                         SEQUENCE LISTING

<110>  TAYU HUAXIA Biotech Medical Group Co., Ltd.
 
<120>  ANTI-PD-1 ANTIBODIES AND USES THEREOF

<130>  Tayu

<150>  2017100461482
<151>  2017-01-20

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ile Ser His Gly Gly Gly Asp Thr 
1               5               


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr 
1               5                   10                  15      


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Glu Ser Val Asp Tyr Tyr Gly Phe Ser Phe 
1               5                   10  


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is a space filler, not requiring an amino acid

<400>  5

Ala Ala Ser Xaa 
1               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gln Gln Ser Lys Glu Val Pro Trp 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gly Tyr Thr Phe Thr Ser Tyr Thr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Ile Asn Pro Thr Thr Gly Tyr Thr 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Ala Arg Asp Asp Ala Tyr Tyr Ser Gly Tyr 
1               5                   10  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Glu Asn Ile Tyr Ser Asn Leu 
1               5           


<210>  11
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is a space filler, not requiring an amino acid

<400>  11

Ala Ala Lys Xaa 
1               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gln His Phe Trp Gly Thr Pro Trp Thr 
1               5                   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ile Thr Ile Gly Gly Gly Thr Thr 
1               5               


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ala Arg His Arg Tyr Asp Tyr Phe Ala Met Asp Asn 
1               5                   10          


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Glu Asn Val Asp Asn Tyr Gly Ile Asn Phe 
1               5                   10  


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is a space filler, not requiring an amino acid

<400>  17

Val Ser Ser Xaa 
1               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gln Gln Ser Lys Asp Val Pro Trp 
1               5               


<210>  19
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Asn Pro Thr Thr Gly Tyr Thr Asn Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Lys Asp Lys Ala Asn Pro Thr Thr Gly Tyr Thr Asn Tyr Asn Gln 
65                  70                  75                  80  


Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr 
                85                  90                  95      


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Asp Ala Tyr Tyr Ser Gly Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser 
    130                 135 


<210>  20
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
tcccaggtcc agctgcagca gtctggggct gaactggcaa gacctggggc ctcagtgaag       60

atgtcctgca aggcttctgg ctacaccttt actagttaca cgatgcactg ggtaaaacag      120

aggcctggac agggtctgga atggattgga tacattaatc ctactactgg ttatactaat      180

tacaatcaga agttcaagga caaggccaca ttgactgcag acaaatcctc cagcacagcc      240

tacatgcaat tgagcagcct gacatctgag gactctgcag tctattactg tgcaagagat      300

gatgcttact actcgggcta ctggggccaa ggcaccactc tcacagtctc ctca            354


<210>  21
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Arg Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Lys Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  22
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac agtaatttag catggtatcg gcagaaacag      120

ggaaaatctc ctcagctcct ggtctatgct gcaaaaaact tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag tattccctca agatcaacag cctgcagtct      240

gaagattttg ggagttatta ctgtcaacat ttttggggta ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  23
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr Asp 
            20                  25                  30          


Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Val Trp Val Ala 
        35                  40                  45              


Tyr Ile Thr Ile Gly Gly Gly Thr Thr Tyr Tyr Ser Asp Thr Val Lys 
    50                  55                  60                  


Arg Leu Val Trp Val Ala Tyr Ile Thr Ile Gly Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Tyr Ser Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Met Tyr Tyr Cys Ala Arg His Arg Tyr Asp Tyr Phe Ala Met Asp 
        115                 120                 125             


Asn Trp Gly His Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140 


<210>  24
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
gaagtgcagc tggtggagtc ggggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cgctttcagt agctatgaca tgtcttgggt tcgccagact      120

ccggagaaga ggctggtgtg ggtcgcatac attactattg gtggtggcac cacctactat      180

tcagacactg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagacatagg      300

tacgattact tcgctatgga caactggggt catggaacct cagtcaccgt ctcctca         357


<210>  25
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Gly Ala Ala Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Gly 
1               5                   10                  15      


