                               SEQUENCE LISTING

<110> INTREXON CORPORATION
 
<120> MODULATING EXPRESSION OF POLYPEPTIDES VIA NEW GENE SWITCH 
      EXPRESSION SYSTEMS

<130> 50471-706.601

<140>
<141>

<150> 62/464,958
<151> 2017-02-28

<150> 62/444,775
<151> 2017-01-10

<160> 244   

<170> PatentIn version 3.5

<210> 1
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Whitlow Linker"

<400> 1
ggcagcacct ccggcagcgg caagcctggc agcggcgagg gcagcaccaa gggc             54


<210> 2
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Linker"

<400> 2
tctggcggag gatctggagg aggcggatct ggaggaggag gcagtggagg cggaggatct       60

ggcggaggat ctctgcag                                                     78


<210> 3
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="GSG linker"

<400> 3
ggaagcgga                                                                9


<210> 4
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="SGSG linker"

<400> 4
agtggcagcg gc                                                           12


<210> 5
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="(G4S)3 linker"

<400> 5
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210> 6
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Furin cleavage site/ Furinlink1"

<400> 6
cgtgcaaagc gt                                                           12


<210> 7
<211> 84
<212> DNA
<213> Foot-and-mouth disease virus

<220>
<221> source
<223> /note="Fmdv"

<400> 7
agagccaaga gggcaccggt gaaacagact ttgaattttg accttctgaa gttggcagga       60

gacgttgagt ccaaccctgg gccc                                              84


<210> 8
<211> 54
<212> DNA
<213> Thosea asigna virus

<220>
<221> source
<223> /note="Thosea asigna virus 2A region (T2A)"

<400> 8
gagggcagag gaagtctgct aacatgcggt gacgtcgagg agaatcctgg acct             54


<210> 9
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Furin-GSG-T2A"

<400> 9
agagctaaga ggggaagcgg agagggcaga ggaagtctgc taacatgcgg tgacgtcgag       60

gagaatcctg gacct                                                        75


<210> 10
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Furin-SGSG-T2A"

<400> 10
agggccaaga ggagtggcag cggcgagggc agaggaagtc ttctaacatg cggtgacgtg       60

gaggagaatc ccggccct                                                     78


<210> 11
<211> 57
<212> DNA
<213> Porcine teschovirus

<220>
<221> source
<223> /note="Porcine teschovirus-1 2A region (P2A)"

<400> 11
gcaacgaact tctctctcct aaaacaggct ggtgatgtgg aggagaatcc tggtcca          57


<210> 12
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="GSG-P2A"

<400> 12
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210> 13
<211> 60
<212> DNA
<213> Equine rhinitis A virus

<220>
<221> source
<223> /note="Equine rhinitis A virus 2A region (E2A)"

<400> 13
cagtgtacta attatgctct cttgaaattg gctggagatg ttgagagcaa ccctggacct       60


<210> 14
<211> 66
<212> DNA
<213> Foot-and-mouth disease virus

<220>
<221> source
<223> /note="Foot-and-mouth disease virus 2A region (F2A)"

<400> 14
gtcaaacaga ccctaaactt tgatctgcta aaactggccg gggatgtgga aagtaatccc       60

ggcccc                                                                  66


<210> 15
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="FP2A"

<400> 15
cgtgcaaagc gtgcaccggt gaaacaggga agcggagcta ctaacttcag cctgctgaag       60

caggctggag acgtggagga gaaccctgga cct                                    93


<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Linker-GSG"

<400> 16
gcaccggtga aacagggaag cgga                                              24


<210> 17
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Linker"

<400> 17
gcaccggtga aacag                                                        15


<210> 18
<211> 570
<212> DNA
<213> Encephalomyocarditis virus

<220>
<221> source
<223> /note="EMCV IRES"

<400> 18
ccccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

gcacatgctt tacatgtgtt tagtcgaggt taaaaaacgt ctaggccccc cgaaccacgg      540

ggacgtggtt ttcctttgaa aaacacgatc                                       570


<210> 19
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="2xRbm3 IRES"

<400> 19
actagtttta taatttcttc ttccagaatt tctgacattt tataatttct tcttccagaa       60

gactcacaac ctc                                                          73


<210> 20
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="GM-CSFR-alpha  signal peptide"

<400> 20
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atccca                                                                  66


<210> 21
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="GM-CSFR-alpha  signal peptide"

<400> 21
atgctgctgc tggtgaccag cctgctgctg tgtgagctgc cccaccccgc ctttctgctg       60

atcccc                                                                  66


<210> 22
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Ig Kappa signal peptide"

<400> 22
atgaggctcc ctgctcagct cctggggctg ctaatgctct gggtcccagg atccagtggg       60


<210> 23
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="IgE signal peptide"

<400> 23
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagc             54


<210> 24
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="CD8-alpha signal peptide"

<400> 24
atggcgctgc ccgtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210> 25
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="CD8-alpha signal peptide"

<400> 25
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210> 26
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="TVB2(T21A)signal peptide"

<400> 26
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat       60

gct                                                                     63


<210> 27
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="CD52 signal peptide"

<400> 27
atgaagcgct tcctcttcct cctactcacc atcagcctcc tggttatggt acagatacaa       60

actggactct ca                                                           72


<210> 28
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Low-affinity nerve growth factor receptor 
      (LNGFR, TNFRSF16) signal peptide"

<400> 28
atgggggcag gtgccaccgg ccgcgccatg gacgggccgc gcctgctgct gttgctgctt       60

ctgggggtgt cccttggagg tgcc                                              84


<210> 29
<211> 141
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD8-alpha hinge region"

<400> 29
aagcccacca ccacccctgc ccctagacct ccaaccccag cccctacaat cgccagccag       60

cccctgagcc tgaggcccga agcctgtaga cctgccgctg gcggagccgt gcacaccaga      120

ggcctggatt tcgcctgcga c                                                141


<210> 30
<211> 282
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD8 alpha 2x"

<400> 30
aaacctacta caactcctgc cccccggcct cctacaccag ctcctactat cgcctcccag       60

ccactcagtc tcagacccga ggcttctagg ccagcggccg gaggcgcggt ccacacccgc      120

gggctggact ttgcatccga taagcccacc accacccctg cccctagacc tccaacccca      180

gcccctacaa tcgccagcca gcccctgagc ctgaggcccg aagcctgtag acctgccgct      240

ggcggagccg tgcacaccag aggcctggat ttcgcctgcg ac                         282


<210> 31
<211> 423
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD8 alpha 3x"

<400> 31
aagcctacca ccacccccgc acctcgtcct ccaacccctg cacctacgat tgccagtcag       60

cctctttcac tgcggcctga ggccagcaga ccagctgccg gcggtgccgt ccatacaaga      120

ggactggact tcgcgtccga taaacctact accactccag ccccaaggcc cccaacccca      180

gcaccgacta tcgcatcaca gcctttgtca ctgcgtcctg aagccagccg gccagctgca      240

gggggggccg tccacacaag gggactcgac tttgcgagtg ataagcccac caccacccct      300

gcccctagac ctccaacccc agcccctaca atcgccagcc agcccctgag cctgaggccc      360

gaagcctgta gacctgccgc tggcggagcc gtgcacacca gaggcctgga tttcgcctgc      420

gac                                                                    423


<210> 32
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD8 alpha 4x"

<400> 32
aagcctacca ccacccccgc acctcgtcct ccaacccctg cacctacgat tgccagtcag       60

cctctttcac tgcggcctga ggccagcaga ccagctgccg gcggtgccgt ccatacaaga      120

ggactggact tcgcgtccga taaacctact accactccag ccccaaggcc cccaacccca      180

gcaccgacta tcgcatcaca gcctttgtca ctgcgtcctg aagccagccg gccagctgca      240

gggggggccg tccacacaag gggactcgac tttgcgagtg ataaacctac tacaactcct      300

gccccccggc ctcctacacc agctcctact atcgcctccc agccactcag tctcagaccc      360

gaggcttcta ggccagcggc cggaggcgcg gtccacaccc gcgggctgga ctttgcatcc      420

gataagccca ccaccacccc tgcccctaga cctccaaccc cagcccctac aatcgccagc      480

cagcccctga gcctgaggcc cgaagcctgt agacctgccg ctggcggagc cgtgcacacc      540

agaggcctgg atttcgcctg cgac                                             564


<210> 33
<211> 84
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="CD8-alpha TM domain"

<400> 33
atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgag cctggtcatc       60

accctgtact gcaaccaccg gaat                                              84


<210> 34
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="CD28 TM domain"

<400> 34
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210> 35
<211> 123
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD28 signaling domain"

<400> 35
aggagcaagc ggagcagagg cggccacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggacttcgc cgcctaccgg      120

agc                                                                    123


<210> 36
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD3 zeta signaling domain"

<400> 36
cgggtgaagt tcagccggag cgccgacgcc cctgcctacc agcagggcca gaaccagctg       60

tacaacgagc tgaacctggg ccggagggag gagtacgacg tgctggacaa gcggagaggc      120

cgggaccctg agatgggcgg caagccccgg agaaagaacc ctcaggaggg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

cggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc cccaga                                336


<210> 37
<211> 126
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="4-1BB signaling domain"

<400> 37
aagagaggcc ggaagaaact gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag       60

accacccagg aagaggacgg ctgcagctgc cggttccccg aggaagagga aggcggctgc      120

gaactg                                                                 126


<210> 38
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="DNAX-activation protein 10 (DAP 10) Signaling 
      Domain"

<400> 38
ctgtgcgcac gcccacgccg cagccccgcc caagaagatg gcaaagtcta catcaacatg       60

ccaggcaggg gc                                                           72


<210> 39
<211> 156
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="DNAX-activation protein 12 (DAP12) Signaling 
      Domain"

<400> 39
tacttcctgg gccggctggt ccctcggggg cgaggggctg cggaggcagc gacccggaaa       60

cagcgtatca ctgagaccga gtcgccttat caggagctcc agggtcagag gtcggatgtc      120

tacagcgacc tcaacacaca gaggccgtat tacaaa                                156


<210> 40
<211> 114
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="IL-2 core promoter"

<400> 40
acattttgac acccccataa tatttttcca gaattaacag tataaattgc atctcttgtt       60

caagagttcc ctatcactct ctttaatcac tactcacagt aacctcaact cctg            114


<210> 41
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="IL-2 minimal promoter"

<400> 41
tcaagagttc cctatcactc tctttaatca ctactcacag taacctcaac tcctg            55


<210> 42
<211> 380
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="IL-2 enhancer and promoter variant"

<400> 42
tgatatcttt tctgagttac ttttgtatcc ccaccccctt aaagaaagga ggaaaaactg       60

tttcatacag aaggcgttaa ttgcatgaat tagagctatc acctaagtgt gggctaatgt      120

aacaaagagg gatttcacct acatccattc agtcagtctt tgggggttta aagaaattcc      180

aaagagtcat cagaagagga aaaatgaagg taatgttttt tcagactggt aaagtctttg      240

aaaatatgtg taatatgtaa aacattttga cacccccata atatttttcc agaattaaca      300

gtataaattg catctcttgt tcaagagttc cctatcactc tctttaatca ctactcacag      360

taacctcaac tcctgccaca                                                  380


<210> 43
<211> 373
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="IL-2 enhancer and promoter variant"

<400> 43
ttttctgagt tacttttgta tccccacccc cttaaagaaa ggaggaaaaa ctgtttcata       60

cagaaggcgt taattgcatg aattagagct atcacctaag tgtgggctaa tgtaacaaag      120

agggatttca cctacatcca ttcagtcagt ctttgggggt ttaaagaaat tccaaagagt      180

catcagaaga ggaaaaatga aggtaatgtt ttttcagact ggtaaagtct ttgaaaatat      240

gtgtaatatg taaaacattt tgacaccccc ataatatttt tccagaatta acagtataaa      300

ttgcatctct tgttcaagag ttccctatca ctctctttaa tcactactca cagtaacctc      360

aactcctgcc aca                                                         373


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="NF-kappa-B binding site"

<400> 44
aagagggatt tcacctacat                                                   20


<210> 45
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="NF-kappa-B binding site"

<400> 45
aagagggatt t                                                            11


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="NF-kappa-B binding site"

<400> 46
agagggattt cacctacatc                                                   20


<210> 47
<211> 161
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="(NF-kappa-B)1-IL2 promoter variant"

<400> 47
aattggtccc atcgaagagg gatttcacct acataattgg tcccgggaca ttttgacacc       60

cccataatat ttttccagaa ttaacagtat aaattgcatc tcttgttcaa gagttcccta      120

tcactctctt taatcactac tcacagtaac ctcaactcct g                          161


<210> 48
<211> 201
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="(NF-kappa-B)3-IL2 promoter variant"

<400> 48
aattggtccc atcgaagagg gatttcacct acataagagg gatttcacct acataagagg       60

gatttcacct acataattgg tcccgggaca ttttgacacc cccataatat ttttccagaa      120

ttaacagtat aaattgcatc tcttgttcaa gagttcccta tcactctctt taatcactac      180

tcacagtaac ctcaactcct g                                                201


<210> 49
<211> 268
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="(NF-kappa-B)6-IL2 promoter variant"

<400> 49
aattggtccc atcgaagagg gatttcacct acataagagg gatttcacct acataagagg       60

gatttcacct acataattgg taagagggat ttcacctaca taagagggat ttcacctaca      120

taagagggat ttcacctaca taattggtcc cgggacattt tgacaccccc ataatatttt      180

tccagaatta acagtataaa ttgcatctct tgttcaagag ttccctatca ctctctttaa      240

tcactactca cagtaacctc aactcctg                                         268


<210> 50
<211> 177
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="1X NFAT Response Elements-IL2 Promoter variant"

<400> 50
aattggtccc atcgaattag gaggaaaaac tgtttcatac agaaggcgtc aattggtccc       60

gggacatttt gacaccccca taatattttt ccagaattaa cagtataaat tgcatctctt      120

gttcaagagt tccctatcac tctctttaat cactactcac agtaacctca actcctg         177


<210> 51
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Nuclear factor of activated T-cells (NFAT) 
      response element"

<400> 51
aattaggagg aaaaactgtt tcatacagaa ggcgtc                                 36


<210> 52
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="6X NFAT Response Elements-IL2 Promoter variant"

<400> 52
gaattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa aactgtttca       60

tacagaaggc gtcaattagg aggaaaaact gtttcataca gaaggcgtca attggtccca      120

tcgaattagg aggaaaaact gtttcataca gaaggcgtca attaggagga aaaactgttt      180

catacagaag gcgtcaatta ggaggaaaaa ctgtttcata cagaaggcgt caattggtcc      240

cgggacattt tgacaccccc ataatatttt tccagaatta acagtataaa ttgcatctct      300

tgttcaagag ttccctatca ctctccttaa tcactactca cagtaacctc aactcctg        358


<210> 53
<211> 374
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="6X NFAT Response Elements-IL2 Promoter variant"

<400> 53
tgatatcgaa ttaggaggaa aaactgtttc atacagaagg cgtcaattag gaggaaaaac       60

tgtttcatac agaaggcgtc aattaggagg aaaaactgtt tcatacagaa ggcgtcaatt      120

ggtcccatcg aattaggagg aaaaactgtt tcatacagaa ggcgtcaatt aggaggaaaa      180

actgtttcat acagaaggcg tcaattagga ggaaaaactg tttcatacag aaggcgtcaa      240

ttggtcccgg gacattttga cacccccata atatttttcc agaattaaca gtataaattg      300

catctcttgt tcaagagttc cctatcactc tctttaatca ctactcacag taacctcaac      360

tcctgaattc catg                                                        374


<210> 54
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="6X NFAT Response Elements-IL2 Promoter variant"

<400> 54
gaattaggag gaaaaactgt ttcatacaga aggcgtcaat taggaggaaa aactgtttca       60

tacagaaggc gtcaattagg aggaaaaact gtttcataca gaaggcgtca attggtccca      120

tcgaattagg aggaaaaact gtttcataca gaaggcgtca attaggagga aaaactgttt      180

catacagaag gcgtcaatta ggaggaaaaa ctgtttcata cagaaggcgt caattggtcc      240

cgggacattt tgacaccccc ataatatttt tccagaatta acagtataaa ttgcatctct      300

tgttcaagag ttccctatca ctctctttaa tcactactca cagtaacctc aactcctg        358


<210> 55
<211> 365
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="6X NFAT Response Elements-IL2 Promoter variant"

<400> 55
tgatatcgaa ttaggaggaa aaactgtttc atacagaagg cgtcaattag gaggaaaaac       60

tgtttcatac agaaggcgtc aattaggagg aaaaactgtt tcatacagaa ggcgtcaatt      120

ggtcccatcg aattaggagg aaaaactgtt tcatacagaa ggcgtcaatt aggaggaaaa      180

actgtttcat acagaaggcg tcaattagga ggaaaaactg tttcatacag aaggcgtcaa      240

ttggtcccgg gacattttga cacccccata atatttttcc agaattaaca gtataaattg      300

catctcttgt tcaagagttc cctatcactc tctttaatca ctactcacag taacctcaac      360

tcctg                                                                  365


<210> 56
<211> 256
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="3X NFAT Response Elements-IL2 Promoter variant"

<400> 56
tgatatcaat tggtcccatc gaattaggag gaaaaactgt ttcatacaga aggcgtcaat       60

taggaggaaa aactgtttca tacagaaggc gtcaattagg aggaaaaact gtttcataca      120

gaaggcgtca attggtcccg ggacattttg acacccccat aatatttttc cagaattaac      180

agtataaatt gcatctcttg ttcaagagtt ccctatcact ctctttaatc actactcaca      240

gtaacctcaa ctcctg                                                      256


<210> 57
<211> 249
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="3X NFAT Response Elements-IL2 Promoter variant"

<400> 57
aattggtccc atcgaattag gaggaaaaac tgtttcatac agaaggcgtc aattaggagg       60

aaaaactgtt tcatacagaa ggcgtcaatt aggaggaaaa actgtttcat acagaaggcg      120

tcaattggtc ccgggacatt ttgacacccc cataatattt ttccagaatt aacagtataa      180

attgcatctc ttgttcaaga gttccctatc actctcttta atcactactc acagtaacct      240

caactcctg                                                              249


<210> 58
<211> 244
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="human EEF1A1 promoter variant"

<400> 58
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acag                                                                   244


<210> 59
<211> 236
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="human EEF1A1 promoter variant"

<400> 59
gcgtgaggct ccggtgcccg tcagtgggca gagcgcacat cgcccacagt ccccgagaag       60

ttggggggag gggtcggcaa ttgaaccggt gcctagagaa ggtggcgcgg ggtaaactgg      120

gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg gtgggggaga accgtatata      180

agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt ttgccgccag aacaca          236


<210> 60
<211> 1266
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="human EEF1A1 promoter and enhancer"

<400> 60
gagctttgca aagatggata aagttttaaa cagagaggaa tctttgcagc taatggacct       60

tctaggtctt gaaaggagtg ggaattggct ccggtgcccg tcagtgggca gagcgcacat      120

cgcccacagt ccccgagaag ttggggggag gggtcggcaa ttgaaccggt gcctagagaa      180

ggtggcgcgg ggtaaactgg gaaagtgatg tcgtgtactg gctccgcctt tttcccgagg      240

gtgggggaga accgtatata agtgcagtag tcgccgtgaa cgttcttttt cgcaacgggt      300

ttgccgccag aacacaggta agtgccgtgt gtggttcccg cgggcctggc ctctttacgg      360

gttatggccc ttgcgtgcct tgaattactt ccacctggct gcagtacgtg attcttgatc      420

ccgagcttcg ggttggaagt gggtgggaga gttcgaggcc ttgcgcttaa ggagcccctt      480

cgcctcgtgc ttgagttgag gcctggcctg ggcgctgggg ccgccgcgtg cgaatctggt      540

ggcaccttcg cgcctgtctc gctgctttcg ataagtctct agccatttaa aatttttgat      600

gacctgctgc gacgcttttt ttctggcaag atagtcttgt aaatgcgggc caagatctgc      660

acactggtat ttcggttttt ggggccgcgg gcggcgacgg ggcccgtgcg tcccagcgca      720

catgttcggc gaggcggggc ctgcgagcgc ggccaccgag aatcggacgg gggtagtctc      780

aagctggccg gcctgctctg gtgcctggcc tcgcgccgcc gtgtatcgcc ccgccctggg      840

cggcaaggct ggcccggtcg gcaccagttg cgtgagcgga aagatggccg cttcccggcc      900

ctgctgcagg gagctcaaaa tggaggacgc ggcgctcggg agagcgggcg ggtgagtcac      960

ccacacaaag gaaaagggcc tttccgtcct cagccgtcgc ttcatgtgac tccacggagt     1020

accgggcgcc gtccaggcac ctcgattagt tctcgagctt ttggagtacg tcgtctttag     1080

gttgggggga ggggttttat gcgatggagt ttccccacac tgagtgggtg gagactgaag     1140

ttaggccagc ttggcacttg atgtaattct ccttggaatt tgcccttttt gagtttggat     1200

cttggttcat tctcaagcct cagacagtgg ttcaaagttt ttttcttcca tttcaggtgt     1260

cgtgag                                                                1266


<210> 61
<211> 571
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human UBC promoter"

<400> 61
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc agcgagcgtc ctgatccttc cgcccggacg ctcaggacag      120

cggcccgctg ctcataagac tcggccttag aaccccagta tcagcagaag gacattttag      180

gacgggactt gggtgactct agggcactgg ttttctttcc agagagcgga acaggcgagg      240

aaaagtagtc ccttctcggc gattctgcgg agggatctcc gtggggcggt gaacgccgat      300

gattatataa ggacgcgccg ggtgtggcac agctagttcc gtcgcagccg ggatttgggt      360

cgcggttctt gtttgtggat cgctgtgatc gtcacttggt gagtagcggg ctgctgggct      420

gggtacgtgc gctcggggtt ggcgagtgtg ttttgtgaag ttttttaggc accttttgaa      480

atgtaatcat ttgggtcaat atgtaatttt cagtgttaga ctagtaaatt gtccgctaaa      540

ttctggccgt ttttggcttt tttgttagac g                                     571


<210> 62
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="6 site GAL4-inducible proximal factor binding
      element (PFB)"

<400> 62
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaac                                         148


<210> 63
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Synthetic minimal promoter 1 [Inducible Promoter]"

<400> 63
aggtctatat aagcagagct cgtttagtga accctcattc tggagacgga tcccgagccg       60

agtgttttga cctccataga a                                                 81


<210> 64
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Synthetic 5' UTR based on RPL6"

<400> 64
cagccgctaa atccaaggta aggtcagaag a                                      31


<210> 65
<211> 132
<212> DNA
<213> Simian virus 40

<220>
<221> source
<223> /note="SV40e polyA"

<400> 65
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct gg                                                          132


<210> 66
<211> 275
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Bidirectional aCA polyA [bidirectional polyA]"

<400> 66
atcgattaat ctagcggccc tagacgagca gacatgataa gatacattga tgagtttgga       60

caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt gtgaaatttg tgatgctatt      120

gctttatttg taaccattat aagctgcaat aaacaagtta acaacaacaa ttgcattcat      180

tttatgtttc aggttcaggg ggagatgtgg gaggtttttt aaagcaagta aaacctctac      240

aaatgtggta aaatccgata agcgtaccta gaggc                                 275


<210> 67
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="PA2 polyA"

<400> 67
ggccgcaata aaatatcttt attttcatta catctgtgtg ttggtttttt gtgtgag          57


<210> 68
<211> 258
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VP16 activation domain"

<400> 68
ggccccaaga agaaaaggaa ggtggccccc cccaccgacg tgagcctggg cgacgagctg       60

cacctggacg gcgaggacgt ggccatggcc cacgccgacg ccctggacga cttcgacctg      120

gacatgctgg gcgacggcga cagccccggc cccggcttca ccccccacga cagcgccccc      180

tacggcgccc tggacatggc cgacttcgag ttcgagcaga tgttcaccga cgccctgggc      240

atcgacgagt acggcggc                                                    258


<210> 69
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Retinoid x receptor (RxR)"

<400> 69
gagatgcccg tggacaggat tctggaggcc gaactcgccg tggagcagaa aagcgaccag       60

ggcgtggagg gccccggcgg aaccggcggc agcggcagca gccccaacga ccccgtgacc      120

aacatctgcc aggccgccga caagcagctg ttcaccctgg tggagtgggc caagaggatt      180

ccccacttca gcagcctgcc cctggacgac caggtgatcc tgctgagggc cggatggaac      240

gagctgctga tcgccagctt cagccacagg agcatcgacg tgagggacgg catcctgctg      300

gccaccggcc tgcacgtcca taggaacagc gcccacagcg ccggagtggg cgccatcttc      360

gacagggtgc tgaccgagct ggtgagcaag atgagggaca tgaggatgga caagaccgag      420

ctgggctgcc tgagggccat catcctgttc aaccccgagg tgaggggcct gaaaagcgcc      480

caggaggtgg agctgctgag ggagaaggtg tacgccgccc tggaggagta caccaggacc      540

acccaccccg acgagcccgg cagattcgcc aagctgctgc tgaggctgcc cagcctgagg      600

agcatcggcc tgaagtgcct ggagcacctg ttcttcttca ggctgatcgg cgacgtgccc      660

atcgacacct tcctgatgga gatgctggag agccccagcg acagc                      705


<210> 70
<211> 969
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="VP16-linker-RxR"

<400> 70
ggccccaaga agaaaaggaa ggtggccccc cccaccgacg tgagcctggg cgacgagctg       60

cacctggacg gcgaggacgt ggccatggcc cacgccgacg ccctggacga cttcgacctg      120

gacatgctgg gcgacggcga cagccccggc cccggcttca ccccccacga cagcgccccc      180

tacggcgccc tggacatggc cgacttcgag ttcgagcaga tgttcaccga cgccctgggc      240

atcgacgagt acggcggcga attcgagatg cccgtggaca ggattctgga ggccgaactc      300

gccgtggagc agaaaagcga ccagggcgtg gagggccccg gcggaaccgg cggcagcggc      360

agcagcccca acgaccccgt gaccaacatc tgccaggccg ccgacaagca gctgttcacc      420

ctggtggagt gggccaagag gattccccac ttcagcagcc tgcccctgga cgaccaggtg      480

atcctgctga gggccggatg gaacgagctg ctgatcgcca gcttcagcca caggagcatc      540

gacgtgaggg acggcatcct gctggccacc ggcctgcacg tccataggaa cagcgcccac      600

agcgccggag tgggcgccat cttcgacagg gtgctgaccg agctggtgag caagatgagg      660

gacatgagga tggacaagac cgagctgggc tgcctgaggg ccatcatcct gttcaacccc      720

gaggtgaggg gcctgaaaag cgcccaggag gtggagctgc tgagggagaa ggtgtacgcc      780

gccctggagg agtacaccag gaccacccac cccgacgagc ccggcagatt cgccaagctg      840

ctgctgaggc tgcccagcct gaggagcatc ggcctgaagt gcctggagca cctgttcttc      900

ttcaggctga tcggcgacgt gcccatcgac accttcctga tggagatgct ggagagcccc      960

agcgacagc                                                              969


<210> 71
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="GAL4 DNA Binding Domain"

<400> 71
atgaagctgc tgagcagcat cgagcaggct tgcgacatct gcaggctgaa gaagctgaag       60

tgcagcaagg agaagcccaa gtgcgccaag tgcctgaaga acaactggga gtgcagatac      120

agccccaaga ccaagaggag ccccctgacc agggcccacc tgaccgaggt ggagagcagg      180

ctggagaggc tggagcagct gttcctgctg atcttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctgca agacatcaag gccctgctga ccggcctgtt cgtgcaggac      300

aacgtgaaca aggacgccgt gaccgacagg ctggccagcg tggagaccga catgcccctg      360

accctgaggc agcacaggat cagcgccacc agcagcagcg aggagagcag caacaagggc      420

cagaggcagc tgaccgtgag ccccgagttt                                       450


<210> 72
<211> 1008
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ecdysone Receptor Ligand Binding Domain 
      - VY variant (EcR)"

<400> 72
atcaggcccg agtgcgtggt gcccgagacc cagtgcgcca tgaaaaggaa ggagaagaag       60

gcccagaagg agaaggacaa gctgcccgtg agcaccacca ccgtcgatga ccacatgccc      120

cccatcatgc agtgcgagcc cccccccccc gaggccgcca ggattcacga ggtcgtgccc      180

aggttcctga gcgacaagct gctggtgacc aacaggcaga agaacatccc ccagctgacc      240

gccaaccagc agttcctgat cgccaggctg atctggtatc aggacggcta cgagcagccc      300

agcgacgagg acctgaaaag gatcacccag acctggcagc aggccgacga cgagaacgag      360

gagagcgaca cccccttcag gcagatcacc gagatgacca tcctgaccgt gcagctgatc      420

gtggagttcg ccaagggcct gcccggattc gccaagatca gccagcccga ccagatcacc      480

ctgctgaagg cttgcagcag cgaggtgatg atgctgaggg tggccaggag gtacgacgcc      540

gccagcgaca gcatcctgtt cgccaacaac caggcttaca ccagggacaa ctacaggaag      600

gctggcatgg ccgaggtgat cgaggacctc ctgcacttct gcagatgtat gtacagcatg      660

gccctggaca acatccacta cgccctgctg accgccgtgg tgatcttcag cgacaggccc      720

ggcctggagc agccccagct ggtggaggag atccagaggt actacctgaa caccctgagg      780

atctacatcc tgaaccagct gagcggcagc gccaggagca gcgtgatcta cggcaagatc      840

ctgagcatcc tgagcgagct gaggaccctg ggaatgcaga acagcaatat gtgtatcagc      900

ctgaagctga agaacaggaa gctgcccccc ttcctggagg agatttggga cgtggccgac      960

atgagccaca cccagccccc ccccatcctg gagagcccca ccaacctg                  1008


<210> 73
<211> 1008
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Ecdysone Receptor Ligand Binding Domain 
      - VY variant (EcR)"

