
                                SEQUENCE LISTING

<110> EUREKA THERAPEUTICS, INC.

<120> CONSTRUCTS TARGETING HISTONE H3
  PEPTIDE/MHC COMPLEXES AND USES THEREOF
  

<130> 750042000940

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> US 62/445,665       
<151> 2017-01-12  

<150> US 62/572,300       
<151> 2017-10-13  

<160> 167

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone H3.3

<400> 1
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro
 1               5                  10                  15      
Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser Thr
            20                  25                  30          
Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu
        35                  40                  45              
Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys
    50                  55                  60                  
Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Thr
65                  70                  75                  80  
Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala Ser
                85                  90                  95      
Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile
            100                 105                 110         
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg
        115                 120                 125             
Arg Ile Arg Gly Glu Arg Ala
    130                 135 


<210> 2
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone H3.1

<400> 2
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro
 1               5                  10                  15      
Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala Thr
            20                  25                  30          
Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu
        35                  40                  45              
Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys
    50                  55                  60                  
Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Thr
65                  70                  75                  80  
Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala Cys
                85                  90                  95      
Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile
            100                 105                 110         
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg
        115                 120                 125             
Arg Ile Arg Gly Glu Arg Ala
    130                 135 


<210> 3
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone K27M-H3.3

<400> 3
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro
 1               5                  10                  15      
Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Met Ser Ala Pro Ser Thr
            20                  25                  30          
Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu
        35                  40                  45              
Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys
    50                  55                  60                  
Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Thr
65                  70                  75                  80  
Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala Ser
                85                  90                  95      
Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile
            100                 105                 110         
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg
        115                 120                 125             
Arg Ile Arg Gly Glu Arg Ala
    130                 135 


<210> 4
<211> 135
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone K27M-H3.1

<400> 4
Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Pro
 1               5                  10                  15      
Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Met Ser Ala Pro Ala Thr
            20                  25                  30          
Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala Leu
        35                  40                  45              
Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg Lys
    50                  55                  60                  
Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Thr
65                  70                  75                  80  
Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala Cys
                85                  90                  95      
Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala Ile
            100                 105                 110         
His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala Arg
        115                 120                 125             
Arg Ile Arg Gly Glu Arg Ala
    130                 135 


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone H3.3 26-35

<400> 5
Arg Lys Ser Ala Pro Ser Thr Gly Gly Val
 1               5                  10  


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone H3.1 26-35

<400> 6
Arg Lys Ser Ala Pro Ala Thr Gly Gly Val
 1               5                  10  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone H3.3 26-35 K27M

<400> 7
Arg Met Ser Ala Pro Ser Thr Gly Gly Val
 1               5                  10  


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Histone H3.1 26-35 K27M

<400> 8
Arg Met Ser Ala Pro Ala Thr Gly Gly Val
 1               5                  10  


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A1

<400> 9
Ala Met Ser Ala Pro Ser Thr Gly Gly Val
 1               5                  10  


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A2

<400> 10
Arg Ala Ser Ala Pro Ser Thr Gly Gly Val
 1               5                  10  


<210> 11
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A3

<400> 11
Arg Met Ala Ala Pro Ser Thr Gly Gly Val
 1               5                  10  


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A5

<400> 12
Arg Met Ser Ala Ala Ser Thr Gly Gly Val
 1               5                  10  


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A7

<400> 13
Arg Met Ser Ala Pro Ser Ala Gly Gly Val
 1               5                  10  


<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A8

<400> 14
Arg Met Ser Ala Pro Ser Thr Ala Gly Val
 1               5                  10  


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A9

<400> 15
Arg Met Ser Ala Pro Ser Thr Gly Ala Val
 1               5                  10  


<210> 16
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.3 A10

<400> 16
Arg Met Ser Ala Pro Ser Thr Gly Gly Ala
 1               5                  10  


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A1

<400> 17
Ala Met Ser Ala Pro Ala Thr Gly Gly Val
 1               5                  10  


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A2

<400> 18
Arg Ala Ser Ala Pro Ala Thr Gly Gly Val
 1               5                  10  


<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A3

<400> 19
Arg Met Ala Ala Pro Ala Thr Gly Gly Val
 1               5                  10  


