                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  PBRM1 Biomarkers Predictive Of Anti-Immune Checkpoint Response

<130>  DFS-178.25

<140>  PCT/US2018/012209
<141>  2018-01-03

<150>  US 62/445,094
<151>  2017-01-11

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  7592
<212>  DNA
<213>  Homo sapiens

<400>  1
gcggccgcgg ccggaggagc aatagcagca gccgtggcgg ccacggggcg gggcgcggcg       60

gtcggtgacc gcggccgggg ctgcaggcgg cggagcggct ggaagttgga ttccatgggt      120

tccaagagaa gaagagctac ctccccttcc agcagtgtca gcggggactt tgatgatggg      180

caccattctg tgtcaacacc aggcccaagc aggaaaagga ggagactttc caatcttcca      240

actgtagatc ctattgccgt gtgccatgaa ctctataata ccatccgaga ctataaggat      300

gaacagggca gacttctctg tgagctcttc attagggcac caaagcgaag aaatcaacca      360

gactattatg aagtggtttc tcagcccatt gacttgatga aaatccaaca gaaactaaaa      420

atggaagagt atgatgatgt taatttgctg actgctgact tccagcttct ttttaacaat      480

gcaaagtcct attataagcc agattctcct gaatataaag ccgcttgcaa actctgggat      540

ttgtaccttc gaacaagaaa tgagtttgtt cagaaaggag aagcagatga cgaagatgat      600

gatgaagatg ggcaagacaa tcagggcaca gtgactgaag gatcttctcc agcttacttg      660

aaggagatcc tggagcagct tcttgaagcc atagttgtag ctacaaatcc atcaggacgt      720

ctcattagcg aactttttca gaaactgcct tctaaagtgc aatatccaga ttattatgca      780

ataattaagg agcctataga tctcaagacc attgcccaga ggatacagaa tggaagctac      840

aaaagtattc atgcaatggc caaagatata gatctcctcg caaaaaatgc caaaacttat      900

aatgagcctg gctctcaagt attcaaggat gcaaattcaa ttaaaaaaat attttatatg      960

aaaaaggctg aaattgaaca tcatgaaatg gctaagtcaa gtcttcgaat gaggactcca     1020

tccaacttgg ctgcagccag actgacaggt ccttcacaca gtaaaggcag ccttggtgaa     1080

gagagaaatc ccactagcaa gtattaccgt aataaaagag cagtacaagg aggtcgttta     1140

tcagcaatta caatggcact tcaatatggc tcagaaagtg aagaagatgc tgctttagct     1200

gctgcacgct atgaagaggg agagtcagaa gcagaaagca tcacttcctt tatggatgtt     1260

tcaaatcctt tttatcagct ttatgacaca gttaggagtt gtcggaataa ccaagggcag     1320

ctaatagctg aaccttttta ccatttgcct tcaaagaaaa aataccctga ttattaccag     1380

caaattaaaa tgcccatatc actacaacag atccgaacaa aactgaagaa tcaagaatat     1440

gaaactttag atcatttgga gtgtgatctg aatttaatgt ttgaaaatgc caaacgctat     1500

aatgtgccca attcagccat ctacaagcga gttctaaaat tgcagcaagt tatgcaggca     1560

aagaagaaag agcttgccag gagagacgat atcgaggacg gagacagcat gatctcttca     1620

gccacctctg atactggtag tgccaaaaga aaaagtaaaa agaacataag aaagcagcga     1680

atgaaaatct tattcaatgt tgttcttgaa gctcgagagc caggttcagg cagaagactt     1740

tgtgacctat ttatggttaa accatccaaa aaggactatc ctgattatta taaaatcatc     1800

ttggagccaa tggacttgaa aataattgag cataacatcc gcaatgacaa atatgctggt     1860

gaagagggaa tgatagaaga catgaagctg atgttccgga atgccaggca ctataatgag     1920

gagggctccc aggtttataa tgatgcacat atcctggaga agttactcaa ggagaaaagg     1980

aaagagctgg gcccactgcc tgatgatgat gacatggctt ctcccaaact caagctgagt     2040

aggaagagtg gcatttctcc taaaaaatca aaatacatga ctccaatgca gcagaaacta     2100

aatgaggtct atgaagctgt aaagaactat actgataaga ggggtcgccg cctcagtgcc     2160

atatttctga ggcttccctc tagatctgag ttgcctgact actatctgac tattaaaaag     2220

cccatggaca tggaaaaaat tcgaagtcac atgatggcca acaagtacca agatattgac     2280

tctatggttg aggactttgt catgatgttt aataatgcct gtacatacaa tgagccggag     2340

tctttgatct acaaagatgc tcttgttcta cacaaagtcc tgcttgaaac acgcagagac     2400

ctggagggag atgaggactc tcatgtccca aatgtgactt tgctgattca agagcttatc     2460

cacaatcttt ttgtgtcagt catgagtcat caggatgatg agggaagatg ctacagcgat     2520

tctttagcag aaattcctgc tgtggatccc aactttccta acaaaccacc ccttacattt     2580

gacataatta ggaagaatgt tgaaaataat cgctaccgtc ggcttgattt atttcaagag     2640

catatgtttg aagtattgga acgagcaaga aggatgaatc ggacagattc agaaatatat     2700

gaagatgcag tagaacttca gcagtttttt attaaaattc gtgatgaact ctgcaaaaat     2760

ggagagattc ttctttcacc ggcactcagc tataccacaa aacatttgca taatgatgtg     2820

gagaaagaga gaaaggaaaa attgccaaaa gaaatagagg aagataaact aaaacgagaa     2880

gaagaaaaaa gagaagctga aaagagtgaa gattcctctg gtgctgcagg cctctcaggc     2940

ttacatcgca catacagcca ggactgtagc tttaaaaaca gcatgtacca tgttggagat     3000

tacgtctatg tggaacctgc agaggccaac ctacaaccac atatcgtctg tattgaaaga     3060

ctgtgggagg attcagctga aaaagaagtt tttaagagtg actattacaa caaagttcca     3120

gttagtaaaa ttctaggcaa gtgtgtggtc atgtttgtca aggaatactt taagttatgc     3180

ccagaaaact tccgagatga ggatgttttt gtctgtgaat cacggtattc tgccaaaacc     3240

aaatctttta agaaaattaa actgtggacc atgcccatca gctcagtcag gtttgtccct     3300

cgggatgtgc ctctgcctgt ggttcgcgtg gcctctgtat ttgcaaatgc agataaaggt     3360

gatgatgaga agaatacaga caactcagag gacagtcgag ctgaagacaa ttttaacttg     3420

gaaaaggaaa aagaagatgt ccctgtggaa atgtccaatg gtgaaccagg ttgccactac     3480

tttgagcagc tccattacaa tgacatgtgg ctgaaggttg gcgactgtgt cttcatcaag     3540

tcccatggcc tggtgcgtcc tcgtgtgggc agaattgaaa aagtatgggt tcgagatgga     3600

gctgcatatt tttatggccc catcttcatt cacccagaag aaacagagca tgagcccaca     3660

aaaatgttct acaaaaaaga agtatttctg agtaatctgg aagaaacctg ccccatgaca     3720

tgtattctcg gaaagtgtgc tgtgttgtca ttcaaggact tcctctcctg caggccaact     3780

gaaataccag aaaatgacat tctgctttgt gagagccgct acaatgagag cgacaagcag     3840

atgaagaaat tcaaaggatt gaagaggttt tcactctctg ctaaagtggt agatgatgaa     3900

atttactact tcagaaaacc aattgttcct cagaaggagc catcaccttt gctggaaaag     3960

aagatccagt tgctagaagc taaatttgcc gagttagaag gtggagatga tgatattgaa     4020

gagatgggag aagaagatag tgagtctacc ccaaagtctg ccaaaggcag tgcaaagaag     4080

gaaggctcca aacggaaaat caacatgagt ggctacatcc tgttcagcag tgagatgagg     4140

gctgtgatta aggcccaaca cccagactac tctttcgggg agctcagccg cctggtgggg     4200

acagaatgga gaaatcttga gacagccaag aaagcagaat atgaaggcat gatgggtggc     4260

tatccgccag gccttccacc tttgcagggc ccagttgatg gccttgttag catgggcagc     4320

atgcagccac ttcaccctgg ggggcctcca ccccaccatc ttccgccagg tgtgcctggc     4380

ctcccgggca tcccaccacc gggtgtgatg aaccaaggag tggcccctat ggtagggact     4440

ccagcaccag gtggaagtcc atatggacaa caggtgggag ttttggggcc tccagggcag     4500

caggcaccac ctccatatcc cggcccacat ccagctggac cccctgtcat acagcagcca     4560

acaacaccca tgtttgtagc tcccccacca aagacccagc ggcttcttca ctcagaggcc     4620

tacctgaaat acattgaagg actcagtgcg gagtccaaca gcattagcaa gtgggatcag     4680

acactggcag ctcgaagacg cgacgtccat ttgtcgaaag aacaggagag ccgcctaccc     4740

tctcactggc tgaaaagcaa aggggcccac accaccatgg cagatgccct ctggcgcctt     4800

cgagatttga tgctccggga caccctcaac attcgccaag catacaacct agaaaatgtt     4860

taatcacatc attacgtttc ttttatatag aagcataaag agttgtggat cagtagccat     4920

tttagttact gggggtgggg ggaaggaaca aaggaggata atttttattg cattttactg     4980

tacatcacaa ggccattttt atatacggac acttttaata agctatttca atttgtttgt     5040

tatattaagt tgactttatc aaatacacaa agattttttt gcatatgttt ccttcgttta     5100

aaaccagttt cataattggt tgtatatgta gacttggagt tttatctttt tacttgttgc     5160

catggaactg aaaccattag aggtttttgt cttggcttgg ggtttttgtt ttcttggttt     5220

tgggtttttt tatatatata tataaaagaa caaaatgaaa aaaaacacac acacacaaga     5280

gtttacagat tagtttaaat tgataatgaa atgtgaagtt tgtcctagtt tacatcttag     5340

agaggggagt atacttgtgt ttgtttcatg tgcctgaata tcttaagcca ctttctgcaa     5400

aagctgtttc ttacagatga agtgctttct ttgaaaggtg gttatttagg ttttagatgt     5460

ttaatagaca cagcacattt gctctattaa ctcagaggct cactacagaa atatgtaatc     5520

agtgctgtgc atctgtctgc agctaatgta cctcctggac accaggaggg gaaaaagcac     5580

tttttcaatt gtgctgagtt agacatctgt gagttagact atggtgtcag tgatttttgc     5640

agaacacgtg cacaaccctg aggtatgttt aatctaggca ggtacgttta aggatatttt     5700

gatctattta taatgaattc acaatttatg cctataaatt tcagatgatt taaaatttta     5760

aacctgttac attgaaaaac attgaagttc gtcttgaaga aagcattaag gtatgcatgg     5820

aggtgattta tttttaaaca taacacctaa cctaacatgg gtaagagagt atggaactag     5880

atatgagctg tataagaagc ataattgtga acaagtagat tgattgcctt catatacaag     5940

tatgttttag tattccttat ttccttatta tcagatgtat tttttctttt aagtttcaat     6000

gttgttataa ttctcaacca gaaatttaat actttctaaa atatttttta aatttagctt     6060

gtgcttttga attacaggag aagggaatca taatttaata aaacgcttac tagaaagacc     6120

attacagatc ccaaacactt gggtttggtg accctgtctt tcttatatga ccctacaata     6180

aacatttgaa ggcagcatag gatggcagac agtaggaaca ttgtttcact tggcggcatg     6240

tttttgaaac ctgctttata gtaactgggt gattgccatt gtggtagagc ttccactgct     6300

gtttataatc tgagagagtt aatctcagag gatgcttttt tccttttaat ctgctatgaa     6360

tcagtaccca gatgtttaat tactgtactt attaaatcat gagggcaaaa gagtgtagaa     6420

tggaaaaaag tctcttgtat ctagatactt taaatatggg aggcccttta acttaattgc     6480

ctttagtcaa ccactggatt tgaatttgca tcaagtattt taaataatat tgaatttaaa     6540

aaaatgtatt gcagtagtgt gtcagtacct tattgttaaa gtgagtcaga taaatcttca     6600

attcctggct atttgggcaa ttgaatcatc atggactgta taatgcaatc agattatttt     6660

gtttctagac atccttgaat tacaccaaag aacatgaaat ttagttgtgg ttaaattatt     6720

tatttatttc atgcattcat tttatttccc ttaaggtctg gatgagactt ctttggggag     6780

cctctaaaaa aatttttcac tgggggccac gtgggtcatt agaagccaga gctctcctcc     6840

aggctccttc ccagtgccta gaggtgctat aggaaacata gatccagcca ggggcttccc     6900

taaagcagtg cagcaccggc ccagggcatc actagacagg ccctaattaa gtttttttta     6960

