                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Weissman, Drew
       Pardi, Norbert
       Hogan, Michael
 
<120>  Nucleoside-modified RNA for Inducing an Immune Response Against 
       Zika Virus

<130>  046483-6154-00-WO.607149

<150>  US 62/444,931
<151>  2017-01-11

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  2094
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  1
atggccataa gtggagtccc ggtgctagga ttcttcatca tagccgtgct gatgagcgcg       60

caggaatcat gggccgccga ggtgacgaga cgggggagcg catactacat gtacttggac      120

agaaacgacg ccggggaggc catatccttc ccaaccacat tggggatgaa caagtgttac      180

atacagatca tggacctggg acacatgtgc gacgccacca tgagctacga atgccctatg      240

ctggacgagg gggtggaacc agacgacgtc gactgctggt gcaacacgac gtcaacttgg      300

gtggtgtacg gaacctgcca ccacaaaaaa ggcgaagcac ggagatcgag acgggccgtg      360

acgctcccct cccactccac gaggaagctg caaacgcggt cgcaaacctg gttggaatca      420

agagaataca caaagcactt gatcagagtc gaaaactgga tattcaggaa ccctggcttc      480

gcgttagcag cagccgccat cgcttggctg ttgggaagct caacgagcca aaaagtcata      540

tacttggtca tgatactgct gatcgccccg gcatacagca tcaggtgcat aggagtcagc      600

aacagggact tcgtggaagg gatgtcaggc gggacctggg tggacgtggt cttggaacac      660

ggagggtgcg tcaccgtaat ggcacaggac aaaccgacgg tcgacataga gctggttaca      720

acaacagtca gcaacatggc ggaggtaaga tcctactgct acgaggcatc aatatcggac      780

atggcgtcgg acagccgctg cccaacacaa ggcgaagcct acctggacaa gcaatcagac      840

acgcaatacg tctgcaaaag aacgttagtg gacagaggct ggggaaacgg atgcggactg      900

ttcggcaaag ggagcctggt gacatgcgcc aagttcgcat gctccaagaa aatgaccggg      960

aagagcatcc agccagagaa cctggagtac cggataatgc tgtcagtgca cggctcccag     1020

cacagcggga tgatcgtgaa cgacacagga cacgaaacgg acgagaacag agcgaaggtg     1080

gagataacgc ccaactcacc aagagccgaa gccaccctgg ggggcttcgg aagcctagga     1140

ctggactgcg aaccgaggac aggcctcgac ttctcagact tgtactactt gacgatgaac     1200

aacaagcact ggttggtgca caaggagtgg ttccacgaca tcccattacc ttggcacgcc     1260

ggggcagaca ccggaacgcc acactggaac aacaaagaag cactggtaga gttcaaggac     1320

gcacacgcca aaaggcaaac ggtcgtggtc ctagggagcc aagaaggagc agtgcacacg     1380

gccctggccg gagcgctgga ggccgagatg gacggggcaa agggaaggct gtcctccggc     1440

cacttgaaat gccgcctgaa aatggacaaa ctgagattga agggcgtgtc atactccttg     1500

tgcaccgcag cgttcacatt caccaagatc ccggcggaaa cactgcacgg gacagtcaca     1560

gtggaggtac agtacgcagg gacagacgga ccgtgcaagg tgccagcgca gatggcggtg     1620

gacatgcaaa ccctgacccc agtcgggagg ttgataaccg cgaaccccgt aatcacggaa     1680

agcaccgaga actcgaagat gatgctggaa ctcgatccac cattcgggga ctcgtacatc     1740

gtcataggag tcggggagaa gaagatcacc caccactggc acaggagcgg cagcaccatc     1800

ggaaaagcat tcgaagccac ggtgagaggg gccaagagaa tggcagtctt gggagacaca     1860

gcctgggact tcggatcagt cggaggcgcg ctcaactcat tgggcaaggg catccaccaa     1920

atcttcggag cagctttcaa atcattgttc ggaggaatgt cctggttctc acaaatcctc     1980

atcggaacgt tgctgatgtg gttggggctg aacacaaaga acggatcgat ctccctgatg     2040

tgcttggcct tagggggagt gttgatcttc ttatccacag cggtctccgc gtaa           2094


<210>  2
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  2

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ala Glu Val Thr Arg Arg Gly 
            20                  25                  30          


Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile 
        35                  40                  45              


Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile Met 
    50                  55                  60                  


Asp Leu Gly His Met Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met 
65                  70                  75                  80  


Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr 
                85                  90                  95      


Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His His Lys Lys Gly Glu 
            100                 105                 110         


Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg 
        115                 120                 125             


Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr 
    130                 135                 140                 


Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe 
145                 150                 155                 160 


Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser 
                165                 170                 175     


Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr 
            180                 185                 190         


Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met 
        195                 200                 205             


Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu His Gly Gly Cys Val 
    210                 215                 220                 


Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr 
225                 230                 235                 240 


Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala 
                245                 250                 255     


Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu 
            260                 265                 270         


Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr 
        275                 280                 285             


Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly 
    290                 295                 300                 


Ser Leu Val Thr Cys Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly 
305                 310                 315                 320 


Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val 
                325                 330                 335     


His Gly Ser Gln His Ser Gly Met Ile Val Asn Asp Thr Gly His Glu 
            340                 345                 350         


Thr Asp Glu Asn Arg Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg 
        355                 360                 365             


Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu 
    370                 375                 380                 


Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn 
385                 390                 395                 400 


Asn Lys His Trp Leu Val His Lys Glu Trp Phe His Asp Ile Pro Leu 
                405                 410                 415     


Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys 
            420                 425                 430         


Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val 
        435                 440                 445             


Val Val Leu Gly Ser Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly 
    450                 455                 460                 


Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly 
465                 470                 475                 480 


His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val 
                485                 490                 495     


Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala 
            500                 505                 510         


Glu Thr Leu His Gly Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr 
        515                 520                 525             


Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala Val Asp Met Gln Thr 
    530                 535                 540                 


Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu 
545                 550                 555                 560 


Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly 
                565                 570                 575     


Asp Ser Tyr Ile Val Ile Gly Val Gly Glu Lys Lys Ile Thr His His 
            580                 585                 590         


Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val 
        595                 600                 605             


Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe 
    610                 615                 620                 


Gly Ser Val Gly Gly Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln 
625                 630                 635                 640 


Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe 
                645                 650                 655     


Ser Gln Ile Leu Ile Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr 
            660                 665                 670         


Lys Asn Gly Ser Ile Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu 
        675                 680                 685             


Ile Phe Leu Ser Thr Ala Val Ser Ala 
    690                 695         


<210>  3
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  3
ggaaaaaaga ggctatggaa ataataaag                                         29


<210>  4
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  4
ctccttccta gcattgatta ttctca                                            26


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  5
agttcaagaa agatctggct g                                                 21


