                               SEQUENCE LISTING

<110> SYNLOGIC, INC. et al.
 
<120> MICROORGANISMS PROGRAMMED TO PRODUCE IMMUNE MODULATORS AND 
      ANTI-CANCER THERAPEUTICS IN TUMOR CELLS

<130> 126046-21320

<140>
<141>

<150> 62/607,210
<151> 2017-12-18

<150> 62/592,317
<151> 2017-11-29

<150> 62/552,319
<151> 2017-08-30

<150> 62/543,322
<151> 2017-08-09

<150> 62/531,784
<151> 2017-07-12

<150> PCT/US2017/013072
<151> 2017-01-11

<150> 62/443,634
<151> 2017-01-06

<150> 62/443,639
<151> 2017-01-06

<160> 1253  

<170> PatentIn version 3.5

<210> 1
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Heavy chain humanized

<400> 1
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 2
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Light chain humanized

<400> 2
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 3
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Heavy chain human monoclonal

<400> 3
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210> 4
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Light chain human monoclonal

<400> 4
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 5
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Ipilimumab, CTLA-4, Heavy chain

<400> 5
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 6
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Ipilimumab , CTLA-4, Heavy chain variable region

<400> 6
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 7
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Ipilimumab, CTLA-4, Light chain

<400> 7
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 8
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Ipilimumab, CTLA-4, Light chain variable region

<400> 8
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 9
<211> 411
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Tremelimumab (CP675206), CTLA-4, Heavy chain

<400> 9
Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser 
1               5                   10                  15      


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            20                  25                  30          


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        35                  40                  45              


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr 
    50                  55                  60                  


Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
65                  70                  75                  80  


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
                85                  90                  95      


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
            100                 105                 110         


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
        115                 120                 125             


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
    130                 135                 140                 


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
145                 150                 155                 160 


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
                165                 170                 175     


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
        195                 200                 205             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    210                 215                 220                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
225                 230                 235                 240 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                245                 250                 255     


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
            260                 265                 270         


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        275                 280                 285             


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
    290                 295                 300                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
305                 310                 315                 320 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                325                 330                 335     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            340                 345                 350         


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
        355                 360                 365             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    370                 375                 380                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
385                 390                 395                 400 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410     


<210> 10
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Tremelimumab (CP675206), CTLA-4, Light chain

<400> 10
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 11
<211> 442
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> PF-05082566, 4-1BB (CD137, TNFRSF9), Heavy chain

<400> 11
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe 
            180                 185                 190         


Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
            260                 265                 270         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
305                 310                 315                 320 


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            340                 345                 350         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                405                 410                 415     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440         


<210> 12
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> PF-05082566, 4-1BB (CD137, TNFRSF9), Light chain

<400> 12
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210> 13
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Urelumab, 4-1BB (CD137, TNFRSF9), Heavy chain

<400> 13
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210> 14
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Urelumab, 4-1BB (CD137, TNFRSF9), Light chain

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Cys Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210> 15
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-OX40 antibody (Providence Health and Services),
      CD134 (OX40), Heavy chain

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Ile His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Ser Gly Gly Leu Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Pro Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Glu Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 16
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-OX40 antibody (Providence Health and Services),
      CD134 (OX40), Light chain

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Thr Gln Ser Ile Tyr Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 17
<211> 440
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Nivolumab, PD-1, Heavy chain

<400> 17
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210> 18
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Nivolumab, PD-1, Heavy chain variable region

<400> 18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210> 19
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Nivolumab, PD-1, Light chain

<400> 19
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 20
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Nivolumab, PD-1, Light chain variable region

<400> 20
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 21
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Pidilizumab, PD-1, Heavy chain

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Asp Ser Gly Glu Ser Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Thr Ser Leu Thr Ala Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Val Arg Val Gly Tyr Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210> 22

<400> 22
000


<210> 23
<211> 213
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Pidilizumab, PD-1, Light chain

<400> 23
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Cys Leu Thr Ile Asn Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210> 24

<400> 24
000


<210> 25
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Pembrolizumab (MK-3475/SCH900475, lambrolizumab) PD-1,
      Heavy chain

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 26
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Pembrolizumab (MK-3475/SCH900475, lambrolizumab),
      PD-1, Light chain  Heavy chain variable region is 
      described in as described in WO2009114335

<400> 26
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210> 27
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Durvalumab (MEDI4736), PD-L1, Heavy chain

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 28
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Durvalumab (MEDI4736), PD-L1, Light chain

<400> 28
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 29
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Lirilumab, KIR, Heavy chain

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Phe Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Ile Pro Ile Phe Gly Ala Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Ser Gly Ser Tyr Tyr Tyr Asp Tyr Asp Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly Lys 
    450 


<210> 30
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Lirilumab, KIR, Light chain

<400> 30
Glu Ile Val Leu Thr Gln Ser Pro Val Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Met Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 31
<211> 447
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> BMS-986016, LAG3, Heavy chain

<400> 31
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Arg Gly Ser Thr Asn Ser Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Phe Gly Tyr Ser Asp Tyr Glu Tyr Asn Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210> 32
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> BMS986016, LAG3, Light chain

<400> 32
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 33
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Avelumab  (MSB0010718C), PD-L1, Heavy chain

<400> 33
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 34
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Avelumab  (MSB0010718C), PD-L1, Light chain

<400> 34
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210> 35
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Atezolizumab (MPDL3280A, RG7446,  RO5541267) PD-L1,
      Heavy chain

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 36
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Atezolizumab (MPDL3280A, RG7446, RO5541267) PD-L1,
      Heavy chain variable region

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 37
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Atezolizumab (MPDL3280A, RG7446,  RO5541267), PD-L1,
      Light chain

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 38
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Atezolizumab (MPDL3280A, RG7446, RO5541267), PD-L1,
      Light chain variable region

<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210> 39
<211> 449
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Mogamulizumab, CCR4, Heavy chain

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Ser Thr Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Gly Arg His Ser Asp Gly Asn Phe Ala Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210> 40
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Mogamulizumab, CCR4, Light chain

<400> 40
Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Arg Asn Ile Val His Ile 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser Leu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210> 41
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Varlilumab, CD27, Heavy chain

<400> 41
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Asn Trp Gly Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Ser Ser 
    450         


<210> 42
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Varlilumab, CD27, Light chain

<400> 42
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 43
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Ulocuplumab, CXCR4, Heavy chain

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Arg Ser Arg Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Gly Gln Pro Pro Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Leu Gly 
    450     


<210> 44
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Ulocuplumab, CXCR4, Light chain

<400> 44
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Val Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 45
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Bavituximab, Phosphatidyl Serine, Heavy chain

<400> 45
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Asp Pro Tyr Tyr Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Gly Gly Tyr Tyr Gly His Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 46
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Bavituxumab, Phosphatidyl Serine, Light chain

<400> 46
Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly Ser Arg 
1               5                   10                  15      


Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp 
            20                  25                  30          


Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Val Ser Ser Pro Pro Thr Phe 
        35                  40                  45              


Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Ser 
    50                  55                  60                  


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
65                  70                  75                  80  


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
                85                  90                  95      


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
            100                 105                 110         


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
        115                 120                 125             


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
    130                 135                 140                 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
145                 150                 155                 160 


Arg Gly Glu Cys 
                


<210> 47
<211> 7584
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Tet-regulated Tryptophan operon

<400> 47
taagacccac tttcacattt aagttgtttt tctaatccgc atatgatcaa ttcaaggccg       60

