﻿                         序列表

<110>  中国农业科学院饲料研究所

<120>  胃蛋白抗性和耐酸性改良及催化效率提高的植酸酶YeAPPA突变体

<150>  201710027074.8
<151>  2017-01-15

<160>  12

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  441
<212>  PRT
<213>  Yersinia enterocolitica）

<400>  1
Met Ser Val Ala Lys Arg Asn Leu His Leu Ser Ala Leu Thr Leu Ile 
1               5                   10                  15      
Met Gly Cys Phe Thr Ala Gly Ala Ala Pro Ile Ala Thr Pro Pro Ala 
            20                  25                  30          
Ser Tyr Thr Leu Glu Arg Val Val Ile Leu Ser Arg His Gly Val Arg 
        35                  40                  45              
Ser Pro Thr Lys Gln Thr Gln Leu Met Asn Asp Val Thr Pro Asp Lys 
    50                  55                  60                  
Trp Pro Leu Trp Pro Val Lys Ala Gly Tyr Leu Thr Pro Arg Arg Ala 
65                  70                  75                  80  
Glu Leu Val Thr Leu Met Gly Gly Phe Tyr Gly Asp Tyr Phe Arg Ser 
                85                  90                  95      
Gln Gly Leu Leu Ser Ala Gly Cys Pro Val Asp Gly Ser Val Tyr Ala 
            100                 105                 110         
Gln Ala Asp Val Asp Gln Arg Thr Arg Leu Thr Gly Gln Ala Phe Leu 
        115                 120                 125             
Asp Gly Ile Ala Pro Asp Cys Gly Leu Lys Val His Tyr Gln Ala Asp 
    130                 135                 140                 
Leu Lys Lys Val Asp Pro Leu Phe His Thr Val Glu Ala Gly Val Cys 
145                 150                 155                 160 
Lys Leu Asp Ser Ala Lys Thr His Gln Ala Val Glu Glu Arg Leu Gly 
                165                 170                 175     
Gly Pro Leu Ser Asp Leu Ser Gln Arg Tyr Ala Lys Pro Phe Ala Gln 
            180                 185                 190         
Met Gly Glu Val Leu Asn Phe Ala Ala Ser Pro Tyr Cys Lys Ser Leu 
        195                 200                 205             
Gln Lys Asn Gly Lys Thr Cys Asp Phe Ala Thr Phe Thr Ala Asn Glu 
    210                 215                 220                 
Ile Lys Val Asn Glu Glu Gly Thr Lys Val Ser Leu Ser Gly Pro Leu 
225                 230                 235                 240 
Ala Leu Ser Ser Thr Leu Gly Glu Ile Phe Leu Leu Gln Asp Ser Gln 
                245                 250                 255     
Ala Met Pro Asp Val Ala Trp His Arg Leu Ser Gly Glu Glu Asn Trp 
            260                 265                 270         
Val Ser Leu Leu Ser Leu Arg Asn Ala Gln Phe Asp Leu Met Ala Lys 
        275                 280                 285             
Thr Pro Tyr Ile Ala Arg His Lys Gly Thr Pro Leu Leu Gln Gln Ile 
    290                 295                 300                 
Asp Thr Ala Leu Val Leu Gln Arg Asp Ala Gln Gly Gln Thr Leu Pro 
305                 310                 315                 320 
Leu Ser Pro Gln Thr Lys Leu Leu Phe Leu Gly Gly His Asp Thr Asn 
                325                 330                 335     
Ile Ala Asn Ile Ala Gly Met Leu Gly Ala Asn Trp Gln Leu Pro Gln 
            340                 345                 350         
Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu Val Phe Glu Leu Trp 
        355                 360                 365             
Gln Asn Pro Asp Asn His Gln Arg Tyr Val Ala Val Lys Met Phe Tyr 
    370                 375                 380                 
Gln Thr Met Asp Gln Leu Arg Asn Ala Glu Lys Leu Asp Met Lys Asn 
385                 390                 395                 400 
Asn Pro Ala Lys Ile Val Pro Ile Thr Ile Glu Gly Cys Glu Asn Glu 
                405                 410                 415     
Gly Asp Asn Lys Leu Cys Gln Leu Glu Thr Phe Gln Lys Lys Val Ala 
            420                 425                 430         
Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440     

