﻿                         序列表

<110>  广东溢多利生物科技股份有限公司

<120>  提高比活的α-淀粉酶BasAmy突变体及其编码基因和应用

<160>  10

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1536
<212>  DNA
<213>  索诺拉沙漠芽胞杆菌

<400>  1
atggtttaca aatgcaaacg gatattatgt tgtgtgctgc tgtttttcat agtgctgccg        60
gcttctaaaa catatgcggc aagcctgaac ggcacgctga tgcagtattt tgaatggaat       120
ctgcctaatg acggccagca ttggaagcgc ttacaaaatg atgcgggata tttatccgac       180
attgggataa cggctgtttg gattccgccc gcctacaagg gaacgagcca ggctgacgtt       240
ggatacggcc catacgattt gtacgattta ggggagttcc tgcaaaaagg gacggtgcgg       300
acgaaatacg ggatgaaaac agagcttcag tcagctgtcg gttcgcttca ttcccagaac       360
atccaagtgt atggcgatgt tgtccttaat cataaggctg gggcggatct gacggaggat       420
gtcaccgcgg ttgaagtgaa tcccggcaat cgaaatcagg aaatatctgg agaatatcga       480
atcaaagcgt ggacaggatt caatttccct ggacgcggca gcacatacag tgattttaaa       540
tggcattggt atcattttga tgggacggat tgggacgaat cccgaaagct gaatcgcatc       600
tacaagttcc gcggagatgg gaaggcatgg gattgggagg tttccagcga aaacggcaac       660
tacgattatt taatgtatgc ggatgtcgat tatgaccacc ccgatgttgt ggcagaaatg       720
aaacggtggg gaacctggta tgcaaaagag cttcaattgg atgggttccg gcttgatgcc       780
gtcaagcata ttaagttctc ttttctttct gattggttga aggctgtgcg tcagagcact       840
ggcaaggaaa tgtttacggt tgcggaatac tggcaaaata accttggaga aatcgaaaac       900
tacttgcaaa aaaccgattt tcaacattct gtattcgatg tgccgcttca ttttaacctt       960
caggccgcat cttcacacgg aggcagctat gatatgagga atttgctgaa cggaacggtt      1020
gtttccaaac atcctttgaa agcggttaca tttgtcgaca accatgacac acagccgggg      1080
caatcattgg agtcgaccgt ccaaacatgg ttcaagccgc ttgcctacgc ttttattttg      1140
acaagagagg ccgggtaccc gcaggttttt tatggagata tgtatgggac aaaaggtcct      1200
acatcgcggg aaattccttc tcttaaaagt aaactggagc cgattttgaa agcgcgcaag      1260
tattatgctt atggaacaca gcatgattat ttcgatcatc cagatgccat cggctggacg      1320
agggaaggcg atcaatccgt cgctgcatca ggcttggccg ctttaatcac agacggaccg      1380
ggcggatcaa agcggatgta tgtgggcagg cagcatgccg gtgagacatg gcatgacatc      1440
actgggaacc gttcagattc cgtcgtgatc aattcggacg gctggggaga gttttatgta      1500
aacggcggtt cggtttcgat ttatgtccaa cgatag                                1536