<400> 73
cggcctgagt gcgtagtacc cgagactcag tgcgccatga agcggaaaga gaagaaagca       60

cagaaggaga aggacaaact gcctgtcagc acgacgacgg tggacgacca catgccgccc      120

attatgcagt gtgaacctcc acctcctgaa gcagcaagga ttcacgaagt ggtcccaagg      180

tttctctccg acaagctgtt ggtgacaaac cggcagaaaa acatccccca gttgacagcc      240

aaccagcagt tccttatcgc caggctcatc tggtaccagg acgggtacga gcagccttct      300

gatgaagatt tgaagaggat tacgcagacg tggcagcaag cggacgatga aaacgaagag      360

tcggacactc ccttccgcca gatcacagag atgactatcc tcacggtcca acttatcgtg      420

gagttcgcga agggattgcc agggttcgcc aagatctcgc agcctgatca aattacgctg      480

cttaaggctt gctcaagtga ggtaatgatg ctccgagtcg cgcgacgata cgatgcggcc      540

tcagacagta ttctgttcgc gaacaaccaa gcgtacactc gcgacaacta ccgcaaggct      600

ggcatggccg aggtcatcga ggatctactg cacttctgcc ggtgcatgta ctctatggcg      660

ttggacaaca tccattacgc gctgctcacg gctgtcgtca tcttttctga ccggccaggg      720

ttggagcagc cgcaactggt ggaagagatc cagcggtact acctgaatac gctccgcatc      780

tatatcctga accagctgag cgggtcggcg cgttcgtccg tcatatacgg caagatcctc      840

tcaatcctct ctgagctacg cacgctcggc atgcaaaact ccaacatgtg catctccctc      900

aagctcaaga acagaaagct gccgcctttc ctcgaggaga tctgggatgt ggcggacatg      960

tcgcacaccc aaccgccgcc tatcctcgag tcccccacga atctctag                  1008


<210> 74
<211> 1467
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="GAL4-Linker-EcR"

<400> 74
atgaagctac tgtcttctat cgaacaagca tgcgatattt gccgacttaa aaagctcaag       60

tgctccaaag aaaaaccgaa gtgcgccaag tgtctgaaga acaactggga gtgtcgctac      120

tctcccaaaa ccaaaaggtc tccgctgact agggcacatc tgacagaagt ggaatcaagg      180

ctagaaagac tggaacagct atttctactg atttttcctc gagaagacct tgacatgatt      240

ttgaaaatgg attctttaca ggatataaaa gcattgttaa caggattatt tgtacaagat      300

aatgtgaata aagatgccgt cacagataga ttggcttcag tggagactga tatgcctcta      360

acattgagac agcatagaat aagtgcgaca tcatcatcgg aagagagtag taacaaaggt      420

caaagacagt tgactgtatc gccggaattc ccggggatcc ggcctgagtg cgtagtaccc      480

gagactcagt gcgccatgaa gcggaaagag aagaaagcac agaaggagaa ggacaaactg      540

cctgtcagca cgacgacggt ggacgaccac atgccgccca ttatgcagtg tgaacctcca      600

cctcctgaag cagcaaggat tcacgaagtg gtcccaaggt ttctctccga caagctgttg      660

gtgacaaacc ggcagaaaaa catcccccag ttgacagcca accagcagtt ccttatcgcc      720

aggctcatct ggtaccagga cgggtacgag cagccttctg atgaagattt gaagaggatt      780

acgcagacgt ggcagcaagc ggacgatgaa aacgaagagt cggacactcc cttccgccag      840

atcacagaga tgactatcct cacggtccaa cttatcgtgg agttcgcgaa gggattgcca      900

gggttcgcca agatctcgca gcctgatcaa attacgctgc ttaaggcttg ctcaagtgag      960

gtaatgatgc tccgagtcgc gcgacgatac gatgcggcct cagacagtat tctgttcgcg     1020

aacaaccaag cgtacactcg cgacaactac cgcaaggctg gcatggccga ggtcatcgag     1080

gatctactgc acttctgccg gtgcatgtac tctatggcgt tggacaacat ccattacgcg     1140

ctgctcacgg ctgtcgtcat cttttctgac cggccagggt tggagcagcc gcaactggtg     1200

gaagagatcc agcggtacta cctgaatacg ctccgcatct atatcctgaa ccagctgagc     1260

gggtcggcgc gttcgtccgt catatacggc aagatcctct caatcctctc tgagctacgc     1320

acgctcggca tgcaaaactc caacatgtgc atctccctca agctcaagaa cagaaagctg     1380

ccgcctttcc tcgaggagat ctgggatgtg gcggacatgt cgcacaccca accgccgcct     1440

atcctcgagt cccccacgaa tctctag                                         1467


<210> 75
<211> 1464
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="GAL4-Linker-EcR"

<400> 75
atgaagctgc tgagcagcat cgagcaggct tgcgacatct gcaggctgaa gaagctgaag       60

tgcagcaagg agaagcccaa gtgcgccaag tgcctgaaga acaactggga gtgcagatac      120

agccccaaga ccaagaggag ccccctgacc agggcccacc tgaccgaggt ggagagcagg      180

ctggagaggc tggagcagct gttcctgctg atcttcccca gggaggacct ggacatgatc      240

ctgaagatgg acagcctgca agacatcaag gccctgctga ccggcctgtt cgtgcaggac      300

aacgtgaaca aggacgccgt gaccgacagg ctggccagcg tggagaccga catgcccctg      360

accctgaggc agcacaggat cagcgccacc agcagcagcg aggagagcag caacaagggc      420

cagaggcagc tgaccgtgag ccccgagttt cccgggcggc ctgagtgcgt agtacccgag      480

actcagtgcg ccatgaagcg gaaagagaag aaagcacaga aggagaagga caaactgcct      540

gtcagcacga cgacggtgga cgaccacatg ccgcccatta tgcagtgtga acctccacct      600

cctgaagcag caaggattca cgaagtggtc ccaaggtttc tctccgacaa gctgttggtg      660

acaaaccggc agaaaaacat cccccagttg acagccaacc agcagttcct tatcgccagg      720

ctcatctggt accaggacgg gtacgagcag ccttctgatg aagatttgaa gaggattacg      780

cagacgtggc agcaagcgga cgatgaaaac gaagagtcgg acactccctt ccgccagatc      840

acagagatga ctatcctcac ggtccaactt atcgtggagt tcgcgaaggg attgccaggg      900

ttcgccaaga tctcgcagcc tgatcaaatt acgctgctta aggcttgctc aagtgaggta      960

atgatgctcc gagtcgcgcg acgatacgat gcggcctcag acagtattct gttcgcgaac     1020

aaccaagcgt acactcgcga caactaccgc aaggctggca tggccgaggt catcgaggat     1080

ctactgcact tctgccggtg catgtactct atggcgttgg acaacatcca ttacgcgctg     1140

ctcacggctg tcgtcatctt ttctgaccgg ccagggttgg agcagccgca actggtggaa     1200

gagatccagc ggtactacct gaatacgctc cgcatctata tcctgaacca gctgagcggg     1260

tcggcgcgtt cgtccgtcat atacggcaag atcctctcaa tcctctctga gctacgcacg     1320

ctcggcatgc aaaactccaa catgtgcatc tccctcaagc tcaagaacag aaagctgccg     1380

cctttcctcg aggagatctg ggatgtggcg gacatgtcgc acacccaacc gccgcctatc     1440

ctcgagtccc ccacgaatct ctag                                            1464


<210> 76
<211> 1005
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Truncated EGFR (huEGFRt) (Her1t)"

<400> 76
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag      780

acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc      840

ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg gccaggtctt      900

gaaggctgtc caacgaatgg gcctaagatc ccgtccatcg ccactgggat ggtgggggcc      960

ctcctcttgc tgctggtggt ggccctgggg atcggcctct tcatg                     1005


<210> 77
<211> 732
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 1 (Her1 truncated design 1) 
      (HER1t1)"

<400> 77
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctctggtg gcggtggctc gggcggtggt      600

gggtcgggtg gcggcggatc tggtggcggt ggctcgtttt gggtgctggt ggtggttggt      660

ggagtcctgg cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg      720

agtaagagga gc                                                          732


<210> 78
<211> 771
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 2 (Her1 truncated design 2) 
      (HER1t2)"

<400> 78
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagggtgg cggtggctcg ggcggtggtg ggtcgggtgg cggcggatct      660

ggtggcggtg gctcgttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc      720

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag c               771


<210> 79
<211> 828
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 3 (Her1 truncated design 3) 
      (HER1t3)"

<400> 79
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agggtggcgg tggctcgggc ggtggtgggt cgggtggcgg cggatctggt      720

ggcggtggct cgttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg      780

ctagtaacag tggcctttat tattttctgg gtgaggagta agaggagc                   828


<210> 80
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 4 (Her1 truncated design 4) 
      (HER1t4)"

<400> 80
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagggcgga ggcggaagcg gaggcggagg ctccggcgga      780

ggcggaagct tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      840

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagc                      885


<210> 81
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 5 (Her1 truncated design 5) 
      (HER1t5)"

<400> 81
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag      780

accggcggag gcggaagcgg aggcggaggc tccggcggag gcggaagctt ttgggtgctg      840

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      900

ttctgggtga ggagtaagag gagc                                             924


<210> 82
<211> 984
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 6 (Her1 truncated design 6) 
      (HER1t6)"

<400> 82
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag      780

acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc      840

ggccatgtgt gccacctggg cggaggcgga agcggaggcg gaggctcctt ttgggtgctg      900

gtggtggttg gtggagtcct ggcttgctat agcttgctag taacagtggc ctttattatt      960

ttctgggtga ggagtaagag gagc                                             984


<210> 83
<211> 1032
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 7 (Her1 truncated design 7) 
      (HER1t7)"

<400> 83
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctcttgcc ggaatgtcag ccgaggcagg      600

gaatgcgtgg acaagtgcaa ccttctggag ggtgagccaa gggagtttgt ggagaactct      660

gagtgcatac agtgccaccc agagtgcctg cctcaggcca tgaacatcac ctgcacagga      720

cggggaccag acaactgtat ccagtgtgcc cactacattg acggccccca ctgcgtcaag      780

acctgcccgg caggagtcat gggagaaaac aacaccctgg tctggaagta cgcagacgcc      840

ggccatgtgt gccacctgtg ccatccaaac tgcacctacg gatgcactgg gccaggtctt      900

gaaggctgtc caggtggcgg tggcggcgga tctttttggg tgctggtggt ggttggtgga      960

gtcctggctt gctatagctt gctagtaaca gtggccttta ttattttctg ggtgaggagt     1020

aagaggagct aa                                                         1032


<210> 84
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 8 (Her1 truncated design 8) 
      (HER1t8)"

<400> 84
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctctggtg gcggtggctc gggcggtggt      600

gggtcgggtg gcggcggatc tggtggcggt ggctcggaga taacactcat tatttttggg      660

gtgatggctg gtgttattgg aacgatcctc ttaatttctt acggtattcg ccgaggaggt      720

ggaagc                                                                 726


<210> 85
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 9 (Her1 truncated design 9) 
      (HER1t9)"

<400> 85
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctctggtg gcggtggctc gggcggtggt      600

gggtcgggtg gcggcggatc tggtggcggt ggctcgataa cactcattat ttttggggtg      660

atggctggtg ttattggaac gatcctctta atttcttacg gtattggagg tggaagc         717


<210> 86
<211> 717
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 10 (Her1 truncated design 10) 
      (HER1t10)"

<400> 86
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctctggtg gcggtggctc gggcggtggt      600

gggtcgggtg gcggcggatc tggtggcggt ggctcgataa cactcattat ttttggggtg      660

atggctggtg ttattggaac gatcctctta gccctgctca tctggggagg tggaagc         717


<210> 87
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR truncated design 11 (Her1 truncated design 11) 
      (HER1t11)"

<400> 87
cgcaaagtgt gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct       60

acgaatatta aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg      120

gtggcattta ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat      180

attctgaaaa ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac      240

aggacggacc tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat      300

ggtcagtttt ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc      360

aaggagataa gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat      420

acaataaact ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac      480

agaggtgaaa acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag      540

ggctgctggg gcccggagcc cagggactgc gtctctggtg gcggtggctc gggcggtggt      600

gggtcgggtg gcggcggatc tggtggcggt ggctcgctct gctacctgct ggatggaatc      660

ctcttcatct atggtgtcat tctcactgcc ttgttcctgg gaggtggaag c               711


<210> 88
<211> 891
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FL CD20"

<400> 88
atgacaacac ccagaaattc agtaaatggg actttcccgg cagagccaat gaaaggccct       60

attgctatgc aatctggtcc aaaaccactc ttcaggagga tgtcttcact ggtgggcccc      120

acgcaaagct tcttcatgag ggaatctaag actttggggg ctgtccagat tatgaatggg      180

ctcttccaca ttgccctggg gggtcttctg atgatcccag cagggatcta tgcacccatc      240

tgtgtgactg tgtggtaccc tctctgggga ggcattatgt atattatttc cggatcactc      300

ctggcagcaa cggagaaaaa ctccaggaag tgtttggtca aaggaaaaat gataatgaat      360

tcattgagcc tctttgctgc catttctgga atgattcttt caatcatgga catacttaat      420

attaaaattt cccatttttt aaaaatggag agtctgaatt ttattagagc tcacacacca      480

tatattaaca tatacaactg tgaaccagct aatccctctg agaaaaactc cccatctacc      540

caatactgtt acagcataca atctctgttc ttgggcattt tgtcagtgat gctgatcttt      600

gccttcttcc aggaacttgt aatagctggc atcgttgaga atgaatggaa aagaacgtgc      660

tccagaccca aatctaacat agttctcctg tcagcagaag aaaaaaaaga acagactatt      720

gaaataaaag aagaagtggt tgggctaact gaaacatctt cccaaccaaa gaatgaagaa      780

gacattgaaa ttattccaat ccaagaagag gaagaagaag aaacagagac gaactttcca      840

gaacctcccc aagatcagga atcctcacca atagaaaatg acagctctcc t               891


<210> 89
<211> 789
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Truncated CD20 design 1 (CD20t1) [CD20(M1-E263]"

<400> 89
atgaccacac cacggaactc tgtgaatggc accttcccag cagagccaat gaagggacca       60

atcgcaatgc agagcggacc caagcctctg tttcggagaa tgagctccct ggtgggccca      120

acccagtcct tctttatgag agagtctaag acactgggcg ccgtgcagat catgaacgga      180

ctgttccaca tcgccctggg aggactgctg atgatcccag ccggcatcta cgcccctatc      240

tgcgtgaccg tgtggtaccc tctgtggggc ggcatcatgt atatcatctc cggctctctg      300

ctggccgcca cagagaagaa cagcaggaag tgtctggtga agggcaagat gatcatgaat      360

agcctgtccc tgtttgccgc catctctggc atgatcctga gcatcatgga catcctgaac      420

atcaagatca gccacttcct gaagatggag agcctgaact tcatcagagc ccacacccct      480

tacatcaaca tctataattg cgagcctgcc aacccatccg agaagaattc tccaagcaca      540

cagtactgtt attccatcca gtctctgttc ctgggcatcc tgtctgtgat gctgatcttt      600

gccttctttc aggagctggt catcgccggc atcgtggaga acgagtggaa gaggacctgc      660

agccgcccca agtccaatat cgtgctgctg tccgccgagg agaagaagga gcagacaatc      720

gagatcaagg aggaggtggt gggcctgacc gagacatcta gccagcctaa gaatgaggag      780

gatatcgag                                                              789


<210> 90
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Interleukin-15"

<400> 90
aactgggtga atgtgatcag cgacctgaag aagatcgagg atctgatcca gagcatgcac       60

attgatgcca ccctgtacac agaatctgat gtgcacccta gctgtaaagt gaccgccatg      120

aagtgttttc tgctggagct gcaggtgatt tctctggaaa gcggagatgc ctctatccac      180

gacacagtgg agaatctgat catcctggcc aacaatagcc tgagcagcaa tggcaatgtg      240

acagagtctg gctgtaagga gtgtgaggag ctggaggaga agaacatcaa ggagtttctg      300

cagagctttg tgcacatcgt gcagatgttc atcaatacaa gc                         342


<210> 91
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Interleukin-15 receptor alpha"

<400> 91
attacatgcc ctcctccaat gtctgtggag cacgccgata tttgggtgaa gtcctacagc       60

ctgtacagca gagagagata catctgcaac agcggcttta agagaaaggc cggcacctct      120

tctctgacag agtgcgtgct gaataaggcc acaaatgtgg cccactggac aacacctagc      180

ctgaagtgca ttagagatcc tgccctggtc caccagaggc ctgcccctcc atctacagtg      240

acaacagccg gagtgacacc tcagcctgaa tctctgagcc cttctggaaa agaacctgcc      300

gccagctctc ctagctctaa taataccgcc gccacaacag ccgccattgt gcctggatct      360

cagctgatgc ctagcaagtc tcctagcaca ggcacaacag agatcagcag ccacgaatct      420

tctcacggaa caccttctca gaccaccgcc aagaattggg agctgacagc ctctgcctct      480

caccagcctc caggagtgta tcctcagggc cactctgata caacagtggc catcagcaca      540

tctacagtgc tgctgtgtgg actgtctgcc gtgtctctgc tggcctgtta cctgaagtct      600

agacagacac ctcctctggc ctctgtggag atggaggcca tggaagccct gcctgtgaca      660

tggggaacaa gcagcagaga tgaggacctg gagaattgtt ctcaccacct g               711


<210> 92
<211> 1185
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Membrane bound Interleukin-15 with signal peptide"

<400> 92
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagcaactgg       60

gtgaatgtga tcagcgacct gaagaagatc gaggatctga tccagagcat gcacattgat      120

gccaccctgt acacagaatc tgatgtgcac cctagctgta aagtgaccgc catgaagtgt      180

tttctgctgg agctgcaggt gatttctctg gaaagcggag atgcctctat ccacgacaca      240

gtggagaatc tgatcatcct ggccaacaat agcctgagca gcaatggcaa tgtgacagag      300

tctggctgta aggagtgtga ggagctggag gagaagaaca tcaaggagtt tctgcagagc      360

tttgtgcaca tcgtgcagat gttcatcaat acaagctctg gcggaggatc tggaggaggc      420

ggatctggag gaggaggcag tggaggcgga ggatctggcg gaggatctct gcagattaca      480

tgccctcctc caatgtctgt ggagcacgcc gatatttggg tgaagtccta cagcctgtac      540

agcagagaga gatacatctg caacagcggc tttaagagaa aggccggcac ctcttctctg      600

acagagtgcg tgctgaataa ggccacaaat gtggcccact ggacaacacc tagcctgaag      660

tgcattagag atcctgccct ggtccaccag aggcctgccc ctccatctac agtgacaaca      720

gccggagtga cacctcagcc tgaatctctg agcccttctg gaaaagaacc tgccgccagc      780

tctcctagct ctaataatac cgccgccaca acagccgcca ttgtgcctgg atctcagctg      840

atgcctagca agtctcctag cacaggcaca acagagatca gcagccacga atcttctcac      900

ggaacacctt ctcagaccac cgccaagaat tgggagctga cagcctctgc ctctcaccag      960

cctccaggag tgtatcctca gggccactct gatacaacag tggccatcag cacatctaca     1020

gtgctgctgt gtggactgtc tgccgtgtct ctgctggcct gttacctgaa gtctagacag     1080

acacctcctc tggcctctgt ggagatggag gccatggaag ccctgcctgt gacatgggga     1140

acaagcagca gagatgagga cctggagaat tgttctcacc acctg                     1185


<210> 93
<211> 1605
<212> DNA
<213> Mus sp.

<220>
<221> source
<223> /note="Murine single chain IL-12 (p40-linker-p35)"

<400> 93
atgtgtcctc agaagctaac catctcctgg tttgccatcg ttttgctggt gtctccactc       60

atggccatgt gggagctgga gaaagacgtt tatgttgtag aggtggactg gactcccgat      120

gcccctggag aaacagtgaa cctcacctgt gacacgcctg aagaagatga catcacctgg      180

acctcagacc agagacatgg agtcataggc tctggaaaga ccctgaccat cactgtcaaa      240

gagtttctag atgctggcca gtacacctgc cacaaaggag gcgagactct gagccactca      300

catctgctgc tccacaagaa ggaaaatgga atttggtcca ctgaaattct gaagaacttc      360

aaaaacaaga ctttcctgaa gtgtgaagca ccaaattaca gcggccggtt cacgtgctca      420

tggctggtgc aaagaaacat ggacttgaag ttcaacatca agagcagtag cagttcccct      480

gactctcggg cagtgacatg tggaatggcg tctctgagcg ccgagaaggt cacactggac      540

cagagagact atgagaagta ttcagtgtcc tgccaggagg atgtcacctg cccaactgcc      600

gaggagaccc tgcccattga actggcgttg gaagcacggc agcagaacaa gtatgagaac      660

tacagcacca gcttcttcat cagggacatc atcaaaccag acccgcccaa gaacttgcag      720

atgaagcctt tgaagaactc acaggtggag gtcagctggg agtaccctga ctcctggagc      780

actccccatt cctacttctc cctcaagttc tttgtgagaa tccagcgcaa gaaagaaaag      840

atgaaggaga cagaggaggg gtgtaaccag aaaggtgcgt tcctcgtaga gaagacatct      900

accgaagtcc aatgcaaagg cgggaatgtc tgcgtgcaag ctcaggatcg ctattacaat      960

tcctcatgca gcaagtgggc atgtgttccc tgccgcgtcc gatccggtgg cggtggcggc     1020

ggatctaggg tcattccagt ctctggacct gccaggtgtc ttagccagtc ccgaaacctg     1080

ctgaagacca cagatgacat ggtgaagacg gccagagaaa aactgaaaca ttattcctgc     1140

actgctgaag acattgacca tgaagacatc acacgggacc aaaccagcac attgaagacc     1200

tgtttaccac tggaactaca caagaacgag agttgcctgg ctactagaga gacttcttcc     1260

acaacaagag ggagctgcct gcccccacag aagaccagct tgatgatgac cctgtgcctt     1320

ggtagcatct atgaggactt gaagatgtac cagacagagt tccaggccat caacgcagca     1380

cttcagaatc acaaccatca gcagatcatt ctagacaagg gcatgttggt ggccatcgac     1440

gagctgatgc agtctctgaa tcataatggc gagactctgc gccagaaacc tcctgtggga     1500

gaagcagacc cttacagagt gaaaatgaag ctctgcatcc tgcttcacgc cttcagcacc     1560

cgcgtcgtga ccatcaacag ggtgatgggc tatctgagca gcgcc                     1605


<210> 94
<211> 1596
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human single chain IL-12 (p40-linker-p35)"

<400> 94
atgtgtcacc agcagttggt catctcttgg ttcagcctgg tttttctggc atctcccctc       60

gtggccatct gggaactgaa gaaagatgtt tatgtcgtag aattggattg gtatcccgac      120

gcccctggag aaatggtggt cctgacatgt gacacccctg aagaagatgg tatcacctgg      180

accttggacc agagcagtga ggtcttaggc tctggcaaga ccctgaccat ccaagtcaaa      240

gagtttggag atgctggcca gtacacctgt cacaaaggag gcgaggttct aagccattcg      300

ctcctgctgc ttcacaaaaa ggaagatgga atttggtcca ctgacattct gaaggaccag      360

aaagaaccca agaataagac ctttctaaga tgcgaggcca agaattattc tggacgtttc      420

acctgctggt ggctgacgac aatcagtact gatttgacat tcagtgtcaa aagcagcaga      480

ggctcttctg acccccaagg ggtgacgtgc ggagctgcta cactcagcgc cgagagagtc      540

agaggggaca acaaggagta tgagtactca gtggagtgcc aggaggacag tgcctgccca      600

gctgctgagg agagtctgcc cattgaggtc atggtggatg ccgttcacaa gctcaagtat      660

gaaaactaca ccagcagctt cttcatcagg gacatcatca aacctgaccc acccaagaac      720

ttgcagctga agcccctgaa gaacagcaga caggtggagg tcagctggga gtaccctgac      780

acctggagta ctccacattc ctacttctcc ctgacattct gcgttcaggt ccagggcaag      840

agcaagagag aaaagaaaga tagagtcttc acggacaaga cctcagccac ggtcatctgc      900

cgcaaaaatg ccagcattag cgtgcgggcc caggaccgct actatagctc atcttggagc      960

gaatgggcat ctgtgccctg ctccggtggc ggtggcggcg gatctagaaa cctccccgtg     1020

gccactccag acccaggaat gttcccatgc cttcaccaca gccagaacct gctgagggcc     1080

gtcagcaaca tgctccagaa ggccagacaa actctagaat tttacccttg cacttctgaa     1140

gagattgatc atgaagatat cacaaaagat aaaaccagca cagtggaggc ctgtttacca     1200

ttggaattaa ccaagaatga gagttgccta aattccagag agacctcttt cataactaat     1260

gggagttgcc tggcctccag aaagacctct tttatgatgg ccctgtgcct tagtagtatt     1320

tatgaagact tgaagatgta ccaggtggag ttcaagacca tgaatgcaaa gctgctgatg     1380

gaccccaaga ggcagatctt tctagatcaa aacatgctgg cagttattga tgagctgatg     1440

caggccctga atttcaacag tgagactgtg ccacaaaaat cctcccttga agaaccggat     1500

ttttataaaa ctaaaatcaa gctctgcata cttcttcatg ctttcagaat cagagcagtg     1560

actattgata gagtgatgag ctatctgaat gcttcc                               1596


<210> 95
<211> 6684
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="Human interleukin-2 (IL-2) gene and 5'-flanking 
      region"

