                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Partch, Carrie
       Michael, Alicia
       Fribourgh, Jennifer
       Parico, Gian Carlo
 
<120>  CRY1-CLOCK-BMAL1 COMPLEX-DISRUPTING AGENTS AND METHODS OF USING 
       SAME

<130>  UCSC-360WO

<150>  US 62/444,691
<151>  2017-01-10

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  606
<212>  PRT
<213>  Mus musculus

<400>  1

Met Gly Val Asn Ala Val His Trp Phe Arg Lys Gly Leu Arg Leu His 
1               5                   10                  15      


Asp Asn Pro Ala Leu Lys Glu Cys Ile Gln Gly Ala Asp Thr Ile Arg 
            20                  25                  30          


Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Gly Ser Ser Asn Val Gly 
        35                  40                  45              


Ile Asn Arg Trp Arg Phe Leu Leu Gln Cys Leu Glu Asp Leu Asp Ala 
    50                  55                  60                  


Asn Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Ile Arg Gly Gln Pro 
65                  70                  75                  80  


Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Asn Ile Thr Lys Leu 
                85                  90                  95      


Ser Ile Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg Asp Ala Ala 
            100                 105                 110         


Ile Lys Lys Leu Ala Thr Glu Ala Gly Val Glu Val Ile Val Arg Ile 
        115                 120                 125             


Ser His Thr Leu Tyr Asp Leu Asp Lys Ile Ile Glu Leu Asn Gly Gly 
    130                 135                 140                 


Gln Pro Pro Leu Thr Tyr Lys Arg Phe Gln Thr Leu Val Ser Lys Met 
145                 150                 155                 160 


Glu Pro Leu Glu Met Pro Ala Asp Thr Ile Thr Ser Asp Val Ile Gly 
                165                 170                 175     


Lys Cys Met Thr Pro Leu Ser Asp Asp His Asp Glu Lys Tyr Gly Val 
            180                 185                 190         


Pro Ser Leu Glu Glu Leu Gly Phe Asp Thr Asp Gly Leu Ser Ser Ala 
        195                 200                 205             


Val Trp Pro Gly Gly Glu Thr Glu Ala Leu Thr Arg Leu Glu Arg His 
    210                 215                 220                 


Leu Glu Arg Lys Ala Trp Val Ala Asn Phe Glu Arg Pro Arg Met Asn 
225                 230                 235                 240 


Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly Leu Ser Pro Tyr Leu Arg 
                245                 250                 255     


Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Phe Lys Leu Thr Asp Leu 
            260                 265                 270         


Tyr Lys Lys Val Lys Lys Asn Ser Ser Pro Pro Leu Ser Leu Tyr Gly 
        275                 280                 285             


Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr Ala Ala Thr Asn Asn Pro 
    290                 295                 300                 


Arg Phe Asp Lys Met Glu Gly Asn Pro Ile Cys Val Gln Ile Pro Trp 
305                 310                 315                 320 


Asp Lys Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly Arg Thr Gly 
                325                 330                 335     


Phe Pro Trp Ile Asp Ala Ile Met Thr Gln Leu Arg Gln Glu Gly Trp 
            340                 345                 350         


Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu Thr Arg Gly 
        355                 360                 365             


Asp Leu Trp Ile Ser Trp Glu Glu Gly Met Lys Val Phe Glu Glu Leu 
    370                 375                 380                 


Leu Leu Asp Ala Asp Trp Ser Ile Asn Ala Gly Ser Trp Met Trp Leu 
385                 390                 395                 400 


Ser Cys Ser Ser Phe Phe Gln Gln Phe Phe His Cys Tyr Cys Pro Val 
                405                 410                 415     


Gly Phe Gly Arg Arg Thr Asp Pro Asn Gly Asp Tyr Ile Arg Arg Tyr 
            420                 425                 430         


Leu Pro Val Leu Arg Gly Phe Pro Ala Lys Tyr Ile Tyr Asp Pro Trp 
        435                 440                 445             


Asn Ala Pro Glu Gly Ile Gln Lys Val Ala Lys Cys Leu Ile Gly Val 
    450                 455                 460                 


Asn Tyr Pro Lys Pro Met Val Asn His Ala Glu Ala Ser Arg Leu Asn 
465                 470                 475                 480 


Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg Tyr Arg Gly 
                485                 490                 495     


Leu Gly Leu Leu Ala Ser Val Pro Ser Asn Ser Asn Gly Asn Gly Gly 
            500                 505                 510         


Leu Met Gly Tyr Ala Pro Gly Glu Asn Val Pro Ser Cys Ser Ser Ser 
        515                 520                 525             


Gly Asn Gly Gly Leu Met Gly Tyr Ala Pro Gly Glu Asn Val Pro Ser 
    530                 535                 540                 


Cys Ser Gly Gly Asn Cys Ser Gln Gly Ser Gly Ile Leu His Tyr Ala 
545                 550                 555                 560 


His Gly Asp Ser Gln Gln Thr His Ser Leu Lys Gln Gly Arg Ser Ser 
                565                 570                 575     


Ala Gly Thr Gly Leu Ser Ser Gly Lys Arg Pro Ser Gln Glu Glu Asp 
            580                 585                 590         