aataagaagg ctggctctgc accttggtga tcaaataatt cgatagcttg tcgtaataat      120

ggcggcatac tatcagtagt aggtgtttcc ctttcttctt tagcgacttg atgctcttga      180

tcttccaata cgcaacctaa agtaaaatgc cccacagcgc tgagtgcata taatgcattc      240

tctagtgaaa aaccttgttg gcataaaaag gctaattgat tttcgagagt ttcatactgt      300

ttttctgtag gccgtgtacc taaatgtact tttgctccat cgcgatgact tagtaaagca      360

catctaaaac ttttagcgtt attacgtaaa aaatcttgcc agctttcccc ttctaaaggg      420

caaaagtgag tatggtgcct atctaacatc tcaatggcta aggcgtcgag caaagcccgc      480

ttatttttta catgccaata caatgtaggc tgctctacac ctagcttctg ggcgagttta      540

cgggttgtta aaccttcgat tccgacctca ttaagcagct ctaatgcgct gttaatcact      600

ttacttttat ctaatctaga catcattaat tcctaatttt tgttgacact ctatcattga      660

tagagttatt ttaccactcc ctatcagtga tagagaaaag tgaactctag aaataatttt      720

gtttaacttt aagaaggaga tatacatatg caaacacaaa aaccgactct cgaactgcta      780

acctgcgaag gcgcttatcg cgacaacccg actgcgcttt ttcaccagtt gtgtggggat      840

cgtccggcaa cgctgctgct ggaatccgca gatatcgaca gcaaagatga tttaaaaagc      900

ctgctgctgg tagacagtgc gctgcgcatt acagcattaa gtgacactgt cacaatccag      960

gcgctttccg gcaatggaga agccctgttg acactactgg ataacgcctt gcctgcgggt     1020

gtggaaaatg aacaatcacc aaactgccgc gtactgcgct tcccgcctgt cagtccactg     1080

ctggatgaag acgcccgctt atgctccctt tcggtttttg acgctttccg cttattacag     1140

aatctgttga atgtaccgaa ggaagaacga gaagcaatgt tcttcggcgg cctgttctct     1200

tatgaccttg tggcgggatt tgaaaattta ccgcaactgt cagcggaaaa tagctgccct     1260

gatttctgtt tttatctcgc tgaaacgctg atggtgattg accatcagaa aaaaagcact     1320

cgtattcagg ccagcctgtt tgctccgaat gaagaagaaa aacaacgtct cactgctcgc     1380

ctgaacgaac tacgtcagca actgaccgaa gccgcgccgc cgctgccggt ggtttccgtg     1440

ccgcatatgc gttgtgaatg taaccagagc gatgaagagt tcggtggtgt agtgcgtttg     1500

ttgcaaaaag cgattcgcgc cggagaaatt ttccaggtgg tgccatctcg ccgtttctct     1560

ctgccctgcc cgtcaccgct ggcagcctat tacgtgctga aaaagagtaa tcccagcccg     1620

tacatgtttt ttatgcagga taatgatttc accctgtttg gcgcgtcgcc ggaaagttcg     1680

ctcaagtatg acgccaccag ccgccagatt gagatttacc cgattgccgg aacacgtcca     1740

cgcggtcgtc gtgccgatgg ttcgctggac agagacctcg acagccgcat cgaactggag     1800

atgcgtaccg atcataaaga gctttctgaa catctgatgc tggtggatct cgcccgtaat     1860

gacctggcac gcatttgcac acccggcagc cgctacgtcg ccgatctcac caaagttgac     1920

cgttactctt acgtgatgca cctagtctcc cgcgttgttg gtgagctgcg ccacgatctc     1980

gacgccctgc acgcttaccg cgcctgtatg aatatgggga cgttaagcgg tgcaccgaaa     2040

gtacgcgcta tgcagttaat tgccgaagca gaaggtcgtc gacgcggcag ctacggcggc     2100

gcggtaggtt attttaccgc gcatggcgat ctcgacacct gcattgtgat ccgctcggcg     2160

ctggtggaaa acggtatcgc caccgtgcaa gccggtgctg gcgtagtcct tgattctgtt     2220

ccgcagtcgg aagccgacga aactcgtaat aaagcccgcg ctgtactgcg cgctattgcc     2280

accgcgcatc atgcacagga gacgttctaa tggctgacat tctgctgctc gataatatcg     2340

actcttttac gtacaacctg gcagatcagt tgcgcagcaa tggtcataac gtggtgattt     2400

accgcaacca tattccggcg cagaccttaa ttgaacgcct ggcgacgatg agcaatccgg     2460

tgctgatgct ttctcctggc cccggtgtgc cgagcgaagc cggttgtatg ccggaactcc     2520

tcacccgctt gcgtggcaag ctgccaatta ttggcatttg cctcggacat caggcgattg     2580

tcgaagctta cgggggctat gtcggtcagg cgggcgaaat tcttcacggt aaagcgtcga     2640

gcattgaaca tgacggtcag gcgatgtttg ccggattaac aaacccgctg ccagtggcgc     2700

gttatcactc gctggttggc agtaacattc cggccggttt aaccatcaac gcccatttta     2760

atggcatggt gatggcggtg cgtcacgatg cagatcgcgt ttgtggattc cagttccatc     2820

cggaatccat tcttactacc cagggcgctc gcctgctgga acaaacgctg gcctgggcgc     2880

agcagaaact agagccaacc aacacgctgc aaccgattct ggaaaaactg tatcaggcac     2940

agacgcttag ccaacaagaa agccaccagc tgttttcagc ggtggtacgt ggcgagctga     3000

agccggaaca actggcggcg gcgctggtga gcatgaaaat tcgcggtgaa cacccgaacg     3060

agatcgccgg ggcagcaacc gcgctactgg aaaacgccgc gccattcccg cgcccggatt     3120

atctgtttgc cgatatcgtc ggtactggcg gtgacggcag caacagcatc aatatttcta     3180

ccgccagtgc gtttgtcgcc gcggcctgcg ggctgaaagt ggcgaaacac ggcaaccgta     3240

gcgtctccag taaatccggc tcgtcggatc tgctggcggc gttcggtatt aatcttgata     3300

tgaacgccga taaatcgcgc caggcgctgg atgagttagg cgtctgtttc ctctttgcgc     3360

cgaagtatca caccggattc cgccatgcga tgccggttcg ccagcaactg aaaacccgca     3420

ctctgttcaa cgtgctggga ccattgatta acccggcgca tccgccgctg gcgctaattg     3480

gtgtttatag tccggaactg gtgctgccga ttgccgaaac cttgcgcgtg ctggggtatc     3540

aacgcgcggc agtggtgcac agcggcggga tggatgaagt ttcattacac gcgccgacaa     3600

tcgttgccga actacatgac ggcgaaatta agagctatca attgaccgct gaagattttg     3660

gcctgacacc ctaccaccag gagcaattgg caggcggaac accggaagaa aaccgtgaca     3720

ttttaacacg cttgttacaa ggtaaaggcg acgccgccca tgaagcagcc gtcgcggcga     3780

atgtcgccat gttaatgcgc ctgcatggcc atgaagatct gcaagccaat gcgcaaaccg     3840

ttcttgaggt actgcgcagt ggttccgctt acgacagagt caccgcactg gcggcacgag     3900

ggtaaatgat gcaaaccgtt ttagcgaaaa tcgtcgcaga caaggcgatt tgggtagaaa     3960

cccgcaaaga gcagcaaccg ctggccagtt ttcagaatga ggttcagccg agcacgcgac     4020

atttttatga tgcacttcag ggcgcacgca cggcgtttat tctggagtgt aaaaaagcgt     4080

cgccgtcaaa aggcgtgatc cgtgatgatt tcgatccggc acgcattgcc gccatttata     4140

aacattacgc ttcggcaatt tcagtgctga ctgatgagaa atattttcag gggagctttg     4200

atttcctccc catcgtcagc caaatcgccc cgcagccgat tttatgtaaa gacttcatta     4260

tcgatcctta ccagatctat ctggcgcgct attaccaggc cgatgcctgc ttattaatgc     4320

tttcagtact ggatgacgaa caatatcgcc agcttgcagc cgtcgcccac agtctggaga     4380

tgggtgtgct gaccgaagtc agtaatgaag aggaactgga gcgcgccatt gcattggggg     4440

caaaggtcgt tggcatcaac aaccgcgatc tgcgcgattt gtcgattgat ctcaaccgta     4500

cccgcgagct tgcgccgaaa ctggggcaca acgtgacggt aatcagcgaa tccggcatca     4560

atacttacgc tcaggtgcgc gagttaagcc acttcgctaa cggctttctg attggttcgg     4620

cgttgatggc ccatgacgat ttgaacgccg ccgtgcgtcg ggtgttgctg ggtgagaata     4680

aagtatgtgg cctgacacgt gggcaagatg ctaaagcagc ttatgacgcg ggcgcgattt     4740

acggtgggtt gatttttgtt gcgacatcac cgcgttgcgt caacgttgaa caggcgcagg     4800

aagtgatggc tgcagcaccg ttgcagtatg ttggcgtgtt ccgcaatcac gatattgccg     4860

atgtggcgga caaagctaag gtgttatcgc tggcggcagt gcaactgcat ggtaatgaag     4920

atcagctgta tatcgacaat ctgcgtgagg ctctgccagc acacgtcgcc atctggaagg     4980

ctttaagtgt cggtgaaact cttcccgcgc gcgattttca gcacatcgat aaatatgtat     5040

tcgacaacgg tcagggcggg agcggacaac gtttcgactg gtcactatta aatggtcaat     5100

cgcttggcaa cgttctgctg gcggggggct taggcgcaga taactgcgtg gaagcggcac     5160

aaaccggctg cgccgggctt gattttaatt ctgctgtaga gtcgcaaccg ggtatcaaag     5220

acgcacgtct tttggcctcg gttttccaga cgctgcgcgc atattaagga aaggaacaat     5280

gacaacatta cttaacccct attttggtga gtttggcggc atgtacgtgc cacaaatcct     5340

gatgcctgct ctgcgccagc tggaagaagc ttttgtcagc gcgcaaaaag atcctgaatt     5400

tcaggctcag ttcaacgacc tgctgaaaaa ctatgccggg cgtccaaccg cgctgaccaa     5460

atgccagaac attacagccg ggacgaacac cacgctgtat ctgaagcgcg aagatttgct     5520

gcacggcggc gcgcataaaa ctaaccaggt gctcggtcag gctttactgg cgaagcggat     5580

gggtaaaact gaaattattg ccgaaaccgg tgccggtcag catggcgtgg cgtcggccct     5640

tgccagcgcc ctgctcggcc tgaaatgccg aatttatatg ggtgccaaag acgttgaacg     5700

ccagtcgccc aacgttttcc ggatgcgctt aatgggtgcg gaagtgatcc cggtacatag     5760

cggttccgcg accctgaaag atgcctgtaa tgaggcgcta cgcgactggt ccggcagtta     5820

tgaaaccgcg cactatatgc tgggtaccgc agctggcccg catccttacc cgaccattgt     5880

gcgtgagttt cagcggatga ttggcgaaga aacgaaagcg cagattctgg aaagagaagg     5940

tcgcctgccg gatgccgtta tcgcctgtgt tggcggtggt tcgaatgcca tcggtatgtt     6000

tgcagatttc atcaacgaaa ccgacgtcgg cctgattggt gtggagcctg gcggccacgg     6060

tatcgaaact ggcgagcacg gcgcaccgtt aaaacatggt cgcgtgggca tctatttcgg     6120

tatgaaagcg ccgatgatgc aaaccgaaga cgggcaaatt gaagagtctt actccatttc     6180

tgccgggctg gatttcccgt ccgtcggccc gcaacatgcg tatctcaaca gcactggacg     6240

cgctgattac gtgtctatta ccgacgatga agccctggaa gcctttaaaa cgctttgcct     6300

gcatgaaggg atcatcccgg cgctggaatc ctcccacgcc ctggcccatg cgctgaaaat     6360

gatgcgcgaa aatccggaaa aagagcagct actggtggtt aacctttccg gtcgcggcga     6420

taaagacatc ttcaccgttc acgatatttt gaaagcacga ggggaaatct gatggaacgc     6480

tacgaatctc tgtttgccca gttgaaggag cgcaaagaag gcgcattcgt tcctttcgtc     6540

accctcggtg atccgggcat tgagcagtcg ttgaaaatta tcgatacgct aattgaagcc     6600

ggtgctgacg cgctggagtt aggcatcccc ttctccgacc cactggcgga tggcccgacg     6660

attcaaaacg ccacactgcg tgcttttgcg gcgggagtaa ccccggcgca gtgctttgag     6720

atgctggcac tcattcgcca gaagcacccg accattccca tcggcctttt gatgtatgcc     6780

aacctggtgt ttaacaaagg cattgatgag ttttatgccg agtgcgagaa agtcggcgtc     6840

gattcggtgc tggttgccga tgtgcccgtg gaagagtccg cgcccttccg ccaggccgcg     6900

ttgcgtcata atgtcgcacc tatctttatt tgcccgccga atgccgacga tgatttgctg     6960

cgccagatag cctcttacgg tcgtggttac acctatttgc tgtcgcgagc gggcgtgacc     7020

ggcgcagaaa accgcgccgc gttacccctc aatcatctgg ttgcgaagct gaaagagtac     7080

aacgctgcgc ctccattgca gggatttggt atttccgccc cggatcaggt aaaagccgcg     7140

attgatgcag gagctgcggg cgcgatttct ggttcggcca tcgttaaaat catcgagcaa     7200

catattaatg agccagagaa aatgctggcg gcactgaaag cttttgtaca accgatgaaa     7260

gcggcgacgc gcagttaata cgcatggcat ggatgaccga tggtagtgtg gggtctcccc     7320

atgcgagagt agggaactgc caggcatcaa ataaaacgaa aggctcagtc gaaagactgg     7380

gcctttcgtt ttatctgttg tttgtcggtg aacgctctcc tgagtaggac aaatccgccg     7440

ggagcggatt tgaacgttgc gaagcaacgg cccggagggt ggcgggcagg acgcccgcca     7500

taaactgcca ggcatcaaat taagcagaag gccatcctga cggatggcct ttttgcgtgg     7560

ccagtgccaa gcttgcatgc gtgc                                            7584


<210> 48
<211> 623
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Tet repressor

<400> 48
taagacccac tttcacattt aagttgtttt tctaatccgc atatgatcaa ttcaaggccg       60

aataagaagg ctggctctgc accttggtga tcaaataatt cgatagcttg tcgtaataat      120

ggcggcatac tatcagtagt aggtgtttcc ctttcttctt tagcgacttg atgctcttga      180

tcttccaata cgcaacctaa agtaaaatgc cccacagcgc tgagtgcata taatgcattc      240

tctagtgaaa aaccttgttg gcataaaaag gctaattgat tttcgagagt ttcatactgt      300

ttttctgtag gccgtgtacc taaatgtact tttgctccat cgcgatgact tagtaaagca      360

catctaaaac ttttagcgtt attacgtaaa aaatcttgcc agctttcccc ttctaaaggg      420

caaaagtgag tatggtgcct atctaacatc tcaatggcta aggcgtcgag caaagcccgc      480

ttatttttta catgccaata caatgtaggc tgctctacac ctagcttctg ggcgagttta      540

cgggttgtta aaccttcgat tccgacctca ttaagcagct ctaatgcgct gttaatcact      600

ttacttttat ctaatctaga cat                                              623


<210> 49
<211> 124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> tetR/tetA promoters and RBS and leader region

<400> 49
cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta       60

tcagtgatag agaaaagtga actctagaaa taattttgtt taactttaag aaggagatat      120

acat                                                                   124


<210> 50
<211> 1562
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> trpE

<400> 50
atgcaaacac aaaaaccgac tctcgaactg ctaacctgcg aaggcgctta tcgcgacaac       60

ccgactgcgc tttttcacca gttgtgtggg gatcgtccgg caacgctgct gctggaatcc      120

gcagatatcg acagcaaaga tgatttaaaa agcctgctgc tggtagacag tgcgctgcgc      180

attacagcat taagtgacac tgtcacaatc caggcgcttt ccggcaatgg agaagccctg      240

ttgacactac tggataacgc cttgcctgcg ggtgtggaaa atgaacaatc accaaactgc      300

cgcgtactgc gcttcccgcc tgtcagtcca ctgctggatg aagacgcccg cttatgctcc      360

ctttcggttt ttgacgcttt ccgcttatta cagaatctgt tgaatgtacc gaaggaagaa      420

cgagaagcaa tgttcttcgg cggcctgttc tcttatgacc ttgtggcggg atttgaaaat      480

ttaccgcaac tgtcagcgga aaatagctgc cctgatttct gtttttatct cgctgaaacg      540

ctgatggtga ttgaccatca gaaaaaaagc actcgtattc aggccagcct gtttgctccg      600

aatgaagaag aaaaacaacg tctcactgct cgcctgaacg aactacgtca gcaactgacc      660

gaagccgcgc cgccgctgcc ggtggtttcc gtgccgcata tgcgttgtga atgtaaccag      720

agcgatgaag agttcggtgg tgtagtgcgt ttgttgcaaa aagcgattcg cgccggagaa      780

attttccagg tggtgccatc tcgccgtttc tctctgccct gcccgtcacc gctggcagcc      840

tattacgtgc tgaaaaagag taatcccagc ccgtacatgt tttttatgca ggataatgat      900

ttcaccctgt ttggcgcgtc gccggaaagt tcgctcaagt atgacgccac cagccgccag      960

attgagattt acccgattgc cggaacacgt ccacgcggtc gtcgtgccga tggttcgctg     1020

gacagagacc tcgacagccg catcgaactg gagatgcgta ccgatcataa agagctttct     1080

gaacatctga tgctggtgga tctcgcccgt aatgacctgg cacgcatttg cacacccggc     1140

agccgctacg tcgccgatct caccaaagtt gaccgttact cttacgtgat gcacctagtc     1200

tcccgcgttg ttggtgagct gcgccacgat ctcgacgccc tgcacgctta ccgcgcctgt     1260

atgaatatgg ggacgttaag cggtgcaccg aaagtacgcg ctatgcagtt aattgccgaa     1320

gcagaaggtc gtcgacgcgg cagctacggc ggcgcggtag gttattttac cgcgcatggc     1380

gatctcgaca cctgcattgt gatccgctcg gcgctggtgg aaaacggtat cgccaccgtg     1440

caagccggtg ctggcgtagt ccttgattct gttccgcagt cggaagccga cgaaactcgt     1500

aataaagccc gcgctgtact gcgcgctatt gccaccgcgc atcatgcaca ggagacgttc     1560

ta                                                                    1562


<210> 51
<211> 1596
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> trpD

<400> 51
atggctgaca ttctgctgct cgataatatc gactctttta cgtacaacct ggcagatcag       60

ttgcgcagca atggtcataa cgtggtgatt taccgcaacc atattccggc gcagacctta      120

attgaacgcc tggcgacgat gagcaatccg gtgctgatgc tttctcctgg ccccggtgtg      180

ccgagcgaag ccggttgtat gccggaactc ctcacccgct tgcgtggcaa gctgccaatt      240

attggcattt gcctcggaca tcaggcgatt gtcgaagctt acgggggcta tgtcggtcag      300

gcgggcgaaa ttcttcacgg taaagcgtcg agcattgaac atgacggtca ggcgatgttt      360

gccggattaa caaacccgct gccagtggcg cgttatcact cgctggttgg cagtaacatt      420

ccggccggtt taaccatcaa cgcccatttt aatggcatgg tgatggcggt gcgtcacgat      480

gcagatcgcg tttgtggatt ccagttccat ccggaatcca ttcttactac ccagggcgct      540

cgcctgctgg aacaaacgct ggcctgggcg cagcagaaac tagagccaac caacacgctg      600

caaccgattc tggaaaaact gtatcaggca cagacgctta gccaacaaga aagccaccag      660

ctgttttcag cggtggtacg tggcgagctg aagccggaac aactggcggc ggcgctggtg      720

agcatgaaaa ttcgcggtga acacccgaac gagatcgccg gggcagcaac cgcgctactg      780

gaaaacgccg cgccattccc gcgcccggat tatctgtttg ccgatatcgt cggtactggc      840

ggtgacggca gcaacagcat caatatttct accgccagtg cgtttgtcgc cgcggcctgc      900

gggctgaaag tggcgaaaca cggcaaccgt agcgtctcca gtaaatccgg ctcgtcggat      960

ctgctggcgg cgttcggtat taatcttgat atgaacgccg ataaatcgcg ccaggcgctg     1020

gatgagttag gcgtctgttt cctctttgcg ccgaagtatc acaccggatt ccgccatgcg     1080

atgccggttc gccagcaact gaaaacccgc actctgttca acgtgctggg accattgatt     1140

aacccggcgc atccgccgct ggcgctaatt ggtgtttata gtccggaact ggtgctgccg     1200

attgccgaaa ccttgcgcgt gctggggtat caacgcgcgg cagtggtgca cagcggcggg     1260

atggatgaag tttcattaca cgcgccgaca atcgttgccg aactacatga cggcgaaatt     1320

aagagctatc aattgaccgc tgaagatttt ggcctgacac cctaccacca ggagcaattg     1380

gcaggcggaa caccggaaga aaaccgtgac attttaacac gcttgttaca aggtaaaggc     1440

gacgccgccc atgaagcagc cgtcgcggcg aatgtcgcca tgttaatgcg cctgcatggc     1500

catgaagatc tgcaagccaa tgcgcaaacc gttcttgagg tactgcgcag tggttccgct     1560

tacgacagag tcaccgcact ggcggcacga gggtaa                               1596


<210> 52
<211> 1359
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> trpC

<400> 52
atgcaaaccg ttttagcgaa aatcgtcgca gacaaggcga tttgggtaga aacccgcaaa       60

gagcagcaac cgctggccag ttttcagaat gaggttcagc cgagcacgcg acatttttat      120

gatgcacttc agggcgcacg cacggcgttt attctggagt gtaaaaaagc gtcgccgtca      180

aaaggcgtga tccgtgatga tttcgatccg gcacgcattg ccgccattta taaacattac      240

gcttcggcaa tttcagtgct gactgatgag aaatattttc aggggagctt tgatttcctc      300

cccatcgtca gccaaatcgc cccgcagccg attttatgta aagacttcat tatcgatcct      360

taccagatct atctggcgcg ctattaccag gccgatgcct gcttattaat gctttcagta      420

ctggatgacg aacaatatcg ccagcttgca gccgtcgccc acagtctgga gatgggtgtg      480

ctgaccgaag tcagtaatga agaggaactg gagcgcgcca ttgcattggg ggcaaaggtc      540

gttggcatca acaaccgcga tctgcgcgat ttgtcgattg atctcaaccg tacccgcgag      600

cttgcgccga aactggggca caacgtgacg gtaatcagcg aatccggcat caatacttac      660

gctcaggtgc gcgagttaag ccacttcgct aacggctttc tgattggttc ggcgttgatg      720

gcccatgacg atttgaacgc cgccgtgcgt cgggtgttgc tgggtgagaa taaagtatgt      780

ggcctgacac gtgggcaaga tgctaaagca gcttatgacg cgggcgcgat ttacggtggg      840

ttgatttttg ttgcgacatc accgcgttgc gtcaacgttg aacaggcgca ggaagtgatg      900

gctgcagcac cgttgcagta tgttggcgtg ttccgcaatc acgatattgc cgatgtggcg      960

gacaaagcta aggtgttatc gctggcggca gtgcaactgc atggtaatga agatcagctg     1020

tatatcgaca atctgcgtga ggctctgcca gcacacgtcg ccatctggaa ggctttaagt     1080

gtcggtgaaa ctcttcccgc gcgcgatttt cagcacatcg ataaatatgt attcgacaac     1140

ggtcagggcg ggagcggaca acgtttcgac tggtcactat taaatggtca atcgcttggc     1200

aacgttctgc tggcgggggg cttaggcgca gataactgcg tggaagcggc acaaaccggc     1260

tgcgccgggc ttgattttaa ttctgctgta gagtcgcaac cgggtatcaa agacgcacgt     1320

cttttggcct cggttttcca gacgctgcgc gcatattaa                            1359


<210> 53
<211> 1194
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> trpB

<400> 53
atgacaacat tacttaaccc ctattttggt gagtttggcg gcatgtacgt gccacaaatc       60

ctgatgcctg ctctgcgcca gctggaagaa gcttttgtca gcgcgcaaaa agatcctgaa      120

tttcaggctc agttcaacga cctgctgaaa aactatgccg ggcgtccaac cgcgctgacc      180

aaatgccaga acattacagc cgggacgaac accacgctgt atctgaagcg cgaagatttg      240

ctgcacggcg gcgcgcataa aactaaccag gtgctcggtc aggctttact ggcgaagcgg      300

atgggtaaaa ctgaaattat tgccgaaacc ggtgccggtc agcatggcgt ggcgtcggcc      360

cttgccagcg ccctgctcgg cctgaaatgc cgaatttata tgggtgccaa agacgttgaa      420

cgccagtcgc ccaacgtttt ccggatgcgc ttaatgggtg cggaagtgat cccggtacat      480

agcggttccg cgaccctgaa agatgcctgt aatgaggcgc tacgcgactg gtccggcagt      540

tatgaaaccg cgcactatat gctgggtacc gcagctggcc cgcatcctta cccgaccatt      600

gtgcgtgagt ttcagcggat gattggcgaa gaaacgaaag cgcagattct ggaaagagaa      660

ggtcgcctgc cggatgccgt tatcgcctgt gttggcggtg gttcgaatgc catcggtatg      720

tttgcagatt tcatcaacga aaccgacgtc ggcctgattg gtgtggagcc tggcggccac      780

ggtatcgaaa ctggcgagca cggcgcaccg ttaaaacatg gtcgcgtggg catctatttc      840

ggtatgaaag cgccgatgat gcaaaccgaa gacgggcaaa ttgaagagtc ttactccatt      900

tctgccgggc tggatttccc gtccgtcggc ccgcaacatg cgtatctcaa cagcactgga      960

cgcgctgatt acgtgtctat taccgacgat gaagccctgg aagcctttaa aacgctttgc     1020

ctgcatgaag ggatcatccc ggcgctggaa tcctcccacg ccctggccca tgcgctgaaa     1080

atgatgcgcg aaaatccgga aaaagagcag ctactggtgg ttaacctttc cggtcgcggc     1140

gataaagaca tcttcaccgt tcacgatatt ttgaaagcac gaggggaaat ctga           1194


<210> 54
<211> 807
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> trpA

<400> 54
atggaacgct acgaatctct gtttgcccag ttgaaggagc gcaaagaagg cgcattcgtt       60

cctttcgtca ccctcggtga tccgggcatt gagcagtcgt tgaaaattat cgatacgcta      120

attgaagccg gtgctgacgc gctggagtta ggcatcccct tctccgaccc actggcggat      180

ggcccgacga ttcaaaacgc cacactgcgt gcttttgcgg cgggagtaac cccggcgcag      240

tgctttgaga tgctggcact cattcgccag aagcacccga ccattcccat cggccttttg      300

atgtatgcca acctggtgtt taacaaaggc attgatgagt tttatgccga gtgcgagaaa      360

gtcggcgtcg attcggtgct ggttgccgat gtgcccgtgg aagagtccgc gcccttccgc      420

caggccgcgt tgcgtcataa tgtcgcacct atctttattt gcccgccgaa tgccgacgat      480

gatttgctgc gccagatagc ctcttacggt cgtggttaca cctatttgct gtcgcgagcg      540

ggcgtgaccg gcgcagaaaa ccgcgccgcg ttacccctca atcatctggt tgcgaagctg      600

aaagagtaca acgctgcgcc tccattgcag ggatttggta tttccgcccc ggatcaggta      660

aaagccgcga ttgatgcagg agctgcgggc gcgatttctg gttcggccat cgttaaaatc      720

atcgagcaac atattaatga gccagagaaa atgctggcgg cactgaaagc ttttgtacaa      780

ccgatgaaag cggcgacgcg cagttaa                                          807


<210> 55
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TrpE

<400> 55
Met Gln Thr Gln Lys Pro Thr Leu Glu Leu Leu Thr Cys Glu Gly Ala 
1               5                   10                  15      


Tyr Arg Asp Asn Pro Thr Ala Leu Phe His Gln Leu Cys Gly Asp Arg 
            20                  25                  30          


Pro Ala Thr Leu Leu Leu Glu Ser Ala Asp Ile Asp Ser Lys Asp Asp 
        35                  40                  45              


