                         SEQUENCE LISTING

<110>  Chr. Hansen A/S
 
<120>  Process for producing a fermented milk product

<130>  P6170PC00

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1931
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  1

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ala Val Glu Asp Ala 
            20                  25                  30          


Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr Pro Glu Val Ala 
        35                  40                  45              


Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp 
    50                  55                  60                  


Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro 
65                  70                  75                  80  


Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr 
                85                  90                  95      


Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr 
            100                 105                 110         


Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg 
        115                 120                 125             


Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met 
    130                 135                 140                 


Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr 
145                 150                 155                 160 


Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly 
                165                 170                 175     


Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser 
            180                 185                 190         


Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val 
        195                 200                 205             


Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro 
    210                 215                 220                 


Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met Asn Leu Thr Thr 
225                 230                 235                 240 


Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile Thr Leu Lys Gln 
                245                 250                 255     


Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val 
            260                 265                 270         


Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr 
        275                 280                 285             


Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro 
    290                 295                 300                 


Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu 
305                 310                 315                 320 


Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala 
                325                 330                 335     


Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val 
            340                 345                 350         


Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg 
        355                 360                 365             


Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser 
    370                 375                 380                 


Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys 
385                 390                 395                 400 


Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe Asp Met Trp Asn 
                405                 410                 415     


Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln 
            420                 425                 430         


Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr 
        435                 440                 445             


Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala 
    450                 455                 460                 


Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile 
465                 470                 475                 480 


Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala Lys Leu Val Ala 
                485                 490                 495     


Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn 
            500                 505                 510         


Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu 
        515                 520                 525             


Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn 
    530                 535                 540                 


Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser 
545                 550                 555                 560 


Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr 
                565                 570                 575     


Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser 
            580                 585                 590         


Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val 
        595                 600                 605             


Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr 
    610                 615                 620                 


Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly 
625                 630                 635                 640 


Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile Val Asp Thr Ala 
                645                 650                 655     


Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp 
            660                 665                 670         


Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn Glu Asn Val Val 
        675                 680                 685             


Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala 
    690                 695                 700                 


Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser Thr Glu Lys Arg 
705                 710                 715                 720 


Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr 
                725                 730                 735     


Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser Thr Ala His Lys 
            740                 745                 750         


Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser 
        755                 760                 765             


Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr 
    770                 775                 780                 


Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys 
785                 790                 795                 800 


Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser 
                805                 810                 815     


Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His Ile Val Pro Asp 
            820                 825                 830         


Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val 
        835                 840                 845             


Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp 
    850                 855                 860                 


Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr 
865                 870                 875                 880 


Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln 
                885                 890                 895     


Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr 
            900                 905                 910         


Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys 
        915                 920                 925             


Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser 
    930                 935                 940                 


Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp 
945                 950                 955                 960 


Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala 
                965                 970                 975     


Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp Glu Ile Gly Ala 
            980                 985                 990         


Leu Leu Asn Tyr Ser Ala Ser Thr  Pro Val Gly Thr Pro  Ala Val Leu 
        995                 1000                 1005             


Pro Gly  Ser Arg Pro Ala Val  Leu Pro Asp Gly Thr  Val Thr Ser 
    1010                 1015                 1020             


Ala Asn  Phe Ala Val His Trp  Thr Lys Pro Ala Asp  Thr Val Tyr 
    1025                 1030                 1035             


Asn Thr  Ala Gly Thr Val Lys  Val Pro Gly Thr Ala  Thr Val Phe 
    1040                 1045                 1050             


Gly Lys  Glu Phe Lys Val Thr  Ala Thr Ile Arg Val  Gln Arg Ser 
    1055                 1060                 1065             


Gln Val  Thr Ile Gly Ser Ser  Val Ser Gly Asn Ala  Leu Arg Leu 
    1070                 1075                 1080             


Thr Gln  Asn Ile Pro Ala Asp  Lys Gln Ser Asp Thr  Leu Asp Ala 
    1085                 1090                 1095             


Ile Lys  Asp Gly Ser Thr Thr  Val Asp Ala Asn Thr  Gly Gly Gly 
    1100                 1105                 1110             


Ala Asn  Pro Ser Ala Trp Thr  Asn Trp Ala Tyr Ser  Lys Ala Gly 
    1115                 1120                 1125             


His Asn  Thr Ala Glu Ile Thr  Phe Glu Tyr Ala Thr  Glu Gln Gln 
    1130                 1135                 1140             


Leu Gly  Gln Ile Val Met Tyr  Phe Phe Arg Asp Ser  Asn Ala Val 
    1145                 1150                 1155             


Arg Phe  Pro Asp Ala Gly Lys  Thr Lys Ile Gln Ile  Ser Ala Asp 
    1160                 1165                 1170             


Gly Lys  Asn Trp Thr Asp Leu  Ala Ala Thr Glu Thr  Ile Ala Ala 
    1175                 1180                 1185             


Gln Glu  Ser Ser Asp Arg Val  Lys Pro Tyr Thr Tyr  Asp Phe Ala 
    1190                 1195                 1200             


Pro Val  Gly Ala Thr Phe Val  Lys Val Thr Val Thr  Asn Ala Asp 
    1205                 1210                 1215             


Thr Thr  Thr Pro Ser Gly Val  Val Cys Ala Gly Leu  Thr Glu Ile 
    1220                 1225                 1230             


Glu Leu  Lys Thr Ala Thr Ser  Lys Phe Val Thr Asn  Thr Ser Ala 
    1235                 1240                 1245             


Ala Leu  Ser Ser Leu Thr Val  Asn Gly Thr Lys Val  Ser Asp Ser 
    1250                 1255                 1260             


Val Leu  Ala Ala Gly Ser Tyr  Asn Thr Pro Ala Ile  Ile Ala Asp 
    1265                 1270                 1275             


Val Lys  Ala Glu Gly Glu Gly  Asn Ala Ser Val Thr  Val Leu Pro 
    1280                 1285                 1290             


Ala His  Asp Asn Val Ile Arg  Val Ile Thr Glu Ser  Glu Asp His 
    1295                 1300                 1305             


Val Thr  Arg Lys Thr Phe Thr  Ile Asn Leu Gly Thr  Glu Gln Glu 
    1310                 1315                 1320             


Phe Pro  Ala Asp Ser Asp Glu  Arg Asp Tyr Pro Ala  Ala Asp Met 
    1325                 1330                 1335             