<400> 95
agtggttttt ggagtcagta cattctcttt tcaaatcctt ctctgcccct tactggcaat       60

aagggctgag tgacctagag gcaaattact taacttctct gagcctcagt tttctaatct      120

gcaaaatagg agccatcact tcacaagtct gtaagactta tattagacta agtgcctgcc      180

tgtacactgt tctctttttc tctctttcta tatacctgaa ggcattatag tgctagatgt      240

ctgtttaaag accagacaat attgtcttaa aaaaacaaac aaaaacacag acaataccat      300

ctttaaaaaa aaaaaaaaag tccaggtaag aaataaataa ggccatagaa tggaagcttt      360

acaaggactc tctttgagac aggatctcct caagtgtccc caggttaaat tagaagtata      420

tatccgtaca attgttcagc cagtttgtgc actgtactga ggatgaatga acacctatcc      480

taaatatcct agtcttctga ctaaaaacaa gatcatattt cataacgatt attgttacat      540

tcatagtgtc ccaggtgatt tagaggataa ataaaaatcc attaaagagg taaagacata      600

aaaacgagaa acatggactg gtttacacat aacacataca aagtctatta taaaactagc      660

atcagtatcc ttgaatcgaa acctttttct gagtatttaa caatcgcacc ctttaaaaaa      720

tgtacataga cattaagaga cttaaacaga tatataatca ttttaaatta aaatagcgtt      780

aaacagtacc tcaagctcaa taagcatttt aagtattcta atcttagtat ttctctagct      840

gacatgtaag aagcaatcta tcttattgta tgcaattagc tctttgtgtg gataaaaagg      900

taaaaccatt ctgaaacagg aaaccaatac acttcctgtt taatcaacaa atctaaacat      960

ttattctttt catctgttta ctcttgctct tgtccaccac aatatgctat tcacatgttc     1020

agtgtagttt tatgacaaag aaaattttct gagttacttt tgtatcccca cccccttaaa     1080

gaaaggagga aaaactgttt catacagaag gcgttaattg catgaattag agctatcacc     1140

taagtgtggg ctaatgtaac aaagagggat ttcacctaca tccattcagt cagtctttgg     1200

gggtttaaag aaattccaaa gagtcatcag aagaggaaaa atgaaggtaa tgttttttca     1260

gactggtaaa gtctttgaaa atatgtgtaa tatgtaaaac attttgacac ccccataata     1320

tttttccaga attaacagta taaattgcat ctcttgttca agagttccct atcactcttt     1380

aatcactact cacagtaacc tcaactcctg ccacaatgta caggatgcaa ctcctgtctt     1440

gcattgcact aagtcttgca cttgtcacaa acagtgcacc tacttcaagt tctacaaaga     1500

aaacacagct acaactggag catttactgc tggatttaca gatgattttg aatggaatta     1560

atgtaagtat atttcctttc ttactaaaat tattacattt agtaatctag ctggagatca     1620

tttcttaata acaatgcatt atactttctt agaattacaa gaatcccaaa ctcaccagga     1680

tgctcacatt taagttttac atgcccaaga aggtaagtac aatattttat gttcaatttc     1740

tgttttaata aaattcaaag taatatgaaa atttgcacag atgggactaa tagcagctca     1800

tctgaggtaa agagtaactt taatttgttt ttttgaaaac ccaagtttga taatgaagcc     1860

tctattaaaa cagttttacc tatattttta atatatattt gtgtgttggt gggggtggga     1920

gaaaacataa aaataatatt ctctcacttt atcgataaga caattctaaa caaaaatgtt     1980

catttatggt ttcatttaaa aatgtaaaac tctaaaatat ttgattatgt cattttagta     2040

tgtaaaatac caaaatctat ttccaaggag cccactttta aaaatctttt cttgttttag     2100

gaaaggtttc taagtgagag gcagcataac actaatagca cagagtctgg ggccagatat     2160

ctgaagtgaa atctcagctc tgccatgtcc tagctttcat gatctttggc aaattaccta     2220

ctctgtttgt gattcagttt catgtctact taaatgaata actgtatata cttaatatgg     2280

ctttgtgaga attagtaagt aaatgtaaag cactcagaac cgtgtctggc ataaggtaaa     2340

taccatacaa gcattagcta ttattagtag tattaaagat aaaattttca ctgagaaata     2400

caaagtaaaa ttttggactt tatcttttta ccaatagaac ttgagattta taatgctata     2460

tgacttattt tccaagatta aaagcttcat taggttgttt ttggattcag atagagcata     2520

agcataatca tccaagctcc taggctacat taggtgtgta aagctaccta gtagctgtgc     2580

cagttaagag agaatgaaca aaatctggtg ccagaaagag cttgtgccag ggtgaatcca     2640

agcccagaaa ataataggat ttaaggggac acagatgcaa tcccattgac tcaaattcta     2700

ttaattcaag acaaatctgc ttctaactac ccttctgaaa gatgtaaagg agacagctta     2760

cagatgttac tctagtttaa tcagagccac ataatgcaac tccagcaaca taaagatact     2820

agatgctgtt ttctgaagaa aatttctcca cattgttcat gccaaaaact taaacccgaa     2880

tttgtagaat ttgtagtggt gaattgaaag cgcaatagat ggacatatca ggggattggt     2940

attgtcttga cctacctttc ccactaaaga gtgttagaaa gatgagatta tgtgcataat     3000

ttaggggtgg tagaattcat ggaaatctaa gtttgaaacc aaaagtaatg ataaactcta     3060

ttcatttgtt catttaaccc tcattgcaca tttacaaaag attttagaaa ctaataaaaa     3120

tatttgattc caaggatgct atgttaatgc tataatgaga aagaaatgaa atctaattct     3180

ggctctacct acttatgtgg tcaaattctg agatttagtg tgcttattta taaagtggag     3240

atgatacttc actgcctact tcaaaagatg actgtgagaa gtaaatgggc ctattttgga     3300

gaaaattctt ttaaattgta atataccata gaaatatgaa atattatata taatatagaa     3360

tcaagaggcc tgtccaaaag tcctcccaaa gtattataat cttttatttc actgggacaa     3420

acatttttaa aatgcatctt aatgtagtga ttgtagaaaa gtaaaaattt aagacatatt     3480

taaaaatgtg tcttgctcaa ggctatattg agagccacta ctacatgatt attgttacct     3540

agtgtaaaat gttgggattg tgatagatgg catccaagag ttccttctct ctcaacattc     3600

tgtgattctt aactcttaga ctatcaaata ttataatcat agaatgtgat ttttatgcct     3660

tccacattct aatctcatct ggttctaatg attttctatg cagattggaa aagtaatcag     3720

cctacatctg taataggcat ttagatgcag aaagtctaac attttgcaaa gccaaattaa     3780

gctaaaacca gtgagtcaac tatcacttaa cgctagtcat aggtacttga gccctagttt     3840

ttccagtttt ataatgtaaa ctctactggt ccatctttac agtgacattg agaacagaga     3900

gaatggtaaa aactacatac tgctactcca aataaaataa attggaaatt aatttctgat     3960

tctgacctct atgtaaactg agctgatgat aattattatt ctaggccaca gaactgaaac     4020

atcttcagtg tctagaagaa gaactcaaac ctctggagga agtgctaaat ttagctcaaa     4080

gcaaaaactt tcacttaaga cccagggact taatcagcaa tatcaacgta atagttctgg     4140

aactaaaggt aaggcattac tttatttgct ctcctggaaa taaaaaaaaa aaagtagggg     4200

gaaaagtacc acattttaaa gtgacataac atttttggta tttgtaaagt acccatgcat     4260

gtaattagcc tacattttaa gtacactgtg aacatgaatc atttctaatg ttaaatgatt     4320

aactggggag tataagctac tgagtttgca cctaccatct actaatggac aagcctcatc     4380

ccaaactcca tcacctttca tattaacaca aaactgggag tgagagagaa gtgactgagt     4440

tgagtttcac agaaacgcag gcaagatttt attatatatt tttcaagttc cttcacagat     4500

catttactgg aatagccaat actgagttac ctgaaaggct tttcaaatgg tgtttcctta     4560

tcatttgatg gaaggactac ccataagaga tttgtcttaa aaaaaaaaac tggagccatt     4620

aaaatggcca gtggactaaa caaacaacaa tctttttaga ggcaatccca ctttcagaat     4680

cttaagtatt tttaaatgca caggaagcat aaaatatgca agggactcag gtgatgtaaa     4740

agagattcac ttttgtcttt ttatatcccg tctcctaagg tataaaattc atgagttaat     4800

aggtatccta aataagcagc ataagtatag tagtaaaaga cattcctaaa agtaactcca     4860

gttgtgtcca aatgaatcac ttattagtgg actgtttcag ttgaattaaa aaaatacatt     4920

gagatcaatg tcatctagac attgacagat tcagttcctt atctatggca agagttttac     4980

tctaaaataa ttaacatcag aaaactcatt cttaactctt gatacaaatt taagacaaaa     5040

ccatgcaaaa atctgaaaac tgtgtttcaa aagccaaaca ctttttaaaa taaaaaaatc     5100

ccaagatatg acaatattta aacaattatg cttaagagga tacagaacac tgcaacagtt     5160

ttttaaaaga gaatacttat ttaaagggaa cactctatct cacctgcttt tgttcccagg     5220

gtaggaatca cttcaaattt gaaaagctct cttttaaatc tcactatata tcaaaatagt     5280

tgcctcctta gcttatcaac tagaggaagc gtttaaatag ctcctttcag cagagaagcc     5340

taatttctaa aaagccagtc cacagaacaa aatttctaat gtttaaagct tttaaaagtt     5400

ggcaaattca cctgcattga tactatgatg gggtagggat aggtgtaagt atttatgaag     5460

atgttcattc acacaaattt acccaaacag gaagcatgtc ctacctagct tactctagtg     5520

tagctcgttt cgtctttggg gaaaatataa ggagattcac ttaagtagaa aaataggaga     5580

ctctaatcaa gatttagaaa agaagaaagt ataatgtgca tatcaattca tacatttaac     5640

ttacacaaat ataggtgtac attcagagga aaagcgatca agtttatttc acatccagca     5700

tttaatattt gtctagatct atttttattt aaatctttat ttgcacccaa tttagggaaa     5760

aaatttttgt gttcattgac tgaattaaca aatgaggaaa atctcagctt ctgtgttact     5820

atcatttggt atcataacaa aatacgcaat tttggcattc attttgatca tttcaagaaa     5880

atgtgaataa ttaatatgtt tggtaagctt gaaaataaag gcaacaggcc tataagactt     5940

caattgggaa taactgtata taaggtaaac tactctgtac tttaaaaaat taacattttt     6000

cttttatagg gatctgaaac aacattcatg tgtgaatatg ctgatgagac agcaaccatt     6060

gtagaatttc tgaacagatg gattaccttt tgtcaaagca tcatctcaac actgacttga     6120

taattaagtg cttcccactt aaaacatatc aggccttcta tttatttaaa tatttaaatt     6180

ttatatttat tgttgaatgt atggtttgct acctattgta actattattc ttaatcttaa     6240

aactataaat atggatcttt tatgattctt tttgtaagcc ctaggggctc taaaatggtt     6300

tcacttattt atcccaaaat atttattatt atgttgaatg ttaaatatag tatctatgta     6360

gattggttag taaaactatt taataaattt gataaatata aacaagcctg gatatttgtt     6420

attttggaaa cagcacagag taagcattta aatatttctt agttacttgt gtgaactgta     6480

ggatggttaa aatgcttaca aaagtcactc tttctctgaa gaaatatgta gaacagagat     6540

gtagacttct caaaagccct tgctttgtcc tttcaagggc tgatcagacc cttagttctg     6600

gcatctctta gcagattata ttttccttct tcttaaaatg ccaaacacaa acactcttga     6660

aactcttcat agatttggtg tggc                                            6684


<210> 96
<211> 1419
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD19-specific chimeric antigen receptor 
      (CD19-CD8a-CD28-CD3z)"

<400> 96
gacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc       60

atcagctgcc gggccagcca ggacatcagc aagtacctga actggtatca gcagaagccc      120

gacggcaccg tcaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggagcag      240

gaggacatcg ccacctactt ttgccagcag ggcaacacac tgccctacac ctttggcggc      300

ggaacaaagc tggagatcac cggcagcacc tccggcagcg gcaagcctgg cagcggcgag      360

ggcagcacca agggcgaggt gaagctgcag gagagcggcc ctggcctggt ggcccccagc      420

cagagcctga gcgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      480

tggatccggc agccccctag gaagggcctg gagtggctgg gcgtgatctg gggcagcgag      540

accacctact acaacagcgc cctgaagagc cggctgacca tcatcaagga caacagcaag      600

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgt      660

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      720

gtgaccgtgt ccagcaagcc caccaccacc cctgccccta gacctccaac cccagcccct      780

acaatcgcca gccagcccct gagcctgagg cccgaagcct gtagacctgc cgctggcgga      840

gccgtgcaca ccagaggcct ggatttcgcc tgcgacatct acatctgggc ccctctggcc      900

ggcacctgtg gcgtgctgct gctgagcctg gtcatcaccc tgtactgcaa ccaccggaat      960

aggagcaagc ggagcagagg cggccacagc gactacatga acatgacccc ccggaggcct     1020

ggccccaccc ggaagcacta ccagccctac gcccctccca gggacttcgc cgcctaccgg     1080

agccgggtga agttcagccg gagcgccgac gcccctgcct accagcaggg ccagaaccag     1140

ctgtacaacg agctgaacct gggccggagg gaggagtacg acgtgctgga caagcggaga     1200

ggccgggacc ctgagatggg cggcaagccc cggagaaaga accctcagga gggcctgtat     1260

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggcat gaagggcgag     1320

cggcggaggg gcaagggcca cgacggcctg taccagggcc tgagcaccgc caccaaggat     1380

acctacgacg ccctgcacat gcaggccctg ccccccaga                            1419


<210> 97
<211> 1485
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="CD19-specific chimeric antigen receptor 
      (CD19-CD8a-CD28-CD3z) with Signal peptide"

<400> 97
atgctgctgc tggtgaccag cctgctgctg tgtgagctgc cccaccccgc ctttctgctg       60

atccccgaca tccagatgac ccagaccacc tccagcctga gcgccagcct gggcgaccgg      120

gtgaccatca gctgccgggc cagccaggac atcagcaagt acctgaactg gtatcagcag      180

aagcccgacg gcaccgtcaa gctgctgatc taccacacca gccggctgca cagcggcgtg      240

cccagccggt ttagcggcag cggctccggc accgactaca gcctgaccat ctccaacctg      300

gagcaggagg acatcgccac ctacttttgc cagcagggca acacactgcc ctacaccttt      360

ggcggcggaa caaagctgga gatcaccggc agcacctccg gcagcggcaa gcctggcagc      420

ggcgagggca gcaccaaggg cgaggtgaag ctgcaggaga gcggccctgg cctggtggcc      480

cccagccaga gcctgagcgt gacctgtacc gtgtccggcg tgtccctgcc cgactacggc      540

gtgtcctgga tccggcagcc ccctaggaag ggcctggagt ggctgggcgt gatctggggc      600

agcgagacca cctactacaa cagcgccctg aagagccggc tgaccatcat caaggacaac      660

agcaagagcc aggtgttcct gaagatgaac agcctgcaga ccgacgacac cgccatctac      720

tactgtgcca agcactacta ctacggcggc agctacgcca tggactactg gggccagggc      780

accagcgtga ccgtgtccag caagcccacc accacccctg cccctagacc tccaacccca      840

gcccctacaa tcgccagcca gcccctgagc ctgaggcccg aagcctgtag acctgccgct      900

ggcggagccg tgcacaccag aggcctggat ttcgcctgcg acatctacat ctgggcccct      960

ctggccggca cctgtggcgt gctgctgctg agcctggtca tcaccctgta ctgcaaccac     1020

cggaatagga gcaagcggag cagaggcggc cacagcgact acatgaacat gaccccccgg     1080

aggcctggcc ccacccggaa gcactaccag ccctacgccc ctcccaggga cttcgccgcc     1140

taccggagcc gggtgaagtt cagccggagc gccgacgccc ctgcctacca gcagggccag     1200

aaccagctgt acaacgagct gaacctgggc cggagggagg agtacgacgt gctggacaag     1260

cggagaggcc gggaccctga gatgggcggc aagccccgga gaaagaaccc tcaggagggc     1320

ctgtataacg aactgcagaa agacaagatg gccgaggcct acagcgagat cggcatgaag     1380

ggcgagcggc ggaggggcaa gggccacgac ggcctgtacc agggcctgag caccgccacc     1440

aaggatacct acgacgccct gcacatgcag gccctgcccc ccaga                     1485


<210> 98
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CD19 monoclonal antibody clone FMC63 
      variable heavy chain"

<400> 98
gaggtgaagc tgcaggagag cggccctggc ctggtggccc ccagccagag cctgagcgtg       60

acctgtaccg tgtccggcgt gtccctgccc gactacggcg tgtcctggat ccggcagccc      120

cctaggaagg gcctggagtg gctgggcgtg atctggggca gcgagaccac ctactacaac      180

agcgccctga agagccggct gaccatcatc aaggacaaca gcaagagcca ggtgttcctg      240

aagatgaaca gcctgcagac cgacgacacc gccatctact actgtgccaa gcactactac      300

tacggcggca gctacgccat ggactactgg ggccagggca ccagcgtgac cgtgtccagc      360


<210> 99
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-CD19 clone FMC63 single chain fragment 
      variable (scFv) with Whitlow linker"

<400> 99
gacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc       60

atcagctgcc gggccagcca ggacatcagc aagtacctga actggtatca gcagaagccc      120

gacggcaccg tcaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggagcag      240

gaggacatcg ccacctactt ttgccagcag ggcaacacac tgccctacac ctttggcggc      300

ggaacaaagc tggagatcac cggcagcacc tccggcagcg gcaagcctgg cagcggcgag      360

ggcagcacca agggcgaggt gaagctgcag gagagcggcc ctggcctggt ggcccccagc      420

cagagcctga gcgtgacctg taccgtgtcc ggcgtgtccc tgcccgacta cggcgtgtcc      480

tggatccggc agccccctag gaagggcctg gagtggctgg gcgtgatctg gggcagcgag      540

accacctact acaacagcgc cctgaagagc cggctgacca tcatcaagga caacagcaag      600

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgt      660

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      720

gtgaccgtgt ccagc                                                       735


<210> 100
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="hM195 VL"

<400> 100
gacattcaga tgacccagtc tccgagctct ctgtccgcat cagtaggaga cagggtcacc       60

atcacatgca gagccagcga aagtgtcgac aattatggca ttagctttat gaactggttc      120

caacagaaac ccgggaaggc tcctaagctt ctgatttacg ctgcatccaa ccaaggctcc      180

ggggtaccct ctcgcttctc aggcagtgga tctgggacag acttcactct caccatttca      240

tctctgcagc ctgatgactt cgcaacctat tactgtcagc aaagtaagga ggttccgtgg      300

acgttcggtc aagggaccaa ggtggagatc aaa                                   333


<210> 101
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="hM195 VH"

<400> 101
caggttcagc tggtgcagtc tggagctgag gtgaagaagc ctgggagctc agtgaaggtt       60

tcctgcaaag cttctggcta caccttcact gactacaaca tgcactgggt gaggcaggct      120

cctggccaag gcctggaatg gattggatat atttatcctt acaatggtgg taccggctac      180

aaccagaagt tcaagagcaa ggccacaatt acagcagacg agagtactaa cacagcctac      240

atggaactct ccagcctgag gtctgaggac actgcagtct attactgcgc aagagggcgc      300

cccgctatgg actactgggg ccaagggact ctggtcactg tctcttca                   348


<210> 102
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="hM195 scFv with linker"

<400> 102
gacattcaga tgacccagtc tccgagctct ctgtccgcat cagtaggaga cagggtcacc       60

atcacatgca gagccagcga aagtgtcgac aattatggca ttagctttat gaactggttc      120

caacagaaac ccgggaaggc tcctaagctt ctgatttacg ctgcatccaa ccaaggctcc      180

ggggtaccct ctcgcttctc aggcagtgga tctgggacag acttcactct caccatttca      240

tctctgcagc ctgatgactt cgcaacctat tactgtcagc aaagtaagga ggttccgtgg      300

acgttcggtc aagggaccaa ggtggagatc aaaggtggcg gtggctcggg cggtggtggg      360

tcgggtggcg gcggatctca ggttcagctg gtgcagtctg gagctgaggt gaagaagcct      420

gggagctcag tgaaggtttc ctgcaaagct tctggctaca ccttcactga ctacaacatg      480

cactgggtga ggcaggctcc tggccaaggc ctggaatgga ttggatatat ttatccttac      540

aatggtggta ccggctacaa ccagaagttc aagagcaagg ccacaattac agcagacgag      600

agtactaaca cagcctacat ggaactctcc agcctgaggt ctgaggacac tgcagtctat      660

tactgcgcaa gagggcgccc cgctatggac tactggggcc aagggactct ggtcactgtc      720

tcttca                                                                 726


<210> 103
<211> 2773
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFR variant III (EGFRvIII)"

<400> 103
atgcgaccct ccgggacggc cggggcagcg ctcctggcgc tgctggctgc gctctgcccg       60

gcgagtcggg ctctggagga aaagaaaggt aattatgtgg tgacagatca cggctcgtgc      120

gtccgagcct gtggggccga cagctatgag atggaggaag acggcgtccg caagtgtaag      180

aagtgcgaag ggccttgccg caaagtgtgt aacggaatag gtattggtga atttaaagac      240

tcactctcca taaatgctac gaatattaaa cacttcaaaa actgcacctc catcagtggc      300

gatctccaca tcctgccggt ggcatttagg ggtgactcct tcacacatac tcctcctctg      360

gatccacagg aactggatat tctgaaaacc gtaaaggaaa tcacagggtt tttgctgatt      420

caggcttggc ctgaaaacag gacggacctc catgcctttg agaacctaga aatcatacgc      480

ggcaggacca agcaacatgg tcagttttct cttgcagtcg tcagcctgaa cataacatcc      540

ttgggattac gctccctcaa ggagataagt gatggagatg tgataatttc aggaaacaaa      600

aatttgtgct atgcaaatac aataaactgg aaaaaactgt ttgggacctc cggtcagaaa      660

accaaaatta taagcaacag aggtgaaaac agctgcaagg ccacaggcca ggtctgccat      720

gccttgtgct cccccgaggg ctgctggggc ccggagccca gggactgcgt ctcttgccgg      780

aatgtcagcc gaggcaggga atgcgtggac aagtgcaacc ttctggaggg tgagccaagg      840

gagtttgtgg agaactctga gtgcatacag tgccacccag agtgcctgcc tcaggccatg      900

aacatcacct gcacaggacg gggaccagac aggagtcatg ggagaaaaca acaccctggt      960

ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc catccaaact gcacctacgg     1020

atgcactggg ccaggtcttg aaggctgtcc aacgaatggg cctaagatcc cgtccatcgc     1080

cactgggatg gtgggggccc tcctcttgct gctggtggtg gccctgggga tcggcctctt     1140

catgcgaagg cgccacatcg ttcggaagcg cacgctgcgg aggctgctgc aggagaggga     1200

gcttgtggag cctcttacac ccagtggaga agctcccaac caagctctct tgaggatctt     1260

gaaggaaact gaattcaaaa agatcaaagt gctgggctcc ggtgcgttcg gcacggtgta     1320

taagggactc tggatcccag aaggtgagaa agttaaaatt cccgtcgcta tcaaggaatt     1380

aagagaagca acatctccga aagccaacaa ggaaatcctc gatgaagcct acgtgatggc     1440

cagcgtggac aacccccacg tgtgccgcct gctgggcatc tgcctcacct ccaccgtgca     1500

gctcatcacg cagctcatgc ccttcggctg cctcctggac tatgtccggg aacacaaaga     1560

caatattggc tcccagtacc tgctcaactg gtgtgtgcag atcgcaaagg gcatgaacta     1620

cttggaggac cgtcgcttgg tgcaccgcga cctggcagcc aggaacgtac tggtgaaaac     1680

accgcagcat gtcaagatca cagattttgg gctggccaaa ctgctgggtg cggaagagaa     1740

agaataccat gcagaaggag gcaaagtgcc tatcaagtgg atggcattgg aatcaatttt     1800

acacagaatc tatacccacc agagtgatgt ctggagctac ggggtgactg tttgggagtt     1860

gatgaccttt ggatccaagc catatgacgg aatccctgcc agcgagatct cctccatcct     1920

ggagaaagga gaacgcctcc ctcagccacc catatgtacc atcgatgtct acatgatcat     1980

ggtcaagtgc tggatgatag acgcagatag tcgcccaaag ttccgtgagt tgatcatcga     2040

attctccaaa atggcccgag acccccagcg ctaccttgtc attcaggggg atgaaagaat     2100

gcatttgcca agtcctacag actccaactt ctaccgtgcc ctgatggatg aagaagacat     2160

ggacgacgtg gtggatgccg acgagtacct catcccacag cagggcttct tcagcagccc     2220

ctccacgtca cggactcccc tcctgagctc tctgagtgca accagcaaca attccaccgt     2280

ggcttgcatt gatagaaatg ggctgcaaag ctgtcccatc aaggaagaca gcttcttgca     2340

gcgatacagc tcagacccca caggcgcctt gactgaggac agcatagacg acaccttcct     2400

cccagtgcct gaatacataa accagtccgt tcccaaaagg cccgctggct ctgtgcagaa     2460

tcctgtctat cacaatcagc ctctgaaccc cgcgcccagc agagacccac actaccagga     2520

cccccacagc actgcagtgg gcaaccccga gtatctcaac actgtccagc ccacctgtgt     2580

caacagcaca ttcgacagcc ctgcccactg ggcccagaaa ggcagccacc aaattagcct     2640

ggacaaccct gactaccagc aggacttctt tcccaaggaa gccaagccaa atggcatctt     2700

taagggctcc acagctgaaa atgcagaata cctaagggtc gcgccacaaa gcagtgaatt     2760

tattggagca tga                                                        2773


<210> 104
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone 139 VH"

<400> 104
gaagtgcagg tgctggaaag cggcggagga ctggtgcagc ctggcggatc tctgagactg       60

agctgtgccg ccagcggctt caccttcagc agctacgcca tgagctgggt gcgccaggcc      120

cctggaaaag gcctggaatg ggtgtccgcc atctctggct ccggcggcag caccaattac      180

gccgatagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cggaagctct      300

gggtggagcg agtattgggg ccagggcaca ctcgtgaccg tgtccagc                   348


<210> 105
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone 139 VL"

<400> 105
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta gagccagcca gggcatccgg aacaacctgg cctggtatca gcagaagccc      120

ggcaaggccc ccaagcggct gatctacgcc gccagcaatc tgcagagcgg cgtgccctct      180

agattcaccg gctctggcag cggcaccgag ttcaccctga tcgtgtctag cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag caccacagct accccctgac atctggcgga      300

ggcaccaagg tggaaatcaa g                                                321


<210> 106
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1 VH"

<400> 106
caagtgaagc tgcagcagtc tggcggaggc ctcgtgaaac ctggcgcctc tctgaagctg       60

agctgcgtga ccagcggctt caccttcaga aagttcggca tgagctgggt gcgccagacc      120

agcgacaagc ggctggaatg ggtggccagc atcagcaccg gcggctacaa cacctactac      180

agcgacaacg tgaagggcag attcaccatc agcagagaga acgccaagaa taccctgtac      240

ctgcagatga gcagcctgaa gtccgaggac accgccctgt actactgcac cagaggctac      300

agcagcacca gctacgccat ggactattgg ggccagggca ccaccgtgac cgtgtctagt      360


<210> 107
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1 VL"

<400> 107
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agcttcaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa g                                                321


<210> 108
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1-1 VH"

<400> 108
caagtgaagc tgcagcagtc tggcggaggc ctcgtgaaac ctggcgcctc tctgaagctg       60

agctgcgtga ccagcggctt caccttcaga aagttcggca tgagctgggt gcgccagacc      120

agcgacaagc ggctggaatg ggtggccagc atcagcaccg gcggctacaa cacctactac      180

agcgacaacg tgaagggcag attcaccatc agcagagaga acgccaagaa taccctgtac      240

ctgcagatga gcagcctgaa gtccgaggac accgccctgt actactgcac cagaggctac      300

agcccctaca gctacgccat ggactattgg ggccagggca ccaccgtgac cgtgtctagt      360


<210> 109
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1-1 VL"

<400> 109
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agctggaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa g                                                321


<210> 110
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-1 VH"

<400> 110
caggtgcagc tgcaggaatc tggcggaggg ctcgtgaagc ctggcggaag cctgaagctg       60

agctgtgccg ccagcggctt caccttcagc aagttcggca tgagctgggt gcgccagacc      120

cccgacaaga gactggaatg ggtggccagc atcagcaccg gcggctacaa tacctactac      180

agcgacaacg tgaagggccg gttcaccatc tcccgggaca acgccaagaa caccctgtac      240

ctgcagatga gcagcctgaa gtccgaggac accgccatgt actactgtgc cagaggctac      300

agcccctaca gctacgccat ggattactgg ggccagggca caatggtcac cgtgtcctct      360


<210> 111
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-1 VL"

<400> 111
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa g                                                321


<210> 112
<211> 360
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-2 VH"

<400> 112
caggtgcagc tgcaggaatc tggcggaggg ctcgtgaagc ctggcggaag cctgaagctg       60

agctgtgccg ccagcggctt caccttcagc aagttcggca tgagctgggt gcgccagacc      120

cccgacaaga gactggaatg ggtggccagc atcagcaccg gcggctacaa caccttctac      180

agcgacaacg tgaagggccg gttcaccatc tcccgggaca acgccaagaa caccctgtac      240

ctgcagatga gcagcctgaa gtccgaggac accgccatgt actactgtgc cagaggctac      300

agcccctaca gcttcgccat ggattactgg ggccagggca caatggtcac cgtgtcctct      360


<210> 113
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-2 VL"

<400> 113
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa g                                                321


<210> 114
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti- EGFRvIII scFv Clone 139"

<400> 114
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta gagccagcca gggcatccgg aacaacctgg cctggtatca gcagaagccc      120

ggcaaggccc ccaagcggct gatctacgcc gccagcaatc tgcagagcgg cgtgccctct      180

agattcaccg gctctggcag cggcaccgag ttcaccctga tcgtgtctag cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag caccacagct accccctgac atctggcgga      300

ggcaccaagg tggaaatcaa gggcagcaca agcggcagcg gaaaacctgg atctggcgag      360

ggctctacca agggcgaagt gcaggtgctg gaaagcggcg gaggactggt gcagcctggc      420

ggatctctga gactgagctg tgccgccagc ggcttcacct tcagcagcta cgccatgagc      480

tgggtgcgcc aggcccctgg aaaaggcctg gaatgggtgt ccgccatctc tggctccggc      540

ggcagcacca attacgccga tagcgtgaag ggccggttca ccatcagccg ggacaacagc      600

aagaacaccc tgtacctgca gatgaacagc ctgagagccg aggacaccgc cgtgtactac      660

tgtgccggaa gctctgggtg gagcgagtat tggggccagg gcacactcgt gaccgtgtcc      720

agc                                                                    723


<210> 115
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-EGFRvIII scFv clone MR1"

<400> 115
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agcttcaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagca gcaccagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagt                                                                 726


<210> 116
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti EGFRvIII scFv clone MR1-1"

<400> 116
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agctggaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagcc cctacagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagt                                                                 726


<210> 117
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-EGFRvIII scFv clone huMR1-1"

<400> 117
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaatacc      540

tactacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagcta cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctct                                                                 726


<210> 118
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="Anti-EGFRvIII scFv clone huMR1-2"

<400> 118
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

ttctacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagctt cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctct                                                                 726