<210>  2
<211>  1326
<212>  DNA
<213>  Yersinia enterocolitica）

<400>  2
atgtcagttg caaagagaaa tctgcactta tccgcactca ctttgataat gggctgtttt        60
accgcaggtg ctgccccgat tgctacaccg ccggccagct acacattaga gcgtgtggtt       120
attttgagtc gacatggtgt tcgctccccg acaaaacaaa cccagctaat gaatgatgtc       180
acacctgata aatggcccct gtggccagta aaagcgggct atttaacacc gcgaagggct       240
gagttagtga ctttgatggg gggattttat ggtgattatt tccgcagcca agggttgttg       300
tctgcggggt gtccggtaga tggctccgtt tatgcacagg cagatgttga ccaacgaacc       360
cgcttaaccg gacaggcatt cttggatggg atcgcaccgg attgtggtct gaaagtacat       420
tatcaggctg atttgaagaa agttgacccg ctatttcata ccgtcgaagc gggggtctgt       480
aaactggact cagcgaaaac tcatcaggct gttgaggagc gattgggcgg gccattgagt       540
gatcttagcc agcgctatgc caaacccttt gctcagatgg gcgaagtgct gaattttgca       600
gcatcgcctt attgcaagtc attgcaaaaa aatggaaaaa cctgtgattt tgcaactttt       660
acggcaaatg aaattaaggt aaacgaagaa ggtactaaag tttctctgag tgggccattg       720
gcactatcgt cgacattggg tgaaattttc ctgttacaag actcacaagc tatgccggat       780
gtggcctggc atcggctcag cggtgaagag aactgggttt cgctattgtc gttgcgcaat       840
gcgcaatttg atttgatggc caaaaccccg tatatcgctc gccataaagg gaccccgctg       900
ttgcaacaaa ttgatacggc attagtgctg caacgcgatg cccaagggca aacactgccg       960
ctgtcaccgc aaaccaaatt gctgttcctc ggcgggcatg acaccaatat tgctaatatc      1020
gctggtatgt taggggccaa ttggcaatta ccacagcaac ctgataatac cccgcctggt      1080
ggcggattag tctttgagct atggcagaac ccagataatc atcagcgcta tgtcgccgtg      1140
aaaatgttct atcaaacgat ggatcagctg cgaaatgccg agaaattaga tatgaaaaac      1200
aacccagcta aaattgttcc aattaccatt gaaggttgtg agaacgaggg tgataacaaa      1260
ctttgccaac ttgagacttt ccaaaagaaa gttgcccaag tgatcgagcc agcctgccat      1320
atttaa                                                                 1326

<210>  3
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Met Ser Val Ala Lys Arg Asn Leu His Leu Ser Ala Leu Thr Leu Ile 
1               5                   10                  15      
Met Gly Cys Phe Thr Ala Gly Ala Ala Pro Ile Ala Thr Pro Pro Ala 
            20                  25                  30          
Ser Tyr Thr Leu Glu Arg Val Val Ile Leu Ser Arg His Gly Val Arg 
        35                  40                  45              
Ser Pro Thr Lys Gln Thr Gln Leu Met Asn Asp Val Thr Pro Asp Lys 
    50                  55                  60                  
Trp Pro Leu Trp Pro Val Lys Ala Gly Tyr Leu Thr Pro Arg Arg Ala 
65                  70                  75                  80  
Glu Leu Val Thr Leu Met Gly Gly Phe Tyr Gly Asp Tyr Phe Arg Ser 
                85                  90                  95      
Gln Gly Leu Leu Ser Ala Gly Cys Pro Val Asp Gly Ser Val Tyr Ala 
            100                 105                 110         
Gln Ala Asp Val Asp Gln Arg Thr Arg Leu Thr Gly Gln Ala Phe Leu 
        115                 120                 125             
Asp Gly Ile Ala Pro Asp Cys Gly Leu Lys Val His Tyr Gln Ala Asp 
    130                 135                 140                 
Leu Lys Lys Val Asp Pro Leu Phe His Thr Val Glu Ala Gly Val Cys 
145                 150                 155                 160 
Lys Gly Asp Ser Ala Lys Thr His Gln Ala Val Glu Glu Arg Leu Gly 
                165                 170                 175     
Gly Pro Leu Ser Asp Leu Ser Gln Arg Tyr Ala Lys Pro Phe Ala Gln 
            180                 185                 190         
Met Gly Glu Val Leu Asn Phe Ala Ala Ser Pro Tyr Cys Lys Ser Leu 
        195                 200                 205             
Gln Lys Asn Gly Lys Thr Cys Asp Phe Ala Thr Phe Thr Ala Asn Glu 
    210                 215                 220                 
Ile Lys Val Asn Glu Glu Gly Thr Lys Val Ser Leu Ser Gly Pro Leu 
225                 230                 235                 240 
Ala Leu Ser Ser Thr Leu Gly Glu Ile Phe Leu Leu Gln Asp Ser Gln 
                245                 250                 255     
Ala Met Pro Asp Val Ala Trp His Arg Leu Ser Gly Glu Glu Asn Trp 
            260                 265                 270         
Val Ser Leu Leu Ser Leu Arg Asn Ala Gln Phe Asp Leu Met Ala Lys 
        275                 280                 285             
Thr Pro Tyr Ile Ala Arg His Lys Gly Thr Pro Leu Leu Gln Gln Ile 
    290                 295                 300                 
Asp Thr Ala Leu Val Leu Gln Arg Asp Ala Gln Gly Gln Thr Leu Pro 
305                 310                 315                 320 
Leu Ser Pro Gln Thr Lys Leu Leu Phe Leu Gly Gly His Asp Thr Asn 
                325                 330                 335     
Ile Ala Asn Ile Ala Gly Met Leu Gly Ala Asn Trp Gln Leu Pro Gln 
            340                 345                 350         
Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu Val Phe Glu Leu Trp 
        355                 360                 365             
Gln Asn Pro Asp Asn His Gln Arg Tyr Val Ala Val Lys Met Phe Tyr 
    370                 375                 380                 
Gln Thr Met Asp Gln Leu Arg Asn Ala Glu Lys Leu Asp Met Lys Asn 
385                 390                 395                 400 
Asn Pro Ala Lys Ile Val Pro Ile Thr Ile Glu Gly Cys Glu Asn Glu 
                405                 410                 415     
Gly Asp Asn Lys Leu Cys Gln Leu Glu Thr Phe Gln Lys Lys Val Ala 
            420                 425                 430         
Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440     