Thr Val  Thr Val Gly Ser Glu  Gln Thr Ser Gly Thr  Ala Thr Glu 
    1340                 1345                 1350             


Gly Pro  Lys Lys Phe Ala Val  Asp Gly Asn Thr Ser  Thr Tyr Trp 
    1355                 1360                 1365             


His Ser  Asn Trp Thr Pro Thr  Thr Val Asn Asp Leu  Trp Ile Ala 
    1370                 1375                 1380             


Phe Glu  Leu Gln Lys Pro Thr  Lys Leu Asp Ala Leu  Arg Tyr Leu 
    1385                 1390                 1395             


Pro Arg  Pro Ala Gly Ser Lys  Asn Gly Ser Val Thr  Glu Tyr Lys 
    1400                 1405                 1410             


Val Gln  Val Ser Asp Asp Gly  Thr Asn Trp Thr Asp  Ala Gly Ser 
    1415                 1420                 1425             


Gly Thr  Trp Thr Thr Asp Tyr  Gly Trp Lys Leu Ala  Glu Phe Asn 
    1430                 1435                 1440             


Gln Pro  Val Thr Thr Lys His  Val Arg Leu Lys Ala  Val His Thr 
    1445                 1450                 1455             


Tyr Ala  Asp Ser Gly Asn Asp  Lys Phe Met Ser Ala  Ser Glu Ile 
    1460                 1465                 1470             


Arg Leu  Arg Lys Ala Val Asp  Thr Thr Asp Ile Ser  Gly Ala Thr 
    1475                 1480                 1485             


Val Thr  Val Pro Ala Lys Leu  Thr Val Asp Arg Val  Asp Ala Asp 
    1490                 1495                 1500             


His Pro  Ala Thr Phe Ala Thr  Lys Asp Val Thr Val  Thr Leu Gly 
    1505                 1510                 1515             


Asp Ala  Thr Leu Arg Tyr Gly  Val Asp Tyr Leu Leu  Asp Tyr Ala 
    1520                 1525                 1530             


Gly Asn  Thr Ala Val Gly Lys  Ala Thr Val Thr Val  Arg Gly Ile 
    1535                 1540                 1545             


Asp Lys  Tyr Ser Gly Thr Val  Ala Lys Thr Phe Thr  Ile Glu Leu 
    1550                 1555                 1560             


Lys Asn  Ala Pro Ala Pro Glu  Pro Thr Leu Thr Ser  Val Ser Val 
    1565                 1570                 1575             


Lys Thr  Lys Pro Ser Lys Leu  Thr Tyr Val Val Gly  Asp Ala Phe 
    1580                 1585                 1590             


Asp Pro  Ala Gly Leu Val Leu  Gln Leu Asn Tyr Asp  Asp Asp Ser 
    1595                 1600                 1605             


Thr Gly  Thr Val Thr Trp Asn  Thr Gln Thr Ala Gly  Asp Phe Thr 
    1610                 1615                 1620             


Phe Lys  Pro Ala Leu Asp Ala  Lys Leu Lys Val Thr  Asp Lys Thr 
    1625                 1630                 1635             


Val Thr  Val Thr Tyr Gln Gly  Lys Ser Ala Val Ile  Asp Ile Thr 
    1640                 1645                 1650             


Val Ser  Gln Pro Ala Pro Thr  Val Ser Lys Thr Asp  Leu Asp Lys 
    1655                 1660                 1665             


Ala Ile  Lys Ala Ile Glu Ala  Lys Asn Pro Asp Ser  Ser Lys Tyr 
    1670                 1675                 1680             


Thr Ala  Asp Ser Trp Lys Thr  Phe Ala Asp Ala Met  Ala His Ala 
    1685                 1690                 1695             


Lys Ala  Val Ile Ala Asp Asp  Ser Ala Thr Gln Gln  Asp Val Asp 
    1700                 1705                 1710             


Asn Ala  Leu Lys Ala Leu Thr  Asp Ala Tyr Ala Gly  Leu Thr Glu 
    1715                 1720                 1725             


Lys Thr  Pro Glu Pro Ala Pro  Val Ser Lys Ser Glu  Leu Asp Lys 
    1730                 1735                 1740             


Lys Ile  Lys Ala Ile Glu Ala  Glu Lys Leu Asp Gly  Ser Lys Tyr 
    1745                 1750                 1755             


Thr Ala  Glu Ser Trp Lys Ala  Phe Glu Thr Ala Leu  Ala His Ala 
    1760                 1765                 1770             


Lys Ala  Val Ile Ala Ser Asp  Ser Ala Thr Gln Gln  Asn Val Asp 
    1775                 1780                 1785             


Ala Ala  Leu Gly Ala Leu Thr  Ser Ala Arg Asp Gly  Leu Thr Glu 
    1790                 1795                 1800             


Lys Gly  Glu Val Lys Pro Asp  Pro Lys Pro Glu Pro  Gly Thr Val 
    1805                 1810                 1815             


Asp Lys  Ala Ala Leu Asp Lys  Ala Val Lys Lys Val  Glu Ala Glu 
    1820                 1825                 1830             


Lys Leu  Asp Gly Ser Lys Tyr  Thr Ala Asp Ser Trp  Lys Ala Phe 
    1835                 1840                 1845             


Glu Thr  Ala Leu Ala His Ala  Lys Ala Val Ile Gly  Asn Ala Asn 
    1850                 1855                 1860             


Ser Thr  Gln Phe Asp Ile Asp  Asn Ala Leu Ser Met  Leu Asn Asp 
    1865                 1870                 1875             


Ala Arg  Ala Ala Leu Lys Glu  Lys Pro Gly Arg Ile  Ile Ala Ile 
    1880                 1885                 1890             


Ile Asp  Gly Ser Ala Leu Ser  Lys Thr Gly Ala Ser  Val Ala Ile 
    1895                 1900                 1905             


Ile Ala  Ser Val Ala Ala Ala  Met Leu Ala Val Gly  Ala Gly Val 
    1910                 1915                 1920             


Met Ala  Leu Arg Arg Lys Arg  Ser 
    1925                 1930     


<210>  2
<211>  1341
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  2

Met Lys Lys Pro Leu Gly Lys Ile Val Ala Ser Thr Ala Leu Leu Ile 
1               5                   10                  15      