<210> 119
<211> 1410
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (clone 139 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 119
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta gagccagcca gggcatccgg aacaacctgg cctggtatca gcagaagccc      120

ggcaaggccc ccaagcggct gatctacgcc gccagcaatc tgcagagcgg cgtgccctct      180

agattcaccg gctctggcag cggcaccgag ttcaccctga tcgtgtctag cctgcagccc      240

gaggacttcg ccacctacta ctgcctgcag caccacagct accccctgac atctggcgga      300

ggcaccaagg tggaaatcaa gggcagcaca agcggcagcg gaaaacctgg atctggcgag      360

ggctctacca agggcgaagt gcaggtgctg gaaagcggcg gaggactggt gcagcctggc      420

ggatctctga gactgagctg tgccgccagc ggcttcacct tcagcagcta cgccatgagc      480

tgggtgcgcc aggcccctgg aaaaggcctg gaatgggtgt ccgccatctc tggctccggc      540

ggcagcacca attacgccga tagcgtgaag ggccggttca ccatcagccg ggacaacagc      600

aagaacaccc tgtacctgca gatgaacagc ctgagagccg aggacaccgc cgtgtactac      660

tgtgccggaa gctctgggtg gagcgagtat tggggccagg gcacactcgt gaccgtgtcc      720

agcaagccca ccaccacccc tgcccctaga cctccaaccc cagcccctac aatcgccagc      780

cagcccctga gcctgaggcc cgaagcctgt agacctgccg ctggcggagc cgtgcacacc      840

agaggcctgg atttcgcctg cgacatctac atctgggccc ctctggccgg cacctgtggc      900

gtgctgctgc tgagcctggt catcaccctg tactgcaacc accggaataa gagaggccgg      960

aagaaactgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac cacccaggaa     1020

gaggacggct gcagctgccg gttccccgag gaagaggaag gcggctgcga actgcgggtg     1080

aagttcagcc ggagcgccga cgcccctgcc taccagcagg gccagaacca gctgtacaac     1140

gagctgaacc tgggccggag ggaggagtac gacgtgctgg acaagcggag aggccgggac     1200

cctgagatgg gcggcaagcc ccggagaaag aaccctcagg agggcctgta taacgaactg     1260

cagaaagaca agatggccga ggcctacagc gagatcggca tgaagggcga gcggcggagg     1320

ggcaagggcc acgacggcct gtaccagggc ctgagcaccg ccaccaagga tacctacgac     1380

gccctgcaca tgcaggccct gccccccaga                                      1410


<210> 120
<211> 1413
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 120
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agcttcaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagca gcaccagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagtaagc ccaccaccac ccctgcccct agacctccaa ccccagcccc tacaatcgcc      780

agccagcccc tgagcctgag gcccgaagcc tgtagacctg ccgctggcgg agccgtgcac      840

accagaggcc tggatttcgc ctgcgacatc tacatctggg cccctctggc cggcacctgt      900

ggcgtgctgc tgctgagcct ggtcatcacc ctgtactgca accaccggaa taagagaggc      960

cggaagaaac tgctgtacat cttcaagcag cccttcatgc ggcccgtgca gaccacccag     1020

gaagaggacg gctgcagctg ccggttcccc gaggaagagg aaggcggctg cgaactgcgg     1080

gtgaagttca gccggagcgc cgacgcccct gcctaccagc agggccagaa ccagctgtac     1140

aacgagctga acctgggccg gagggaggag tacgacgtgc tggacaagcg gagaggccgg     1200

gaccctgaga tgggcggcaa gccccggaga aagaaccctc aggagggcct gtataacgaa     1260

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggcgg     1320

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggatacctac     1380

gacgccctgc acatgcaggc cctgcccccc aga                                  1413


<210> 121
<211> 1413
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 121
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agctggaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagcc cctacagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagtaagc ccaccaccac ccctgcccct agacctccaa ccccagcccc tacaatcgcc      780

agccagcccc tgagcctgag gcccgaagcc tgtagacctg ccgctggcgg agccgtgcac      840

accagaggcc tggatttcgc ctgcgacatc tacatctggg cccctctggc cggcacctgt      900

ggcgtgctgc tgctgagcct ggtcatcacc ctgtactgca accaccggaa taagagaggc      960

cggaagaaac tgctgtacat cttcaagcag cccttcatgc ggcccgtgca gaccacccag     1020

gaagaggacg gctgcagctg ccggttcccc gaggaagagg aaggcggctg cgaactgcgg     1080

gtgaagttca gccggagcgc cgacgcccct gcctaccagc agggccagaa ccagctgtac     1140

aacgagctga acctgggccg gagggaggag tacgacgtgc tggacaagcg gagaggccgg     1200

gaccctgaga tgggcggcaa gccccggaga aagaaccctc aggagggcct gtataacgaa     1260

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggcgg     1320

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggatacctac     1380

gacgccctgc acatgcaggc cctgcccccc aga                                  1413


<210> 122
<211> 1413
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (humMR1-1 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 122
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaatacc      540

tactacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagcta cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctctaagc ccaccaccac ccctgcccct agacctccaa ccccagcccc tacaatcgcc      780

agccagcccc tgagcctgag gcccgaagcc tgtagacctg ccgctggcgg agccgtgcac      840

accagaggcc tggatttcgc ctgcgacatc tacatctggg cccctctggc cggcacctgt      900

ggcgtgctgc tgctgagcct ggtcatcacc ctgtactgca accaccggaa taagagaggc      960

cggaagaaac tgctgtacat cttcaagcag cccttcatgc ggcccgtgca gaccacccag     1020

gaagaggacg gctgcagctg ccggttcccc gaggaagagg aaggcggctg cgaactgcgg     1080

gtgaagttca gccggagcgc cgacgcccct gcctaccagc agggccagaa ccagctgtac     1140

aacgagctga acctgggccg gagggaggag tacgacgtgc tggacaagcg gagaggccgg     1200

gaccctgaga tgggcggcaa gccccggaga aagaaccctc aggagggcct gtataacgaa     1260

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggcgg     1320

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggatacctac     1380

gacgccctgc acatgcaggc cctgcccccc aga                                  1413


<210> 123
<211> 1413
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (humMR1-2 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 123
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

ttctacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagctt cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctctaagc ccaccaccac ccctgcccct agacctccaa ccccagcccc tacaatcgcc      780

agccagcccc tgagcctgag gcccgaagcc tgtagacctg ccgctggcgg agccgtgcac      840

accagaggcc tggatttcgc ctgcgacatc tacatctggg cccctctggc cggcacctgt      900

ggcgtgctgc tgctgagcct ggtcatcacc ctgtactgca accaccggaa taagagaggc      960

cggaagaaac tgctgtacat cttcaagcag cccttcatgc ggcccgtgca gaccacccag     1020

gaagaggacg gctgcagctg ccggttcccc gaggaagagg aaggcggctg cgaactgcgg     1080

gtgaagttca gccggagcgc cgacgcccct gcctaccagc agggccagaa ccagctgtac     1140

aacgagctga acctgggccg gagggaggag tacgacgtgc tggacaagcg gagaggccgg     1200

gaccctgaga tgggcggcaa gccccggaga aagaaccctc aggagggcct gtataacgaa     1260

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggcgg     1320

aggggcaagg gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggatacctac     1380

gacgccctgc acatgcaggc cctgcccccc aga                                  1413


<210> 124
<211> 1554
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha 2x hinge
      &TM.4-1BB.CD3-zeta)"

<400> 124
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agctggaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagcc cctacagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagtaaac ctactacaac tcctgccccc cggcctccta caccagctcc tactatcgcc      780

tcccagccac tcagtctcag acccgaggct tctaggccag cggccggagg cgcggtccac      840

acccgcgggc tggactttgc atccgataag cccaccacca cccctgcccc tagacctcca      900

accccagccc ctacaatcgc cagccagccc ctgagcctga ggcccgaagc ctgtagacct      960

gccgctggcg gagccgtgca caccagaggc ctggatttcg cctgcgacat ctacatctgg     1020

gcccctctgg ccggcacctg tggcgtgctg ctgctgagcc tggtcatcac cctgtactgc     1080

aaccaccgga ataagagagg ccggaagaaa ctgctgtaca tcttcaagca gcccttcatg     1140

cggcccgtgc agaccaccca ggaagaggac ggctgcagct gccggttccc cgaggaagag     1200

gaaggcggct gcgaactgcg ggtgaagttc agccggagcg ccgacgcccc tgcctaccag     1260

cagggccaga accagctgta caacgagctg aacctgggcc ggagggagga gtacgacgtg     1320

ctggacaagc ggagaggccg ggaccctgag atgggcggca agccccggag aaagaaccct     1380

caggagggcc tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc     1440

ggcatgaagg gcgagcggcg gaggggcaag ggccacgacg gcctgtacca gggcctgagc     1500

accgccacca aggataccta cgacgccctg cacatgcagg ccctgccccc caga           1554


<210> 125
<211> 1695
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha 3x hinge
      &TM.4-1BB.CD3-zeta)"

<400> 125
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agctggaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagcc cctacagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagtaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc tacgattgcc      780

agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg tgccgtccat      840

acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc aaggccccca      900

accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc cagccggcca      960

gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa gcccaccacc     1020

acccctgccc ctagacctcc aaccccagcc cctacaatcg ccagccagcc cctgagcctg     1080

aggcccgaag cctgtagacc tgccgctggc ggagccgtgc acaccagagg cctggatttc     1140

gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct gctgctgagc     1200

ctggtcatca ccctgtactg caaccaccgg aataagagag gccggaagaa actgctgtac     1260

atcttcaagc agcccttcat gcggcccgtg cagaccaccc aggaagagga cggctgcagc     1320

tgccggttcc ccgaggaaga ggaaggcggc tgcgaactgc gggtgaagtt cagccggagc     1380

gccgacgccc ctgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc     1440

cggagggagg agtacgacgt gctggacaag cggagaggcc gggaccctga gatgggcggc     1500

aagccccgga gaaagaaccc tcaggagggc ctgtataacg aactgcagaa agacaagatg     1560

gccgaggcct acagcgagat cggcatgaag ggcgagcggc ggaggggcaa gggccacgac     1620

ggcctgtacc agggcctgag caccgccacc aaggatacct acgacgccct gcacatgcag     1680

gccctgcccc ccaga                                                      1695


<210> 126
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha 4x hinge
      &TM.4-1BB.CD3-zeta)"

<400> 126
gacatcgagc tgacacagag ccctgccagc ctgtctgtgg ccaccggcga gaaagtgacc       60

atccggtgca tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcgagcccc ccaagttcct gatcagcgag ggcaacacac tgcggcctgg cgtgccaagc      180

agattcagca gctctggcac cggcaccgac ttcgtgttca ccatcgagaa caccctgagc      240

gaggacgtgg gcgactacta ctgcctgcag agctggaacg tgcccctgac ctttggcgac      300

ggcaccaagc tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcaag tgaagctgca gcagtctggc ggaggcctcg tgaaacctgg cgcctctctg      420

aagctgagct gcgtgaccag cggcttcacc ttcagaaagt tcggcatgag ctgggtgcgc      480

cagaccagcg acaagcggct ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

tactacagcg acaacgtgaa gggcagattc accatcagca gagagaacgc caagaatacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccctgtacta ctgcaccaga      660

ggctacagcc cctacagcta cgccatggac tattggggcc agggcaccac cgtgaccgtg      720

tctagtaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc tacgattgcc      780

agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg tgccgtccat      840

acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc aaggccccca      900

accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc cagccggcca      960

gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa acctactaca     1020

actcctgccc cccggcctcc tacaccagct cctactatcg cctcccagcc actcagtctc     1080

agacccgagg cttctaggcc agcggccgga ggcgcggtcc acacccgcgg gctggacttt     1140

gcatccgata agcccaccac cacccctgcc cctagacctc caaccccagc ccctacaatc     1200

gccagccagc ccctgagcct gaggcccgaa gcctgtagac ctgccgctgg cggagccgtg     1260

cacaccagag gcctggattt cgcctgcgac atctacatct gggcccctct ggccggcacc     1320

tgtggcgtgc tgctgctgag cctggtcatc accctgtact gcaaccaccg gaataagaga     1380

ggccggaaga aactgctgta catcttcaag cagcccttca tgcggcccgt gcagaccacc     1440

caggaagagg acggctgcag ctgccggttc cccgaggaag aggaaggcgg ctgcgaactg     1500

cgggtgaagt tcagccggag cgccgacgcc cctgcctacc agcagggcca gaaccagctg     1560

tacaacgagc tgaacctggg ccggagggag gagtacgacg tgctggacaa gcggagaggc     1620

cgggaccctg agatgggcgg caagccccgg agaaagaacc ctcaggaggg cctgtataac     1680

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg     1740

cggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggatacc     1800

tacgacgccc tgcacatgca ggccctgccc cccaga                               1836


<210> 127
<211> 1695
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-1 scFv.CD8alpha 3x hinge 
      & TM.4-1BB.CD3-zeta)"

<400> 127
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaatacc      540

tactacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagcta cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctctaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc tacgattgcc      780

agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg tgccgtccat      840

acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc aaggccccca      900

accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc cagccggcca      960

gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa gcccaccacc     1020

acccctgccc ctagacctcc aaccccagcc cctacaatcg ccagccagcc cctgagcctg     1080

aggcccgaag cctgtagacc tgccgctggc ggagccgtgc acaccagagg cctggatttc     1140

gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct gctgctgagc     1200

ctggtcatca ccctgtactg caaccaccgg aataagagag gccggaagaa actgctgtac     1260

atcttcaagc agcccttcat gcggcccgtg cagaccaccc aggaagagga cggctgcagc     1320

tgccggttcc ccgaggaaga ggaaggcggc tgcgaactgc gggtgaagtt cagccggagc     1380

gccgacgccc ctgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc     1440

cggagggagg agtacgacgt gctggacaag cggagaggcc gggaccctga gatgggcggc     1500

aagccccgga gaaagaaccc tcaggagggc ctgtataacg aactgcagaa agacaagatg     1560

gccgaggcct acagcgagat cggcatgaag ggcgagcggc ggaggggcaa gggccacgac     1620

ggcctgtacc agggcctgag caccgccacc aaggatacct acgacgccct gcacatgcag     1680

gccctgcccc ccaga                                                      1695


<210> 128
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-1 scFv.CD8alpha 4x hinge 
      & TM.4-1BB.CD3-zeta)"

<400> 128
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaatacc      540

tactacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagcta cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctctaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc tacgattgcc      780

agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg tgccgtccat      840

acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc aaggccccca      900

accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc cagccggcca      960

gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa acctactaca     1020

actcctgccc cccggcctcc tacaccagct cctactatcg cctcccagcc actcagtctc     1080

agacccgagg cttctaggcc agcggccgga ggcgcggtcc acacccgcgg gctggacttt     1140

gcatccgata agcccaccac cacccctgcc cctagacctc caaccccagc ccctacaatc     1200

gccagccagc ccctgagcct gaggcccgaa gcctgtagac ctgccgctgg cggagccgtg     1260

cacaccagag gcctggattt cgcctgcgac atctacatct gggcccctct ggccggcacc     1320

tgtggcgtgc tgctgctgag cctggtcatc accctgtact gcaaccaccg gaataagaga     1380

ggccggaaga aactgctgta catcttcaag cagcccttca tgcggcccgt gcagaccacc     1440

caggaagagg acggctgcag ctgccggttc cccgaggaag aggaaggcgg ctgcgaactg     1500

cgggtgaagt tcagccggag cgccgacgcc cctgcctacc agcagggcca gaaccagctg     1560

tacaacgagc tgaacctggg ccggagggag gagtacgacg tgctggacaa gcggagaggc     1620

cgggaccctg agatgggcgg caagccccgg agaaagaacc ctcaggaggg cctgtataac     1680

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg     1740

cggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggatacc     1800

tacgacgccc tgcacatgca ggccctgccc cccaga                               1836


<210> 129
<211> 1695
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-2 scFv.CD8alpha 3x hinge 
      & TM.4-1BB.CD3-zeta)"

<400> 129
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

ttctacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagctt cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctctaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc tacgattgcc      780

agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg tgccgtccat      840

acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc aaggccccca      900

accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc cagccggcca      960

gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa gcccaccacc     1020

acccctgccc ctagacctcc aaccccagcc cctacaatcg ccagccagcc cctgagcctg     1080

aggcccgaag cctgtagacc tgccgctggc ggagccgtgc acaccagagg cctggatttc     1140

gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct gctgctgagc     1200

ctggtcatca ccctgtactg caaccaccgg aataagagag gccggaagaa actgctgtac     1260

atcttcaagc agcccttcat gcggcccgtg cagaccaccc aggaagagga cggctgcagc     1320

tgccggttcc ccgaggaaga ggaaggcggc tgcgaactgc gggtgaagtt cagccggagc     1380

gccgacgccc ctgcctacca gcagggccag aaccagctgt acaacgagct gaacctgggc     1440

cggagggagg agtacgacgt gctggacaag cggagaggcc gggaccctga gatgggcggc     1500

aagccccgga gaaagaaccc tcaggagggc ctgtataacg aactgcagaa agacaagatg     1560

gccgaggcct acagcgagat cggcatgaag ggcgagcggc ggaggggcaa gggccacgac     1620

ggcctgtacc agggcctgag caccgccacc aaggatacct acgacgccct gcacatgcag     1680

gccctgcccc ccaga                                                      1695


<210> 130
<211> 1836
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-2 scFv.CD8alpha 4x hinge 
      & TM.4-1BB.CD3-zeta"

<400> 130
gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga cagagtgacc       60

atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca gcagaagccc      120

ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc cctgcagccc      240

gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc tgggggaggc      360

ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg cggaagcctg      420

aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag ctgggtgcgc      480

cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg ctacaacacc      540

ttctacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc caagaacacc      600

ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta ctgtgccaga      660

ggctacagcc cctacagctt cgccatggat tactggggcc agggcacaat ggtcaccgtg      720

tcctctaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc tacgattgcc      780

agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg tgccgtccat      840

acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc aaggccccca      900

accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc cagccggcca      960

gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa acctactaca     1020

actcctgccc cccggcctcc tacaccagct cctactatcg cctcccagcc actcagtctc     1080

agacccgagg cttctaggcc agcggccgga ggcgcggtcc acacccgcgg gctggacttt     1140

gcatccgata agcccaccac cacccctgcc cctagacctc caaccccagc ccctacaatc     1200

gccagccagc ccctgagcct gaggcccgaa gcctgtagac ctgccgctgg cggagccgtg     1260

cacaccagag gcctggattt cgcctgcgac atctacatct gggcccctct ggccggcacc     1320

tgtggcgtgc tgctgctgag cctggtcatc accctgtact gcaaccaccg gaataagaga     1380

ggccggaaga aactgctgta catcttcaag cagcccttca tgcggcccgt gcagaccacc     1440

caggaagagg acggctgcag ctgccggttc cccgaggaag aggaaggcgg ctgcgaactg     1500

cgggtgaagt tcagccggag cgccgacgcc cctgcctacc agcagggcca gaaccagctg     1560

tacaacgagc tgaacctggg ccggagggag gagtacgacg tgctggacaa gcggagaggc     1620

cgggaccctg agatgggcgg caagccccgg agaaagaacc ctcaggaggg cctgtataac     1680

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg     1740

cggaggggca agggccacga cggcctgtac cagggcctga gcaccgccac caaggatacc     1800

tacgacgccc tgcacatgca ggccctgccc cccaga                               1836


<210> 131
<211> 3224
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-64"

<400> 131
gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat       60

gcaaagcatc gagcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt      120

ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa caaaacaaac      180

tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc tatcgaagga      240

tctgcgatcg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga      300

agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact      360

gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata      420

taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagc      480

tgaagcttcg aggggctcgc atctctcctt cacgcgcccg ccgccctacc tgaggccgcc      540

atccacgccg gttgagtcgc gttctgccgc ctcccgcctg tggtgcctcc tgaactgcgt      600

ccgccgtcta ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt      660

ggagcctacc tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct      720

acgtctttgt ttcgttttct gttctgcgcc gttacagatc caagctgtga ccggcgccta      780

cctgagatca ccggcgaagg aggcctatca tgaagatcta tcgattgtac agctagccgc      840

caccatgctg ctgctggtga ccagcctgct gctgtgtgag ctgccccacc ccgcctttct      900

gctgatcccc gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga      960

cagagtgacc atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca     1020

gcagaagccc ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg     1080

cgtgcccagc agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc     1140

cctgcagccc gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac     1200

ctttggcgga ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc     1260

tgggggaggc ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg     1320

cggaagcctg aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag     1380

ctgggtgcgc cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg     1440

ctacaatacc tactacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc     1500

caagaacacc ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta     1560

ctgtgccaga ggctacagcc cctacagcta cgccatggat tactggggcc agggcacaat     1620

ggtcaccgtg tcctctaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc     1680

tacgattgcc agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg     1740

tgccgtccat acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc     1800

aaggccccca accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc     1860

cagccggcca gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa     1920

gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg ccagccagcc     1980

cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc acaccagagg     2040

cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct     2100

gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataagagag gccggaagaa     2160

actgctgtac atcttcaagc agcccttcat gcggcccgtg cagaccaccc aggaagagga     2220

cggctgcagc tgccggttcc ccgaggaaga ggaaggcggc tgcgaactgc gggtgaagtt     2280

cagccggagc gccgacgccc ctgcctacca gcagggccag aaccagctgt acaacgagct     2340

gaacctgggc cggagggagg agtacgacgt gctggacaag cggagaggcc gggaccctga     2400

gatgggcggc aagccccgga gaaagaaccc tcaggagggc ctgtataacg aactgcagaa     2460

agacaagatg gccgaggcct acagcgagat cggcatgaag ggcgagcggc ggaggggcaa     2520

gggccacgac ggcctgtacc agggcctgag caccgccacc aaggatacct acgacgccct     2580

gcacatgcag gccctgcccc ccagatgaga tatcactagt ctcgagtcga tcatgctcat     2640

agtggcaaga gagagccgta cgtgatcagc gggatctgct gtgccttcta gttgccagcc     2700

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     2760

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     2820

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc     2880

tggggatgcg gtgggctcta tgggtaccca ggtgctgaag aattgacccg gttcctcctg     2940

ggccagaaag aagcaggcac atccccttct ctgtgacaca ccctgtccac gcccctggtt     3000

cttagttcca gccccactca taggacactc atagctcagg agggctccgc cttcaatccc     3060

acccgctaaa gtacttggag cggtctctcc ctccctcatc agcccaccaa accaaaccta     3120

gcctccaaga gtgggaagaa attaaagcaa gataggctat taagtgcaga gggagagaaa     3180

atgcctccaa catgtgagga agtaatgaga gaaatcatag aatt                      3224


<210> 132
<211> 3319
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-30"

<400> 132
gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat       60

gcaaagcatc gagcggccgc aataaaatat ctttattttc attacatctg tgtgttggtt      120

ttttgtgtga atcgtaacta acatacgctc tccatcaaaa caaaacgaaa caaaacaaac      180

tagcaaaata ggctgtcccc agtgcaagtg caggtgccag aacatttctc tatcgaagga      240

tctgcgatcg ctccggtgcc cgtcagtggg cagagcgcac atcgcccaca gtccccgaga      300

agttgggggg aggggtcggc aattgaaccg gtgcctagag aaggtggcgc ggggtaaact      360

gggaaagtga tgtcgtgtac tggctccgcc tttttcccga gggtggggga gaaccgtata      420

taagtgcagt agtcgccgtg aacgttcttt ttcgcaacgg gtttgccgcc agaacacagc      480

tgaagcttcg aggggctcgc atctctcctt cacgcgcccg ccgccctacc tgaggccgcc      540

atccacgccg gttgagtcgc gttctgccgc ctcccgcctg tggtgcctcc tgaactgcgt      600

ccgccgtcta ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt      660

ggagcctacc tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct      720

acgtctttgt ttcgttttct gttctgcgcc gttacagatc caagctgtga ccggcgccta      780

cctgagatca ccggcgaagg aggcctatca tgaagatcta tcgattgtac agctagccgc      840

caccatgctg ctgctggtga ccagcctgct gctgtgtgag ctgccccacc ccgcctttct      900

gctgatcccc gacatccaga tgacccagag ccccagcagc ctgtctgcca gcgtgggcga      960

cagagtgacc atcacctgta tgaccagcac cgacatcgac gacgacatga actggtatca     1020

gcagaagccc ggcaagaccc ccaagctgct gatctacgag ggcaacaccc tgaggcctgg     1080

cgtgcccagc agattttctg gcagcggctc cggcaccgac ttcatcttca ccatcagctc     1140

cctgcagccc gaggatatcg ccacctacta ctgcctgcag agctggaacg tgcccctgac     1200

ctttggcgga ggcaccaagg tggaaatcaa gggcggaggc ggatctggcg gcggaggatc     1260

tgggggaggc ggctctcagg tgcagctgca ggaatctggc ggagggctcg tgaagcctgg     1320

cggaagcctg aagctgagct gtgccgccag cggcttcacc ttcagcaagt tcggcatgag     1380

ctgggtgcgc cagacccccg acaagagact ggaatgggtg gccagcatca gcaccggcgg     1440

ctacaatacc tactacagcg acaacgtgaa gggccggttc accatctccc gggacaacgc     1500

caagaacacc ctgtacctgc agatgagcag cctgaagtcc gaggacaccg ccatgtacta     1560

ctgtgccaga ggctacagcc cctacagcta cgccatggat tactggggcc agggcacaat     1620

ggtcaccgtg tcctctaagc ctaccaccac ccccgcacct cgtcctccaa cccctgcacc     1680

tacgattgcc agtcagcctc tttcactgcg gcctgaggcc agcagaccag ctgccggcgg     1740

tgccgtccat acaagaggac tggacttcgc gtccgataaa cctactacca ctccagcccc     1800

aaggccccca accccagcac cgactatcgc atcacagcct ttgtcactgc gtcctgaagc     1860

cagccggcca gctgcagggg gggccgtcca cacaagggga ctcgactttg cgagtgataa     1920

gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg ccagccagcc     1980

cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc acaccagagg     2040

cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct gtggcgtgct     2100

gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataagagag gccggaagaa     2160

actgctgtac atcttcaagc agcccttcat gcggcccgtg cagaccaccc aggaagagga     2220

cggctgcagc tgccggttcc ccgaggaaga ggaaggcggc tgcgaactgc gggtgaagtt     2280

cagccggagc gccgacgccc ctgcctacca gcagggccag aaccagctgt acaacgagct     2340

gaacctgggc cggagggagg agtacgacgt gctggacaag cggagaggcc gggaccctga     2400

gatgggcggc aagccccgga gaaagaaccc tcaggagggc ctgtataacg aactgcagaa     2460

agacaagatg gccgaggcct acagcgagat cggcatgaag ggcgagcggc ggaggggcaa     2520

gggccacgac ggcctgtacc agggcctgag caccgccacc aaggatacct acgacgccct     2580

gcacatgcag gccctgcccc ccagaagggc caagaggagt ggcagcggcg agggcagagg     2640

aagtcttcta acatgcggtg acgtggagga gaatcccggc cctatgaggc tccctgctca     2700

gctcctgggg ctgctaatgc tctgggtccc aggatccagt gggcgcaaag tgtgtaacgg     2760

aataggtatt ggtgaattta aagactcact ctccataaat gctacgaata ttaaacactt     2820

caaaaactgc acctccatca gtggcgatct ccacatcctg ccggtggcat ttaggggtga     2880

ctccttcaca catactcctc ctctggatcc acaggaactg gatattctga aaaccgtaaa     2940

ggaaatcaca gggtttttgc tgattcaggc ttggcctgaa aacaggacgg acctccatgc     3000

ctttgagaac ctagaaatca tacgcggcag gaccaagcaa catggtcagt tttctcttgc     3060

agtcgtcagc ctgaacataa catccttggg attacgctcc ctcaaggaga taagtgatgg     3120

agatgtgata atttcaggaa acaaaaattt gtgctatgca aatacaataa actggaaaaa     3180

actgtttggg acctccggtc agaaaaccaa aattataagc aacagaggtg aaaacagctg     3240

caaggccaca ggccaggtct gccatgcctt gtgctccccc gagggctgct ggggcccgga     3300

gcccagggac tgcgtctct                                                  3319


<210> 133
<211> 4763
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-59"