Leu Lys Ser Leu Leu Leu Val Asp Ser Ala Leu Arg Ile Thr Ala Leu 
    50                  55                  60                  


Ser Asp Thr Val Thr Ile Gln Ala Leu Ser Gly Asn Gly Glu Ala Leu 
65                  70                  75                  80  


Leu Thr Leu Leu Asp Asn Ala Leu Pro Ala Gly Val Glu Asn Glu Gln 
                85                  90                  95      


Ser Pro Asn Cys Arg Val Leu Arg Phe Pro Pro Val Ser Pro Leu Leu 
            100                 105                 110         


Asp Glu Asp Ala Arg Leu Cys Ser Leu Ser Val Phe Asp Ala Phe Arg 
        115                 120                 125             


Leu Leu Gln Asn Leu Leu Asn Val Pro Lys Glu Glu Arg Glu Ala Met 
    130                 135                 140                 


Phe Phe Gly Gly Leu Phe Ser Tyr Asp Leu Val Ala Gly Phe Glu Asn 
145                 150                 155                 160 


Leu Pro Gln Leu Ser Ala Glu Asn Ser Cys Pro Asp Phe Cys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Thr Leu Met Val Ile Asp His Gln Lys Lys Ser Thr Arg 
            180                 185                 190         


Ile Gln Ala Ser Leu Phe Ala Pro Asn Glu Glu Glu Lys Gln Arg Leu 
        195                 200                 205             


Thr Ala Arg Leu Asn Glu Leu Arg Gln Gln Leu Thr Glu Ala Ala Pro 
    210                 215                 220                 


Pro Leu Pro Val Val Ser Val Pro His Met Arg Cys Glu Cys Asn Gln 
225                 230                 235                 240 


Ser Asp Glu Glu Phe Gly Gly Val Val Arg Leu Leu Gln Lys Ala Ile 
                245                 250                 255     


Arg Ala Gly Glu Ile Phe Gln Val Val Pro Ser Arg Arg Phe Ser Leu 
            260                 265                 270         


Pro Cys Pro Ser Pro Leu Ala Ala Tyr Tyr Val Leu Lys Lys Ser Asn 
        275                 280                 285             


Pro Ser Pro Tyr Met Phe Phe Met Gln Asp Asn Asp Phe Thr Leu Phe 
    290                 295                 300                 


Gly Ala Ser Pro Glu Ser Ser Leu Lys Tyr Asp Ala Thr Ser Arg Gln 
305                 310                 315                 320 


Ile Glu Ile Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Arg Arg Ala 
                325                 330                 335     


Asp Gly Ser Leu Asp Arg Asp Leu Asp Ser Arg Ile Glu Leu Glu Met 
            340                 345                 350         


Arg Thr Asp His Lys Glu Leu Ser Glu His Leu Met Leu Val Asp Leu 
        355                 360                 365             


Ala Arg Asn Asp Leu Ala Arg Ile Cys Thr Pro Gly Ser Arg Tyr Val 
    370                 375                 380                 


Ala Asp Leu Thr Lys Val Asp Arg Tyr Ser Tyr Val Met His Leu Val 
385                 390                 395                 400 


Ser Arg Val Val Gly Glu Leu Arg His Asp Leu Asp Ala Leu His Ala 
                405                 410                 415     


Tyr Arg Ala Cys Met Asn Met Gly Thr Leu Ser Gly Ala Pro Lys Val 
            420                 425                 430         


Arg Ala Met Gln Leu Ile Ala Glu Ala Glu Gly Arg Arg Arg Gly Ser 
        435                 440                 445             


Tyr Gly Gly Ala Val Gly Tyr Phe Thr Ala His Gly Asp Leu Asp Thr 
    450                 455                 460                 


Cys Ile Val Ile Arg Ser Ala Leu Val Glu Asn Gly Ile Ala Thr Val 
465                 470                 475                 480 


Gln Ala Gly Ala Gly Val Val Leu Asp Ser Val Pro Gln Ser Glu Ala 
                485                 490                 495     


Asp Glu Thr Arg Asn Lys Ala Arg Ala Val Leu Arg Ala Ile Ala Thr 
            500                 505                 510         


Ala His His Ala Gln Glu Thr Phe 
        515                 520 


<210> 56
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TrpD

<400> 56
Met Ala Asp Ile Leu Leu Leu Asp Asn Ile Asp Ser Phe Thr Tyr Asn 
1               5                   10                  15      


Leu Ala Asp Gln Leu Arg Ser Asn Gly His Asn Val Val Ile Tyr Arg 
            20                  25                  30          


Asn His Ile Pro Ala Gln Thr Leu Ile Glu Arg Leu Ala Thr Met Ser 
        35                  40                  45              


Asn Pro Val Leu Met Leu Ser Pro Gly Pro Gly Val Pro Ser Glu Ala 
    50                  55                  60                  


Gly Cys Met Pro Glu Leu Leu Thr Arg Leu Arg Gly Lys Leu Pro Ile 
65                  70                  75                  80  


Ile Gly Ile Cys Leu Gly His Gln Ala Ile Val Glu Ala Tyr Gly Gly 
                85                  90                  95      


Tyr Val Gly Gln Ala Gly Glu Ile Leu His Gly Lys Ala Ser Ser Ile 
            100                 105                 110         


Glu His Asp Gly Gln Ala Met Phe Ala Gly Leu Thr Asn Pro Leu Pro 
        115                 120                 125             


Val Ala Arg Tyr His Ser Leu Val Gly Ser Asn Ile Pro Ala Gly Leu 
    130                 135                 140                 


Thr Ile Asn Ala His Phe Asn Gly Met Val Met Ala Val Arg His Asp 
145                 150                 155                 160 


Ala Asp Arg Val Cys Gly Phe Gln Phe His Pro Glu Ser Ile Leu Thr 
                165                 170                 175     


Thr Gln Gly Ala Arg Leu Leu Glu Gln Thr Leu Ala Trp Ala Gln Gln 
            180                 185                 190         


Lys Leu Glu Pro Thr Asn Thr Leu Gln Pro Ile Leu Glu Lys Leu Tyr 
        195                 200                 205             


Gln Ala Gln Thr Leu Ser Gln Gln Glu Ser His Gln Leu Phe Ser Ala 
    210                 215                 220                 


Val Val Arg Gly Glu Leu Lys Pro Glu Gln Leu Ala Ala Ala Leu Val 
225                 230                 235                 240 


Ser Met Lys Ile Arg Gly Glu His Pro Asn Glu Ile Ala Gly Ala Ala 
                245                 250                 255     


Thr Ala Leu Leu Glu Asn Ala Ala Pro Phe Pro Arg Pro Asp Tyr Leu 
            260                 265                 270         


Phe Ala Asp Ile Val Gly Thr Gly Gly Asp Gly Ser Asn Ser Ile Asn 
        275                 280                 285             


Ile Ser Thr Ala Ser Ala Phe Val Ala Ala Ala Cys Gly Leu Lys Val 
    290                 295                 300                 


Ala Lys His Gly Asn Arg Ser Val Ser Ser Lys Ser Gly Ser Ser Asp 
305                 310                 315                 320 


Leu Leu Ala Ala Phe Gly Ile Asn Leu Asp Met Asn Ala Asp Lys Ser 
                325                 330                 335     


Arg Gln Ala Leu Asp Glu Leu Gly Val Cys Phe Leu Phe Ala Pro Lys 
            340                 345                 350         


Tyr His Thr Gly Phe Arg His Ala Met Pro Val Arg Gln Gln Leu Lys 
        355                 360                 365             


Thr Arg Thr Leu Phe Asn Val Leu Gly Pro Leu Ile Asn Pro Ala His 
    370                 375                 380                 


Pro Pro Leu Ala Leu Ile Gly Val Tyr Ser Pro Glu Leu Val Leu Pro 
385                 390                 395                 400 


Ile Ala Glu Thr Leu Arg Val Leu Gly Tyr Gln Arg Ala Ala Val Val 
                405                 410                 415     


His Ser Gly Gly Met Asp Glu Val Ser Leu His Ala Pro Thr Ile Val 
            420                 425                 430         


Ala Glu Leu His Asp Gly Glu Ile Lys Ser Tyr Gln Leu Thr Ala Glu 
        435                 440                 445             


Asp Phe Gly Leu Thr Pro Tyr His Gln Glu Gln Leu Ala Gly Gly Thr 
    450                 455                 460                 


Pro Glu Glu Asn Arg Asp Ile Leu Thr Arg Leu Leu Gln Gly Lys Gly 
465                 470                 475                 480 


Asp Ala Ala His Glu Ala Ala Val Ala Ala Asn Val Ala Met Leu Met 
                485                 490                 495     


Arg Leu His Gly His Glu Asp Leu Gln Ala Asn Ala Gln Thr Val Leu 
            500                 505                 510         


Glu Val Leu Arg Ser Gly Ser Ala Tyr Asp Arg Val Thr Ala Leu Ala 
        515                 520                 525             


Ala Arg Gly 
    530     


<210> 57
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TrpC

<400> 57
Met Gln Thr Val Leu Ala Lys Ile Val Ala Asp Lys Ala Ile Trp Val 
1               5                   10                  15      


Glu Thr Arg Lys Glu Gln Gln Pro Leu Ala Ser Phe Gln Asn Glu Val 
            20                  25                  30          


Gln Pro Ser Thr Arg His Phe Tyr Asp Ala Leu Gln Gly Ala Arg Thr 
        35                  40                  45              


Ala Phe Ile Leu Glu Cys Lys Lys Ala Ser Pro Ser Lys Gly Val Ile 
    50                  55                  60                  


Arg Asp Asp Phe Asp Pro Ala Arg Ile Ala Ala Ile Tyr Lys His Tyr 
65                  70                  75                  80  


Ala Ser Ala Ile Ser Val Leu Thr Asp Glu Lys Tyr Phe Gln Gly Ser 
                85                  90                  95      


Phe Asp Phe Leu Pro Ile Val Ser Gln Ile Ala Pro Gln Pro Ile Leu 
            100                 105                 110         


Cys Lys Asp Phe Ile Ile Asp Pro Tyr Gln Ile Tyr Leu Ala Arg Tyr 
        115                 120                 125             


Tyr Gln Ala Asp Ala Cys Leu Leu Met Leu Ser Val Leu Asp Asp Glu 
    130                 135                 140                 


Gln Tyr Arg Gln Leu Ala Ala Val Ala His Ser Leu Glu Met Gly Val 
145                 150                 155                 160 


Leu Thr Glu Val Ser Asn Glu Glu Glu Leu Glu Arg Ala Ile Ala Leu 
                165                 170                 175     


Gly Ala Lys Val Val Gly Ile Asn Asn Arg Asp Leu Arg Asp Leu Ser 
            180                 185                 190         


Ile Asp Leu Asn Arg Thr Arg Glu Leu Ala Pro Lys Leu Gly His Asn 
        195                 200                 205             


Val Thr Val Ile Ser Glu Ser Gly Ile Asn Thr Tyr Ala Gln Val Arg 
    210                 215                 220                 


Glu Leu Ser His Phe Ala Asn Gly Phe Leu Ile Gly Ser Ala Leu Met 
225                 230                 235                 240 


Ala His Asp Asp Leu Asn Ala Ala Val Arg Arg Val Leu Leu Gly Glu 
                245                 250                 255     


Asn Lys Val Cys Gly Leu Thr Arg Gly Gln Asp Ala Lys Ala Ala Tyr 
            260                 265                 270         


Asp Ala Gly Ala Ile Tyr Gly Gly Leu Ile Phe Val Ala Thr Ser Pro 
        275                 280                 285             


Arg Cys Val Asn Val Glu Gln Ala Gln Glu Val Met Ala Ala Ala Pro 
    290                 295                 300                 


Leu Gln Tyr Val Gly Val Phe Arg Asn His Asp Ile Ala Asp Val Ala 
305                 310                 315                 320 


Asp Lys Ala Lys Val Leu Ser Leu Ala Ala Val Gln Leu His Gly Asn 
                325                 330                 335     


Glu Asp Gln Leu Tyr Ile Asp Asn Leu Arg Glu Ala Leu Pro Ala His 
            340                 345                 350         


Val Ala Ile Trp Lys Ala Leu Ser Val Gly Glu Thr Leu Pro Ala Arg 
        355                 360                 365             


Asp Phe Gln His Ile Asp Lys Tyr Val Phe Asp Asn Gly Gln Gly Gly 
    370                 375                 380                 


Ser Gly Gln Arg Phe Asp Trp Ser Leu Leu Asn Gly Gln Ser Leu Gly 
385                 390                 395                 400 


Asn Val Leu Leu Ala Gly Gly Leu Gly Ala Asp Asn Cys Val Glu Ala 
                405                 410                 415     


Ala Gln Thr Gly Cys Ala Gly Leu Asp Phe Asn Ser Ala Val Glu Ser 
            420                 425                 430         


Gln Pro Gly Ile Lys Asp Ala Arg Leu Leu Ala Ser Val Phe Gln Thr 
        435                 440                 445             


Leu Arg Ala Tyr 
    450         


<210> 58
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TrpB

<400> 58
Met Thr Thr Leu Leu Asn Pro Tyr Phe Gly Glu Phe Gly Gly Met Tyr 
1               5                   10                  15      


Val Pro Gln Ile Leu Met Pro Ala Leu Arg Gln Leu Glu Glu Ala Phe 
            20                  25                  30          


Val Ser Ala Gln Lys Asp Pro Glu Phe Gln Ala Gln Phe Asn Asp Leu 
        35                  40                  45              


Leu Lys Asn Tyr Ala Gly Arg Pro Thr Ala Leu Thr Lys Cys Gln Asn 
    50                  55                  60                  


Ile Thr Ala Gly Thr Asn Thr Thr Leu Tyr Leu Lys Arg Glu Asp Leu 
65                  70                  75                  80  


Leu His Gly Gly Ala His Lys Thr Asn Gln Val Leu Gly Gln Ala Leu 
                85                  90                  95      


Leu Ala Lys Arg Met Gly Lys Thr Glu Ile Ile Ala Glu Thr Gly Ala 
            100                 105                 110         


Gly Gln His Gly Val Ala Ser Ala Leu Ala Ser Ala Leu Leu Gly Leu 
        115                 120                 125             


Lys Cys Arg Ile Tyr Met Gly Ala Lys Asp Val Glu Arg Gln Ser Pro 
    130                 135                 140                 


Asn Val Phe Arg Met Arg Leu Met Gly Ala Glu Val Ile Pro Val His 
145                 150                 155                 160 


Ser Gly Ser Ala Thr Leu Lys Asp Ala Cys Asn Glu Ala Leu Arg Asp 
                165                 170                 175     


Trp Ser Gly Ser Tyr Glu Thr Ala His Tyr Met Leu Gly Thr Ala Ala 
            180                 185                 190         


Gly Pro His Pro Tyr Pro Thr Ile Val Arg Glu Phe Gln Arg Met Ile 
        195                 200                 205             


Gly Glu Glu Thr Lys Ala Gln Ile Leu Glu Arg Glu Gly Arg Leu Pro 
    210                 215                 220                 


Asp Ala Val Ile Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met 
225                 230                 235                 240 


Phe Ala Asp Phe Ile Asn Glu Thr Asp Val Gly Leu Ile Gly Val Glu 
                245                 250                 255     


Pro Gly Gly His Gly Ile Glu Thr Gly Glu His Gly Ala Pro Leu Lys 
            260                 265                 270         


His Gly Arg Val Gly Ile Tyr Phe Gly Met Lys Ala Pro Met Met Gln 
        275                 280                 285             


Thr Glu Asp Gly Gln Ile Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu 
    290                 295                 300                 


Asp Phe Pro Ser Val Gly Pro Gln His Ala Tyr Leu Asn Ser Thr Gly 
305                 310                 315                 320 


Arg Ala Asp Tyr Val Ser Ile Thr Asp Asp Glu Ala Leu Glu Ala Phe 
                325                 330                 335     


Lys Thr Leu Cys Leu His Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser 
            340                 345                 350         


His Ala Leu Ala His Ala Leu Lys Met Met Arg Glu Asn Pro Glu Lys 
        355                 360                 365             


Glu Gln Leu Leu Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Ile 
    370                 375                 380                 


Phe Thr Val His Asp Ile Leu Lys Ala Arg Gly Glu Ile 
385                 390                 395         


<210> 59
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TrpA

<400> 59
Met Glu Arg Tyr Glu Ser Leu Phe Ala Gln Leu Lys Glu Arg Lys Glu 
1               5                   10                  15      


Gly Ala Phe Val Pro Phe Val Thr Leu Gly Asp Pro Gly Ile Glu Gln 
            20                  25                  30          


Ser Leu Lys Ile Ile Asp Thr Leu Ile Glu Ala Gly Ala Asp Ala Leu 
        35                  40                  45              


Glu Leu Gly Ile Pro Phe Ser Asp Pro Leu Ala Asp Gly Pro Thr Ile 
    50                  55                  60                  


Gln Asn Ala Thr Leu Arg Ala Phe Ala Ala Gly Val Thr Pro Ala Gln 
65                  70                  75                  80  


Cys Phe Glu Met Leu Ala Leu Ile Arg Gln Lys His Pro Thr Ile Pro 
                85                  90                  95      


Ile Gly Leu Leu Met Tyr Ala Asn Leu Val Phe Asn Lys Gly Ile Asp 
            100                 105                 110         


Glu Phe Tyr Ala Glu Cys Glu Lys Val Gly Val Asp Ser Val Leu Val 
        115                 120                 125             


Ala Asp Val Pro Val Glu Glu Ser Ala Pro Phe Arg Gln Ala Ala Leu 
    130                 135                 140                 


Arg His Asn Val Ala Pro Ile Phe Ile Cys Pro Pro Asn Ala Asp Asp 
145                 150                 155                 160 


Asp Leu Leu Arg Gln Ile Ala Ser Tyr Gly Arg Gly Tyr Thr Tyr Leu 
                165                 170                 175     


Leu Ser Arg Ala Gly Val Thr Gly Ala Glu Asn Arg Ala Ala Leu Pro 
            180                 185                 190         