<210> 20
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A5

<400> 20
Arg Met Ser Ala Ala Ala Thr Gly Gly Val
 1               5                  10  


<210> 21
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A7

<400> 21
Arg Met Ser Ala Pro Ala Ala Gly Gly Val
 1               5                  10  


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A8

<400> 22
Arg Met Ser Ala Pro Ala Thr Ala Gly Val
 1               5                  10  


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A9

<400> 23
Arg Met Ser Ala Pro Ala Thr Gly Ala Val
 1               5                  10  


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> K27M-H3.1 A10

<400> 24
Arg Met Ser Ala Pro Ala Thr Gly Gly Ala
 1               5                  10  


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> C3 control peptide (A2E-7)

<400> 25
Tyr Leu Leu Pro Ala Ile Val His Ile
 1               5                  


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-1

<400> 26
Leu Leu Asp Val Pro Thr Ala Ala Val
 1               5                  


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-2

<400> 27
Thr Leu Trp Val Asp Pro Tyr Glu Val
 1               5                  


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-3

<400> 28
Phe Leu Leu Asp His Leu Lys Arg Val
 1               5                  


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-4

<400> 29
Leu Leu Leu Asp Val Pro Thr Ala Ala Val
 1               5                  10  


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-5

<400> 30
Val Leu Phe Arg Gly Gly Pro Arg Gly Leu Leu Ala Val
 1               5                  10              


<210> 31
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-6

<400> 31
Ser Leu Leu Pro Ala Ile Val Glu Leu
 1               5                  


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-8

<400> 32
Phe Leu Leu Pro Thr Gly Ala Glu Ala
 1               5                  


<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-9

<400> 33
Leu Leu Asp Pro Lys Leu Cys Tyr Leu Leu
 1               5                  10  


<210> 34
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-11

<400> 34
Met Leu Leu Ser Val Pro Leu Leu Leu Gly
 1               5                  10  


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> A2E-17

<400> 35
Met Val Asp Gly Thr Leu Leu Leu Leu
 1               5                  


<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> DMTN  control

<400> 36
Ser Leu Pro His Phe His His Pro Glu Thr
 1               5                  10  


<210> 37
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> PIM1  control

<400> 37
Leu Leu Tyr Asp Met Val Cys Gly Asp Ile Pro
 1               5                  10      


<210> 38
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> IFI30  control

<400> 38
Leu Leu Leu Asp Val Pro Thr Ala Ala Val Gln
 1               5                  10      


<210> 39
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> IFI30  control

<400> 39
Leu Leu Leu Asp Val Pro Thr Ala Ala Val Gln Ala
 1               5                  10          


<210> 40
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> SSR1  control

<400> 40
Val Leu Phe Arg Gly Gly Pro Arg Gly Leu Leu Ala Val Ala
 1               5                  10                  


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> RPS6KB1  control

<400> 41
Tyr Met Ala Pro Glu Ile Leu Met Arg Ser
 1               5                  10  


<210> 42
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> CSF2RA  control

<400> 42
Phe Ile Tyr Asn Ala Asp Leu Met Asn Cys
 1               5                  10  


<210> 43
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> IL7 control

<400> 43
Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile
 1               5                  10      


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Beta globin control

<400> 44
Lys Val Asn Val Asp Glu Val Gly Gly Glu
 1               5                  10  


<210> 45
<211> 247
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-HMC scFv 5

<400> 45
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
                85                  90                  95      
Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu
    130                 135                 140                 
Val Lys Lys Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly
145                 150                 155                 160 
Tyr Ser Phe Thr Ser Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly
                165                 170                 175     
Lys Gly Leu Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr
            180                 185                 190         
Arg Tyr Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys
        195                 200                 205             
Ser Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp
    210                 215                 220                 
Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Asp Gly Trp Gly Gln Gly
225                 230                 235                 240 
Thr Leu Val Thr Val Ser Ser
                245         


<210> 46
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv linker

<400> 46
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
 1               5                  10                  15      
Ser Leu Glu Met Ala
            20      


<210> 47
<211> 243
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-CD3 scFv