Ala Gly Thr Cys Gly Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr 
            20                  25                  30          


Ala Gly Thr Gly Ala Ala Gly Cys Cys Thr Gly Gly Ala Gly Gly Gly 
        35                  40                  45              


Thr Cys Cys Cys Thr Gly Ala Ala Ala Cys Thr Cys Thr Cys Cys Thr 
    50                  55                  60                  


Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Thr Thr 
65                  70                  75                  80  


Cys Gly Cys Thr Thr Thr Cys Ala Gly Thr Ala Gly Cys Thr Ala Thr 
                85                  90                  95      


Gly Ala Cys Ala Thr Gly Thr Cys Thr Thr Gly Gly Gly Thr Thr Cys 
            100                 105                 110         


Gly Cys Cys Ala Gly Ala Cys Thr Cys Cys Gly Gly Ala Gly Ala Ala 
        115                 120                 125             


Gly Ala Gly Gly Cys Thr Gly Gly Thr Gly Thr Gly Gly Gly Thr Cys 
    130                 135                 140                 


Gly Cys Ala Thr Ala Cys Ala Thr Thr Ala Cys Thr Ala Thr Thr Gly 
145                 150                 155                 160 


Gly Thr Gly Gly Thr Gly Gly Cys Ala Cys Cys Ala Cys Cys Thr Ala 
                165                 170                 175     


Cys Thr Ala Thr Thr Cys Ala Gly Ala Cys Ala Cys Thr Gly Thr Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Cys Gly Ala Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Thr Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Thr Gly Cys 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Cys Cys Cys Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Ala Ala Thr Gly Ala Gly Cys Ala Gly Thr Cys 
                245                 250                 255     


Thr Gly Ala Ala Gly Thr Cys Thr Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Ala Gly Cys Cys Ala Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Gly Ala Cys Ala Thr Ala Gly Gly Thr Ala Cys Gly 
    290                 295                 300                 


Ala Thr Thr Ala Cys Thr Thr Cys Gly Cys Thr Ala Thr Gly Gly Ala 
305                 310                 315                 320 


Cys Ala Ala Cys Thr Gly Gly Gly Gly Thr Cys Ala Thr Gly Gly Ala 
                325                 330                 335     


Ala Cys Cys Thr Cys Ala Gly Thr Cys Ala Cys Cys Gly Thr Cys Thr 
            340                 345                 350         


Cys Cys Thr Cys Ala 
        355         


<210>  26
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagagca cagggccacc       60

atctcctgcc aagccagcga aaatgttgat aattatggca ttaattttat gaactggttc      120

caacacaaac cagcacagcc accccaactc ctcatctatg tttcatccaa cctaggatcc      180

ggggtccctg ccaagtttag tggcagtggg tctggaacag acttcagcct caacatccat      240

cctatggaag aagatgatac tgcaatgtat ttctgtcagc aaagtaagga cgttccgtgg      300

acgttcagtg gaggcaccaa actggaaatc aaacgg                                336


<210>  27
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  28
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
gaagtgaagt tggtggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatacca tgtcttggat tcgccagact      120

ccagagaaga ggctggagtg ggtcgcatac attagtcatg gtggtggtga cacctactat      180

ccagacactg taaagggccg attcaccatc tccagggaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acggccatgt attactgtgc aagacatagt      300

ggttacgaga ggggatatta ctatgttatg gattactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Asp Ile Val Leu Thr Gln Phe Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Phe Ser Phe Ile Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
gacattgtgc tgacccaatt tccaacttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat tactatggct ttagttttat aaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa ccagggatcc      180

ggggtccctg ccaggtttgg tggcagtggg tctgggacag acttcagcct caacatccat      240

cctatggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttccgtgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgg                                336