<400> 133
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gagccccagc agcctgtctg ccagcgtggg cgacagagtg accatcacct      420

gtatgaccag caccgacatc gacgacgaca tgaactggta tcagcagaag cccggcaaga      480

cccccaagct gctgatctac gagggcaaca ccctgaggcc tggcgtgccc agcagatttt      540

ctggcagcgg ctccggcacc gacttcatct tcaccatcag ctccctgcag cccgaggata      600

tcgccaccta ctactgcctg cagagctgga acgtgcccct gacctttggc ggaggcacca      660

aggtggaaat caagggcgga ggcggatctg gcggcggagg atctggggga ggcggctctc      720

aggtgcagct gcaggaatct ggcggagggc tcgtgaagcc tggcggaagc ctgaagctga      780

gctgtgccgc cagcggcttc accttcagca agttcggcat gagctgggtg cgccagaccc      840

ccgacaagag actggaatgg gtggccagca tcagcaccgg cggctacaat acctactaca      900

gcgacaacgt gaagggccgg ttcaccatct cccgggacaa cgccaagaac accctgtacc      960

tgcagatgag cagcctgaag tccgaggaca ccgccatgta ctactgtgcc agaggctaca     1020

gcccctacag ctacgccatg gattactggg gccagggcac aatggtcacc gtgtcctcta     1080

agcctaccac cacccccgca cctcgtcctc caacccctgc acctacgatt gccagtcagc     1140

ctctttcact gcggcctgag gccagcagac cagctgccgg cggtgccgtc catacaagag     1200

gactggactt cgcgtccgat aaacctacta ccactccagc cccaaggccc ccaaccccag     1260

caccgactat cgcatcacag cctttgtcac tgcgtcctga agccagccgg ccagctgcag     1320

ggggggccgt ccacacaagg ggactcgact ttgcgagtga taagcccacc accacccctg     1380

cccctagacc tccaacccca gcccctacaa tcgccagcca gcccctgagc ctgaggcccg     1440

aagcctgtag acctgccgct ggcggagccg tgcacaccag aggcctggat ttcgcctgcg     1500

acatctacat ctgggcccct ctggccggca cctgtggcgt gctgctgctg agcctggtca     1560

tcaccctgta ctgcaaccac cggaataaga gaggccggaa gaaactgctg tacatcttca     1620

agcagccctt catgcggccc gtgcagacca cccaggaaga ggacggctgc agctgccggt     1680

tccccgagga agaggaaggc ggctgcgaac tgcgggtgaa gttcagccgg agcgccgacg     1740

cccctgccta ccagcagggc cagaaccagc tgtacaacga gctgaacctg ggccggaggg     1800

aggagtacga cgtgctggac aagcggagag gccgggaccc tgagatgggc ggcaagcccc     1860

ggagaaagaa ccctcaggag ggcctgtata acgaactgca gaaagacaag atggccgagg     1920

cctacagcga gatcggcatg aagggcgagc ggcggagggg caagggccac gacggcctgt     1980

accagggcct gagcaccgcc accaaggata cctacgacgc cctgcacatg caggccctgc     2040

cccccagaag agctaagagg ggaagcggag agggcagagg aagtctgcta acatgcggtg     2100

acgtcgagga gaatcctgga cctggcccca agaagaaaag gaaggtggcc ccccccaccg     2160

acgtgagcct gggcgacgag ctgcacctgg acggcgagga cgtggccatg gcccacgccg     2220

acgccctgga cgacttcgac ctggacatgc tgggcgacgg cgacagcccc ggccccggct     2280

tcacccccca cgacagcgcc ccctacggcg ccctggacat ggccgacttc gagttcgagc     2340

agatgttcac cgacgccctg ggcatcgacg agtacggcgg cgaattcgag atgcccgtgg     2400

acaggattct ggaggccgaa ctcgccgtgg agcagaaaag cgaccagggc gtggagggcc     2460

ccggcggaac cggcggcagc ggcagcagcc ccaacgaccc cgtgaccaac atctgccagg     2520

ccgccgacaa gcagctgttc accctggtgg agtgggccaa gaggattccc cacttcagca     2580

gcctgcccct ggacgaccag gtgatcctgc tgagggccgg atggaacgag ctgctgatcg     2640

ccagcttcag ccacaggagc atcgacgtga gggacggcat cctgctggcc accggcctgc     2700

acgtccatag gaacagcgcc cacagcgccg gagtgggcgc catcttcgac agggtgctga     2760

ccgagctggt gagcaagatg agggacatga ggatggacaa gaccgagctg ggctgcctga     2820

gggccatcat cctgttcaac cccgaggtga ggggcctgaa aagcgcccag gaggtggagc     2880

tgctgaggga gaaggtgtac gccgccctgg aggagtacac caggaccacc caccccgacg     2940

agcccggcag attcgccaag ctgctgctga ggctgcccag cctgaggagc atcggcctga     3000

agtgcctgga gcacctgttc ttcttcaggc tgatcggcga cgtgcccatc gacaccttcc     3060

tgatggagat gctggagagc cccagcgaca gcagagctaa gaggggaagc ggagagggca     3120

gaggaagtct gctaacatgc ggtgacgtcg aggagaatcc tggacctaag ctgctgagca     3180

gcatcgagca ggcttgcgac atctgcaggc tgaagaagct gaagtgcagc aaggagaagc     3240

ccaagtgcgc caagtgcctg aagaacaact gggagtgcag atacagcccc aagaccaaga     3300

ggagccccct gaccagggcc cacctgaccg aggtggagag caggctggag aggctggagc     3360

agctgttcct gctgatcttc cccagggagg acctggacat gatcctgaag atggacagcc     3420

tgcaagacat caaggccctg ctgaccggcc tgttcgtgca ggacaacgtg aacaaggacg     3480

ccgtgaccga caggctggcc agcgtggaga ccgacatgcc cctgaccctg aggcagcaca     3540

ggatcagcgc caccagcagc agcgaggaga gcagcaacaa gggccagagg cagctgaccg     3600

tgagccccga gtttcccggg atcaggcccg agtgcgtggt gcccgagacc cagtgcgcca     3660

tgaaaaggaa ggagaagaag gcccagaagg agaaggacaa gctgcccgtg agcaccacca     3720

ccgtcgatga ccacatgccc cccatcatgc agtgcgagcc cccccccccc gaggccgcca     3780

ggattcacga ggtcgtgccc aggttcctga gcgacaagct gctggtgacc aacaggcaga     3840

agaacatccc ccagctgacc gccaaccagc agttcctgat cgccaggctg atctggtatc     3900

aggacggcta cgagcagccc agcgacgagg acctgaaaag gatcacccag acctggcagc     3960

aggccgacga cgagaacgag gagagcgaca cccccttcag gcagatcacc gagatgacca     4020

tcctgaccgt gcagctgatc gtggagttcg ccaagggcct gcccggattc gccaagatca     4080

gccagcccga ccagatcacc ctgctgaagg cttgcagcag cgaggtgatg atgctgaggg     4140

tggccaggag gtacgacgcc gccagcgaca gcatcctgtt cgccaacaac caggcttaca     4200

ccagggacaa ctacaggaag gctggcatgg ccgaggtgat cgaggacctc ctgcacttct     4260

gcagatgtat gtacagcatg gccctggaca acatccacta cgccctgctg accgccgtgg     4320

tgatcttcag cgacaggccc ggcctggagc agccccagct ggtggaggag atccagaggt     4380

actacctgaa caccctgagg atctacatcc tgaaccagct gagcggcagc gccaggagca     4440

gcgtgatcta cggcaagatc ctgagcatcc tgagcgagct gaggaccctg ggaatgcaga     4500

acagcaatat gtgtatcagc ctgaagctga agaacaggaa gctgcccccc ttcctggagg     4560

agatttggga cgtggccgac atgagccaca cccagccccc ccccatcctg gagagcccca     4620

ccaacctgtg aaacttgttt attgcagctt ataatggtta caaataaagc aatagcatca     4680

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca     4740

tcaatgtatc ttatcatgtc tgg                                             4763


<210> 134
<211> 4785
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-60"

<400> 134
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gagccccagc agcctgtctg ccagcgtggg cgacagagtg accatcacct      420

gtatgaccag caccgacatc gacgacgaca tgaactggta tcagcagaag cccggcaaga      480

cccccaagct gctgatctac gagggcaaca ccctgaggcc tggcgtgccc agcagatttt      540

ctggcagcgg ctccggcacc gacttcatct tcaccatcag ctccctgcag cccgaggata      600

tcgccaccta ctactgcctg cagagctgga acgtgcccct gacctttggc ggaggcacca      660

aggtggaaat caagggcgga ggcggatctg gcggcggagg atctggggga ggcggctctc      720

aggtgcagct gcaggaatct ggcggagggc tcgtgaagcc tggcggaagc ctgaagctga      780

gctgtgccgc cagcggcttc accttcagca agttcggcat gagctgggtg cgccagaccc      840

ccgacaagag actggaatgg gtggccagca tcagcaccgg cggctacaat acctactaca      900

gcgacaacgt gaagggccgg ttcaccatct cccgggacaa cgccaagaac accctgtacc      960

tgcagatgag cagcctgaag tccgaggaca ccgccatgta ctactgtgcc agaggctaca     1020

gcccctacag ctacgccatg gattactggg gccagggcac aatggtcacc gtgtcctcta     1080

agcctaccac cacccccgca cctcgtcctc caacccctgc acctacgatt gccagtcagc     1140

ctctttcact gcggcctgag gccagcagac cagctgccgg cggtgccgtc catacaagag     1200

gactggactt cgcgtccgat aaacctacta ccactccagc cccaaggccc ccaaccccag     1260

caccgactat cgcatcacag cctttgtcac tgcgtcctga agccagccgg ccagctgcag     1320

ggggggccgt ccacacaagg ggactcgact ttgcgagtga taagcccacc accacccctg     1380

cccctagacc tccaacccca gcccctacaa tcgccagcca gcccctgagc ctgaggcccg     1440

aagcctgtag acctgccgct ggcggagccg tgcacaccag aggcctggat ttcgcctgcg     1500

acatctacat ctgggcccct ctggccggca cctgtggcgt gctgctgctg agcctggtca     1560

tcaccctgta ctgcaaccac cggaataaga gaggccggaa gaaactgctg tacatcttca     1620

agcagccctt catgcggccc gtgcagacca cccaggaaga ggacggctgc agctgccggt     1680

tccccgagga agaggaaggc ggctgcgaac tgcgggtgaa gttcagccgg agcgccgacg     1740

cccctgccta ccagcagggc cagaaccagc tgtacaacga gctgaacctg ggccggaggg     1800

aggagtacga cgtgctggac aagcggagag gccgggaccc tgagatgggc ggcaagcccc     1860

ggagaaagaa ccctcaggag ggcctgtata acgaactgca gaaagacaag atggccgagg     1920

cctacagcga gatcggcatg aagggcgagc ggcggagggg caagggccac gacggcctgt     1980

accagggcct gagcaccgcc accaaggata cctacgacgc cctgcacatg caggccctgc     2040

cccccagaag agctaagagg ggaagcggag agggcagagg aagtctgcta acatgcggtg     2100

acgtcgagga gaatcctgga cctggcccca agaagaaaag gaaggtggcc ccccccaccg     2160

acgtgagcct gggcgacgag ctgcacctgg acggcgagga cgtggccatg gcccacgccg     2220

acgccctgga cgacttcgac ctggacatgc tgggcgacgg cgacagcccc ggccccggct     2280

tcacccccca cgacagcgcc ccctacggcg ccctggacat ggccgacttc gagttcgagc     2340

agatgttcac cgacgccctg ggcatcgacg agtacggcgg cgaattcgag atgcccgtgg     2400

acaggattct ggaggccgaa ctcgccgtgg agcagaaaag cgaccagggc gtggagggcc     2460

ccggcggaac cggcggcagc ggcagcagcc ccaacgaccc cgtgaccaac atctgccagg     2520

ccgccgacaa gcagctgttc accctggtgg agtgggccaa gaggattccc cacttcagca     2580

gcctgcccct ggacgaccag gtgatcctgc tgagggccgg atggaacgag ctgctgatcg     2640

ccagcttcag ccacaggagc atcgacgtga gggacggcat cctgctggcc accggcctgc     2700

acgtccatag gaacagcgcc cacagcgccg gagtgggcgc catcttcgac agggtgctga     2760

ccgagctggt gagcaagatg agggacatga ggatggacaa gaccgagctg ggctgcctga     2820

gggccatcat cctgttcaac cccgaggtga ggggcctgaa aagcgcccag gaggtggagc     2880

tgctgaggga gaaggtgtac gccgccctgg aggagtacac caggaccacc caccccgacg     2940

agcccggcag attcgccaag ctgctgctga ggctgcccag cctgaggagc atcggcctga     3000

agtgcctgga gcacctgttc ttcttcaggc tgatcggcga cgtgcccatc gacaccttcc     3060

tgatggagat gctggagagc cccagcgaca gctgagcatg cactagtttt ataatttctt     3120

cttccagaat ttctgacatt ttataatttc ttcttccaga agactcacaa cctccatatg     3180

gccaccatga agctgctgag cagcatcgag caggcttgcg acatctgcag gctgaagaag     3240

ctgaagtgca gcaaggagaa gcccaagtgc gccaagtgcc tgaagaacaa ctgggagtgc     3300

agatacagcc ccaagaccaa gaggagcccc ctgaccaggg cccacctgac cgaggtggag     3360

agcaggctgg agaggctgga gcagctgttc ctgctgatct tccccaggga ggacctggac     3420

atgatcctga agatggacag cctgcaagac atcaaggccc tgctgaccgg cctgttcgtg     3480

caggacaacg tgaacaagga cgccgtgacc gacaggctgg ccagcgtgga gaccgacatg     3540

cccctgaccc tgaggcagca caggatcagc gccaccagca gcagcgagga gagcagcaac     3600

aagggccaga ggcagctgac cgtgagcccc gagtttcccg ggatcaggcc cgagtgcgtg     3660

gtgcccgaga cccagtgcgc catgaaaagg aaggagaaga aggcccagaa ggagaaggac     3720

aagctgcccg tgagcaccac caccgtcgat gaccacatgc cccccatcat gcagtgcgag     3780

cccccccccc ccgaggccgc caggattcac gaggtcgtgc ccaggttcct gagcgacaag     3840

ctgctggtga ccaacaggca gaagaacatc ccccagctga ccgccaacca gcagttcctg     3900

atcgccaggc tgatctggta tcaggacggc tacgagcagc ccagcgacga ggacctgaaa     3960

aggatcaccc agacctggca gcaggccgac gacgagaacg aggagagcga cacccccttc     4020

aggcagatca ccgagatgac catcctgacc gtgcagctga tcgtggagtt cgccaagggc     4080

ctgcccggat tcgccaagat cagccagccc gaccagatca ccctgctgaa ggcttgcagc     4140

agcgaggtga tgatgctgag ggtggccagg aggtacgacg ccgccagcga cagcatcctg     4200

ttcgccaaca accaggctta caccagggac aactacagga aggctggcat ggccgaggtg     4260

atcgaggacc tcctgcactt ctgcagatgt atgtacagca tggccctgga caacatccac     4320

tacgccctgc tgaccgccgt ggtgatcttc agcgacaggc ccggcctgga gcagccccag     4380

ctggtggagg agatccagag gtactacctg aacaccctga ggatctacat cctgaaccag     4440

ctgagcggca gcgccaggag cagcgtgatc tacggcaaga tcctgagcat cctgagcgag     4500

ctgaggaccc tgggaatgca gaacagcaat atgtgtatca gcctgaagct gaagaacagg     4560

aagctgcccc ccttcctgga ggagatttgg gacgtggccg acatgagcca cacccagccc     4620

ccccccatcc tggagagccc caccaacctg tgaaacttgt ttattgcagc ttataatggt     4680

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4740

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgg                     4785


<210> 135
<211> 2009
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-61"

<400> 135
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaaccc cgggaggtct atataagcag agctcgttta      180

gtgaaccctc attctggaga cggatcccga gccgagtgtt ttgacctcca tagaacagcc      240

gctaaatcca aggtaaggtc agaagagcta gcgccaccat gtgtcaccag cagttggtca      300

tctcttggtt cagcctggtt tttctggcat ctcccctcgt ggccatctgg gaactgaaga      360

aagatgttta tgtcgtagaa ttggattggt atcccgacgc ccctggagaa atggtggtcc      420

tgacatgtga cacccctgaa gaagatggta tcacctggac cttggaccag agcagtgagg      480

tcttaggctc tggcaagacc ctgaccatcc aagtcaaaga gtttggagat gctggccagt      540

acacctgtca caaaggaggc gaggttctaa gccattcgct cctgctgctt cacaaaaagg      600

aagatggaat ttggtccact gacattctga aggaccagaa agaacccaag aataagacct      660

ttctaagatg cgaggccaag aattattctg gacgtttcac ctgctggtgg ctgacgacaa      720

tcagtactga tttgacattc agtgtcaaaa gcagcagagg ctcttctgac ccccaagggg      780

tgacgtgcgg agctgctaca ctcagcgccg agagagtcag aggggacaac aaggagtatg      840

agtactcagt ggagtgccag gaggacagtg cctgcccagc tgctgaggag agtctgccca      900

ttgaggtcat ggtggatgcc gttcacaagc tcaagtatga aaactacacc agcagcttct      960

tcatcaggga catcatcaaa cctgacccac ccaagaactt gcagctgaag cccctgaaga     1020

acagcagaca ggtggaggtc agctgggagt accctgacac ctggagtact ccacattcct     1080

acttctccct gacattctgc gttcaggtcc agggcaagag caagagagaa aagaaagata     1140

gagtcttcac ggacaagacc tcagccacgg tcatctgccg caaaaatgcc agcattagcg     1200

tgcgggccca ggaccgctac tatagctcat cttggagcga atgggcatct gtgccctgct     1260

ccggtggcgg tggcggcgga tctagaaacc tccccgtggc cactccagac ccaggaatgt     1320

tcccatgcct tcaccacagc cagaacctgc tgagggccgt cagcaacatg ctccagaagg     1380

ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat gaagatatca     1440

caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc aagaatgaga     1500

gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg gcctccagaa     1560

agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg aagatgtacc     1620

aggtggagtt caagaccatg aatgcaaagc tgctgatgga ccccaagagg cagatctttc     1680

tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat ttcaacagtg     1740

agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact aaaatcaagc     1800

tctgcatact tcttcatgct ttcagaatca gagcagtgac tattgataga gtgatgagct     1860

atctgaatgc ttcctaaaac ttgtttattg cagcttataa tggttacaaa taaagcaata     1920

gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca     1980

aactcatcaa tgtatcttat catgtctgg                                       2009


<210> 136
<211> 2873
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-62"

<400> 136
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaaccc cgggaggtct atataagcag agctcgttta      180

gtgaaccctc attctggaga cggatcccga gccgagtgtt ttgacctcca tagaacagcc      240

gctaaatcca aggtaaggtc agaagagcta gcgccaccat gtgtcaccag cagttggtca      300

tctcttggtt cagcctggtt tttctggcat ctcccctcgt ggccatctgg gaactgaaga      360

aagatgttta tgtcgtagaa ttggattggt atcccgacgc ccctggagaa atggtggtcc      420

tgacatgtga cacccctgaa gaagatggta tcacctggac cttggaccag agcagtgagg      480

tcttaggctc tggcaagacc ctgaccatcc aagtcaaaga gtttggagat gctggccagt      540

acacctgtca caaaggaggc gaggttctaa gccattcgct cctgctgctt cacaaaaagg      600

aagatggaat ttggtccact gacattctga aggaccagaa agaacccaag aataagacct      660

ttctaagatg cgaggccaag aattattctg gacgtttcac ctgctggtgg ctgacgacaa      720

tcagtactga tttgacattc agtgtcaaaa gcagcagagg ctcttctgac ccccaagggg      780

tgacgtgcgg agctgctaca ctcagcgccg agagagtcag aggggacaac aaggagtatg      840

agtactcagt ggagtgccag gaggacagtg cctgcccagc tgctgaggag agtctgccca      900

ttgaggtcat ggtggatgcc gttcacaagc tcaagtatga aaactacacc agcagcttct      960

tcatcaggga catcatcaaa cctgacccac ccaagaactt gcagctgaag cccctgaaga     1020

acagcagaca ggtggaggtc agctgggagt accctgacac ctggagtact ccacattcct     1080

acttctccct gacattctgc gttcaggtcc agggcaagag caagagagaa aagaaagata     1140

gagtcttcac ggacaagacc tcagccacgg tcatctgccg caaaaatgcc agcattagcg     1200

tgcgggccca ggaccgctac tatagctcat cttggagcga atgggcatct gtgccctgct     1260

ccggtggcgg tggcggcgga tctagaaacc tccccgtggc cactccagac ccaggaatgt     1320

tcccatgcct tcaccacagc cagaacctgc tgagggccgt cagcaacatg ctccagaagg     1380

ccagacaaac tctagaattt tacccttgca cttctgaaga gattgatcat gaagatatca     1440

caaaagataa aaccagcaca gtggaggcct gtttaccatt ggaattaacc aagaatgaga     1500

gttgcctaaa ttccagagag acctctttca taactaatgg gagttgcctg gcctccagaa     1560

agacctcttt tatgatggcc ctgtgcctta gtagtattta tgaagacttg aagatgtacc     1620

aggtggagtt caagaccatg aatgcaaagc tgctgatgga ccccaagagg cagatctttc     1680

tagatcaaaa catgctggca gttattgatg agctgatgca ggccctgaat ttcaacagtg     1740

agactgtgcc acaaaaatcc tcccttgaag aaccggattt ttataaaact aaaatcaagc     1800

tctgcatact tcttcatgct ttcagaatca gagcagtgac tattgataga gtgatgagct     1860

atctgaatgc ttccagagct aagaggggaa gcggagaggg cagaggaagt ctgctaacat     1920

gcggtgacgt cgaggagaat cctggaccta ggctccctgc tcagctcctg gggctgctaa     1980

tgctctgggt cccaggatcc agtgggcgca aagtgtgtaa cggaataggt attggtgaat     2040

ttaaagactc actctccata aatgctacga atattaaaca cttcaaaaac tgcacctcca     2100

tcagtggcga tctccacatc ctgccggtgg catttagggg tgactccttc acacatactc     2160

ctcctctgga tccacaggaa ctggatattc tgaaaaccgt aaaggaaatc acagggtttt     2220

tgctgattca ggcttggcct gaaaacagga cggacctcca tgcctttgag aacctagaaa     2280

tcatacgcgg caggaccaag caacatggtc agttttctct tgcagtcgtc agcctgaaca     2340

taacatcctt gggattacgc tccctcaagg agataagtga tggagatgtg ataatttcag     2400

gaaacaaaaa tttgtgctat gcaaatacaa taaactggaa aaaactgttt gggacctccg     2460

gtcagaaaac caaaattata agcaacagag gtgaaaacag ctgcaaggcc acaggccagg     2520

tctgccatgc cttgtgctcc cccgagggct gctggggccc ggagcccagg gactgcgtct     2580

ctggtggcgg tggctcgggc ggtggtgggt cgggtggcgg cggatctggt ggcggtggct     2640

cgttttgggt gctggtggtg gttggtggag tcctggcttg ctatagcttg ctagtaacag     2700

tggcctttat tattttctgg gtgaggagta agaggagcta aaacttgttt attgcagctt     2760

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     2820

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgg            2873


<210> 137
<211> 3532
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FLC-2B12/13-2"

<400> 137
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaaccc cgggaggtct atataagcag agctcgttta      180

gtgaaccctc attctggaga cggatcccga gccgagtgtt ttgacctcca tagaacagcc      240

gctaaatcca aggtaaggtc agaagagcta gcgccaccat ggattggacc tggattctgt      300

ttctggtggc cgctgccaca agagtgcaca gcaactgggt gaatgtgatc agcgacctga      360

agaagatcga ggatctgatc cagagcatgc acattgatgc caccctgtac acagaatctg      420

atgtgcaccc tagctgtaaa gtgaccgcca tgaagtgttt tctgctggag ctgcaggtga      480

tttctctgga aagcggagat gcctctatcc acgacacagt ggagaatctg atcatcctgg      540

ccaacaatag cctgagcagc aatggcaatg tgacagagtc tggctgtaag gagtgtgagg      600

agctggagga gaagaacatc aaggagtttc tgcagagctt tgtgcacatc gtgcagatgt      660

tcatcaatac aagctctggc ggaggatctg gaggaggcgg atctggagga ggaggcagtg      720

gaggcggagg atctggcgga ggatctctgc agattacatg ccctcctcca atgtctgtgg      780

agcacgccga tatttgggtg aagtcctaca gcctgtacag cagagagaga tacatctgca      840

acagcggctt taagagaaag gccggcacct cttctctgac agagtgcgtg ctgaataagg      900

ccacaaatgt ggcccactgg acaacaccta gcctgaagtg cattagagat cctgccctgg      960

tccaccagag gcctgcccct ccatctacag tgacaacagc cggagtgaca cctcagcctg     1020

aatctctgag cccttctgga aaagaacctg ccgccagctc tcctagctct aataataccg     1080

ccgccacaac agccgccatt gtgcctggat ctcagctgat gcctagcaag tctcctagca     1140

caggcacaac agagatcagc agccacgaat cttctcacgg aacaccttct cagaccaccg     1200

ccaagaattg ggagctgaca gcctctgcct ctcaccagcc tccaggagtg tatcctcagg     1260

gccactctga tacaacagtg gccatcagca catctacagt gctgctgtgt ggactgtctg     1320

ccgtgtctct gctggcctgt tacctgaagt ctagacagac acctcctctg gcctctgtgg     1380

agatggaggc catggaagcc ctgcctgtga catggggaac aagcagcaga gatgaggacc     1440

tggagaattg ttctcaccac ctgtgaaact tgtttattgc agcttataat ggttacaaat     1500

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     1560

gtttgtccaa actcatcaat gtatcttatc atgtctggga gcgtgcgtga ggctccggtg     1620

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggagggggtc     1680

ggcgattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg     1740

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc     1800

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac agcagccgct aaatccaagg     1860

taaggtcaga agagctagcg ccaccatgaa gctgctgagc agcatcgagc aggcttgcga     1920

catctgcagg ctgaagaagc tgaagtgcag caaggagaag cccaagtgcg ccaagtgcct     1980

gaagaacaac tgggagtgca gatacagccc caagaccaag aggagccccc tgaccagggc     2040

ccacctgacc gaggtggaga gcaggctgga gaggctggag cagctgttcc tgctgatctt     2100

ccccagggag gacctggaca tgatcctgaa gatggacagc ctgcaagaca tcaaggccct     2160

gctgaccggc ctgttcgtgc aggacaacgt gaacaaggac gccgtgaccg acaggctggc     2220

cagcgtggag accgacatgc ccctgaccct gaggcagcac aggatcagcg ccaccagcag     2280

cagcgaggag agcagcaaca agggccagag gcagctgacc gtgagccccg agtttcccgg     2340

gatcaggccc gagtgcgtgg tgcccgagac ccagtgcgcc atgaaaagga aggagaagaa     2400

ggcccagaag gagaaggaca agctgcccgt gagcaccacc accgtcgatg accacatgcc     2460

ccccatcatg cagtgcgagc cccccccccc cgaggccgcc aggattcacg aggtcgtgcc     2520

caggttcctg agcgacaagc tgctggtgac caacaggcag aagaacatcc cccagctgac     2580

cgccaaccag cagttcctga tcgccaggct gatctggtat caggacggct acgagcagcc     2640

cagcgacgag gacctgaaaa ggatcaccca gacctggcag caggccgacg acgagaacga     2700

ggagagcgac acccccttca ggcagatcac cgagatgacc atcctgaccg tgcagctgat     2760

cgtggagttc gccaagggcc tgcccggatt cgccaagatc agccagcccg accagatcac     2820

cctgctgaag gcttgcagca gcgaggtgat gatgctgagg gtggccagga ggtacgacgc     2880

cgccagcgac agcatcctgt tcgccaacaa ccaggcttac accagggaca actacaggaa     2940

ggctggcatg gccgaggtga tcgaggacct cctgcacttc tgcagatgta tgtacagcat     3000

ggccctggac aacatccact acgccctgct gaccgccgtg gtgatcttca gcgacaggcc     3060

cggcctggag cagccccagc tggtggagga gatccagagg tactacctga acaccctgag     3120

gatctacatc ctgaaccagc tgagcggcag cgccaggagc agcgtgatct acggcaagat     3180

cctgagcatc ctgagcgagc tgaggaccct gggaatgcag aacagcaata tgtgtatcag     3240

cctgaagctg aagaacagga agctgccccc cttcctggag gagatttggg acgtggccga     3300

catgagccac acccagcccc cccccatcct ggagagcccc accaacctgt gatgatgggt     3360

ggcatccctg tgacccctcc ccagtgcctc tcctggccct ggaagttgcc actccagtgc     3420

ccaccagcct tgtcctaata aaattaagtt gcatcatttt gtctgactag gtgtccttct     3480

ataatattat ggggtggagg ggggtggtat ggagcaaggg gcaagttggg aa             3532


<210> 138
<211> 4423
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-02"