<210>  4
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  4
Met Ser Val Ala Lys Arg Asn Leu His Leu Ser Ala Leu Thr Leu Ile 
1               5                   10                  15      
Met Gly Cys Phe Thr Ala Gly Ala Ala Pro Ile Ala Thr Pro Pro Ala 
            20                  25                  30          
Ser Tyr Thr Leu Glu Arg Val Val Ile Leu Ser Arg His Gly Val Arg 
        35                  40                  45              
Ser Pro Thr Lys Gln Thr Gln Leu Met Asn Asp Val Thr Pro Asp Lys 
    50                  55                  60                  
Trp Pro Leu Trp Pro Val Lys Ala Gly Tyr Leu Thr Pro Arg Arg Ala 
65                  70                  75                  80  
Glu Leu Val Thr Leu Met Gly Gly Phe Tyr Gly Asp Tyr Phe Arg Ser 
                85                  90                  95      
Gln Gly Leu Leu Ser Ala Gly Cys Pro Val Asp Gly Ser Val Tyr Ala 
            100                 105                 110         
Gln Ala Asp Val Asp Gln Arg Thr Arg Leu Thr Gly Gln Ala Phe Leu 
        115                 120                 125             
Asp Gly Ile Ala Pro Asp Cys Gly Leu Lys Val His Tyr Gln Ala Asp 
    130                 135                 140                 
Leu Lys Lys Val Asp Pro Leu Phe His Thr Val Glu Ala Gly Val Cys 
145                 150                 155                 160 
Lys Ala Asp Ser Ala Lys Thr His Gln Ala Val Glu Glu Arg Leu Gly 
                165                 170                 175     
Gly Pro Leu Ser Asp Leu Ser Gln Arg Tyr Ala Lys Pro Phe Ala Gln 
            180                 185                 190         
Met Gly Glu Val Leu Asn Phe Ala Ala Ser Pro Tyr Cys Lys Ser Leu 
        195                 200                 205             
Gln Lys Asn Gly Lys Thr Cys Asp Phe Ala Thr Phe Thr Ala Asn Glu 
    210                 215                 220                 
Ile Lys Val Asn Glu Glu Gly Thr Lys Val Ser Leu Ser Gly Pro Leu 
225                 230                 235                 240 
Ala Leu Ser Ser Thr Leu Gly Glu Ile Phe Leu Leu Gln Asp Ser Gln 
                245                 250                 255     
Ala Met Pro Asp Val Ala Trp His Arg Leu Ser Gly Glu Glu Asn Trp 
            260                 265                 270         
Val Ser Leu Leu Ser Leu Arg Asn Ala Gln Phe Asp Leu Met Ala Lys 
        275                 280                 285             
Thr Pro Tyr Ile Ala Arg His Lys Gly Thr Pro Leu Leu Gln Gln Ile 
    290                 295                 300                 
Asp Thr Ala Leu Val Leu Gln Arg Asp Ala Gln Gly Gln Thr Leu Pro 
305                 310                 315                 320 
Leu Ser Pro Gln Thr Lys Leu Leu Phe Leu Gly Gly His Asp Thr Asn 
                325                 330                 335     
Ile Ala Asn Ile Ala Gly Met Leu Gly Ala Asn Trp Gln Leu Pro Gln 
            340                 345                 350         
Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu Val Phe Glu Leu Trp 
        355                 360                 365             
Gln Asn Pro Asp Asn His Gln Arg Tyr Val Ala Val Lys Met Phe Tyr 
    370                 375                 380                 
Gln Thr Met Asp Gln Leu Arg Asn Ala Glu Lys Leu Asp Met Lys Asn 
385                 390                 395                 400 
Asn Pro Ala Lys Ile Val Pro Ile Thr Ile Glu Gly Cys Glu Asn Glu 
                405                 410                 415     
Gly Asp Asn Lys Leu Cys Gln Leu Glu Thr Phe Gln Lys Lys Val Ala 
            420                 425                 430         
Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440     