Ser Val Ala Phe Ser Ser Ser Ile Ala Ser Ala Ile Glu Asp Ala Thr 
            20                  25                  30          


Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr Pro Glu Val Ala Tyr 
        35                  40                  45              


Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr Ser Asp Phe Asp Ala 
    50                  55                  60                  


Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln Ala Gln Asp Pro Ala 
65                  70                  75                  80  


Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu Pro His Asp Tyr Ser 
                85                  90                  95      


Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala Glu Ser Ala Tyr Leu 
            100                 105                 110         


Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe Thr Ile Asp Arg Asp 
        115                 120                 125             


Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp Gly Val Tyr Met Asn 
    130                 135                 140                 


Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly Thr His Pro Tyr Gly 
145                 150                 155                 160 


Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn Ala Lys Phe Gly Gly 
                165                 170                 175     


Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg Leu Pro Ser Ser Arg 
            180                 185                 190         


Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Thr Val Thr 
        195                 200                 205             


Asp Gly Val His Val Gly Asn Asn Gly Val Ala Ile Lys Thr Pro Ser 
    210                 215                 220                 


Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met Asn Leu Thr Thr Lys 
225                 230                 235                 240 


Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile Thr Leu Lys Gln Thr 
                245                 250                 255     


Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala Ile Gly Thr Val Thr 
            260                 265                 270         


Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser Ala Asp Val Thr Ser 
        275                 280                 285             


Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser Ile Lys Asn Pro Asn 
    290                 295                 300                 


Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly Gly Lys Val Leu Asp 
305                 310                 315                 320 


Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr Gly Phe Asp Ala Thr 
                325                 330                 335     


Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys Leu Lys Gly Val Ser 
            340                 345                 350         


Met His His Asp Gln Gly Ser Leu Gly Ala Val Ala Asn Arg Arg Ala 
        355                 360                 365             


Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met Gly Val Asn Ser Ile 
    370                 375                 380                 


Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu Ile Asp Val Cys Asn 
385                 390                 395                 400 


Glu Lys Gly Val Leu Val Val Glu Glu Val Phe Asp Met Trp Asn Arg 
                405                 410                 415     


Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys Trp Phe Gly Gln Ala 
            420                 425                 430         


Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp Lys Asp Glu Thr Trp 
        435                 440                 445             


Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg Asp Arg Asn Ala Pro 
    450                 455                 460                 


Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met Met Glu Gly Ile Ser 
465                 470                 475                 480 


Gly Ser Val Ser Gly Phe Ser Ala Thr Ser Ala Lys Leu Val Ala Trp 
                485                 490                 495     


Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr Tyr Gly Asp Asn Lys 
            500                 505                 510         


Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met Gly Asp Asn Leu Thr 
        515                 520                 525             


Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser Asp Gly Ala Asn Tyr 
    530                 535                 540                 


Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala Ile Tyr Gly Ser Glu 
545                 550                 555                 560 


Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr Asn Arg Thr Thr Gly 
                565                 570                 575     


Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser Tyr Asp Asn Ser Ala 
            580                 585                 590         


Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp Tyr Asp Val Val Gln 
        595                 600                 605             


Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr Gly Phe Asp Tyr Leu 
    610                 615                 620                 


Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser Gly Ala Val Gly Ser 
625                 630                 635                 640 


Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile Val Asp Thr Ala Gly 
                645                 650                 655     


Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser Gln Trp Asn Asp Asp 
            660                 665                 670         


Val His Thr Leu His Ile Leu Pro Ala Trp Asn Glu Asn Val Val Ala 
        675                 680                 685             


Lys Gly Ser Gly Asn Asn Val Pro Val Val Val Tyr Thr Asp Ala Ala 
    690                 695                 700                 


Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser Thr Glu Gln Arg Leu 
705                 710                 715                 720 


Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr Ala Ala Gly Tyr Thr 
                725                 730                 735     


Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser Thr Ala His Lys Asn 
            740                 745                 750         


Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu Gly Thr Ile Ser Ala 
        755                 760                 765             


Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro Glu Gly Ser Thr Glu 
    770                 775                 780                 


Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala Ala Lys Leu Lys Ala 
785                 790                 795                 800 


Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly Lys Asp Leu Ser Tyr 
                805                 810                 815     


Ile Glu Val Asp Val Thr Asp Ala Asn Gly His Ile Val Pro Asp Ala 
            820                 825                 830         


Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala Gly Lys Leu Val Gly 
        835                 840                 845             


Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser Tyr Gln Ala Asp Asn 
    850                 855                 860                 


Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile Val Gln Ser Thr Lys 
865                 870                 875                 880 


Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala Asp Gly Leu Gln Ser 
                885                 890                 895     


Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro Gly Thr Ser Thr Glu 
            900                 905                 910         


Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn Tyr Tyr Val Lys Thr 
        915                 920                 925             


Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu Val Arg Tyr Ser Asp 
    930                 935                 940                 


Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp Ala Val Ser Asp Asp 
945                 950                 955                 960 


Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala Gly Thr Val Ala Gly 
                965                 970                 975     


Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp Glu Ile Gly Ala Leu 
            980                 985                 990         


Leu Asn Tyr Ser Ala Ser Thr Pro  Val Gly Thr Pro Ala  Val Leu Pro 
        995                 1000                 1005             


Gly Ser  Arg Pro Ala Val Leu  Pro Asp Gly Thr Val  Thr Ser Ala 
    1010                 1015                 1020             


Asn Phe  Ala Val His Trp Thr  Lys Pro Ala Asp Thr  Val Tyr Asn 
    1025                 1030                 1035             


Thr Ala  Gly Thr Val Lys Val  Pro Gly Thr Ala Thr  Val Phe Gly 
    1040                 1045                 1050             


Lys Glu  Phe Lys Val Thr Ala  Thr Ile Arg Val Gln  Arg Ser Gln 
    1055                 1060                 1065             


Val Thr  Ile Gly Ser Ser Val  Ser Gly Asn Ala Leu  Arg Leu Thr 
    1070                 1075                 1080             


Gln Asn  Ile Pro Ala Asp Lys  Gln Ser Asp Thr Leu  Asp Ala Ile 
    1085                 1090                 1095             