Leu Asn His Leu Val Ala Lys Leu Lys Glu Tyr Asn Ala Ala Pro Pro 
        195                 200                 205             


Leu Gln Gly Phe Gly Ile Ser Ala Pro Asp Gln Val Lys Ala Ala Ile 
    210                 215                 220                 


Asp Ala Gly Ala Ala Gly Ala Ile Ser Gly Ser Ala Ile Val Lys Ile 
225                 230                 235                 240 


Ile Glu Gln His Ile Asn Glu Pro Glu Lys Met Leu Ala Ala Leu Lys 
                245                 250                 255     


Ala Phe Val Gln Pro Met Lys Ala Ala Thr Arg Ser 
            260                 265             


<210> 60
<211> 350
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> AroGfbr: feedback resistant 
      2-dehydro-3-deoxyphosphoheptonate aldolase from E. coli

<400> 60
Met Asn Tyr Gln Asn Asp Asp Leu Arg Ile Lys Glu Ile Lys Glu Leu 
1               5                   10                  15      


Leu Pro Pro Val Ala Leu Leu Glu Lys Phe Pro Ala Thr Glu Asn Ala 
            20                  25                  30          


Ala Asn Thr Val Ala His Ala Arg Lys Ala Ile His Lys Ile Leu Lys 
        35                  40                  45              


Gly Asn Asp Asp Arg Leu Leu Val Val Ile Gly Pro Cys Ser Ile His 
    50                  55                  60                  


Asp Pro Val Ala Ala Lys Glu Tyr Ala Thr Arg Leu Leu Thr Leu Arg 
65                  70                  75                  80  


Glu Glu Leu Gln Asp Glu Leu Glu Ile Val Met Arg Val Tyr Phe Glu 
                85                  90                  95      


Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp Pro His 
            100                 105                 110         


Met Asp Asn Ser Phe Gln Ile Asn Asp Gly Leu Arg Ile Ala Arg Lys 
        115                 120                 125             


Leu Leu Leu Asp Ile Asn Asp Ser Gly Leu Pro Ala Ala Gly Glu Phe 
    130                 135                 140                 


Leu Asp Met Ile Thr Leu Gln Tyr Leu Ala Asp Leu Met Ser Trp Gly 
145                 150                 155                 160 


Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu Leu Ala 
                165                 170                 175     


Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp Gly Thr 
            180                 185                 190         


Ile Lys Val Ala Ile Asp Ala Ile Asn Ala Ala Gly Ala Pro His Cys 
        195                 200                 205             


Phe Leu Ser Val Thr Lys Trp Gly His Ser Ala Ile Val Asn Thr Ser 
    210                 215                 220                 


Gly Asn Gly Asp Cys His Ile Ile Leu Arg Gly Gly Lys Glu Pro Asn 
225                 230                 235                 240 


Tyr Ser Ala Lys His Val Ala Glu Val Lys Glu Gly Leu Asn Lys Ala 
                245                 250                 255     


Gly Leu Pro Ala Gln Val Met Ile Asp Phe Ser His Ala Asn Ser Ser 
            260                 265                 270         


Lys Gln Phe Lys Lys Gln Met Asp Val Cys Thr Asp Val Cys Gln Gln 
        275                 280                 285             


Ile Ala Gly Gly Glu Lys Ala Ile Ile Gly Val Met Val Glu Ser His 
    290                 295                 300                 


Leu Val Glu Gly Asn Gln Ser Leu Glu Ser Gly Glu Pro Leu Ala Tyr 
305                 310                 315                 320 


Gly Lys Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Asp Thr Asp Ala 
                325                 330                 335     


Leu Leu Arg Gln Leu Ala Ser Ala Val Lys Ala Arg Arg Gly 
            340                 345                 350 


<210> 61
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TrpEfbr: feedback resistant anthranilate synthase
      component I from E. coli

<400> 61
Met Gln Thr Gln Lys Pro Thr Leu Glu Leu Leu Thr Cys Glu Gly Ala 
1               5                   10                  15      


Tyr Arg Asp Asn Pro Thr Ala Leu Phe His Gln Leu Cys Gly Asp Arg 
            20                  25                  30          


Pro Ala Thr Leu Leu Leu Glu Phe Ala Asp Ile Asp Ser Lys Asp Asp 
        35                  40                  45              


Leu Lys Ser Leu Leu Leu Val Asp Ser Ala Leu Arg Ile Thr Ala Leu 
    50                  55                  60                  


Ser Asp Thr Val Thr Ile Gln Ala Leu Ser Gly Asn Gly Glu Ala Leu 
65                  70                  75                  80  


Leu Thr Leu Leu Asp Asn Ala Leu Pro Ala Gly Val Glu Asn Glu Gln 
                85                  90                  95      


Ser Pro Asn Cys Arg Val Leu Arg Phe Pro Pro Val Ser Pro Leu Leu 
            100                 105                 110         


Asp Glu Asp Ala Arg Leu Cys Ser Leu Ser Val Phe Asp Ala Phe Arg 
        115                 120                 125             


Leu Leu Gln Asn Leu Leu Asn Val Pro Lys Glu Glu Arg Glu Ala Met 
    130                 135                 140                 


Phe Phe Gly Gly Leu Phe Ser Tyr Asp Leu Val Ala Gly Phe Glu Asn 
145                 150                 155                 160 


Leu Pro Gln Leu Ser Ala Glu Asn Ser Cys Pro Asp Phe Cys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Thr Leu Met Val Ile Asp His Gln Lys Lys Ser Thr Arg 
            180                 185                 190         


Ile Gln Ala Ser Leu Phe Ala Pro Asn Glu Glu Glu Lys Gln Arg Leu 
        195                 200                 205             


Thr Ala Arg Leu Asn Glu Leu Arg Gln Gln Leu Thr Glu Ala Ala Pro 
    210                 215                 220                 


Pro Leu Pro Val Val Ser Val Pro His Met Arg Cys Glu Cys Asn Gln 
225                 230                 235                 240 


Ser Asp Glu Glu Phe Gly Gly Val Val Arg Leu Leu Gln Lys Ala Ile 
                245                 250                 255     


Arg Ala Gly Glu Ile Phe Gln Val Val Pro Ser Arg Arg Phe Ser Leu 
            260                 265                 270         


Pro Cys Pro Ser Pro Leu Ala Ala Tyr Tyr Val Leu Lys Lys Ser Asn 
        275                 280                 285             


Pro Ser Pro Tyr Met Phe Phe Met Gln Asp Asn Asp Phe Thr Leu Phe 
    290                 295                 300                 


Gly Ala Ser Pro Glu Ser Ser Leu Lys Tyr Asp Ala Thr Ser Arg Gln 
305                 310                 315                 320 


Ile Glu Ile Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Arg Arg Ala 
                325                 330                 335     


Asp Gly Ser Leu Asp Arg Asp Leu Asp Ser Arg Ile Glu Leu Glu Met 
            340                 345                 350         


Arg Thr Asp His Lys Glu Leu Ser Glu His Leu Met Leu Val Asp Leu 
        355                 360                 365             


Ala Arg Asn Asp Leu Ala Arg Ile Cys Thr Pro Gly Ser Arg Tyr Val 
    370                 375                 380                 


Ala Asp Leu Thr Lys Val Asp Arg Tyr Ser Tyr Val Met His Leu Val 
385                 390                 395                 400 


Ser Arg Val Val Gly Glu Leu Arg His Asp Leu Asp Ala Leu His Ala 
                405                 410                 415     


Tyr Arg Ala Cys Met Asn Met Gly Thr Leu Ser Gly Ala Pro Lys Val 
            420                 425                 430         


Arg Ala Met Gln Leu Ile Ala Glu Ala Glu Gly Arg Arg Arg Gly Ser 
        435                 440                 445             


Tyr Gly Gly Ala Val Gly Tyr Phe Thr Ala His Gly Asp Leu Asp Thr 
    450                 455                 460                 


Cys Ile Val Ile Arg Ser Ala Leu Val Glu Asn Gly Ile Ala Thr Val 
465                 470                 475                 480 


Gln Ala Gly Ala Gly Val Val Leu Asp Ser Val Pro Gln Ser Glu Ala 
                485                 490                 495     


Asp Glu Thr Arg Asn Lys Ala Arg Ala Val Leu Arg Ala Ile Ala Thr 
            500                 505                 510         


Ala His His Ala Gln Glu Thr Phe 
        515                 520 


<210> 62
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> SerA: 2-oxoglutarate reductase from E. coli Nissle

<400> 62
Met Ala Lys Val Ser Leu Glu Lys Asp Lys Ile Lys Phe Leu Leu Val 
1               5                   10                  15      


Glu Gly Val His Gln Lys Ala Leu Glu Ser Leu Arg Ala Ala Gly Tyr 
            20                  25                  30          


Thr Asn Ile Glu Phe His Lys Gly Ala Leu Asp Asp Glu Gln Leu Lys 
        35                  40                  45              


Glu Ser Ile Arg Asp Ala His Phe Ile Gly Leu Arg Ser Arg Thr His 
    50                  55                  60                  


Leu Thr Glu Asp Val Ile Asn Ala Ala Glu Lys Leu Val Ala Ile Gly 
65                  70                  75                  80  


Cys Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Ala Ala Ala Lys 
                85                  90                  95      


Arg Gly Ile Pro Val Phe Asn Ala Pro Phe Ser Asn Thr Arg Ser Val 
            100                 105                 110         


Ala Glu Leu Val Ile Gly Glu Leu Leu Leu Leu Leu Arg Gly Val Pro 
        115                 120                 125             


Glu Ala Asn Ala Lys Ala His Arg Gly Val Trp Asn Lys Leu Ala Ala 
    130                 135                 140                 


Gly Ser Phe Glu Ala Arg Gly Lys Lys Leu Gly Ile Ile Gly Tyr Gly 
145                 150                 155                 160 


His Ile Gly Thr Gln Leu Gly Ile Leu Ala Glu Ser Leu Gly Met Tyr 
                165                 170                 175     


Val Tyr Phe Tyr Asp Ile Glu Asn Lys Leu Pro Leu Gly Asn Ala Thr 
            180                 185                 190         


Gln Val Gln His Leu Ser Asp Leu Leu Asn Met Ser Asp Val Val Ser 
        195                 200                 205             


Leu His Val Pro Glu Asn Pro Ser Thr Lys Asn Met Met Gly Ala Lys 
    210                 215                 220                 


Glu Ile Ser Leu Met Lys Pro Gly Ser Leu Leu Ile Asn Ala Ser Arg 
225                 230                 235                 240 


Gly Thr Val Val Asp Ile Pro Ala Leu Cys Asp Ala Leu Ala Ser Lys 
                245                 250                 255     


His Leu Ala Gly Ala Ala Ile Asp Val Phe Pro Thr Glu Pro Ala Thr 
            260                 265                 270         


Asn Ser Asp Pro Phe Thr Ser Pro Leu Cys Glu Phe Asp Asn Val Leu 
        275                 280                 285             


Leu Thr Pro His Ile Gly Gly Ser Thr Gln Glu Ala Gln Glu Asn Ile 
    290                 295                 300                 


Gly Leu Glu Val Ala Gly Lys Leu Ile Lys Tyr Ser Asp Asn Gly Ser 
305                 310                 315                 320 


Thr Leu Ser Ala Val Asn Phe Pro Glu Val Ser Leu Pro Leu His Gly 
                325                 330                 335     


Gly Arg Arg Leu Met His Ile His Glu Asn Arg Pro Gly Val Leu Thr 
            340                 345                 350         


Ala Leu Asn Lys Ile Phe Ala Glu Gln Gly Val Asn Ile Ala Ala Gln 
        355                 360                 365             


Tyr Leu Gln Thr Ser Ala Gln Met Gly Tyr Val Val Ile Asp Ile Glu 
    370                 375                 380                 


Ala Asp Glu Asp Val Ala Glu Lys Ala Leu Gln Ala Met Lys Ala Ile 
385                 390                 395                 400 


Pro Gly Thr Ile Arg Ala Arg Leu Leu Tyr 
                405                 410 


<210> 63
<211> 410
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> SerAfbr: feedback resistant 2-oxoglutarate reductase
      from E. coli Nissle

<400> 63
Met Ala Lys Val Ser Leu Glu Lys Asp Lys Ile Lys Phe Leu Leu Val 
1               5                   10                  15      


Glu Gly Val His Gln Lys Ala Leu Glu Ser Leu Arg Ala Ala Gly Tyr 
            20                  25                  30          


Thr Asn Ile Glu Phe His Lys Gly Ala Leu Asp Asp Glu Gln Leu Lys 
        35                  40                  45              


Glu Ser Ile Arg Asp Ala His Phe Ile Gly Leu Arg Ser Arg Thr His 
    50                  55                  60                  


Leu Thr Glu Asp Val Ile Asn Ala Ala Glu Lys Leu Val Ala Ile Gly 
65                  70                  75                  80  


Cys Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Asp Ala Ala Ala Lys 
                85                  90                  95      


Arg Gly Ile Pro Val Phe Asn Ala Pro Phe Ser Asn Thr Arg Ser Val 
            100                 105                 110         


Ala Glu Leu Val Ile Gly Glu Leu Leu Leu Leu Leu Arg Gly Val Pro 
        115                 120                 125             


Glu Ala Asn Ala Lys Ala His Arg Gly Val Trp Asn Lys Leu Ala Ala 
    130                 135                 140                 


Gly Ser Phe Glu Ala Arg Gly Lys Lys Leu Gly Ile Ile Gly Tyr Gly 
145                 150                 155                 160 


His Ile Gly Thr Gln Leu Gly Ile Leu Ala Glu Ser Leu Gly Met Tyr 
                165                 170                 175     


Val Tyr Phe Tyr Asp Ile Glu Asn Lys Leu Pro Leu Gly Asn Ala Thr 
            180                 185                 190         


Gln Val Gln His Leu Ser Asp Leu Leu Asn Met Ser Asp Val Val Ser 
        195                 200                 205             


Leu His Val Pro Glu Asn Pro Ser Thr Lys Asn Met Met Gly Ala Lys 
    210                 215                 220                 


Glu Ile Ser Leu Met Lys Pro Gly Ser Leu Leu Ile Asn Ala Ser Arg 
225                 230                 235                 240 


Gly Thr Val Val Asp Ile Pro Ala Leu Cys Asp Ala Leu Ala Ser Lys 
                245                 250                 255     


His Leu Ala Gly Ala Ala Ile Asp Val Phe Pro Thr Glu Pro Ala Thr 
            260                 265                 270         


Asn Ser Asp Pro Phe Thr Ser Pro Leu Cys Glu Phe Asp Asn Val Leu 
        275                 280                 285             


Leu Thr Pro His Ile Gly Gly Ser Thr Gln Glu Ala Gln Glu Asn Ile 
    290                 295                 300                 


Gly Leu Glu Val Ala Gly Lys Leu Ile Lys Tyr Ser Asp Asn Gly Ser 
305                 310                 315                 320 


Thr Leu Ser Ala Val Asn Phe Pro Glu Val Ser Leu Pro Leu His Gly 
                325                 330                 335     


Gly Arg Arg Leu Met His Ile Ala Glu Ala Arg Pro Gly Val Leu Thr 
            340                 345                 350         


Ala Leu Asn Lys Ile Phe Ala Glu Gln Gly Val Asn Ile Ala Ala Gln 
        355                 360                 365             


Tyr Leu Gln Thr Ser Ala Gln Met Gly Tyr Val Val Ile Asp Ile Glu 
    370                 375                 380                 


Ala Asp Glu Asp Val Ala Glu Lys Ala Leu Gln Ala Met Lys Ala Ile 
385                 390                 395                 400 


Pro Gly Thr Ile Arg Ala Arg Leu Leu Tyr 
                405                 410 


<210> 64
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TnaA: tryptophanase from E. coli

<400> 64
Met Glu Asn Phe Lys His Leu Pro Glu Pro Phe Arg Ile Arg Val Ile 
1               5                   10                  15      


Glu Pro Val Lys Arg Thr Thr Arg Ala Tyr Arg Glu Glu Ala Ile Ile 
            20                  25                  30          


Lys Ser Gly Met Asn Pro Phe Leu Leu Asp Ser Glu Asp Val Phe Ile 
        35                  40                  45              


Asp Leu Leu Thr Asp Ser Gly Thr Gly Ala Val Thr Gln Ser Met Gln 
    50                  55                  60                  


Ala Ala Met Met Arg Gly Asp Glu Ala Tyr Ser Gly Ser Arg Ser Tyr 
65                  70                  75                  80  


Tyr Ala Leu Ala Glu Ser Val Lys Asn Ile Phe Gly Tyr Gln Tyr Thr 
                85                  90                  95      


Ile Pro Thr His Gln Gly Arg Gly Ala Glu Gln Ile Tyr Ile Pro Val 
            100                 105                 110         


Leu Ile Lys Lys Arg Glu Gln Glu Lys Gly Leu Asp Arg Ser Lys Met 
        115                 120                 125             


Val Ala Phe Ser Asn Tyr Phe Phe Asp Thr Thr Gln Gly His Ser Gln 
    130                 135                 140                 


Ile Asn Gly Cys Thr Val Arg Asn Val Tyr Ile Lys Glu Ala Phe Asp 
145                 150                 155                 160 


Thr Gly Val Arg Tyr Asp Phe Lys Gly Asn Phe Asp Leu Glu Gly Leu 
                165                 170                 175     


Glu Arg Gly Ile Glu Glu Val Gly Pro Asn Asn Val Pro Tyr Ile Val 
            180                 185                 190         


Ala Thr Ile Thr Ser Asn Ser Ala Gly Gly Gln Pro Val Ser Leu Ala 
        195                 200                 205             


Asn Leu Lys Val Met Tyr Ser Ile Ala Lys Lys Tyr Asp Ile Pro Val 
    210                 215                 220                 


Val Met Asp Ser Ala Arg Phe Ala Glu Asn Ala Tyr Phe Ile Lys Gln 
225                 230                 235                 240 