<210>  2
<211>  1536
<212>  DNA
<213>  人工序列

<400>  2
atggtttaca aatgcaaacg gatattatgt tgtgtgctgc tgtttttcat agtgctgccg        60
gcttctaaaa catatgcggc aagcgctaac ggcacgctga tgcagtattt tgaatggaat       120
ctgcctaatg acggccagca ttggaagcgc ttacaaaatg atgcgggata tttatccgac       180
attgggataa cggctgtttg gattccgccc gcctacaagg gaacgagcca ggctgacgtt       240
ggatacggcc catacgattt gtacgattta ggggagttcc tgcaaaaagg gacggtgcgg       300
acgaaatacg ggatgaaaac agagcttcag tcaagagtcg gttcgcttca ttcccagaac       360
atccaagtgt atggcgatgt tgtccttaat cataaggctg gggcggatct gacggaggat       420
gtcaccgcgg ttgaagtgaa tcccggcaat cgaaatcagg aaatatctgg agaatatcga       480
atcaaagcgt ggacaggatt caatttccct ggacgcggca gcacatacag tgattttaaa       540
tggcattggt atcattttga tgggacggat tgggacgaat cccgaaagct gaatcgcatc       600
tacaagttcc gcggagatgg gaaggcatgg gattgggagg tttccagcga aaacggcaac       660
tacgattatt taatgtatgc ggatgtcgat tatgaccacc ccgatgttgt ggcagaaatg       720
aaacggtggg gaacctggta tgcaaaagag cttcaattgg atgggttccg gcttgatgcc       780
gtcaagcata ttaagttcca gtttctttct gattggttgt cggctgtgcg ttctcagact       840
ggcaaggaaa tgtttacggt tgcggaatac tggcaaaata accttggaga aatcgaaaac       900
tacttgcaaa aaaccgattt tcaacattct gtattcgatg tgccgcttca ttttaacctt       960
caggccgcat cttcacacgg aggcagctat gatatgagga atttgctgaa cggaacggtt      1020
gtttccaaac atcctttgaa agcggttaca tttgtcgaca accatggtac acagccgggg      1080
caatcattgg agtcgaccgt ccaaacatgg ttcaagccgc ttgcctacgc ttttattttg      1140
acaagagagg ccgggtaccc gcaggttttt tatggagata tgtatgggac aaaaggtcct      1200
acatcgcggg aaattccttc tcttaaaagt aaatgtgagc cgattttgaa agcgcgcaag      1260
tattatgctt atggaacaca gcatgattat ttcgatcatc cagatgccat cggctggacg      1320
agggaaggcg atcaatccgt cgctgcatca ggcttggccg ctttaatcac agacggaccg      1380
ggcggatcaa agcggatgta tgtgggcagg cagcatgccg gtgagacatg gcatgacatc      1440
actgggaacc gttcagattc cgtcgtgatc aattcggacg gctggggaga gttttatgta      1500
aacggcggtt cggtttcgat ttatgtccaa cgatag                                1536

<210>  3
<211>  1536
<212>  DNA
<213>  人工序列

<400>  3
atggtttaca aatgcaaacg gatattatgt tgtgtgctgc tgtttttcat agtgctgccg        60
gcttctaaaa catatgcggc aagcgctaac ggcacgctga tgcagtattt tgaatggaat       120
ctgcctaatg acggccagca ttggaagcgc ttacaaaatg atgcgggata tttatccgac       180
attgggataa cggctgtttg gattccgccc gcctacaagg gaacgagcca ggctgacgtt       240
ggatacggcc catacgattt gtacgattta ggggagttcc tgcaaaaagg gacggtgcgg       300
acgaaatacg ggatgaaaac agagcttcag tcagctgtcg gttcgcttca ttcccagaac       360
atccaagtgt atggcgatgt tgtccttaat cataaggctg gggcggatct gacggaggat       420
gtcaccgcgg ttgaagtgaa tcccggcaat cgaaatcagg aaatatctgg agaatatcga       480
atcaaagcgt ggacaggatt caatttccct ggacgcggca gcacatacag tgattttaaa       540
tggcattggt atcattttga tgggacggat tgggacgaat cccgaaagct gaatcgcatc       600
tacaagttcc gcggagatgg gaaggcatgg gattgggagg tttccagcga aaacggcaac       660
tacgattatt taatgtatgc ggatgtcgat tatgaccacc ccgatgttgt ggcagaaatg       720
aaacggtggg gaacctggta tgcaaaagag cttcaattgg atgggttccg gcttgatgcc       780
gtcaagcata ttaagttctc tttttttcct gattggttga agtatgtgcg ttctcagact       840
ggcaaggaaa tgtttacggt tgcggaatac tggcaaaata accttggaga aatcgaaaac       900
tacttgcaaa aaaccgattt tcaacattct gtattcgatg tgccgcttca ttttaacctt       960
caggccgcat cttcacacgg aggcagctat gatatgagga atttgctgaa cggaacggtt      1020
gtttccaaac atcctttgaa agcggttaca tttgtcgaca accatggtac acagccgggg      1080
caatcattgg agtcgaccgt ccaaacatgg ttcaagccgc ttgcctacgc ttttattttg      1140
acaagagagg ccgggtaccc gcaggttttt tatggagata tgtatgggac aaaaggtcct      1200
acatcgcggg aaattccttc tcttaaaagt aaatgtgagc cgattttgaa agcgcgcaag      1260
tattatgctt atggaacaca gcatgattat ttcgatcatc cagatgccat cggctggacg      1320
agggaaggcg atcaatccgt cgctgcatca ggcttggccg ctttaatcac agacggaccg      1380
ggcggatcaa agcggatgta tgtgggcagg cagcatgccg gtgagacatg gcatgacatc      1440
actgggaacc gttcagattc cgtcgtgatc aattcggacg gctggggaga gttttatgta      1500
aacggcggtt cggtttcgat ttatgtccaa cgatag                                1536