Lys Asp  Gly Ser Thr Thr Val  Asp Ala Asn Thr Gly  Gly Gly Ala 
    1100                 1105                 1110             


Asn Pro  Ser Ala Trp Thr Asn  Trp Ala Tyr Ser Lys  Ala Gly His 
    1115                 1120                 1125             


Asn Thr  Ala Glu Ile Thr Phe  Glu Tyr Ala Thr Glu  Gln Gln Leu 
    1130                 1135                 1140             


Gly Gln  Ile Val Met Tyr Phe  Phe Arg Asp Ser Asn  Ala Val Arg 
    1145                 1150                 1155             


Phe Pro  Asp Ala Gly Lys Thr  Lys Ile Gln Ile Ser  Ala Asp Gly 
    1160                 1165                 1170             


Lys Asn  Trp Thr Asp Leu Ala  Ala Thr Glu Thr Ile  Ala Ala Gln 
    1175                 1180                 1185             


Glu Ser  Ser Asp Arg Val Lys  Pro Tyr Thr Tyr Asp  Phe Ala Pro 
    1190                 1195                 1200             


Val Gly  Ala Thr Phe Val Arg  Val Thr Val Thr Asn  Ala Asp Thr 
    1205                 1210                 1215             


Thr Thr  Pro Ser Gly Val Val  Cys Ala Gly Leu Thr  Glu Ile Glu 
    1220                 1225                 1230             


Leu Lys  Thr Ala Thr Ser Lys  Phe Val Ala Asn Thr  Ser Ala Ala 
    1235                 1240                 1245             


Leu Ser  Ser Leu Thr Val Asn  Gly Thr Lys Val Ser  Asp Ser Val 
    1250                 1255                 1260             


Leu Ala  Ala Gly Ser Tyr Asn  Thr Pro Ala Ile Ile  Ala Asp Val 
    1265                 1270                 1275             


Lys Ala  Glu Gly Glu Gly Asn  Ala Ser Val Thr Val  Leu Pro Ala 
    1280                 1285                 1290             


His Asp  Asn Val Ile Arg Val  Ile Thr Glu Ser Glu  Asp His Val 
    1295                 1300                 1305             


Thr Arg  Lys Thr Phe Thr Ile  Asn Leu Gly Thr Glu  Gln Glu Phe 
    1310                 1315                 1320             


Pro Ala  Asp Ser Asp Glu Arg  Asp Gln His Gln His  Gln His Gln 
    1325                 1330                 1335             


His Gln  Gln 
    1340     


<210>  3
<211>  1752
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  3

Met Ala Val Arg Arg Leu Gly Gly Arg Ile Val Ala Phe Ala Ala Thr 
1               5                   10                  15      


Val Ala Leu Ser Ile Pro Leu Gly Leu Leu Thr Asn Ser Ala Trp Ala 
            20                  25                  30          


Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
        35                  40                  45              


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
    50                  55                  60                  


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
65                  70                  75                  80  


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
                85                  90                  95      


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
            100                 105                 110         


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
        115                 120                 125             


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
    130                 135                 140                 


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
145                 150                 155                 160 


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
                165                 170                 175     


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
            180                 185                 190         


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
        195                 200                 205             


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
    210                 215                 220                 


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asp Val Thr Met 
225                 230                 235                 240 


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Glu Ala Ala Ala Asn Ile 
                245                 250                 255     


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
            260                 265                 270         


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
        275                 280                 285             


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
    290                 295                 300                 


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
305                 310                 315                 320 


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
                325                 330                 335     


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
        355                 360                 365             


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
    370                 375                 380                 


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
385                 390                 395                 400 


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
                405                 410                 415     


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
            420                 425                 430         


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
        435                 440                 445             


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
    450                 455                 460                 


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
465                 470                 475                 480 


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
                485                 490                 495     


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
            500                 505                 510         


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
        515                 520                 525             


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
    530                 535                 540                 


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
545                 550                 555                 560 


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
                565                 570                 575     


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
            580                 585                 590         


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
        595                 600                 605             


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
    610                 615                 620                 


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
625                 630                 635                 640 


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
                645                 650                 655     


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
            660                 665                 670         


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
        675                 680                 685             


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
    690                 695                 700                 


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
705                 710                 715                 720 


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
                725                 730                 735     


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ser Asp Lys Asp Ser 
            740                 745                 750         


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
        755                 760                 765             


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
    770                 775                 780                 


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
785                 790                 795                 800 


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
                805                 810                 815     


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
            820                 825                 830         


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
        835                 840                 845             


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
    850                 855                 860                 


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
865                 870                 875                 880 


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
                885                 890                 895     


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
            900                 905                 910         


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
        915                 920                 925             


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
    930                 935                 940                 


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
945                 950                 955                 960 


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
                965                 970                 975     


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
            980                 985                 990         


Glu Ile Gly Ala Leu Leu Asn Tyr  Ser Ala Ser Thr Pro  Val Gly Thr 
        995                 1000                 1005             


Pro Ala  Val Leu Pro Gly Ser  Arg Pro Ala Val Leu  Pro Asp Gly 
    1010                 1015                 1020             


Thr Val  Thr Ser Ala Asn Phe  Ala Val His Trp Thr  Lys Pro Ala 
    1025                 1030                 1035             


Asp Thr  Val Tyr Asn Thr Ala  Gly Thr Val Lys Val  Pro Gly Thr 
    1040                 1045                 1050             


Ala Thr  Val Phe Gly Lys Glu  Phe Lys Val Thr Ala  Thr Ile Arg 
    1055                 1060                 1065             


Val Gln  Arg Ser Gln Val Thr  Ile Gly Ser Ser Val  Ser Gly Asn 
    1070                 1075                 1080             


Ala Leu  Arg Leu Thr Gln Asn  Ile Pro Ala Asp Lys  Gln Ser Asp 
    1085                 1090                 1095             


Thr Leu  Asp Ala Ile Lys Asp  Gly Ser Thr Thr Val  Asp Ala Asn 
    1100                 1105                 1110             


Thr Gly  Gly Gly Ala Asn Pro  Ser Ala Trp Thr Asn  Trp Ala Tyr 
    1115                 1120                 1125             


Ser Lys  Ala Gly His Asn Thr  Ala Glu Ile Thr Phe  Glu Tyr Ala 
    1130                 1135                 1140             