<210>  5
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Met Ser Val Ala Lys Arg Asn Leu His Leu Ser Ala Leu Thr Leu Ile 
1               5                   10                  15      
Met Gly Cys Phe Thr Ala Gly Ala Ala Pro Ile Ala Thr Pro Pro Ala 
            20                  25                  30          
Ser Tyr Thr Leu Glu Arg Val Val Ile Leu Ser Arg His Gly Val Arg 
        35                  40                  45              
Ser Pro Thr Lys Gln Thr Gln Leu Met Asn Asp Val Thr Pro Asp Lys 
    50                  55                  60                  
Trp Pro Leu Trp Pro Val Lys Ala Gly Tyr Leu Thr Pro Arg Arg Ala 
65                  70                  75                  80  
Glu Leu Val Thr Leu Met Gly Gly Phe Tyr Gly Asp Tyr Phe Arg Ser 
                85                  90                  95      
Gln Gly Leu Leu Ser Ala Gly Cys Pro Val Asp Gly Ser Val Tyr Ala 
            100                 105                 110         
Gln Ala Asp Val Asp Gln Arg Thr Arg Leu Thr Gly Gln Ala Phe Leu 
        115                 120                 125             
Asp Gly Ile Ala Pro Asp Cys Gly Leu Lys Val His Tyr Gln Ala Asp 
    130                 135                 140                 
Leu Lys Lys Val Asp Pro Leu Phe His Thr Val Glu Ala Gly Val Cys 
145                 150                 155                 160 
Lys Leu Asp Ser Ala Lys Thr His Gln Ala Val Glu Glu Arg Leu Gly 
                165                 170                 175     
Gly Pro Leu Ser Asp Leu Ser Gln Arg Tyr Ala Lys Pro Phe Ala Gln 
            180                 185                 190         
Met Gly Glu Val Leu Asn Phe Ala Ala Ser Pro Tyr Cys Lys Ser Leu 
        195                 200                 205             
Gln Lys Asn Gly Lys Thr Cys Asp Phe Ala Thr Phe Thr Ala Asn Glu 
    210                 215                 220                 
Ile Lys Val Asn Glu Gly Gly Thr Lys Val Ser Leu Ser Gly Pro Leu 
225                 230                 235                 240 
Ala Leu Ser Ser Thr Leu Gly Glu Ile Phe Leu Leu Gln Asp Ser Gln 
                245                 250                 255     
Ala Met Pro Asp Val Ala Trp His Arg Leu Ser Gly Glu Glu Asn Trp 
            260                 265                 270         
Val Ser Leu Leu Ser Leu Arg Asn Ala Gln Phe Asp Leu Met Ala Lys 
        275                 280                 285             
Thr Pro Tyr Ile Ala Arg His Lys Gly Thr Pro Leu Leu Gln Gln Ile 
    290                 295                 300                 
Asp Thr Ala Leu Val Leu Gln Arg Asp Ala Gln Gly Gln Thr Leu Pro 
305                 310                 315                 320 
Leu Ser Pro Gln Thr Lys Leu Leu Phe Leu Gly Gly His Asp Thr Asn 
                325                 330                 335     
Ile Ala Asn Ile Ala Gly Met Leu Gly Ala Asn Trp Gln Leu Pro Gln 
            340                 345                 350         
Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu Val Phe Glu Leu Trp 
        355                 360                 365             
Gln Asn Pro Asp Asn His Gln Arg Tyr Val Ala Val Lys Met Phe Tyr 
    370                 375                 380                 
Gln Thr Met Asp Gln Leu Arg Asn Ala Glu Lys Leu Asp Met Lys Asn 
385                 390                 395                 400 
Asn Pro Ala Lys Ile Val Pro Ile Thr Ile Glu Gly Cys Glu Asn Glu 
                405                 410                 415     
Gly Asp Asn Lys Leu Cys Gln Leu Glu Thr Phe Gln Lys Lys Val Ala 
            420                 425                 430         
Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440     