Arg Glu Ala Glu Tyr Lys Asp Trp Thr Ile Glu Gln Ile Thr Arg Glu 
                245                 250                 255     


Thr Tyr Lys Tyr Ala Asp Met Leu Ala Met Ser Ala Lys Lys Asp Ala 
            260                 265                 270         


Met Val Pro Met Gly Gly Leu Leu Cys Met Lys Asp Asp Ser Phe Phe 
        275                 280                 285             


Asp Val Tyr Thr Glu Cys Arg Thr Leu Cys Val Val Gln Glu Gly Phe 
    290                 295                 300                 


Pro Thr Tyr Gly Gly Leu Glu Gly Gly Ala Met Glu Arg Leu Ala Val 
305                 310                 315                 320 


Gly Leu Tyr Asp Gly Met Asn Leu Asp Trp Leu Ala Tyr Arg Ile Ala 
                325                 330                 335     


Gln Val Gln Tyr Leu Val Asp Gly Leu Glu Glu Ile Gly Val Val Cys 
            340                 345                 350         


Gln Gln Ala Gly Gly His Ala Ala Phe Val Asp Ala Gly Lys Leu Leu 
        355                 360                 365             


Pro His Ile Pro Ala Asp Gln Phe Pro Ala Gln Ala Leu Ala Cys Glu 
    370                 375                 380                 


Leu Tyr Lys Val Ala Gly Ile Arg Ala Val Glu Ile Gly Ser Phe Leu 
385                 390                 395                 400 


Leu Gly Arg Asp Pro Lys Thr Gly Lys Gln Leu Pro Cys Pro Ala Glu 
                405                 410                 415     


Leu Leu Arg Leu Thr Ile Pro Arg Ala Thr Tyr Thr Gln Thr His Met 
            420                 425                 430         


Asp Phe Ile Ile Glu Ala Phe Lys His Val Lys Glu Asn Ala Ala Asn 
        435                 440                 445             


Ile Lys Gly Leu Thr Phe Thr Tyr Glu Pro Lys Val Leu Arg His Phe 
    450                 455                 460                 


Thr Ala Lys Leu Lys Glu Val 
465                 470     


<210> 65
<211> 416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Pseudomonas kynureninase, P83788

<400> 65
Met Thr Thr Arg Asn Asp Cys Leu Ala Leu Asp Ala Gln Asp Ser Leu 
1               5                   10                  15      


Ala Pro Leu Arg Gln Gln Phe Ala Leu Pro Glu Gly Val Ile Tyr Leu 
            20                  25                  30          


Asp Gly Asn Ser Leu Gly Ala Arg Pro Val Ala Ala Leu Ala Arg Ala 
        35                  40                  45              


Gln Ala Val Ile Ala Glu Glu Trp Gly Asn Gly Leu Ile Arg Ser Trp 
    50                  55                  60                  


Asn Ser Ala Gly Trp Arg Asp Leu Ser Glu Arg Leu Gly Asn Arg Leu 
65                  70                  75                  80  


Ala Thr Leu Ile Gly Ala Arg Asp Gly Glu Val Val Val Thr Asp Thr 
                85                  90                  95      


Thr Ser Ile Asn Leu Phe Lys Val Leu Ser Ala Ala Leu Arg Val Gln 
            100                 105                 110         


Ala Thr Arg Ser Pro Glu Arg Arg Val Ile Val Thr Glu Thr Ser Asn 
        115                 120                 125             


Phe Pro Thr Asp Leu Tyr Ile Ala Glu Gly Leu Ala Asp Met Leu Gln 
    130                 135                 140                 


Gln Gly Tyr Thr Leu Arg Leu Val Asp Ser Pro Glu Glu Leu Pro Gln 
145                 150                 155                 160 


Ala Ile Asp Gln Asp Thr Ala Val Val Met Leu Thr His Val Asn Tyr 
                165                 170                 175     


Lys Thr Gly Tyr Met His Asp Met Gln Ala Leu Thr Ala Leu Ser His 
            180                 185                 190         


Glu Cys Gly Ala Leu Ala Ile Trp Asp Leu Ala His Ser Ala Gly Ala 
        195                 200                 205             


Val Pro Val Asp Leu His Gln Ala Gly Ala Asp Tyr Ala Ile Gly Cys 
    210                 215                 220                 


Thr Tyr Lys Tyr Leu Asn Gly Gly Pro Gly Ser Gln Ala Phe Val Trp 
225                 230                 235                 240 


Val Ser Pro Gln Leu Cys Asp Leu Val Pro Gln Pro Leu Ser Gly Trp 
                245                 250                 255     


Phe Gly His Ser Arg Gln Phe Ala Met Glu Pro Arg Tyr Glu Pro Ser 
            260                 265                 270         


Asn Gly Ile Ala Arg Tyr Leu Cys Gly Thr Gln Pro Ile Thr Ser Leu 
        275                 280                 285             


Ala Met Val Glu Cys Gly Leu Asp Val Phe Ala Gln Thr Asp Met Ala 
    290                 295                 300                 


Ser Leu Arg Arg Lys Ser Leu Ala Leu Thr Asp Leu Phe Ile Glu Leu 
305                 310                 315                 320 


Val Glu Gln Arg Cys Ala Ala His Glu Leu Thr Leu Val Thr Pro Arg 
                325                 330                 335     


Glu His Ala Lys Arg Gly Ser His Val Ser Phe Glu His Pro Glu Gly 
            340                 345                 350         


Tyr Ala Val Ile Gln Ala Leu Ile Asp Arg Gly Val Ile Gly Asp Tyr 
        355                 360                 365             


Arg Glu Pro Arg Ile Met Arg Phe Gly Phe Thr Pro Leu Tyr Thr Thr 
    370                 375                 380                 


Phe Thr Glu Val Trp Asp Ala Val Gln Ile Leu Gly Glu Ile Leu Asp 
385                 390                 395                 400 


Arg Lys Thr Trp Ala Gln Ala Gln Phe Gln Val Arg His Ser Val Thr 
                405                 410                 415     


<210> 66
<211> 465
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Human, Q16719

<400> 66
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile 
1               5                   10                  15      


Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His 
            20                  25                  30          


Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile 
        35                  40                  45              


Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys 
    50                  55                  60                  


Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro 
65                  70                  75                  80  


Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys 
                85                  90                  95      


Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly 
            100                 105                 110         


Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu 
        115                 120                 125             


Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu 
    130                 135                 140                 


Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu 
                165                 170                 175     


Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro 
            180                 185                 190         


Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile 
        195                 200                 205             


Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His 
    210                 215                 220                 


Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly 
225                 230                 235                 240 


Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly 
                245                 250                 255     


Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp 
            260                 265                 270         


Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala 
        275                 280                 285             


Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly 
    290                 295                 300                 


Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu 
305                 310                 315                 320 


Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile 
                325                 330                 335     


Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala 
            340                 345                 350         


Thr Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu 
        355                 360                 365             


Glu Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys 
    370                 375                 380                 


Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly 
385                 390                 395                 400 


Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln 
                405                 410                 415     


Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly 
            420                 425                 430         


Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr 
        435                 440                 445             


Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys 
    450                 455                 460                 


Asn 
465 


<210> 67
<211> 378
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Shewanella, Q8E973

<400> 67
Met Leu Leu Asn Val Lys Gln Asp Phe Cys Leu Ala Gly Pro Gly Tyr 
1               5                   10                  15      


Leu Leu Asn His Ser Val Gly Arg Pro Leu Lys Ser Thr Glu Gln Ala 
            20                  25                  30          


Leu Lys Gln Ala Phe Phe Ala Pro Trp Gln Glu Ser Gly Arg Glu Pro 
        35                  40                  45              


Trp Gly Gln Trp Leu Gly Val Ile Asp Asn Phe Thr Ala Ala Leu Ala 
    50                  55                  60                  


Ser Leu Phe Asn Gly Gln Pro Gln Asp Phe Cys Pro Gln Val Asn Leu 
65                  70                  75                  80  


Ser Ser Ala Leu Thr Lys Ile Val Met Ser Leu Asp Arg Leu Thr Arg 
                85                  90                  95      


Asp Leu Thr Arg Asn Gly Gly Ala Val Val Leu Met Ser Glu Ile Asp 
            100                 105                 110         


Phe Pro Ser Met Gly Phe Ala Leu Lys Lys Ala Leu Pro Ala Ser Cys 
        115                 120                 125             


Glu Leu Arg Phe Ile Pro Lys Ser Leu Asp Val Thr Asp Pro Asn Val 
    130                 135                 140                 


Trp Asp Ala His Ile Cys Asp Asp Val Asp Leu Val Phe Val Ser His 
145                 150                 155                 160 


Ala Tyr Ser Asn Thr Gly Gln Gln Ala Pro Leu Ala Gln Ile Ile Ser 
                165                 170                 175     


Leu Ala Arg Glu Arg Gly Cys Leu Ser Leu Val Asp Val Ala Gln Ser 
            180                 185                 190         


Ala Gly Ile Leu Pro Leu Asp Leu Ala Lys Leu Gln Pro Asp Phe Met 
        195                 200                 205             


Ile Gly Ser Ser Val Lys Trp Leu Cys Ser Gly Pro Gly Ala Ala Tyr 
    210                 215                 220                 


Leu Trp Val Asn Pro Ala Ile Leu Pro Glu Cys Gln Pro Gln Asp Val 
225                 230                 235                 240 


Gly Trp Phe Ser His Glu Asn Pro Phe Glu Phe Asp Ile His Asp Phe 
                245                 250                 255     


Arg Tyr His Pro Thr Ala Leu Arg Phe Trp Gly Gly Thr Pro Ser Ile 
            260                 265                 270         


Ala Pro Tyr Ala Ile Ala Ala His Ser Ile Glu Tyr Phe Ala Asn Ile 
        275                 280                 285             


Gly Ser Gln Val Met Arg Glu His Asn Leu Gln Leu Met Glu Pro Val 
    290                 295                 300                 


Val Gln Ala Leu Asp Asn Glu Leu Val Ser Pro Gln Glu Val Asp Lys 
305                 310                 315                 320 


Arg Ser Gly Thr Ile Ile Leu Gln Phe Gly Glu Arg Gln Pro Gln Ile 
                325                 330                 335     


Leu Ala Ala Leu Ala Ala Ala Asn Ile Ser Val Asp Thr Arg Ser Leu 
            340                 345                 350         


Gly Ile Arg Val Ser Pro His Ile Tyr Asn Asp Glu Ala Asp Ile Ala 
        355                 360                 365             


Arg Leu Leu Gly Val Ile Lys Ala Asn Arg 
    370                 375             


<210> 68
<211> 1303
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> kynU (Pseudomonas)

<400> 68
atgacgaccc gaaatgattg cctagcgttg gatgcacagg acagtctggc tccgctgcgc       60

caacaatttg cgctgccgga gggtgtgata tacctggatg gcaattcgct gggcgcacgt      120

ccggtagctg cgctggctcg cgcgcaggct gtgatcgcag aagaatgggg caacgggttg      180

atccgttcat ggaactctgc gggctggcgt gatctgtctg aacgcctggg taatcgcctg      240

gctaccctga ttggtgcgcg cgatggggaa gtagttgtta ctgataccac ctcgattaat      300

ctgtttaaag tgctgtcagc ggcgctgcgc gtgcaagcta cccgtagccc ggagcgccgt      360

gttatcgtga ctgagacctc gaatttcccg accgacctgt atattgcgga agggttggcg      420

gatatgctgc aacaaggtta cactctgcgt ttggtggatt caccggaaga gctgccacag      480

gctatagatc aggacaccgc ggtggtgatg ctgacgcacg taaattataa aaccggttat      540

atgcacgaca tgcaggctct gaccgcgttg agccacgagt gtggggctct ggcgatttgg      600

gatctggcgc actctgctgg cgctgtgccg gtggacctgc accaagcggg cgcggactat      660

gcgattggct gcacgtacaa atacctgaat ggcggcccgg gttcgcaagc gtttgtttgg      720

gtttcgccgc aactgtgcga cctggtaccg cagccgctgt ctggttggtt cggccatagt      780

cgccaattcg cgatggagcc gcgctacgaa ccttctaacg gcattgctcg ctatctgtgc      840

ggcactcagc ctattactag cttggctatg gtggagtgcg gcctggatgt gtttgcgcag      900

acggatatgg cttcgctgcg ccgtaaaagt ctggcgctga ctgatctgtt catcgagctg      960

gttgaacaac gctgcgctgc acacgaactg accctggtta ctccacgtga acacgcgaaa     1020

cgcggctctc acgtgtcttt tgaacacccc gagggttacg ctgttattca agctctgatt     1080

gatcgtggcg tgatcggcga ttaccgtgag ccacgtatta tgcgtttcgg tttcactcct     1140

ctgtatacta cttttacgga agtttgggat gcagtacaaa tcctgggcga aatcctggat     1200

cgtaagactt gggcgcaggc tcagtttcag gtgcgccact ctgttactta aaaataaaac     1260

gaaaggctca gtcgaaagac tgggcctttc gttttatctg ttg                       1303


<210> 69
<211> 1450
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> kynU(Human)

<400> 69
atggagcctt catctttaga actgccagcg gacacggtgc agcgcatcgc ggcggaactg       60

aagtgccatc cgactgatga gcgtgtggcg ctgcatctgg acgaagaaga taaactgcgc      120

cactttcgtg aatgttttta tattcctaaa attcaagact tgccgccggt agatttgagt      180

ctcgttaaca aagatgaaaa cgcgatctac tttctgggca actctctggg tctgcaacca      240

aaaatggtta aaacgtacct ggaggaagaa ctggataaat gggcaaaaat cgcggcttat      300

ggtcacgaag tgggcaagcg tccttggatt actggcgacg agtctattgt gggtttgatg      360

aaagatattg tgggcgcgaa tgaaaaggaa attgcactga tgaatgctct gaccgttaat      420

ctgcacctgc tgatgctgtc tttttttaaa ccgaccccga aacgctacaa aatactgctg      480

gaagcgaaag cgtttccgtc ggatcactat gctatagaaa gtcaactgca gttgcatggt      540

ctgaatatcg aggaatctat gcgcatgatt aaaccgcgtg agggtgaaga aacgctgcgt      600

attgaagaca ttctggaagt tattgaaaaa gaaggtgatt ctatcgcagt tatactgttt      660

tctggcgtgc acttttatac aggtcagcac ttcaatatcc cggcaatcac taaagcgggg      720

caggcaaaag gctgctatgt tggttttgac ctggcgcatg cagtggggaa tgttgaactg      780

tatctgcacg attggggcgt tgatttcgcg tgttggtgta gctacaaata tctgaacgct      840

ggcgcgggtg gcattgctgg cgcttttatt cacgaaaaac acgcgcacac cattaaaccg      900

gctctggttg gctggttcgg tcatgagctg agtactcgct ttaaaatgga taacaaactg      960

caattgattc cgggtgtttg cggcttccgt atcagcaatc cgccgattct gctggtttgc     1020

agcctgcacg ctagtctgga aatctttaag caggcgacta tgaaagcgct gcgcaaaaaa     1080

tctgtgctgc tgaccggcta tctggagtat ctgatcaaac acaattatgg caaagataaa     1140

gctgcaacta aaaaaccggt agtgaacatt atcaccccct cacacgtgga ggagcgcggt     1200

tgtcagctga ctattacttt cagtgtacct aataaagatg tgttccagga actggaaaaa     1260

cgcggcgttg tttgtgataa acgtaacccg aatggtattc gcgtggctcc tgtgccgctg     1320

tacaattcat tccacgatgt ttataaattc accaacctgc tgacttctat tctcgacagt     1380

gctgagacta aaaattaaaa ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt     1440

ttatctgttg                                                            1450


<210> 70
<211> 1189
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> kynU(Shewanella)

<400> 70
atgctgctga atgtaaaaca ggacttttgc ctggcaggcc cgggctacct gctgaatcac       60

tcggttggcc gtccgctgaa atcaactgag caagcgctga aacaagcatt ttttgctccg      120

tggcaagaga gcggtcgtga accgtggggc cagtggctgg gtgttattga taatttcact      180

gctgcgctgg catctctgtt taatggtcaa ccgcaggatt tttgtccgca ggttaacctg      240

agcagcgcgc tgactaaaat tgtgatgtca ctggatcgtc tgactcgcga tctgacccgc      300

aatggcggtg ctgttgtgct gatgtctgaa atcgatttcc catctatggg cttcgcgttg      360

aaaaaagcgc tgccagcgag ctgcgaactg cgttttatcc cgaaaagtct ggacgtgact      420

gatccgaacg tatgggatgc acacatctgt gatgatgtag acctggtttt tgtgtctcac      480

gcctatagta atacgggcca acaggctccg ctggcgcaaa tcatctctct ggcgcgtgaa      540

cgtggctgcc tgtcactggt ggatgtagcg caatcagcgg ggattttgcc gctggatctg      600

gcgaaactgc aaccggactt catgatcggc agttcggtta aatggctgtg ctcgggccct      660

ggtgcggcat atctgtgggt taatccggcg attctgccgg aatgtcagcc gcaggatgtg      720

ggctggtttt cacatgagaa tccctttgaa ttcgacatcc acgatttccg ctaccacccg      780

actgcactgc gcttttgggg tggtacgccg tcgatcgcgc cttatgcgat cgcggcgcac      840

tcgatcgaat attttgccaa tatcggctcg caagtgatgc gtgaacacaa cctgcaactg      900

atggaaccgg tggttcaggc gctggacaat gaactggtga gcccgcagga agtggataaa      960

cgctcaggca ctattattct gcaattcggt gaacgtcaac cgcaaattct ggcggctctg     1020

gctgcggcga acatttcggt ggacactcgt tctttgggga ttcgtgttag tccgcacatt     1080

tataatgatg aggcggacat tgcgcgcctg ctgggtgtga tcaaagcaaa tcgctaaaaa     1140

taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttg                 1189


<210> 71
<211> 1242
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> nupC (polynucleotide)