aaaagcctgt gtatttattt tagaatcatg tttttctgta tattaacttg ggggatatcg     7020

ttaatattta ggatataaga tttgaggtca gccatcttca aaaaagaaaa aaaaattgac     7080

tcaagaaagt acaagtaaac tatacacctt tttttcataa gttttaggaa ctgtagtaat     7140

gtggcttaga aagtataatg gcctaaatgt tttcaaaatg taagttcctg tggagaagaa     7200

ttgtttatat tgcaaacggg gggactgagg ggaacctgta ggtttaaaac agtatgtttg     7260

tcagccaact gatttaaaag gcctttaact gttttggttg ttgttttttt tttaagccac     7320

tctccccttc ctatgaggaa gaattgagag gggcacctat ttctgtaaaa tccccaaatt     7380

ggtgttgatg attttgagct tgaatgtttt catacctgat taaaacttgg tttattctaa     7440

tttctgtatc atatcatctg aggtttacgt ggtaactagt cttataacat gtatgtatct     7500

tttttttgtt gttcatctaa agctttttaa tccaaataaa tacagagttt gcaaagtgat     7560

ttggattaac caggaaaaaa aaaaaaaaaa aa                                   7592


<210>  2
<211>  1582
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ser Lys Arg Arg Arg Ala Thr Ser Pro Ser Ser Ser Val Ser 
1               5                   10                  15      


Gly Asp Phe Asp Asp Gly His His Ser Val Ser Thr Pro Gly Pro Ser 
            20                  25                  30          


Arg Lys Arg Arg Arg Leu Ser Asn Leu Pro Thr Val Asp Pro Ile Ala 
        35                  40                  45              


Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr Lys Asp Glu Gln 
    50                  55                  60                  


Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro Lys Arg Arg Asn 
65                  70                  75                  80  


Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile Asp Leu Met Lys 
                85                  90                  95      


Ile Gln Gln Lys Leu Lys Met Glu Glu Tyr Asp Asp Val Asn Leu Leu 
            100                 105                 110         


Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys Ser Tyr Tyr Lys 
        115                 120                 125             


Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu Trp Asp Leu Tyr 
    130                 135                 140                 


Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu Ala Asp Asp Glu 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Gly Gln Asp Asn Gln Gly Thr Val Thr Glu Gly 
                165                 170                 175     


Ser Ser Pro Ala Tyr Leu Lys Glu Ile Leu Glu Gln Leu Leu Glu Ala 
            180                 185                 190         


Ile Val Val Ala Thr Asn Pro Ser Gly Arg Leu Ile Ser Glu Leu Phe 
        195                 200                 205             


Gln Lys Leu Pro Ser Lys Val Gln Tyr Pro Asp Tyr Tyr Ala Ile Ile 
    210                 215                 220                 


Lys Glu Pro Ile Asp Leu Lys Thr Ile Ala Gln Arg Ile Gln Asn Gly 
225                 230                 235                 240 


Ser Tyr Lys Ser Ile His Ala Met Ala Lys Asp Ile Asp Leu Leu Ala 
                245                 250                 255     


Lys Asn Ala Lys Thr Tyr Asn Glu Pro Gly Ser Gln Val Phe Lys Asp 
            260                 265                 270         


Ala Asn Ser Ile Lys Lys Ile Phe Tyr Met Lys Lys Ala Glu Ile Glu 
        275                 280                 285             


His His Glu Met Ala Lys Ser Ser Leu Arg Met Arg Thr Pro Ser Asn 
    290                 295                 300                 


Leu Ala Ala Ala Arg Leu Thr Gly Pro Ser His Ser Lys Gly Ser Leu 
305                 310                 315                 320 


Gly Glu Glu Arg Asn Pro Thr Ser Lys Tyr Tyr Arg Asn Lys Arg Ala 
                325                 330                 335     


Val Gln Gly Gly Arg Leu Ser Ala Ile Thr Met Ala Leu Gln Tyr Gly 
            340                 345                 350         


Ser Glu Ser Glu Glu Asp Ala Ala Leu Ala Ala Ala Arg Tyr Glu Glu 
        355                 360                 365             


Gly Glu Ser Glu Ala Glu Ser Ile Thr Ser Phe Met Asp Val Ser Asn 
    370                 375                 380                 


Pro Phe Tyr Gln Leu Tyr Asp Thr Val Arg Ser Cys Arg Asn Asn Gln 
385                 390                 395                 400 


Gly Gln Leu Ile Ala Glu Pro Phe Tyr His Leu Pro Ser Lys Lys Lys 
                405                 410                 415     


Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile Ser Leu Gln Gln 
            420                 425                 430         


Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr Leu Asp His Leu 
        435                 440                 445             


Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys Arg Tyr Asn Val 
    450                 455                 460                 


Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu Gln Gln Val Met 
465                 470                 475                 480 


Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp Ile Glu Asp Gly 
                485                 490                 495     


Asp Ser Met Ile Ser Ser Ala Thr Ser Asp Thr Gly Ser Ala Lys Arg 
            500                 505                 510         


Lys Ser Lys Lys Asn Ile Arg Lys Gln Arg Met Lys Ile Leu Phe Asn 
        515                 520                 525             


Val Val Leu Glu Ala Arg Glu Pro Gly Ser Gly Arg Arg Leu Cys Asp 
    530                 535                 540                 


Leu Phe Met Val Lys Pro Ser Lys Lys Asp Tyr Pro Asp Tyr Tyr Lys 
545                 550                 555                 560 


Ile Ile Leu Glu Pro Met Asp Leu Lys Ile Ile Glu His Asn Ile Arg 
                565                 570                 575     


Asn Asp Lys Tyr Ala Gly Glu Glu Gly Met Ile Glu Asp Met Lys Leu 
            580                 585                 590         


Met Phe Arg Asn Ala Arg His Tyr Asn Glu Glu Gly Ser Gln Val Tyr 
        595                 600                 605             


Asn Asp Ala His Ile Leu Glu Lys Leu Leu Lys Glu Lys Arg Lys Glu 
    610                 615                 620                 


Leu Gly Pro Leu Pro Asp Asp Asp Asp Met Ala Ser Pro Lys Leu Lys 
625                 630                 635                 640 


Leu Ser Arg Lys Ser Gly Ile Ser Pro Lys Lys Ser Lys Tyr Met Thr 
                645                 650                 655     


Pro Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val Lys Asn Tyr 
            660                 665                 670         


Thr Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu Arg Leu Pro 
        675                 680                 685             


Ser Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys Lys Pro Met 
    690                 695                 700                 


Asp Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys Tyr Gln Asp 
705                 710                 715                 720 


Ile Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn Asn Ala Cys 
                725                 730                 735     


Thr Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala Leu Val Leu 
            740                 745                 750         


His Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly Asp Glu Asp 
        755                 760                 765             


Ser His Val Pro Asn Val Thr Leu Leu Ile Gln Glu Leu Ile His Asn 
    770                 775                 780                 


Leu Phe Val Ser Val Met Ser His Gln Asp Asp Glu Gly Arg Cys Tyr 
785                 790                 795                 800 


Ser Asp Ser Leu Ala Glu Ile Pro Ala Val Asp Pro Asn Phe Pro Asn 
                805                 810                 815     


Lys Pro Pro Leu Thr Phe Asp Ile Ile Arg Lys Asn Val Glu Asn Asn 
            820                 825                 830         


Arg Tyr Arg Arg Leu Asp Leu Phe Gln Glu His Met Phe Glu Val Leu 
        835                 840                 845             


Glu Arg Ala Arg Arg Met Asn Arg Thr Asp Ser Glu Ile Tyr Glu Asp 
    850                 855                 860                 


Ala Val Glu Leu Gln Gln Phe Phe Ile Lys Ile Arg Asp Glu Leu Cys 
865                 870                 875                 880 


Lys Asn Gly Glu Ile Leu Leu Ser Pro Ala Leu Ser Tyr Thr Thr Lys 
                885                 890                 895     


His Leu His Asn Asp Val Glu Lys Glu Arg Lys Glu Lys Leu Pro Lys 
            900                 905                 910         


Glu Ile Glu Glu Asp Lys Leu Lys Arg Glu Glu Glu Lys Arg Glu Ala 
        915                 920                 925             


Glu Lys Ser Glu Asp Ser Ser Gly Ala Ala Gly Leu Ser Gly Leu His 
    930                 935                 940                 


Arg Thr Tyr Ser Gln Asp Cys Ser Phe Lys Asn Ser Met Tyr His Val 
945                 950                 955                 960 


Gly Asp Tyr Val Tyr Val Glu Pro Ala Glu Ala Asn Leu Gln Pro His 
                965                 970                 975     


Ile Val Cys Ile Glu Arg Leu Trp Glu Asp Ser Ala Glu Lys Glu Val 
            980                 985                 990         