<210>  6
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  6
Met Ser Val Ala Lys Arg Asn Leu His Leu Ser Ala Leu Thr Leu Ile 
1               5                   10                  15      
Met Gly Cys Phe Thr Ala Gly Ala Ala Pro Ile Ala Thr Pro Pro Ala 
            20                  25                  30          
Ser Tyr Thr Leu Glu Arg Val Val Ile Leu Ser Arg His Gly Val Arg 
        35                  40                  45              
Ser Pro Thr Lys Gln Thr Gln Leu Met Asn Asp Val Thr Pro Asp Lys 
    50                  55                  60                  
Trp Pro Leu Trp Pro Val Lys Ala Gly Tyr Leu Thr Pro Arg Arg Ala 
65                  70                  75                  80  
Glu Leu Val Thr Leu Met Gly Gly Phe Tyr Gly Asp Tyr Phe Arg Ser 
                85                  90                  95      
Gln Gly Leu Leu Ser Ala Gly Cys Pro Val Asp Gly Ser Val Tyr Ala 
            100                 105                 110         
Gln Ala Asp Val Asp Gln Arg Thr Arg Leu Thr Gly Gln Ala Phe Leu 
        115                 120                 125             
Asp Gly Ile Ala Pro Asp Cys Gly Leu Lys Val His Tyr Gln Ala Asp 
    130                 135                 140                 
Leu Lys Lys Val Asp Pro Leu Phe His Thr Val Glu Ala Gly Val Cys 
145                 150                 155                 160 
Lys Leu Asp Ser Ala Lys Thr His Gln Ala Val Glu Glu Arg Leu Gly 
                165                 170                 175     
Gly Pro Leu Ser Asp Leu Ser Gln Arg Tyr Ala Lys Pro Phe Ala Gln 
            180                 185                 190         
Met Gly Glu Val Leu Asn Phe Ala Ala Ser Pro Tyr Cys Lys Ser Leu 
        195                 200                 205             
Gln Lys Asn Gly Lys Thr Cys Asp Phe Ala Thr Phe Thr Ala Asn Glu 
    210                 215                 220                 
Ile Lys Val Asn Glu Pro Gly Thr Lys Val Ser Leu Ser Gly Pro Leu 
225                 230                 235                 240 
Ala Leu Ser Ser Thr Leu Gly Glu Ile Phe Leu Leu Gln Asp Ser Gln 
                245                 250                 255     
Ala Met Pro Asp Val Ala Trp His Arg Leu Ser Gly Glu Glu Asn Trp 
            260                 265                 270         
Val Ser Leu Leu Ser Leu Arg Asn Ala Gln Phe Asp Leu Met Ala Lys 
        275                 280                 285             
Thr Pro Tyr Ile Ala Arg His Lys Gly Thr Pro Leu Leu Gln Gln Ile 
    290                 295                 300                 
Asp Thr Ala Leu Val Leu Gln Arg Asp Ala Gln Gly Gln Thr Leu Pro 
305                 310                 315                 320 
Leu Ser Pro Gln Thr Lys Leu Leu Phe Leu Gly Gly His Asp Thr Asn 
                325                 330                 335     
Ile Ala Asn Ile Ala Gly Met Leu Gly Ala Asn Trp Gln Leu Pro Gln 
            340                 345                 350         
Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu Val Phe Glu Leu Trp 
        355                 360                 365             
Gln Asn Pro Asp Asn His Gln Arg Tyr Val Ala Val Lys Met Phe Tyr 
    370                 375                 380                 
Gln Thr Met Asp Gln Leu Arg Asn Ala Glu Lys Leu Asp Met Lys Asn 
385                 390                 395                 400 
Asn Pro Ala Lys Ile Val Pro Ile Thr Ile Glu Gly Cys Glu Asn Glu 
                405                 410                 415     
Gly Asp Asn Lys Leu Cys Gln Leu Glu Thr Phe Gln Lys Lys Val Ala 
            420                 425                 430         
Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440     