<400> 47
Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr
            20                  25                  30          
Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr Gly Ser Gly
        115                 120                 125             
Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu Thr Gln Ser
    130                 135                 140                 
Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys
145                 150                 155                 160 
Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro
                165                 170                 175     
Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser
            180                 185                 190         
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser
        195                 200                 205             
Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys
    210                 215                 220                 
Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly Thr Lys Val
225                 230                 235                 240 
Glu Ile Lys
            


<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> BiTE linker

<400> 48
Thr Ser Gly Gly Gly Gly Ser
 1               5          


<210> 49
<211> 222
<212> PRT
<213> Artificial Sequence

<220> 
<223> CD28/CD3zeta

<400> 49
Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu
 1               5                  10                  15      
Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro
            20                  25                  30          
Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val
        35                  40                  45              
Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe
    50                  55                  60                  
Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp
65                  70                  75                  80  
Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr
                85                  90                  95      
Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val
            100                 105                 110         
Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn
        115                 120                 125             
Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val
    130                 135                 140                 
Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg
145                 150                 155                 160 
Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys
                165                 170                 175     
Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg
            180                 185                 190         
Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys
        195                 200                 205             
Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
    210                 215                 220         


<210> 50
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> 4-1BB/CD3zeta

<400> 50
Thr Gly Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr
 1               5                  10                  15      
Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala
            20                  25                  30          
Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile
        35                  40                  45              
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser
    50                  55                  60                  
Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr
65                  70                  75                  80  
Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu
                85                  90                  95      
Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu
            100                 105                 110         
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
        115                 120                 125             
Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
    130                 135                 140                 
Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
145                 150                 155                 160 
Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln
                165                 170                 175     
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
            180                 185                 190         
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
        195                 200                 205             
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
    210                 215                 220                 
Arg
225 


<210> 51
<211> 142
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha constant domain

<400> 51
Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser
 1               5                  10                  15      
Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln
            20                  25                  30          
Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys
        35                  40                  45              
Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val
    50                  55                  60                  
Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn
65                  70                  75                  80  
Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys
                85                  90                  95      
Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn
            100                 105                 110         
Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val
        115                 120                 125             
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    130                 135                 140         


<210> 52
<211> 177
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta constant domain

<400> 52
Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro
 1               5                  10                  15      
Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu
            20                  25                  30          
Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn
        35                  40                  45              
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys
    50                  55                  60                  
Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu
65                  70                  75                  80  
Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys
                85                  90                  95      
Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp
            100                 105                 110         
Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg
        115                 120                 125             
Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser
    130                 135                 140                 
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala
145                 150                 155                 160 
Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp
                165                 170                 175     
Phe
    


<210> 53
<211> 153
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRdelta constant domain

<400> 53
Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr
 1               5                  10                  15      
Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile
            20                  25                  30          
Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val
        35                  40                  45              
Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu
    50                  55                  60                  
Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val
65                  70                  75                  80  
His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys
                85                  90                  95      
Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys
            100                 105                 110         
Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr
        115                 120                 125             
Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe
    130                 135                 140                 
Leu Leu Thr Ala Lys Leu Phe Phe Leu
145                 150             


<210> 54
<211> 173
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRgamma constant domain

<400> 54
Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu
 1               5                  10                  15      
Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys
            20                  25                  30          
Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu
        35                  40                  45              
Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys
    50                  55                  60                  
Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys
65                  70                  75                  80  
Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys
                85                  90                  95      
Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val
            100                 105                 110         
Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr
        115                 120                 125             
Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu
    130                 135                 140                 
Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu
145                 150                 155                 160 
Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser
                165                 170             


<210> 55
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha transmembrane domain

<400> 55
Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg
 1               5                  10                  15      
Leu Trp Ser Ser
            20  


<210> 56
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta transmembrane domain

<400> 56
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val
 1               5                  10                  15      
Leu Val Ser Ala Leu Val Leu
            20              


<210> 57
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRdelta transmembrane domain

<400> 57
Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys
 1               5                  10                  15      
Leu Phe Phe Leu
            20  


<210> 58
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRgamma transmembrane domain

<400> 58
Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala
 1               5                  10                  15      
Ile Ile Thr Cys Cys Leu Leu
            20              


<210> 59
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha connecting peptide