<210>  4
<211>  1536
<212>  DNA
<213>  人工序列

<400>  4
atggtttaca aatgcaaacg gatattatgt tgtgtgctgc tgtttttcat agtgctgccg        60
gcttctaaaa catatgcggc aagcgctaac ggcacgctga tgcagtattt tgaatggaat       120
ctgcctaatg acggccagca ttggaagcgc ttacaaaatg atgcgggata tttatccgac       180
attgggataa cggctgtttg gattccgccc gcctacaagg gaacgagcca ggctgacgtt       240
ggatacggcc catacgattt gtacgattta ggggagttcc tgcaaaaagg gacggtgcgg       300
acgaaatacg ggatgaaaac agagcttcag tcaagagtcg gttcgcttca ttcccagaac       360
atccaagtgt atggcgatgt tgtccttaat cataaggctg gggcggatct gacggaggat       420
gtcaccgcgg ttgaagtgaa tcccggcaat cgaaatcagg aaatatctgg agaatatcga       480
atcaaagcgt ggacaggatt caatttccct ggacgcggca gcacatacag tgattttaaa       540
tggcattggt atcattttga tgggacggat tgggacgaat cccgaaagct gaatcgcatc       600
tacaagttcc gcggagatgg gaaggcatgg gattgggagg tttccagcga aaacggcaac       660
tacgattatt taatgtatgc ggatgtcgat tatgaccacc ccgatgttgt ggcagaaatg       720
aaacggtggg gaacctggta tgcaaaagag cttcaattgg atgggttccg gcttgatgcc       780
gtcaagcata ttaagttctc ttttttttct gattggttgt cgtatgtgcg ttctcagact       840
ggcaaggaaa tgtttacggt tgcggaatac tggcaaaata accttggaga aatcgaaaac       900
tacttgcaaa aaaccgattt tcaacattct gtattcgatg tgccgcttca ttttaacctt       960
caggccgcat cttcacacgg aggcagctat gatatgagga atttgctgaa cggaacggtt      1020
gtttccaaac atcctttgaa agcggttaca tttgtcgaca accatgacac acagccgggg      1080
caatcattgg agtcgaccgt ccaaacatgg ttcaagccgc ttgcctacgc ttttattttg      1140
acaagagagg ccgggtaccc gcaggttttt tatggagata tgtatgggac aaaaggtcct      1200
acatcgcggg aaattccttc tcttaaaagt aaatgtgagc cgattttgaa agcgcgcaag      1260
tattatgctt atggaacaca gcatgattat ttcgatcatc cagatgccat cggctggacg      1320
agggaaggcg atcaatccgt cgctgcatca ggcttggccg ctttaatcac agacggaccg      1380
ggcggatcaa agcggatgta tgtgggcagg cagcatgccg gtgagacatg gcatgacatc      1440
actgggaacc gttcagattc cgtcgtgatc aattcggacg gctggggaga gttttatgta      1500
aacggcggtt cggtttcgat ttatgtccaa cgatag                                1536