Phe Lys Ser Asp Tyr Tyr Asn Lys  Val Pro Val Ser Lys  Ile Leu Gly 
        995                 1000                 1005             


Lys Cys  Val Val Met Phe Val  Lys Glu Tyr Phe Lys  Leu Cys Pro 
    1010                 1015                 1020             


Glu Asn  Phe Arg Asp Glu Asp  Val Phe Val Cys Glu  Ser Arg Tyr 
    1025                 1030                 1035             


Ser Ala  Lys Thr Lys Ser Phe  Lys Lys Ile Lys Leu  Trp Thr Met 
    1040                 1045                 1050             


Pro Ile  Ser Ser Val Arg Phe  Val Pro Arg Asp Val  Pro Leu Pro 
    1055                 1060                 1065             


Val Val  Arg Val Ala Ser Val  Phe Ala Asn Ala Asp  Lys Gly Asp 
    1070                 1075                 1080             


Asp Glu  Lys Asn Thr Asp Asn  Ser Glu Asp Ser Arg  Ala Glu Asp 
    1085                 1090                 1095             


Asn Phe  Asn Leu Glu Lys Glu  Lys Glu Asp Val Pro  Val Glu Met 
    1100                 1105                 1110             


Ser Asn  Gly Glu Pro Gly Cys  His Tyr Phe Glu Gln  Leu His Tyr 
    1115                 1120                 1125             


Asn Asp  Met Trp Leu Lys Val  Gly Asp Cys Val Phe  Ile Lys Ser 
    1130                 1135                 1140             


His Gly  Leu Val Arg Pro Arg  Val Gly Arg Ile Glu  Lys Val Trp 
    1145                 1150                 1155             


Val Arg  Asp Gly Ala Ala Tyr  Phe Tyr Gly Pro Ile  Phe Ile His 
    1160                 1165                 1170             


Pro Glu  Glu Thr Glu His Glu  Pro Thr Lys Met Phe  Tyr Lys Lys 
    1175                 1180                 1185             


Glu Val  Phe Leu Ser Asn Leu  Glu Glu Thr Cys Pro  Met Thr Cys 
    1190                 1195                 1200             


Ile Leu  Gly Lys Cys Ala Val  Leu Ser Phe Lys Asp  Phe Leu Ser 
    1205                 1210                 1215             


Cys Arg  Pro Thr Glu Ile Pro  Glu Asn Asp Ile Leu  Leu Cys Glu 
    1220                 1225                 1230             


Ser Arg  Tyr Asn Glu Ser Asp  Lys Gln Met Lys Lys  Phe Lys Gly 
    1235                 1240                 1245             


Leu Lys  Arg Phe Ser Leu Ser  Ala Lys Val Val Asp  Asp Glu Ile 
    1250                 1255                 1260             


Tyr Tyr  Phe Arg Lys Pro Ile  Val Pro Gln Lys Glu  Pro Ser Pro 
    1265                 1270                 1275             


Leu Leu  Glu Lys Lys Ile Gln  Leu Leu Glu Ala Lys  Phe Ala Glu 
    1280                 1285                 1290             


Leu Glu  Gly Gly Asp Asp Asp  Ile Glu Glu Met Gly  Glu Glu Asp 
    1295                 1300                 1305             


Ser Glu  Ser Thr Pro Lys Ser  Ala Lys Gly Ser Ala  Lys Lys Glu 
    1310                 1315                 1320             


Gly Ser  Lys Arg Lys Ile Asn  Met Ser Gly Tyr Ile  Leu Phe Ser 
    1325                 1330                 1335             


Ser Glu  Met Arg Ala Val Ile  Lys Ala Gln His Pro  Asp Tyr Ser 
    1340                 1345                 1350             


Phe Gly  Glu Leu Ser Arg Leu  Val Gly Thr Glu Trp  Arg Asn Leu 
    1355                 1360                 1365             


Glu Thr  Ala Lys Lys Ala Glu  Tyr Glu Gly Met Met  Gly Gly Tyr 
    1370                 1375                 1380             


Pro Pro  Gly Leu Pro Pro Leu  Gln Gly Pro Val Asp  Gly Leu Val 
    1385                 1390                 1395             


Ser Met  Gly Ser Met Gln Pro  Leu His Pro Gly Gly  Pro Pro Pro 
    1400                 1405                 1410             


His His  Leu Pro Pro Gly Val  Pro Gly Leu Pro Gly  Ile Pro Pro 
    1415                 1420                 1425             


Pro Gly  Val Met Asn Gln Gly  Val Ala Pro Met Val  Gly Thr Pro 
    1430                 1435                 1440             


Ala Pro  Gly Gly Ser Pro Tyr  Gly Gln Gln Val Gly  Val Leu Gly 
    1445                 1450                 1455             


Pro Pro  Gly Gln Gln Ala Pro  Pro Pro Tyr Pro Gly  Pro His Pro 
    1460                 1465                 1470             


Ala Gly  Pro Pro Val Ile Gln  Gln Pro Thr Thr Pro  Met Phe Val 
    1475                 1480                 1485             


Ala Pro  Pro Pro Lys Thr Gln  Arg Leu Leu His Ser  Glu Ala Tyr 
    1490                 1495                 1500             


Leu Lys  Tyr Ile Glu Gly Leu  Ser Ala Glu Ser Asn  Ser Ile Ser 
    1505                 1510                 1515             


Lys Trp  Asp Gln Thr Leu Ala  Ala Arg Arg Arg Asp  Val His Leu 
    1520                 1525                 1530             


Ser Lys  Glu Gln Glu Ser Arg  Leu Pro Ser His Trp  Leu Lys Ser 
    1535                 1540                 1545             


Lys Gly  Ala His Thr Thr Met  Ala Asp Ala Leu Trp  Arg Leu Arg 
    1550                 1555                 1560             


Asp Leu  Met Leu Arg Asp Thr  Leu Asn Ile Arg Gln  Ala Tyr Asn 
    1565                 1570                 1575             


Leu Glu  Asn Val 
    1580         


<210>  3
<211>  7609
<212>  DNA
<213>  Homo sapiens

<400>  3
gcggccgggg ctgcaggcgg cggagcggct ggcttgccaa cacttggtgt cacatgtgag       60