<400> 59
Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp
 1               5                  10                  15      
Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg
            20                  25                  30  


<210> 60
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta connecting peptide

<400> 60
Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser
 1               5                  10                  15      
Ala
    


<210> 61
<211> 41
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRdelta connecting peptide

<400> 61
Asp His Val Lys Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys
 1               5                  10                  15      
Ser Cys His Lys Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met
            20                  25                  30          
Met Ser Leu Thr Val Leu Gly Leu Arg
        35                  40      


<210> 62
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRgamma connecting peptide

<400> 62
Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr Leu Leu
 1               5                  10                  15      
Leu Gln Leu Thr Asn Thr Ser Ala
            20                  


<210> 63
<211> 40
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRalpha connecting peptide MD

<400> 63
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
 1               5                  10                  15      
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            20                  25                  30          
Asn Leu Ser Val Ile Gly Phe Arg
        35                  40  


<210> 64
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta connecting peptide MD

<400> 64
Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val
 1               5                  10                  15      
Leu Ser Ala
            


<210> 65
<211> 48
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRdelta connecting peptide MD

<400> 65
Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu
 1               5                  10                  15      
Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val
            20                  25                  30          
His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg
        35                  40                  45              


<210> 66
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRgamma connecting peptide MD

<400> 66
Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser
 1               5                  10                  15      
Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala
            20                  25                  30          


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRbeta intracellular domain

<400> 67
Met Ala Met Val Lys Arg Lys Asp Phe
 1               5                  


<210> 68
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCRgamma intracellular domain

<400> 68
Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser
 1               5                  10          


<210> 69
<211> 68
<212> PRT
<213> Artificial Sequence

<220> 
<223> T cell receptor domain delta

<400> 69
Glu Val Lys Thr Asp Ser Thr Asp His Val Lys Pro Lys Glu Thr Glu
 1               5                  10                  15      
Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys Pro Lys Ala Ile Val
            20                  25                  30          
His Thr Glu Lys Val Asn Met Met Ser Leu Thr Val Leu Gly Leu Arg
        35                  40                  45              
Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe Leu Leu Thr Ala Lys
    50                  55                  60                  
Leu Phe Phe Leu
65              


<210> 70
<211> 67
<212> PRT
<213> Artificial Sequence

<220> 
<223> T cell receptor domain gamma

<400> 70
Pro Ile Lys Thr Asp Val Ile Thr Met Asp Pro Lys Asp Asn Cys Ser
 1               5                  10                  15      
Lys Asp Ala Asn Asp Thr Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala
            20                  25                  30          
Tyr Tyr Met Tyr Leu Leu Leu Leu Leu Lys Ser Val Val Tyr Phe Ala
        35                  40                  45              
Ile Ile Thr Cys Cys Leu Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly
    50                  55                  60                  
Glu Lys Ser
65          


<210> 71
<211> 60
<212> PRT
<213> Artificial Sequence

<220> 
<223> T cell receptor domain alpha

<400> 71
Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val
 1               5                  10                  15      
Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln
            20                  25                  30          
Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly
        35                  40                  45              
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser
    50                  55                  60  


<210> 72
<211> 51
<212> PRT
<213> Artificial Sequence

<220> 
<223> T cell receptor domain beta

<400> 72
Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val
 1               5                  10                  15      
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu
            20                  25                  30          
Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg
        35                  40                  45              
Lys Asp Phe
    50      


<210> 73
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Signal peptide

<400> 73
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
 1               5                  10                  15      
Gly Ser Thr Gly
            20  


<210> 74
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> fragment of CD28

<400> 74
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
 1               5                  10                  15      
Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30          
Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly
        35                  40                  45              
Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe
    50                  55                  60                  
Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn
65                  70                  75                  80  
Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr
                85                  90                  95      
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser
            100                 105         


<210> 75
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 5

<400> 75
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Asp Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 76
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 10

<400> 76
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 77
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 13

<400> 77
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 78
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 16

<400> 78
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 79
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 31

<400> 79
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asp Arg Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Ala Gly Lys Gly Leu Glu Arg Phe
        35                  40                  45              
Ser Ala Ile Thr Gly Asp Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Gly Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Leu Ser Gly Ile Gly Arg Ser Ser Tyr Asp Gly Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 80
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 32