<210>  7
<211>  441
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Met Ser Val Ala Lys Arg Asn Leu His Leu Ser Ala Leu Thr Leu Ile 
1               5                   10                  15      
Met Gly Cys Phe Thr Ala Gly Ala Ala Pro Ile Ala Thr Pro Pro Ala 
            20                  25                  30          
Ser Tyr Thr Leu Glu Arg Val Val Ile Leu Ser Arg His Gly Val Arg 
        35                  40                  45              
Ser Pro Thr Lys Gln Thr Gln Leu Met Asn Asp Val Thr Pro Asp Lys 
    50                  55                  60                  
Trp Pro Leu Trp Pro Val Lys Ala Gly Tyr Leu Thr Pro Arg Arg Ala 
65                  70                  75                  80  
Glu Leu Val Thr Leu Met Gly Gly Phe Tyr Gly Asp Tyr Phe Arg Ser 
                85                  90                  95      
Gln Gly Leu Leu Ser Ala Gly Cys Pro Val Asp Gly Ser Val Tyr Ala 
            100                 105                 110         
Gln Ala Asp Val Asp Gln Arg Thr Arg Leu Thr Gly Gln Ala Phe Leu 
        115                 120                 125             
Asp Gly Ile Ala Pro Asp Cys Gly Leu Lys Val His Tyr Gln Ala Asp 
    130                 135                 140                 
Leu Lys Lys Val Asp Pro Leu Phe His Thr Val Glu Ala Gly Val Cys 
145                 150                 155                 160 
Lys Leu Asp Ser Ala Lys Thr His Gln Ala Val Glu Glu Arg Leu Gly 
                165                 170                 175     
Gly Pro Leu Ser Asp Leu Ser Gln Arg Tyr Ala Lys Pro Phe Ala Gln 
            180                 185                 190         
Met Gly Glu Val Leu Asn Phe Ala Ala Ser Pro Tyr Cys Lys Ser Leu 
        195                 200                 205             
Gln Lys Asn Gly Lys Thr Cys Asp Phe Ala Thr Phe Thr Ala Asn Glu 
    210                 215                 220                 
Ile Lys Val Asn Glu Arg Gly Thr Lys Val Ser Leu Ser Gly Pro Leu 
225                 230                 235                 240 
Ala Leu Ser Ser Thr Leu Gly Glu Ile Phe Leu Leu Gln Asp Ser Gln 
                245                 250                 255     
Ala Met Pro Asp Val Ala Trp His Arg Leu Ser Gly Glu Glu Asn Trp 
            260                 265                 270         
Val Ser Leu Leu Ser Leu Arg Asn Ala Gln Phe Asp Leu Met Ala Lys 
        275                 280                 285             
Thr Pro Tyr Ile Ala Arg His Lys Gly Thr Pro Leu Leu Gln Gln Ile 
    290                 295                 300                 
Asp Thr Ala Leu Val Leu Gln Arg Asp Ala Gln Gly Gln Thr Leu Pro 
305                 310                 315                 320 
Leu Ser Pro Gln Thr Lys Leu Leu Phe Leu Gly Gly His Asp Thr Asn 
                325                 330                 335     
Ile Ala Asn Ile Ala Gly Met Leu Gly Ala Asn Trp Gln Leu Pro Gln 
            340                 345                 350         
Gln Pro Asp Asn Thr Pro Pro Gly Gly Gly Leu Val Phe Glu Leu Trp 
        355                 360                 365             
Gln Asn Pro Asp Asn His Gln Arg Tyr Val Ala Val Lys Met Phe Tyr 
    370                 375                 380                 
Gln Thr Met Asp Gln Leu Arg Asn Ala Glu Lys Leu Asp Met Lys Asn 
385                 390                 395                 400 
Asn Pro Ala Lys Ile Val Pro Ile Thr Ile Glu Gly Cys Glu Asn Glu 
                405                 410                 415     
Gly Asp Asn Lys Leu Cys Gln Leu Glu Thr Phe Gln Lys Lys Val Ala 
            420                 425                 430         
Gln Val Ile Glu Pro Ala Cys His Ile 
        435                 440     

<210>  8
<211>  1326
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
atgtcagttg caaagagaaa tctgcactta tccgcactca ctttgataat gggctgtttt        60
accgcaggtg ctgccccgat tgctacaccg ccggccagct acacattaga gcgtgtggtt       120
attttgagtc gacatggtgt tcgctccccg acaaaacaaa cccagctaat gaatgatgtc       180
acacctgata aatggcccct gtggccagta aaagcgggct atttaacacc gcgaagggct       240
gagttagtga ctttgatggg gggattttat ggtgattatt tccgcagcca agggttgttg       300
tctgcggggt gtccggtaga tggctccgtt tatgcacagg cagatgttga ccaacgaacc       360
cgcttaaccg gacaggcatt cttggatggg atcgcaccgg attgtggtct gaaagtacat       420
tatcaggctg atttgaagaa agttgacccg ctatttcata ccgtcgaagc gggggtctgt       480
aaaggcgact cagcgaaaac tcatcaggct gttgaggagc gattgggcgg gccattgagt       540
gatcttagcc agcgctatgc caaacccttt gctcagatgg gcgaagtgct gaattttgca       600
gcatcgcctt attgcaagtc attgcaaaaa aatggaaaaa cctgtgattt tgcaactttt       660
acggcaaatg aaattaaggt aaacgaagaa ggtactaaag tttctctgag tgggccattg       720
gcactatcgt cgacattggg tgaaattttc ctgttacaag actcacaagc tatgccggat       780
gtggcctggc atcggctcag cggtgaagag aactgggttt cgctattgtc gttgcgcaat       840
gcgcaatttg atttgatggc caaaaccccg tatatcgctc gccataaagg gaccccgctg       900
ttgcaacaaa ttgatacggc attagtgctg caacgcgatg cccaagggca aacactgccg       960
ctgtcaccgc aaaccaaatt gctgttcctc ggcgggcatg acaccaatat tgctaatatc      1020
gctggtatgt taggggccaa ttggcaatta ccacagcaac ctgataatac cccgcctggt      1080
ggcggattag tctttgagct atggcagaac ccagataatc atcagcgcta tgtcgccgtg      1140
aaaatgttct atcaaacgat ggatcagctg cgaaatgccg agaaattaga tatgaaaaac      1200
aacccagcta aaattgttcc aattaccatt gaaggttgtg agaacgaggg tgataacaaa      1260
ctttgccaac ttgagacttt ccaaaagaaa gttgcccaag tgatcgagcc agcctgccat      1320
atttaa                                                                 1326

