                         SEQUENCE LISTING

<110>  The Hospital for Sick Children
 
<120>  METHOD OF DIAGNOSING ARRHYTHMOGENIC RIGHT VENTRICULAR 
       CARDIOMYOPATHY

<130>  H8313030PCT

<140>  PCT/CA2018/050032
<141>  2018-01-12

<150>  US 62/446013
<151>  2017-01-13

<160>  32    

<170>  PatentIn version 3.3

<210>  1
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  1

Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu Ser 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  2

Gly Glu Asp Leu Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  3

Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn Val Thr Ser 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  4

Leu Asn Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  5

Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  6

Leu Ser Ala Ala His Thr Leu Val Met Lys Ile Asn Ala Thr Asp 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  7

Glu His Ser Ser Tyr Thr Leu Thr Val Glu Ala Arg Asp Gly Asn 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  8

Glu Gly Ile Val Thr Leu Ile Lys Glu Val Asp Tyr Glu Glu Met 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  9

Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val Ile Val Ala 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  10

Ser Val Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  11

Gly Asn Phe Gln Ala Phe Asp Glu Asp Thr Gly Leu Pro Ala His 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  12

Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu Asp Arg Asp 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  13

Leu Glu Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  14

Asp Ser Val Thr Ser Glu Ile Lys Leu Ala Lys Leu Pro Asp Phe 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  15

Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  16

Asp Ile Asn Asp Asn Cys Pro Thr Leu Ile Glu Pro Val Gln Thr 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  17

Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr Val Asn Val 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  18

Glu Tyr Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  19

Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu Cys Leu His 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  20

Cys Glu Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  21

Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile Val 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  22

His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  23

Gln Phe Thr Gly Ala Thr Gly Ala Ile Met Thr Thr Glu Thr Thr 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  24

Ala Ser Tyr Thr Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  25

Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser Gln Glu Glu Thr Glu 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  26

Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  27

Leu Lys Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  28

Leu Gly Gln Lys Ile Asp Ile Asn Lys Glu Ile Glu Gln Arg Gln 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  29

Pro Lys Ser Leu Gln Glu Ala Asn Ala Glu Lys Val Thr Gln Glu 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  30

Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val Ser Ser Arg 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Peptide of DSG2

<400>  31

Val Ile Gln Pro His Gly Gly Gly Ser Asn Pro Leu Glu Gly Thr 
1               5                   10                  15  


<210>  32
<211>  1118
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Arg Ser Pro Gly Arg Ala Tyr Ala Leu Leu Leu Leu Leu Ile 
1               5                   10                  15      


Cys Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg 
            20                  25                  30          


Asn Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys 
        35                  40                  45              


Arg Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu 
    50                  55                  60                  


Ser Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu 
65                  70                  75                  80  


Arg Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu 
                85                  90                  95      


Pro Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn 
            100                 105                 110         


Val Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr 
        115                 120                 125             


Gly Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu 
    130                 135                 140                 


Leu Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr 
145                 150                 155                 160 


Gln Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr 
                165                 170                 175     


Leu Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu 
            180                 185                 190         


Asn Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro 
        195                 200                 205             


Pro Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser 
    210                 215                 220                 


Val Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu 
225                 230                 235                 240 


Ala Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala 
                245                 250                 255     


Gln Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val 
            260                 265                 270         


Glu Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val 
        275                 280                 285             


Glu Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp 
    290                 295                 300                 


Asn Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr 
305                 310                 315                 320 


Phe His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu 
                325                 330                 335     


Ile Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val 
            340                 345                 350         


Ile Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr 
        355                 360                 365             


Lys Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu 
    370                 375                 380                 


Gly Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser 
385                 390                 395                 400 


Met Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe 
                405                 410                 415     


Asp Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu 
            420                 425                 430         


Asp Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys 
        435                 440                 445             


Leu Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr 
    450                 455                 460                 


Tyr Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr 
465                 470                 475                 480 


Ile Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys 
                485                 490                 495     


Pro Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr 
            500                 505                 510         


Val Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro 
        515                 520                 525             


Phe Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp 
    530                 535                 540                 


Lys Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu 
545                 550                 555                 560 


Lys Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln 
                565                 570                 575     


Gly Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu 
            580                 585                 590         


Cys Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val 
        595                 600                 605             


Gly Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu 
    610                 615                 620                 


Leu Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly 
625                 630                 635                 640 


Ala Lys Gly Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro 
                645                 650                 655     


Trp Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe 
            660                 665                 670         


Leu Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly 
        675                 680                 685             


Gly Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile 
    690                 695                 700                 


Val Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu 
705                 710                 715                 720 


His Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr 
                725                 730                 735     


Gly Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly 
            740                 745                 750         


Ala Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn 
        755                 760                 765             


Glu Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr 
    770                 775                 780                 


Glu Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser 
785                 790                 795                 800 


Gln Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe 
                805                 810                 815     


Ile Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys 
            820                 825                 830         


Phe Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn 
        835                 840                 845             


Lys Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn 
    850                 855                 860                 


Thr Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn 
865                 870                 875                 880 


Thr Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu 
                885                 890                 895     


Ala Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val 
            900                 905                 910         


Ser Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met 
        915                 920                 925             


Ala Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser 
    930                 935                 940                 


Thr Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser 
945                 950                 955                 960 


Leu Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp 
                965                 970                 975     


Gln Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile 
            980                 985                 990         


Gln Pro His Gly Gly Gly Ser Asn  Pro Leu Glu Gly Thr  Gln His Leu 
        995                 1000                 1005             


Gln Asp  Val Pro Tyr Val Met  Val Arg Glu Arg Glu  Ser Phe Leu 
    1010                 1015                 1020             


Ala Pro  Ser Ser Gly Val Gln  Pro Thr Leu Ala Met  Pro Asn Ile 
    1025                 1030                 1035             


Ala Val  Gly Gln Asn Val Thr  Val Thr Glu Arg Val  Leu Ala Pro 
    1040                 1045                 1050             


Ala Ser  Thr Leu Gln Ser Ser  Tyr Gln Ile Pro Thr  Glu Asn Ser 
    1055                 1060                 1065             


Met Thr  Ala Arg Asn Thr Thr  Val Ser Gly Ala Gly  Val Pro Gly 
    1070                 1075                 1080             


Pro Leu  Pro Asp Phe Gly Leu  Glu Glu Ser Gly His  Ser Asn Ser 
    1085                 1090                 1095             


Thr Ile  Thr Thr Ser Ser Thr  Arg Val Thr Lys His  Ser Thr Val 
    1100                 1105                 1110             


Gln His  Ser Tyr Ser 
    1115             