Thr Glu  Gln Gln Leu Gly Gln  Ile Val Met Tyr Phe  Phe Arg Asp 
    1145                 1150                 1155             


Ser Asn  Ala Val Arg Phe Pro  Asp Ala Gly Lys Thr  Lys Ile Gln 
    1160                 1165                 1170             


Ile Ser  Ala Asp Gly Lys Asn  Trp Thr Asp Leu Ala  Ala Thr Glu 
    1175                 1180                 1185             


Thr Ile  Ala Ala Gln Glu Ser  Ser Asp Arg Val Lys  Pro Tyr Thr 
    1190                 1195                 1200             


Tyr Asp  Phe Ala Pro Val Gly  Ala Thr Phe Val Lys  Val Thr Val 
    1205                 1210                 1215             


Thr Asn  Ala Asp Thr Thr Thr  Pro Ser Gly Val Val  Cys Ala Gly 
    1220                 1225                 1230             


Leu Thr  Glu Ile Glu Leu Lys  Thr Ala Thr Ser Lys  Phe Val Thr 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Leu Ser  Ser Leu Thr Val Asn  Gly Thr Lys 
    1250                 1255                 1260             


Val Ser  Asp Ser Val Leu Ala  Ala Gly Ser Tyr Asn  Thr Pro Ala 
    1265                 1270                 1275             


Ile Ile  Ala Asp Val Lys Ala  Glu Gly Glu Gly Asn  Ala Ser Val 
    1280                 1285                 1290             


Thr Val  Leu Pro Ala His Asp  Asn Val Ile Arg Val  Ile Thr Glu 
    1295                 1300                 1305             


Ser Glu  Asp His Val Thr Arg  Lys Thr Phe Thr Ile  Asn Leu Gly 
    1310                 1315                 1320             


Thr Glu  Gln Glu Phe Pro Ala  Asp Ser Asp Glu Arg  Asp Tyr Pro 
    1325                 1330                 1335             


Ala Ala  Asp Met Thr Val Thr  Val Gly Ser Glu Gln  Thr Ser Gly 
    1340                 1345                 1350             


Thr Ala  Thr Glu Gly Pro Lys  Lys Phe Ala Val Asp  Gly Asn Thr 
    1355                 1360                 1365             


Ser Thr  Tyr Trp His Ser Asn  Trp Thr Pro Thr Thr  Val Asn Asp 
    1370                 1375                 1380             


Leu Trp  Ile Ala Phe Glu Leu  Gln Lys Pro Thr Lys  Leu Asp Ala 
    1385                 1390                 1395             


Leu Arg  Tyr Leu Pro Arg Pro  Ala Gly Ser Lys Asn  Gly Ser Val 
    1400                 1405                 1410             


Thr Glu  Tyr Lys Val Gln Val  Ser Asp Asp Gly Thr  Asn Trp Thr 
    1415                 1420                 1425             


Asp Ala  Gly Ser Gly Thr Trp  Thr Thr Asp Tyr Gly  Trp Lys Leu 
    1430                 1435                 1440             


Ala Glu  Phe Asn Gln Pro Val  Thr Thr Lys His Val  Arg Leu Lys 
    1445                 1450                 1455             


Ala Val  His Thr Tyr Ala Asp  Ser Gly Asn Asp Lys  Phe Met Ser 
    1460                 1465                 1470             


Ala Ser  Glu Ile Arg Leu Arg  Lys Ala Val Asp Thr  Thr Asp Ile 
    1475                 1480                 1485             


Ser Gly  Ala Thr Val Thr Val  Pro Ala Lys Leu Thr  Val Asp Arg 
    1490                 1495                 1500             


Val Asp  Ala Asp His Pro Ala  Thr Phe Ala Thr Lys  Asp Val Thr 
    1505                 1510                 1515             


Val Thr  Leu Gly Asp Ala Thr  Leu Arg Tyr Gly Val  Asp Tyr Leu 
    1520                 1525                 1530             


Leu Asp  Tyr Ala Gly Asn Thr  Ala Val Gly Lys Ala  Thr Val Thr 
    1535                 1540                 1545             


Val Arg  Gly Ile Asp Lys Tyr  Ser Gly Thr Val Ala  Lys Thr Phe 
    1550                 1555                 1560             


Thr Ile  Glu Leu Lys Asn Ala  Pro Ala Pro Glu Pro  Thr Leu Thr 
    1565                 1570                 1575             


Ser Val  Ser Val Lys Thr Lys  Pro Ser Lys Leu Thr  Tyr Val Val 
    1580                 1585                 1590             


Gly Asp  Ala Phe Asp Pro Ala  Gly Leu Val Leu Gln  His Asp Arg 
    1595                 1600                 1605             


Gln Ala  Asp Arg Pro Pro Gln  Pro Leu Val Gly Glu  Gln Ala Asp 
    1610                 1615                 1620             


Glu Arg  Gly Leu Thr Cys Gly  Thr Arg Cys Asp Arg  Val Glu Gln 
    1625                 1630                 1635             


Leu Arg  Lys His Glu Asn Arg  Glu Ala His Arg Thr  Gly Leu Asp 
    1640                 1645                 1650             


His Leu  Glu Phe Val Gly Ala  Ala Asp Gly Ala Val  Gly Glu Gln 
    1655                 1660                 1665             


Ala Thr  Phe Lys Val His Val  His Ala Asp Gln Gly  Asp Gly Arg 
    1670                 1675                 1680             


His Asp  Asp Ala Asp Glu Arg  Asp Ile Asp Pro His  Val Pro Val 
    1685                 1690                 1695             


Asp His  Ala Val Gly Glu Leu  Ala Arg Ala Ala Cys  His His Val 
    1700                 1705                 1710             


Ile Gly  Leu Arg Val Asp Thr  His Arg Leu Lys Ala  Ser Gly Phe 
    1715                 1720                 1725             


Gln Ile  Pro Ala Asp Asp Met  Ala Glu Ile Asp Arg  Ile Thr Gly 
    1730                 1735                 1740             


Phe His  Arg Phe Glu Arg His  Val Gly 
    1745                 1750         


<210>  4
<211>  1935
<212>  PRT
<213>  Bifidobacterium bifidum

<400>  4

Met Ala Val Arg Arg Leu Gly Gly Arg Ile Val Ala Phe Ala Ala Thr 
1               5                   10                  15      