Ala Gln Ser Val Gly Pro Lys Val Gln Arg Gln Ser Ser Asn 
        595                 600                 605     


<210>  2
<211>  855
<212>  PRT
<213>  Mus musculus

<400>  2

Met Val Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Thr Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Arg Phe Ile Gly Asn Phe Lys Ser Leu Thr Ser 
    210                 215                 220                 


Val Ser Thr Ser Thr His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Thr Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Thr Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Pro Ser Leu Thr Gln 
                485                 490                 495     


Pro Ala Met Ser Gln Ala Ala Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Asn Ile Gln Gln Leu Thr 
            580                 585                 590         


Pro Val Asn Met Gln Gly Gln Val Val Pro Ala Asn Gln Val Gln Ser 
        595                 600                 605             


Gly His Ile Ser Thr Gly Gln His Met Ile Gln Gln Gln Thr Leu Gln 
    610                 615                 620                 


Ser Thr Ser Thr Gln Gln Ser Gln Gln Ser Val Met Ser Gly His Ser 
625                 630                 635                 640 


Gln Gln Thr Ser Leu Pro Ser Gln Thr Pro Ser Thr Leu Thr Ala Pro 
                645                 650                 655     


Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala Ala Gly Ser Met Val 
            660                 665                 670         


Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr Gln Ser Ala Thr Val 
        675                 680                 685             


Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe Ser Gln Gly Gln Gln 
    690                 695                 700                 


Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala Cys Gly Ala Val Met 
705                 710                 715                 720 


Val Pro Ser Thr Met Leu Met Gly Gln Val Val Thr Ala Tyr Pro Thr 
                725                 730                 735     


Phe Ala Thr Gln Gln Gln Gln Ala Gln Thr Leu Ser Val Thr Gln Gln 
            740                 745                 750         


Gln Gln Gln Gln Gln Gln Gln Pro Pro Gln Gln Gln Gln Gln Gln Gln 
        755                 760                 765             


Gln Ser Ser Gln Glu Gln Gln Leu Pro Ser Val Gln Gln Pro Ala Gln 
    770                 775                 780                 


Ala Gln Leu Gly Gln Pro Pro Gln Gln Phe Leu Gln Thr Ser Arg Leu 
785                 790                 795                 800 


Leu His Gly Asn Pro Ser Thr Gln Leu Ile Leu Ser Ala Ala Phe Pro 
                805                 810                 815     


Leu Gln Gln Ser Thr Phe Pro Pro Ser His His Gln Gln His Gln Pro 
            820                 825                 830         


Gln Gln Gln Gln Gln Leu Pro Arg His Arg Thr Asp Ser Leu Thr Asp 
        835                 840                 845             


Pro Ser Lys Val Gln Pro Gln 
    850                 855 


<210>  3
<211>  632
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Gly Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ala Thr Asp Tyr Gln Leu 
        35                  40                  45              


Asp Asp Phe Ala Phe Glu Glu Ser Met Asp Thr Asp Lys Asp Asp Pro 
    50                  55                  60                  


His Gly Arg Leu Glu Tyr Ala Glu His Gln Gly Arg Ile Lys Asn Ala 
65                  70                  75                  80  


Arg Glu Ala His Ser Gln Ile Glu Lys Arg Arg Arg Asp Lys Met Asn 
                85                  90                  95      


Ser Phe Ile Asp Glu Leu Ala Ser Leu Val Pro Thr Cys Asn Ala Met 
            100                 105                 110         


Ser Arg Lys Leu Asp Lys Leu Thr Val Leu Arg Met Ala Val Gln His 
        115                 120                 125             


Met Lys Thr Leu Arg Gly Ala Thr Asn Pro Tyr Thr Glu Ala Asn Tyr 
    130                 135                 140                 


Lys Pro Thr Phe Leu Ser Asp Asp Glu Leu Lys His Leu Ile Leu Arg 
145                 150                 155                 160 


Ala Ala Asp Gly Phe Leu Phe Val Val Gly Cys Asp Arg Gly Lys Ile 
                165                 170                 175     


Leu Phe Val Ser Glu Ser Val Phe Lys Ile Leu Asn Tyr Ser Gln Asn 
            180                 185                 190         


Asp Leu Ile Gly Gln Ser Leu Phe Asp Tyr Leu His Pro Lys Asp Ile 
        195                 200                 205             


Ala Lys Val Lys Glu Gln Leu Ser Ser Ser Asp Thr Ala Pro Arg Glu 
    210                 215                 220                 


Arg Leu Ile Asp Ala Lys Thr Gly Leu Pro Val Lys Thr Asp Ile Thr 
225                 230                 235                 240 


Pro Gly Pro Ser Arg Leu Cys Ser Gly Ala Arg Arg Ser Phe Phe Cys 
                245                 250                 255     


Arg Met Lys Cys Asn Arg Pro Ser Val Lys Val Glu Asp Lys Asp Phe 
            260                 265                 270         


Ala Ser Thr Cys Ser Lys Lys Lys Asp Arg Lys Ser Phe Cys Thr Ile 
        275                 280                 285             


His Ser Thr Gly Tyr Leu Lys Ser Trp Pro Pro Thr Lys Met Gly Leu 
    290                 295                 300                 