<400> 138
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaaccc cgggaggtct atataagcag agctcgttta      180

gtgaaccctc attctggaga cggatcccga gccgagtgtt ttgacctcca tagaacagcc      240

gctaaatcca aggtaaggtc agaagagcta gcgccaccat ggattggacc tggattctgt      300

ttctggtggc cgctgccaca agagtgcaca gcaactgggt gaatgtgatc agcgacctga      360

agaagatcga ggatctgatc cagagcatgc acattgatgc caccctgtac acagaatctg      420

atgtgcaccc tagctgtaaa gtgaccgcca tgaagtgttt tctgctggag ctgcaggtga      480

tttctctgga aagcggagat gcctctatcc acgacacagt ggagaatctg atcatcctgg      540

ccaacaatag cctgagcagc aatggcaatg tgacagagtc tggctgtaag gagtgtgagg      600

agctggagga gaagaacatc aaggagtttc tgcagagctt tgtgcacatc gtgcagatgt      660

tcatcaatac aagctctggc ggaggatctg gaggaggcgg atctggagga ggaggcagtg      720

gaggcggagg atctggcgga ggatctctgc agattacatg ccctcctcca atgtctgtgg      780

agcacgccga tatttgggtg aagtcctaca gcctgtacag cagagagaga tacatctgca      840

acagcggctt taagagaaag gccggcacct cttctctgac agagtgcgtg ctgaataagg      900

ccacaaatgt ggcccactgg acaacaccta gcctgaagtg cattagagat cctgccctgg      960

tccaccagag gcctgcccct ccatctacag tgacaacagc cggagtgaca cctcagcctg     1020

aatctctgag cccttctgga aaagaacctg ccgccagctc tcctagctct aataataccg     1080

ccgccacaac agccgccatt gtgcctggat ctcagctgat gcctagcaag tctcctagca     1140

caggcacaac agagatcagc agccacgaat cttctcacgg aacaccttct cagaccaccg     1200

ccaagaattg ggagctgaca gcctctgcct ctcaccagcc tccaggagtg tatcctcagg     1260

gccactctga tacaacagtg gccatcagca catctacagt gctgctgtgt ggactgtctg     1320

ccgtgtctct gctggcctgt tacctgaagt ctagacagac acctcctctg gcctctgtgg     1380

agatggaggc catggaagcc ctgcctgtga catggggaac aagcagcaga gatgaggacc     1440

tggagaattg ttctcaccac ctgtgaaact tgtttattgc agcttataat ggttacaaat     1500

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     1560

gtttgtccaa actcatcaat gtatcttatc atgtctggga gcgtgcgtga ggctccggtg     1620

cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg ggagggggtc     1680

ggcgattgaa ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg     1740

tactggctcc gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc     1800

gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac agcagccgct aaatccaagg     1860

taaggtcaga agagctagcg ccaccatgct gctgctggtg accagcctgc tgctgtgtga     1920

gctgccccac cccgcctttc tgctgatccc cgacatccag atgacccaga ccacctccag     1980

cctgagcgcc agcctgggcg accgggtgac catcagctgc cgggccagcc aggacatcag     2040

caagtacctg aactggtatc agcagaagcc cgacggcacc gtcaagctgc tgatctacca     2100

caccagccgg ctgcacagcg gcgtgcccag ccggtttagc ggcagcggct ccggcaccga     2160

ctacagcctg accatctcca acctggagca ggaggacatc gccacctact tttgccagca     2220

gggcaacaca ctgccctaca cctttggcgg cggaacaaag ctggagatca ccggcagcac     2280

ctccggcagc ggcaagcctg gcagcggcga gggcagcacc aagggcgagg tgaagctgca     2340

ggagagcggc cctggcctgg tggcccccag ccagagcctg agcgtgacct gtaccgtgtc     2400

cggcgtgtcc ctgcccgact acggcgtgtc ctggatccgg cagcccccta ggaagggcct     2460

ggagtggctg ggcgtgatct ggggcagcga gaccacctac tacaacagcg ccctgaagag     2520

ccggctgacc atcatcaagg acaacagcaa gagccaggtg ttcctgaaga tgaacagcct     2580

gcagaccgac gacaccgcca tctactactg tgccaagcac tactactacg gcggcagcta     2640

cgccatggac tactggggcc agggcaccag cgtgaccgtg tccagcaagc ccaccaccac     2700

ccctgcccct agacctccaa ccccagcccc tacaatcgcc agccagcccc tgagcctgag     2760

gcccgaagcc tgtagacctg ccgctggcgg agccgtgcac accagaggcc tggatttcgc     2820

ctgcgacatc tacatctggg cccctctggc cggcacctgt ggcgtgctgc tgctgagcct     2880

ggtcatcacc ctgtactgca accaccggaa taggagcaag cggagcagag gcggccacag     2940

cgactacatg aacatgaccc cccggaggcc tggccccacc cggaagcact accagcccta     3000

cgcccctccc agggacttcg ccgcctaccg gagccgggtg aagttcagcc ggagcgccga     3060

cgcccctgcc taccagcagg gccagaacca gctgtacaac gagctgaacc tgggccggag     3120

ggaggagtac gacgtgctgg acaagcggag aggccgggac cctgagatgg gcggcaagcc     3180

ccggagaaag aaccctcagg agggcctgta taacgaactg cagaaagaca agatggccga     3240

ggcctacagc gagatcggca tgaagggcga gcggcggagg ggcaagggcc acgacggcct     3300

gtaccagggc ctgagcaccg ccaccaagga tacctacgac gccctgcaca tgcaggccct     3360

gccccccaga agggccaaga ggagtggcag cggcgagggc agaggaagtc ttctaacatg     3420

cggtgacgtg gaggagaatc ccggccctat gaggctccct gctcagctcc tggggctgct     3480

aatgctctgg gtcccaggat ccagtgggcg caaagtgtgt aacggaatag gtattggtga     3540

atttaaagac tcactctcca taaatgctac gaatattaaa cacttcaaaa actgcacctc     3600

catcagtggc gatctccaca tcctgccggt ggcatttagg ggtgactcct tcacacatac     3660

tcctcctctg gatccacagg aactggatat tctgaaaacc gtaaaggaaa tcacagggtt     3720

tttgctgatt caggcttggc ctgaaaacag gacggacctc catgcctttg agaacctaga     3780

aatcatacgc ggcaggacca agcaacatgg tcagttttct cttgcagtcg tcagcctgaa     3840

cataacatcc ttgggattac gctccctcaa ggagataagt gatggagatg tgataatttc     3900

aggaaacaaa aatttgtgct atgcaaatac aataaactgg aaaaaactgt ttgggacctc     3960

cggtcagaaa accaaaatta taagcaacag aggtgaaaac agctgcaagg ccacaggcca     4020

ggtctgccat gccttgtgct cccccgaggg ctgctggggc ccggagccca gggactgcgt     4080

ctctggtggc ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg gtggcggtgg     4140

ctcgttttgg gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac     4200

agtggccttt attattttct gggtgaggag taagaggagc taatgatggg tggcatccct     4260

gtgacccctc cccagtgcct ctcctggccc tggaagttgc cactccagtg cccaccagcc     4320

ttgtcctaat aaaattaagt tgcatcattt tgtctgacta ggtgtccttc tataatatta     4380

tggggtggag gggggtggta tggagcaagg ggcaagttgg gaa                       4423


<210> 139
<211> 4423
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-02(h)"

<400> 139
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gaccacctcc agcctgagcg ccagcctggg cgaccgggtg accatcagct      420

gccgggccag ccaggacatc agcaagtacc tgaactggta tcagcagaag cccgacggca      480

ccgtcaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc agccggttta      540

gcggcagcgg ctccggcacc gactacagcc tgaccatctc caacctggag caggaggaca      600

tcgccaccta cttttgccag cagggcaaca cactgcccta cacctttggc ggcggaacaa      660

agctggagat caccggcagc acctccggca gcggcaagcc tggcagcggc gagggcagca      720

ccaagggcga ggtgaagctg caggagagcg gccctggcct ggtggccccc agccagagcc      780

tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcccga ctacggcgtg tcctggatcc      840

ggcagccccc taggaagggc ctggagtggc tgggcgtgat ctggggcagc gagaccacct      900

actacaacag cgccctgaag agccggctga ccatcatcaa ggacaacagc aagagccagg      960

tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac tgtgccaagc     1020

actactacta cggcggcagc tacgccatgg actactgggg ccagggcacc agcgtgaccg     1080

tgtccagcaa gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg     1140

ccagccagcc cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc     1200

acaccagagg cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct     1260

gtggcgtgct gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataggagca     1320

agcggagcag aggcggccac agcgactaca tgaacatgac cccccggagg cctggcccca     1380

cccggaagca ctaccagccc tacgcccctc ccagggactt cgccgcctac cggagccggg     1440

tgaagttcag ccggagcgcc gacgcccctg cctaccagca gggccagaac cagctgtaca     1500

acgagctgaa cctgggccgg agggaggagt acgacgtgct ggacaagcgg agaggccggg     1560

accctgagat gggcggcaag ccccggagaa agaaccctca ggagggcctg tataacgaac     1620

tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc gagcggcgga     1680

ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag gatacctacg     1740

acgccctgca catgcaggcc ctgcccccca gaagggccaa gaggagtggc agcggcgagg     1800

gcagaggaag tcttctaaca tgcggtgacg tggaggagaa tcccggccct atgaggctcc     1860

ctgctcagct cctggggctg ctaatgctct gggtcccagg atccagtggg cgcaaagtgt     1920

gtaacggaat aggtattggt gaatttaaag actcactctc cataaatgct acgaatatta     1980

aacacttcaa aaactgcacc tccatcagtg gcgatctcca catcctgccg gtggcattta     2040

ggggtgactc cttcacacat actcctcctc tggatccaca ggaactggat attctgaaaa     2100

ccgtaaagga aatcacaggg tttttgctga ttcaggcttg gcctgaaaac aggacggacc     2160

tccatgcctt tgagaaccta gaaatcatac gcggcaggac caagcaacat ggtcagtttt     2220

ctcttgcagt cgtcagcctg aacataacat ccttgggatt acgctccctc aaggagataa     2280

gtgatggaga tgtgataatt tcaggaaaca aaaatttgtg ctatgcaaat acaataaact     2340

ggaaaaaact gtttgggacc tccggtcaga aaaccaaaat tataagcaac agaggtgaaa     2400

acagctgcaa ggccacaggc caggtctgcc atgccttgtg ctcccccgag ggctgctggg     2460

gcccggagcc cagggactgc gtctctggtg gcggtggctc gggcggtggt gggtcgggtg     2520

gcggcggatc tggtggcggt ggctcgtttt gggtgctggt ggtggttggt ggagtcctgg     2580

cttgctatag cttgctagta acagtggcct ttattatttt ctgggtgagg agtaagagga     2640

gctaatgatg ggtggcatcc ctgtgacccc tccccagtgc ctctcctggc cctggaagtt     2700

gccactccag tgcccaccag ccttgtccta ataaaattaa gttgcatcat tttgtctgac     2760

taggtgtcct tctataatat tatggggtgg aggggggtgg tatggagcaa ggggcaagtt     2820

gggaaattgt tcggagcagt gcggcgcgtt tagcggagta ctgtcctccg atattaatcg     2880

gggcagacta ttccggggtt taccggcgca ctctcgcccg aacttcaccg gcggtctttc     2940

gtccgtgctt tatcggggcg gatcactccg aaccccggga ggtctatata agcagagctc     3000

gtttagtgaa ccctcattct ggagacggat cccgagccga gtgttttgac ctccatagaa     3060

cagccgctaa atccaaggta aggtcagaag agctagcgcc accatggatt ggacctggat     3120

tctgtttctg gtggccgctg ccacaagagt gcacagcaac tgggtgaatg tgatcagcga     3180

cctgaagaag atcgaggatc tgatccagag catgcacatt gatgccaccc tgtacacaga     3240

atctgatgtg caccctagct gtaaagtgac cgccatgaag tgttttctgc tggagctgca     3300

ggtgatttct ctggaaagcg gagatgcctc tatccacgac acagtggaga atctgatcat     3360

cctggccaac aatagcctga gcagcaatgg caatgtgaca gagtctggct gtaaggagtg     3420

tgaggagctg gaggagaaga acatcaagga gtttctgcag agctttgtgc acatcgtgca     3480

gatgttcatc aatacaagct ctggcggagg atctggagga ggcggatctg gaggaggagg     3540

cagtggaggc ggaggatctg gcggaggatc tctgcagatt acatgccctc ctccaatgtc     3600

tgtggagcac gccgatattt gggtgaagtc ctacagcctg tacagcagag agagatacat     3660

ctgcaacagc ggctttaaga gaaaggccgg cacctcttct ctgacagagt gcgtgctgaa     3720

taaggccaca aatgtggccc actggacaac acctagcctg aagtgcatta gagatcctgc     3780

cctggtccac cagaggcctg cccctccatc tacagtgaca acagccggag tgacacctca     3840

gcctgaatct ctgagccctt ctggaaaaga acctgccgcc agctctccta gctctaataa     3900

taccgccgcc acaacagccg ccattgtgcc tggatctcag ctgatgccta gcaagtctcc     3960

tagcacaggc acaacagaga tcagcagcca cgaatcttct cacggaacac cttctcagac     4020

caccgccaag aattgggagc tgacagcctc tgcctctcac cagcctccag gagtgtatcc     4080

tcagggccac tctgatacaa cagtggccat cagcacatct acagtgctgc tgtgtggact     4140

gtctgccgtg tctctgctgg cctgttacct gaagtctaga cagacacctc ctctggcctc     4200

tgtggagatg gaggccatgg aagccctgcc tgtgacatgg ggaacaagca gcagagatga     4260

ggacctggag aattgttctc accacctgtg aaacttgttt attgcagctt ataatggtta     4320

caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac tgcattctag     4380

ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tgg                       4423


<210> 140
<211> 4487
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FLC-2B8-1"

<400> 140
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gaccacctcc agcctgagcg ccagcctggg cgaccgggtg accatcagct      420

gccgggccag ccaggacatc agcaagtacc tgaactggta tcagcagaag cccgacggca      480

ccgtcaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc agccggttta      540

gcggcagcgg ctccggcacc gactacagcc tgaccatctc caacctggag caggaggaca      600

tcgccaccta cttttgccag cagggcaaca cactgcccta cacctttggc ggcggaacaa      660

agctggagat caccggcagc acctccggca gcggcaagcc tggcagcggc gagggcagca      720

ccaagggcga ggtgaagctg caggagagcg gccctggcct ggtggccccc agccagagcc      780

tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcccga ctacggcgtg tcctggatcc      840

ggcagccccc taggaagggc ctggagtggc tgggcgtgat ctggggcagc gagaccacct      900

actacaacag cgccctgaag agccggctga ccatcatcaa ggacaacagc aagagccagg      960

tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac tgtgccaagc     1020

actactacta cggcggcagc tacgccatgg actactgggg ccagggcacc agcgtgaccg     1080

tgtccagcaa gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg     1140

ccagccagcc cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc     1200

acaccagagg cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct     1260

gtggcgtgct gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataggagca     1320

agcggagcag aggcggccac agcgactaca tgaacatgac cccccggagg cctggcccca     1380

cccggaagca ctaccagccc tacgcccctc ccagggactt cgccgcctac cggagccggg     1440

tgaagttcag ccggagcgcc gacgcccctg cctaccagca gggccagaac cagctgtaca     1500

acgagctgaa cctgggccgg agggaggagt acgacgtgct ggacaagcgg agaggccggg     1560

accctgagat gggcggcaag ccccggagaa agaaccctca ggagggcctg tataacgaac     1620

tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc gagcggcgga     1680

ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag gatacctacg     1740

acgccctgca catgcaggcc ctgcccccca gaagagctaa gaggggaagc ggagagggca     1800

gaggaagtct gctaacatgc ggtgacgtcg aggagaatcc tggacctggc cccaagaaga     1860

aaaggaaggt ggcccccccc accgacgtga gcctgggcga cgagctgcac ctggacggcg     1920

aggacgtggc catggcccac gccgacgccc tggacgactt cgacctggac atgctgggcg     1980

acggcgacag ccccggcccc ggcttcaccc cccacgacag cgccccctac ggcgccctgg     2040

acatggccga cttcgagttc gagcagatgt tcaccgacgc cctgggcatc gacgagtacg     2100

gcggcgaatt cgagatgccc gtggacagga ttctggaggc cgaactcgcc gtggagcaga     2160

aaagcgacca gggcgtggag ggccccggcg gaaccggcgg cagcggcagc agccccaacg     2220

accccgtgac caacatctgc caggccgccg acaagcagct gttcaccctg gtggagtggg     2280

ccaagaggat tccccacttc agcagcctgc ccctggacga ccaggtgatc ctgctgaggg     2340

ccggatggaa cgagctgctg atcgccagct tcagccacag gagcatcgac gtgagggacg     2400

gcatcctgct ggccaccggc ctgcacgtcc ataggaacag cgcccacagc gccggagtgg     2460

gcgccatctt cgacagggtg ctgaccgagc tggtgagcaa gatgagggac atgaggatgg     2520

acaagaccga gctgggctgc ctgagggcca tcatcctgtt caaccccgag gtgaggggcc     2580

tgaaaagcgc ccaggaggtg gagctgctga gggagaaggt gtacgccgcc ctggaggagt     2640

acaccaggac cacccacccc gacgagcccg gcagattcgc caagctgctg ctgaggctgc     2700

ccagcctgag gagcatcggc ctgaagtgcc tggagcacct gttcttcttc aggctgatcg     2760

gcgacgtgcc catcgacacc ttcctgatgg agatgctgga gagccccagc gacagcagag     2820

ctaagagggg aagcggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga     2880

atcctggacc taagctgctg agcagcatcg agcaggcttg cgacatctgc aggctgaaga     2940

agctgaagtg cagcaaggag aagcccaagt gcgccaagtg cctgaagaac aactgggagt     3000

gcagatacag ccccaagacc aagaggagcc ccctgaccag ggcccacctg accgaggtgg     3060

agagcaggct ggagaggctg gagcagctgt tcctgctgat cttccccagg gaggacctgg     3120

acatgatcct gaagatggac agcctgcaag acatcaaggc cctgctgacc ggcctgttcg     3180

tgcaggacaa cgtgaacaag gacgccgtga ccgacaggct ggccagcgtg gagaccgaca     3240

tgcccctgac cctgaggcag cacaggatca gcgccaccag cagcagcgag gagagcagca     3300

acaagggcca gaggcagctg accgtgagcc ccgagtttcc cgggatcagg cccgagtgcg     3360

tggtgcccga gacccagtgc gccatgaaaa ggaaggagaa gaaggcccag aaggagaagg     3420

acaagctgcc cgtgagcacc accaccgtcg atgaccacat gccccccatc atgcagtgcg     3480

agcccccccc ccccgaggcc gccaggattc acgaggtcgt gcccaggttc ctgagcgaca     3540

agctgctggt gaccaacagg cagaagaaca tcccccagct gaccgccaac cagcagttcc     3600

tgatcgccag gctgatctgg tatcaggacg gctacgagca gcccagcgac gaggacctga     3660

aaaggatcac ccagacctgg cagcaggccg acgacgagaa cgaggagagc gacaccccct     3720

tcaggcagat caccgagatg accatcctga ccgtgcagct gatcgtggag ttcgccaagg     3780

gcctgcccgg attcgccaag atcagccagc ccgaccagat caccctgctg aaggcttgca     3840

gcagcgaggt gatgatgctg agggtggcca ggaggtacga cgccgccagc gacagcatcc     3900

tgttcgccaa caaccaggct tacaccaggg acaactacag gaaggctggc atggccgagg     3960

tgatcgagga cctcctgcac ttctgcagat gtatgtacag catggccctg gacaacatcc     4020

actacgccct gctgaccgcc gtggtgatct tcagcgacag gcccggcctg gagcagcccc     4080

agctggtgga ggagatccag aggtactacc tgaacaccct gaggatctac atcctgaacc     4140

agctgagcgg cagcgccagg agcagcgtga tctacggcaa gatcctgagc atcctgagcg     4200

agctgaggac cctgggaatg cagaacagca atatgtgtat cagcctgaag ctgaagaaca     4260

ggaagctgcc ccccttcctg gaggagattt gggacgtggc cgacatgagc cacacccagc     4320

ccccccccat cctggagagc cccaccaacc tgtgaaactt gtttattgca gcttataatg     4380

gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt     4440

ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgg                   4487


<210> 141
<211> 4509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FLC-2A3-1"

<400> 141
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gaccacctcc agcctgagcg ccagcctggg cgaccgggtg accatcagct      420

gccgggccag ccaggacatc agcaagtacc tgaactggta tcagcagaag cccgacggca      480

ccgtcaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc agccggttta      540

gcggcagcgg ctccggcacc gactacagcc tgaccatctc caacctggag caggaggaca      600

tcgccaccta cttttgccag cagggcaaca cactgcccta cacctttggc ggcggaacaa      660

agctggagat caccggcagc acctccggca gcggcaagcc tggcagcggc gagggcagca      720

ccaagggcga ggtgaagctg caggagagcg gccctggcct ggtggccccc agccagagcc      780

tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcccga ctacggcgtg tcctggatcc      840

ggcagccccc taggaagggc ctggagtggc tgggcgtgat ctggggcagc gagaccacct      900

actacaacag cgccctgaag agccggctga ccatcatcaa ggacaacagc aagagccagg      960

tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac tgtgccaagc     1020

actactacta cggcggcagc tacgccatgg actactgggg ccagggcacc agcgtgaccg     1080

tgtccagcaa gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg     1140

ccagccagcc cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc     1200

acaccagagg cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct     1260

gtggcgtgct gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataggagca     1320

agcggagcag aggcggccac agcgactaca tgaacatgac cccccggagg cctggcccca     1380

cccggaagca ctaccagccc tacgcccctc ccagggactt cgccgcctac cggagccggg     1440

tgaagttcag ccggagcgcc gacgcccctg cctaccagca gggccagaac cagctgtaca     1500

acgagctgaa cctgggccgg agggaggagt acgacgtgct ggacaagcgg agaggccggg     1560

accctgagat gggcggcaag ccccggagaa agaaccctca ggagggcctg tataacgaac     1620

tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc gagcggcgga     1680

ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag gatacctacg     1740

acgccctgca catgcaggcc ctgcccccca gaagagctaa gaggggaagc ggagagggca     1800

gaggaagtct gctaacatgc ggtgacgtcg aggagaatcc tggacctggc cccaagaaga     1860

aaaggaaggt ggcccccccc accgacgtga gcctgggcga cgagctgcac ctggacggcg     1920

aggacgtggc catggcccac gccgacgccc tggacgactt cgacctggac atgctgggcg     1980

acggcgacag ccccggcccc ggcttcaccc cccacgacag cgccccctac ggcgccctgg     2040

acatggccga cttcgagttc gagcagatgt tcaccgacgc cctgggcatc gacgagtacg     2100

gcggcgaatt cgagatgccc gtggacagga ttctggaggc cgaactcgcc gtggagcaga     2160

aaagcgacca gggcgtggag ggccccggcg gaaccggcgg cagcggcagc agccccaacg     2220

accccgtgac caacatctgc caggccgccg acaagcagct gttcaccctg gtggagtggg     2280

ccaagaggat tccccacttc agcagcctgc ccctggacga ccaggtgatc ctgctgaggg     2340

ccggatggaa cgagctgctg atcgccagct tcagccacag gagcatcgac gtgagggacg     2400

gcatcctgct ggccaccggc ctgcacgtcc ataggaacag cgcccacagc gccggagtgg     2460

gcgccatctt cgacagggtg ctgaccgagc tggtgagcaa gatgagggac atgaggatgg     2520

acaagaccga gctgggctgc ctgagggcca tcatcctgtt caaccccgag gtgaggggcc     2580

tgaaaagcgc ccaggaggtg gagctgctga gggagaaggt gtacgccgcc ctggaggagt     2640

acaccaggac cacccacccc gacgagcccg gcagattcgc caagctgctg ctgaggctgc     2700

ccagcctgag gagcatcggc ctgaagtgcc tggagcacct gttcttcttc aggctgatcg     2760

gcgacgtgcc catcgacacc ttcctgatgg agatgctgga gagccccagc gacagctgag     2820

catgcactag ttttataatt tcttcttcca gaatttctga cattttataa tttcttcttc     2880

cagaagactc acaacctcca tatggccacc atgaagctgc tgagcagcat cgagcaggct     2940

tgcgacatct gcaggctgaa gaagctgaag tgcagcaagg agaagcccaa gtgcgccaag     3000

tgcctgaaga acaactggga gtgcagatac agccccaaga ccaagaggag ccccctgacc     3060

agggcccacc tgaccgaggt ggagagcagg ctggagaggc tggagcagct gttcctgctg     3120

atcttcccca gggaggacct ggacatgatc ctgaagatgg acagcctgca agacatcaag     3180

gccctgctga ccggcctgtt cgtgcaggac aacgtgaaca aggacgccgt gaccgacagg     3240

ctggccagcg tggagaccga catgcccctg accctgaggc agcacaggat cagcgccacc     3300

agcagcagcg aggagagcag caacaagggc cagaggcagc tgaccgtgag ccccgagttt     3360

cccgggatca ggcccgagtg cgtggtgccc gagacccagt gcgccatgaa aaggaaggag     3420

aagaaggccc agaaggagaa ggacaagctg cccgtgagca ccaccaccgt cgatgaccac     3480

atgcccccca tcatgcagtg cgagcccccc ccccccgagg ccgccaggat tcacgaggtc     3540

gtgcccaggt tcctgagcga caagctgctg gtgaccaaca ggcagaagaa catcccccag     3600

ctgaccgcca accagcagtt cctgatcgcc aggctgatct ggtatcagga cggctacgag     3660

cagcccagcg acgaggacct gaaaaggatc acccagacct ggcagcaggc cgacgacgag     3720

aacgaggaga gcgacacccc cttcaggcag atcaccgaga tgaccatcct gaccgtgcag     3780

ctgatcgtgg agttcgccaa gggcctgccc ggattcgcca agatcagcca gcccgaccag     3840

atcaccctgc tgaaggcttg cagcagcgag gtgatgatgc tgagggtggc caggaggtac     3900

gacgccgcca gcgacagcat cctgttcgcc aacaaccagg cttacaccag ggacaactac     3960

aggaaggctg gcatggccga ggtgatcgag gacctcctgc acttctgcag atgtatgtac     4020

agcatggccc tggacaacat ccactacgcc ctgctgaccg ccgtggtgat cttcagcgac     4080

aggcccggcc tggagcagcc ccagctggtg gaggagatcc agaggtacta cctgaacacc     4140

ctgaggatct acatcctgaa ccagctgagc ggcagcgcca ggagcagcgt gatctacggc     4200

aagatcctga gcatcctgag cgagctgagg accctgggaa tgcagaacag caatatgtgt     4260

atcagcctga agctgaagaa caggaagctg ccccccttcc tggaggagat ttgggacgtg     4320

gccgacatga gccacaccca gccccccccc atcctggaga gccccaccaa cctgtgaaac     4380

ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat     4440

aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat     4500

catgtctgg                                                             4509


<210> 142
<211> 3155
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FLC-2A7-1"

<400> 142
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaaccc cgggaggtct atataagcag agctcgttta      180

gtgaaccctc attctggaga cggatcccga gccgagtgtt ttgacctcca tagaacagcc      240

gctaaatcca aggtaaggtc agaagagcta gcgccaccat gctgctgctg gtgaccagcc      300

tgctgctgtg tgagctgccc caccccgcct ttctgctgat ccccgacatc cagatgaccc      360

agaccacctc cagcctgagc gccagcctgg gcgaccgggt gaccatcagc tgccgggcca      420

gccaggacat cagcaagtac ctgaactggt atcagcagaa gcccgacggc accgtcaagc      480

tgctgatcta ccacaccagc cggctgcaca gcggcgtgcc cagccggttt agcggcagcg      540

gctccggcac cgactacagc ctgaccatct ccaacctgga gcaggaggac atcgccacct      600

acttttgcca gcagggcaac acactgccct acacctttgg cggcggaaca aagctggaga      660

tcaccggcag cacctccggc agcggcaagc ctggcagcgg cgagggcagc accaagggcg      720

aggtgaagct gcaggagagc ggccctggcc tggtggcccc cagccagagc ctgagcgtga      780

cctgtaccgt gtccggcgtg tccctgcccg actacggcgt gtcctggatc cggcagcccc      840

ctaggaaggg cctggagtgg ctgggcgtga tctggggcag cgagaccacc tactacaaca      900

gcgccctgaa gagccggctg accatcatca aggacaacag caagagccag gtgttcctga      960

agatgaacag cctgcagacc gacgacaccg ccatctacta ctgtgccaag cactactact     1020

acggcggcag ctacgccatg gactactggg gccagggcac cagcgtgacc gtgtccagca     1080

agcccaccac cacccctgcc cctagacctc caaccccagc ccctacaatc gccagccagc     1140

ccctgagcct gaggcccgaa gcctgtagac ctgccgctgg cggagccgtg cacaccagag     1200

gcctggattt cgcctgcgac atctacatct gggcccctct ggccggcacc tgtggcgtgc     1260

tgctgctgag cctggtcatc accctgtact gcaaccaccg gaataggagc aagcggagca     1320

gaggcggcca cagcgactac atgaacatga ccccccggag gcctggcccc acccggaagc     1380

actaccagcc ctacgcccct cccagggact tcgccgccta ccggagccgg gtgaagttca     1440

gccggagcgc cgacgcccct gcctaccagc agggccagaa ccagctgtac aacgagctga     1500

acctgggccg gagggaggag tacgacgtgc tggacaagcg gagaggccgg gaccctgaga     1560

tgggcggcaa gccccggaga aagaaccctc aggagggcct gtataacgaa ctgcagaaag     1620

acaagatggc cgaggcctac agcgagatcg gcatgaaggg cgagcggcgg aggggcaagg     1680

gccacgacgg cctgtaccag ggcctgagca ccgccaccaa ggatacctac gacgccctgc     1740

acatgcaggc cctgcccccc agaagagcta agaggggaag cggagagggc agaggaagtc     1800

tgctaacatg cggtgacgtc gaggagaatc ctggacctga ttggacctgg attctgtttc     1860

tggtggccgc tgccacaaga gtgcacagca actgggtgaa tgtgatcagc gacctgaaga     1920

agatcgagga tctgatccag agcatgcaca ttgatgccac cctgtacaca gaatctgatg     1980

tgcaccctag ctgtaaagtg accgccatga agtgttttct gctggagctg caggtgattt     2040

ctctggaaag cggagatgcc tctatccacg acacagtgga gaatctgatc atcctggcca     2100

acaatagcct gagcagcaat ggcaatgtga cagagtctgg ctgtaaggag tgtgaggagc     2160

tggaggagaa gaacatcaag gagtttctgc agagctttgt gcacatcgtg cagatgttca     2220

tcaatacaag ctctggcgga ggatctggag gaggcggatc tggaggagga ggcagtggag     2280

gcggaggatc tggcggagga tctctgcaga ttacatgccc tcctccaatg tctgtggagc     2340

acgccgatat ttgggtgaag tcctacagcc tgtacagcag agagagatac atctgcaaca     2400

gcggctttaa gagaaaggcc ggcacctctt ctctgacaga gtgcgtgctg aataaggcca     2460

caaatgtggc ccactggaca acacctagcc tgaagtgcat tagagatcct gccctggtcc     2520

accagaggcc tgcccctcca tctacagtga caacagccgg agtgacacct cagcctgaat     2580

ctctgagccc ttctggaaaa gaacctgccg ccagctctcc tagctctaat aataccgccg     2640

ccacaacagc cgccattgtg cctggatctc agctgatgcc tagcaagtct cctagcacag     2700

gcacaacaga gatcagcagc cacgaatctt ctcacggaac accttctcag accaccgcca     2760

agaattggga gctgacagcc tctgcctctc accagcctcc aggagtgtat cctcagggcc     2820

actctgatac aacagtggcc atcagcacat ctacagtgct gctgtgtgga ctgtctgccg     2880

tgtctctgct ggcctgttac ctgaagtcta gacagacacc tcctctggcc tctgtggaga     2940

tggaggccat ggaagccctg cctgtgacat ggggaacaag cagcagagat gaggacctgg     3000

agaattgttc tcaccacctg tgaaacttgt ttattgcagc ttataatggt tacaaataaa     3060

gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt     3120

tgtccaaact catcaatgta tcttatcatg tctgg                                3155


<210> 143
<211> 3476
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FLC-2A5-2"

