatgg cggcaaacat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

gggcagggca cgccgggtcg catggtggct ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  42
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  42
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcgatgaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccatggca ccccggggag gatggtggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  43
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  43
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcgaggaag atccggaatt gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccagggca ccccgggtag gatggtggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  44
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  44
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcgaggaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggcgagggca ccccggggag ggtggtggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  45
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  45
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcgatgaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccagggca ccccggggag gttggtggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  46
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  46
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcagtgaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gtgctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccagggca ccccgggtag gatggttgcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  47
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  47
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcgctgaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggcaagggca ccccggggag gatggtggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  48
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  48
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agccgtgaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gttctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaacat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccagggca ccccgaatag gatggcggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  49
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  49
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcggggaag atccggaatt gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gtgctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaatat      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccctggca ccccgggtag gatggtggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  50
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  50
gcctcagacg aggagattca ggatgtgcca gggacgtggt atctgaaagc gatgacggtt       60

agcgatgaag atccggaaat gaccctggaa tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc tagggtgacc gtgctgattg atggccgctg ccaggaagtg      180

aaaaacgtgc tcgagaagac agatgaaccg ggtaaataca cggaagatgg cggcaaactt      240

gtggattata tcattagatc tcatgtgaaa gatcattaca tcttctactt tgaaggcgaa      300

ggccagggca ccccgggtag gatgctggcc ctggtgggca gagaccccac caataatctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  51
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  51

His His Leu Leu 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Factor Xa cleavage site

<400>  52

Ile Glu Gly Arg 
1               


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SA linker and strep-tag II fusion peptide

<400>  53

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep-tag II peptide

<400>  54

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3 Linker

<400>  55

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  56
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynoLAG-3 Fc fusion protein

<400>  56

Pro Gln Pro Gly Ala Glu Ile Ser Val Val Trp Ala Gln Glu Gly Ala 
1               5                   10                  15      


Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser 
            20                  25                  30          


Leu Leu Arg Arg Ala Gly Val Thr Trp Gln His Gln Pro Asp Ser Gly 
        35                  40                  45              


Pro Pro Ala Pro Ala Pro Gly His Pro Pro Val Pro Gly His Arg Pro 
    50                  55                  60                  


Ala Ala Pro Tyr Ser Trp Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu 
65                  70                  75                  80  


Ser Val Gly Pro Gly Gly Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro 
                85                  90                  95      


Arg Val Gln Leu Asp Glu Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu 
            100                 105                 110         


Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala Gly Glu Tyr Arg Ala Thr 
        115                 120                 125             


Val His Leu Arg Asp Arg Ala Leu Ser Cys Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Gly Gln Ala Ser Met Thr Ala Ser Pro Pro Gly Ser Leu Arg Thr Ser 
145                 150                 155                 160 


Asp Trp Val Ile Leu Asn Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala 
                165                 170                 175     


Ser Val His Trp Phe Arg Ser Arg Gly Gln Gly Arg Val Pro Val Gln 
            180                 185                 190         


Gly Ser Pro His His His Leu Ala Glu Ser Phe Leu Phe Leu Pro His 
        195                 200                 205             


Val Gly Pro Met Asp Ser Gly Leu Trp Gly Cys Ile Leu Thr Tyr Arg 
    210                 215                 220                 


Asp Gly Phe Asn Val Ser Ile Met Tyr Asn Leu Thr Val Leu Gly Leu 
225                 230                 235                 240 


Glu Pro Ala Thr Pro Leu Thr Val Tyr Ala Gly Ala Gly Ser Arg Val 
                245                 250                 255     


Glu Leu Pro Cys Arg Leu Pro Pro Ala Val Gly Thr Gln Ser Phe Leu 
            260                 265                 270         


Thr Ala Lys Trp Ala Pro Pro Gly Gly Gly Pro Asp Leu Leu Val Ala 
        275                 280                 285             


Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu Glu Asp Val Ser Gln Ala 
    290                 295                 300                 


Gln Ala Gly Thr Tyr Ile Cys His Ile Arg Leu Gln Gly Gln Gln Leu 
305                 310                 315                 320 


Asn Ala Thr Val Thr Leu Ala Ile Ile Thr Val Thr Pro Lys Ser Phe 
                325                 330                 335     


Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu Cys Glu Val Thr Pro Ala 
            340                 345                 350         


Ser Gly Gln Glu His Phe Val Trp Ser Pro Leu Asn Thr Pro Ser Gln 
        355                 360                 365             


Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu 
    370                 375                 380                 


Ser Gln Pro Trp Gln Cys Gln Leu His Gln Gly Glu Arg Leu Leu Gly 
385                 390                 395                 400 


Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser 
                405                 410                 415     


Gly Arg Ala Pro Gly Ala Leu Arg Ala Gly His Leu Ile Glu Gly Arg 
            420                 425                 430         


Met Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        435                 440                 445             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    450                 455                 460                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
465                 470                 475                 480 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                485                 490                 495     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            500                 505                 510         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        515                 520                 525             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    530                 535                 540                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
545                 550                 555                 560 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                565                 570                 575     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            580                 585                 590         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        595                 600                 605             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    610                 615                 620                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
625                 630                 635                 640 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                645                 650                 655     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            660                 665                 670         


Ser Pro Gly Lys 
        675     


<210>  57
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  57

Thr Ser Asp Gln Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  58
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  58

Thr Ser Asn Gln Gln Ile Gln Asn Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asn Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asn His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  59
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  59

Thr Ser Arg Gln Arg Ile Gln Arg Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Arg Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Arg His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  60
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  60

Thr Ser Lys Gln Lys Ile Gln Lys Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Lys Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Lys His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  61
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  61

Thr Ser Asn Gln Gln Ile Gln Asn Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  62
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  62

Thr Ser Asn Gln Gln Ile Gln Asn Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asn Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  63
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  63

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  64
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  64

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Cys Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  65
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  65

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  66
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  66

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Arg Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Arg Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  67
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  67

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Cys Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  68
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  68

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  69
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  69

Ala Ser Asp Glu Glu Ile Gln Asn Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  70
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  70

Ala Ser Asp Glu Glu Ile Gln Asn Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Cys Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Cys Ser Pro Gly 
145                 150         


<210>  71
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  71
acctcagacc aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

cgcggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac agatcgcccg ggtaaatata cggccggcgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


<210>  72
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  72
acctcaaacc agcagattca gaacgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

cgcggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac aaaccgcccg ggtaaatata cggccggcgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa aaccattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


<210>  73
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  73
acctcacgtc agcgtattca gcgtgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

cgcggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac acgtcgcccg ggtaaatata cggccggcgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa aaccattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


<210>  74
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  74
acctcaaaac agaaaattca gaaagtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

cgcggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac aaaacgcccg ggtaaatata cggccggcgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa aaacattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


<210>  75
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  75
acctcagacc aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg ccaggaagtg      180

gaagcagtgt tagggaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgcgct ccaggg                                456


<210>  76
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  76
acctcagacc aggagattca gaatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


<210>  77
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  77
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

cgcggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaggac agatcgcccg ggtaaatata cggccggcgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  78
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  78
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg ccaggaagtg      180

gaagcagtgt tagagaggac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aacctgctct ccaggg                                456


<210>  79
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  79
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaggac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  80
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  80
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

cgcggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

gaagcagtgt tagagaagac agatcgcccg ggtaaatata ccgccggcgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aaccagctct ccaggg                                456


<210>  81
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  81
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg ccaggatgtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata ccgccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aacctgctct ccaggg                                456


<210>  82
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  82
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata ccgccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aaccagctct ccaggg                                456


<210>  83
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  83
gcctcagacg aggagattca gaatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata ccgccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aaccagctct ccaggg                                456


<210>  84
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  84
gcctcagacg aggagattca gaatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg ccaggatgtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata ccgccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aacctgctct ccaggg                                456


<210>  85
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  85

Thr Ser Asp Gln Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  86
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  86

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Asp Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Gly Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  87
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  87

Ala Ser Gly Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Asp Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Trp 
    130                 135                 140                 


Gln Ser Glu Pro Ser Ser Pro Gly 
145                 150         


<210>  88
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  88

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Ala Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Thr Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His His Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  89
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  89

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Lys Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Asp Ala Tyr Ile Ile Ser Ser His Val Lys Asp Asn Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Gln Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  90
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  90

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Met Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr His Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ser Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  91
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  91

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Asp Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Leu Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  92
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  92