Asp Glu Asp Asn Glu Pro Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu 
305                 310                 315                 320 


Val Ala Ile Gly Arg Leu His Ser His Met Val Pro Gln Pro Ala Asn 
                325                 330                 335     


Gly Glu Ile Arg Val Lys Ser Met Glu Tyr Val Ser Arg His Ala Ile 
            340                 345                 350         


Asp Gly Lys Phe Val Phe Val Asp Gln Arg Ala Thr Ala Ile Leu Ala 
        355                 360                 365             


Tyr Leu Pro Gln Glu Leu Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His 
    370                 375                 380                 


Gln Asp Asp Ile Gly His Leu Ala Glu Cys His Arg Gln Val Leu Gln 
385                 390                 395                 400 


Thr Arg Glu Lys Ile Thr Thr Asn Cys Tyr Lys Phe Lys Ile Lys Asp 
                405                 410                 415     


Gly Ser Phe Ile Thr Leu Arg Ser Arg Trp Phe Ser Phe Met Asn Pro 
            420                 425                 430         


Trp Thr Lys Glu Val Glu Tyr Ile Val Ser Thr Asn Thr Val Val Leu 
        435                 440                 445             


Ala Asn Val Leu Glu Gly Gly Asp Pro Thr Phe Pro Gln Leu Thr Ala 
    450                 455                 460                 


Pro Pro His Ser Met Asp Ser Met Leu Pro Ser Gly Glu Gly Gly Pro 
465                 470                 475                 480 


Lys Arg Thr His Pro Thr Val Pro Gly Ile Pro Gly Gly Thr Arg Ala 
                485                 490                 495     


Gly Ala Gly Lys Ile Gly Arg Met Ile Ala Glu Glu Ile Met Glu Ile 
            500                 505                 510         


His Arg Ile Arg Gly Ser Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu 
        515                 520                 525             


Asn Ile Thr Ser Thr Pro Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys 
    530                 535                 540                 


Lys Ile Leu Asn Gly Gly Thr Pro Asp Ile Pro Ser Thr Gly Leu Leu 
545                 550                 555                 560 


Pro Gly Gln Ala Gln Glu Thr Pro Gly Tyr Pro Tyr Ser Asp Ser Ser 
                565                 570                 575     


Ser Ile Leu Gly Glu Asn Pro His Ile Gly Ile Asp Met Ile Asp Asn 
            580                 585                 590         


Asp Gln Gly Ser Ser Ser Pro Ser Asn Asp Glu Ala Ala Met Ala Val 
        595                 600                 605             


Ile Met Ser Leu Leu Glu Ala Asp Ala Gly Leu Gly Gly Pro Val Asp 
    610                 615                 620                 


Phe Ser Asp Leu Pro Trp Pro Leu 
625                 630         


<210>  4
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Val Asn Ala Val His Trp Phe Arg Lys Gly Leu Arg Leu His 
1               5                   10                  15      


Asp Asn Pro Ala Leu Lys Glu Cys Ile Gln Gly Ala Asp Thr Ile Arg 
            20                  25                  30          


Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Gly Ser Ser Asn Val Gly 
        35                  40                  45              


Ile Asn Arg Trp Arg Phe Leu Leu Gln Cys Leu Glu Asp Leu Asp Ala 
    50                  55                  60                  


Asn Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Ile Arg Gly Gln Pro 
65                  70                  75                  80  


Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Asn Ile Thr Lys Leu 
                85                  90                  95      


Ser Ile Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg Asp Ala Ala 
            100                 105                 110         


Ile Lys Lys Leu Ala Thr Glu Ala Gly Val Glu Val Ile Val Arg Ile 
        115                 120                 125             


Ser His Thr Leu Tyr Asp Leu Asp Lys Ile Ile Glu Leu Asn Gly Gly 
    130                 135                 140                 


Gln Pro Pro Leu Thr Tyr Lys Arg Phe Gln Thr Leu Ile Ser Lys Met 
145                 150                 155                 160 


Glu Pro Leu Glu Ile Pro Val Glu Thr Ile Thr Ser Glu Val Ile Glu 
                165                 170                 175     


Lys Cys Thr Thr Pro Leu Ser Asp Asp His Asp Glu Lys Tyr Gly Val 
            180                 185                 190         


Pro Ser Leu Glu Glu Leu Gly Phe Asp Thr Asp Gly Leu Ser Ser Ala 
        195                 200                 205             


Val Trp Pro Gly Gly Glu Thr Glu Ala Leu Thr Arg Leu Glu Arg His 
    210                 215                 220                 


Leu Glu Arg Lys Ala Trp Val Ala Asn Phe Glu Arg Pro Arg Met Asn 
225                 230                 235                 240 


Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly Leu Ser Pro Tyr Leu Arg 
                245                 250                 255     


Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Phe Lys Leu Thr Asp Leu 
            260                 265                 270         


Tyr Lys Lys Val Lys Lys Asn Ser Ser Pro Pro Leu Ser Leu Tyr Gly 
        275                 280                 285             


Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr Ala Ala Thr Asn Asn Pro 
    290                 295                 300                 


Arg Phe Asp Lys Met Glu Gly Asn Pro Ile Cys Val Gln Ile Pro Trp 
305                 310                 315                 320 