<210>  5
<211>  1536
<212>  DNA
<213>  人工序列

<400>  5
atggtttaca aatgcaaacg gatattatgt tgtgtgctgc tgtttttcat agtgctgccg        60
gcttctaaaa catatgcggc aagcctgaac ggcacgctga tgcagtattt tgaatggaat       120
ctgcctaatg acggccagca ttggaagcgc ttacaaaatg atgcgggata tttatccgac       180
attgggataa cggctgtttg gattccgccc gcctacaagg gaacgagcca ggctgacgtt       240
ggatacggcc catacgattt gtacgattta ggggagttcc tgcaaaaagg gacggtgcgg       300
acgaaatacg ggatgaaaac agagcttcag tcagctgtcg gttcgcttca ttcccagaac       360
atccaagtgt atggcgatgt tgtccttaat cataaggctg gggcggatct gacggaggat       420
gtcaccgcgg ttgaagtgaa tcccggcaat cgaaatcagg aaatatctgg agaatatcga       480
atcaaagcgt ggacaggatt caatttccct ggacgcggca gcacatacag tgattttaaa       540
tggcattggt atcattttga tgggacggat tgggacgaat cccgaaagct gaatcgcatc       600
tacaagttcc gcggagatgg gaaggcatgg gattgggagg tttccagcga aaacggcaac       660
tacgattatt taatgtatgc ggatgtcgat tatgaccacc ccgatgttgt ggcagaaatg       720
aaacggtggg gaacctggta tgcaaaagag cttcaattgg atgggttccg gcttgatgcc       780
gtcaagcata ttaagttcca gttttttcct gattggttgt cgtatgtgcg ttctcagact       840
ggcaaggaaa tgtttacggt tgcggaatac tggcaaaata accttggaga aatcgaaaac       900
tacttgcaaa aaaccgattt tcaacattct gtattcgatg tgccgcttca ttttaacctt       960
caggccgcat cttcacacgg aggcagctat gatatgagga atttgctgaa cggaacggtt      1020
gtttccaaac atcctttgaa agcggttaca tttgtcgaca accatgacac acagccgggg      1080
caatcattgg agtcgaccgt ccaaacatgg ttcaagccgc ttgcctacgc ttttattttg      1140
acaagagagg ccgggtaccc gcaggttttt tatggagata tgtatgggac aaaaggtcct      1200
acatcgcggg aaattccttc tcttaaaagt aaatgtgagc cgattttgaa agcgcgcaag      1260
tattatgctt atggaacaca gcatgattat ttcgatcatc cagatgccat cggctggacg      1320
agggaaggcg atcaatccgt cgctgcatca ggcttggccg ctttaatcac agacggaccg      1380
ggcggatcaa agcggatgta tgtgggcagg cagcatgccg gtgagacatg gcatgacatc      1440
actgggaacc gttcagattc cgtcgtgatc aattcggacg gctggggaga gttttatgta      1500
aacggcggtt cggtttcgat ttatgtccaa cgatag                                1536

<210>  6
<211>  511
<212>  PRT
<213>  索诺拉沙漠芽胞杆菌

<400>  6
Met Val Tyr Lys Cys Lys Arg Ile Leu Cys Cys Val Leu Leu Phe Phe 
1               5                   10                  15      
Ile Val Leu Pro Ala Ser Lys Thr Tyr Ala Ala Ser Leu Asn Gly Thr 
            20                  25                  30          
Leu Met Gln Tyr Phe Glu Trp Asn Leu Pro Asn Asp Gly Gln His Trp 
        35                  40                  45              
Lys Arg Leu Gln Asn Asp Ala Gly Tyr Leu Ser Asp Ile Gly Ile Thr 
    50                  55                  60                  
Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Thr Ser Gln Ala Asp Val 
65                  70                  75                  80  
Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu Phe Leu Gln Lys 
                85                  90                  95      
Gly Thr Val Arg Thr Lys Tyr Gly Met Lys Thr Glu Leu Gln Ser Ala 
            100                 105                 110         
Val Gly Ser Leu His Ser Gln Asn Ile Gln Val Tyr Gly Asp Val Val 
        115                 120                 125             
Leu Asn His Lys Ala Gly Ala Asp Leu Thr Glu Asp Val Thr Ala Val 
    130                 135                 140                 
Glu Val Asn Pro Gly Asn Arg Asn Gln Glu Ile Ser Gly Glu Tyr Arg 
145                 150                 155                 160 
Ile Lys Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg Gly Ser Thr Tyr 
                165                 170                 175     
Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly Thr Asp Trp Asp 
            180                 185                 190         
Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg Gly Asp Gly Lys 
        195                 200                 205             
Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn Tyr Asp Tyr Leu 
    210                 215                 220                 
Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp Val Val Ala Glu Met 
225                 230                 235                 240 
Lys Arg Trp Gly Thr Trp Tyr Ala Lys Glu Leu Gln Leu Asp Gly Phe 
                245                 250                 255     
Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe Leu Ser Asp Trp 
            260                 265                 270         
Leu Lys Ala Val Arg Gln Ser Thr Gly Lys Glu Met Phe Thr Val Ala 
        275                 280                 285             
Glu Tyr Trp Gln Asn Asn Leu Gly Glu Ile Glu Asn Tyr Leu Gln Lys 
    290                 295                 300                 
Thr Asp Phe Gln His Ser Val Phe Asp Val Pro Leu His Phe Asn Leu 
305                 310                 315                 320 
Gln Ala Ala Ser Ser His Gly Gly Ser Tyr Asp Met Arg Asn Leu Leu 
                325                 330                 335     
Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ala Val Thr Phe Val 
            340                 345                 350         
Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln 
        355                 360                 365             
Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Glu Ala 
    370                 375                 380                 
Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Pro 
385                 390                 395                 400 
Thr Ser Arg Glu Ile Pro Ser Leu Lys Ser Lys Leu Glu Pro Ile Leu 
                405                 410                 415     
Lys Ala Arg Lys Tyr Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe Asp 
            420                 425                 430         
His Pro Asp Ala Ile Gly Trp Thr Arg Glu Gly Asp Gln Ser Val Ala 
        435                 440                 445             
Ala Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly Ser Lys 
    450                 455                 460                 
Arg Met Tyr Val Gly Arg Gln His Ala Gly Glu Thr Trp His Asp Ile 
465                 470                 475                 480 
Thr Gly Asn Arg Ser Asp Ser Val Val Ile Asn Ser Asp Gly Trp Gly 
                485                 490                 495     
Glu Phe Tyr Val Asn Gly Gly Ser Val Ser Ile Tyr Val Gln Arg 
            500                 505                 510     