Val Ala Leu Ser Ile Pro Leu Gly Leu Leu Thr Asn Ser Ala Trp Ala 
            20                  25                  30          


Val Glu Asp Ala Thr Arg Ser Asp Ser Thr Thr Gln Met Ser Ser Thr 
        35                  40                  45              


Pro Glu Val Val Tyr Ser Ser Ala Val Asp Ser Lys Gln Asn Arg Thr 
    50                  55                  60                  


Ser Asp Phe Asp Ala Asn Trp Lys Phe Met Leu Ser Asp Ser Val Gln 
65                  70                  75                  80  


Ala Gln Asp Pro Ala Phe Asp Asp Ser Ala Trp Gln Gln Val Asp Leu 
                85                  90                  95      


Pro His Asp Tyr Ser Ile Thr Gln Lys Tyr Ser Gln Ser Asn Glu Ala 
            100                 105                 110         


Glu Ser Ala Tyr Leu Pro Gly Gly Thr Gly Trp Tyr Arg Lys Ser Phe 
        115                 120                 125             


Thr Ile Asp Arg Asp Leu Ala Gly Lys Arg Ile Ala Ile Asn Phe Asp 
    130                 135                 140                 


Gly Val Tyr Met Asn Ala Thr Val Trp Phe Asn Gly Val Lys Leu Gly 
145                 150                 155                 160 


Thr His Pro Tyr Gly Tyr Ser Pro Phe Ser Phe Asp Leu Thr Gly Asn 
                165                 170                 175     


Ala Lys Phe Gly Gly Glu Asn Thr Ile Val Val Lys Val Glu Asn Arg 
            180                 185                 190         


Leu Pro Ser Ser Arg Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val 
        195                 200                 205             


Thr Leu Thr Val Thr Asp Gly Val His Val Gly Asn Asn Gly Val Ala 
    210                 215                 220                 


Ile Lys Thr Pro Ser Leu Ala Thr Gln Asn Gly Gly Asn Val Thr Met 
225                 230                 235                 240 


Asn Leu Thr Thr Lys Val Ala Asn Asp Thr Lys Ala Ala Ala Asn Ile 
                245                 250                 255     


Thr Leu Lys Gln Thr Val Phe Pro Lys Gly Gly Lys Thr Asp Ala Ala 
            260                 265                 270         


Ile Gly Thr Val Thr Thr Ala Ser Lys Ser Ile Ala Ala Gly Ala Ser 
        275                 280                 285             


Ala Asp Val Thr Ser Thr Ile Thr Ala Ala Ser Pro Lys Leu Trp Ser 
    290                 295                 300                 


Ile Lys Asn Pro Asn Leu Tyr Thr Val Arg Thr Glu Val Leu Asn Gly 
305                 310                 315                 320 


Gly Lys Val Leu Asp Thr Tyr Asp Thr Glu Tyr Gly Phe Arg Trp Thr 
                325                 330                 335     


Gly Phe Asp Ala Thr Ser Gly Phe Ser Leu Asn Gly Glu Lys Val Lys 
            340                 345                 350         


Leu Lys Gly Val Ser Met His His Asp Gln Gly Ser Leu Gly Ala Val 
        355                 360                 365             


Ala Asn Arg Arg Ala Ile Glu Arg Gln Val Glu Ile Leu Gln Lys Met 
    370                 375                 380                 


Gly Val Asn Ser Ile Arg Thr Thr His Asn Pro Ala Ala Lys Ala Leu 
385                 390                 395                 400 


Ile Asp Val Cys Asn Glu Lys Gly Val Leu Val Val Glu Glu Val Phe 
                405                 410                 415     


Asp Met Trp Asn Arg Ser Lys Asn Gly Asn Thr Glu Asp Tyr Gly Lys 
            420                 425                 430         


Trp Phe Gly Gln Ala Ile Ala Gly Asp Asn Ala Val Leu Gly Gly Asp 
        435                 440                 445             


Lys Asp Glu Thr Trp Ala Lys Phe Asp Leu Thr Ser Thr Ile Asn Arg 
    450                 455                 460                 


Asp Arg Asn Ala Pro Ser Val Ile Met Trp Ser Leu Gly Asn Glu Met 
465                 470                 475                 480 


Met Glu Gly Ile Ser Gly Ser Val Ser Gly Phe Pro Ala Thr Ser Ala 
                485                 490                 495     


Lys Leu Val Ala Trp Thr Lys Ala Ala Asp Ser Thr Arg Pro Met Thr 
            500                 505                 510         


Tyr Gly Asp Asn Lys Ile Lys Ala Asn Trp Asn Glu Ser Asn Thr Met 
        515                 520                 525             


Gly Asp Asn Leu Thr Ala Asn Gly Gly Val Val Gly Thr Asn Tyr Ser 
    530                 535                 540                 


Asp Gly Ala Asn Tyr Asp Lys Ile Arg Thr Thr His Pro Ser Trp Ala 
545                 550                 555                 560 


Ile Tyr Gly Ser Glu Thr Ala Ser Ala Ile Asn Ser Arg Gly Ile Tyr 
                565                 570                 575     


Asn Arg Thr Thr Gly Gly Ala Gln Ser Ser Asp Lys Gln Leu Thr Ser 
            580                 585                 590         


Tyr Asp Asn Ser Ala Val Gly Trp Gly Ala Val Ala Ser Ser Ala Trp 
        595                 600                 605             


Tyr Asp Val Val Gln Arg Asp Phe Val Ala Gly Thr Tyr Val Trp Thr 
    610                 615                 620                 


Gly Phe Asp Tyr Leu Gly Glu Pro Thr Pro Trp Asn Gly Thr Gly Ser 
625                 630                 635                 640 


Gly Ala Val Gly Ser Trp Pro Ser Pro Lys Asn Ser Tyr Phe Gly Ile 
                645                 650                 655     


Val Asp Thr Ala Gly Phe Pro Lys Asp Thr Tyr Tyr Phe Tyr Gln Ser 
            660                 665                 670         


Gln Trp Asn Asp Asp Val His Thr Leu His Ile Leu Pro Ala Trp Asn 
        675                 680                 685             