Asp Lys Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly Arg Thr Gly 
                325                 330                 335     


Phe Pro Trp Ile Asp Ala Ile Met Thr Gln Leu Arg Gln Glu Gly Trp 
            340                 345                 350         


Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu Thr Arg Gly 
        355                 360                 365             


Asp Leu Trp Ile Ser Trp Glu Glu Gly Met Lys Val Phe Glu Glu Leu 
    370                 375                 380                 


Leu Leu Asp Ala Asp Trp Ser Ile Asn Ala Gly Ser Trp Met Trp Leu 
385                 390                 395                 400 


Ser Cys Ser Ser Phe Phe Gln Gln Phe Phe His Cys Tyr Cys Pro Val 
                405                 410                 415     


Gly Phe Gly Arg Arg Thr Asp Pro Asn Gly Asp Tyr Ile Arg Arg Tyr 
            420                 425                 430         


Leu Pro Val Leu Arg Gly Phe Pro Ala Lys Tyr Ile Tyr Asp Pro Trp 
        435                 440                 445             


Asn Ala Pro Glu Gly Ile Gln Lys Val Ala Lys Cys Leu Ile Gly Val 
    450                 455                 460                 


Asn Tyr Pro Lys Pro Met Val Asn His Ala Glu Ala Ser Arg Leu Asn 
465                 470                 475                 480 


Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu Ser Arg Tyr Arg Gly 
                485                 490                 495     


Leu Gly Leu Leu Ala Ser Val Pro Ser Asn Pro Asn Gly Asn Gly Gly 
            500                 505                 510         


Phe Met Gly Tyr Ser Ala Glu Asn Ile Pro Gly Cys Ser Ser Ser Gly 
        515                 520                 525             


Ser Cys Ser Gln Gly Ser Gly Ile Leu His Tyr Ala His Gly Asp Ser 
    530                 535                 540                 


Gln Gln Thr His Leu Leu Lys Gln Gly Arg Ser Ser Met Gly Thr Gly 
545                 550                 555                 560 


Leu Ser Gly Gly Lys Arg Pro Ser Gln Glu Glu Asp Thr Gln Ser Ile 
                565                 570                 575     


Gly Pro Lys Val Gln Arg Gln Ser Thr Asn 
            580                 585     


<210>  5
<211>  846
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Ile Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Ile Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Lys Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Ser Ser Ser Ala His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Glu Thr Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Val Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Ile Asn Ser Gln Ser Val Gly Ser Ser Leu Thr Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Thr Asn Leu Pro Ile Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Ala Pro Ile Asn Met Gln Gly Gln Val Val Pro Thr Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Thr Gly His Ile Gly Thr Thr Gln His Met Ile Gln 
    610                 615                 620                 


Gln Gln Thr Leu Gln Ser Thr Ser Thr Gln Ser Gln Gln Asn Val Leu 
625                 630                 635                 640 


Ser Gly His Ser Gln Gln Thr Ser Leu Pro Ser Gln Thr Gln Ser Thr 
                645                 650                 655     


Leu Thr Ala Pro Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala Ala 
            660                 665                 670         


Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr Gln 
        675                 680                 685             


Ser Ala Ala Val Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe Ser 
    690                 695                 700                 


Gln Gly Gln Gln Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala Cys 
705                 710                 715                 720 


Gly Ala Val Met Val Pro Ser Thr Met Leu Met Gly Gln Val Val Thr 
                725                 730                 735     


Ala Tyr Pro Thr Phe Ala Thr Gln Gln Gln Gln Ser Gln Thr Leu Ser 
            740                 745                 750         


Val Thr Gln Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln Gln Leu Thr 
        755                 760                 765             


Ser Val Gln Gln Pro Ser Gln Ala Gln Leu Thr Gln Pro Pro Gln Gln 
    770                 775                 780                 


Phe Leu Gln Thr Ser Arg Leu Leu His Gly Asn Pro Ser Thr Gln Leu 
785                 790                 795                 800 


Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Thr Phe Pro Gln Ser 
                805                 810                 815     


His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu Ser Arg His 
            820                 825                 830         


Arg Thr Asp Ser Leu Pro Asp Pro Ser Lys Val Gln Pro Gln 
        835                 840                 845     


<210>  6
<211>  626
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Asp Gln Arg Met Asp Ile Ser Ser Thr Ile Ser Asp Phe Met 
1               5                   10                  15      


Ser Pro Gly Pro Thr Asp Leu Leu Ser Ser Ser Leu Gly Thr Ser Gly 
            20                  25                  30          


Val Asp Cys Asn Arg Lys Arg Lys Gly Ser Ser Thr Asp Tyr Gln Glu 
        35                  40                  45              


Ser Met Asp Thr Asp Lys Asp Asp Pro His Gly Arg Leu Glu Tyr Thr 
    50                  55                  60                  


Glu His Gln Gly Arg Ile Lys Asn Ala Arg Glu Ala His Ser Gln Ile 
65                  70                  75                  80  


Glu Lys Arg Arg Arg Asp Lys Met Asn Ser Phe Ile Asp Glu Leu Ala 
                85                  90                  95      


Ser Leu Val Pro Thr Cys Asn Ala Met Ser Arg Lys Leu Asp Lys Leu 
            100                 105                 110         