<400> 80
Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Thr Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Pro Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Asn Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Trp Glu His Gly Phe Pro Tyr Asp Glu Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 81
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 33

<400> 81
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Ala Gly Thr Phe Asn Arg Tyr
            20                  25                  30          
Ser Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Ile Gly Val Ala Asp Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Thr Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu His Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gln Glu Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 82
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 34

<400> 82
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Tyr Trp Thr Phe Glu Tyr Ser Ile Asp Ser Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 83
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 35

<400> 83
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Tyr Glu Ser Gly Tyr Pro Phe Asp Trp Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 84
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 36

<400> 84
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45              
Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ser Trp Trp Ser Pro Val Thr Tyr Tyr Asp Ile Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 85
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 37

<400> 85
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Met Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Val Thr Ser Tyr
            20                  25                  30          
Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val
        35                  40                  45              
Gly Trp Ile Ser Ala Tyr Asn Gly Asp Thr Ile Tyr Ala Gln Lys Leu
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Ser Leu Pro Phe Gly Val Val Pro Asn Ala Phe Asp Ile
            100                 105                 110         
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120             


<210> 86
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> HCVR 38

<400> 86
Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Thr Thr Gly Ala
 1               5                  10                  15      
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Asp Tyr Ser Gly Ser Gly Ser Ser Asp Ala Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 87
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 5

<400> 87
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
                85                  90                  95      
Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 88
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 10

<400> 88
Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Ser Trp Phe His Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Lys Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Phe Tyr Cys Met Gln Gly
                85                  90                  95      
Thr Tyr Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 89
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 13

<400> 89
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Thr Trp Phe His Gln Arg Pro Gly Gln Pro
        35                  40                  45              
Pro Arg Arg Leu Ile His Lys Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
                85                  90                  95      
Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 90
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 16

<400> 90
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Ile Tyr Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Thr Trp Phe His Gln Arg Pro Gly Gln Pro
        35                  40                  45              
Pro Arg Arg Leu Ile His Lys Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln Gly
                85                  90                  95      
Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         
Arg
    


<210> 91
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 31

<400> 91
Gln Ala Val Leu Thr Gln Pro Ser Ser Leu Ser Ala Ser Pro Gly Ala
 1               5                  10                  15      
Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Gly Thr
            20                  25                  30          
Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr
        35                  40                  45              
Leu Leu Arg Tyr Lys Ser Asp Ser Asp Lys Gln Gln Gly Ser Gly Val
    50                  55                  60                  
Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile
65                  70                  75                  80  
Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys
                85                  90                  95      
Met Ile Trp His Ser Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu
            100                 105                 110         
Thr Val Leu Gly
        115     


<210> 92
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 32

<400> 92
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Leu Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val
        35                  40                  45              
Leu Val Tyr Phe Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95      
Leu Ser Ala Ser Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110         


<210> 93
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 33

<400> 93
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Phe Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Ser
                85                  90                  95      
Leu Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 94
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 34

<400> 94
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Leu Asn Leu Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Phe Ala Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110         


<210> 95
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 35

<400> 95
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Phe Asn Ile Gly Ser Asn
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Ala Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Ala Ala Ala Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110         


<210> 96
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 36

<400> 96
Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln
 1               5                  10                  15      
Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
        35                  40                  45              
Ala Lys Ser Asn Arg Pro Ser Gly Ile Ala Asp Arg Phe Ser Gly Ser
    50                  55                  60                  
Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Arg
                85                  90                  95      
Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 


<210> 97
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 37

<400> 97
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110     


<210> 98
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> LCVR 38

<400> 98
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
 1               5                  10                  15      
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
            20                  25                  30          
Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr
        35                  40                  45              
Tyr Asp Asn Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                  
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65                  70                  75                  80  
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asn Ser Ser Ser Asp His
                85                  90                  95      
Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 