Glu Asn Val Val Ala Lys Gly Ser Gly Asn Asn Val Pro Val Val Val 
    690                 695                 700                 


Tyr Thr Asp Ala Ala Lys Val Lys Leu Tyr Phe Thr Pro Lys Gly Ser 
705                 710                 715                 720 


Thr Glu Lys Arg Leu Ile Gly Glu Lys Ser Phe Thr Lys Lys Thr Thr 
                725                 730                 735     


Ala Ala Gly Tyr Thr Tyr Gln Val Tyr Glu Gly Ala Asp Lys Asp Ser 
            740                 745                 750         


Thr Ala His Lys Asn Met Tyr Leu Thr Trp Asn Val Pro Trp Ala Glu 
        755                 760                 765             


Gly Thr Ile Ser Ala Glu Ala Tyr Asp Glu Asn Asn Arg Leu Ile Pro 
    770                 775                 780                 


Glu Gly Ser Thr Glu Gly Asn Ala Ser Val Thr Thr Thr Gly Lys Ala 
785                 790                 795                 800 


Ala Lys Leu Lys Ala Asp Ala Asp Arg Lys Thr Ile Thr Ala Asp Gly 
                805                 810                 815     


Lys Asp Leu Ser Tyr Ile Glu Val Asp Val Thr Asp Ala Asn Gly His 
            820                 825                 830         


Ile Val Pro Asp Ala Ala Asn Arg Val Thr Phe Asp Val Lys Gly Ala 
        835                 840                 845             


Gly Lys Leu Val Gly Val Asp Asn Gly Ser Ser Pro Asp His Asp Ser 
    850                 855                 860                 


Tyr Gln Ala Asp Asn Arg Lys Ala Phe Ser Gly Lys Val Leu Ala Ile 
865                 870                 875                 880 


Val Gln Ser Thr Lys Glu Ala Gly Glu Ile Thr Val Thr Ala Lys Ala 
                885                 890                 895     


Asp Gly Leu Gln Ser Ser Thr Val Lys Ile Ala Thr Thr Ala Val Pro 
            900                 905                 910         


Gly Thr Ser Thr Glu Lys Thr Val Arg Ser Phe Tyr Tyr Ser Arg Asn 
        915                 920                 925             


Tyr Tyr Val Lys Thr Gly Asn Lys Pro Ile Leu Pro Ser Asp Val Glu 
    930                 935                 940                 


Val Arg Tyr Ser Asp Gly Thr Ser Asp Arg Gln Asn Val Thr Trp Asp 
945                 950                 955                 960 


Ala Val Ser Asp Asp Gln Ile Ala Lys Ala Gly Ser Phe Ser Val Ala 
                965                 970                 975     


Gly Thr Val Ala Gly Gln Lys Ile Ser Val Arg Val Thr Met Ile Asp 
            980                 985                 990         


Glu Ile Gly Ala Leu Leu Asn Tyr  Ser Ala Ser Thr Pro  Val Gly Thr 
        995                 1000                 1005             


Pro Ala  Val Leu Pro Gly Ser  Arg Pro Ala Val Leu  Pro Asp Gly 
    1010                 1015                 1020             


Thr Val  Thr Ser Ala Asn Phe  Ala Val Asp Trp Thr  Lys Pro Ala 
    1025                 1030                 1035             


Asp Thr  Val Tyr Asn Thr Ala  Gly Thr Val Lys Val  Pro Gly Thr 
    1040                 1045                 1050             


Ala Thr  Val Phe Gly Lys Glu  Phe Lys Val Thr Ala  Thr Ile Arg 
    1055                 1060                 1065             


Val Gln  Arg Ser Gln Val Thr  Ile Gly Ser Ser Val  Ser Gly Asn 
    1070                 1075                 1080             


Ala Leu  Arg Leu Thr Gln Asn  Ile Pro Ala Asp Lys  Gln Ser Asp 
    1085                 1090                 1095             


Thr Leu  Asp Ala Ile Lys Asp  Gly Ser Thr Thr Val  Asp Ala Asn 
    1100                 1105                 1110             


Thr Gly  Gly Gly Ala Asn Pro  Ser Ala Trp Thr Asn  Trp Ala Tyr 
    1115                 1120                 1125             


Ser Lys  Ala Gly His Asn Thr  Ala Glu Ile Thr Phe  Glu Tyr Ala 
    1130                 1135                 1140             


Thr Glu  Gln Gln Leu Gly Gln  Ile Val Met Tyr Phe  Phe Arg Asp 
    1145                 1150                 1155             


Ser Asn  Ala Val Arg Phe Pro  Asp Ala Gly Lys Thr  Lys Ile Gln 
    1160                 1165                 1170             


Ile Ser  Ala Asp Gly Lys Asn  Trp Thr Asp Leu Ala  Ala Thr Glu 
    1175                 1180                 1185             


Thr Ile  Ala Ala Gln Glu Ser  Ser Asp Arg Val Lys  Pro Tyr Thr 
    1190                 1195                 1200             


Tyr Asp  Phe Ala Pro Val Gly  Ala Thr Phe Val Lys  Val Thr Val 
    1205                 1210                 1215             


Thr Asn  Ala Asp Thr Thr Thr  Pro Ser Gly Val Val  Cys Ala Gly 
    1220                 1225                 1230             


Leu Thr  Glu Ile Glu Leu Lys  Thr Ala Thr Ser Lys  Phe Val Thr 
    1235                 1240                 1245             


Asn Thr  Ser Ala Ala Leu Ser  Ser Leu Thr Val Asn  Gly Thr Lys 
    1250                 1255                 1260             


Val Ser  Asp Ser Val Leu Ala  Ala Gly Ser Tyr Asn  Thr Pro Ala 
    1265                 1270                 1275             


Ile Ile  Ala Asp Val Lys Ala  Glu Gly Glu Gly Asn  Ala Ser Val 
    1280                 1285                 1290             


Thr Val  Leu Pro Ala His Asp  Asn Val Ile Arg Val  Ile Thr Glu 
    1295                 1300                 1305             


Ser Glu  Asp His Val Thr Arg  Lys Thr Phe Thr Ile  Asn Leu Gly 
    1310                 1315                 1320             


