                         SEQUENCE LISTING

<110>  CELDARA MEDICAL, LLC
 
<120>  CHIMERIC ANTIGEN RECEPTORS TARGETING TIM-1

<130>  56867.1001

<150>  62/445,976
<151>  2017-01-13

<160>  316

<170>  PatentIn version 3.5

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<210>  51

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<210>  55

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<210>  56

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<210>  57

<400>  57
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<210>  58

<400>  58
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<210>  59

<400>  59
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<210>  60

<400>  60
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<210>  61

<400>  61
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<210>  62

<400>  62
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<210>  63

<400>  63
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<210>  64

<400>  64
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<210>  65

<400>  65
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<210>  66

<400>  66
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<210>  67

<400>  67
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<210>  68

<400>  68
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<210>  69

<400>  69
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<210>  70

<400>  70
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<210>  71

<400>  71
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<210>  72

<400>  72
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<210>  73

<400>  73
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<210>  74

<400>  74
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<210>  75

<400>  75
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<210>  76

<400>  76
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<210>  77

<400>  77
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<210>  78

<400>  78
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<210>  79

<400>  79
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<210>  80

<400>  80
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<210>  81

<400>  81
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<210>  82

<400>  82
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<210>  83

<400>  83
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<210>  84

<400>  84
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<210>  85

<400>  85
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<210>  86

<400>  86
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<210>  87

<400>  87
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<210>  88

<400>  88
000

<210>  89

<400>  89
000

<210>  90

<400>  90
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<210>  91

<400>  91
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<210>  92

<400>  92
000

<210>  93

<400>  93
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<210>  94

<400>  94
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<210>  95

<400>  95
000

<210>  96

<400>  96
000


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592 minimal binding epitope

<400>  97

Leu Pro Arg Gln Asn His 
1               5       


<210>  98

<400>  98
000

<210>  99

<400>  99
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<210>  100

<400>  100
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<210>  101

<400>  101
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<210>  102

<400>  102
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<210>  103

<400>  103
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<210>  104

<400>  104
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<210>  105

<400>  105
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<210>  106

<400>  106
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<210>  107

<400>  107
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<210>  108

<400>  108
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<210>  109

<400>  109
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<210>  110

<400>  110
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<210>  111

<400>  111
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<210>  112

<400>  112
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<210>  113

<400>  113
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<210>  114

<400>  114
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<210>  115

<400>  115
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<210>  116

<400>  116
000

<210>  117

<400>  117
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<210>  118

<400>  118
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<210>  119

<400>  119
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<210>  120

<400>  120
000

<210>  121

<400>  121
000

<210>  122

<400>  122
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<210>  123

<400>  123
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<210>  124

<400>  124
000

<210>  125

<400>  125
000

<210>  126

<400>  126
000

<210>  127

<400>  127
000

<210>  128

<400>  128
000

<210>  129

<400>  129
000

<210>  130

<400>  130
000

<210>  131

<400>  131
000

<210>  132

<400>  132
000

<210>  133

<400>  133
000

<210>  134

<400>  134
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<210>  135

<400>  135
000

<210>  136

<400>  136
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<210>  137

<400>  137
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<210>  138

<400>  138
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<210>  139

<400>  139
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<210>  140

<400>  140
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<210>  141

<400>  141
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<210>  142

<400>  142
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<210>  143

<400>  143
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<210>  144

<400>  144
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<210>  145

<400>  145
000

<210>  146

<400>  146
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<210>  147

<400>  147
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<210>  148

<400>  148
000

<210>  149

<400>  149
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<210>  150

<400>  150
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<210>  151

<400>  151
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<210>  152

<400>  152
000

<210>  153

<400>  153
000

<210>  154

<400>  154
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<210>  155

<400>  155
000

<210>  156

<400>  156
000

<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163

<400>  163
000

<210>  164

<400>  164
000

<210>  165

<400>  165
000

<210>  166

<400>  166
000

<210>  167

<400>  167
000

<210>  168

<400>  168
000

<210>  169

<400>  169
000

<210>  170

<400>  170
000

<210>  171

<400>  171
000

<210>  172

<400>  172
000

<210>  173

<400>  173
000

<210>  174

<400>  174
000

<210>  175

<400>  175
000

<210>  176

<400>  176
000

<210>  177

<400>  177
000

<210>  178

<400>  178
000

<210>  179

<400>  179
000

<210>  180

<400>  180
000

<210>  181

<400>  181
000

<210>  182

<400>  182
000

<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188

<400>  188
000

<210>  189

<400>  189
000

<210>  190

<400>  190
000

<210>  191

<400>  191
000

<210>  192

<400>  192
000

<210>  193

<400>  193
000

<210>  194

<400>  194
000

<210>  195

<400>  195
000

<210>  196

<400>  196
000

<210>  197

<400>  197
000

<210>  198

<400>  198
000

<210>  199

<400>  199
000


<210>  200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker region subunit

<400>  200

Gly Gly Gly Gly Ser 
1               5   


<210>  201
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker region

<400>  201

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  202
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 VH

<400>  202

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Phe Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Asp Trp Ser Phe His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  203
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 VL

<400>  203

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  204
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 VH

<400>  204

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp Gly Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  205
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 VL

<400>  205

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Val Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  206
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 VH

<400>  206

Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr Ser Gly Phe Asp 
            100                 105                 110         


Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  207
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 VL

<400>  207

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  208
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  129 hv-linker-lv

<400>  208

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Phe Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Tyr Asp Trp Ser Phe His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
    210                 215                 220                 


Gln His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  209
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  129 lv-linker-hv

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr Trp Ser Trp 
145                 150                 155                 160 


Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Phe Ile Tyr 
                165                 170                 175     


Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser 
            180                 185                 190         


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Asp 
    210                 215                 220                 


Trp Ser Phe His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  210
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272 hv-linker-lv

<400>  210

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp Gly Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln 
    130                 135                 140                 


Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr 
                165                 170                 175     


Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
            180                 185                 190         


Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
    210                 215                 220                 


Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val Glu Phe Pro Ile 
225                 230                 235                 240 


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 250     


<210>  211
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272 lv-linker-hv

<400>  211

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Arg Val Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
    130                 135                 140                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Tyr 
145                 150                 155                 160 


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Lys Trp Val 
                165                 170                 175     


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr Ala Asp Ser Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp Gly Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250     


<210>  212
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592 hv-linker-lv

<400>  212

Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp 
            20                  25                  30          


Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr Ser Gly Phe Asp 
            100                 105                 110         


Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu Lys Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln 
            180                 185                 190         


Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr Phe Gly Pro Gly 
225                 230                 235                 240 


Thr Lys Val Asp Ile Lys 
                245     


<210>  213
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592 lv-linker-hv

<400>  213

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Arg Leu Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Gly Ser Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp 
145                 150                 155                 160 


Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr 
                165                 170                 175     


Tyr Ser Gly Ser Thr Phe Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala 
            180                 185                 190         


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
        195                 200                 205             


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro 
    210                 215                 220                 


His Ser Ser Asn Trp Tyr Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  214
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain

<400>  214

Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser 
1               5                   10                  15      


Lys Pro 
        


<210>  215
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  215

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  216
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB costim domain

<400>  216

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  217
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 costim domain

<400>  217

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  218
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAP10 costim domain

<400>  218

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  219
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta intracellular domain

<400>  219

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    50                  55                  60                  


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
65                  70                  75                  80  


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                85                  90                  95      


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            100                 105                 110         


Pro Arg 
        


<210>  220
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  129H-CD28H-CD28TM-CD28CYP-CD3zetaCYP CAR (includes leader)

<400>  220

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Val Ser Ser Gly Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Phe Ile Tyr Tyr Thr Gly Ser Thr Asn 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Ala 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Asp Trp Ser Phe His Phe Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     