<400> 143
attgttcgga gcagtgcggc gcgtttagcg gagtactgtc ctccgatatt aatcggggca       60

gactattccg gggtttaccg gcgcactctc gcccgaactt caccggcggt ctttcgtccg      120

tgctttatcg gggcggatca ctccgaaccc cgggaggtct atataagcag agctcgttta      180

gtgaaccctc attctggaga cggatcccga gccgagtgtt ttgacctcca tagaacagcc      240

gctaaatcca aggtaaggtc agaagagcta gcgccaccat ggattggacc tggattctgt      300

ttctggtggc cgctgccaca agagtgcaca gcaactgggt gaatgtgatc agcgacctga      360

agaagatcga ggatctgatc cagagcatgc acattgatgc caccctgtac acagaatctg      420

atgtgcaccc tagctgtaaa gtgaccgcca tgaagtgttt tctgctggag ctgcaggtga      480

tttctctgga aagcggagat gcctctatcc acgacacagt ggagaatctg atcatcctgg      540

ccaacaatag cctgagcagc aatggcaatg tgacagagtc tggctgtaag gagtgtgagg      600

agctggagga gaagaacatc aaggagtttc tgcagagctt tgtgcacatc gtgcagatgt      660

tcatcaatac aagctctggc ggaggatctg gaggaggcgg atctggagga ggaggcagtg      720

gaggcggagg atctggcgga ggatctctgc agattacatg ccctcctcca atgtctgtgg      780

agcacgccga tatttgggtg aagtcctaca gcctgtacag cagagagaga tacatctgca      840

acagcggctt taagagaaag gccggcacct cttctctgac agagtgcgtg ctgaataagg      900

ccacaaatgt ggcccactgg acaacaccta gcctgaagtg cattagagat cctgccctgg      960

tccaccagag gcctgcccct ccatctacag tgacaacagc cggagtgaca cctcagcctg     1020

aatctctgag cccttctgga aaagaacctg ccgccagctc tcctagctct aataataccg     1080

ccgccacaac agccgccatt gtgcctggat ctcagctgat gcctagcaag tctcctagca     1140

caggcacaac agagatcagc agccacgaat cttctcacgg aacaccttct cagaccaccg     1200

ccaagaattg ggagctgaca gcctctgcct ctcaccagcc tccaggagtg tatcctcagg     1260

gccactctga tacaacagtg gccatcagca catctacagt gctgctgtgt ggactgtctg     1320

ccgtgtctct gctggcctgt tacctgaagt ctagacagac acctcctctg gcctctgtgg     1380

agatggaggc catggaagcc ctgcctgtga catggggaac aagcagcaga gatgaggacc     1440

tggagaattg ttctcaccac ctgtgaatcg attaatctag cggccctaga cgagcagaca     1500

tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct     1560

ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac     1620

aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag atgtgggagg     1680

ttttttaaag caagtaaaac ctctacaaat gtggtaaaat ccgataagcg tacctagagg     1740

ccgcctagag attcgtgggg gactcgagga taggcggcgg ttgggtgtgc gacatgtccg     1800

ccacatccca gatctcctcg aggaaaggcg gcagctttct gttcttgagc ttgagggaga     1860

tgcacatgtt ggagttttgc atgccgagcg tgcgtagctc agagaggatt gagaggatct     1920

tgccgtatat gacggacgaa cgcgccgacc cgctcagctg gttcaggata tagatgcgga     1980

gcgtattcag gtagtaccgc tggatctctt ccaccagttg cggctgctcc aaccctggcc     2040

ggtcagaaaa gatgacgaca gccgtgagca gcgcgtaatg gatgttgtcc aacgccatag     2100

agtacatgca ccggcagaag tgcagtagat cctcgatgac ctcggccatg ccagccttgc     2160

ggtagttgtc gcgagtgtac gcttggttgt tcgcgaacag aatactgtct gaggccgcat     2220

cgtatcgtcg cgcgactcgg agcatcatta cctcacttga gcaagcctta agcagcgtaa     2280

tttgatcagg ctgcgagatc ttggcgaacc ctggcaatcc cttcgcgaac tccacgataa     2340

gttggaccgt gaggatagtc atctctgtga tctggcggaa gggagtgtcc gactcttcgt     2400

tttcatcgtc cgcttgctgc cacgtctgcg taatcctctt caaatcttca tcagaaggct     2460

gctcgtaccc gtcctggtac cagatgagcc tggcgataag gaactgctgg ttggctgtca     2520

actgggggat gtttttctgc cggtttgtca ccaacagctt gtcggagaga aaccttggga     2580

ccacttcgtg aatccttgct gcttcaggag gtggaggttc acactgcata atgggcggca     2640

tgtggtcgtc caccgtcgtc gtgctgacag gcagtttgtc cttctccttc tgtgctttct     2700

tctctttccg cttcatggcg cactgagtct cgggtactac gcactcaggc cgcccgggaa     2760

actcggggct cacggtcagc tgcctctggc ccttgttgct gctctcctcg ctgctgctgg     2820

tggcgctgat cctgtgctgc ctcagggtca ggggcatgtc ggtctccacg ctggccagcc     2880

tgtcggtcac ggcgtccttg ttcacgttgt cctgcacgaa caggccggtc agcagggcct     2940

tgatgtcttg caggctgtcc atcttcagga tcatgtccag gtcctccctg gggaagatca     3000

gcaggaacag ctgctccagc ctctccagcc tgctctccac ctcggtcagg tgggccctgg     3060

tcagggggct cctcttggtc ttggggctgt atctgcactc ccagttgttc ttcaggcact     3120

tggcgcactt gggcttctcc ttgctgcact tcagcttctt cagcctgcag atgtcgcaag     3180

cctgctcgat gctgctcagc agcttcatgg tggcccgaaa agcacacaat gcctgtgttc     3240

tggcggcaaa cccgttgcga aaaagaacgt tcacggcgac tactgcactt atatacggtt     3300

ctcccccacc ctcgggaaaa aggcggagcc agtacacgac atcactttcc cagtttaccc     3360

cgcgccacct tctctaggca ccggttcaat cgccgacccc ctccccccaa cttctcgggg     3420

actgtgggcg atgtgcgctc tgcccactga cgggcaccgg agcctcacgc acgctc         3476


<210> 144
<211> 3503
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="FLC-2A6-1"

<400> 144
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gaccacctcc agcctgagcg ccagcctggg cgaccgggtg accatcagct      420

gccgggccag ccaggacatc agcaagtacc tgaactggta tcagcagaag cccgacggca      480

ccgtcaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc agccggttta      540

gcggcagcgg ctccggcacc gactacagcc tgaccatctc caacctggag caggaggaca      600

tcgccaccta cttttgccag cagggcaaca cactgcccta cacctttggc ggcggaacaa      660

agctggagat caccggcagc acctccggca gcggcaagcc tggcagcggc gagggcagca      720

ccaagggcga ggtgaagctg caggagagcg gccctggcct ggtggccccc agccagagcc      780

tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcccga ctacggcgtg tcctggatcc      840

ggcagccccc taggaagggc ctggagtggc tgggcgtgat ctggggcagc gagaccacct      900

actacaacag cgccctgaag agccggctga ccatcatcaa ggacaacagc aagagccagg      960

tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac tgtgccaagc     1020

actactacta cggcggcagc tacgccatgg actactgggg ccagggcacc agcgtgaccg     1080

tgtccagcaa gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg     1140

ccagccagcc cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc     1200

acaccagagg cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct     1260

gtggcgtgct gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataggagca     1320

agcggagcag aggcggccac agcgactaca tgaacatgac cccccggagg cctggcccca     1380

cccggaagca ctaccagccc tacgcccctc ccagggactt cgccgcctac cggagccggg     1440

tgaagttcag ccggagcgcc gacgcccctg cctaccagca gggccagaac cagctgtaca     1500

acgagctgaa cctgggccgg agggaggagt acgacgtgct ggacaagcgg agaggccggg     1560

accctgagat gggcggcaag ccccggagaa agaaccctca ggagggcctg tataacgaac     1620

tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc gagcggcgga     1680

ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag gatacctacg     1740

acgccctgca catgcaggcc ctgcccccca gatgaatcga ttaatctagc ggccctagac     1800

gagcagacat gataagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa     1860

aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct     1920

gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggaga     1980

tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg tggtaaaatc cgataagcgt     2040

acctagaggc tcacaggtgg tgagaacaat tctccaggtc ctcatctctg ctgcttgttc     2100

cccatgtcac aggcagggct tccatggcct ccatctccac agaggccaga ggaggtgtct     2160

gtctagactt caggtaacag gccagcagag acacggcaga cagtccacac agcagcactg     2220

tagatgtgct gatggccact gttgtatcag agtggccctg aggatacact cctggaggct     2280

ggtgagaggc agaggctgtc agctcccaat tcttggcggt ggtctgagaa ggtgttccgt     2340

gagaagattc gtggctgctg atctctgttg tgcctgtgct aggagacttg ctaggcatca     2400

gctgagatcc aggcacaatg gcggctgttg tggcggcggt attattagag ctaggagagc     2460

tggcggcagg ttcttttcca gaagggctca gagattcagg ctgaggtgtc actccggctg     2520

ttgtcactgt agatggaggg gcaggcctct ggtggaccag ggcaggatct ctaatgcact     2580

tcaggctagg tgttgtccag tgggccacat ttgtggcctt attcagcacg cactctgtca     2640

gagaagaggt gccggccttt ctcttaaagc cgctgttgca gatgtatctc tctctgctgt     2700

acaggctgta ggacttcacc caaatatcgg cgtgctccac agacattgga ggagggcatg     2760

taatctgcag agatcctccg ccagatcctc cgcctccact gcctcctcct ccagatccgc     2820

ctcctccaga tcctccgcca gagcttgtat tgatgaacat ctgcacgatg tgcacaaagc     2880

tctgcagaaa ctccttgatg ttcttctcct ccagctcctc acactcctta cagccagact     2940

ctgtcacatt gccattgctg ctcaggctat tgttggccag gatgatcaga ttctccactg     3000

tgtcgtggat agaggcatct ccgctttcca gagaaatcac ctgcagctcc agcagaaaac     3060

acttcatggc ggtcacttta cagctagggt gcacatcaga ttctgtgtac agggtggcat     3120

caatgtgcat gctctggatc agatcctcga tcttcttcag gtcgctgatc acattcaccc     3180

agttgctgtg cactcttgtg gcagcggcca ccagaaacag aatccaggtc caatccatgg     3240

tggcgctagc ccgaaaagca cacaatgctt ctatggaggt caaaacactc ggctcgggat     3300

ccgtctccag aatgagggtt cactaaacga gctctgctta tatagacctc ccggggttcg     3360

gagtgatccg ccccgataaa gcacggacga aagaccgccg gtgaagttcg ggcgagagtg     3420

cgccggtaaa ccccggaata gtctgccccg attaatatcg gaggacagta ctccgctaaa     3480

cgcgccgcac tgctccgaac aat                                             3503


<210> 145
<211> 4079
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<220>
<221> source
<223> /note="XON-00(h)"

<400> 145
gagcgtgcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc       60

gagaagttgg ggggaggggg tcggcgattg aaccggtgcc tagagaaggt ggcgcggggt      120

aaactgggaa agtgatgtcg tgtactggct ccgccttttt cccgagggtg ggggagaacc      180

gtatataagt gcagtagtcg ccgtgaacgt tctttttcgc aacgggtttg ccgccagaac      240

acagcagccg ctaaatccaa ggtaaggtca gaagagctag cgccaccatg ctgctgctgg      300

tgaccagcct gctgctgtgt gagctgcccc accccgcctt tctgctgatc cccgacatcc      360

agatgaccca gaccacctcc agcctgagcg ccagcctggg cgaccgggtg accatcagct      420

gccgggccag ccaggacatc agcaagtacc tgaactggta tcagcagaag cccgacggca      480

ccgtcaagct gctgatctac cacaccagcc ggctgcacag cggcgtgccc agccggttta      540

gcggcagcgg ctccggcacc gactacagcc tgaccatctc caacctggag caggaggaca      600

tcgccaccta cttttgccag cagggcaaca cactgcccta cacctttggc ggcggaacaa      660

agctggagat caccggcagc acctccggca gcggcaagcc tggcagcggc gagggcagca      720

ccaagggcga ggtgaagctg caggagagcg gccctggcct ggtggccccc agccagagcc      780

tgagcgtgac ctgtaccgtg tccggcgtgt ccctgcccga ctacggcgtg tcctggatcc      840

ggcagccccc taggaagggc ctggagtggc tgggcgtgat ctggggcagc gagaccacct      900

actacaacag cgccctgaag agccggctga ccatcatcaa ggacaacagc aagagccagg      960

tgttcctgaa gatgaacagc ctgcagaccg acgacaccgc catctactac tgtgccaagc     1020

actactacta cggcggcagc tacgccatgg actactgggg ccagggcacc agcgtgaccg     1080

tgtccagcaa gcccaccacc acccctgccc ctagacctcc aaccccagcc cctacaatcg     1140

ccagccagcc cctgagcctg aggcccgaag cctgtagacc tgccgctggc ggagccgtgc     1200

acaccagagg cctggatttc gcctgcgaca tctacatctg ggcccctctg gccggcacct     1260

gtggcgtgct gctgctgagc ctggtcatca ccctgtactg caaccaccgg aataggagca     1320

agcggagcag aggcggccac agcgactaca tgaacatgac cccccggagg cctggcccca     1380

cccggaagca ctaccagccc tacgcccctc ccagggactt cgccgcctac cggagccggg     1440

tgaagttcag ccggagcgcc gacgcccctg cctaccagca gggccagaac cagctgtaca     1500

acgagctgaa cctgggccgg agggaggagt acgacgtgct ggacaagcgg agaggccggg     1560

accctgagat gggcggcaag ccccggagaa agaaccctca ggagggcctg tataacgaac     1620

tgcagaaaga caagatggcc gaggcctaca gcgagatcgg catgaagggc gagcggcgga     1680

ggggcaaggg ccacgacggc ctgtaccagg gcctgagcac cgccaccaag gatacctacg     1740

acgccctgca catgcaggcc ctgcccccca gaagagctaa gaggggaagc ggagagggca     1800

gaggaagtct gctaacatgc ggtgacgtcg aggagaatcc tggacctatg cttctcctgg     1860

tgacaagcct tctgctctgt gagttaccac acccagcatt cctcctgatc ccacgcaaag     1920

tgtgtaacgg aataggtatt ggtgaattta aagactcact ctccataaat gctacgaata     1980

ttaaacactt caaaaactgc acctccatca gtggcgatct ccacatcctg ccggtggcat     2040

ttaggggtga ctccttcaca catactcctc ctctggatcc acaggaactg gatattctga     2100

aaaccgtaaa ggaaatcaca gggtttttgc tgattcaggc ttggcctgaa aacaggacgg     2160

acctccatgc ctttgagaac ctagaaatca tacgcggcag gaccaagcaa catggtcagt     2220

tttctcttgc agtcgtcagc ctgaacataa catccttggg attacgctcc ctcaaggaga     2280

taagtgatgg agatgtgata atttcaggaa acaaaaattt gtgctatgca aatacaataa     2340

actggaaaaa actgtttggg acctccggtc agaaaaccaa aattataagc aacagaggtg     2400

aaaacagctg caaggccaca ggccaggtct gccatgcctt gtgctccccc gagggctgct     2460

ggggcccgga gcccagggac tgcgtctctt gccggaatgt cagccgaggc agggaatgcg     2520

tggacaagtg caaccttctg gagggtgagc caagggagtt tgtggagaac tctgagtgca     2580

tacagtgcca cccagagtgc ctgcctcagg ccatgaacat cacctgcaca ggacggggac     2640

cagacaactg tatccagtgt gcccactaca ttgacggccc ccactgcgtc aagacctgcc     2700

cggcaggagt catgggagaa aacaacaccc tggtctggaa gtacgcagac gccggccatg     2760

tgtgccacct gtgccatcca aactgcacct acggatgcac tgggccaggt cttgaaggct     2820

gtccaacgaa tgggcctaag atcccgtcca tcgccactgg gatggtgggg gccctcctct     2880

tgctgctggt ggtggccctg gggatcggcc tcttcatgga gggcagagga agtctgctaa     2940

catgcggtga cgtcgaggag aatcctggac ctatgggccc caagaagaaa aggaaggtgg     3000

ccccccccac cgacgtgagc ctgggcgacg agctgcacct ggacggcgag gacgtggcca     3060

tggcccacgc cgacgccctg gacgacttcg acctggacat gctgggcgac ggcgacagcc     3120

ccggccccgg cttcaccccc cacgacagcg ccccctacgg cgccctggac atggccgact     3180

tcgagttcga gcagatgttc accgacgccc tgggcatcga cgagtacggc ggcgaattcg     3240

agatgcccgt ggacaggatt ctggaggccg aactcgccgt ggagcagaaa agcgaccagg     3300

gcgtggaggg ccccggcgga accggcggca gcggcagcag ccccaacgac cccgtgacca     3360

acatctgcca ggccgccgac aagcagctgt tcaccctggt ggagtgggcc aagaggattc     3420

cccacttcag cagcctgccc ctggacgacc aggtgatcct gctgagggcc ggatggaacg     3480

agctgctgat cgccagcttc agccacagga gcatcgacgt gagggacggc atcctgctgg     3540

ccaccggcct gcacgtccat aggaacagcg cccacagcgc cggagtgggc gccatcttcg     3600

acagggtgct gaccgagctg gtgagcaaga tgagggacat gaggatggac aagaccgagc     3660

tgggctgcct gagggccatc atcctgttca accccgaggt gaggggcctg aaaagcgccc     3720

aggaggtgga gctgctgagg gagaaggtgt acgccgccct ggaggagtac accaggacca     3780

cccaccccga cgagcccggc agattcgcca agctgctgct gaggctgccc agcctgagga     3840

gcatcggcct gaagtgcctg gagcacctgt tcttcttcag gctgatcggc gacgtgccca     3900

tcgacacctt cctgatggag atgctggaga gccccagcga cagctgaaac ttgtttattg     3960

cagcttataa tggttacaaa taaagcaata gcatcacaaa tttcacaaat aaagcatttt     4020

tttcactgca ttctagttgt ggtttgtcca aactcatcaa tgtatcttat catgtctgg      4079


<210> 146
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Whitlow Linker"

<400> 146
Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210> 147
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Linker"

<400> 147
Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln 
            20                  25      


<210> 148
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GSG linker"

<400> 148
Gly Ser Gly 
1           


<210> 149
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="SGSG linker"

<400> 149
Ser Gly Ser Gly 
1               


<210> 150
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="(G4S)3 linker"

<400> 150
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 151
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Furin cleavage site/ Furinlink1"

<400> 151
Arg Ala Lys Arg 
1               


<210> 152
<211> 28
<212> PRT
<213> Foot-and-mouth disease virus

<220>
<221> source
<223> /note="Fmdv"

<400> 152
Arg Ala Lys Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
1               5                   10                  15      


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25              


<210> 153
<211> 18
<212> PRT
<213> Thosea asigna virus

<220>
<221> source
<223> /note="Thosea asigna virus 2A region (T2A)"

<400> 153
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 154
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Furin-GSG-T2A"

<400> 154
Arg Ala Lys Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210> 155
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Furin-SGSG-T2A"

<400> 155
Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      


<210> 156
<211> 19
<212> PRT
<213> Porcine teschovirus

<220>
<221> source
<223> /note="Porcine teschovirus-1 2A region (P2A)"

<400> 156
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 157
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GSG-P2A"

<400> 157
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 158
<211> 20
<212> PRT
<213> Equine rhinitis A virus

<220>
<221> source
<223> /note="Equine rhinitis A virus 2A region (E2A)"

<400> 158
Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 159
<211> 22
<212> PRT
<213> Foot-and-mouth disease virus

<220>
<221> source
<223> /note="Foot-and-mouth disease virus 2A region (F2A)"

<400> 159
Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210> 160
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="FP2A"

<400> 160
Arg Ala Lys Arg Ala Pro Val Lys Gln Gly Ser Gly Ala Thr Asn Phe 
1               5                   10                  15      


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25                  30      


<210> 161
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Linker-GSG"

<400> 161
Ala Pro Val Lys Gln Gly Ser Gly 
1               5               


<210> 162
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Linker"

<400> 162
Ala Pro Val Lys Gln 
1               5   


<210> 163
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="GM-CSFR-alpha  signal peptide"

<400> 163
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210> 164
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Ig Kappa signal peptide"

<400> 164
Met Arg Leu Pro Ala Gln Leu Leu Gly Leu Leu Met Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Ser Gly 
            20  


<210> 165
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="IgE signal peptide"

<400> 165
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210> 166
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CD8-alpha signal peptide"

<400> 166
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210> 167
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="TVB2(T21A)signal peptide"

<400> 167
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Ala 
            20      


<210> 168
<211> 24
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CD52 signal peptide"

<400> 168
Met Lys Arg Phe Leu Phe Leu Leu Leu Thr Ile Ser Leu Leu Val Met 
1               5                   10                  15      


Val Gln Ile Gln Thr Gly Leu Ser 
            20                  


<210> 169
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="Low-affinity nerve growth factor receptor 
      (LNGFR, TNFRSF16) signal peptide"

<400> 169
Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala 
            20                  25              


<210> 170
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD8-alpha hinge region"

<400> 170
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45          


<210> 171
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD8 alpha 2x"

<400> 171
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
        35                  40                  45              


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                85                  90                  


<210> 172
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD8 alpha 3x"

<400> 172
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
        35                  40                  45              


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro 
                85                  90                  95      


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            100                 105                 110         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
        115                 120                 125             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    130                 135                 140     


<210> 173
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD8 alpha 4x"

<400> 173
Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
        35                  40                  45              


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
    50                  55                  60                  


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala 
65                  70                  75                  80  


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro 
                85                  90                  95      


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
            100                 105                 110         


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly 
        115                 120                 125             


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys Pro Thr 
    130                 135                 140                 


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
145                 150                 155                 160 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
                165                 170                 175     


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            180                 185             


<210> 174
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CD8-alpha TM domain"

<400> 174
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
            20                  25              


<210> 175
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="CD28 TM domain"

<400> 175
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 176
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD28 signaling domain"

<400> 176
Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210> 177
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD3 zeta signaling domain"

<400> 177
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210> 178
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="4-1BB signaling domain"

<400> 178
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210> 179
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220>
<221> source
<223> /note="DNAX-activation protein 10 (DAP 10) Signaling 
      Domain"

<400> 179
Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210> 180
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="DNAX-activation protein 12 (DAP12) Signaling 
      Domain"

<400> 180
Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210> 181
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="VP16 activation domain"

<400> 181
Gly Pro Lys Lys Lys Arg Lys Val Ala Pro Pro Thr Asp Val Ser Leu 
1               5                   10                  15      


Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala His Ala 
            20                  25                  30          


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser 
        35                  40                  45              


Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu 
    50                  55                  60                  


Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly 
65                  70                  75                  80  


Ile Asp Glu Tyr Gly Gly 
                85      


<210> 182
<211> 235
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Retinoid x receptor (RxR)"

<400> 182
Glu Met Pro Val Asp Arg Ile Leu Glu Ala Glu Leu Ala Val Glu Gln 
1               5                   10                  15      


Lys Ser Asp Gln Gly Val Glu Gly Pro Gly Gly Thr Gly Gly Ser Gly 
            20                  25                  30          


Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala Asp Lys 
        35                  40                  45              


Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His Phe Ser 
    50                  55                  60                  


Ser Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly Trp Asn 
65                  70                  75                  80  


Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Asp Val Arg Asp 
                85                  90                  95      


Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser Ala His 
            100                 105                 110         


Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu Leu Val 
        115                 120                 125             


Ser Lys Met Arg Asp Met Arg Met Asp Lys Thr Glu Leu Gly Cys Leu 
    130                 135                 140                 


Arg Ala Ile Ile Leu Phe Asn Pro Glu Val Arg Gly Leu Lys Ser Ala 
145                 150                 155                 160 


Gln Glu Val Glu Leu Leu Arg Glu Lys Val Tyr Ala Ala Leu Glu Glu 
                165                 170                 175     


Tyr Thr Arg Thr Thr His Pro Asp Glu Pro Gly Arg Phe Ala Lys Leu 
            180                 185                 190         


Leu Leu Arg Leu Pro Ser Leu Arg Ser Ile Gly Leu Lys Cys Leu Glu 
        195                 200                 205             


His Leu Phe Phe Phe Arg Leu Ile Gly Asp Val Pro Ile Asp Thr Phe 
    210                 215                 220                 


Leu Met Glu Met Leu Glu Ser Pro Ser Asp Ser 
225                 230                 235 


<210> 183
<211> 323
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="VP16-linker-RxR"

<400> 183
Gly Pro Lys Lys Lys Arg Lys Val Ala Pro Pro Thr Asp Val Ser Leu 
1               5                   10                  15      


Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala Met Ala His Ala 
            20                  25                  30          


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Asp Gly Asp Ser 
        35                  40                  45              


Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro Tyr Gly Ala Leu 
    50                  55                  60                  


Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr Asp Ala Leu Gly 
65                  70                  75                  80  


Ile Asp Glu Tyr Gly Gly Glu Phe Glu Met Pro Val Asp Arg Ile Leu 
                85                  90                  95      


Glu Ala Glu Leu Ala Val Glu Gln Lys Ser Asp Gln Gly Val Glu Gly 
            100                 105                 110         


Pro Gly Gly Thr Gly Gly Ser Gly Ser Ser Pro Asn Asp Pro Val Thr 
        115                 120                 125             


Asn Ile Cys Gln Ala Ala Asp Lys Gln Leu Phe Thr Leu Val Glu Trp 
    130                 135                 140                 


Ala Lys Arg Ile Pro His Phe Ser Ser Leu Pro Leu Asp Asp Gln Val 
145                 150                 155                 160 


Ile Leu Leu Arg Ala Gly Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser 
                165                 170                 175     


His Arg Ser Ile Asp Val Arg Asp Gly Ile Leu Leu Ala Thr Gly Leu 
            180                 185                 190         


His Val His Arg Asn Ser Ala His Ser Ala Gly Val Gly Ala Ile Phe 
        195                 200                 205             


Asp Arg Val Leu Thr Glu Leu Val Ser Lys Met Arg Asp Met Arg Met 
    210                 215                 220                 


Asp Lys Thr Glu Leu Gly Cys Leu Arg Ala Ile Ile Leu Phe Asn Pro 
225                 230                 235                 240 


Glu Val Arg Gly Leu Lys Ser Ala Gln Glu Val Glu Leu Leu Arg Glu 
                245                 250                 255     


Lys Val Tyr Ala Ala Leu Glu Glu Tyr Thr Arg Thr Thr His Pro Asp 
            260                 265                 270         


Glu Pro Gly Arg Phe Ala Lys Leu Leu Leu Arg Leu Pro Ser Leu Arg 
        275                 280                 285             


Ser Ile Gly Leu Lys Cys Leu Glu His Leu Phe Phe Phe Arg Leu Ile 
    290                 295                 300                 


Gly Asp Val Pro Ile Asp Thr Phe Leu Met Glu Met Leu Glu Ser Pro 
305                 310                 315                 320 


Ser Asp Ser 
            


<210> 184
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="GAL4 DNA Binding Domain"

<400> 184
Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Pro Glu Phe 
145                 150 


<210> 185
<211> 336
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ecdysone Receptor Ligand Binding Domain 
      - VY variant (EcR)"

<400> 185
Ile Arg Pro Glu Cys Val Val Pro Glu Thr Gln Cys Ala Met Lys Arg 
1               5                   10                  15      


Lys Glu Lys Lys Ala Gln Lys Glu Lys Asp Lys Leu Pro Val Ser Thr 
            20                  25                  30          