<210>  7
<211>  511
<212>  PRT
<213>  人工序列

<400>  7
Met Val Tyr Lys Cys Lys Arg Ile Leu Cys Cys Val Leu Leu Phe Phe 
1               5                   10                  15      
Ile Val Leu Pro Ala Ser Lys Thr Tyr Ala Ala Ser Ala Asn Gly Thr 
            20                  25                  30          
Leu Met Gln Tyr Phe Glu Trp Asn Leu Pro Asn Asp Gly Gln His Trp 
        35                  40                  45              
Lys Arg Leu Gln Asn Asp Ala Gly Tyr Leu Ser Asp Ile Gly Ile Thr 
    50                  55                  60                  
Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Thr Ser Gln Ala Asp Val 
65                  70                  75                  80  
Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu Phe Leu Gln Lys 
                85                  90                  95      
Gly Thr Val Arg Thr Lys Tyr Gly Met Lys Thr Glu Leu Gln Ser Arg 
            100                 105                 110         
Val Gly Ser Leu His Ser Gln Asn Ile Gln Val Tyr Gly Asp Val Val 
        115                 120                 125             
Leu Asn His Lys Ala Gly Ala Asp Leu Thr Glu Asp Val Thr Ala Val 
    130                 135                 140                 
Glu Val Asn Pro Gly Asn Arg Asn Gln Glu Ile Ser Gly Glu Tyr Arg 
145                 150                 155                 160 
Ile Lys Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg Gly Ser Thr Tyr 
                165                 170                 175     
Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly Thr Asp Trp Asp 
            180                 185                 190         
Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg Gly Asp Gly Lys 
        195                 200                 205             
Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn Tyr Asp Tyr Leu 
    210                 215                 220                 
Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp Val Val Ala Glu Met 
225                 230                 235                 240 
Lys Arg Trp Gly Thr Trp Tyr Ala Lys Glu Leu Gln Leu Asp Gly Phe 
                245                 250                 255     
Arg Leu Asp Ala Val Lys His Ile Lys Phe Gln Phe Leu Ser Asp Trp 
            260                 265                 270         
Leu Ser Ala Val Arg Ser Gln Thr Gly Lys Glu Met Phe Thr Val Ala 
        275                 280                 285             
Glu Tyr Trp Gln Asn Asn Leu Gly Glu Ile Glu Asn Tyr Leu Gln Lys 
    290                 295                 300                 
Thr Asp Phe Gln His Ser Val Phe Asp Val Pro Leu His Phe Asn Leu 
305                 310                 315                 320 
Gln Ala Ala Ser Ser His Gly Gly Ser Tyr Asp Met Arg Asn Leu Leu 
                325                 330                 335     
Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ala Val Thr Phe Val 
            340                 345                 350         
Asp Asn His Gly Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln 
        355                 360                 365             
Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Glu Ala 
    370                 375                 380                 
Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Pro 
385                 390                 395                 400 
Thr Ser Arg Glu Ile Pro Ser Leu Lys Ser Lys Cys Glu Pro Ile Leu 
                405                 410                 415     
Lys Ala Arg Lys Tyr Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe Asp 
            420                 425                 430         
His Pro Asp Ala Ile Gly Trp Thr Arg Glu Gly Asp Gln Ser Val Ala 
        435                 440                 445             
Ala Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly Ser Lys 
    450                 455                 460                 
Arg Met Tyr Val Gly Arg Gln His Ala Gly Glu Thr Trp His Asp Ile 
465                 470                 475                 480 
Thr Gly Asn Arg Ser Asp Ser Val Val Ile Asn Ser Asp Gly Trp Gly 
                485                 490                 495     
Glu Phe Tyr Val Asn Gly Gly Ser Val Ser Ile Tyr Val Gln Arg 
            500                 505                 510     