Thr Lys Val Glu Ile Lys Ala Ser Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  221
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  129L-CD28H-CD28TM-CD28CYP-CD3zetaCYP CAR (includes leader)

<400>  221

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Arg Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Gly Tyr 
                165                 170                 175     


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Phe Ile Tyr Tyr Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
        195                 200                 205             


Ser Arg Val Ser Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
    210                 215                 220                 


Lys Leu Ser Ser Val Thr Ala Ala Asp Ala Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Asp Tyr Asp Trp Ser Phe His Phe Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ser Ala Ser Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Leu 
            340                 345                 350         


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
        355                 360                 365             


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
    370                 375                 380                 


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
385                 390                 395                 400 


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                405                 410                 415     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            420                 425                 430         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        435                 440                 445             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460                 


Arg 
465 


<210>  222
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272H-CD28H-CD28TM-BBCYP-CD3zetaCYP CAR (includes leader)

<400>  222

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
        35                  40                  45              


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp 
            180                 185                 190         


Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val 
                245                 250                 255     


Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
305                 310                 315                 320 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                325                 330                 335     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            340                 345                 350         


Glu Glu Glu Gly Gly Cys Glu Leu Lys Leu Arg Val Lys Phe Ser Arg 
        355                 360                 365             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
385                 390                 395                 400 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
                405                 410                 415     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475 


<210>  223
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272H-CD28H-CD28TM-CD28CYP-CD3zetaCYP CAR (includes leader)

<400>  223

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
        35                  40                  45              


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp 
            180                 185                 190         


Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val 
                245                 250                 255     


Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
                405                 410                 415     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            420                 425                 430         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        435                 440                 445             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    450                 455                 460                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 


<210>  224
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272H-CD28H-CD28TM-DAP10CYP-CD3zetaCYP CAR (includes leader)

<400>  224

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
        35                  40                  45              


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp 
            180                 185                 190         


Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val 
                245                 250                 255     


Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Leu Cys 
305                 310                 315                 320 


Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile 
                325                 330                 335     


Asn Met Pro Gly Arg Gly Lys Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
385                 390                 395                 400 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                405                 410                 415     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            420                 425                 430         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        435                 440                 445             


Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455         


<210>  225
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  272L-CD28H-CD28TM-CD28CYP-CD3zetaCYP CAR (includes leader)

<400>  225

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg 
65                  70                  75                  80  


Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Arg Val Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
145                 150                 155                 160 


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
                165                 170                 175     


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
            180                 185                 190         


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
        195                 200                 205             


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
                245                 250                 255     


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
                405                 410                 415     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            420                 425                 430         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        435                 440                 445             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    450                 455                 460                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 


<210>  226
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592H-CD28H-CD28TM-BBCYP-CD3zetaCYP CAR (includes leader)

<400>  226

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr 
        115                 120                 125             


Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        355                 360                 365             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    370                 375                 380                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
385                 390                 395                 400 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  227
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592H-CD28H-CD28TM-CD28CYP-CD3zetaCYP CAR (includes leader)

<400>  227

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr 
        115                 120                 125             


Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg 
465                 


<210>  228
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592H-CD28H-CD28TM-DAP10CYP-CD3zetaCYP CAR (includes leader)

<400>  228

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr 
        115                 120                 125             


Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg 
305                 310                 315                 320 


Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg 
                325                 330                 335     


Gly Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg 
    450         


<210>  229
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2592L-CD28H-CD28TM-CD28CYP-CD3ZCYP CAR (includes leader)

<400>  229

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser 
            20                  25                  30          


Val Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Ser Arg Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser 
            100                 105                 110         


Asn Leu Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln Thr Leu 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp Gly Tyr 
                165                 170                 175     


Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe Tyr Asn Pro Ser Leu Lys 
        195                 200                 205             


Ser Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
    210                 215                 220                 


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Glu Ser Pro His Ser Ser Asn Trp Tyr Ser Gly Phe Asp Cys Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg 
465                 


<210>  230
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  230

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  231
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip sequence

<400>  231

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  232
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated CD19

<400>  232

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr 
                325         


<210>  233
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR H1

<400>  233

Gly Gly Ser Val Ser Ser Gly Gly Tyr Tyr 
1               5                   10  


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR H2

<400>  234

Ile Tyr Tyr Thr Gly Ser Thr 
1               5           


<210>  235
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR H3

<400>  235

Asp Tyr Asp Trp Ser Phe His Phe Asp Tyr 
1               5                   10  


<210>  236
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR L1

<400>  236

Gln Gly Ile Arg Asn Asp 
1               5       


<210>  237
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR L2

<400>  237

Ala Ala Ser 
1           


<210>  238
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR L3

<400>  238

Leu Gln His Asn Ser Tyr Pro 
1               5           


<210>  239
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR H1

<400>  239

Gly Phe Ile Phe Ser Arg Tyr Gly 
1               5               


<210>  240
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR H2

<400>  240

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  241
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR H3

<400>  241

Asp Tyr Tyr Asp Asn Ser Arg His His Trp Gly Phe Asp Tyr 
1               5                   10                  


<210>  242
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR L1

<400>  242

Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp Gly Asn Thr Tyr Leu 
1               5                   10                  15      


Asp 
    


<210>  243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR L2

<400>  243

Thr Leu Ser Tyr Arg Ala Ser 
1               5           


<210>  244
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR L3

<400>  244

Met Gln Arg Val Glu Phe Pro Ile Thr 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR H1

<400>  245

Gly Gly Ser Ile Ser Ser Asp Gly Tyr 
1               5                   


<210>  246
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR H2

<400>  246

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  247
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR H3

<400>  247

Glu Ser Pro His Ser Ser Asn Trp Tyr Ser Gly Phe Asp Cys 
1               5                   10                  


<210>  248
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR L1

<400>  248

Gln Ser Ile Gly Ser Arg 
1               5       


<210>  249
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR L2

<400>  249

Tyr Ala Ser 
1           


<210>  250
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR L3

<400>  250

His Gln Ser Ser Asn Leu Pro Phe Thr 
1               5                 


<210>  251
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker region

<400>  251
ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttcc                       45


<210>  252
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 VH

<400>  252
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggag ctggatccgg      120

cagcccccag ggaagggact ggagtggatt gggtttatct attacactgg gagcaccaac      180

tacaacccct ccctcaagag tcgagtctcc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgctgcg gacgcggccg tgtattactg tgcgagagat      300

tatgactgga gcttccactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360


<210>  253
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 VL

<400>  253
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa a                                                321


<210>  254
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 VH

<400>  254
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      300

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      360

gtctcctca                                                              369


<210>  255
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 VL

<400>  255
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtcg gagcctcttg gatagtgatg atggaaacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctacacgct ttcctatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tgtagagttt      300

cctatcacct tcggccaagg gacacgactg gagattaaa                             339


<210>  256
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 VH

<400>  256
caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      180

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      300

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  257
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 VL

<400>  257
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc       60

atcacctgcc gggccagtca gagcattggt agtaggttac actggtacca gcagaaacca      120

gatcagtctc caaagctcct catcaagtat gcttcccagt ccttctcagg ggtcccctcg      180

aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct      240

gaagatgctg caacgtatta ctgtcatcag agtagtaatt taccattcac tttcggccct      300

gggaccaaag tggatatcaa a                                                321


<210>  258
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  129 hv-linker-lv

<400>  258
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggag ctggatccgg      120

cagcccccag ggaagggact ggagtggatt gggtttatct attacactgg gagcaccaac      180

tacaacccct ccctcaagag tcgagtctcc atatcagtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgctgcg gacgcggccg tgtattactg tgcgagagat      300

tatgactgga gcttccactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      360

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctata ggagacagag tcaccatcac ttgccgggca      480

agtcagggca ttagaaatga tttaggctgg tatcagcaga aaccagggaa agcccctaag      540

cgcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagcggcagt      600

ggatctggga cagaattcac tctcacaatc agcagcctgc agcctgaaga ttttgcaact      660

tattactgtc tacagcataa tagttaccct ctcactttcg gcggagggac caaggtggag      720

atcaaa                                                                 726


<210>  259
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  129 lv-linker-hv