Thr Thr Val Asp Asp His Met Pro Pro Ile Met Gln Cys Glu Pro Pro 
        35                  40                  45              


Pro Pro Glu Ala Ala Arg Ile His Glu Val Val Pro Arg Phe Leu Ser 
    50                  55                  60                  


Asp Lys Leu Leu Val Thr Asn Arg Gln Lys Asn Ile Pro Gln Leu Thr 
65                  70                  75                  80  


Ala Asn Gln Gln Phe Leu Ile Ala Arg Leu Ile Trp Tyr Gln Asp Gly 
                85                  90                  95      


Tyr Glu Gln Pro Ser Asp Glu Asp Leu Lys Arg Ile Thr Gln Thr Trp 
            100                 105                 110         


Gln Gln Ala Asp Asp Glu Asn Glu Glu Ser Asp Thr Pro Phe Arg Gln 
        115                 120                 125             


Ile Thr Glu Met Thr Ile Leu Thr Val Gln Leu Ile Val Glu Phe Ala 
    130                 135                 140                 


Lys Gly Leu Pro Gly Phe Ala Lys Ile Ser Gln Pro Asp Gln Ile Thr 
145                 150                 155                 160 


Leu Leu Lys Ala Cys Ser Ser Glu Val Met Met Leu Arg Val Ala Arg 
                165                 170                 175     


Arg Tyr Asp Ala Ala Ser Asp Ser Ile Leu Phe Ala Asn Asn Gln Ala 
            180                 185                 190         


Tyr Thr Arg Asp Asn Tyr Arg Lys Ala Gly Met Ala Glu Val Ile Glu 
        195                 200                 205             


Asp Leu Leu His Phe Cys Arg Cys Met Tyr Ser Met Ala Leu Asp Asn 
    210                 215                 220                 


Ile His Tyr Ala Leu Leu Thr Ala Val Val Ile Phe Ser Asp Arg Pro 
225                 230                 235                 240 


Gly Leu Glu Gln Pro Gln Leu Val Glu Glu Ile Gln Arg Tyr Tyr Leu 
                245                 250                 255     


Asn Thr Leu Arg Ile Tyr Ile Leu Asn Gln Leu Ser Gly Ser Ala Arg 
            260                 265                 270         


Ser Ser Val Ile Tyr Gly Lys Ile Leu Ser Ile Leu Ser Glu Leu Arg 
        275                 280                 285             


Thr Leu Gly Met Gln Asn Ser Asn Met Cys Ile Ser Leu Lys Leu Lys 
    290                 295                 300                 


Asn Arg Lys Leu Pro Pro Phe Leu Glu Glu Ile Trp Asp Val Ala Asp 
305                 310                 315                 320 


Met Ser His Thr Gln Pro Pro Pro Ile Leu Glu Ser Pro Thr Asn Leu 
                325                 330                 335     


<210> 186
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Ecdysone Receptor Ligand Binding Domain 
      - VY variant (EcR)"

<400> 186
Arg Pro Glu Cys Val Val Pro Glu Thr Gln Cys Ala Met Lys Arg Lys 
1               5                   10                  15      


Glu Lys Lys Ala Gln Lys Glu Lys Asp Lys Leu Pro Val Ser Thr Thr 
            20                  25                  30          


Thr Val Asp Asp His Met Pro Pro Ile Met Gln Cys Glu Pro Pro Pro 
        35                  40                  45              


Pro Glu Ala Ala Arg Ile His Glu Val Val Pro Arg Phe Leu Ser Asp 
    50                  55                  60                  


Lys Leu Leu Val Thr Asn Arg Gln Lys Asn Ile Pro Gln Leu Thr Ala 
65                  70                  75                  80  


Asn Gln Gln Phe Leu Ile Ala Arg Leu Ile Trp Tyr Gln Asp Gly Tyr 
                85                  90                  95      


Glu Gln Pro Ser Asp Glu Asp Leu Lys Arg Ile Thr Gln Thr Trp Gln 
            100                 105                 110         


Gln Ala Asp Asp Glu Asn Glu Glu Ser Asp Thr Pro Phe Arg Gln Ile 
        115                 120                 125             


Thr Glu Met Thr Ile Leu Thr Val Gln Leu Ile Val Glu Phe Ala Lys 
    130                 135                 140                 


Gly Leu Pro Gly Phe Ala Lys Ile Ser Gln Pro Asp Gln Ile Thr Leu 
145                 150                 155                 160 


Leu Lys Ala Cys Ser Ser Glu Val Met Met Leu Arg Val Ala Arg Arg 
                165                 170                 175     


Tyr Asp Ala Ala Ser Asp Ser Ile Leu Phe Ala Asn Asn Gln Ala Tyr 
            180                 185                 190         


Thr Arg Asp Asn Tyr Arg Lys Ala Gly Met Ala Glu Val Ile Glu Asp 
        195                 200                 205             


Leu Leu His Phe Cys Arg Cys Met Tyr Ser Met Ala Leu Asp Asn Ile 
    210                 215                 220                 


His Tyr Ala Leu Leu Thr Ala Val Val Ile Phe Ser Asp Arg Pro Gly 
225                 230                 235                 240 


Leu Glu Gln Pro Gln Leu Val Glu Glu Ile Gln Arg Tyr Tyr Leu Asn 
                245                 250                 255     


Thr Leu Arg Ile Tyr Ile Leu Asn Gln Leu Ser Gly Ser Ala Arg Ser 
            260                 265                 270         


Ser Val Ile Tyr Gly Lys Ile Leu Ser Ile Leu Ser Glu Leu Arg Thr 
        275                 280                 285             


Leu Gly Met Gln Asn Ser Asn Met Cys Ile Ser Leu Lys Leu Lys Asn 
    290                 295                 300                 


Arg Lys Leu Pro Pro Phe Leu Glu Glu Ile Trp Asp Val Ala Asp Met 
305                 310                 315                 320 


Ser His Thr Gln Pro Pro Pro Ile Leu Glu Ser Pro Thr Asn Leu 
                325                 330                 335 


<210> 187
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="GAL4-Linker-EcR"

<400> 187
Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Pro Glu Phe Pro Gly Ile Arg Pro Glu Cys Val Val Pro 
145                 150                 155                 160 


Glu Thr Gln Cys Ala Met Lys Arg Lys Glu Lys Lys Ala Gln Lys Glu 
                165                 170                 175     


Lys Asp Lys Leu Pro Val Ser Thr Thr Thr Val Asp Asp His Met Pro 
            180                 185                 190         


Pro Ile Met Gln Cys Glu Pro Pro Pro Pro Glu Ala Ala Arg Ile His 
        195                 200                 205             


Glu Val Val Pro Arg Phe Leu Ser Asp Lys Leu Leu Val Thr Asn Arg 
    210                 215                 220                 


Gln Lys Asn Ile Pro Gln Leu Thr Ala Asn Gln Gln Phe Leu Ile Ala 
225                 230                 235                 240 


Arg Leu Ile Trp Tyr Gln Asp Gly Tyr Glu Gln Pro Ser Asp Glu Asp 
                245                 250                 255     


Leu Lys Arg Ile Thr Gln Thr Trp Gln Gln Ala Asp Asp Glu Asn Glu 
            260                 265                 270         


Glu Ser Asp Thr Pro Phe Arg Gln Ile Thr Glu Met Thr Ile Leu Thr 
        275                 280                 285             


Val Gln Leu Ile Val Glu Phe Ala Lys Gly Leu Pro Gly Phe Ala Lys 
    290                 295                 300                 


Ile Ser Gln Pro Asp Gln Ile Thr Leu Leu Lys Ala Cys Ser Ser Glu 
305                 310                 315                 320 


Val Met Met Leu Arg Val Ala Arg Arg Tyr Asp Ala Ala Ser Asp Ser 
                325                 330                 335     


Ile Leu Phe Ala Asn Asn Gln Ala Tyr Thr Arg Asp Asn Tyr Arg Lys 
            340                 345                 350         


Ala Gly Met Ala Glu Val Ile Glu Asp Leu Leu His Phe Cys Arg Cys 
        355                 360                 365             


Met Tyr Ser Met Ala Leu Asp Asn Ile His Tyr Ala Leu Leu Thr Ala 
    370                 375                 380                 


Val Val Ile Phe Ser Asp Arg Pro Gly Leu Glu Gln Pro Gln Leu Val 
385                 390                 395                 400 


Glu Glu Ile Gln Arg Tyr Tyr Leu Asn Thr Leu Arg Ile Tyr Ile Leu 
                405                 410                 415     


Asn Gln Leu Ser Gly Ser Ala Arg Ser Ser Val Ile Tyr Gly Lys Ile 
            420                 425                 430         


Leu Ser Ile Leu Ser Glu Leu Arg Thr Leu Gly Met Gln Asn Ser Asn 
        435                 440                 445             


Met Cys Ile Ser Leu Lys Leu Lys Asn Arg Lys Leu Pro Pro Phe Leu 
    450                 455                 460                 


Glu Glu Ile Trp Asp Val Ala Asp Met Ser His Thr Gln Pro Pro Pro 
465                 470                 475                 480 


Ile Leu Glu Ser Pro Thr Asn Leu 
                485             


<210> 188
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="GAL4-Linker-EcR"

<400> 188
Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Pro Glu Phe Pro Gly Arg Pro Glu Cys Val Val Pro Glu 
145                 150                 155                 160 


Thr Gln Cys Ala Met Lys Arg Lys Glu Lys Lys Ala Gln Lys Glu Lys 
                165                 170                 175     


Asp Lys Leu Pro Val Ser Thr Thr Thr Val Asp Asp His Met Pro Pro 
            180                 185                 190         


Ile Met Gln Cys Glu Pro Pro Pro Pro Glu Ala Ala Arg Ile His Glu 
        195                 200                 205             


Val Val Pro Arg Phe Leu Ser Asp Lys Leu Leu Val Thr Asn Arg Gln 
    210                 215                 220                 


Lys Asn Ile Pro Gln Leu Thr Ala Asn Gln Gln Phe Leu Ile Ala Arg 
225                 230                 235                 240 


Leu Ile Trp Tyr Gln Asp Gly Tyr Glu Gln Pro Ser Asp Glu Asp Leu 
                245                 250                 255     


Lys Arg Ile Thr Gln Thr Trp Gln Gln Ala Asp Asp Glu Asn Glu Glu 
            260                 265                 270         


Ser Asp Thr Pro Phe Arg Gln Ile Thr Glu Met Thr Ile Leu Thr Val 
        275                 280                 285             


Gln Leu Ile Val Glu Phe Ala Lys Gly Leu Pro Gly Phe Ala Lys Ile 
    290                 295                 300                 


Ser Gln Pro Asp Gln Ile Thr Leu Leu Lys Ala Cys Ser Ser Glu Val 
305                 310                 315                 320 


Met Met Leu Arg Val Ala Arg Arg Tyr Asp Ala Ala Ser Asp Ser Ile 
                325                 330                 335     


Leu Phe Ala Asn Asn Gln Ala Tyr Thr Arg Asp Asn Tyr Arg Lys Ala 
            340                 345                 350         


Gly Met Ala Glu Val Ile Glu Asp Leu Leu His Phe Cys Arg Cys Met 
        355                 360                 365             


Tyr Ser Met Ala Leu Asp Asn Ile His Tyr Ala Leu Leu Thr Ala Val 
    370                 375                 380                 


Val Ile Phe Ser Asp Arg Pro Gly Leu Glu Gln Pro Gln Leu Val Glu 
385                 390                 395                 400 


Glu Ile Gln Arg Tyr Tyr Leu Asn Thr Leu Arg Ile Tyr Ile Leu Asn 
                405                 410                 415     


Gln Leu Ser Gly Ser Ala Arg Ser Ser Val Ile Tyr Gly Lys Ile Leu 
            420                 425                 430         


Ser Ile Leu Ser Glu Leu Arg Thr Leu Gly Met Gln Asn Ser Asn Met 
        435                 440                 445             


Cys Ile Ser Leu Lys Leu Lys Asn Arg Lys Leu Pro Pro Phe Leu Glu 
    450                 455                 460                 


Glu Ile Trp Asp Val Ala Asp Met Ser His Thr Gln Pro Pro Pro Ile 
465                 470                 475                 480 


Leu Glu Ser Pro Thr Asn Leu 
                485         


<210> 189
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Truncated EGFR (huEGFRt) (Her1t)"

<400> 189
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210> 190
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 1 (Her1 truncated design 1) 
      (HER1t1)"

<400> 190
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
    210                 215                 220                 


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
225                 230                 235                 240 


Ser Lys Arg Ser 
                


<210> 191
<211> 257
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 2 (Her1 truncated design 2) 
      (HER1t2)"

<400> 191
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
225                 230                 235                 240 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                245                 250                 255     


Ser 
    


<210> 192
<211> 276
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 3 (Her1 truncated design 3) 
      (HER1t3)"

<400> 192
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
                245                 250                 255     


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            260                 265                 270         


Ser Lys Arg Ser 
        275     


<210> 193
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 4 (Her1 truncated design 4) 
      (HER1t4)"

<400> 193
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly 
            260                 265                 270         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        275                 280                 285             


Trp Val Arg Ser Lys Arg Ser 
    290                 295 


<210> 194
<211> 308
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 5 (Her1 truncated design 5) 
      (HER1t5)"

<400> 194
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        275                 280                 285             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    290                 295                 300                 


Ser Lys Arg Ser 
305             


<210> 195
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 6 (Her1 truncated design 6) 
      (HER1t6)"

<400> 195
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly 
    290                 295                 300                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
305                 310                 315                 320 


Phe Trp Val Arg Ser Lys Arg Ser 
                325             


<210> 196
<211> 343
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 7 (Her1 truncated design 7) 
      (HER1t7)"

<400> 196
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Gly Gly Gly Gly Gly Gly Ser Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Arg Ser Lys Arg Ser 
            340             


<210> 197
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 8 (Her1 truncated design 8) 
      (HER1t8)"

<400> 197
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Glu Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly 
    210                 215                 220                 


Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Arg Arg Gly Gly 
225                 230                 235                 240 


Gly Ser 
        


<210> 198
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 9 (Her1 truncated design 9) 
      (HER1t9)"

<400> 198
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val 
    210                 215                 220                 


Ile Gly Thr Ile Leu Leu Ile Ser Tyr Gly Ile Gly Gly Gly Ser 
225                 230                 235                 


<210> 199
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 10 (Her1 truncated design 10) 
      (HER1t10)"

<400> 199
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Ile Thr Leu Ile Ile Phe Gly Val Met Ala Gly Val 
    210                 215                 220                 


Ile Gly Thr Ile Leu Leu Ala Leu Leu Ile Trp Gly Gly Gly Ser 
225                 230                 235                 


<210> 200
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR truncated design 11 (Her1 truncated design 11) 
      (HER1t11)"

<400> 200
Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Gly Ser Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr 
    210                 215                 220                 


Gly Val Ile Leu Thr Ala Leu Phe Leu Gly Gly Gly Ser 
225                 230                 235         


<210> 201
<211> 297
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="FL CD20"

<400> 201
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210> 202
<211> 263
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Truncated CD20 design 1 (CD20t1) [CD20(M1-E263]"

<400> 202
Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu 
            260             


<210> 203
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Interleukin-15"

<400> 203
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 204
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Interleukin-15 receptor alpha"

<400> 204
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val 
65                  70                  75                  80  


Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly 
                85                  90                  95      


Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr 
            100                 105                 110         


Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro 
        115                 120                 125             


Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr 
    130                 135                 140                 


Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser 
145                 150                 155                 160 


His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val 
                165                 170                 175     


Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser 
            180                 185                 190         


Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser 
        195                 200                 205             


Val Glu Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser 
    210                 215                 220                 


Ser Arg Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
225                 230                 235         


<210> 205
<211> 395
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Membrane bound Interleukin-15 with signal peptide"

<400> 205
Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            20                  25                  30          


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        35                  40                  45              


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    50                  55                  60                  


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
65                  70                  75                  80  


Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly 
                85                  90                  95      


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            100                 105                 110         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        115                 120                 125             


Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu Gln Ile Thr 
145                 150                 155                 160 


Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser 
                165                 170                 175     


Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys 
            180                 185                 190         


Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala 
        195                 200                 205             


Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp 
    210                 215                 220                 


Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr 
225                 230                 235                 240 


Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu 
                245                 250                 255     


Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala 
            260                 265                 270         


Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr 
        275                 280                 285             


Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser 
    290                 295                 300                 


Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln 
305                 310                 315                 320 


Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile 
                325                 330                 335     


Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu 
            340                 345                 350         


Ala Cys Tyr Leu Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu 
        355                 360                 365             


Met Glu Ala Met Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg 
    370                 375                 380                 


Asp Glu Asp Leu Glu Asn Cys Ser His His Leu 
385                 390                 395 


<210> 206
<211> 335
<212> PRT
<213> Mus sp.

<220>
<221> source
<223> /note="Murine Interleukin-12 subunit beta (p40)"

<400> 206
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210> 207
<211> 215
<212> PRT
<213> Mus sp.

<220>
<221> source
<223> /note="Murine Interleukin-12 subunit alpha (p35)"

<400> 207
Met Cys Gln Ser Arg Tyr Leu Leu Phe Leu Ala Thr Leu Ala Leu Leu 
1               5                   10                  15      


Asn His Leu Ser Leu Ala Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
            20                  25                  30          


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        35                  40                  45              


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
    50                  55                  60                  


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
65                  70                  75                  80  


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
                85                  90                  95      


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            100                 105                 110         


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        115                 120                 125             


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
    130                 135                 140                 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
145                 150                 155                 160 


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
                165                 170                 175     


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            180                 185                 190         


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
        195                 200                 205             


Met Gly Tyr Leu Ser Ser Ala 
    210                 215 


<210> 208
<211> 535
<212> PRT
<213> Mus sp.

<220>
<221> source
<223> /note="Murine single chain IL-12 (p40-linker-p35)"

<400> 208
Met Cys Pro Gln Lys Leu Thr Ile Ser Trp Phe Ala Ile Val Leu Leu 
1               5                   10                  15      


Val Ser Pro Leu Met Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly 
                325                 330                 335     


Gly Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro Ala Arg 
            340                 345                 350         


Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val 
        355                 360                 365             


Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp 
    370                 375                 380                 


Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr 
385                 390                 395                 400 


Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg 
                405                 410                 415     


Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 
            420                 425                 430         


Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys 
        435                 440                 445             


Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His 
    450                 455                 460                 


Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp 
465                 470                 475                 480 


Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys 
                485                 490                 495     


Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 
            500                 505                 510         


Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 
        515                 520                 525             


Met Gly Tyr Leu Ser Ser Ala 
    530                 535 


<210> 209
<211> 532
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Human single chain IL-12 (p40-linker-p35)"

<400> 209
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         


His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             


Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 


Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 


Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     


Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         


Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             


Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 


Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 


Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     


Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         


His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             


Leu Asn Ala Ser 
    530         


<210> 210
<211> 473
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD19-specific chimeric antigen receptor 
      (CD19-CD8a-CD28-CD3z)"

<400> 210
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn 
305                 310                 315                 320 


Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
                325                 330                 335     


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            340                 345                 350         


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        355                 360                 365             


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    370                 375                 380                 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
385                 390                 395                 400 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                405                 410                 415     


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
            420                 425                 430         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        435                 440                 445             


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
    450                 455                 460                 


Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470             


<210> 211
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="CD19-specific chimeric antigen receptor 
      (CD19-CD8a-CD28-CD3z) with Signal peptide"

<400> 211
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gln Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln 
            100                 105                 110         


Gly Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Thr Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
    130                 135                 140                 


Thr Lys Gly Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala 
145                 150                 155                 160 


Pro Ser Gln Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu 
                165                 170                 175     


Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu 
            180                 185                 190         


Glu Trp Leu Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser 
        195                 200                 205             


Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln 
    210                 215                 220                 


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
225                 230                 235                 240 


Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Lys Pro Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Gly Gly His Ser 
            340                 345                 350         


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210> 212
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-CD19 monoclonal antibody clone FMC63 
      variable heavy chain"

<400> 212
Glu Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Lys His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210> 213
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-CD19 clone FMC63 single chain fragment 
      variable (scFv) with Whitlow linker"

<400> 213
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210> 214
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="hM195 VL"

<400> 214
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210> 215
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="hM195 VH"

<400> 215
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 216
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="hM195 scFv with linker"

<400> 216
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met 
145                 150                 155                 160 


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
                165                 170                 175     


Ile Tyr Pro Tyr Asn Gly Gly Thr Gly Tyr Asn Gln Lys Phe Lys Ser 
            180                 185                 190         


Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu 
        195                 200                 205             


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Gly Arg Pro Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 217
<211> 943
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFR variant III (EGFRvIII)"

<400> 217
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr 
            20                  25                  30          


Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser 
        35                  40                  45              


Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly 
    50                  55                  60                  


Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp 
65                  70                  75                  80  


Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr 
                85                  90                  95      


Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp 
            100                 105                 110         


Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu 
        115                 120                 125             


Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro 
    130                 135                 140                 


Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg 
145                 150                 155                 160 


Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu 
                165                 170                 175     


Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly 
            180                 185                 190         


Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile 
        195                 200                 205             


Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile 
    210                 215                 220                 


Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His 
225                 230                 235                 240 


Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys 
                245                 250                 255     


Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys 
            260                 265                 270         


Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys 
        275                 280                 285             


Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys 
    290                 295                 300                 


Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp 
305                 310                 315                 320 


Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn 
                325                 330                 335     


Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu 
            340                 345                 350         


Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly 
        355                 360                 365             


Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val 
    370                 375                 380                 


Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe 
385                 390                 395                 400 


Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu 
                405                 410                 415     


Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro 
            420                 425                 430         


Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile 
        435                 440                 445             


Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp 
    450                 455                 460                 


Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu 
465                 470                 475                 480 


Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala 
                485                 490                 495     


Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly 
            500                 505                 510         


Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe 
        515                 520                 525             


Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser 
    530                 535                 540                 


Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr 
545                 550                 555                 560 


Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val 
                565                 570                 575     


Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala 
            580                 585                 590         


Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys 
        595                 600                 605             


Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr 
    610                 615                 620                 


Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu 
625                 630                 635                 640 


Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile 
                645                 650                 655     


Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys 
            660                 665                 670         


Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala 
        675                 680                 685             


Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met 
    690                 695                 700                 


Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met 
705                 710                 715                 720 


His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp 
                725                 730                 735     


Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro 
            740                 745                 750         


Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu 
        755                 760                 765             


Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp 
    770                 775                 780                 


Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln 
785                 790                 795                 800 


Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp 
                805                 810                 815     


Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys 
            820                 825                 830         


Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu 
        835                 840                 845             


Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr 
    850                 855                 860                 


Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val 
865                 870                 875                 880 


Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His 
                885                 890                 895     


Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys 
            900                 905                 910         


Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala 
        915                 920                 925             


Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala 
    930                 935                 940             


<210> 218
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone 139 VH"

<400> 218
Glu Val Gln Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Ser Gly Trp Ser Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 219
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone 139 VL"

<400> 219
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 220
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1 VH"

<400> 220
Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 221
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1 VL"

<400> 221
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 222
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1-1 VH"

<400> 222
Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210> 223
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone MR1-1 VL"

<400> 223
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 224
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-1 VH"

<400> 224
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210> 225
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-1 VL"

<400> 225
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 226
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-2 VH"

<400> 226
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Phe Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Ser Pro Tyr Ser Phe Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210> 227
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII Clone humMR1-2 VL"

<400> 227
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 228
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti- EGFRvIII scFv Clone 139"

<400> 228
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
        115                 120                 125             


Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile 
                165                 170                 175     


Ser Gly Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Ser 
    210                 215                 220                 


Ser Gly Trp Ser Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210> 229
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-EGFRvIII scFv clone MR1"

<400> 229
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Ser 
    210                 215                 220                 


Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 230
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti EGFRvIII scFv clone MR1-1"

<400> 230
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 231
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-EGFRvIII scFv clone huMR1-1"

<400> 231
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 232
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="Anti-EGFRvIII scFv clone huMR1-2"

<400> 232
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Phe Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 233
<211> 470
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (clone 139 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 233
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile Val Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Gln 
        115                 120                 125             


Val Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile 
                165                 170                 175     


Ser Gly Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Gly Ser 
    210                 215                 220                 


Ser Gly Trp Ser Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
                245                 250                 255     


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            260                 265                 270         


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        275                 280                 285             


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    290                 295                 300                 


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210> 234
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 234
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Ser 
    210                 215                 220                 


Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210> 235
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 235
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210> 236
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (humMR1-1 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 236
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210> 237
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (humMR1-2 scFv.CD8alpha hinge
      &TM.4-1BB.CD3-zeta)"

<400> 237
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Phe Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210> 238
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha 2x hinge
      &TM.4-1BB.CD3-zeta)"

<400> 238
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
                325                 330                 335     


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
            340                 345                 350         


Ser Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg 
        355                 360                 365             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    370                 375                 380                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
385                 390                 395                 400 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                405                 410                 415     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            420                 425                 430         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        435                 440                 445             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    450                 455                 460                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
465                 470                 475                 480 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                485                 490                 495     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            500                 505                 510         


Gln Ala Leu Pro Pro Arg 
        515             


<210> 239
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha 3x hinge
      &TM.4-1BB.CD3-zeta)"

<400> 239
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
                325                 330                 335     


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            340                 345                 350         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        355                 360                 365             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    370                 375                 380                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
385                 390                 395                 400 


Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys 
                405                 410                 415     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            420                 425                 430         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        435                 440                 445             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    450                 455                 460                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
465                 470                 475                 480 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                485                 490                 495     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            500                 505                 510         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        515                 520                 525             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    530                 535                 540                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
545                 550                 555                 560 


Ala Leu Pro Pro Arg 
                565 


<210> 240
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (MR1-1 scFv.CD8alpha 4x hinge
      &TM.4-1BB.CD3-zeta)"

<400> 240
Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val Ala Thr Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys Phe Leu Ile 
        35                  40                  45              


Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Asp Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Lys Leu Gln Gln 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
                325                 330                 335     


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            340                 345                 350         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
        355                 360                 365             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
    370                 375                 380                 


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
385                 390                 395                 400 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                405                 410                 415     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            420                 425                 430         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        435                 440                 445             


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
    450                 455                 460                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
465                 470                 475                 480 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                485                 490                 495     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            500                 505                 510         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        515                 520                 525             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    530                 535                 540                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
545                 550                 555                 560 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                565                 570                 575     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            580                 585                 590         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        595                 600                 605             


Leu Pro Pro Arg 
    610         


<210> 241
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-1 scFv.CD8alpha 3x hinge 
      & TM.4-1BB.CD3-zeta)"

<400> 241
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
                325                 330                 335     


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            340                 345                 350         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        355                 360                 365             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    370                 375                 380                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
385                 390                 395                 400 


Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys 
                405                 410                 415     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            420                 425                 430         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        435                 440                 445             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    450                 455                 460                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
465                 470                 475                 480 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                485                 490                 495     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            500                 505                 510         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        515                 520                 525             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    530                 535                 540                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
545                 550                 555                 560 


Ala Leu Pro Pro Arg 
                565 


<210> 242
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-1 scFv.CD8alpha 4x hinge 
      & TM.4-1BB.CD3-zeta)"

<400> 242
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
                325                 330                 335     


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            340                 345                 350         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
        355                 360                 365             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
    370                 375                 380                 


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
385                 390                 395                 400 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                405                 410                 415     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            420                 425                 430         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        435                 440                 445             


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
    450                 455                 460                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
465                 470                 475                 480 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                485                 490                 495     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            500                 505                 510         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        515                 520                 525             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    530                 535                 540                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
545                 550                 555                 560 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                565                 570                 575     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            580                 585                 590         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        595                 600                 605             


Leu Pro Pro Arg 
    610         


<210> 243
<211> 565
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-2 scFv.CD8alpha 3x hinge 
      & TM.4-1BB.CD3-zeta)"

<400> 243
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Phe Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
                325                 330                 335     


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            340                 345                 350         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        355                 360                 365             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    370                 375                 380                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
385                 390                 395                 400 


Leu Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys 
                405                 410                 415     


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            420                 425                 430         


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        435                 440                 445             


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    450                 455                 460                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
465                 470                 475                 480 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                485                 490                 495     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            500                 505                 510         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        515                 520                 525             


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
    530                 535                 540                 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
545                 550                 555                 560 


Ala Leu Pro Pro Arg 
                565 


<210> 244
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<220>
<221> source
<223> /note="EGFRvIII CAR (huMR1-2 scFv.CD8alpha 4x hinge 
      & TM.4-1BB.CD3-zeta"

<400> 244
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Met Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Trp Asn Val Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Lys Phe Gly Met Ser Trp Val Arg 
145                 150                 155                 160 


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Thr Gly 
                165                 170                 175     


Gly Tyr Asn Thr Phe Tyr Ser Asp Asn Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
        195                 200                 205             


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Gly Tyr Ser Pro 
    210                 215                 220                 


Tyr Ser Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
    290                 295                 300                 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro 
305                 310                 315                 320 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp 
                325                 330                 335     


Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            340                 345                 350         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
        355                 360                 365             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Ser Asp Lys 
    370                 375                 380                 


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
385                 390                 395                 400 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                405                 410                 415     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            420                 425                 430         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        435                 440                 445             


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Lys Arg Gly Arg Lys Lys 
    450                 455                 460                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
465                 470                 475                 480 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                485                 490                 495     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            500                 505                 510         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        515                 520                 525             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    530                 535                 540                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
545                 550                 555                 560 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                565                 570                 575     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            580                 585                 590         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        595                 600                 605             


Leu Pro Pro Arg 
    610         