Thr Val Leu Arg Met Ala Val Gln His Met Lys Thr Leu Arg Gly Ala 
        115                 120                 125             


Thr Asn Pro Tyr Thr Glu Ala Asn Tyr Lys Pro Thr Phe Leu Ser Asp 
    130                 135                 140                 


Asp Glu Leu Lys His Leu Ile Leu Arg Ala Ala Asp Gly Phe Leu Phe 
145                 150                 155                 160 


Val Val Gly Cys Asp Arg Gly Lys Ile Leu Phe Val Ser Glu Ser Val 
                165                 170                 175     


Phe Lys Ile Leu Asn Tyr Ser Gln Asn Asp Leu Ile Gly Gln Ser Leu 
            180                 185                 190         


Phe Asp Tyr Leu His Pro Lys Asp Ile Ala Lys Val Lys Glu Gln Leu 
        195                 200                 205             


Ser Ser Ser Asp Thr Ala Pro Arg Glu Arg Leu Ile Asp Ala Lys Thr 
    210                 215                 220                 


Gly Leu Pro Val Lys Thr Asp Ile Thr Pro Gly Pro Ser Arg Leu Cys 
225                 230                 235                 240 


Ser Gly Ala Arg Arg Ser Phe Phe Cys Arg Met Lys Cys Asn Arg Pro 
                245                 250                 255     


Ser Val Lys Val Glu Asp Lys Asp Phe Pro Ser Thr Cys Ser Lys Lys 
            260                 265                 270         


Lys Ala Asp Arg Lys Ser Phe Cys Thr Ile His Ser Thr Gly Tyr Leu 
        275                 280                 285             


Lys Ser Trp Pro Pro Thr Lys Met Gly Leu Asp Glu Asp Asn Glu Pro 
    290                 295                 300                 


Asp Asn Glu Gly Cys Asn Leu Ser Cys Leu Val Ala Ile Gly Arg Leu 
305                 310                 315                 320 


His Ser His Val Val Pro Gln Pro Val Asn Gly Glu Ile Arg Val Lys 
                325                 330                 335     


Ser Met Glu Tyr Val Ser Arg His Ala Ile Asp Gly Lys Phe Val Phe 
            340                 345                 350         


Val Asp Gln Arg Ala Thr Ala Ile Leu Ala Tyr Leu Pro Gln Glu Leu 
        355                 360                 365             


Leu Gly Thr Ser Cys Tyr Glu Tyr Phe His Gln Asp Asp Ile Gly His 
    370                 375                 380                 


Leu Ala Glu Cys His Arg Gln Val Leu Gln Thr Arg Glu Lys Ile Thr 
385                 390                 395                 400 


Thr Asn Cys Tyr Lys Phe Lys Ile Lys Asp Gly Ser Phe Ile Thr Leu 
                405                 410                 415     


Arg Ser Arg Trp Phe Ser Phe Met Asn Pro Trp Thr Lys Glu Val Glu 
            420                 425                 430         


Tyr Ile Val Ser Thr Asn Thr Val Val Leu Ala Asn Val Leu Glu Gly 
        435                 440                 445             


Gly Asp Pro Thr Phe Pro Gln Leu Thr Ala Ser Pro His Ser Met Asp 
    450                 455                 460                 


Ser Met Leu Pro Ser Gly Glu Gly Gly Pro Lys Arg Thr His Pro Thr 
465                 470                 475                 480 


Val Pro Gly Ile Pro Gly Gly Thr Arg Ala Gly Ala Gly Lys Ile Gly 
                485                 490                 495     


Arg Met Ile Ala Glu Glu Ile Met Glu Ile His Arg Ile Arg Gly Ser 
            500                 505                 510         


Ser Pro Ser Ser Cys Gly Ser Ser Pro Leu Asn Ile Thr Ser Thr Pro 
        515                 520                 525             


Pro Pro Asp Ala Ser Ser Pro Gly Gly Lys Lys Ile Leu Asn Gly Gly 
    530                 535                 540                 


Thr Pro Asp Ile Pro Ser Ser Gly Leu Leu Ser Gly Gln Ala Gln Glu 
545                 550                 555                 560 


Asn Pro Gly Tyr Pro Tyr Ser Asp Ser Ser Ser Ile Leu Gly Glu Asn 
                565                 570                 575     


Pro His Ile Gly Ile Asp Met Ile Asp Asn Asp Gln Gly Ser Ser Ser 
            580                 585                 590         


Pro Ser Asn Asp Glu Ala Ala Met Ala Val Ile Met Ser Leu Leu Glu 
        595                 600                 605             


Ala Asp Ala Gly Leu Gly Gly Pro Val Asp Phe Ser Asp Leu Pro Trp 
    610                 615                 620                 


Pro Leu 
625     


<210>  7
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Val Asn Ala Val His Trp Phe Arg Lys Gly Leu Arg Leu His 
1               5                   10                  15      


Asp Asn Pro Ala Leu Lys Glu Cys Ile Gln Gly Ala Asp Thr Ile Arg 
            20                  25                  30          


Cys Val Tyr Ile Leu Asp Pro Trp Phe Ala Gly Ser Ser Asn Val Gly 
        35                  40                  45              