<400>  259
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca      120

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa aggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgcagctgca ggagtcgggc ccaggactgg tgaagccttc ggagaccctg      420

tccctcacct gcactgtctc tggtggctcc gtcagcagtg gtggttacta ctggagctgg      480

atccggcagc ccccagggaa gggactggag tggattgggt ttatctatta cactgggagc      540

accaactaca acccctccct caagagtcga gtctccatat cagtagacac gtccaagaac      600

cagttctccc tgaagctgag ctctgtgacc gctgcggacg cggccgtgta ttactgtgcg      660

agagattatg actggagctt ccactttgac tactggggcc agggaaccct ggtcaccgtc      720

tcctca                                                                 726


<210>  260
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272 hv-linker-lv

<400>  260
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      300

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      360

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      420

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      480

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      540

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      600

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      660

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      720

accttcggcc aagggacacg actggagatt aaa                                   753


<210>  261
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272 lv-linker-hv

<400>  261   
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtcg gagcctcttg gatagtgatg atggaaacac ctatttggac      120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctacacgct ttcctatcgg      180

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tgtagagttt      300

cctatcacct tcggccaagg gacacgactg gagattaaag gtggtggtgg ttctggcggc      360

ggcggctccg gtggtggtgg ttcccaggtg cagctggtgg agtctggggg aggcgtggtc      420

cagcctggga ggtccctgag actctcctgt gcagcgtctg gattcatctt cagtcgctat      480

ggcatgcact gggtccgcca ggctccaggc aaggggctga aatgggtggc agttatatgg      540

tatgatggaa gtaataaact ctatgcagac tccgtgaagg gccgattcac catctccaga      600

gacaattcca agaacacgct gtatctgcaa atgaacagcc tgagagccga ggacacggct      660

gtgtattact gtgcgagaga ttactatgat aatagtagac atcactgggg gtttgactac      720

tggggccagg gaaccctggt caccgtctcc tca                                   753


<210>  262
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2592 hv-linker-lv

<400>  262
caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      120

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      180

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      240

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      300

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      360

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      420

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      480

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      540

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      600

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      660

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      720

accaaagtgg atatcaaa                                                    738


<210>  263
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2592 lv-linker-hv

<400>  263
gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc       60

atcacctgcc gggccagtca gagcattggt agtaggttac actggtacca gcagaaacca      120

gatcagtctc caaagctcct catcaagtat gcttcccagt ccttctcagg ggtcccctcg      180

aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct      240

gaagatgctg caacgtatta ctgtcatcag agtagtaatt taccattcac tttcggccct      300

gggaccaaag tggatatcaa aggtggtggt ggttctggcg gcggcggctc cggtggtggt      360

ggttcccagg tgcagctgca ggagtcgggc ccaagactgg tgaagccttc acagaccctg      420

tccctcacct gcactgtctc tggtggctcc atcagtagtg atggttacta ctggagctgg      480

atccgccagc acccagggaa gggcctggag tggattgggt acatctatta cagtgggagc      540

accttctaca acccgtccct caagagtcga gttgccatat cagtggacac gtctaagaac      600

cagttctccc tgaagctgag ctctgtgact gccgcggaca cggccgtgta ttactgtgcg      660

agagaatccc ctcatagcag caactggtac tcgggctttg actgctgggg ccagggaacc      720

ctggtcaccg tctcctca                                                    738


<210>  264
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain

<400>  264
gtgaaaggga aacacctttg tccaagtccc ctatttcccg gaccttctaa gccc             54


<210>  265
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  265
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  266
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB costim domain

<400>  266
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  267
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 costim domain

<400>  267
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  268
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DAP10 costim domain

<400>  268
ctgtgcgcac gcccacgccg cagccccgcc caagaagatg gcaaagtcta catcaacatg       60

ccaggcaggg gc                                                           72


<210>  269
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zeta intracellular domain

<400>  269
cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg      180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      240

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      300

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                         342


<210>  270
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  129H-CD28H-CD28TM-CD28CYP-CD3ZCYP CAR (includes leader)

<400>  270
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc      120

acctgcactg tctctggtgg ctccgtcagc agtggtggtt actactggag ctggatccgg      180

cagcccccag ggaagggact ggagtggatt gggtttatct attacactgg gagcaccaac      240

tacaacccct ccctcaagag tcgagtctcc atatcagtag acacgtccaa gaaccagttc      300

tccctgaagc tgagctctgt gaccgctgcg gacgcggccg tgtattactg tgcgagagat      360

tatgactgga gcttccactt tgactactgg ggccagggaa ccctggtcac cgtctcctca      420

ggtggtggtg gttctggcgg cggcggctcc ggtggtggtg gttccgacat ccagatgacc      480

cagtctccat cctccctgtc tgcatctata ggagacagag tcaccatcac ttgccgggca      540

agtcagggca ttagaaatga tttaggctgg tatcagcaga aaccagggaa agcccctaag      600

cgcctgatct atgctgcatc cagtttgcaa agtggggtcc catcaaggtt cagcggcagt      660

ggatctggga cagaattcac tctcacaatc agcagcctgc agcctgaaga ttttgcaact      720

tattactgtc tacagcataa tagttaccct ctcactttcg gcggagggac caaggtggag      780

atcaaagcta gcgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      840

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1080

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgctaa                                                   1398


<210>  271
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  129L-CD28H-CD28TM-CD28CYP-CD3ZCYP CAR (includes leader)

<400>  271
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctataggaga cagagtcacc      120

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca      180

gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      240

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      300

gaagattttg caacttatta ctgtctacag cataatagtt accctctcac tttcggcgga      360

gggaccaagg tggagatcaa aggtggtggt ggttctggcg gcggcggctc cggtggtggt      420

ggttcccagg tgcagctgca ggagtcgggc ccaggactgg tgaagccttc ggagaccctg      480

tccctcacct gcactgtctc tggtggctcc gtcagcagtg gtggttacta ctggagctgg      540

atccggcagc ccccagggaa gggactggag tggattgggt ttatctatta cactgggagc      600

accaactaca acccctccct caagagtcga gtctccatat cagtagacac gtccaagaac      660

cagttctccc tgaagctgag ctctgtgacc gctgcggacg cggccgtgta ttactgtgcg      720

agagattatg actggagctt ccactttgac tactggggcc agggaaccct ggtcaccgtc      780

tcctcagcta gcgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      840

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc aagcttagag tgaagttcag caggagcgca     1080

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1140

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1200

ccgcagagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1260

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1320

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1380

gccctgcccc ctcgctaa                                                   1398


<210>  272
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272H-CD28H-CD28TM-BBCYP-CD3ZCYP CAR (includes leader)

<400>  272
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      120

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      180

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      360

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      480

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      540

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      600

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      660

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      720

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      780

accttcggcc aagggacacg actggagatt aaactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaaacgg      960

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1020

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1080

aagcttagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1140

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1200

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1260

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1320

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1380

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgc                     1425


<210>  273
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272H-CD28H-CD28TM-CD28CYP-CD3ZCYP CAR (includes leader)

<400>  273
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      120

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      180

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      360

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      480

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      540

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      600

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      660

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      720

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      780

accttcggcc aagggacacg actggagatt aaactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt      960

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1020

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaag     1080

cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1140

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1200

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1260

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1320

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1380

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1422


<210>  274
<211>  1371
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272H-CD28H-CD28TM-DAP10CYP-CD3ZCYP CAR (includes leader)