<210>  31
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210>  32
<211>  1357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
cgaagtgaag ttggtggagt ctgggggagg tttagtgcag cctggagggt ccctgaaact       60

ctcctgtgca gcctctggat tcactttcag tagctatacc atgtcttgga ttcgccagac      120

tccagagaag aggctggagt gggtcgcata cattagtcat ggtggtggtg acacctacta      180

tccagacact gtaaagggcc gattcaccat ctccagggac aatgccaaga acaccctgta      240

cctgcaaatg agcagtctga agtctgagga cacggccatg tattactgtg caagacatag      300

tggttacgag aggggatatt actatgttat ggattactgg ggtcaaggaa cctcagtcac      360

cgtctcctca gctagcacca agggccccag cgtgtttcct ctcgctccct gcagccggag      420

cacatccgag agcaccgctg ctctgggctg tctcgtgaag gactacttcc ctgaacccgt      480

caccgtcagc tggaatagcg gcgccctgac atccggcgtc cacacattcc ccgctgtcct      540

gcagagcagc ggcctgtaca gcctgagctc cgtggtcacc gtgcctagca gcagcctggg      600

aacaaagacc tacacctgca acgtggacca taagccctcc aacaccaagg tggacaagcg      660

ggtggaatcc aagtatggac ccccctgtcc tccttgccct gctcctgaat ttctcggagg      720

cccctccgtc ttcctgtttc cccccaagcc caaggacacc ctgatgatct cccggacacc      780

cgaagtcacc tgcgtcgtgg tggatgtcag ccaggaagat cccgaggtgc agttcaactg      840

gtacgtggac ggagtggagg tgcataacgc caaaaccaag cccagggaag agcagttcaa      900

cagcacctat cgggtcgtgt ccgtgctcac cgtcctgcat caggattggc tcaacggcaa      960

ggagtacaag tgcaaggtgt ccaacaaggg cctgccctcc tccatcgaga agaccatctc     1020

caaggctaag ggccaacctc gggagcccca agtgtatacc ctccctccca gccaggagga     1080

gatgaccaag aatcaagtga gcctgacctg cctcgtgaag ggattttacc cctccgacat     1140

cgctgtggaa tgggaaagca atggccaacc tgagaacaac tacaagacca caccccccgt     1200

gctggactcc gatggctcct tcttcctgta cagcaggctg accgtggaca aatcccggtg     1260

gcaagaggga aacgtgttca gctgctccgt gatgcacgag gctctccaca accactacac     1320

ccagaagagc ctctccctga gcctcggcaa gtagtaa                              1357


<210>  33
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Asp Ile Val Leu Thr Gln Phe Pro Thr Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Phe Ser Phe Ile Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Gly Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Thr Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  34
<211>  661
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
agacattgtg ctgacccaat ttccaacttc tttggctgtg tctctagggc agagggccac       60

catctcctgc agagccagcg aaagtgttga ttactatggc tttagtttta taaactggtt      120

ccaacagaaa ccaggacagc cacccaaact cctcatctat gctgcatcca accagggatc      180

cggggtccct gccaggtttg gtggcagtgg gtctgggaca gacttcagcc tcaacatcca      240

tcctatggag gaggatgata ctgcaatgta tttctgtcag caaagtaagg aggttccgtg      300

gacgttcggt ggaggcacca agctggaaat caagcggacc gtggccgccc ccagcgtgtt      360

catcttccct cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct      420

gaacaacttc tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag      480

cggcaacagc caggagagcg tgaccgagca acaggactcc aaggacagca cctacagcct      540

gaccagcacc ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga      600

ggtgacccac cagggactgt ctagccccgt gaccaagagc ttcaaccggg gcgagtgcta      660

a                                                                      661


<210>  35
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 


<210>  36
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
cgaagtgcag ctggtggaat ctggcggcgg actggtgcag cctggcggat ctctgagact       60