<210>  8
<211>  511
<212>  PRT
<213>  人工序列

<400>  8
Met Val Tyr Lys Cys Lys Arg Ile Leu Cys Cys Val Leu Leu Phe Phe 
1               5                   10                  15      
Ile Val Leu Pro Ala Ser Lys Thr Tyr Ala Ala Ser Ala Asn Gly Thr 
            20                  25                  30          
Leu Met Gln Tyr Phe Glu Trp Asn Leu Pro Asn Asp Gly Gln His Trp 
        35                  40                  45              
Lys Arg Leu Gln Asn Asp Ala Gly Tyr Leu Ser Asp Ile Gly Ile Thr 
    50                  55                  60                  
Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Thr Ser Gln Ala Asp Val 
65                  70                  75                  80  
Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu Phe Leu Gln Lys 
                85                  90                  95      
Gly Thr Val Arg Thr Lys Tyr Gly Met Lys Thr Glu Leu Gln Ser Ala 
            100                 105                 110         
Val Gly Ser Leu His Ser Gln Asn Ile Gln Val Tyr Gly Asp Val Val 
        115                 120                 125             
Leu Asn His Lys Ala Gly Ala Asp Leu Thr Glu Asp Val Thr Ala Val 
    130                 135                 140                 
Glu Val Asn Pro Gly Asn Arg Asn Gln Glu Ile Ser Gly Glu Tyr Arg 
145                 150                 155                 160 
Ile Lys Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg Gly Ser Thr Tyr 
                165                 170                 175     
Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly Thr Asp Trp Asp 
            180                 185                 190         
Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg Gly Asp Gly Lys 
        195                 200                 205             
Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn Tyr Asp Tyr Leu 
    210                 215                 220                 
Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp Val Val Ala Glu Met 
225                 230                 235                 240 
Lys Arg Trp Gly Thr Trp Tyr Ala Lys Glu Leu Gln Leu Asp Gly Phe 
                245                 250                 255     
Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe Phe Pro Asp Trp 
            260                 265                 270         
Leu Lys Tyr Val Arg Ser Gln Thr Gly Lys Glu Met Phe Thr Val Ala 
        275                 280                 285             
Glu Tyr Trp Gln Asn Asn Leu Gly Glu Ile Glu Asn Tyr Leu Gln Lys 
    290                 295                 300                 
Thr Asp Phe Gln His Ser Val Phe Asp Val Pro Leu His Phe Asn Leu 
305                 310                 315                 320 
Gln Ala Ala Ser Ser His Gly Gly Ser Tyr Asp Met Arg Asn Leu Leu 
                325                 330                 335     
Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ala Val Thr Phe Val 
            340                 345                 350         
Asp Asn His Gly Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln 
        355                 360                 365             
Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Glu Ala 
    370                 375                 380                 
Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Pro 
385                 390                 395                 400 
Thr Ser Arg Glu Ile Pro Ser Leu Lys Ser Lys Cys Glu Pro Ile Leu 
                405                 410                 415     
Lys Ala Arg Lys Tyr Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe Asp 
            420                 425                 430         
His Pro Asp Ala Ile Gly Trp Thr Arg Glu Gly Asp Gln Ser Val Ala 
        435                 440                 445             
Ala Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly Ser Lys 
    450                 455                 460                 
Arg Met Tyr Val Gly Arg Gln His Ala Gly Glu Thr Trp His Asp Ile 
465                 470                 475                 480 
Thr Gly Asn Arg Ser Asp Ser Val Val Ile Asn Ser Asp Gly Trp Gly 
                485                 490                 495     
Glu Phe Tyr Val Asn Gly Gly Ser Val Ser Ile Tyr Val Gln Arg 
            500                 505                 510     