<400> 71
gtgcacggaa atttaacctg cctcatattt ggagcaaata tggaccgcgt ccttcatttt       60

gtactggcac ttgccgttgt tgcgattctc gcactgctgg taagcagcga ccgcaaaaaa      120

attcgtatcc gttatgttat tcaactgctt gttatcgaag tgttactggc gtggttcttc      180

ctgaactccg acgttggtct gggcttcgtg aaaggcttct ccgaaatgtt cgaaaaactg      240

ctcggttttg ccaacgaagg gactaacttc gtctttggta gcatgaatga tcaaggcctg      300

gcattcttct tcctgaaagt gctgtgccca atcgtcttta tctctgcgct gatcggtatt      360

ctccagcata ttcgcgtatt gccggtgatt atccgcgcaa ttggtttcct gctctccaaa      420

gtcaacggca tgggcaaact ggaatccttt aacgccgtca gctccctgat tctgggtcag      480

tctgaaaact ttattgccta taaagatatc ctcggcaaaa tctcccgcaa tcgtatgtac      540

accatggcag caacggcgat gtccaccgtg tcgatgtcca tcgttggtgc atatatgacc      600

atgctggagc cgaaatacgt cgttgcggcg ctggtactga acatgttcag cacctttatc      660

gtgctgtcgc tgatcaaccc ttaccgtgtt gatgccagtg aagaaaacat tcagatgtcc      720

aacctgcacg aaggtcagag cttcttcgaa atgctgggtg aatacattct ggcaggtttc      780

aaagttgcca ttatcgttgc cgcgatgctg atcggcttta tcgccctgat cgctgcactg      840

aacgctctgt ttgctaccgt gactggctgg tttggctaca gcatctcctt ccagggcatc      900

ctgggttaca tcttctatcc gattgcatgg gtgatgggtg ttccttccag tgaagcactg      960

caagtgggca gtatcatggc gaccaaactg gtttccaacg agttcgttgc gatgatggat     1020

ctgcagaaaa ttgcttccac gctctctccg cgtgcggaag gcatcatctc tgtgttcctg     1080

gtttccttcg ctaacttctc ttcaatcggg attatcgcgg gtgcggttaa aggcctgaat     1140

gaagagcaag gtaacgtggt ttctcgcttc ggtctgaaac tggtttacgg ctctaccctg     1200

gtgagtgtgc tgtctgcgtc aatcgcagca ctggtgctgt aa                        1242


<210> 72
<211> 2259
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> xdhA

<400> 72
atgcgcgtcg atgccattgc taaggtcacc gggcgggcac gatatactga cgattatatt       60

atggcgggca tgtgttacgc gaaatatgta cgtagcccta tcgcacatgg ttatgctgta      120

aatattaatg atgaacaagc caggagtttg ccgggcgtcc tggcgatttt tacctgggaa      180

gatgtgccag aaatcccatt cgccacggca gggcatgcct ggacacttga cgaaaacaag      240

cgcgataccg ccgatcgtgc cctgctaacg cgtcatgttc gtcatcatgg tgacgccgtt      300

gccatcgtcg tggcccgcga tgaactcacg gcagaaaaag cggcgcaatt ggtcagcatt      360

gagtggcaag aattacccgt tatcacctcg ccagaagcgg cgctggcaga agacgctgca      420

ccaatccata acggtggcaa tttactgaaa caaagcacga tgtcgacggg taatgtccaa      480

caaacaatcg atgccgccga ctaccaggta caggggcact atcagactcc cgttattcaa      540

cattgtcata tggaaagcgt gacatcgctg gcatggatgg aggatgactc gcgaattacc      600

atcgtttcca gcacccagat cccgcacatt gttcgccgcg tggttggtca ggcgctggat      660

attccctggt catgcgtacg agtcatcaaa ccgtttatcg gtggcggttt tggtaataaa      720

caggatgtac tggaagagcc aatggcggca ttcctgacca gcaaacttgg cggcattccg      780

gtgaaagttt cccttagccg tgaagagtgt ttcctcgcaa cccgtacccg ccacgctttt      840

actattgacg ggcaaatggg cgtgaaccgc gacggaacat tgaaaggtta tagtctggat      900

gttctgtcta acaccggcgc ttatgcatct cacgggcact ccattgcttc tgctgggggg      960

aataaagtcg cttaccttta tcctcgttgt gcctacgctt acagttcaaa gacctgctat     1020

accaacctcc cctcggctgg tgcgatgcgt ggttatggcg cgccacaagt cgtatttgcc     1080

gttgagtcta tgcttgatga tgccgcgaca gcgttaggta ttgatcctgt tgaaattcgt     1140

ttacgcaacg ccgcccgcga aggagatgct aatccgctca cgggaaaacg tatttacagc     1200

gcagggttgc cggagtgtct tgaaaaaggc cggaaaatct ttgaatggga aaaacgccgt     1260

gcagagtgcc agaaccagca aggcaattta cgtcgtggcg ttggcgtcgc ctgttttagc     1320

tacacctcta acacctggcc tgtcggcgta gaaatagcag gcgcgcgcct gttgatgaat     1380

caggatggaa ccatcaacgt gcaaagcggc gcgacggaaa tcggccaggg tgccgacacc     1440

gtgttctcgc aaatggtggc agaaaccgtg ggagttccgg tcagcgatgt tcacgttatt     1500

tcaacccaag ataccgacgt tacaccattc gaccccggcg catttgcctc acgtcagagc     1560

tatgttgccg cgcctgcgct gcgcagtgca gcactgttat taaaagagaa aatcatcgct     1620

cacgccgcag tcatgctaca tcagtcagcg atgaatctga ccctgataaa aggccatatc     1680

gtgctgattg aaagaccgga agaaccgtta atgtcgttaa aagatttggc gatggacgct     1740

ttctaccacc ctgaacgcgg cgggcagctc tctgccgaaa gctccatcaa aaccaccact     1800

aacccaccgg cgtttggctg tacctttgtt gatctgacgg tcgatattgc actgtgcaaa     1860

gtcaccatca accgcatcct caacgttcat gattcgggcc atattcttaa tccgctgctg     1920

gcagaaggtc aggtacacgg cggaatggga atgggcattg gctgggcgct atttgaagag     1980

atgatcatcg atgcgaaaag cggcgtggtc cgtaacccca atctgctgga ttacaaaatg     2040

ccgaccatgc cggatctgcc acaactggaa agcgcgttcg tcgaaatcaa tgagccgcaa     2100

tcagcatacg gacataagtc actgggtgag ccccccataa ttcctgtagc cgctgctatt     2160

cgtaacgcgg tgaagatggc taccggtgtt gcaatcaata cactgccgct aacgccaaaa     2220

cgattatatg aagaattcca tctggcagga ttgatttga                            2259


<210> 73
<211> 879
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> xdhB

<400> 73
atgtttgatt ttgcttctta ccatcgcgca accacccttg ccgatgccat caccctgctg       60

gctgacaatc cgcaggccaa attgcttgcc ggtggcactg acgtactgat acagcttcac      120

catcacaatg accgctatcg ccatattgtt gatatccaca atctggcaga gcttcaggga      180

ataacacagg cggaagatgg cgcgctgcga atcggctctg cgacaacatt tactcagctc      240

attgaagatc ccgtaatcca acgcaatctc ccggcgttat gtgctgcggc tgcatcaatc      300

gccgggccgc agatccgtaa tgtcgccacc tacggcggaa atatttgcaa cggtgccacc      360

agcgcagatt ctgccacgcc aacgctaatt tatgacgcga aactggagct ccactcccca      420

cgcggtgttc gtttcgtccc gattaatggc tttcacaccg ggccgggcaa agtgtctctt      480

gagcatgacg aaatccttgt cgcctttcat tttccgccac agccgaaaga acacgcgggc      540

agcgcgcatt ttaaatatgc catgcgcgac gcaatggata tttcaacaat tggctgcgcc      600

gcacattgcc gactggataa cggcaatttc agcgaattac gcctggcatt tggtgttgcc      660

gcgccaacgc cgattcgctg ccaacatgcc gaacagactg cacaaaatgc gccattaaac      720

ctgcaaacgc tggaagccat cagcgaatca gtcctgcaag atgtcgcccc gcgttcttca      780

tggcgggcca gtaaagagtt tcgtctgcat ctcatccaga cgatgaccaa aaaagtgatt      840

agcgaagccg tcgccgcggc ggggggaaaa ttgcaatga                             879


<210> 74
<211> 480
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> xdhC

<400> 74
atgaatcaca gcgaaacaat taccatcgaa tgcaccatta acgggatgcc ttttcagctt       60

cacgccgcgc caggaatgcc gctttcggaa ctactccgag aacaagggct tcttagtgtc      120

aaacaaggtt gctgcgtagg cgaatgcggt gcctgtacgg tgctggtcga cggcactgcg      180

atagacagtt gcttattcct tgcgacctgg gctgaaggaa aagagatccg cacgctggaa      240

ggtgaagcga aaggcggtaa actttctcat gtccaactgg cttatgcgaa atctggtgca      300

gtgcaatgcg ggttttgtac gccgggcctg attatggcta ccacggcgat gctggcaaaa      360

ccacgcgaaa aaccattaac cattacggaa attcgtcgtg gactggcggg aaatctttgt      420

cgctgcacgg ggtatcagat gattgtaaat acagttctgg attgcgagaa aacgaagtaa      480


<210> 75
<211> 1002
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Add

<400> 75
atgattgata ccaccctgcc attaactgat atccatcgcc accttgatgg caacattcgt       60

ccccagacca ttcttgaact tggccgccag tataatatct cgcttcctgc acaatccctg      120

gaaacactga ttccccacgt tcaggtcatt gccaacgaac ccgatctggt gagctttctg      180

actaaacttg actggggcgt taaagttctc gcctctcttg atgcctgccg ccgcgtggca      240

tttgaaaaca ttgaagatgc agcccgtaac ggcctgcact atgtcgagct gcgtttttca      300

ccaggctaca tggcaatggc acatcagctg cctgtagcgg gtgttgtcga agcggtgatc      360

gatggcgtac gtgaaggttg ccgcaccttt ggtgtgcagg cgaagcttat cggtattatg      420

agccggacct tcggcgaagc cgcctgtcag caagagctgg aggccttttt agcccaccgt      480

gaccagatta ccgcacttga tttagccggt gatgaacttg gtttcccggg aagtctgttc      540

ctttctcatt tcaaccgcgc gcgtgatgcg ggctggcata ttaccgtcca tgcaggcgaa      600

gctgccggac cggaaagcat ctggcaggcg attcgtgaac tgggggcgga gcgtattgga      660

catggcgtaa aagccattga agatcgggcg ctgatggatt ttctcgccga gcaacaaatt      720

ggtattgaat cctgtctgac ctccaatatt cagaccagca ccgtggcgga tctggctgca      780

catccgctga aaacgttcct tgagcatggc attcgtgcca gcattaacac tgacgatcca      840

ggcgtgcagg gagtggatat cattcacgaa tataccgttg ccgcgccagc tgctgggtta      900

tcccgcgagc aaatccgcca ggcacagatt aatggtctgg aaatggcttt cctcagcgca      960

gaggaaaaac gcgcactgcg agaaaaagtc gccgcgaagt aa                        1002


<210> 76
<211> 834
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> xapA

<400> 76
atgtatcagg ctcagttttc tcataaccca ctgtattgcg tagatattat caagacttat       60

aaacctgatt tcacgccacg agtggccttt attttaggtt ccgggctggg cgcgctggcc      120

gatcagattg agaacgcggt cgcaatttcc tacgaaaagc tgcctgggtt cccggtaagt      180

accgtacacg gtcatgcggg tgagctggtg ctgggttatc tccagggggt gccagtggcg      240

tgtatgaaag gtcgcggaca tttctacgaa ggtcgtggga tgaccatcat gacggatgca      300

atccgtacct ttaagttgct gggctgcgag ttgctgttct gcaccaatgc ggctggctca      360

ctgcgccctg aagtgggggc cggcagtctg gtcgcattga aagatcacat caacaccatg      420

ccgggaacgc cgatggtggg tcttaatgat gaacgttttg gtgagcgctt cttctcgctg      480

gcgaatgcct acgatgcgga ataccgcgca ctgttacaaa aagtggcgaa agaagagggg      540

ttccctctga cggagggcgt gttcgtctca tatccggggc cgaatttcga gactgcggcg      600

gaaattcgca tgatgcaaat tattggtggg gatgttgttg gtatgtctgt ggtgcctgag      660

gttatttcag ctcgccattg cgaacttaaa gtcgttgcgg tctctgcgat taccaacatg      720

gcggaaggtc tgagtgacgt gaagctttct catgcccaaa cgctggcagc agcggaactc      780

tcaaagcaaa actttattaa tcttatttgc ggctttctgc gcaaaattgc ctga            834


<210> 77
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> deoD

<400> 77
atggctaccc cacacattaa tgcagaaatg ggcgatttcg ctgacgtagt tttgatgcca       60

ggcgacccgc tgcgtgcgaa gtatattgct gaaactttcc ttgaagatgc ccgtgaagtg      120

aacaacgttc gcggtatgct gggcttcacc ggtacttaca aaggccgcaa aatttccgta      180

atgggtcacg gtatgggtat cccgtcctgc tccatctaca ccaaagaact gatcaccgat      240

ttcggcgtga agaaaattat ccgcgtgggt tcctgtggcg cagttctgcc gcacgtaaaa      300

ctacgcgacg tcgttatcgg tatgggtgcc tgcaccgatt ccaaagttaa ccgcatccgt      360

tttaaagacc atgactttgc cgctatcgct gactttgaca tggtgcgtaa cgcggtagac      420

gcggctaaag cactgggcgt tgatgctcgc gtgggtaacc tgttctccgc tgacctgttc      480

tactctccgg acggcgaaat gttcgacgtg atggaaaaat acggcatcct cggcgtggaa      540

atggaagcgg ctggtatcta cggcgtcgct gcagaatttg gcgcgaaagc cctgaccatc      600

tgcaccgtgt ctgaccacat ccgcactcac gagcagacca ctgccgctga gcgtcagacc      660

accttcaacg acatgatcaa aatcgcactg gaatccgttc tgctgggcga taaagagtaa      720


<210> 78
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> NupC (polypeptide)

<400> 78
Val His Gly Asn Leu Thr Cys Leu Ile Phe Gly Ala Asn Met Asp Arg 
1               5                   10                  15      


Val Leu His Phe Val Leu Ala Leu Ala Val Val Ala Ile Leu Ala Leu 
            20                  25                  30          


Leu Val Ser Ser Asp Arg Lys Lys Ile Arg Ile Arg Tyr Val Ile Gln 
        35                  40                  45              


Leu Leu Val Ile Glu Val Leu Leu Ala Trp Phe Phe Leu Asn Ser Asp 
    50                  55                  60                  


Val Gly Leu Gly Phe Val Lys Gly Phe Ser Glu Met Phe Glu Lys Leu 
65                  70                  75                  80  


Leu Gly Phe Ala Asn Glu Gly Thr Asn Phe Val Phe Gly Ser Met Asn 
                85                  90                  95      


Asp Gln Gly Leu Ala Phe Phe Phe Leu Lys Val Leu Cys Pro Ile Val 
            100                 105                 110         


Phe Ile Ser Ala Leu Ile Gly Ile Leu Gln His Ile Arg Val Leu Pro 
        115                 120                 125             


Val Ile Ile Arg Ala Ile Gly Phe Leu Leu Ser Lys Val Asn Gly Met 
    130                 135                 140                 


Gly Lys Leu Glu Ser Phe Asn Ala Val Ser Ser Leu Ile Leu Gly Gln 
145                 150                 155                 160 


Ser Glu Asn Phe Ile Ala Tyr Lys Asp Ile Leu Gly Lys Ile Ser Arg 
                165                 170                 175     


Asn Arg Met Tyr Thr Met Ala Ala Thr Ala Met Ser Thr Val Ser Met 
            180                 185                 190         


Ser Ile Val Gly Ala Tyr Met Thr Met Leu Glu Pro Lys Tyr Val Val 
        195                 200                 205             


Ala Ala Leu Val Leu Asn Met Phe Ser Thr Phe Ile Val Leu Ser Leu 
    210                 215                 220                 


Ile Asn Pro Tyr Arg Val Asp Ala Ser Glu Glu Asn Ile Gln Met Ser 
225                 230                 235                 240 


Asn Leu His Glu Gly Gln Ser Phe Phe Glu Met Leu Gly Glu Tyr Ile 
                245                 250                 255     


Leu Ala Gly Phe Lys Val Ala Ile Ile Val Ala Ala Met Leu Ile Gly 
            260                 265                 270         


Phe Ile Ala Leu Ile Ala Ala Leu Asn Ala Leu Phe Ala Thr Val Thr 
        275                 280                 285             


Gly Trp Phe Gly Tyr Ser Ile Ser Phe Gln Gly Ile Leu Gly Tyr Ile 
    290                 295                 300                 


Phe Tyr Pro Ile Ala Trp Val Met Gly Val Pro Ser Ser Glu Ala Leu 
305                 310                 315                 320 


Gln Val Gly Ser Ile Met Ala Thr Lys Leu Val Ser Asn Glu Phe Val 
                325                 330                 335     


Ala Met Met Asp Leu Gln Lys Ile Ala Ser Thr Leu Ser Pro Arg Ala 
            340                 345                 350         


Glu Gly Ile Ile Ser Val Phe Leu Val Ser Phe Ala Asn Phe Ser Ser 
        355                 360                 365             


Ile Gly Ile Ile Ala Gly Ala Val Lys Gly Leu Asn Glu Glu Gln Gly 
    370                 375                 380                 


Asn Val Val Ser Arg Phe Gly Leu Lys Leu Val Tyr Gly Ser Thr Leu 
385                 390                 395                 400 


Val Ser Val Leu Ser Ala Ser Ile Ala Ala Leu Val Leu 
                405                 410             


<210> 79
<211> 752
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> xdhA (polypeptide)

<400> 79
Met Arg Val Asp Ala Ile Ala Lys Val Thr Gly Arg Ala Arg Tyr Thr 
1               5                   10                  15      