<400>  274
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      120

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      180

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      360

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      480

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      540

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      600

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      660

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      720

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      780

accttcggcc aagggacacg actggagatt aaactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgctgtgc      960

gcacgcccac gccgcagccc cgcccaagaa gatggcaaag tctacatcaa catgccaggc     1020

aggggcaagc ttagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1080

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1140

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     1200

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1260

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1320

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg c              1371


<210>  275
<211>  1422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  272L-CD28H-CD28TM-CD28CYP-CD3ZCYP CAR (includes leader)

<400>  275
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc      120

atctcctgca ggtctagtcg gagcctcttg gatagtgatg atggaaacac ctatttggac      180

tggtacctgc agaagccagg gcagtctcca cagctcctga tctacacgct ttcctatcgg      240

gcctctggag tcccagacag gttcagtggc agtgggtcag gcactgattt cacactgaaa      300

atcagcaggg tggaggctga ggatgttgga gtttattact gcatgcaacg tgtagagttt      360

cctatcacct tcggccaagg gacacgactg gagattaaag gtggtggtgg ttctggcggc      420

ggcggctccg gtggtggtgg ttcccaggtg cagctggtgg agtctggggg aggcgtggtc      480

cagcctggga ggtccctgag actctcctgt gcagcgtctg gattcatctt cagtcgctat      540

ggcatgcact gggtccgcca ggctccaggc aaggggctga aatgggtggc agttatatgg      600

tatgatggaa gtaataaact ctatgcagac tccgtgaagg gccgattcac catctccaga      660

gacaattcca agaacacgct gtatctgcaa atgaacagcc tgagagccga ggacacggct      720

gtgtattact gtgcgagaga ttactatgat aatagtagac atcactgggg gtttgactac      780

tggggccagg gaaccctggt caccgtctcc tcactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt      960

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1020

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaag     1080

cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1140

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1200

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1260

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1320

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1380

gacacctacg acgcccttca catgcaggcc ctgccccctc gc                        1422


<210>  276
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2592H-CD28H-CD28TM-BBCYP-CD3ZCYP CAR (includes leader)

<400>  276
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc      120

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      240

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      360

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      420

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      480

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      540

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      600

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      660

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      720

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      780

accaaagtgg atatcaaagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtga aacggggcag aaagaaactc      960

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1020

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgaagct tagagtgaag     1080

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1140

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1200

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1260

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1320

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1380

gcccttcaca tgcaggccct gccccctcgc                                      1410


<210>  277
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2592H-CD28H-CD28TM-CD28CYP-CD3zetaCYP CAR (includes leader)

<400>  277
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc      120

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      240

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      360

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      420

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      480

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      540

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      600

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      660

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      720

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      780

accaaagtgg atatcaaagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      960

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1020

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccaagcttag agtgaagttc     1080

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1140

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1200

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1260

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1320

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1380

cttcacatgc aggccctgcc ccctcgc                                         1407


<210>  278
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2592H-CD28H-CD28TM-DAP10CYP-CD3ZCYP CAR (includes leader)

<400>  278
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc      120

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      240

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      360

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      420

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      480

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      540

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      600

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      660

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      720

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      780

accaaagtgg atatcaaagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtgc tgtgcgcacg cccacgccgc      960

agccccgccc aagaagatgg caaagtctac atcaacatgc caggcagggg caagcttaga     1020

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1080

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1140

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat     1200

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1260

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1320

tacgacgccc ttcacatgca ggccctgccc cctcgc                               1356


<210>  279
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2592L-CD28H-CD28TM-CD28CYP-CD3ZCYP CAR (includes leader)

<400>  279
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc      120

atcacctgcc gggccagtca gagcattggt agtaggttac actggtacca gcagaaacca      180

gatcagtctc caaagctcct catcaagtat gcttcccagt ccttctcagg ggtcccctcg      240

aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct      300

gaagatgctg caacgtatta ctgtcatcag agtagtaatt taccattcac tttcggccct      360

gggaccaaag tggatatcaa aggtggtggt ggttctggcg gcggcggctc cggtggtggt      420

ggttcccagg tgcagctgca ggagtcgggc ccaagactgg tgaagccttc acagaccctg      480

tccctcacct gcactgtctc tggtggctcc atcagtagtg atggttacta ctggagctgg      540

atccgccagc acccagggaa gggcctggag tggattgggt acatctatta cagtgggagc      600

accttctaca acccgtccct caagagtcga gttgccatat cagtggacac gtctaagaac      660

cagttctccc tgaagctgag ctctgtgact gccgcggaca cggccgtgta ttactgtgcg      720

agagaatccc ctcatagcag caactggtac tcgggctttg actgctgggg ccagggaacc      780

ctggtcaccg tctcctcagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      960

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1020

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccaagcttag agtgaagttc     1080

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1140

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1200

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1260

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1320

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1380

cttcacatgc aggccctgcc ccctcgc                                         1407


<210>  280
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  280
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60


<210>  281
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip sequence

<400>  281
ggctccggtg agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc       60

cct                                                                     63


<210>  282
<211>  984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated CD19

<400>  282
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac ttaa                                             984


<210>  283
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR H1

<400>  283
ggtggctccg tcagcagtgg tggttactac                                        30


<210>  284
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR H2

<400>  284
atctattaca ctgggagcac c                                                 21


<210>  285
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR H3

<400>  285
gattatgact ggagcttcca ctttgactac                                        30


<210>  286
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR L1

<400>  286
cagggcatta gaaatgat                                                     18


<210>  287
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR L2

<400>  287
gctgcatcc                                                                9


<210>  288
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 129 CDR L3

<400>  288
ctacagcata atagttaccc t                                                 21


<210>  289
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR H1

<400>  289
ggattcatct tcagtcgcta tggc                                              24


<210>  290
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR H2

<400>  290
atatggtatg atggaagtaa taaa                                              24


<210>  291
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR H3

<400>  291
gattactatg ataatagtag acatcactgg gggtttgact ac                          42


<210>  292
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR L1

<400>  292
aggtctagtc ggagcctctt ggatagtgat gatggaaaca cctatttgga c                51


<210>  293
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR L2

<400>  293
acgctttcct atcgggcctc t                                                 21


<210>  294
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 272 CDR L3

<400>  294
atgcaacgtg tagagtttcc tatcacc                                           27


<210>  295
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR H1

<400>  295
ggtggctcca tcagtagtga tggttac                                           27


<210>  296
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR H2

<400>  296
atctattaca gtgggagcac c                                                 21


<210>  297
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR H3

<400>  297
gaatcccctc atagcagcaa ctggtactcg ggctttgact gc                          42


<210>  298
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR L1

<400>  298
cagagcattg gtagtagg                                                     18


<210>  299
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR L2

<400>  299
tatgcttcc                                                                9


<210>  300
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab 2592 CDR L3

<400>  300
catcagagta gtaatttacc attcact                                           27


<210>  301
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_272H-CD28H-CD28TM-BBCYP-CD3ZCYP_T2A-tCD19

<400>  301

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
        35                  40                  45              


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp 
            180                 185                 190         


Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val 
                245                 250                 255     


Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
305                 310                 315                 320 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                325                 330                 335     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            340                 345                 350         


Glu Glu Glu Gly Gly Cys Glu Leu Lys Leu Arg Val Lys Phe Ser Arg 
        355                 360                 365             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    370                 375                 380                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
385                 390                 395                 400 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn 
                405                 410                 415     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            420                 425                 430         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        435                 440                 445             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    450                 455                 460                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Gly Ala Lys Arg 
465                 470                 475                 480 


Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu 
            500                 505                 510         


Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val 
        515                 520                 525             


Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr 
    530                 535                 540                 


Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu 
545                 550                 555                 560 


Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His 
                565                 570                 575     


Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln 
            580                 585                 590         


Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala 
        595                 600                 605             


Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe 
    610                 615                 620                 


Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn 
625                 630                 635                 640 


Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro 
                645                 650                 655     


Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu 
            660                 665                 670         


Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln 
        675                 680                 685             


Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
    690                 695                 700                 


Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His 
705                 710                 715                 720 


Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg 
                725                 730                 735     


Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg 
            740                 745                 750         


Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu 
        755                 760                 765             


Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His 
    770                 775                 780                 


Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala 
785                 790                 795                 800 


Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln 
                805                 810                 815     


Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
            820                 825                 


<210>  302
<211>  2490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_272H-CD28H-CD28TM-BBCYP-CD3ZCYP_T2A-tCD19

<400>  302
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      120

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      180

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      360

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      480

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      540

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      600

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      660

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      720

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      780

accttcggcc aagggacacg actggagatt aaactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaaacgg      960

ggcagaaaga aactcctgta tatattcaaa caaccattta tgagaccagt acaaactact     1020

caagaggaag atggctgtag ctgccgattt ccagaagaag aagaaggagg atgtgaactg     1080

aagcttagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac     1140

cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga     1200

cgtggccggg accctgagat ggggggaaag ccgcagagaa ggaagaaccc tcaggaaggc     1260

ctgtacaatg aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa     1320

ggcgagcgcc ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc     1380

aaggacacct acgacgccct tcacatgcag gccctgcccc ctcgcgccgg cgccaaaagg     1440

tctggctccg gtgagggcag aggaagtctt ctaacatgcg gtgacgtgga ggagaatccc     1500

ggccctatgc cacctcctcg cctcctcttc ttcctcctct tcctcacccc catggaagtc     1560

aggcccgagg aacctctagt ggtgaaggtg gaagagggag ataacgctgt gctgcagtgc     1620

ctcaagggga cctcagatgg ccccactcag cagctgacct ggtctcggga gtccccgctt     1680

aaacccttct taaaactcag cctggggctg ccaggcctgg gaatccacat gaggcccctg     1740

gccatctggc ttttcatctt caacgtctct caacagatgg ggggcttcta cctgtgccag     1800

ccggggcccc cctctgagaa ggcctggcag cctggctgga cagtcaatgt ggagggcagc     1860

ggggagctgt tccggtggaa tgtttcggac ctaggtggcc tgggctgtgg cctgaagaac     1920

aggtcctcag agggccccag ctccccttcc gggaagctca tgagccccaa gctgtatgtg     1980

tgggccaaag accgccctga gatctgggag ggagagcctc cgtgtctccc accgagggac     2040

agcctgaacc agagcctcag ccaggacctc accatggccc ctggctccac actctggctg     2100

tcctgtgggg taccccctga ctctgtgtcc aggggccccc tctcctggac ccatgtgcac     2160

cccaaggggc ctaagtcatt gctgagccta gagctgaagg acgatcgccc ggccagagat     2220

atgtgggtaa tggagacggg tctgttgttg ccccgggcca cagctcaaga cgctggaaag     2280

tattattgtc accgtggcaa cctgaccatg tcattccacc tggagatcac tgctcggcca     2340

gtactatggc actggctgct gaggactggt ggctggaagg tctcagctgt gactttggct     2400

tatctgatct tctgcctgtg ttcccttgtg ggcattcttc atcttcaaag agccctggtc     2460

ctgaggagga aaagaaagcg aatgacttaa                                      2490


<210>  303
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_272H-CD28H-CD28TM-CD28CYP-CD3ZCYP_T2A-tCD19

<400>  303

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
        35                  40                  45              


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp 
            180                 185                 190         


Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val 
                245                 250                 255     


Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
305                 310                 315                 320 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
                325                 330                 335     


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
            340                 345                 350         


Asp Phe Ala Ala Tyr Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro 
                405                 410                 415     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            420                 425                 430         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        435                 440                 445             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    450                 455                 460                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ala Gly Ala Lys Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
                485                 490                 495     


Glu Asn Pro Gly Pro Arg Met Pro Pro Pro Arg Leu Leu Phe Phe Leu 
            500                 505                 510         


Leu Phe Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val 
        515                 520                 525             


Lys Val Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr 
    530                 535                 540                 


Ser Asp Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu 
545                 550                 555                 560 


Lys Pro Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His 
                565                 570                 575     


Met Arg Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln 
            580                 585                 590         


Met Gly Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala 
        595                 600                 605             


Trp Gln Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe 
    610                 615                 620                 


Arg Trp Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn 
625                 630                 635                 640 


Arg Ser Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro 
                645                 650                 655     


Lys Leu Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu 
            660                 665                 670         


Pro Pro Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln 
        675                 680                 685             


Asp Leu Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val 
    690                 695                 700                 


Pro Pro Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His 
705                 710                 715                 720 


Pro Lys Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg 
                725                 730                 735     


Pro Ala Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg 
            740                 745                 750         


Ala Thr Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu 
        755                 760                 765             


Thr Met Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His 
    770                 775                 780                 


Trp Leu Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala 
785                 790                 795                 800 


Tyr Leu Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln 
                805                 810                 815     


Arg Ala Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
            820                 825                 


<210>  304
<211>  2490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_272H-CD28H-CD28TM-CD28CYP-CD3ZCYP_T2A-tCD19

<400>  304
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      120

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      180

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      360

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      480

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      540

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      600

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      660

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      720

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      780

accttcggcc aagggacacg actggagatt aaactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt      960

aagaggagca ggctcctgca cagtgactac atgaacatga ctccccgccg ccccgggccc     1020

acccgcaagc attaccagcc ctatgcccca ccacgcgact tcgcagccta tcgctccaag     1080

cttagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     1140

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt     1200

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg     1260

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc     1320

gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag     1380

gacacctacg acgcccttca catgcaggcc ctgccccctc gcgccggcgc caaaaggtct     1440

ggctccggtg agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc     1500

cctagaatgc cacctcctcg cctcctcttc ttcctcctct tcctcacccc catggaagtc     1560

aggcccgagg aacctctagt ggtgaaggtg gaagagggag ataacgctgt gctgcagtgc     1620

ctcaagggga cctcagatgg ccccactcag cagctgacct ggtctcggga gtccccgctt     1680

aaacccttct taaaactcag cctggggctg ccaggcctgg gaatccacat gaggcccctg     1740

gccatctggc ttttcatctt caacgtctct caacagatgg ggggcttcta cctgtgccag     1800

ccggggcccc cctctgagaa ggcctggcag cctggctgga cagtcaatgt ggagggcagc     1860

ggggagctgt tccggtggaa tgtttcggac ctaggtggcc tgggctgtgg cctgaagaac     1920

aggtcctcag agggccccag ctccccttcc gggaagctca tgagccccaa gctgtatgtg     1980

tgggccaaag accgccctga gatctgggag ggagagcctc cgtgtctccc accgagggac     2040

agcctgaacc agagcctcag ccaggacctc accatggccc ctggctccac actctggctg     2100

tcctgtgggg taccccctga ctctgtgtcc aggggccccc tctcctggac ccatgtgcac     2160

cccaaggggc ctaagtcatt gctgagccta gagctgaagg acgatcgccc ggccagagat     2220

atgtgggtaa tggagacggg tctgttgttg ccccgggcca cagctcaaga cgctggaaag     2280

tattattgtc accgtggcaa cctgaccatg tcattccacc tggagatcac tgctcggcca     2340

gtactatggc actggctgct gaggactggt ggctggaagg tctcagctgt gactttggct     2400

tatctgatct tctgcctgtg ttcccttgtg ggcattcttc atcttcaaag agccctggtc     2460

ctgaggagga aaagaaagcg aatgacttaa                                      2490


<210>  305
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_272H-CD28H-CD28TM-DAP10CYP-CD3ZCYP_T2A-tCD19

<400>  305

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile 
        35                  40                  45              


Phe Ser Arg Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Lys Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Leu Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Tyr Tyr Asp Asn Ser Arg His His Trp 
        115                 120                 125             


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Arg Ser Ser Arg Ser Leu Leu Asp Ser Asp Asp 
            180                 185                 190         


Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        195                 200                 205             


Gln Leu Leu Ile Tyr Thr Leu Ser Tyr Arg Ala Ser Gly Val Pro Asp 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
225                 230                 235                 240 


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Arg Val 
                245                 250                 255     


Glu Phe Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Leu 
            260                 265                 270         


Glu Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro 
        275                 280                 285             


Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
    290                 295                 300                 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Leu Cys 
305                 310                 315                 320 


Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile 
                325                 330                 335     


Asn Met Pro Gly Arg Gly Lys Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
385                 390                 395                 400 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                405                 410                 415     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            420                 425                 430         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        435                 440                 445             


Leu His Met Gln Ala Leu Pro Pro Arg Ala Gly Ala Lys Arg Ser Gly 
    450                 455                 460                 


Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu 
465                 470                 475                 480 


Asn Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe 
                485                 490                 495     


Leu Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val 
            500                 505                 510         


Glu Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp 
        515                 520                 525             


Gly Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro 
    530                 535                 540                 


Phe Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg 
545                 550                 555                 560 


Pro Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly 
                565                 570                 575     


Gly Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln 
            580                 585                 590         


Pro Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp 
        595                 600                 605             


Asn Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser 
    610                 615                 620                 


Ser Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu 
625                 630                 635                 640 


Tyr Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro 
                645                 650                 655     


Cys Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu 
            660                 665                 670         


Thr Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro 
        675                 680                 685             


Asp Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys 
    690                 695                 700                 


Gly Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala 
705                 710                 715                 720 


Arg Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr 
                725                 730                 735     


Ala Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met 
            740                 745                 750         


Ser Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu 
        755                 760                 765             


Leu Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu 
    770                 775                 780                 


Ile Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala 
785                 790                 795                 800 


Leu Val Leu Arg Arg Lys Arg Lys Arg Met Thr 
                805                 810     


<210>  306
<211>  2436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_272H-CD28H-CD28TM-DAP10CYP-CD3ZCYP_T2A-tCD19

<400>  306
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc      120

tcctgtgcag cgtctggatt catcttcagt cgctatggca tgcactgggt ccgccaggct      180

ccaggcaagg ggctgaaatg ggtggcagtt atatggtatg atggaagtaa taaactctat      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagattac      360

tatgataata gtagacatca ctgggggttt gactactggg gccagggaac cctggtcacc      420

gtctcctcag gtggtggtgg ttctggcggc ggcggctccg gtggtggtgg ttccgatatt      480

gtgatgaccc agactccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      540

tgcaggtcta gtcggagcct cttggatagt gatgatggaa acacctattt ggactggtac      600

ctgcagaagc cagggcagtc tccacagctc ctgatctaca cgctttccta tcgggcctct      660

ggagtcccag acaggttcag tggcagtggg tcaggcactg atttcacact gaaaatcagc      720

agggtggagg ctgaggatgt tggagtttat tactgcatgc aacgtgtaga gtttcctatc      780

accttcggcc aagggacacg actggagatt aaactcgagg tgaaagggaa acacctttgt      840

ccaagtcccc tatttcccgg accttctaag cccttttggg tgctggtggt ggttggtgga      900

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgctgtgc      960

gcacgcccac gccgcagccc cgcccaagaa gatggcaaag tctacatcaa catgccaggc     1020

aggggcaagc ttagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1080

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1140

aagagacgtg gccgggaccc tgagatgggg ggaaagccgc agagaaggaa gaaccctcag     1200

gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     1260

atgaaaggcg agcgccggag gggcaagggg cacgatggcc tttaccaggg tctcagtaca     1320

gccaccaagg acacctacga cgcccttcac atgcaggccc tgccccctcg cgccggcgcc     1380

aaaaggtctg gctccggtga gggcagagga agtcttctaa catgcggtga cgtggaggag     1440

aatcccggcc ctatgccacc tcctcgcctc ctcttcttcc tcctcttcct cacccccatg     1500

gaagtcaggc ccgaggaacc tctagtggtg aaggtggaag agggagataa cgctgtgctg     1560

cagtgcctca aggggacctc agatggcccc actcagcagc tgacctggtc tcgggagtcc     1620

ccgcttaaac ccttcttaaa actcagcctg gggctgccag gcctgggaat ccacatgagg     1680

cccctggcca tctggctttt catcttcaac gtctctcaac agatgggggg cttctacctg     1740

tgccagccgg ggcccccctc tgagaaggcc tggcagcctg gctggacagt caatgtggag     1800

ggcagcgggg agctgttccg gtggaatgtt tcggacctag gtggcctggg ctgtggcctg     1860

aagaacaggt cctcagaggg ccccagctcc ccttccggga agctcatgag ccccaagctg     1920

tatgtgtggg ccaaagaccg ccctgagatc tgggagggag agcctccgtg tctcccaccg     1980

agggacagcc tgaaccagag cctcagccag gacctcacca tggcccctgg ctccacactc     2040

tggctgtcct gtggggtacc ccctgactct gtgtccaggg gccccctctc ctggacccat     2100

gtgcacccca aggggcctaa gtcattgctg agcctagagc tgaaggacga tcgcccggcc     2160

agagatatgt gggtaatgga gacgggtctg ttgttgcccc gggccacagc tcaagacgct     2220

ggaaagtatt attgtcaccg tggcaacctg accatgtcat tccacctgga gatcactgct     2280

cggccagtac tatggcactg gctgctgagg actggtggct ggaaggtctc agctgtgact     2340

ttggcttatc tgatcttctg cctgtgttcc cttgtgggca ttcttcatct tcaaagagcc     2400

ctggtcctga ggaggaaaag aaagcgaatg acttaa                               2436


<210>  307
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_2592H-CD28H-CD28TM-BBCYP-CD3ZCYP_T2A-tCD19

<400>  307

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr 
        115                 120                 125             


Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
        355                 360                 365             


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
    370                 375                 380                 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
385                 390                 395                 400 


Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu 
465                 470                 475                 480 


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro 
            500                 505                 510         


Met Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly 
        515                 520                 525             


Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr 
    530                 535                 540                 


Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys 
545                 550                 555                 560 


Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala 
                565                 570                 575     


Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr 
            580                 585                 590         


Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp 
        595                 600                 605             


Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser 
    610                 615                 620                 


Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly 
625                 630                 635                 640 


Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp 
                645                 650                 655     


Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro 
            660                 665                 670         


Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala 
        675                 680                 685             


Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val 
    690                 695                 700                 


Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys 
705                 710                 715                 720 


Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met 
                725                 730                 735     


Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp 
            740                 745                 750         


Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His 
        755                 760                 765             


Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr 
    770                 775                 780                 


Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys 
785                 790                 795                 800 


Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu 
                805                 810                 815     


Arg Arg Lys Arg Lys Arg Met Thr 
            820                 


<210>  308
<211>  2475
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_2592H-CD28H-CD28TM-BBCYP-CD3ZCYP_T2A-tCD19

<400>  308
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc      120

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      240

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      360

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      420

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      480

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      540

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      600

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      660

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      720

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      780

accaaagtgg atatcaaagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtga aacggggcag aaagaaactc      960