<210>  9
<211>  1326
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  9
atgtcagttg caaagagaaa tctgcactta tccgcactca ctttgataat gggctgtttt        60
accgcaggtg ctgccccgat tgctacaccg ccggccagct acacattaga gcgtgtggtt       120
attttgagtc gacatggtgt tcgctccccg acaaaacaaa cccagctaat gaatgatgtc       180
acacctgata aatggcccct gtggccagta aaagcgggct atttaacacc gcgaagggct       240
gagttagtga ctttgatggg gggattttat ggtgattatt tccgcagcca agggttgttg       300
tctgcggggt gtccggtaga tggctccgtt tatgcacagg cagatgttga ccaacgaacc       360
cgcttaaccg gacaggcatt cttggatggg atcgcaccgg attgtggtct gaaagtacat       420
tatcaggctg atttgaagaa agttgacccg ctatttcata ccgtcgaagc gggggtctgt       480
aaagcggact cagcgaaaac tcatcaggct gttgaggagc gattgggcgg gccattgagt       540
gatcttagcc agcgctatgc caaacccttt gctcagatgg gcgaagtgct gaattttgca       600
gcatcgcctt attgcaagtc attgcaaaaa aatggaaaaa cctgtgattt tgcaactttt       660
acggcaaatg aaattaaggt aaacgaagaa ggtactaaag tttctctgag tgggccattg       720
gcactatcgt cgacattggg tgaaattttc ctgttacaag actcacaagc tatgccggat       780
gtggcctggc atcggctcag cggtgaagag aactgggttt cgctattgtc gttgcgcaat       840
gcgcaatttg atttgatggc caaaaccccg tatatcgctc gccataaagg gaccccgctg       900
ttgcaacaaa ttgatacggc attagtgctg caacgcgatg cccaagggca aacactgccg       960
ctgtcaccgc aaaccaaatt gctgttcctc ggcgggcatg acaccaatat tgctaatatc      1020
gctggtatgt taggggccaa ttggcaatta ccacagcaac ctgataatac cccgcctggt      1080
ggcggattag tctttgagct atggcagaac ccagataatc atcagcgcta tgtcgccgtg      1140
aaaatgttct atcaaacgat ggatcagctg cgaaatgccg agaaattaga tatgaaaaac      1200
aacccagcta aaattgttcc aattaccatt gaaggttgtg agaacgaggg tgataacaaa      1260
ctttgccaac ttgagacttt ccaaaagaaa gttgcccaag tgatcgagcc agcctgccat      1320
atttaa                                                                 1326

<210>  10
<211>  1326
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
atgtcagttg caaagagaaa tctgcactta tccgcactca ctttgataat gggctgtttt        60
accgcaggtg ctgccccgat tgctacaccg ccggccagct acacattaga gcgtgtggtt       120
attttgagtc gacatggtgt tcgctccccg acaaaacaaa cccagctaat gaatgatgtc       180
acacctgata aatggcccct gtggccagta aaagcgggct atttaacacc gcgaagggct       240
gagttagtga ctttgatggg gggattttat ggtgattatt tccgcagcca agggttgttg       300
tctgcggggt gtccggtaga tggctccgtt tatgcacagg cagatgttga ccaacgaacc       360
cgcttaaccg gacaggcatt cttggatggg atcgcaccgg attgtggtct gaaagtacat       420
tatcaggctg atttgaagaa agttgacccg ctatttcata ccgtcgaagc gggggtctgt       480
aaactggact cagcgaaaac tcatcaggct gttgaggagc gattgggcgg gccattgagt       540
gatcttagcc agcgctatgc caaacccttt gctcagatgg gcgaagtgct gaattttgca       600
gcatcgcctt attgcaagtc attgcaaaaa aatggaaaaa cctgtgattt tgcaactttt       660
acggcaaatg aaattaaggt aaacgaaggc ggtactaaag tttctctgag tgggccattg       720
gcactatcgt cgacattggg tgaaattttc ctgttacaag actcacaagc tatgccggat       780
gtggcctggc atcggctcag cggtgaagag aactgggttt cgctattgtc gttgcgcaat       840
gcgcaatttg atttgatggc caaaaccccg tatatcgctc gccataaagg gaccccgctg       900
ttgcaacaaa ttgatacggc attagtgctg caacgcgatg cccaagggca aacactgccg       960
ctgtcaccgc aaaccaaatt gctgttcctc ggcgggcatg acaccaatat tgctaatatc      1020
gctggtatgt taggggccaa ttggcaatta ccacagcaac ctgataatac cccgcctggt      1080
ggcggattag tctttgagct atggcagaac ccagataatc atcagcgcta tgtcgccgtg      1140
aaaatgttct atcaaacgat ggatcagctg cgaaatgccg agaaattaga tatgaaaaac      1200
aacccagcta aaattgttcc aattaccatt gaaggttgtg agaacgaggg tgataacaaa      1260
ctttgccaac ttgagacttt ccaaaagaaa gttgcccaag tgatcgagcc agcctgccat      1320
atttaa                                                                 1326