<210> 99
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 5

<400> 99
Gly Tyr Ser Phe Thr Ser Tyr Trp
 1               5              


<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 31

<400> 100
Gly Leu Thr Phe Asp Arg Tyr Ala
 1               5              


<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 32

<400> 101
Gly Tyr Thr Phe Thr Ser Tyr Thr
 1               5              


<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 33

<400> 102
Ala Gly Thr Phe Asn Arg Tyr Ser
 1               5              


<210> 103
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 34

<400> 103
Gly Gly Thr Phe Ser Ser Tyr Ala
 1               5              


<210> 104
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 35

<400> 104
Gly Tyr Thr Phe Thr Ser Tyr Gly
 1               5              


<210> 105
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 36

<400> 105
Gly Tyr Thr Phe Thr Gly Tyr Tyr
 1               5              


<210> 106
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 37

<400> 106
Gly Tyr Thr Val Thr Ser Tyr Gly
 1               5              


<210> 107
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 1 38

<400> 107
Gly Tyr Thr Phe Thr Asp Tyr Tyr
 1               5              


<210> 108
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 5

<400> 108
Ile Tyr Pro Gly Asp Ser Asp Thr
 1               5              


<210> 109
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 31

<400> 109
Ile Thr Gly Asp Gly Tyr Tyr Thr
 1               5              


<210> 110
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 32

<400> 110
Ile Ser Pro Tyr Asn Gly Asn Thr
 1               5              


<210> 111
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 33

<400> 111
Ile Ile Pro Ile Ile Gly Val Ala
 1               5              


<210> 112
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 34

<400> 112
Ile Ile Pro Ile Phe Gly Thr Ala
 1               5              


<210> 113
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 35

<400> 113
Ile Ser Ala Tyr Asn Gly Asn Thr
 1               5              


<210> 114
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 36

<400> 114
Phe Asp Pro Glu Asp Gly Glu Thr
 1               5              


<210> 115
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 37

<400> 115
Ile Ser Ala Tyr Asn Gly Asp Thr
 1               5              


<210> 116
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 1 38

<400> 116
Ile Asn Pro His Ser Gly Gly Thr
 1               5              


<210> 117
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 5

<400> 117
Ala Arg Gly Tyr Asp Gly
 1               5      


<210> 118
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 10

<400> 118
Ala Arg Gly Phe Asp Asn
 1               5      


<210> 119
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 13

<400> 119
Ala Arg Gly Tyr Asp Val
 1               5      


<210> 120
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 16

<400> 120
Ala Arg Gly Tyr Asp Ser
 1               5      


<210> 121
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 31

<400> 121
Ala Arg Leu Ser Gly Ile Gly Arg Ser Ser Tyr Asp Gly
 1               5                  10              


<210> 122
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 32

<400> 122
Ala Arg Ser Trp Glu His Gly Phe Pro Tyr Asp Glu
 1               5                  10          


<210> 123
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 33

<400> 123
Ala Arg Gln Glu Tyr Ser Tyr Ala Met Asp Tyr
 1               5                  10      


<210> 124
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 34

<400> 124
Ala Arg Ser Tyr Trp Thr Phe Glu Tyr Ser Ile Asp Ser
 1               5                  10              


<210> 125
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 35

<400> 125
Ala Arg Tyr Tyr Glu Ser Gly Tyr Pro Phe Asp Trp
 1               5                  10          


<210> 126
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 36

<400> 126
Ala Arg Ser Ser Trp Trp Ser Pro Val Thr Tyr Tyr Asp Ile
 1               5                  10                  


<210> 127
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 37

<400> 127
Ala Arg Ser Ser Leu Pro Phe Gly Val Val Pro Asn Ala Phe Asp Ile
 1               5                  10                  15      


<210> 128
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 1 38

<400> 128
Ala Arg Glu Asp Tyr Ser Gly Ser Gly Ser Ser Asp Ala
 1               5                  10              


<210> 129
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 5

<400> 129
Gln Ser Leu Val Tyr Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 130
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 13

<400> 130
Gln Ser Leu Ile Tyr Ser Asn Gly Asn Thr Tyr
 1               5                  10      