gtcttgtgcc gcctccggct tcaccttctc cagctacacc atgtcctggg tgcgacaggc      120

tcctggcaag ggcctggaat gggtgtccta catctctcac ggcggaggcg acacctacta      180

cgccgactct gtgaagggcc ggttcaccat ctcccgggac aactccaaga acaccctgta      240

cctgcagatg aactccctgc gggccgagga caccgccgtg tactactgtg ctcggcactc      300

tggctacgag cggggctact actacgtgat ggactactgg ggccagggca ccctcgtgac      360

cgtgtcatct gct                                                         373


<210>  37
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr Tyr Tyr Val Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  38
<211>  373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
cgaagtgcag ctggtggaat ctggcggcgg actggtgcag cctggcggat ctctgagact       60

gtcttgtgcc gcctccggct tcaccttctc cagctacacc atgtcctggg tgcgacaggc      120

tcctggcaag ggcctggaat gggtgtccta catctctcac ggcggaggcg acacctacta      180

ccccgactct gtgaagggcc ggttcaccat ctcccgggac aactccaaga acaccctgta      240

cctgcagatg aactccctgc gggccgagga caccgccgtg tactactgtg ctcggcactc      300

tggctacgag cggggctact actacgtgat ggactactgg ggccagggca ccctcgtgac      360

cgtgtcatct gct                                                         373


<210>  39
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser His Gly Gly Gly Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Gly Gly Asp Thr 
65                  70                  75                  80  


Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Ser Gly Tyr Glu Arg Gly Tyr 
        115                 120                 125             


Tyr Tyr Val Met Asp Tyr Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala 
145     


<210>  40
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
gaagtgaagc tgctggaatc tggcggcgga ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttctcc agctacacca tgtcctgggt gcgacaggct      120

cctggcaagg gcctggaatg ggtgtcctac atctctcacg gcggaggcga cacctactac      180

cccgactctg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tcggcactct      300

ggctacgagc ggggctacta ctacgtgatg gactactggg gcaagggcac caccgtgacc      360

gtgtcatctg ct                                                          372


<210>  41
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Phe Ser Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  42
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
agacatcgtg atgacccagt cccccgactc cctggctgtg tctctgggcg agagagccac       60

catcaactgc aagtcctccg agtccgtgga ctactacggc ttctccttcc tgaactggtt      120

ccagcagaag cccggccagc cccctaagct gctgatctac gccgcctcca accgcgagtc      180

tggcgtgccc gatagattct ccggctctgg ctctggcacc gactttaccc tgaccatcag      240

ctccctgcag gccgaggatg tggccgtgta ctactgccag cagtccaaag aggtgccctg      300

gaccttcggc cagggcacaa agctggaaat caagcgg                               337


<210>  43
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Phe Ser Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  44
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
agacatcgtg atgacccagt cccccgactc cctggctgtg tctctgggcg agagagccac       60

catcaactgc aaggcctccg agtccgtgga ctactacggc ttctccttcc tgaactggtt      120

ccagcagaag cccggccagc cccctaagct gctgatctac gccgcctcca accgcgagtc      180

tggcgtgccc gatagattct ccggctctgg ctctggcacc gactttaccc tgaccatcag      240

ctccctgcag gccgaggatg tggccgtgta ctactgccag cagtccaaag aggtgccctg      300

gaccttcggc cagggcacaa agctggaaat caagcgg                               337


<210>  45
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Phe Ser Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Arg Gln Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gln Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Phe Cys Gln Gln 
            100                 105                 110         


Ser Lys Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg 
    130 


<210>  46
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gacatccagc tgacccagtc ccccgactcc ctgtctgtgt ctctgggcga gagagccacc       60

atcaactgca aggcctccga gtccgtggac tactacggct tctccttcct gaactggttc      120

cagcagaagc ccggccagcc ccctaagctg ctgatctacg ccgcctccaa ccgccagtct      180

ggcgtgcccg atagattctc cggctctggc tctggcaccg actttaccct gaccatcagc      240

tccctgcagg ccgaggatgt ggccgtgtac ttctgccagc agtccaaaga ggtgccctgg      300

accttcggcc agggcacaaa gctggaaatc aagcgg                                336


<210>  47
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
ctgtctagaa tgcagatccc acaggcgcc                                         29


<210>  48
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
ggatcctcag aggggccaag agcagt                                            26