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1020

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgaagct tagagtgaag     1080

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag     1140

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1200

gagatggggg gaaagccgca gagaaggaag aaccctcagg aaggcctgta caatgaactg     1260

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1320

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1380

gcccttcaca tgcaggccct gccccctcgc gccggcgcca aaaggtctgg ctccggtgag     1440

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgccacct     1500

cctcgcctcc tcttcttcct cctcttcctc acccccatgg aagtcaggcc cgaggaacct     1560

ctagtggtga aggtggaaga gggagataac gctgtgctgc agtgcctcaa ggggacctca     1620

gatggcccca ctcagcagct gacctggtct cgggagtccc cgcttaaacc cttcttaaaa     1680

ctcagcctgg ggctgccagg cctgggaatc cacatgaggc ccctggccat ctggcttttc     1740

atcttcaacg tctctcaaca gatggggggc ttctacctgt gccagccggg gcccccctct     1800

gagaaggcct ggcagcctgg ctggacagtc aatgtggagg gcagcgggga gctgttccgg     1860

tggaatgttt cggacctagg tggcctgggc tgtggcctga agaacaggtc ctcagagggc     1920

cccagctccc cttccgggaa gctcatgagc cccaagctgt atgtgtgggc caaagaccgc     1980

cctgagatct gggagggaga gcctccgtgt ctcccaccga gggacagcct gaaccagagc     2040

ctcagccagg acctcaccat ggcccctggc tccacactct ggctgtcctg tggggtaccc     2100

cctgactctg tgtccagggg ccccctctcc tggacccatg tgcaccccaa ggggcctaag     2160

tcattgctga gcctagagct gaaggacgat cgcccggcca gagatatgtg ggtaatggag     2220

acgggtctgt tgttgccccg ggccacagct caagacgctg gaaagtatta ttgtcaccgt     2280

ggcaacctga ccatgtcatt ccacctggag atcactgctc ggccagtact atggcactgg     2340

ctgctgagga ctggtggctg gaaggtctca gctgtgactt tggcttatct gatcttctgc     2400

ctgtgttccc ttgtgggcat tcttcatctt caaagagccc tggtcctgag gaggaaaaga     2460

aagcgaatga cttaa                                                      2475


<210>  309
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_2592H-CD28H-CD28TM-CD28CYP-CD3ZCYP_T2A-tCD19

<400>  309

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr 
        115                 120                 125             


Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu Gly 
465                 470                 475                 480 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
            500                 505                 510         


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
        515                 520                 525             


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
    530                 535                 540                 


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
545                 550                 555                 560 


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
                565                 570                 575     


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
            580                 585                 590         


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
        595                 600                 605             


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
    610                 615                 620                 


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
625                 630                 635                 640 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
                645                 650                 655     


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
            660                 665                 670         


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
        675                 680                 685             


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
    690                 695                 700                 


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
705                 710                 715                 720 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
                725                 730                 735     


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
            740                 745                 750         


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
        755                 760                 765             


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
    770                 775                 780                 


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
785                 790                 795                 800 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
                805                 810                 815     


Arg Lys Arg Lys Arg Met Thr 
            820             


<210>  310
<211>  2472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_2592H-CD28H-CD28TM-CD28CYP-CD3ZCYP_T2A-tCD19

<400>  310
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc      120

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      240

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      360

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      420

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      480

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      540

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      600

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      660

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      720

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      780

accaaagtgg atatcaaagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      960

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1020

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccaagcttag agtgaagttc     1080

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1140

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1200

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1260

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1320

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1380

cttcacatgc aggccctgcc ccctcgcgcc ggcgccaaaa ggtctggctc cggtgagggc     1440

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1500

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1560

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1620

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1680

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1740

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1800

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1860

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1920

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1980

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     2040

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2100

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2160

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     2220

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2280

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2340

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2400

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2460

cgaatgactt aa                                                         2472


<210>  311
<211>  806
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_2592H-CD28H-CD28TM-DAP10CYP-CD3ZCYP_T2A-tCD19

<400>  311

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Arg Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser 
        35                  40                  45              


Ile Ser Ser Asp Gly Tyr Tyr Trp Ser Trp Ile Arg Gln His Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe 
65                  70                  75                  80  


Tyr Asn Pro Ser Leu Lys Ser Arg Val Ala Ile Ser Val Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Pro His Ser Ser Asn Trp Tyr 
        115                 120                 125             


Ser Gly Phe Asp Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu 
                165                 170                 175     


Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Arg Leu 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys 
        195                 200                 205             


Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Asn Leu Pro Phe Thr 
                245                 250                 255     


Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Leu Cys Ala Arg Pro Arg Arg 
305                 310                 315                 320 


Ser Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg 
                325                 330                 335     


Gly Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            340                 345                 350         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        355                 360                 365             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    370                 375                 380                 


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg 
    450                 455                 460                 


Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
465                 470                 475                 480 


Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met Glu 
                485                 490                 495     


Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn 
            500                 505                 510         


Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln 
        515                 520                 525             


Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser 
    530                 535                 540                 


Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp 
545                 550                 555                 560 


Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys 
                565                 570                 575     


Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val 
            580                 585                 590         


Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu 
        595                 600                 605             


Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser 
    610                 615                 620                 


Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys 
625                 630                 635                 640 


Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg 
                645                 650                 655     


Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly 
            660                 665                 670         


Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg 
        675                 680                 685             


Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu 
    690                 695                 700                 


Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val 
705                 710                 715                 720 


Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly 
                725                 730                 735     


Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu 
            740                 745                 750         


Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly 
        755                 760                 765             


Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu Cys 
    770                 775                 780                 


Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg Arg 
785                 790                 795                 800 


Lys Arg Lys Arg Met Thr 
                805     


<210>  312
<211>  2421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_2592H-CD28H-CD28TM-DAP10CYP-CD3ZCYP_T2A-tCD19

<400>  312
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

caggtgcagc tgcaggagtc gggcccaaga ctggtgaagc cttcacagac cctgtccctc      120

acctgcactg tctctggtgg ctccatcagt agtgatggtt actactggag ctggatccgc      180

cagcacccag ggaagggcct ggagtggatt gggtacatct attacagtgg gagcaccttc      240

tacaacccgt ccctcaagag tcgagttgcc atatcagtgg acacgtctaa gaaccagttc      300

tccctgaagc tgagctctgt gactgccgcg gacacggccg tgtattactg tgcgagagaa      360

tcccctcata gcagcaactg gtactcgggc tttgactgct ggggccaggg aaccctggtc      420

accgtctcct caggtggtgg tggttctggc ggcggcggct ccggtggtgg tggttccgaa      480

attgtgctga ctcagtctcc agactttcag tctgtgactc caaaggagaa agtcaccatc      540

acctgccggg ccagtcagag cattggtagt aggttacact ggtaccagca gaaaccagat      600

cagtctccaa agctcctcat caagtatgct tcccagtcct tctcaggggt cccctcgagg      660

ttcagtggca gtggatctgg gacagatttc accctcacca tcaatagcct ggaagctgaa      720

gatgctgcaa cgtattactg tcatcagagt agtaatttac cattcacttt cggccctggg      780

accaaagtgg atatcaaagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtgc tgtgcgcacg cccacgccgc      960

agccccgccc aagaagatgg caaagtctac atcaacatgc caggcagggg caagcttaga     1020

gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat     1080

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1140

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat     1200

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc     1260

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc     1320

tacgacgccc ttcacatgca ggccctgccc cctcgcgccg gcgccaaaag gtctggctcc     1380

ggtgagggca gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg     1440

ccacctcctc gcctcctctt cttcctcctc ttcctcaccc ccatggaagt caggcccgag     1500

gaacctctag tggtgaaggt ggaagaggga gataacgctg tgctgcagtg cctcaagggg     1560

acctcagatg gccccactca gcagctgacc tggtctcggg agtccccgct taaacccttc     1620

ttaaaactca gcctggggct gccaggcctg ggaatccaca tgaggcccct ggccatctgg     1680

cttttcatct tcaacgtctc tcaacagatg gggggcttct acctgtgcca gccggggccc     1740

ccctctgaga aggcctggca gcctggctgg acagtcaatg tggagggcag cggggagctg     1800

ttccggtgga atgtttcgga cctaggtggc ctgggctgtg gcctgaagaa caggtcctca     1860

gagggcccca gctccccttc cgggaagctc atgagcccca agctgtatgt gtgggccaaa     1920

gaccgccctg agatctggga gggagagcct ccgtgtctcc caccgaggga cagcctgaac     1980

cagagcctca gccaggacct caccatggcc cctggctcca cactctggct gtcctgtggg     2040

gtaccccctg actctgtgtc caggggcccc ctctcctgga cccatgtgca ccccaagggg     2100

cctaagtcat tgctgagcct agagctgaag gacgatcgcc cggccagaga tatgtgggta     2160

atggagacgg gtctgttgtt gccccgggcc acagctcaag acgctggaaa gtattattgt     2220

caccgtggca acctgaccat gtcattccac ctggagatca ctgctcggcc agtactatgg     2280

cactggctgc tgaggactgg tggctggaag gtctcagctg tgactttggc ttatctgatc     2340

ttctgcctgt gttcccttgt gggcattctt catcttcaaa gagccctggt cctgaggagg     2400

aaaagaaagc gaatgactta a                                               2421


<210>  313
<211>  823
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader_2592L-CD28H-CD28TM-CD28CYP-CD3ZCYP_T2A-tCD19