cctcccacat gtattcactc tccattccag ctctgtgatt gaactctgct cttattgact      120

agggggcagt tgggcaggca tgcctcattc ctggaattga cagtcattcc taataagttg      180

gattccatgg gttccaagag aagaagagct acctcccctt ccagcagtgt cagcggggac      240

tttgatgatg ggcaccattc tgtgtcaaca ccaggcccaa gcaggaaaag gaggagactt      300

tccaatcttc caactgtaga tcctattgcc gtgtgccatg aactctataa taccatccga      360

gactataagg atgaacaggg cagacttctc tgtgagctct tcattagggc accaaagcga      420

agaaatcaac cagactatta tgaagtggtt tctcagccca ttgacttgat gaaaatccaa      480

cagaaactaa aaatggaaga gtatgatgat gttaatttgc tgactgctga cttccagctt      540

ctttttaaca atgcaaagtc ctattataag ccagattctc ctgaatataa agccgcttgc      600

aaactctggg atttgtacct tcgaacaaga aatgagtttg ttcagaaagg agaagcagat      660

gacgaagatg atgatgaaga tgggcaagac aatcagggca cagtgactga aggatcttct      720

ccagcttact tgaaggagat cctggagcag cttcttgaag ccatagttgt agctacaaat      780

ccatcaggac gtctcattag cgaacttttt cagaaactgc cttctaaagt gcaatatcca      840

gattattatg caataattaa ggagcctata gatctcaaga ccattgccca gaggatacag      900

aatggaagct acaaaagtat tcatgcaatg gccaaagata tagatctcct cgcaaaaaat      960

gccaaaactt ataatgagcc tggctctcaa gtattcaagg atgcaaattc aattaaaaaa     1020

atattttata tgaaaaaggc tgaaattgaa catcatgaaa tggctaagtc aagtcttcga     1080

atgaggactc catccaactt ggctgcagcc agactgacag gtccttcaca cagtaaaggc     1140

agccttggtg aagagagaaa tcccactagc aagtattacc gtaataaaag agcagtacaa     1200

ggaggtcgtt tatcagcaat tacaatggca cttcaatatg gctcagaaag tgaagaagat     1260

gctgctttag ctgctgcacg ctatgaagag ggagagtcag aagcagaaag catcacttcc     1320

tttatggatg tttcaaatcc tttttatcag ctttatgaca cagttaggag ttgtcggaat     1380

aaccaagggc agctaatagc tgaacctttt taccatttgc cttcaaagaa aaaataccct     1440

gattattacc agcaaattaa aatgcccata tcactacaac agatccgaac aaaactgaag     1500

aatcaagaat atgaaacttt agatcatttg gagtgtgatc tgaatttaat gtttgaaaat     1560

gccaaacgct ataatgtgcc caattcagcc atctacaagc gagttctaaa attgcagcaa     1620

gttatgcagg caaagaagaa agagcttgcc aggagagacg atatcgagga cggagacagc     1680

atgatctctt cagccacctc tgatactggt agtgccaaaa gaaaaagtaa aaagaacata     1740

agaaagcagc gaatgaaaat cttattcaat gttgttcttg aagctcgaga gccaggttca     1800

ggcagaagac tttgtgacct atttatggtt aaaccatcca aaaaggacta tcctgattat     1860

tataaaatca tcttggagcc aatggacttg aaaataattg agcataacat ccgcaatgac     1920

aaatatgctg gtgaagaggg aatgatagaa gacatgaagc tgatgttccg gaatgccagg     1980

cactataatg aggagggctc ccaggtttat aatgatgcac atatcctgga gaagttactc     2040

aaggagaaaa ggaaagagct gggcccactg cctgatgatg atgacatggc ttctcccaaa     2100

ctcaagctga gtaggaagag tggcatttct cctaaaaaat caaaatacat gactccaatg     2160

cagcagaaac taaatgaggt ctatgaagct gtaaagaact atactgataa gaggggtcgc     2220

cgcctcagtg ccatatttct gaggcttccc tctagatctg agttgcctga ctactatctg     2280

actattaaaa agcccatgga catggaaaaa attcgaagtc acatgatggc caacaagtac     2340

caagatattg actctatggt tgaggacttt gtcatgatgt ttaataatgc ctgtacatac     2400

aatgagccgg agtctttgat ctacaaagat gctcttgttc tacacaaagt cctgcttgaa     2460

acacgcagag acctggaggg agatgaggac tctcatgtcc caaatgtgac tttgctgatt     2520

caagagctta tccacaatct ttttgtgtca gtcatgagtc atcaggatga tgagggaaga     2580

tgctacagcg attctttagc agaaattcct gctgtggatc ccaactttcc taacaaacca     2640

ccccttacat ttgacataat taggaagaat gttgaaaata atcgctaccg tcggcttgat     2700

ttatttcaag agcatatgtt tgaagtattg gaacgagcaa gaaggatgaa tcggacagat     2760

tcagaaatat atgaagatgc agtagaactt cagcagtttt ttattaaaat tcgtgatgaa     2820

ctctgcaaaa atggagagat tcttctttca ccggcactca gctataccac aaaacatttg     2880

cataatgatg tggagaaaga gagaaaggaa aaattgccaa aagaaataga ggaagataaa     2940

ctaaaacgag aagaagaaaa aagagaagct gaaaagagtg aagattcctc tggtgctgca     3000

ggcctctcag gcttacatcg cacatacagc caggactgta gctttaaaaa cagcatgtac     3060

catgttggag attacgtcta tgtggaacct gcagaggcca acctacaacc acatatcgtc     3120

tgtattgaaa gactgtggga ggattcagct ggtgaaaaat ggttgtatgg ctgttggttt     3180

taccgaccaa atgaaacatt ccacctggct acacgaaaat ttctagaaaa agaagttttt     3240

aagagtgact attacaacaa agttccagtt agtaaaattc taggcaagtg tgtggtcatg     3300

tttgtcaagg aatactttaa gttatgccca gaaaacttcc gagatgagga tgtttttgtc     3360

tgtgaatcac ggtattctgc caaaaccaaa tcttttaaga aaattaaact gtggaccatg     3420

cccatcagct cagtcaggtt tgtccctcgg gatgtgcctc tgcctgtggt tcgcgtggcc     3480

tctgtatttg caaatgcaga taaaggtgat gatgagaaga atacagacaa ctcagaggac     3540

agtcgagctg aagacaattt taacttggaa aaggaaaaag aagatgtccc tgtggaaatg     3600

tccaatggtg aaccaggttg ccactacttt gagcagctcc attacaatga catgtggctg     3660

aaggttggcg actgtgtctt catcaagtcc catggcctgg tgcgtcctcg tgtgggcaga     3720

attgaaaaag tatgggttcg agatggagct gcatattttt atggccccat cttcattcac     3780

ccagaagaaa cagagcatga gcccacaaaa atgttctaca aaaaagaagt atttctgagt     3840

aatctggaag aaacctgccc catgacatgt attctcggaa agtgtgctgt gttgtcattc     3900

aaggacttcc tctcctgcag gccaactgaa ataccagaaa atgacattct gctttgtgag     3960

agccgctaca atgagagcga caagcagatg aagaaattca aaggattgaa gaggttttca     4020

ctctctgcta aagtggtaga tgatgaaatt tactacttca gaaaaccaat tgttcctcag     4080

aaggagccat cacctttgct ggaaaagaag atccagttgc tagaagctaa atttgccgag     4140

ttagaaggtg gagatgatga tattgaagag atgggagaag aagatagtga ggtcattgaa     4200

cctccttctc tacctcagct tcagaccccc ctggccagtg agctggacct catgccctac     4260

acacccccac agtctacccc aaagtctgcc aaaggcagtg caaagaagga aggctccaaa     4320

cggaaaatca acatgagtgg ctacatcctg ttcagcagtg agatgagggc tgtgattaag     4380

gcccaacacc cagactactc tttcggggag ctcagccgcc tggtggggac agaatggaga     4440

aatcttgaga cagccaagaa agcagaatat gaaggtgtga tgaaccaagg agtggcccct     4500

atggtaggga ctccagcacc aggtggaagt ccatatggac aacaggtggg agttttgggg     4560

cctccagggc agcaggcacc acctccatat cccggcccac atccagctgg accccctgtc     4620

atacagcagc caacaacacc catgtttgta gctcccccac caaagaccca gcggcttctt     4680

cactcagagg cctacctgaa atacattgaa ggactcagtg cggagtccaa cagcattagc     4740

aagtgggatc agacactggc agctcgaaga cgcgacgtcc atttgtcgaa agaacaggag     4800

agccgcctac cctctcactg gctgaaaagc aaaggggccc acaccaccat ggcagatgcc     4860

ctctggcgcc ttcgagattt gatgctccgg gacaccctca acattcgcca agcatacaac     4920

ctagaaaatg tttaatcaca tcattacgtt tcttttatat agaagcataa agagttgtgg     4980

atcagtagcc attttagtta ctgggggtgg ggggaaggaa caaaggagga taatttttat     5040

tgcattttac tgtacatcac aaggccattt ttatatacgg acacttttaa taagctattt     5100

caatttgttt gttatattaa gttgacttta tcaaatacac aaagattttt ttgcatatgt     5160

ttccttcgtt taaaaccagt ttcataattg gttgtatatg tagacttgga gttttatctt     5220

tttacttgtt gccatggaac tgaaaccatt agaggttttt gtcttggctt ggggtttttg     5280

ttttcttggt tttgggtttt tttatatata tatataaaag aacaaaatga aaaaaaacac     5340

acacacacaa gagtttacag attagtttaa attgataatg aaatgtgaag tttgtcctag     5400

tttacatctt agagagggga gtatacttgt gtttgtttca tgtgcctgaa tatcttaagc     5460

cactttctgc aaaagctgtt tcttacagat gaagtgcttt ctttgaaagg tggttattta     5520

ggttttagat gtttaataga cacagcacat ttgctctatt aactcagagg ctcactacag     5580

aaatatgtaa tcagtgctgt gcatctgtct gcagctaatg tacctcctgg acaccaggag     5640

gggaaaaagc actttttcaa ttgtgctgag ttagacatct gtgagttaga ctatggtgtc     5700

agtgattttt gcagaacacg tgcacaaccc tgaggtatgt ttaatctagg caggtacgtt     5760

taaggatatt ttgatctatt tataatgaat tcacaattta tgcctataaa tttcagatga     5820

tttaaaattt taaacctgtt acattgaaaa acattgaagt tcgtcttgaa gaaagcatta     5880

aggtatgcat ggaggtgatt tatttttaaa cataacacct aacctaacat gggtaagaga     5940

gtatggaact agatatgagc tgtataagaa gcataattgt gaacaagtag attgattgcc     6000

ttcatataca agtatgtttt agtattcctt atttccttat tatcagatgt attttttctt     6060

ttaagtttca atgttgttat aattctcaac cagaaattta atactttcta aaatattttt     6120

taaatttagc ttgtgctttt gaattacagg agaagggaat cataatttaa taaaacgctt     6180

actagaaaga ccattacaga tcccaaacac ttgggtttgg tgaccctgtc tttcttatat     6240

gaccctacaa taaacatttg aaggcagcat aggatggcag acagtaggaa cattgtttca     6300

cttggcggca tgtttttgaa acctgcttta tagtaactgg gtgattgcca ttgtggtaga     6360

gcttccactg ctgtttataa tctgagagag ttaatctcag aggatgcttt tttcctttta     6420

atctgctatg aatcagtacc cagatgttta attactgtac ttattaaatc atgagggcaa     6480

aagagtgtag aatggaaaaa agtctcttgt atctagatac tttaaatatg ggaggccctt     6540

taacttaatt gcctttagtc aaccactgga tttgaatttg catcaagtat tttaaataat     6600

attgaattta aaaaaatgta ttgcagtagt gtgtcagtac cttattgtta aagtgagtca     6660

gataaatctt caattcctgg ctatttgggc aattgaatca tcatggactg tataatgcaa     6720

tcagattatt ttgtttctag acatccttga attacaccaa agaacatgaa atttagttgt     6780

ggttaaatta tttatttatt tcatgcattc attttatttc ccttaaggtc tggatgagac     6840

ttctttgggg agcctctaaa aaaatttttc actgggggcc acgtgggtca ttagaagcca     6900

gagctctcct ccaggctcct tcccagtgcc tagaggtgct ataggaaaca tagatccagc     6960

caggggcttc cctaaagcag tgcagcaccg gcccagggca tcactagaca ggccctaatt     7020

aagttttttt taaaaagcct gtgtatttat tttagaatca tgtttttctg tatattaact     7080

tgggggatat cgttaatatt taggatataa gatttgaggt cagccatctt caaaaaagaa     7140

aaaaaaattg actcaagaaa gtacaagtaa actatacacc tttttttcat aagttttagg     7200

aactgtagta atgtggctta gaaagtataa tggcctaaat gttttcaaaa tgtaagttcc     7260

tgtggagaag aattgtttat attgcaaacg gggggactga ggggaacctg taggtttaaa     7320

acagtatgtt tgtcagccaa ctgatttaaa aggcctttaa ctgttttggt tgttgttttt     7380

tttttaagcc actctcccct tcctatgagg aagaattgag aggggcacct atttctgtaa     7440

aatccccaaa ttggtgttga tgattttgag cttgaatgtt ttcatacctg attaaaactt     7500

ggtttattct aatttctgta tcatatcatc tgaggtttac gtggtaacta gtcttataac     7560

atgtatgtat cttttttttg ttgttcatct aaagcttttt aatccaaat                 7609


<210>  4
<211>  1582
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ser Lys Arg Arg Arg Ala Thr Ser Pro Ser Ser Ser Val Ser 
1               5                   10                  15      


Gly Asp Phe Asp Asp Gly His His Ser Val Ser Thr Pro Gly Pro Ser 
            20                  25                  30          


Arg Lys Arg Arg Arg Leu Ser Asn Leu Pro Thr Val Asp Pro Ile Ala 
        35                  40                  45              


Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr Lys Asp Glu Gln 
    50                  55                  60                  


Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro Lys Arg Arg Asn 
65                  70                  75                  80  


Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile Asp Leu Met Lys 
                85                  90                  95      


Ile Gln Gln Lys Leu Lys Met Glu Glu Tyr Asp Asp Val Asn Leu Leu 
            100                 105                 110         


Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys Ser Tyr Tyr Lys 
        115                 120                 125             


Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu Trp Asp Leu Tyr 
    130                 135                 140                 


Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu Ala Asp Asp Glu 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Gly Gln Asp Asn Gln Gly Thr Val Thr Glu Gly 
                165                 170                 175     


Ser Ser Pro Ala Tyr Leu Lys Glu Ile Leu Glu Gln Leu Leu Glu Ala 
            180                 185                 190         


Ile Val Val Ala Thr Asn Pro Ser Gly Arg Leu Ile Ser Glu Leu Phe 
        195                 200                 205             


Gln Lys Leu Pro Ser Lys Val Gln Tyr Pro Asp Tyr Tyr Ala Ile Ile 
    210                 215                 220                 


Lys Glu Pro Ile Asp Leu Lys Thr Ile Ala Gln Arg Ile Gln Asn Gly 
225                 230                 235                 240 


Ser Tyr Lys Ser Ile His Ala Met Ala Lys Asp Ile Asp Leu Leu Ala 
                245                 250                 255     


Lys Asn Ala Lys Thr Tyr Asn Glu Pro Gly Ser Gln Val Phe Lys Asp 
            260                 265                 270         