<210>  11
<211>  1326
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  11
atgtcagttg caaagagaaa tctgcactta tccgcactca ctttgataat gggctgtttt        60
accgcaggtg ctgccccgat tgctacaccg ccggccagct acacattaga gcgtgtggtt       120
attttgagtc gacatggtgt tcgctccccg acaaaacaaa cccagctaat gaatgatgtc       180
acacctgata aatggcccct gtggccagta aaagcgggct atttaacacc gcgaagggct       240
gagttagtga ctttgatggg gggattttat ggtgattatt tccgcagcca agggttgttg       300
tctgcggggt gtccggtaga tggctccgtt tatgcacagg cagatgttga ccaacgaacc       360
cgcttaaccg gacaggcatt cttggatggg atcgcaccgg attgtggtct gaaagtacat       420
tatcaggctg atttgaagaa agttgacccg ctatttcata ccgtcgaagc gggggtctgt       480
aaactggact cagcgaaaac tcatcaggct gttgaggagc gattgggcgg gccattgagt       540
gatcttagcc agcgctatgc caaacccttt gctcagatgg gcgaagtgct gaattttgca       600
gcatcgcctt attgcaagtc attgcaaaaa aatggaaaaa cctgtgattt tgcaactttt       660
acggcaaatg aaattaaggt aaacgaaccg ggtactaaag tttctctgag tgggccattg       720
gcactatcgt cgacattggg tgaaattttc ctgttacaag actcacaagc tatgccggat       780
gtggcctggc atcggctcag cggtgaagag aactgggttt cgctattgtc gttgcgcaat       840
gcgcaatttg atttgatggc caaaaccccg tatatcgctc gccataaagg gaccccgctg       900
ttgcaacaaa ttgatacggc attagtgctg caacgcgatg cccaagggca aacactgccg       960
ctgtcaccgc aaaccaaatt gctgttcctc ggcgggcatg acaccaatat tgctaatatc      1020
gctggtatgt taggggccaa ttggcaatta ccacagcaac ctgataatac cccgcctggt      1080
ggcggattag tctttgagct atggcagaac ccagataatc atcagcgcta tgtcgccgtg      1140
aaaatgttct atcaaacgat ggatcagctg cgaaatgccg agaaattaga tatgaaaaac      1200
aacccagcta aaattgttcc aattaccatt gaaggttgtg agaacgaggg tgataacaaa      1260
ctttgccaac ttgagacttt ccaaaagaaa gttgcccaag tgatcgagcc agcctgccat      1320
atttaa                                                                 1326

<210>  12
<211>  1326
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  12
atgtcagttg caaagagaaa tctgcactta tccgcactca ctttgataat gggctgtttt        60
accgcaggtg ctgccccgat tgctacaccg ccggccagct acacattaga gcgtgtggtt       120
attttgagtc gacatggtgt tcgctccccg acaaaacaaa cccagctaat gaatgatgtc       180
acacctgata aatggcccct gtggccagta aaagcgggct atttaacacc gcgaagggct       240
gagttagtga ctttgatggg gggattttat ggtgattatt tccgcagcca agggttgttg       300
tctgcggggt gtccggtaga tggctccgtt tatgcacagg cagatgttga ccaacgaacc       360
cgcttaaccg gacaggcatt cttggatggg atcgcaccgg attgtggtct gaaagtacat       420
tatcaggctg atttgaagaa agttgacccg ctatttcata ccgtcgaagc gggggtctgt       480
aaactggact cagcgaaaac tcatcaggct gttgaggagc gattgggcgg gccattgagt       540
gatcttagcc agcgctatgc caaacccttt gctcagatgg gcgaagtgct gaattttgca       600
gcatcgcctt attgcaagtc attgcaaaaa aatggaaaaa cctgtgattt tgcaactttt       660
acggcaaatg aaattaaggt aaacgaacgt ggtactaaag tttctctgag tgggccattg       720
gcactatcgt cgacattggg tgaaattttc ctgttacaag actcacaagc tatgccggat       780
gtggcctggc atcggctcag cggtgaagag aactgggttt cgctattgtc gttgcgcaat       840
gcgcaatttg atttgatggc caaaaccccg tatatcgctc gccataaagg gaccccgctg       900
ttgcaacaaa ttgatacggc attagtgctg caacgcgatg cccaagggca aacactgccg       960
ctgtcaccgc aaaccaaatt gctgttcctc ggcgggcatg acaccaatat tgctaatatc      1020
gctggtatgt taggggccaa ttggcaatta ccacagcaac ctgataatac cccgcctggt      1080
ggcggattag tctttgagct atggcagaac ccagataatc atcagcgcta tgtcgccgtg      1140
aaaatgttct atcaaacgat ggatcagctg cgaaatgccg agaaattaga tatgaaaaac      1200
aacccagcta aaattgttcc aattaccatt gaaggttgtg agaacgaggg tgataacaaa      1260
ctttgccaac ttgagacttt ccaaaagaaa gttgcccaag tgatcgagcc agcctgccat      1320
atttaa                                                                 1326