<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 31

<400> 131
Ser Gly Ile Asn Val Gly Thr Tyr Arg
 1               5                  


<210> 132
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 32

<400> 132
Ser Ser Asn Leu Gly Ala Gly Tyr Asp
 1               5                  


<210> 133
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 33

<400> 133
Ser Ser Asn Ile Gly Ala Gly Tyr Asp
 1               5                  


<210> 134
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 34

<400> 134
Ser Leu Asn Leu Gly Ala Gly Tyr Asp
 1               5                  


<210> 135
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 35

<400> 135
Thr Phe Asn Ile Gly Ser Asn Thr
 1               5              


<210> 136
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 36

<400> 136
Ser Leu Arg Ser Tyr Tyr
 1               5      


<210> 137
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 37

<400> 137
Ser Ser Asn Ile Gly Ser Asn Thr
 1               5              


<210> 138
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 1 38

<400> 138
Asn Ile Gly Ser Lys Ser
 1               5      


<210> 139
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 5

<400> 139
Glu Val Ser
 1          


<210> 140
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 10

<400> 140
Lys Val Ser
 1          


<210> 141
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 31

<400> 141
Tyr Lys Ser Asp Ser Asp Lys
 1               5          


<210> 142
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 32

<400> 142
Phe Asn Asn
 1          


<210> 143
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 33

<400> 143
Gly Asn Asn
 1          


<210> 144
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 34

<400> 144
Ala Asn Thr
 1          


<210> 145
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 35

<400> 145
Ser Asn Asn
 1          


<210> 146
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 36

<400> 146
Ala Lys Ser
 1          


<210> 147
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR2 1 38

<400> 147
Tyr Asp Asn
 1          


<210> 148
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 5

<400> 148
Met Gln Gly Thr His Trp Pro Pro Thr
 1               5                  


<210> 149
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 10

<400> 149
Met Gln Gly Thr Tyr Trp Pro Tyr Thr
 1               5                  


<210> 150
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 31

<400> 150
Met Ile Trp His Ser Ser Ala
 1               5          


<210> 151
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 32

<400> 151
Gln Ser Tyr Asp Ser Ser Leu Ser Ala Ser Val
 1               5                  10      


<210> 152
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 33

<400> 152
Gln Ser Tyr Asp Thr Ser Leu Thr Pro Val
 1               5                  10  


<210> 153
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 34

<400> 153
Gln Ser Tyr Asp Asn Ser Leu Ser Gly Tyr Val
 1               5                  10      


<210> 154
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 35

<400> 154
Ala Ala Trp Asp Asp Ser Leu Ser Gly His Val Val
 1               5                  10          


<210> 155
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 36

<400> 155
Asn Ser Arg Asp Ser Ser Gly Asn Arg
 1               5                  


<210> 156
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 37

<400> 156
Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val
 1               5                  10      


<210> 157
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 1 38

<400> 157
Gln Val Trp Asn Ser Ser Ser Asp His Tyr Val
 1               5                  10      


<210> 158
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR1 consensus

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Ala or Gly

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Gly or Tyr

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Any Amino Acid

<400> 158
Xaa Xaa Xaa Phe Xaa Xaa Tyr
 1               5          


<210> 159
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR2 consensus

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Ala or Pro

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Ala or Thr

<400> 159
Ile Xaa Xaa Xaa Xaa Gly Xaa Xaa
 1               5              


<210> 160
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 consensus 1

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Phe or Tyr

<400> 160
Ala Arg Gly Xaa Asp
 1               5  


<210> 161
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> HC-CDR3 consensus 2

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Trp or Tyr

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Phe or Tyr

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Phe or Tyr

<400> 161
Ala Arg Xaa Xaa Glu Xaa Gly Xaa Pro Xaa Asp
 1               5                  10      


<210> 162
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR1 consensus

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Any Amino Acid

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Leu, or Asn

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ala, Ser, or Thr

<400> 162
Xaa Xaa Asn Xaa Gly Xaa
 1               5      


<210> 163
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> LC-CDR3 consensus