Ala Asn Ser Ile Lys Lys Ile Phe Tyr Met Lys Lys Ala Glu Ile Glu 
        275                 280                 285             


His His Glu Met Ala Lys Ser Ser Leu Arg Met Arg Thr Pro Ser Asn 
    290                 295                 300                 


Leu Ala Ala Ala Arg Leu Thr Gly Pro Ser His Ser Lys Gly Ser Leu 
305                 310                 315                 320 


Gly Glu Glu Arg Asn Pro Thr Ser Lys Tyr Tyr Arg Asn Lys Arg Ala 
                325                 330                 335     


Val Gln Gly Gly Arg Leu Ser Ala Ile Thr Met Ala Leu Gln Tyr Gly 
            340                 345                 350         


Ser Glu Ser Glu Glu Asp Ala Ala Leu Ala Ala Ala Arg Tyr Glu Glu 
        355                 360                 365             


Gly Glu Ser Glu Ala Glu Ser Ile Thr Ser Phe Met Asp Val Ser Asn 
    370                 375                 380                 


Pro Phe Tyr Gln Leu Tyr Asp Thr Val Arg Ser Cys Arg Asn Asn Gln 
385                 390                 395                 400 


Gly Gln Leu Ile Ala Glu Pro Phe Tyr His Leu Pro Ser Lys Lys Lys 
                405                 410                 415     


Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile Ser Leu Gln Gln 
            420                 425                 430         


Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr Leu Asp His Leu 
        435                 440                 445             


Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys Arg Tyr Asn Val 
    450                 455                 460                 


Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu Gln Gln Val Met 
465                 470                 475                 480 


Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp Ile Glu Asp Gly 
                485                 490                 495     


Asp Ser Met Ile Ser Ser Ala Thr Ser Asp Thr Gly Ser Ala Lys Arg 
            500                 505                 510         


Lys Ser Lys Lys Asn Ile Arg Lys Gln Arg Met Lys Ile Leu Phe Asn 
        515                 520                 525             


Val Val Leu Glu Ala Arg Glu Pro Gly Ser Gly Arg Arg Leu Cys Asp 
    530                 535                 540                 


Leu Phe Met Val Lys Pro Ser Lys Lys Asp Tyr Pro Asp Tyr Tyr Lys 
545                 550                 555                 560 


Ile Ile Leu Glu Pro Met Asp Leu Lys Ile Ile Glu His Asn Ile Arg 
                565                 570                 575     


Asn Asp Lys Tyr Ala Gly Glu Glu Gly Met Ile Glu Asp Met Lys Leu 
            580                 585                 590         


Met Phe Arg Asn Ala Arg His Tyr Asn Glu Glu Gly Ser Gln Val Tyr 
        595                 600                 605             


Asn Asp Ala His Ile Leu Glu Lys Leu Leu Lys Glu Lys Arg Lys Glu 
    610                 615                 620                 


Leu Gly Pro Leu Pro Asp Asp Asp Asp Met Ala Ser Pro Lys Leu Lys 
625                 630                 635                 640 


Leu Ser Arg Lys Ser Gly Ile Ser Pro Lys Lys Ser Lys Tyr Met Thr 
                645                 650                 655     


Pro Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val Lys Asn Tyr 
            660                 665                 670         


Thr Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu Arg Leu Pro 
        675                 680                 685             


Ser Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys Lys Pro Met 
    690                 695                 700                 


Asp Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys Tyr Gln Asp 
705                 710                 715                 720 


Ile Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn Asn Ala Cys 
                725                 730                 735     


Thr Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala Leu Val Leu 
            740                 745                 750         


His Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly Asp Glu Asp 
        755                 760                 765             


Ser His Val Pro Asn Val Thr Leu Leu Ile Gln Glu Leu Ile His Asn 
    770                 775                 780                 


Leu Phe Val Ser Val Met Ser His Gln Asp Asp Glu Gly Arg Cys Tyr 
785                 790                 795                 800 


Ser Asp Ser Leu Ala Glu Ile Pro Ala Val Asp Pro Asn Phe Pro Asn 
                805                 810                 815     


Lys Pro Pro Leu Thr Phe Asp Ile Ile Arg Lys Asn Val Glu Asn Asn 
            820                 825                 830         


Arg Tyr Arg Arg Leu Asp Leu Phe Gln Glu His Met Phe Glu Val Leu 
        835                 840                 845             


Glu Arg Ala Arg Arg Met Asn Arg Thr Asp Ser Glu Ile Tyr Glu Asp 
    850                 855                 860                 


Ala Val Glu Leu Gln Gln Phe Phe Ile Lys Ile Arg Asp Glu Leu Cys 
865                 870                 875                 880 


Lys Asn Gly Glu Ile Leu Leu Ser Pro Ala Leu Ser Tyr Thr Thr Lys 
                885                 890                 895     


His Leu His Asn Asp Val Glu Lys Glu Arg Lys Glu Lys Leu Pro Lys 
            900                 905                 910         


Glu Ile Glu Glu Asp Lys Leu Lys Arg Glu Glu Glu Lys Arg Glu Ala 
        915                 920                 925             


Glu Lys Ser Glu Asp Ser Ser Gly Ala Ala Gly Leu Ser Gly Leu His 
    930                 935                 940                 


Arg Thr Tyr Ser Gln Asp Cys Ser Phe Lys Asn Ser Met Tyr His Val 
945                 950                 955                 960 


Gly Asp Tyr Val Tyr Val Glu Pro Ala Glu Ala Asn Leu Gln Pro His 
                965                 970                 975     


Ile Val Cys Ile Glu Arg Leu Trp Glu Asp Ser Ala Gly Glu Lys Trp 
            980                 985                 990         


Leu Tyr Gly Cys Trp Phe Tyr Arg  Pro Asn Glu Thr Phe  His Leu Ala 
        995                 1000                 1005             


Thr Arg  Lys Phe Leu Glu Lys  Glu Val Phe Lys Ser  Asp Tyr Tyr 
    1010                 1015                 1020             


Asn Lys  Val Pro Val Ser Lys  Ile Leu Gly Lys Cys  Val Val Met 
    1025                 1030                 1035             


Phe Val  Lys Glu Tyr Phe Lys  Leu Cys Pro Glu Asn  Phe Arg Asp 
    1040                 1045                 1050             


Glu Asp  Val Phe Val Cys Glu  Ser Arg Tyr Ser Ala  Lys Thr Lys 
    1055                 1060                 1065             


Ser Phe  Lys Lys Ile Lys Leu  Trp Thr Met Pro Ile  Ser Ser Val 
    1070                 1075                 1080             


Arg Phe  Val Pro Arg Asp Val  Pro Leu Pro Val Val  Arg Val Ala 
    1085                 1090                 1095             


Ser Val  Phe Ala Asn Ala Asp  Lys Gly Asp Asp Glu  Lys Asn Thr 
    1100                 1105                 1110             


Asp Asn  Ser Glu Asp Ser Arg  Ala Glu Asp Asn Phe  Asn Leu Glu 
    1115                 1120                 1125             


Lys Glu  Lys Glu Asp Val Pro  Val Glu Met Ser Asn  Gly Glu Pro 
    1130                 1135                 1140             


Gly Cys  His Tyr Phe Glu Gln  Leu His Tyr Asn Asp  Met Trp Leu 
    1145                 1150                 1155             


Lys Val  Gly Asp Cys Val Phe  Ile Lys Ser His Gly  Leu Val Arg 
    1160                 1165                 1170             


Pro Arg  Val Gly Arg Ile Glu  Lys Val Trp Val Arg  Asp Gly Ala 
    1175                 1180                 1185             


Ala Tyr  Phe Tyr Gly Pro Ile  Phe Ile His Pro Glu  Glu Thr Glu 
    1190                 1195                 1200             


His Glu  Pro Thr Lys Met Phe  Tyr Lys Lys Glu Val  Phe Leu Ser 
    1205                 1210                 1215             


Asn Leu  Glu Glu Thr Cys Pro  Met Thr Cys Ile Leu  Gly Lys Cys 
    1220                 1225                 1230             


Ala Val  Leu Ser Phe Lys Asp  Phe Leu Ser Cys Arg  Pro Thr Glu 
    1235                 1240                 1245             


Ile Pro  Glu Asn Asp Ile Leu  Leu Cys Glu Ser Arg  Tyr Asn Glu 
    1250                 1255                 1260             


Ser Asp  Lys Gln Met Lys Lys  Phe Lys Gly Leu Lys  Arg Phe Ser 
    1265                 1270                 1275             


Leu Ser  Ala Lys Val Val Asp  Asp Glu Ile Tyr Tyr  Phe Arg Lys 
    1280                 1285                 1290             


Pro Ile  Val Pro Gln Lys Glu  Pro Ser Pro Leu Leu  Glu Lys Lys 
    1295                 1300                 1305             


Ile Gln  Leu Leu Glu Ala Lys  Phe Ala Glu Leu Glu  Gly Gly Asp 
    1310                 1315                 1320             


Asp Asp  Ile Glu Glu Met Gly  Glu Glu Asp Ser Glu  Val Ile Glu 
    1325                 1330                 1335             


Pro Pro  Ser Leu Pro Gln Leu  Gln Thr Pro Leu Ala  Ser Glu Leu 
    1340                 1345                 1350             


Asp Leu  Met Pro Tyr Thr Pro  Pro Gln Ser Thr Pro  Lys Ser Ala 
    1355                 1360                 1365             


Lys Gly  Ser Ala Lys Lys Glu  Gly Ser Lys Arg Lys  Ile Asn Met 
    1370                 1375                 1380             


Ser Gly  Tyr Ile Leu Phe Ser  Ser Glu Met Arg Ala  Val Ile Lys 
    1385                 1390                 1395             


Ala Gln  His Pro Asp Tyr Ser  Phe Gly Glu Leu Ser  Arg Leu Val 
    1400                 1405                 1410             


Gly Thr  Glu Trp Arg Asn Leu  Glu Thr Ala Lys Lys  Ala Glu Tyr 
    1415                 1420                 1425             


Glu Gly  Val Met Asn Gln Gly  Val Ala Pro Met Val  Gly Thr Pro 
    1430                 1435                 1440             


Ala Pro  Gly Gly Ser Pro Tyr  Gly Gln Gln Val Gly  Val Leu Gly 
    1445                 1450                 1455             


Pro Pro  Gly Gln Gln Ala Pro  Pro Pro Tyr Pro Gly  Pro His Pro 
    1460                 1465                 1470             


Ala Gly  Pro Pro Val Ile Gln  Gln Pro Thr Thr Pro  Met Phe Val 
    1475                 1480                 1485             


Ala Pro  Pro Pro Lys Thr Gln  Arg Leu Leu His Ser  Glu Ala Tyr 
    1490                 1495                 1500             