Thr Glu  Gln Glu Phe Pro Ala  Asp Ser Asp Glu Arg  Asp Tyr Pro 
    1325                 1330                 1335             


Ala Ala  Asp Met Thr Val Thr  Ala Gly Ser Glu Gln  Thr Ser Gly 
    1340                 1345                 1350             


Thr Ala  Thr Glu Gly Pro Lys  Lys Phe Ala Val Asp  Gly Asn Thr 
    1355                 1360                 1365             


Ser Thr  Tyr Trp His Ser Asn  Trp Thr Pro Thr Thr  Val Asn Asp 
    1370                 1375                 1380             


Leu Trp  Ile Ala Phe Glu Leu  Gln Lys Pro Thr Lys  Leu Asp Ala 
    1385                 1390                 1395             


Leu Arg  Tyr Leu Pro Arg Pro  Ala Gly Ser Lys Asn  Gly Ser Val 
    1400                 1405                 1410             


Thr Glu  Tyr Lys Val Gln Val  Ser Asp Asp Gly Thr  Asn Trp Thr 
    1415                 1420                 1425             


Asp Ala  Gly Ser Gly Thr Trp  Thr Thr Asp Tyr Gly  Trp Lys Leu 
    1430                 1435                 1440             


Ala Glu  Phe Asn Gln Pro Val  Thr Thr Lys His Val  Arg Leu Lys 
    1445                 1450                 1455             


Ala Val  His Thr Tyr Ala Asp  Ser Gly Asn Asp Lys  Phe Met Ser 
    1460                 1465                 1470             


Ala Ser  Glu Ile Arg Leu Arg  Lys Ala Val Asp Thr  Thr Asp Ile 
    1475                 1480                 1485             


Ser Gly  Ala Thr Val Thr Val  Pro Ala Lys Leu Thr  Val Asp Arg 
    1490                 1495                 1500             


Val Asp  Ala Asp His Pro Ala  Thr Phe Ala Thr Lys  Asp Val Thr 
    1505                 1510                 1515             


Val Thr  Leu Gly Asp Ala Thr  Leu Arg Tyr Gly Val  Asp Tyr Leu 
    1520                 1525                 1530             


Leu Asp  Tyr Ala Gly Asn Thr  Ala Val Gly Lys Ala  Thr Val Thr 
    1535                 1540                 1545             


Val Arg  Gly Ile Asp Lys Tyr  Ser Gly Thr Val Ala  Lys Thr Phe 
    1550                 1555                 1560             


Thr Ile  Glu Leu Lys Asn Ala  Pro Ala Pro Glu Pro  Thr Leu Thr 
    1565                 1570                 1575             


Ser Val  Ser Val Lys Thr Lys  Pro Ser Lys Leu Thr  Tyr Val Val 
    1580                 1585                 1590             


Gly Asp  Ala Phe Asp Pro Ala  Gly Leu Val Leu Gln  Leu Asn Tyr 
    1595                 1600                 1605             


Asp Asp  Asp Ser Thr Gly Thr  Val Thr Trp Asn Thr  Gln Thr Ala 
    1610                 1615                 1620             


Gly Asp  Phe Thr Phe Lys Pro  Ala Leu Asp Ala Lys  Leu Lys Val 
    1625                 1630                 1635             


Thr Asp  Lys Thr Val Thr Val  Thr Tyr Gln Gly Lys  Ser Ala Val 
    1640                 1645                 1650             


Ile Asp  Ile Thr Val Ser Gln  Pro Ala Pro Thr Val  Ser Lys Thr 
    1655                 1660                 1665             


Asp Leu  Asp Lys Ala Ile Lys  Ala Ile Glu Ala Lys  Asn Pro Asp 
    1670                 1675                 1680             


Ser Ser  Lys Tyr Thr Ala Asp  Ser Trp Lys Thr Phe  Ala Asp Ala 
    1685                 1690                 1695             


Met Ala  His Ala Lys Ala Val  Ile Ala Asp Asp Ser  Ala Thr Gln 
    1700                 1705                 1710             


Gln Asp  Val Asp Lys Ala Leu  Lys Ala Leu Thr Asp  Ala Tyr Ala 
    1715                 1720                 1725             


Gly Leu  Thr Glu Lys Thr Pro  Glu Pro Ala Pro Val  Ser Lys Ser 
    1730                 1735                 1740             


Glu Leu  Asp Lys Lys Ile Lys  Ala Ile Glu Ala Glu  Lys Leu Asp 
    1745                 1750                 1755             


Gly Ser  Lys Tyr Thr Ala Glu  Ser Trp Lys Ala Phe  Glu Thr Ala 
    1760                 1765                 1770             


Leu Ala  His Ala Lys Ala Val  Ile Ala Ser Asp Ser  Ala Thr Gln 
    1775                 1780                 1785             


Gln Asp  Val Asp Ala Ala Leu  Gly Ala Leu Thr Ser  Ala Arg Asp 
    1790                 1795                 1800             


Gly Leu  Thr Glu Lys Gly Glu  Val Lys Pro Asp Pro  Lys Pro Glu 
    1805                 1810                 1815             


Pro Gly  Thr Val Asp Lys Ala  Ala Leu Asp Lys Ala  Val Lys Lys 
    1820                 1825                 1830             


Val Glu  Ala Glu Lys Leu Asp  Gly Ser Lys Tyr Thr  Ala Asp Ser 
    1835                 1840                 1845             


Trp Lys  Ala Phe Glu Thr Ala  Leu Ala His Ala Lys  Ala Val Ile 
    1850                 1855                 1860             


Gly Asn  Ala Asn Ser Thr Gln  Phe Asp Ile Asp Asn  Ala Leu Ser 
    1865                 1870                 1875             


Met Leu  Asn Asp Ala Arg Ala  Ala Leu Lys Glu Lys  Pro Gly Arg 
    1880                 1885                 1890             


Ile Ile  Ala Ile Ile Asp Gly  Gly Ala Leu Ser Lys  Thr Gly Ala 
    1895                 1900                 1905             


Ser Val  Ala Ile Ile Ala Ser  Val Ala Ala Ala Met  Lys Ala Val 
    1910                 1915                 1920             


Gly Ala  Gly Val Met Ala Leu  Arg Pro Pro Lys Trp  
    1925                 1930                 1935 