<400>  313

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser 
            20                  25                  30          


Val Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Ser Arg Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser Phe Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
                85                  90                  95      


Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser 
            100                 105                 110         


Asn Leu Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Gln Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Gln Thr Leu 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Asp Gly Tyr 
                165                 170                 175     


Tyr Trp Ser Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Phe Tyr Asn Pro Ser Leu Lys 
        195                 200                 205             


Ser Arg Val Ala Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
    210                 215                 220                 


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Glu Ser Pro His Ser Ser Asn Trp Tyr Ser Gly Phe Asp Cys Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Val Lys Gly Lys 
            260                 265                 270         


His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp 
        275                 280                 285             


Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val 
    290                 295                 300                 


Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu 
305                 310                 315                 320 


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
                325                 330                 335     


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
            340                 345                 350         


Arg Ser Lys Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
                405                 410                 415     


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
            420                 425                 430         


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
        435                 440                 445             


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
    450                 455                 460                 


Ala Leu Pro Pro Arg Ala Gly Ala Lys Arg Ser Gly Ser Gly Glu Gly 
465                 470                 475                 480 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
            500                 505                 510         


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
        515                 520                 525             


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
    530                 535                 540                 


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
545                 550                 555                 560 


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
                565                 570                 575     


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
            580                 585                 590         


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
        595                 600                 605             


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
    610                 615                 620                 


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
625                 630                 635                 640 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
                645                 650                 655     


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
            660                 665                 670         


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
        675                 680                 685             


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
    690                 695                 700                 


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
705                 710                 715                 720 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
                725                 730                 735     


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
            740                 745                 750         


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
        755                 760                 765             


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
    770                 775                 780                 


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
785                 790                 795                 800 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
                805                 810                 815     


Arg Lys Arg Lys Arg Met Thr 
            820             


<210>  314
<211>  2472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader_2592L-CD28H-CD28TM-CD28CYP-CD3ZCYP_T2A-tCD19

<400>  314
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgc tgactcagtc tccagacttt cagtctgtga ctccaaagga gaaagtcacc      120

atcacctgcc gggccagtca gagcattggt agtaggttac actggtacca gcagaaacca      180

gatcagtctc caaagctcct catcaagtat gcttcccagt ccttctcagg ggtcccctcg      240

aggttcagtg gcagtggatc tgggacagat ttcaccctca ccatcaatag cctggaagct      300

gaagatgctg caacgtatta ctgtcatcag agtagtaatt taccattcac tttcggccct      360

gggaccaaag tggatatcaa aggtggtggt ggttctggcg gcggcggctc cggtggtggt      420

ggttcccagg tgcagctgca ggagtcgggc ccaagactgg tgaagccttc acagaccctg      480

tccctcacct gcactgtctc tggtggctcc atcagtagtg atggttacta ctggagctgg      540

atccgccagc acccagggaa gggcctggag tggattgggt acatctatta cagtgggagc      600

accttctaca acccgtccct caagagtcga gttgccatat cagtggacac gtctaagaac      660

cagttctccc tgaagctgag ctctgtgact gccgcggaca cggccgtgta ttactgtgcg      720

agagaatccc ctcatagcag caactggtac tcgggctttg actgctgggg ccagggaacc      780

ctggtcaccg tctcctcagc tagcgtgaaa gggaaacacc tttgtccaag tcccctattt      840

cccggacctt ctaagccctt ttgggtgctg gtggtggttg gtggagtcct ggcttgctat      900

agcttgctag taacagtggc ctttattatt ttctgggtga ggagtaagag gagcaggctc      960

ctgcacagtg actacatgaa catgactccc cgccgccccg ggcccacccg caagcattac     1020

cagccctatg ccccaccacg cgacttcgca gcctatcgct ccaagcttag agtgaagttc     1080

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1140

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1200

atggggggaa agccgcagag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1260

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1320

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1380

cttcacatgc aggccctgcc ccctcgcgcc ggcgccaaaa ggtctggctc cggtgagggc     1440

agaggaagtc ttctaacatg cggtgacgtg gaggagaatc ccggccctat gccacctcct     1500

cgcctcctct tcttcctcct cttcctcacc cccatggaag tcaggcccga ggaacctcta     1560

gtggtgaagg tggaagaggg agataacgct gtgctgcagt gcctcaaggg gacctcagat     1620

ggccccactc agcagctgac ctggtctcgg gagtccccgc ttaaaccctt cttaaaactc     1680

agcctggggc tgccaggcct gggaatccac atgaggcccc tggccatctg gcttttcatc     1740

ttcaacgtct ctcaacagat ggggggcttc tacctgtgcc agccggggcc cccctctgag     1800

aaggcctggc agcctggctg gacagtcaat gtggagggca gcggggagct gttccggtgg     1860

aatgtttcgg acctaggtgg cctgggctgt ggcctgaaga acaggtcctc agagggcccc     1920

agctcccctt ccgggaagct catgagcccc aagctgtatg tgtgggccaa agaccgccct     1980

gagatctggg agggagagcc tccgtgtctc ccaccgaggg acagcctgaa ccagagcctc     2040

agccaggacc tcaccatggc ccctggctcc acactctggc tgtcctgtgg ggtaccccct     2100

gactctgtgt ccaggggccc cctctcctgg acccatgtgc accccaaggg gcctaagtca     2160

ttgctgagcc tagagctgaa ggacgatcgc ccggccagag atatgtgggt aatggagacg     2220

ggtctgttgt tgccccgggc cacagctcaa gacgctggaa agtattattg tcaccgtggc     2280

aacctgacca tgtcattcca cctggagatc actgctcggc cagtactatg gcactggctg     2340

ctgaggactg gtggctggaa ggtctcagct gtgactttgg cttatctgat cttctgcctg     2400

tgttcccttg tgggcattct tcatcttcaa agagccctgg tcctgaggag gaaaagaaag     2460

cgaatgactt aa                                                         2472


<210>  315
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  315

Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Thr Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr Thr Val Pro Thr Thr 
                165                 170                 175     


Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr Thr Thr Ser Ile Pro 
            180                 185                 190         


Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val Ser Thr Phe Val Pro 
        195                 200                 205             


Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro Val Ala Thr Ser Pro 
    210                 215                 220                 


Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr Thr Leu Gln Gly Ala 
225                 230                 235                 240 


Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr Ser Tyr Thr Thr Asp 
                245                 250                 255     


Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly Leu Trp Asn Asn Asn 
            260                 265                 270         


Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu Thr Ala Asn Thr Thr 
        275                 280                 285             


Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala 
    290                 295                 300                 


Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe Phe Lys Lys Glu Val 
305                 310                 315                 320 


Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln Ile Lys Ala Leu Gln 
                325                 330                 335     


Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp Asn Ile Tyr Ile Glu 
            340                 345                 350         


Asn Ser Leu Tyr Ala Thr Asp 
        355                 


<210>  316
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker region subunit

<400>  316
ggtggtggtg gttct                                                        15