Leu Lys  Tyr Ile Glu Gly Leu  Ser Ala Glu Ser Asn  Ser Ile Ser 
    1505                 1510                 1515             


Lys Trp  Asp Gln Thr Leu Ala  Ala Arg Arg Arg Asp  Val His Leu 
    1520                 1525                 1530             


Ser Lys  Glu Gln Glu Ser Arg  Leu Pro Ser His Trp  Leu Lys Ser 
    1535                 1540                 1545             


Lys Gly  Ala His Thr Thr Met  Ala Asp Ala Leu Trp  Arg Leu Arg 
    1550                 1555                 1560             


Asp Leu  Met Leu Arg Asp Thr  Leu Asn Ile Arg Gln  Ala Tyr Asn 
    1565                 1570                 1575             


Leu Glu  Asn Val 
    1580         


<210>  5
<211>  8117
<212>  DNA
<213>  Mus musculus

<400>  5
ggatttacgg cagcactggg aggggtgagg gcggtgaggg cggcgggtgc cggagagacg       60

gccgcggcca gaggagcgct agcagccgtg gcggccacgg ggcggggctc ggcggtcggg      120

gaccgcagcc ggggctgcag gcggcggagc ggcgggcttg ccaacacttg gtgtcacatg      180

tgagcctccc acatgtgtgc actctccatt ccagctctgt gattgaactc tgctcttatt      240

gactaggggg cacttgggca ggcatgcttc attcctggag ttgacagtca tttcataaga      300

agttggattc catgggttcc aagagaagaa gagccacctc tccttccagc agtgtcagtg      360

gagactttga tgacgggcac cattctgtgc ctacaccagg cccaagcagg aaaaggagaa      420

gactgtccaa tcttccaact gtagatccta ttgctgtgtg ccatgaactc tataacacca      480

tccgagacta taaggatgaa cagggcagac tcctctgtga gctgttcatt agggctccaa      540

agcggagaaa tcaaccagac tattatgaag tggtttctca gcccattgac ttgatgaaaa      600

tccaacagaa acttaaaatg gaagagtatg atgatgttaa tctactgact gctgacttcc      660

agctgctttt taacaatgca aaggcctact ataagccaga ttcccctgag tataaagctg      720

cttgtaaact ctgggatttg taccttcgaa caagaaatga gtttgttcag aaaggagaag      780

cagacgatga agatgatgac gaagatgggc aagacaatca aggcacactg gctgacggct      840

cttctccagg ttatctgaag gagatcctgg agcagcttct tgaagccata gttgtagcca      900

caaatccatc aggacggctc atcagtgaac tttttcagaa actgccttcc aaagtgcaat      960

atccagacta ttatgcaata attaaggaac ctatagatct caagaccatt gctcagagga     1020

tacagaatgg aagctacaaa agtatacacg caatggccaa agatatagat cttctagcaa     1080

aaaatgccaa aacatacaat gagcctgggt ctcaagtatt caaggatgcc aattcgatta     1140

aaaaaatatt ttatatgaaa aaggcagaaa ttgaacatca tgaaatgact aaatcaagtc     1200

ttcgaataag gactgcatca aatttggctg cagccaggct gacaggtcct tcgcacaata     1260

aaagcagcct tggtgaagaa agaaacccca ctagcaagta ttaccgtaat aaaagagcag     1320

tccaaggggg tcgcttgtca gcaattacca tggcacttca gtatggatca gagagtgaag     1380

aggacgctgc tttagctgct gcacgctatg aagaagggga atctgaagca gagagcatca     1440

cttccttcat ggacgtttcc aacccctttc atcagcttta cgacacagtt aggagctgta     1500

ggaatcacca agggcagctc atagctgaac ctttcttcca tttgccttca aagaaaaaat     1560

acccagatta ttatcagcaa attaaaatgc ccatatcact tcaacagatc agaacaaagc     1620

taaagaacca agaatatgaa actttagatc atttggagtg tgatctgaat ttaatgtttg     1680

aaaatgccaa acgttataac gttcccaatt cagccatcta taagcgagtt ctaaaactgc     1740

agcaagtcat gcaggcaaag aagaaggagc ttgcgaggag agatgacatt gaggacggag     1800

acagcatgat ctcctcagcc acttctgaca ctggtagtgc caaaaggaaa aggaatactc     1860

atgacagtga gatgttgggt ctcaggaggc tatccagtaa aaagaacata agaaaacagc     1920

gaatgaaaat tttattcaat gttgttcttg aagctcgaga gccaggttca ggcagaagac     1980

tttgcgatct atttatggtt aagccatcca agaaggacta tcctgattat tataaaatca     2040

tcttagagcc aatggacctg aaaataattg agcataacat ccgaaatgac aaatatgcag     2100

gtgaagaagg aatgatggaa gacatgaaac tcatgttccg caatgccagg cactacaatg     2160

aggagggctc ccaggtatac aatgatgccc atatcctgga gaagttactc aaagataaaa     2220

ggaaagagct gggccctctg cctgatgatg atgacatggc ttctcccaaa cttaaattga     2280

gtaggaagag tggtgtttct cctaagaaat caaagtacat gactccaatg cagcagaaac     2340

tgaatgaagt gtatgaagct gtaaagaact atactgataa gaggggtcgc cgccttagtg     2400

ctatatttct aagactcccc tctagatcag agctgcctga ctactacctg accattaaaa     2460

agcccatgga catggaaaaa attcgaagtc acatgatggc aaacaagtac caagacatag     2520

attctatggt agaggacttt gtcatgatgt ttaataatgc ctgtacctac aatgaaccag     2580

agtctttgat ctacaaagat gcccttgtac tgcataaagt cctccttgag actcggagag     2640

acctggaggg agatgaggat tctcatgtcc ctaatgtgac gttgctgatt caagagctca     2700

tccataacct ttttgtgtca gtcatgagtc atcaggatga cgaagggagg tgttacagcg     2760

actccttagc agaaattcct gctgtggatc ccaactctcc caataaacct ccccttacat     2820

ttgacattat caggaaaaat gttgaaagta atcggtatcg gcgacttgat ttatttcagg     2880

agcatatgtt tgaagtattg gaacgggcaa gaaggatgaa ccggacagat tccgaaatat     2940

atgaggatgc tgtagaactt cagcagtttt ttattagaat tcgtgatgaa ctctgcaaaa     3000

atggagagat ccttctttct ccagcactca gctataccac aaaacacttg cataacgatg     3060

tggaaaaaga aaaaaaggaa aaattgccta aagaaataga ggaagataaa ctaaaacgcg     3120

aagaagaaaa aagagaagct gaaaaaagtg aagattcctc aggtactaca ggcctctcag     3180

gcttacatcg tacatacagc caggactgca gctttaagaa cagcatgtat catgtcggag     3240

attatgtcta tgttgaacct gcggaggcca atctacaacc acatatagtg tgtattgaga     3300

gactgtggga ggattcagct ggtgaaaaat ggttgtacgg ctgttggttt tatcggccaa     3360

atgaaacatt ccatttggct acacgaaaat ttctagaaaa agaagttttt aagagtgact     3420

actacaataa agtacctgtt agtaaaattc taggcaaatg tgtagtcatg tttgtcaagg     3480

aatactttaa attatgtcca gaaaactttc gcgatgagga tgtttttgtc tgtgaatcga     3540

ggtattctgc caaaaccaaa tcttttaaga aaattaaact gtggaccatg cccatcagtt     3600

cagttagatt tgtccctcgg gatgtgcctt tgcctgtggt ccgagtggcc tctgtgtttg     3660

caaatgcaga taaaggggat gatgagaaga atacagacaa ctcagatgac aatagagctg     3720

aagacaattt taacttggaa aaggaaaaag aagatgttcc tgtggagatg tccaatggtg     3780

agccaggttg ccactacttt gagcagcttc ggtacaatga catgtggctg aaggttggtg     3840

attgtgtctt catcaaatcc cacggcttgg tgcgccctcg tgtgggcaga attgagaaag     3900

tatgggtccg agatggagct gcatattttt atggccctat cttcattcat ccagaagaaa     3960

cagaacatga gcccacaaaa atgttctaca aaaaagaagt gtttctgagt aatctggaag     4020

agacctgccc tatgagttgt attctgggga aatgtgcagt gctgtcattc aaggacttcc     4080

tctcctgcag gccaactgaa ataccagaaa atgacattct gctttgtgag agccgctata     4140

atgagagtga caagcagatg aagaagttca agggtttgaa gaggttttca ctctctgcta     4200

aagttgtaga tgatgaaatc tactacttca gaaaaccaat cattcctcag aaggaaccct     4260

cacctttgtt agaaaagaag atacaattgc tagaagctaa atttgcagag ttagaaggag     4320

gagatgatga tattgaggag atgggagaag aggatagtga agtcattgaa gctccatctc     4380

tacctcaact gcagacaccc ctggccaatg agttggacct catgccctat acacccccac     4440

agtctacccc aaagtctgcc aaaggcagtg caaagaagga aagttctaaa cgaaaaatca     4500

acatgagtgg ctacattttg ttcagcagtg aaatgagagc tgtgattaaa gcccagcacc     4560

cagactactc ttttggggag ctcagcagac tggtggggac agaatggaga aaccttgaaa     4620

cagccaagaa agcagaatat gaagagcggg cagctaaagt tgctgagcag caggagagag     4680

agcgagcagc acagcaacag cagccgagtg cttctccccg agcaggcacc cctgtggggg     4740

ctctcatggg ggtggtgcca ccaccaacac caatggggat gctcaatcag cagttgacac     4800

ctgttgcagg catgatgggt ggctatccgc caggccttcc acctttgcag ggcccagttg     4860

atggccttgt tagcatgggc agcatgcagc cacttcaccc tggggggcct ccacctcacc     4920

atcttccgcc aggtgtgcct ggcctcccag gcatcccacc accgggtgtg atgaatcaag     4980

gagtagcccc catggtaggg actccagcac caggtggaag tccgtatgga caacaggtag     5040

gagttttggg acctccaggg cagcaggcac cacctccata tcctggtcct catccagctg     5100

gcccccctgt catacagcag ccaacaacgc ccatgtttgt ggctccccca ccaaagaccc     5160

aaaggcttct ccactcagag gcctacctga aatacattga aggactcagt gctgaatcca     5220

acagcattag caagtgggac caaactttgg cagctcgaag acgggatgtc catttgtcca     5280

aagaacagga gagccgccta ccttctcact ggctcaaaag taaaggggca cacaccacca     5340

tggcagatgc cctctggcgc ctacgggatt taatgcttcg agacactctc aacatccgac     5400

aggcatacaa cctagaaaat gtttaatcac atcactgttt cttctgtgga agcaaagagt     5460

tgtggagcgg tagccatttt agttactggg gtgggaggga ggaacaaagg atgataattt     5520

ttattgcatt ttattgtaca tcacacagcc atttttatat aaggacactt ttaataagct     5580

atttcaaatt tggttttgtt acattaagtt gactatcaaa tacacaaaag attttttttg     5640

catatgtttc ctttgtttaa aaccagtttc ataattggtt atatatagta atagttttat     5700

ctttacttgt taaaggactt aaatcatcaa aggttttggc ttggcttagg gttttcgttt     5760

tcttttttat aaatatatat tatatatata tacacatata aaagaaaaaa tgaaaaaaaa     5820

gtttacaaat ttaagttgac aatgaaatgt gaagttggtc ctagtttaca tcttagagga     5880

atgtatatgt atgttttaca tgcctaaata tctgcaggtt ttcttacagg taaagcgaag     5940