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Ala or Gln

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Ala or Ser

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Trp or Tyr

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Any Amino Acid

<400> 163
Xaa Xaa Xaa Asp Xaa Ser Leu
 1               5          


<210> 164
<211> 502
<212> PRT
<213> Artificial Sequence

<220> 
<223> BsAb #32

<400> 164
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Leu Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Val
        35                  40                  45              
Leu Val Tyr Phe Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95      
Leu Ser Ala Ser Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110         
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Leu Glu Met Ala Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val
    130                 135                 140                 
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
145                 150                 155                 160 
Thr Phe Thr Ser Tyr Thr Ile Thr Trp Val Arg Gln Ala Pro Gly Gln
                165                 170                 175     
Gly Leu Glu Trp Met Gly Trp Ile Ser Pro Tyr Asn Gly Asn Thr Asn
            180                 185                 190         
Tyr Ala Gln Asn Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser
        195                 200                 205             
Thr Thr Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Arg Ser Trp Glu His Gly Phe Pro Tyr Asp
225                 230                 235                 240 
Glu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Gly
                245                 250                 255     
Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            260                 265                 270         
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        275                 280                 285             
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    290                 295                 300                 
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala
305                 310                 315                 320 
Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser
                325                 330                 335     
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr
            340                 345                 350         
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
        355                 360                 365             
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr
    370                 375                 380                 
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu
385                 390                 395                 400 
Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr
                405                 410                 415     
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln
            420                 425                 430         
Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys
        435                 440                 445             
Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
    450                 455                 460                 
Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr
465                 470                 475                 480 
Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly
                485                 490                 495     
Thr Lys Val Glu Ile Lys
            500         


<210> 165
<211> 503
<212> PRT
<213> Artificial Sequence

<220> 
<223> BsAb #34

<400> 165
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Leu Asn Leu Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Phe Ala Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110         
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Leu Glu Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val
    130                 135                 140                 
Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly
145                 150                 155                 160 
Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln
                165                 170                 175     
Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn
            180                 185                 190         
Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser
        195                 200                 205             
Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Arg Ser Tyr Trp Thr Phe Glu Tyr Ser Ile
225                 230                 235                 240 
Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly
                245                 250                 255     
Gly Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys
            260                 265                 270         
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr
        275                 280                 285             
Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly
    290                 295                 300                 
Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr
305                 310                 315                 320 
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr
                325                 330                 335     
Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala
            340                 345                 350         
Thr Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr
        355                 360                 365             
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser
    370                 375                 380                 
Thr Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val
385                 390                 395                 400 
Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala
                405                 410                 415     
Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr
            420                 425                 430         
Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser
        435                 440                 445             
Lys Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly
    450                 455                 460                 
Thr Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala
465                 470                 475                 480 
Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly
                485                 490                 495     
Gly Thr Lys Val Glu Ile Lys
            500             


<210> 166
<211> 502
<212> PRT
<213> Artificial Sequence

<220> 
<223> BsAb #35

<400> 166
Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Phe Asn Ile Gly Ser Asn
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Ala Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
65                  70                  75                  80  
Ser Glu Asp Ala Ala Ala Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110         
Ser Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        115                 120                 125             
Ser Leu Glu Met Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val
    130                 135                 140                 
Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr
145                 150                 155                 160 
Thr Phe Thr Ser Tyr Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln
                165                 170                 175     
Gly Leu Glu Trp Met Gly Trp Ile Ser Ala Tyr Asn Gly Asn Thr Asn
            180                 185                 190         
Tyr Ala Gln Lys Leu Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser
        195                 200                 205             
Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr
    210                 215                 220                 
Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Glu Ser Gly Tyr Pro Phe Asp
225                 230                 235                 240 
Trp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Thr Ser Gly Gly
                245                 250                 255     
Gly Gly Ser Asp Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            260                 265                 270         
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        275                 280                 285             
Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    290                 295                 300                 
Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Ala
305                 310                 315                 320 
Asp Ser Val Lys Gly Arg Phe Thr Ile Thr Thr Asp Lys Ser Thr Ser
                325                 330                 335     
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr
            340                 345                 350         
Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp
        355                 360                 365             
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Glu Gly Thr Ser Thr
    370                 375                 380                 
Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ala Asp Asp Ile Val Leu
385                 390                 395                 400 
Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr
                405                 410                 415     
Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Tyr Met Asn Trp Tyr Gln
            420                 425                 430         
Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys
        435                 440                 445             
Val Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr
    450                 455                 460                 
Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr
465                 470                 475                 480 
Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gly Gly
                485                 490                 495     
Thr Lys Val Glu Ile Lys
            500         


<210> 167
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Control HIV peptide

<400> 167
Tyr Gln Tyr Met Asp Asp Leu Tyr Val
 1               5                  