Asp Asp Tyr Ile Met Ala Gly Met Cys Tyr Ala Lys Tyr Val Arg Ser 
            20                  25                  30          


Pro Ile Ala His Gly Tyr Ala Val Asn Ile Asn Asp Glu Gln Ala Arg 
        35                  40                  45              


Ser Leu Pro Gly Val Leu Ala Ile Phe Thr Trp Glu Asp Val Pro Glu 
    50                  55                  60                  


Ile Pro Phe Ala Thr Ala Gly His Ala Trp Thr Leu Asp Glu Asn Lys 
65                  70                  75                  80  


Arg Asp Thr Ala Asp Arg Ala Leu Leu Thr Arg His Val Arg His His 
                85                  90                  95      


Gly Asp Ala Val Ala Ile Val Val Ala Arg Asp Glu Leu Thr Ala Glu 
            100                 105                 110         


Lys Ala Ala Gln Leu Val Ser Ile Glu Trp Gln Glu Leu Pro Val Ile 
        115                 120                 125             


Thr Ser Pro Glu Ala Ala Leu Ala Glu Asp Ala Ala Pro Ile His Asn 
    130                 135                 140                 


Gly Gly Asn Leu Leu Lys Gln Ser Thr Met Ser Thr Gly Asn Val Gln 
145                 150                 155                 160 


Gln Thr Ile Asp Ala Ala Asp Tyr Gln Val Gln Gly His Tyr Gln Thr 
                165                 170                 175     


Pro Val Ile Gln His Cys His Met Glu Ser Val Thr Ser Leu Ala Trp 
            180                 185                 190         


Met Glu Asp Asp Ser Arg Ile Thr Ile Val Ser Ser Thr Gln Ile Pro 
        195                 200                 205             


His Ile Val Arg Arg Val Val Gly Gln Ala Leu Asp Ile Pro Trp Ser 
    210                 215                 220                 


Cys Val Arg Val Ile Lys Pro Phe Ile Gly Gly Gly Phe Gly Asn Lys 
225                 230                 235                 240 


Gln Asp Val Leu Glu Glu Pro Met Ala Ala Phe Leu Thr Ser Lys Leu 
                245                 250                 255     


Gly Gly Ile Pro Val Lys Val Ser Leu Ser Arg Glu Glu Cys Phe Leu 
            260                 265                 270         


Ala Thr Arg Thr Arg His Ala Phe Thr Ile Asp Gly Gln Met Gly Val 
        275                 280                 285             


Asn Arg Asp Gly Thr Leu Lys Gly Tyr Ser Leu Asp Val Leu Ser Asn 
    290                 295                 300                 


Thr Gly Ala Tyr Ala Ser His Gly His Ser Ile Ala Ser Ala Gly Gly 
305                 310                 315                 320 


Asn Lys Val Ala Tyr Leu Tyr Pro Arg Cys Ala Tyr Ala Tyr Ser Ser 
                325                 330                 335     


Lys Thr Cys Tyr Thr Asn Leu Pro Ser Ala Gly Ala Met Arg Gly Tyr 
            340                 345                 350         


Gly Ala Pro Gln Val Val Phe Ala Val Glu Ser Met Leu Asp Asp Ala 
        355                 360                 365             


Ala Thr Ala Leu Gly Ile Asp Pro Val Glu Ile Arg Leu Arg Asn Ala 
    370                 375                 380                 


Ala Arg Glu Gly Asp Ala Asn Pro Leu Thr Gly Lys Arg Ile Tyr Ser 
385                 390                 395                 400 


Ala Gly Leu Pro Glu Cys Leu Glu Lys Gly Arg Lys Ile Phe Glu Trp 
                405                 410                 415     


Glu Lys Arg Arg Ala Glu Cys Gln Asn Gln Gln Gly Asn Leu Arg Arg 
            420                 425                 430         


Gly Val Gly Val Ala Cys Phe Ser Tyr Thr Ser Asn Thr Trp Pro Val 
        435                 440                 445             


Gly Val Glu Ile Ala Gly Ala Arg Leu Leu Met Asn Gln Asp Gly Thr 
    450                 455                 460                 


Ile Asn Val Gln Ser Gly Ala Thr Glu Ile Gly Gln Gly Ala Asp Thr 
465                 470                 475                 480 


Val Phe Ser Gln Met Val Ala Glu Thr Val Gly Val Pro Val Ser Asp 
                485                 490                 495     


Val His Val Ile Ser Thr Gln Asp Thr Asp Val Thr Pro Phe Asp Pro 
            500                 505                 510         


Gly Ala Phe Ala Ser Arg Gln Ser Tyr Val Ala Ala Pro Ala Leu Arg 
        515                 520                 525             


Ser Ala Ala Leu Leu Leu Lys Glu Lys Ile Ile Ala His Ala Ala Val 
    530                 535                 540                 


Met Leu His Gln Ser Ala Met Asn Leu Thr Leu Ile Lys Gly His Ile 
545                 550                 555                 560 


Val Leu Ile Glu Arg Pro Glu Glu Pro Leu Met Ser Leu Lys Asp Leu 
                565                 570                 575     


Ala Met Asp Ala Phe Tyr His Pro Glu Arg Gly Gly Gln Leu Ser Ala 
            580                 585                 590         


Glu Ser Ser Ile Lys Thr Thr Thr Asn Pro Pro Ala Phe Gly Cys Thr 
        595                 600                 605             


Phe Val Asp Leu Thr Val Asp Ile Ala Leu Cys Lys Val Thr Ile Asn 
    610                 615                 620                 


Arg Ile Leu Asn Val His Asp Ser Gly His Ile Leu Asn Pro Leu Leu 
625                 630                 635                 640 


Ala Glu Gly Gln Val His Gly Gly Met Gly Met Gly Ile Gly Trp Ala 
                645                 650                 655     


Leu Phe Glu Glu Met Ile Ile Asp Ala Lys Ser Gly Val Val Arg Asn 
            660                 665                 670         


Pro Asn Leu Leu Asp Tyr Lys Met Pro Thr Met Pro Asp Leu Pro Gln 
        675                 680                 685             


Leu Glu Ser Ala Phe Val Glu Ile Asn Glu Pro Gln Ser Ala Tyr Gly 
    690                 695                 700                 


His Lys Ser Leu Gly Glu Pro Pro Ile Ile Pro Val Ala Ala Ala Ile 
705                 710                 715                 720 


Arg Asn Ala Val Lys Met Ala Thr Gly Val Ala Ile Asn Thr Leu Pro 
                725                 730                 735     


Leu Thr Pro Lys Arg Leu Tyr Glu Glu Phe His Leu Ala Gly Leu Ile 
            740                 745                 750         


<210> 80
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> xdhB (polypeptide)

<400> 80
Met Phe Asp Phe Ala Ser Tyr His Arg Ala Thr Thr Leu Ala Asp Ala 
1               5                   10                  15      


Ile Thr Leu Leu Ala Asp Asn Pro Gln Ala Lys Leu Leu Ala Gly Gly 
            20                  25                  30          


Thr Asp Val Leu Ile Gln Leu His His His Asn Asp Arg Tyr Arg His 
        35                  40                  45              


Ile Val Asp Ile His Asn Leu Ala Glu Leu Gln Gly Ile Thr Gln Ala 
    50                  55                  60                  


Glu Asp Gly Ala Leu Arg Ile Gly Ser Ala Thr Thr Phe Thr Gln Leu 
65                  70                  75                  80  


Ile Glu Asp Pro Val Ile Gln Arg Asn Leu Pro Ala Leu Cys Ala Ala 
                85                  90                  95      


Ala Ala Ser Ile Ala Gly Pro Gln Ile Arg Asn Val Ala Thr Tyr Gly 
            100                 105                 110         


Gly Asn Ile Cys Asn Gly Ala Thr Ser Ala Asp Ser Ala Thr Pro Thr 
        115                 120                 125             


Leu Ile Tyr Asp Ala Lys Leu Glu Leu His Ser Pro Arg Gly Val Arg 
    130                 135                 140                 


Phe Val Pro Ile Asn Gly Phe His Thr Gly Pro Gly Lys Val Ser Leu 
145                 150                 155                 160 


Glu His Asp Glu Ile Leu Val Ala Phe His Phe Pro Pro Gln Pro Lys 
                165                 170                 175     


Glu His Ala Gly Ser Ala His Phe Lys Tyr Ala Met Arg Asp Ala Met 
            180                 185                 190         


Asp Ile Ser Thr Ile Gly Cys Ala Ala His Cys Arg Leu Asp Asn Gly 
        195                 200                 205             


Asn Phe Ser Glu Leu Arg Leu Ala Phe Gly Val Ala Ala Pro Thr Pro 
    210                 215                 220                 


Ile Arg Cys Gln His Ala Glu Gln Thr Ala Gln Asn Ala Pro Leu Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Glu Ala Ile Ser Glu Ser Val Leu Gln Asp Val Ala 
                245                 250                 255     


Pro Arg Ser Ser Trp Arg Ala Ser Lys Glu Phe Arg Leu His Leu Ile 
            260                 265                 270         


Gln Thr Met Thr Lys Lys Val Ile Ser Glu Ala Val Ala Ala Ala Gly 
        275                 280                 285             


Gly Lys Leu Gln 
    290         


<210> 81
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> xdhC (polypeptide)

<400> 81
Met Phe Asp Phe Ala Ser Tyr His Arg Ala Thr Thr Leu Ala Asp Ala 
1               5                   10                  15      


Ile Thr Leu Leu Ala Asp Asn Pro Gln Ala Lys Leu Leu Ala Gly Gly 
            20                  25                  30          


Thr Asp Val Leu Ile Gln Leu His His His Asn Asp Arg Tyr Arg His 
        35                  40                  45              


Ile Val Asp Ile His Asn Leu Ala Glu Leu Gln Gly Ile Thr Gln Ala 
    50                  55                  60                  


Glu Asp Gly Ala Leu Arg Ile Gly Ser Ala Thr Thr Phe Thr Gln Leu 
65                  70                  75                  80  


Ile Glu Asp Pro Val Ile Gln Arg Asn Leu Pro Ala Leu Cys Ala Ala 
                85                  90                  95      


Ala Ala Ser Ile Ala Gly Pro Gln Ile Arg Asn Val Ala Thr Tyr Gly 
            100                 105                 110         


Gly Asn Ile Cys Asn Gly Ala Thr Ser Ala Asp Ser Ala Thr Pro Thr 
        115                 120                 125             


Leu Ile Tyr Asp Ala Lys Leu Glu Leu His Ser Pro Arg Gly Val Arg 
    130                 135                 140                 


Phe Val Pro Ile Asn Gly Phe His Thr Gly Pro Gly Lys Val Ser Leu 
145                 150                 155                 160 


Glu His Asp Glu Ile Leu Val Ala Phe His Phe Pro Pro Gln Pro Lys 
                165                 170                 175     


Glu His Ala Gly Ser Ala His Phe Lys Tyr Ala Met Arg Asp Ala Met 
            180                 185                 190         


Asp Ile Ser Thr Ile Gly Cys Ala Ala His Cys Arg Leu Asp Asn Gly 
        195                 200                 205             


Asn Phe Ser Glu Leu Arg Leu Ala Phe Gly Val Ala Ala Pro Thr Pro 
    210                 215                 220                 


Ile Arg Cys Gln His Ala Glu Gln Thr Ala Gln Asn Ala Pro Leu Asn 
225                 230                 235                 240 


Leu Gln Thr Leu Glu Ala Ile Ser Glu Ser Val Leu Gln Asp Val Ala 
                245                 250                 255     


Pro Arg Ser Ser Trp Arg Ala Ser Lys Glu Phe Arg Leu His Leu Ile 
            260                 265                 270         


Gln Thr Met Thr Lys Lys Val Ile Ser Glu Ala Val Ala Ala Ala Gly 
        275                 280                 285             


Gly Lys Leu Gln 
    290         


<210> 82
<211> 333
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Add (polypeptide)

<400> 82
Met Ile Asp Thr Thr Leu Pro Leu Thr Asp Ile His Arg His Leu Asp 
1               5                   10                  15      


Gly Asn Ile Arg Pro Gln Thr Ile Leu Glu Leu Gly Arg Gln Tyr Asn 
            20                  25                  30          


Ile Ser Leu Pro Ala Gln Ser Leu Glu Thr Leu Ile Pro His Val Gln 
        35                  40                  45              


Val Ile Ala Asn Glu Pro Asp Leu Val Ser Phe Leu Thr Lys Leu Asp 
    50                  55                  60                  


Trp Gly Val Lys Val Leu Ala Ser Leu Asp Ala Cys Arg Arg Val Ala 
65                  70                  75                  80  


Phe Glu Asn Ile Glu Asp Ala Ala Arg Asn Gly Leu His Tyr Val Glu 
                85                  90                  95      


Leu Arg Phe Ser Pro Gly Tyr Met Ala Met Ala His Gln Leu Pro Val 
            100                 105                 110         


Ala Gly Val Val Glu Ala Val Ile Asp Gly Val Arg Glu Gly Cys Arg 
        115                 120                 125             


Thr Phe Gly Val Gln Ala Lys Leu Ile Gly Ile Met Ser Arg Thr Phe 
    130                 135                 140                 


Gly Glu Ala Ala Cys Gln Gln Glu Leu Glu Ala Phe Leu Ala His Arg 
145                 150                 155                 160 


Asp Gln Ile Thr Ala Leu Asp Leu Ala Gly Asp Glu Leu Gly Phe Pro 
                165                 170                 175     


Gly Ser Leu Phe Leu Ser His Phe Asn Arg Ala Arg Asp Ala Gly Trp 
            180                 185                 190         


His Ile Thr Val His Ala Gly Glu Ala Ala Gly Pro Glu Ser Ile Trp 
        195                 200                 205             


Gln Ala Ile Arg Glu Leu Gly Ala Glu Arg Ile Gly His Gly Val Lys 
    210                 215                 220                 


Ala Ile Glu Asp Arg Ala Leu Met Asp Phe Leu Ala Glu Gln Gln Ile 
225                 230                 235                 240 


Gly Ile Glu Ser Cys Leu Thr Ser Asn Ile Gln Thr Ser Thr Val Ala 
                245                 250                 255     


Asp Leu Ala Ala His Pro Leu Lys Thr Phe Leu Glu His Gly Ile Arg 
            260                 265                 270         


Ala Ser Ile Asn Thr Asp Asp Pro Gly Val Gln Gly Val Asp Ile Ile 
        275                 280                 285             


His Glu Tyr Thr Val Ala Ala Pro Ala Ala Gly Leu Ser Arg Glu Gln 
    290                 295                 300                 


Ile Arg Gln Ala Gln Ile Asn Gly Leu Glu Met Ala Phe Leu Ser Ala 
305                 310                 315                 320 


Glu Glu Lys Arg Ala Leu Arg Glu Lys Val Ala Ala Lys 
                325                 330             


<210> 83
<211> 277
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> xapA (polypeptide)

<400> 83
Met Tyr Gln Ala Gln Phe Ser His Asn Pro Leu Tyr Cys Val Asp Ile 
1               5                   10                  15      


Ile Lys Thr Tyr Lys Pro Asp Phe Thr Pro Arg Val Ala Phe Ile Leu 
            20                  25                  30          


Gly Ser Gly Leu Gly Ala Leu Ala Asp Gln Ile Glu Asn Ala Val Ala 
        35                  40                  45              


Ile Ser Tyr Glu Lys Leu Pro Gly Phe Pro Val Ser Thr Val His Gly 
    50                  55                  60                  


His Ala Gly Glu Leu Val Leu Gly Tyr Leu Gln Gly Val Pro Val Ala 
65                  70                  75                  80  


Cys Met Lys Gly Arg Gly His Phe Tyr Glu Gly Arg Gly Met Thr Ile 
                85                  90                  95      


Met Thr Asp Ala Ile Arg Thr Phe Lys Leu Leu Gly Cys Glu Leu Leu 
            100                 105                 110         


Phe Cys Thr Asn Ala Ala Gly Ser Leu Arg Pro Glu Val Gly Ala Gly 
        115                 120                 125             


Ser Leu Val Ala Leu Lys Asp His Ile Asn Thr Met Pro Gly Thr Pro 
    130                 135                 140                 


Met Val Gly Leu Asn Asp Glu Arg Phe Gly Glu Arg Phe Phe Ser Leu 
145                 150                 155                 160 


Ala Asn Ala Tyr Asp Ala Glu Tyr Arg Ala Leu Leu Gln Lys Val Ala 
                165                 170                 175     


Lys Glu Glu Gly Phe Pro Leu Thr Glu Gly Val Phe Val Ser Tyr Pro 
            180                 185                 190         


Gly Pro Asn Phe Glu Thr Ala Ala Glu Ile Arg Met Met Gln Ile Ile 
        195                 200                 205             


Gly Gly Asp Val Val Gly Met Ser Val Val Pro Glu Val Ile Ser Ala 
    210                 215                 220                 


Arg His Cys Glu Leu Lys Val Val Ala Val Ser Ala Ile Thr Asn Met 
225                 230                 235                 240 


Ala Glu Gly Leu Ser Asp Val Lys Leu Ser His Ala Gln Thr Leu Ala 
                245                 250                 255     


Ala Ala Glu Leu Ser Lys Gln Asn Phe Ile Asn Leu Ile Cys Gly Phe 
            260                 265                 270         


Leu Arg Lys Ile Ala 
        275         


<210> 84
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> deoD (polypeptide)

<400> 84
Met Ala Thr Pro His Ile Asn Ala Glu Met Gly Asp Phe Ala Asp Val 
1               5                   10                  15      


Val Leu Met Pro Gly Asp Pro Leu Arg Ala Lys Tyr Ile Ala Glu Thr 
            20                  25                  30          


Phe Leu Glu Asp Ala Arg Glu Val Asn Asn Val Arg Gly Met Leu Gly 
        35                  40                  45              