<210>  9
<211>  511
<212>  PRT
<213>  人工序列

<400>  9
Met Val Tyr Lys Cys Lys Arg Ile Leu Cys Cys Val Leu Leu Phe Phe 
1               5                   10                  15      
Ile Val Leu Pro Ala Ser Lys Thr Tyr Ala Ala Ser Ala Asn Gly Thr 
            20                  25                  30          
Leu Met Gln Tyr Phe Glu Trp Asn Leu Pro Asn Asp Gly Gln His Trp 
        35                  40                  45              
Lys Arg Leu Gln Asn Asp Ala Gly Tyr Leu Ser Asp Ile Gly Ile Thr 
    50                  55                  60                  
Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Thr Ser Gln Ala Asp Val 
65                  70                  75                  80  
Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu Phe Leu Gln Lys 
                85                  90                  95      
Gly Thr Val Arg Thr Lys Tyr Gly Met Lys Thr Glu Leu Gln Ser Arg 
            100                 105                 110         
Val Gly Ser Leu His Ser Gln Asn Ile Gln Val Tyr Gly Asp Val Val 
        115                 120                 125             
Leu Asn His Lys Ala Gly Ala Asp Leu Thr Glu Asp Val Thr Ala Val 
    130                 135                 140                 
Glu Val Asn Pro Gly Asn Arg Asn Gln Glu Ile Ser Gly Glu Tyr Arg 
145                 150                 155                 160 
Ile Lys Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg Gly Ser Thr Tyr 
                165                 170                 175     
Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly Thr Asp Trp Asp 
            180                 185                 190         
Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg Gly Asp Gly Lys 
        195                 200                 205             
Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn Tyr Asp Tyr Leu 
    210                 215                 220                 
Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp Val Val Ala Glu Met 
225                 230                 235                 240 
Lys Arg Trp Gly Thr Trp Tyr Ala Lys Glu Leu Gln Leu Asp Gly Phe 
                245                 250                 255     
Arg Leu Asp Ala Val Lys His Ile Lys Phe Ser Phe Phe Ser Asp Trp 
            260                 265                 270         
Leu Ser Tyr Val Arg Ser Gln Thr Gly Lys Glu Met Phe Thr Val Ala 
        275                 280                 285             
Glu Tyr Trp Gln Asn Asn Leu Gly Glu Ile Glu Asn Tyr Leu Gln Lys 
    290                 295                 300                 
Thr Asp Phe Gln His Ser Val Phe Asp Val Pro Leu His Phe Asn Leu 
305                 310                 315                 320 
Gln Ala Ala Ser Ser His Gly Gly Ser Tyr Asp Met Arg Asn Leu Leu 
                325                 330                 335     
Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ala Val Thr Phe Val 
            340                 345                 350         
Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln 
        355                 360                 365             
Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Glu Ala 
    370                 375                 380                 
Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Pro 
385                 390                 395                 400 
Thr Ser Arg Glu Ile Pro Ser Leu Lys Ser Lys Cys Glu Pro Ile Leu 
                405                 410                 415     
Lys Ala Arg Lys Tyr Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe Asp 
            420                 425                 430         
His Pro Asp Ala Ile Gly Trp Thr Arg Glu Gly Asp Gln Ser Val Ala 
        435                 440                 445             
Ala Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly Ser Lys 
    450                 455                 460                 
Arg Met Tyr Val Gly Arg Gln His Ala Gly Glu Thr Trp His Asp Ile 
465                 470                 475                 480 
Thr Gly Asn Arg Ser Asp Ser Val Val Ile Asn Ser Asp Gly Trp Gly 
                485                 490                 495     
Glu Phe Tyr Val Asn Gly Gly Ser Val Ser Ile Tyr Val Gln Arg 
            500                 505                 510     