Ala Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Arg Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  93
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  93

Thr Ser Asp Glu Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Gly Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Asn Arg Ser His Val Lys Asp His Tyr Val Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  94
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  94

Ala Ser Asp Glu Glu Phe Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Glu Lys Thr Asp Ala Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Val Ala Tyr Ile Asn Arg Ser His Glu Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ser Pro Gly 
145                 150         


<210>  95
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  95

Thr Ser Asp Gln Glu Ile Gln Asp Val Ser Gly Thr Trp Tyr Leu Lys 
1               5                   10                  15      


Ala Met Thr Val Asp Ser Asp Cys Phe Trp Ile Asp Asp Val Ser Val 
            20                  25                  30          


Thr Pro Met Thr Leu Thr Thr Leu Glu Gly Gly Asn Leu Glu Ala Lys 
        35                  40                  45              


Val Thr Met Asp Ile Phe Gly Phe Trp Gln Glu Val Glu Ala Val Leu 
    50                  55                  60                  


Gly Lys Thr Asp Glu Pro Gly Lys Tyr Thr Ala Asp Gly Gly Lys His 
65                  70                  75                  80  


Ala Ala Tyr Ile Ile Arg Ser His Val Lys Asp His Tyr Ile Phe Tyr 
                85                  90                  95      


Ser Glu Gly Glu Cys Ala Gly Tyr Pro Val Pro Gly Val Trp Leu Val 
            100                 105                 110         


Gly Arg Asp Pro Lys Asn Asn Leu Glu Ala Leu Glu Asp Phe Glu Lys 
        115                 120                 125             


Ala Ala Gly Ala Arg Gly Leu Ser Thr Glu Ser Ile Leu Ile Pro Arg 
    130                 135                 140                 


Gln Ser Glu Thr Ser Ala Pro Gly 
145                 150         


<210>  96
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  96
acctcagact aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


<210>  97
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  97
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaagacggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgagccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagggcga aaccagctct ccaggg                                456


<210>  98
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  98
gcctcaggcg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gatgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccct ggcagagcga acccagctct ccaggg                                456


<210>  99
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  99
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggccacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata cgaccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcatcaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  100
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  100
gcctcagacg aggagattca ggatgtgtct gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

aaagcagtgt tagagaagac agatgaaccg ggtaagtata cggccgatgg cggcaaacat      240

gatgcctata tcattagcag tcatgtgaaa gataattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaaccag      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  101
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  101
gcctcagacg aggagattca ggatgtgtca gggatgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactacccat      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gtggcctata tcagtcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  102
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  102
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggatgtg      180

gaagcagtgt tagagaagac agatgaaccg ggtaaatata ccgccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagctgca ggagcccgcg gactcagtac ggagagcatc      420

ctcatcccca ggctgagcga aaccagctct ccaggg                                456


<210>  103
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  103
gcctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaggac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gttgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  104
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  104
acctcagacg aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagaaaagac agatgaaccg ggtaaatata cggccggtgg cggcaaacat      240

gttgcctata tcaatcgcag ccatgtgaaa gatcattacg tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagtatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  105
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  105
gcctcagacg aggagtttca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattctgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagagaagac agatgcaccg ggtaaatata cagccgatgg aggcaaacat      240

gttgcctata tcaatcgcag ccatgagaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggtacc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggactttga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagctct ccaggg                                456


<210>  106
<211>  456
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lipocalin mutein

<400>  106
acctcagacc aggagattca ggatgtgtca gggacgtggt atctgaaggc gatgacggtg       60

gattccgatt gcttttggat tgatgatgtg tcagttacgc caatgactct gactaccctt      120

gaaggcggca atctggaggc taaggtcacc atggatattt ttggcttttg gcaggaagtg      180

gaagcagtgt tagggaagac agatgaaccg ggtaaatata cggccgatgg cggcaaacat      240

gctgcctata tcattcgcag ccatgtgaaa gatcattaca tcttttatag cgagggcgaa      300

tgcgctggct atccggttcc gggggtgtgg ctcgtgggca gagaccccaa gaacaacctg      360

gaagccttgg aggacttcga gaaagccgca ggagcccgcg gactcagcac ggagagcatc      420

ctcatcccca ggcagagcga aaccagcgct ccaggg                                456