tgctttgaaa agtttagatt atacatgtgt gacagatgcg gcatatttgc tctattaaca     6000

cagaggctta ctatagaaat ctaaagtcaa tgctgtacat ccatccagtt agtgtaactg     6060

aagggaaatg taactttgtg ctgagttaga catctgtatt gtcagtgatt cttgtagaat     6120

atgtgctcag atctgagtta tatttagttt tggaaggtaa gttgaagagt acttttgatc     6180

agtttatgat tcagtttatg attttagttt ttgccttcat gttatacatt tatgatttga     6240

aactgtacat ctgttacctt gaaaaacatt gaagaaagta ctgaagtgtg catggaggtg     6300

gtttaagcat aatacttaac ccaagaaaga gtgtaagtgg acacaagctg tgcctgcaca     6360

tagctgtgca gggtagactg cctacataca catggccggg attctttatt tccttgttat     6420

caattatagt gctttgtttg tttcagggtt ggaattctca accagaaata atactttcta     6480

aaatatttta aaattcagct tgtgctttgg attatagaag gaaattatac tttaagaaaa     6540

tgttcacaaa aaaaaaaaaa aaaaaaggac tattacagat cccaatactt ggatttggtg     6600

accttgtctt tctttctttt cttgagacat ggtcctacta ccaaccctgg ctggactgga     6660

gctcagtgta tagaccaggc tagtctcaaa ctctgcctct tcctcccaag tgctgggatt     6720

aagggcaggt accatagtgc tcagcaacca caaccctgtc tttccaacac ggccctagcg     6780

taagcactga ggcagtgtgc agtgctcagg cagcagcaaa catttcccgg gggtggtttt     6840

gaacctgctt gggtggttgt gtggtgctga cgctgccact gccctgttgt tcattgagaa     6900

tgattgttaa atgacactct tcctttagaa tataacggat cagtactcat gtttaattgc     6960

catgcttaat aaatcatgag aacaaaagag tatagaatgg aaagcattcc ctggtagcta     7020

ctttaaatac aggagccctg taacttaata ccagtagtca accactggat ctcagttttc     7080

atcaagtatt ttaaataaat aatcttaaat tttaaaatac gtactgcaga gtatgccagt     7140

atcttattgt taaaactgaa tcaaataaat cttcgattcc tggttatttg gaccattgac     7200

tcatcatgga ctatataatg taataagatt cttttctctt aaggtatcct tgaattacac     7260

caaagaacca gaaacttaat tttggttaaa ttatttattt atttcatgca ttaattttct     7320

ttttcttttt aaaggtttag atgaggctcc ttagggagtc tctaaaaccg cttcactatc     7380

agcaaccagg agtactagaa gccagagcac tcttcctcct ggctcctccc cagtgctcta     7440

gtgctgtagg aaccaagagc cagccccagg ttccccgagg cagtaaaaat ccagcacagg     7500

gggctgtgtc cctaaggcaa gccctgatta cctttaaaaa aaaccaaaaa aacaaacaaa     7560

aaaaaaaaac ctaattaact aaagcattta aggcactatt tattttagaa tcatgctttt     7620

gaagagcatc agtgattact tagggtgtaa tatgtaaaga tcagacatct ccaaaaacag     7680

aaaaagtaca agtaaacaac acactttctc atgactttta agaactgtag taatgtggct     7740

taggaaatat aatggcctaa ttgttttcaa aatgtaagtt cctgtgaaga attttgttta     7800

tattgggttg gggacctata ggtttaaaat agaatgtcag tcagctgact taaaaaacat     7860

tggttttact aagtctgcct tccccttcta aggaagaact gagtgggtaa gggacaggtg     7920

tgtaaaatct ccaaatggat gttacagctt tcagcttgaa cgtttgtttc cagacctgat     7980

taaaatttgg tttattctaa tttctgtact atatcatctg aggttttaag tggtaactgg     8040

ttctatacca tgtatgtatc atatgtttgt tcatcaaagc tttttaatcc aaataaaaac     8100

aacagtttgc aaagtga                                                    8117


<210>  6
<211>  1704
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Ser Lys Arg Arg Arg Ala Thr Ser Pro Ser Ser Ser Val Ser 
1               5                   10                  15      


Gly Asp Phe Asp Asp Gly His His Ser Val Pro Thr Pro Gly Pro Ser 
            20                  25                  30          


Arg Lys Arg Arg Arg Leu Ser Asn Leu Pro Thr Val Asp Pro Ile Ala 
        35                  40                  45              


Val Cys His Glu Leu Tyr Asn Thr Ile Arg Asp Tyr Lys Asp Glu Gln 
    50                  55                  60                  


Gly Arg Leu Leu Cys Glu Leu Phe Ile Arg Ala Pro Lys Arg Arg Asn 
65                  70                  75                  80  


Gln Pro Asp Tyr Tyr Glu Val Val Ser Gln Pro Ile Asp Leu Met Lys 
                85                  90                  95      


Ile Gln Gln Lys Leu Lys Met Glu Glu Tyr Asp Asp Val Asn Leu Leu 
            100                 105                 110         


Thr Ala Asp Phe Gln Leu Leu Phe Asn Asn Ala Lys Ala Tyr Tyr Lys 
        115                 120                 125             


Pro Asp Ser Pro Glu Tyr Lys Ala Ala Cys Lys Leu Trp Asp Leu Tyr 
    130                 135                 140                 


Leu Arg Thr Arg Asn Glu Phe Val Gln Lys Gly Glu Ala Asp Asp Glu 
145                 150                 155                 160 


Asp Asp Asp Glu Asp Gly Gln Asp Asn Gln Gly Thr Leu Ala Asp Gly 
                165                 170                 175     


Ser Ser Pro Gly Tyr Leu Lys Glu Ile Leu Glu Gln Leu Leu Glu Ala 
            180                 185                 190         


Ile Val Val Ala Thr Asn Pro Ser Gly Arg Leu Ile Ser Glu Leu Phe 
        195                 200                 205             


Gln Lys Leu Pro Ser Lys Val Gln Tyr Pro Asp Tyr Tyr Ala Ile Ile 
    210                 215                 220                 


Lys Glu Pro Ile Asp Leu Lys Thr Ile Ala Gln Arg Ile Gln Asn Gly 
225                 230                 235                 240 


Ser Tyr Lys Ser Ile His Ala Met Ala Lys Asp Ile Asp Leu Leu Ala 
                245                 250                 255     


Lys Asn Ala Lys Thr Tyr Asn Glu Pro Gly Ser Gln Val Phe Lys Asp 
            260                 265                 270         


Ala Asn Ser Ile Lys Lys Ile Phe Tyr Met Lys Lys Ala Glu Ile Glu 
        275                 280                 285             


His His Glu Met Thr Lys Ser Ser Leu Arg Ile Arg Thr Ala Ser Asn 
    290                 295                 300                 


Leu Ala Ala Ala Arg Leu Thr Gly Pro Ser His Asn Lys Ser Ser Leu 
305                 310                 315                 320 


Gly Glu Glu Arg Asn Pro Thr Ser Lys Tyr Tyr Arg Asn Lys Arg Ala 
                325                 330                 335     


Val Gln Gly Gly Arg Leu Ser Ala Ile Thr Met Ala Leu Gln Tyr Gly 
            340                 345                 350         


Ser Glu Ser Glu Glu Asp Ala Ala Leu Ala Ala Ala Arg Tyr Glu Glu 
        355                 360                 365             


Gly Glu Ser Glu Ala Glu Ser Ile Thr Ser Phe Met Asp Val Ser Asn 
    370                 375                 380                 


Pro Phe His Gln Leu Tyr Asp Thr Val Arg Ser Cys Arg Asn His Gln 
385                 390                 395                 400 


Gly Gln Leu Ile Ala Glu Pro Phe Phe His Leu Pro Ser Lys Lys Lys 
                405                 410                 415     


Tyr Pro Asp Tyr Tyr Gln Gln Ile Lys Met Pro Ile Ser Leu Gln Gln 
            420                 425                 430         


Ile Arg Thr Lys Leu Lys Asn Gln Glu Tyr Glu Thr Leu Asp His Leu 
        435                 440                 445             


Glu Cys Asp Leu Asn Leu Met Phe Glu Asn Ala Lys Arg Tyr Asn Val 
    450                 455                 460                 


Pro Asn Ser Ala Ile Tyr Lys Arg Val Leu Lys Leu Gln Gln Val Met 
465                 470                 475                 480 


Gln Ala Lys Lys Lys Glu Leu Ala Arg Arg Asp Asp Ile Glu Asp Gly 
                485                 490                 495     


Asp Ser Met Ile Ser Ser Ala Thr Ser Asp Thr Gly Ser Ala Lys Arg 
            500                 505                 510         


Lys Arg Asn Thr His Asp Ser Glu Met Leu Gly Leu Arg Arg Leu Ser 
        515                 520                 525             


Ser Lys Lys Asn Ile Arg Lys Gln Arg Met Lys Ile Leu Phe Asn Val 
    530                 535                 540                 


Val Leu Glu Ala Arg Glu Pro Gly Ser Gly Arg Arg Leu Cys Asp Leu 
545                 550                 555                 560 


Phe Met Val Lys Pro Ser Lys Lys Asp Tyr Pro Asp Tyr Tyr Lys Ile 
                565                 570                 575     


Ile Leu Glu Pro Met Asp Leu Lys Ile Ile Glu His Asn Ile Arg Asn 
            580                 585                 590         


Asp Lys Tyr Ala Gly Glu Glu Gly Met Met Glu Asp Met Lys Leu Met 
        595                 600                 605             


Phe Arg Asn Ala Arg His Tyr Asn Glu Glu Gly Ser Gln Val Tyr Asn 
    610                 615                 620                 


Asp Ala His Ile Leu Glu Lys Leu Leu Lys Asp Lys Arg Lys Glu Leu 
625                 630                 635                 640 


Gly Pro Leu Pro Asp Asp Asp Asp Met Ala Ser Pro Lys Leu Lys Leu 
                645                 650                 655     