Ile Asn Arg Trp Arg Phe Leu Leu Gln Cys Leu Glu Asp Leu Asp Ala 
    50                  55                  60                  


Asn Leu Arg Lys Leu Asn Ser Arg Leu Phe Val Ile Arg Gly Gln Pro 
65                  70                  75                  80  


Ala Asp Val Phe Pro Arg Leu Phe Lys Glu Trp Asn Ile Thr Lys Leu 
                85                  90                  95      


Ser Ile Glu Tyr Asp Ser Glu Pro Phe Gly Lys Glu Arg Asp Ala Ala 
            100                 105                 110         


Ile Lys Lys Leu Ala Thr Glu Ala Gly Val Glu Val Ile Val Arg Ile 
        115                 120                 125             


Ser His Thr Leu Tyr Asp Leu Asp Lys Ile Ile Glu Leu Asn Gly Gly 
    130                 135                 140                 


Gln Pro Pro Leu Thr Tyr Lys Arg Phe Gln Thr Leu Val Ser Lys Met 
145                 150                 155                 160 


Glu Pro Leu Glu Met Pro Ala Asp Thr Ile Thr Ser Asp Val Ile Gly 
                165                 170                 175     


Lys Cys Met Thr Pro Leu Ser Asp Asp His Asp Glu Lys Tyr Gly Val 
            180                 185                 190         


Pro Ser Leu Glu Glu Leu Gly Phe Asp Thr Asp Gly Leu Ser Ser Ala 
        195                 200                 205             


Val Trp Pro Gly Gly Glu Thr Glu Ala Leu Thr Arg Leu Glu Arg His 
    210                 215                 220                 


Leu Glu Arg Lys Ala Trp Val Ala Asn Phe Glu Arg Pro Arg Met Asn 
225                 230                 235                 240 


Ala Asn Ser Leu Leu Ala Ser Pro Thr Gly Leu Ser Pro Tyr Leu Arg 
                245                 250                 255     


Phe Gly Cys Leu Ser Cys Arg Leu Phe Tyr Phe Lys Leu Thr Asp Leu 
            260                 265                 270         


Tyr Lys Lys Val Lys Lys Asn Ser Ser Pro Pro Leu Ser Leu Tyr Gly 
        275                 280                 285             


Gln Leu Leu Trp Arg Glu Phe Phe Tyr Thr Ala Ala Thr Asn Asn Pro 
    290                 295                 300                 


Arg Phe Asp Lys Met Glu Gly Asn Pro Ile Cys Val Gln Ile Pro Trp 
305                 310                 315                 320 


Asp Lys Asn Pro Glu Ala Leu Ala Lys Trp Ala Glu Gly Arg Thr Gly 
                325                 330                 335     


Phe Pro Trp Ile Asp Ala Ile Met Thr Gln Leu Arg Gln Glu Gly Trp 
            340                 345                 350         


Ile His His Leu Ala Arg His Ala Val Ala Cys Phe Leu Thr Arg Gly 
        355                 360                 365             


Asp Leu Trp Ile Ser Trp Glu Glu Gly Met Lys Val Phe Glu Glu Leu 
    370                 375                 380                 


Leu Leu Asp Ala Asp Trp Ser Ile Asn Ala Gly Ser Trp Met Trp Leu 
385                 390                 395                 400 


Ser Cys Ser Ser Phe Phe Gln Gln Phe Phe His Cys Tyr Cys Pro Val 
                405                 410                 415     


Gly Phe Gly Arg Arg Thr Asp Pro Asn Gly Asp Tyr Ile Arg Arg Tyr 
            420                 425                 430         


Leu Pro Val Leu Arg Gly Phe Pro Ala Lys Tyr Ile Tyr Asp Pro Trp 
        435                 440                 445             


Asn Ala Pro Glu Gly Ile Gln Lys Val Ala Lys Cys Leu Ile Gly Val 
    450                 455                 460                 


Asn Tyr Pro Lys Pro Met Val Asn His Ala Glu Ala Ser Arg Leu Asn 
465                 470                 475                 480 


Ile Glu Arg Met Lys Gln Ile Tyr Gln Gln Leu 
                485                 490     


<210>  8
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide sequence

<400>  8

Gly Ala Met Asp Pro Glu Phe Met Gly Val Asn Ala Val His Trp Phe 
1               5                   10                  15      


Arg Lys Gly Leu Arg Leu His Asp Asn Pro Ala Leu Lys Glu Cys Ile 
            20                  25                  30          


Gln Gly Ala Asp Thr Ile Arg Cys Val Tyr Ile Leu Asp Pro Trp Phe 
        35                  40                  45              


Ala Gly Ser Ser Asn Val Gly Ile Asn Arg Trp Arg Phe Leu Leu Gln 
    50                  55                  60                  


Cys Leu Glu Asp Leu Asp Ala Asn Leu Arg Lys Leu Asn Ser Arg Leu 
65                  70                  75                  80  


Phe Val Ile Arg Gly Gln Pro Ala Asp Val Phe Pro Arg Leu Phe Lys 
                85                  90                  95      