<210>  10
<211>  511
<212>  PRT
<213>  人工序列

<400>  10
Met Val Tyr Lys Cys Lys Arg Ile Leu Cys Cys Val Leu Leu Phe Phe 
1               5                   10                  15      
Ile Val Leu Pro Ala Ser Lys Thr Tyr Ala Ala Ser Leu Asn Gly Thr 
            20                  25                  30          
Leu Met Gln Tyr Phe Glu Trp Asn Leu Pro Asn Asp Gly Gln His Trp 
        35                  40                  45              
Lys Arg Leu Gln Asn Asp Ala Gly Tyr Leu Ser Asp Ile Gly Ile Thr 
    50                  55                  60                  
Ala Val Trp Ile Pro Pro Ala Tyr Lys Gly Thr Ser Gln Ala Asp Val 
65                  70                  75                  80  
Gly Tyr Gly Pro Tyr Asp Leu Tyr Asp Leu Gly Glu Phe Leu Gln Lys 
                85                  90                  95      
Gly Thr Val Arg Thr Lys Tyr Gly Met Lys Thr Glu Leu Gln Ser Ala 
            100                 105                 110         
Val Gly Ser Leu His Ser Gln Asn Ile Gln Val Tyr Gly Asp Val Val 
        115                 120                 125             
Leu Asn His Lys Ala Gly Ala Asp Leu Thr Glu Asp Val Thr Ala Val 
    130                 135                 140                 
Glu Val Asn Pro Gly Asn Arg Asn Gln Glu Ile Ser Gly Glu Tyr Arg 
145                 150                 155                 160 
Ile Lys Ala Trp Thr Gly Phe Asn Phe Pro Gly Arg Gly Ser Thr Tyr 
                165                 170                 175     
Ser Asp Phe Lys Trp His Trp Tyr His Phe Asp Gly Thr Asp Trp Asp 
            180                 185                 190         
Glu Ser Arg Lys Leu Asn Arg Ile Tyr Lys Phe Arg Gly Asp Gly Lys 
        195                 200                 205             
Ala Trp Asp Trp Glu Val Ser Ser Glu Asn Gly Asn Tyr Asp Tyr Leu 
    210                 215                 220                 
Met Tyr Ala Asp Val Asp Tyr Asp His Pro Asp Val Val Ala Glu Met 
225                 230                 235                 240 
Lys Arg Trp Gly Thr Trp Tyr Ala Lys Glu Leu Gln Leu Asp Gly Phe 
                245                 250                 255     
Arg Leu Asp Ala Val Lys His Ile Lys Phe Gln Phe Phe Pro Asp Trp 
            260                 265                 270         
Leu Ser Tyr Val Arg Ser Gln Thr Gly Lys Glu Met Phe Thr Val Ala 
        275                 280                 285             
Glu Tyr Trp Gln Asn Asn Leu Gly Glu Ile Glu Asn Tyr Leu Gln Lys 
    290                 295                 300                 
Thr Asp Phe Gln His Ser Val Phe Asp Val Pro Leu His Phe Asn Leu 
305                 310                 315                 320 
Gln Ala Ala Ser Ser His Gly Gly Ser Tyr Asp Met Arg Asn Leu Leu 
                325                 330                 335     
Asn Gly Thr Val Val Ser Lys His Pro Leu Lys Ala Val Thr Phe Val 
            340                 345                 350         
Asp Asn His Asp Thr Gln Pro Gly Gln Ser Leu Glu Ser Thr Val Gln 
        355                 360                 365             
Thr Trp Phe Lys Pro Leu Ala Tyr Ala Phe Ile Leu Thr Arg Glu Ala 
    370                 375                 380                 
Gly Tyr Pro Gln Val Phe Tyr Gly Asp Met Tyr Gly Thr Lys Gly Pro 
385                 390                 395                 400 
Thr Ser Arg Glu Ile Pro Ser Leu Lys Ser Lys Cys Glu Pro Ile Leu 
                405                 410                 415     
Lys Ala Arg Lys Tyr Tyr Ala Tyr Gly Thr Gln His Asp Tyr Phe Asp 
            420                 425                 430         
His Pro Asp Ala Ile Gly Trp Thr Arg Glu Gly Asp Gln Ser Val Ala 
        435                 440                 445             
Ala Ser Gly Leu Ala Ala Leu Ile Thr Asp Gly Pro Gly Gly Ser Lys 
    450                 455                 460                 
Arg Met Tyr Val Gly Arg Gln His Ala Gly Glu Thr Trp His Asp Ile 
465                 470                 475                 480 
Thr Gly Asn Arg Ser Asp Ser Val Val Ile Asn Ser Asp Gly Trp Gly 
                485                 490                 495     
Glu Phe Tyr Val Asn Gly Gly Ser Val Ser Ile Tyr Val Gln Arg 
            500                 505                 510     