Ser Arg Lys Ser Gly Val Ser Pro Lys Lys Ser Lys Tyr Met Thr Pro 
            660                 665                 670         


Met Gln Gln Lys Leu Asn Glu Val Tyr Glu Ala Val Lys Asn Tyr Thr 
        675                 680                 685             


Asp Lys Arg Gly Arg Arg Leu Ser Ala Ile Phe Leu Arg Leu Pro Ser 
    690                 695                 700                 


Arg Ser Glu Leu Pro Asp Tyr Tyr Leu Thr Ile Lys Lys Pro Met Asp 
705                 710                 715                 720 


Met Glu Lys Ile Arg Ser His Met Met Ala Asn Lys Tyr Gln Asp Ile 
                725                 730                 735     


Asp Ser Met Val Glu Asp Phe Val Met Met Phe Asn Asn Ala Cys Thr 
            740                 745                 750         


Tyr Asn Glu Pro Glu Ser Leu Ile Tyr Lys Asp Ala Leu Val Leu His 
        755                 760                 765             


Lys Val Leu Leu Glu Thr Arg Arg Asp Leu Glu Gly Asp Glu Asp Ser 
    770                 775                 780                 


His Val Pro Asn Val Thr Leu Leu Ile Gln Glu Leu Ile His Asn Leu 
785                 790                 795                 800 


Phe Val Ser Val Met Ser His Gln Asp Asp Glu Gly Arg Cys Tyr Ser 
                805                 810                 815     


Asp Ser Leu Ala Glu Ile Pro Ala Val Asp Pro Asn Ser Pro Asn Lys 
            820                 825                 830         


Pro Pro Leu Thr Phe Asp Ile Ile Arg Lys Asn Val Glu Ser Asn Arg 
        835                 840                 845             


Tyr Arg Arg Leu Asp Leu Phe Gln Glu His Met Phe Glu Val Leu Glu 
    850                 855                 860                 


Arg Ala Arg Arg Met Asn Arg Thr Asp Ser Glu Ile Tyr Glu Asp Ala 
865                 870                 875                 880 


Val Glu Leu Gln Gln Phe Phe Ile Arg Ile Arg Asp Glu Leu Cys Lys 
                885                 890                 895     


Asn Gly Glu Ile Leu Leu Ser Pro Ala Leu Ser Tyr Thr Thr Lys His 
            900                 905                 910         


Leu His Asn Asp Val Glu Lys Glu Lys Lys Glu Lys Leu Pro Lys Glu 
        915                 920                 925             


Ile Glu Glu Asp Lys Leu Lys Arg Glu Glu Glu Lys Arg Glu Ala Glu 
    930                 935                 940                 


Lys Ser Glu Asp Ser Ser Gly Thr Thr Gly Leu Ser Gly Leu His Arg 
945                 950                 955                 960 


Thr Tyr Ser Gln Asp Cys Ser Phe Lys Asn Ser Met Tyr His Val Gly 
                965                 970                 975     


Asp Tyr Val Tyr Val Glu Pro Ala Glu Ala Asn Leu Gln Pro His Ile 
            980                 985                 990         


Val Cys Ile Glu Arg Leu Trp Glu  Asp Ser Ala Gly Glu  Lys Trp Leu 
        995                 1000                 1005             


Tyr Gly  Cys Trp Phe Tyr Arg  Pro Asn Glu Thr Phe  His Leu Ala 
    1010                 1015                 1020             


Thr Arg  Lys Phe Leu Glu Lys  Glu Val Phe Lys Ser  Asp Tyr Tyr 
    1025                 1030                 1035             


Asn Lys  Val Pro Val Ser Lys  Ile Leu Gly Lys Cys  Val Val Met 
    1040                 1045                 1050             


Phe Val  Lys Glu Tyr Phe Lys  Leu Cys Pro Glu Asn  Phe Arg Asp 
    1055                 1060                 1065             


Glu Asp  Val Phe Val Cys Glu  Ser Arg Tyr Ser Ala  Lys Thr Lys 
    1070                 1075                 1080             


Ser Phe  Lys Lys Ile Lys Leu  Trp Thr Met Pro Ile  Ser Ser Val 
    1085                 1090                 1095             


Arg Phe  Val Pro Arg Asp Val  Pro Leu Pro Val Val  Arg Val Ala 
    1100                 1105                 1110             


Ser Val  Phe Ala Asn Ala Asp  Lys Gly Asp Asp Glu  Lys Asn Thr 
    1115                 1120                 1125             


Asp Asn  Ser Asp Asp Asn Arg  Ala Glu Asp Asn Phe  Asn Leu Glu 
    1130                 1135                 1140             


Lys Glu  Lys Glu Asp Val Pro  Val Glu Met Ser Asn  Gly Glu Pro 
    1145                 1150                 1155             


Gly Cys  His Tyr Phe Glu Gln  Leu Arg Tyr Asn Asp  Met Trp Leu 
    1160                 1165                 1170             


Lys Val  Gly Asp Cys Val Phe  Ile Lys Ser His Gly  Leu Val Arg 
    1175                 1180                 1185             


Pro Arg  Val Gly Arg Ile Glu  Lys Val Trp Val Arg  Asp Gly Ala 
    1190                 1195                 1200             


Ala Tyr  Phe Tyr Gly Pro Ile  Phe Ile His Pro Glu  Glu Thr Glu 
    1205                 1210                 1215             


His Glu  Pro Thr Lys Met Phe  Tyr Lys Lys Glu Val  Phe Leu Ser 
    1220                 1225                 1230             


Asn Leu  Glu Glu Thr Cys Pro  Met Ser Cys Ile Leu  Gly Lys Cys 
    1235                 1240                 1245             


Ala Val  Leu Ser Phe Lys Asp  Phe Leu Ser Cys Arg  Pro Thr Glu 
    1250                 1255                 1260             


Ile Pro  Glu Asn Asp Ile Leu  Leu Cys Glu Ser Arg  Tyr Asn Glu 
    1265                 1270                 1275             


Ser Asp  Lys Gln Met Lys Lys  Phe Lys Gly Leu Lys  Arg Phe Ser 
    1280                 1285                 1290             


Leu Ser  Ala Lys Val Val Asp  Asp Glu Ile Tyr Tyr  Phe Arg Lys 
    1295                 1300                 1305             


Pro Ile  Ile Pro Gln Lys Glu  Pro Ser Pro Leu Leu  Glu Lys Lys 
    1310                 1315                 1320             


Ile Gln  Leu Leu Glu Ala Lys  Phe Ala Glu Leu Glu  Gly Gly Asp 
    1325                 1330                 1335             


Asp Asp  Ile Glu Glu Met Gly  Glu Glu Asp Ser Glu  Val Ile Glu 
    1340                 1345                 1350             


Ala Pro  Ser Leu Pro Gln Leu  Gln Thr Pro Leu Ala  Asn Glu Leu 
    1355                 1360                 1365             


Asp Leu  Met Pro Tyr Thr Pro  Pro Gln Ser Thr Pro  Lys Ser Ala 
    1370                 1375                 1380             


Lys Gly  Ser Ala Lys Lys Glu  Ser Ser Lys Arg Lys  Ile Asn Met 
    1385                 1390                 1395             


Ser Gly  Tyr Ile Leu Phe Ser  Ser Glu Met Arg Ala  Val Ile Lys 
    1400                 1405                 1410             


Ala Gln  His Pro Asp Tyr Ser  Phe Gly Glu Leu Ser  Arg Leu Val 
    1415                 1420                 1425             


Gly Thr  Glu Trp Arg Asn Leu  Glu Thr Ala Lys Lys  Ala Glu Tyr 
    1430                 1435                 1440             


Glu Glu  Arg Ala Ala Lys Val  Ala Glu Gln Gln Glu  Arg Glu Arg 
    1445                 1450                 1455             


Ala Ala  Gln Gln Gln Gln Pro  Ser Ala Ser Pro Arg  Ala Gly Thr 
    1460                 1465                 1470             


Pro Val  Gly Ala Leu Met Gly  Val Val Pro Pro Pro  Thr Pro Met 
    1475                 1480                 1485             


Gly Met  Leu Asn Gln Gln Leu  Thr Pro Val Ala Gly  Met Met Gly 
    1490                 1495                 1500             


Gly Tyr  Pro Pro Gly Leu Pro  Pro Leu Gln Gly Pro  Val Asp Gly 
    1505                 1510                 1515             


Leu Val  Ser Met Gly Ser Met  Gln Pro Leu His Pro  Gly Gly Pro 
    1520                 1525                 1530             


Pro Pro  His His Leu Pro Pro  Gly Val Pro Gly Leu  Pro Gly Ile 
    1535                 1540                 1545             


Pro Pro  Pro Gly Val Met Asn  Gln Gly Val Ala Pro  Met Val Gly 
    1550                 1555                 1560             


Thr Pro  Ala Pro Gly Gly Ser  Pro Tyr Gly Gln Gln  Val Gly Val 
    1565                 1570                 1575             


Leu Gly  Pro Pro Gly Gln Gln  Ala Pro Pro Pro Tyr  Pro Gly Pro 
    1580                 1585                 1590             


His Pro  Ala Gly Pro Pro Val  Ile Gln Gln Pro Thr  Thr Pro Met 
    1595                 1600                 1605             


Phe Val  Ala Pro Pro Pro Lys  Thr Gln Arg Leu Leu  His Ser Glu 
    1610                 1615                 1620             


Ala Tyr  Leu Lys Tyr Ile Glu  Gly Leu Ser Ala Glu  Ser Asn Ser 
    1625                 1630                 1635             


Ile Ser  Lys Trp Asp Gln Thr  Leu Ala Ala Arg Arg  Arg Asp Val 
    1640                 1645                 1650             


His Leu  Ser Lys Glu Gln Glu  Ser Arg Leu Pro Ser  His Trp Leu 
    1655                 1660                 1665             


Lys Ser  Lys Gly Ala His Thr  Thr Met Ala Asp Ala  Leu Trp Arg 
    1670                 1675                 1680             


Leu Arg  Asp Leu Met Leu Arg  Asp Thr Leu Asn Ile  Arg Gln Ala 
    1685                 1690                 1695             


Tyr Asn  Leu Glu Asn Val 
    1700                 


<210>  7
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7
tcatcatcta ccactttagc a                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  8
tcatcatcta ccactttagc a                                                 21


<210>  9
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  9
atgagagtcc t                                                            11


<210>  10
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  10
atgagagtcc t                                                            11


<210>  11
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  11
ggcggcggcg gc                                                           12


<210>  12
<211>  12
<212>  DNA
<213>  Homo sapiens

<400>  12
ggcggcggcg gc                                                           12


<210>  13
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  13
tcatcatcta ccactttagc a                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  14
tcatcatcta ccactttagc a                                                 21


<210>  15
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  15
atgagagtcc t                                                            11


<210>  16
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  16
atgagagtcc t                                                            11