Glu Trp Asn Ile Thr Lys Leu Ser Ile Glu Tyr Asp Ser Glu Pro Phe 
            100                 105                 110         


Gly Lys Glu Arg Asp Ala Ala Ile Lys Lys Leu Ala Thr Glu Ala Gly 
        115                 120                 125             


Val Glu Val Ile Val Arg Ile Ser His Thr Leu Tyr Asp Leu Asp Lys 
    130                 135                 140                 


Ile Ile Glu Leu Asn Gly Gly Gln Pro Pro Leu Thr Tyr Lys Arg Phe 
145                 150                 155                 160 


Gln Thr Leu Val Ser Lys Met Glu Pro Leu Glu Met Pro Ala Asp Thr 
                165                 170                 175     


Ile Thr Ser Asp Val Ile Gly Lys Cys Met Thr Pro Leu Ser Asp Asp 
            180                 185                 190         


His Asp Glu Lys Tyr Gly Val Pro Ser Leu Glu Glu Leu Gly Phe Asp 
        195                 200                 205             


Thr Asp Gly Leu Ser Ser Ala Val Trp Pro Gly Gly Glu Thr Glu Ala 
    210                 215                 220                 


Leu Thr Arg Leu Glu Arg His Leu Glu Arg Lys Ala Trp Val Ala Asn 
225                 230                 235                 240 


Phe Glu Arg Pro Arg Met Asn Ala Asn Ser Leu Leu Ala Ser Pro Thr 
                245                 250                 255     


Gly Leu Ser Pro Tyr Leu Arg Phe Gly Cys Leu Ser Cys Arg Leu Phe 
            260                 265                 270         


Tyr Phe Lys Leu Thr Asp Leu Tyr Lys Lys Val Lys Lys Asn Ser Ser 
        275                 280                 285             


Pro Pro Leu Ser Leu Tyr Gly Gln Leu Leu Trp Arg Glu Phe Phe Tyr 
    290                 295                 300                 


Thr Ala Ala Thr Asn Asn Pro Arg Phe Asp Lys Met Glu Gly Asn Pro 
305                 310                 315                 320 


Ile Cys Val Gln Ile Pro Trp Asp Lys Asn Pro Glu Ala Leu Ala Lys 
                325                 330                 335     


Trp Ala Glu Gly Arg Thr Gly Phe Pro Trp Ile Asp Ala Ile Met Thr 
            340                 345                 350         


Gln Leu Arg Gln Glu Gly Trp Ile His His Leu Ala Arg His Ala Val 
        355                 360                 365             


Ala Cys Phe Leu Thr Arg Gly Asp Leu Trp Ile Ser Trp Glu Glu Gly 
    370                 375                 380                 


Met Lys Val Phe Glu Glu Leu Leu Leu Asp Ala Asp Trp Ser Ile Asn 
385                 390                 395                 400 


Ala Gly Ser Trp Met Trp Leu Ser Cys Ser Ser Phe Phe Gln Gln Phe 
                405                 410                 415     


Phe His Cys Tyr Cys Pro Val Gly Phe Gly Arg Arg Thr Asp Pro Asn 
            420                 425                 430         


Gly Asp Tyr Ile Arg Arg Tyr Leu Pro Val Leu Arg Gly Phe Pro Ala 
        435                 440                 445             


Lys Tyr Ile Tyr Asp Pro Trp Asn Ala Pro Glu Gly Ile Gln Lys Val 
    450                 455                 460                 


Ala Lys Cys Leu Ile Gly Val Asn Tyr Pro Lys Pro Met Val Asn His 
465                 470                 475                 480 


Ala Glu Ala Ser Arg Leu Asn Ile Glu Arg Met Lys Gln Ile Tyr Gln 
                485                 490                 495     


Gln Leu 
        


<210>  9
<211>  540
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide sequence

<400>  9

Met Gly Ser Ser His His His His His His Gly Ser Ser Gly Ser Ser 
1               5                   10                  15      


Gly His His His Gly Ser Ser Gly Ser Ser Gly Ser Ser Met Asn Lys 
            20                  25                  30          


Glu Ile Leu Ala Val Val Glu Ala Val Ser Asn Glu Lys Ala Leu Pro 
        35                  40                  45              


Arg Glu Lys Ile Phe Glu Ala Leu Glu Ser Ala Leu Ala Thr Ala Thr 
    50                  55                  60                  


Lys Lys Lys Tyr Glu Gln Glu Ile Asp Val Arg Val Gln Ile Asp Arg 
65                  70                  75                  80  


Lys Ser Gly Asp Phe Asp Thr Phe Arg Arg Trp Leu Val Val Asp Glu 
                85                  90                  95      


Val Thr Gln Pro Thr Lys Glu Ile Thr Leu Glu Ala Ala Arg Tyr Glu 
            100                 105                 110         


Asp Glu Ser Leu Asn Leu Gly Asp Tyr Val Glu Asp Gln Ile Glu Ser 
        115                 120                 125             


Val Thr Phe Asp Arg Ile Thr Thr Gln Thr Ala Lys Gln Val Ile Val 
    130                 135                 140                 


Gln Lys Val Arg Glu Ala Glu Arg Ala Met Val Val Asp Gln Phe Arg 
145                 150                 155                 160 


Glu His Glu Gly Glu Ile Ile Thr Gly Val Val Lys Lys Val Asn Arg 
                165                 170                 175     


Asp Asn Ile Ser Leu Asp Leu Gly Asn Asn Ala Glu Ala Val Ile Leu 
            180                 185                 190         


Arg Glu Asp Met Leu Pro Arg Glu Asn Phe Arg Pro Gly Asp Arg Val 
        195                 200                 205             


Arg Gly Val Leu Tyr Ser Val Arg Pro Glu Ala Arg Gly Ala Gln Leu 
    210                 215                 220                 


Phe Val Thr Arg Ser Lys Pro Glu Met Leu Ile Glu Leu Phe Arg Ile 
225                 230                 235                 240 


Glu Val Pro Glu Ile Gly Glu Glu Val Ile Glu Ile Lys Ala Ala Ala 
                245                 250                 255     


Arg Asp Pro Gly Ser Arg Ala Lys Ile Ala Val Lys Thr Asn Asp Lys 
            260                 265                 270         


Arg Ile Asp Pro Val Gly Ala Cys Val Gly Met Arg Gly Ala Arg Val 
        275                 280                 285             


Gln Ala Val Ser Thr Glu Leu Gly Gly Glu Arg Ile Asp Ile Val Leu 
    290                 295                 300                 


Trp Asp Asp Asn Pro Ala Gln Phe Val Ile Asn Ala Met Ala Pro Ala 
305                 310                 315                 320 


Asp Val Ala Ser Ile Val Val Asp Glu Asp Lys His Thr Met Asp Ile 
                325                 330                 335     


Ala Val Glu Ala Gly Asn Leu Ala Gln Ala Ile Gly Arg Asn Gly Gln 
            340                 345                 350         


Asn Val Arg Leu Ala Ser Gln Leu Ser Gly Trp Glu Leu Asn Val Met 
        355                 360                 365             


Thr Val Asp Asp Leu Gln Ala Lys His Gln Ala Glu Ala His Ala Ala 
    370                 375                 380                 


Ile Asp Thr Phe Thr Lys Tyr Leu Asp Ile Asp Glu Asp Phe Ala Thr 
385                 390                 395                 400 


Val Leu Val Glu Glu Gly Phe Ser Thr Leu Glu Glu Leu Ala Tyr Val 
                405                 410                 415     


Pro Met Lys Glu Leu Leu Glu Ile Glu Gly Leu Asp Glu Pro Thr Val 
            420                 425                 430         


Glu Ala Leu Arg Glu Arg Ala Lys Asn Ala Leu Ala Thr Ile Ala Gln 
        435                 440                 445             


Ala Gln Glu Glu Ser Leu Gly Asp Asn Lys Pro Ala Asp Asp Leu Leu 
    450                 455                 460                 


Asn Leu Glu Gly Val Asp Arg Asp Leu Ala Phe Lys Leu Ala Ala Arg 
465                 470                 475                 480 


Gly Val Cys Thr Leu Glu Asp Leu Ala Glu Gln Gly Ile Asp Asp Leu 
                485                 490                 495     


Ala Asp Ile Glu Gly Leu Thr Asp Glu Lys Ala Gly Ala Leu Ile Met 
            500                 505                 510         


Ala Ala Arg Asn Ile Cys Trp Phe Gly Asp Glu Ala Gly Ile Glu Glu 
        515                 520                 525             


Asn Leu Tyr Phe Gln Gly Ala Met Asp Pro Glu Phe 
    530                 535                 540 


<210>  10
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro Asn Glu Glu Phe 
1               5                   10                  15      


Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe Leu Asp His Arg 
            20                  25                  30          


Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val Leu Gly Thr Ser 
        35                  40                  45              


Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn Leu Ala Lys Cys 
    50                  55                  60                  


His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser Cys Tyr Tyr Arg 
65                  70                  75                  80  


Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln Thr His Tyr Tyr 
                85                  90                  95      


Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe Ile Val Cys Thr 
            100                 105                 110         


His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu Arg Arg Arg Glu 
        115                 120                 125             


Leu Gly Ile Glu Glu Ser Leu 
    130                 135 


<210>  11
<211>  142
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide sequence

<400>  11

Gly Ala Met Asp Pro Glu Phe Gln Phe Ile Lys Glu Met Cys Thr Val 
1               5                   10                  15      


Glu Glu Pro Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys 
            20                  25                  30          


Phe Leu Phe Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro 
        35                  40                  45              


Phe Glu Val Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp 
    50                  55                  60                  


Leu Glu Asn Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys 
65                  70                  75                  80  


Gly Lys Ser Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile 
                85                  90                  95      


Trp Leu Gln Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg 
            100                 105                 110         


Pro Glu Phe Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val 
        115                 120                 125             


Arg Ala Glu Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu 
    130                 135                 140         


<210>  12
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Ser Gln Gly Ser Gly Ile Leu His Tyr Ala His Gly Asp Ser Gln 
1               5                   10                  15      


Gln Thr His Leu Leu Lys 
            20          


<210>  13
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide sequence

<400>  13

His Gln Trp Asn Ser Arg 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide sequence

<400>  14

Asn Pro Trp Thr Lys Glu 
1               5       