Phe Thr Gly Thr Tyr Lys Gly Arg Lys Ile Ser Val Met Gly His Gly 
    50                  55                  60                  


Met Gly Ile Pro Ser Cys Ser Ile Tyr Thr Lys Glu Leu Ile Thr Asp 
65                  70                  75                  80  


Phe Gly Val Lys Lys Ile Ile Arg Val Gly Ser Cys Gly Ala Val Leu 
                85                  90                  95      


Pro His Val Lys Leu Arg Asp Val Val Ile Gly Met Gly Ala Cys Thr 
            100                 105                 110         


Asp Ser Lys Val Asn Arg Ile Arg Phe Lys Asp His Asp Phe Ala Ala 
        115                 120                 125             


Ile Ala Asp Phe Asp Met Val Arg Asn Ala Val Asp Ala Ala Lys Ala 
    130                 135                 140                 


Leu Gly Val Asp Ala Arg Val Gly Asn Leu Phe Ser Ala Asp Leu Phe 
145                 150                 155                 160 


Tyr Ser Pro Asp Gly Glu Met Phe Asp Val Met Glu Lys Tyr Gly Ile 
                165                 170                 175     


Leu Gly Val Glu Met Glu Ala Ala Gly Ile Tyr Gly Val Ala Ala Glu 
            180                 185                 190         


Phe Gly Ala Lys Ala Leu Thr Ile Cys Thr Val Ser Asp His Ile Arg 
        195                 200                 205             


Thr His Glu Gln Thr Thr Ala Ala Glu Arg Gln Thr Thr Phe Asn Asp 
    210                 215                 220                 


Met Ile Lys Ile Ala Leu Glu Ser Val Leu Leu Gly Asp Lys Glu 
225                 230                 235                 


<210> 85
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> argA WT

<400> 85
gcaaaaaaac agaataaaaa tacaataatt tcgaataatc atgcaaagag gtgtaccgtg       60


<210> 86
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> argA mutant

<400> 86
gcaaaaaaac actttaaaaa cttaataatt tcctttaatc acttaaagag gtgtaccgtg       60


<210> 87
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> argI WT

<400> 87
agacttgcaa atgaataatc atccatatag attgaatttt aattcattaa ggcgttagcc       60

acaggaggga tctatg                                                       76


<210> 88
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> argI mutant

<400> 88
agacttgcaa acttatactt atccatatag attttgtttt aatttgttaa ggcgttagcc       60

acaggaggga tctatg                                                       76


<210> 89
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argCBH WT

<400> 89
tcattgttga cacacctctg gtcatgatag tatcaatatt catgcagtat ttatgaataa       60

aaatacacta acgttgagcg taataaaacc caccagccgt aaggtgaatg ttttacgttt      120

aacctggcaa ccagacataa gaaggtgaat agccccgatg                            160


<210> 90
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argCBH mutant

<400> 90
tcattgttga cacacctctg gtcatgatag tatcaaactt catgggatat ttatctttaa       60

aaatacttga acgttgagcg taataaaacc caccagccgt aaggtgaatg ttttacgttt      120

aacctggcaa ccagacataa gaaggtgaat agccccgatg                            160


<210> 91
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argE WT

<400> 91
catcggggct attcaccttc ttatgtctgg ttgccaggtt aaacgtaaaa cattcacctt       60

acggctggtg ggttttatta cgctcaacgt tagtgtattt ttattcataa atactgcatg      120

aatattgata ctatcatgac cagaggtgtg tcaacaatga                            160


<210> 92
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argE mutant

<400> 92
catcggggct attcaccttc ttatgtctgg ttgccaggtt aaacgtaaaa cattcacctt       60

acggctggtg ggttttatta cgctcaacgt tcaagtattt ttaaagataa atatcccatg      120

aagtttgata ctatcatgac cagaggtgtg tcaacaatga                            160


<210> 93
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> carAB WT

<400> 93
agcagatttg cattgattta cgtcatcatt gtgaattaat atgcaaataa agtgagtgaa       60

tattctctgg agggtgtttt g                                                 81


<210> 94
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> carAB mutant

<400> 94
agcagatttg cattgattta cgtcatcatt gtcttttaat atcttaataa ctggagtgac       60

gtttctctgg agggtgtttt g                                                 81


<210> 95
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> argD WT

<400> 95
tttctgattg ccattcagtg attttttatg catattttgt gattataatt tcatatttat       60

ttatgcgtaa cagggtgatc atgagatg                                          88


<210> 96
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> argD mutant

<400> 96
tttctgattg ccattcagtc tttttttact tatattttgt ctttataatc ttatatttat       60

ttatgcgtaa cagggtgatc atgagatg                                          88


<210> 97
<211> 219
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argG WT

<400> 97
ctaatcacgt gaatgaatat ccagttcact ttcatttgtt gaatactttt accttctcct       60

gctttccctt aagcgcatta ttttacaaaa aacacactaa actcttcctg tctccgataa      120

aagatgatta aatgaaaact catttatttt gcataaaaat tcagtgaaag cagaaatcca      180

ggctcatcat cagttaatta agcagggtgt tattttatg                             219


<210> 98
<211> 219
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argG mutant

<400> 98
ctaatcacct taatgaatct tcagttcact ttcatttgtt gaatactttt accttctcct       60

gctttccctt aagcgcatta ttttacaaaa aacacactaa actcttcctg tctccgataa      120

aagatgatct tatgaaaacc tttttatttc ttataaaaat cttgtgaaag cagaaatcca      180

ggctcatcat cagttaatta agcagggtgt tattttatg                             219


<210> 99
<211> 233
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> argG mutant

<400> 99
cctgaaacgt ggcaaattct actcgttttg ggtaaaaaat gcaaatactg ctgggatttg       60

gtgtaccgag acgggacgta aaatctgcag gcattatagt gatccacgcc acattttgtc      120

aacgtttatt gctaatcatt gacggctagc tcagtcctag gtacagtgct agcacccgtt      180

tttttgggct agaaataatt ttgtttaact ttaagaagga gatatacata ccc             233


<210> 100
<211> 1053
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Wild-type argG

<400> 100
gtgatccacg ccacattttg tcaacgttta ttgctaatca cgtgaatgaa tatccagttc       60

actttcattt gttgaatact tttaccttct cctgctttcc cttaagcgca ttattttaca      120

aaaaacacac taaactcttc ctgtctccga taaaagatga ttaaatgaaa actcatttat      180

tttgcataaa aattcagtga aagcagaaat ccaggctcat catcagttaa ttaagcaggg      240

tgttatttta tgacgacgat tctcaagcat ctcccggtag gtcaacgtat tggtatcgct      300

ttttccggcg gtctggacac cagtgccgca ctgctgtgga tgcgacaaaa gggagcggtt      360

ccttatgcat atactgcaaa cctgggccag ccagacgaag aggattatga tgcgatccct      420

cgtcgtgcca tggaatacgg cgcggagaac gcacgtctga tcgactgccg caaacaactg      480

gtggccgaag gtattgccgc tattcagtgt ggcgcatttc ataacaccac tggtggactg      540

acctatttca acacgacgcc gctgggccgc gccgtgaccg gcaccatgct ggttgctgct      600

atgaaagaag atggcgtgaa tatctggggt gacggcagca cctataaagg aaacgatatc      660

gaacgtttct accgttacgg tctgctgacc aatgctgaac tgcagattta caaaccgtgg      720

cttgatactg actttattga tgaactgggt ggccgtcatg agatgtctga atttatgatt      780

gcctgcggtt tcgactacaa aatgtctgtc gaaaaagctt actccacgga ctccaacatg      840

cttggtgcaa cgcatgaagc gaaggatctg gaatacctca actccagcgt caaaatcgtc      900

aacccaatta tgggcgtgaa gttttgggat gagagcgtga aaatcccggc agaagaagtc      960

acagtacgct ttgagcaagg tcatccggtg gcgctgaacg gtaaaacctt tagcgacgac     1020

gtagaaatga tgctggaagc taaccgcatc ggc                                  1053


<210> 101
<211> 734
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Constitutive argG

<400> 101
ttgacggcta gctcagtcct aggtacagtg ctagcacccg tttttttggg ctagaaataa       60

ttttgtttaa ctttaagaag gagatataca tacccatgac gacgattctc aagcatctcc      120

cggtaggtca acgtattggt atcgcttttt ccggcggtct ggacaccagt gccgcactgc      180

tgtggatgcg acaaaaggga gcggttcctt atgcatatac tgcaaacctg ggccagccag      240

acgaagagga ttatgatgcg atccctcgtc gtgccatgga atacggcgcg gagaacgcac      300

gtctgatcga ctgccgcaaa caactggtgg ccgaaggtat tgccgctatt cagtgtggcg      360

catttcataa caccactggt ggactgacct atttcaacac gacgccgctg ggccgcgccg      420

tgaccggcac catgctggtt gctgctatga aagaagatgg cgtgaatatc tggggtgacg      480

gcagcaccta taaaggaaac gatatcgaac gtttctaccg ttacggtctg ctgaccaatg      540

ctgaactgca gatttacaaa ccgtggcttg atactgactt tattgatgaa ctgggtggcc      600

gtcatgagat gtctgaattt atgattgcct gcggtttcga ctacaaaatg tctgtcgaaa      660

aagcttactc cacggactcc aacatgcttg gtgcaacgca tgaagcgaag gatctggaat      720

acctcaactc cagc                                                        734


<210> 102
<211> 1332
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Nucleotide sequence of exemplary argAfbr sequence

<400> 102
atggtaaagg aacgtaaaac cgagttggtc gagggattcc gccattcggt tccctgtatc       60

aatacccacc ggggaaaaac gtttgtcatc atgctcggcg gtgaagccat tgagcatgag      120

aatttctcca gtatcgttaa tgatatcggg ttgttgcaca gcctcggcat ccgtctggtg      180

gtggtctatg gcgcacgtcc gcagatcgac gcaaatctgg ctgcgcatca ccacgaaccg      240

ctgtatcaca agaatatacg tgtgaccgac gccaaaacac tggaactggt gaagcaggct      300

gcgggaacat tgcaactgga tattactgct cgcctgtcga tgagtctcaa taacacgccg      360

ctgcagggcg cgcatatcaa cgtcgtcagt ggcaatttta ttattgccca gccgctgggc      420

gtcgatgacg gcgtggatta ctgccatagc gggcgtatcc ggcggattga tgaagacgcg      480

atccatcgtc aactggacag cggtgcaata gtgctaatgg ggccggtcgc tgtttcagtc      540

actggcgaga gctttaacct gacctcggaa gagattgcca ctcaactggc catcaaactg      600

aaagctgaaa agatgattgg tttttgctct tcccagggcg tcactaatga cgacggtgat      660

attgtctccg aacttttccc taacgaagcg caagcgcggg tagaagccca ggaagagaaa      720

ggcgattaca actccggtac ggtgcgcttt ttgcgtggcg cagtgaaagc ctgccgcagc      780

ggcgtgcgtc gctgtcattt aatcagttat caggaagatg gcgcgctgtt gcaagagttg      840

ttctcacgcg acggtatcgg tacgcagatt gtgatggaaa gcgccgagca gattcgtcgc      900

gcaacaatca acgatattgg cggtattctg gagttgattc gcccactgga gcagcaaggt      960

attctggtac gccgttctcg cgagcagctg gagatggaaa tcgacaaatt caccattatt     1020

cagcgcgata acacgactat tgcctgcgcc gcgctctatc cgttcccgga agagaagatt     1080

ggggaaatgg cctgtgtggc agttcacccg gattaccgca gttcatcaag gggtgaagtt     1140

ctgctggaac gcattgccgc tcaggctaag cagagcggct taagcaaatt gtttgtgctg     1200

accacgcgca gtattcactg gttccaggaa cgtggattta ccccagtgga tattgattta     1260

ctgcccgaga gcaaaaagca gttgtacaac taccagcgta aatccaaagt gttgatggcg     1320

gatttagggt aa                                                         1332


<210> 103
<211> 443
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Polypeptide sequence of exemplary argAfbr sequence

<400> 103
Met Val Lys Glu Arg Lys Thr Glu Leu Val Glu Gly Phe Arg His Ser 
1               5                   10                  15      


Val Pro Cys Ile Asn Thr His Arg Gly Lys Thr Phe Val Ile Met Leu 
            20                  25                  30          


Gly Gly Glu Ala Ile Glu His Glu Asn Phe Ser Ser Ile Val Asn Asp 
        35                  40                  45              


Ile Gly Leu Leu His Ser Leu Gly Ile Arg Leu Val Val Val Tyr Gly 
    50                  55                  60                  


Ala Arg Pro Gln Ile Asp Ala Asn Leu Ala Ala His His His Glu Pro 
65                  70                  75                  80  


Leu Tyr His Lys Asn Ile Arg Val Thr Asp Ala Lys Thr Leu Glu Leu 
                85                  90                  95      


Val Lys Gln Ala Ala Gly Thr Leu Gln Leu Asp Ile Thr Ala Arg Leu 
            100                 105                 110         


Ser Met Ser Leu Asn Asn Thr Pro Leu Gln Gly Ala His Ile Asn Val 
        115                 120                 125             


Val Ser Gly Asn Phe Ile Ile Ala Gln Pro Leu Gly Val Asp Asp Gly 
    130                 135                 140                 


Val Asp Tyr Cys His Ser Gly Arg Ile Arg Arg Ile Asp Glu Asp Ala 
145                 150                 155                 160 


Ile His Arg Gln Leu Asp Ser Gly Ala Ile Val Leu Met Gly Pro Val 
                165                 170                 175     


Ala Val Ser Val Thr Gly Glu Ser Phe Asn Leu Thr Ser Glu Glu Ile 
            180                 185                 190         


Ala Thr Gln Leu Ala Ile Lys Leu Lys Ala Glu Lys Met Ile Gly Phe 
        195                 200                 205             


Cys Ser Ser Gln Gly Val Thr Asn Asp Asp Gly Asp Ile Val Ser Glu 
    210                 215                 220                 


Leu Phe Pro Asn Glu Ala Gln Ala Arg Val Glu Ala Gln Glu Glu Lys 
225                 230                 235                 240 


Gly Asp Tyr Asn Ser Gly Thr Val Arg Phe Leu Arg Gly Ala Val Lys 
                245                 250                 255     


Ala Cys Arg Ser Gly Val Arg Arg Cys His Leu Ile Ser Tyr Gln Glu 
            260                 265                 270         


Asp Gly Ala Leu Leu Gln Glu Leu Phe Ser Arg Asp Gly Ile Gly Thr 
        275                 280                 285             


Gln Ile Val Met Glu Ser Ala Glu Gln Ile Arg Arg Ala Thr Ile Asn 
    290                 295                 300                 


Asp Ile Gly Gly Ile Leu Glu Leu Ile Arg Pro Leu Glu Gln Gln Gly 
305                 310                 315                 320 


Ile Leu Val Arg Arg Ser Arg Glu Gln Leu Glu Met Glu Ile Asp Lys 
                325                 330                 335     


Phe Thr Ile Ile Gln Arg Asp Asn Thr Thr Ile Ala Cys Ala Ala Leu 
            340                 345                 350         


Tyr Pro Phe Pro Glu Glu Lys Ile Gly Glu Met Ala Cys Val Ala Val 
        355                 360                 365             


His Pro Asp Tyr Arg Ser Ser Ser Arg Gly Glu Val Leu Leu Glu Arg 
    370                 375                 380                 


Ile Ala Ala Gln Ala Lys Gln Ser Gly Leu Ser Lys Leu Phe Val Leu 
385                 390                 395                 400 


Thr Thr Arg Ser Ile His Trp Phe Gln Glu Arg Gly Phe Thr Pro Val 
                405                 410                 415     


Asp Ile Asp Leu Leu Pro Glu Ser Lys Lys Gln Leu Tyr Asn Tyr Gln 
            420                 425                 430         


Arg Lys Ser Lys Val Leu Met Ala Asp Leu Gly 
        435                 440             


<210> 104
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> melittin

<400> 104
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Lys Gln Gln 
            20                  25      


<210> 105
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> LL-37

<400> 105
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 106
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> cecropin B

<400> 106
Lys Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      


Asn Gly Ile Val Lys Ala Gly Pro Ala Ile Ala Val Leu Gly Glu Ala 
            20                  25                  30          


Lys Ala Leu 
        35  


<210> 107
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Magainin 2

<400> 107
Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Glu Ile Met Asn Ser 
            20                  


<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EZH2

<400> 108
Phe Ile Asn Asp Glu Ile Phe Val Glu Leu 
1               5                   10  


<210> 109
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EZH2

<400> 109
Lys Tyr Asp Cys Phe Leu His Pro Phe 
1               5                   


<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EZH2

<400> 110
Lys Tyr Val Gly Ile Glu Arg Glu Met 
1               5                   


<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> glypican-3

<400> 111
Glu Tyr Ile Leu Ser Leu Glu Glu Leu 
1               5                   


<210> 112
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> consensus sequence

<400> 112
ttgttgayry rtcaacwa                                                     18


<210> 113
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> consensus sequence


<220>
<221> modified_base
<222> (8)..(8)
<223> a, c, g or t

<400> 113
ttataatnat tataa                                                        15


<210> 114
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> LacO

<400> 114
ggaattgtga gcgctcacaa tt                                                22


<210> 115
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> UP element helps recruit RNA polymerase

<400> 115
ggaaaatttt tttaaaaaaa aaac                                              24


<210> 116
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> RBS

<400> 116
ttatataaaa gtgggaggtg cccga                                             25


<210> 117
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 117
Lys Val Leu Glu Tyr Val Ile Lys Val 
1               5                   


<210> 118
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> May or may not be present

<400> 118
Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 119
Ile Leu Thr Val Ile Leu Gly Val Leu 
1               5                   


<210> 120
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1


<220>
<221> MISC_FEATURE
<222> (11)..(11)
<223> May or may not be present

<400> 120
Ala Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr 
1               5                   10      


<210> 121
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 121
Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser 
1               5                   10      


<210> 122
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 122
Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr Val Ile 
1               5                   10          


<210> 123
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SR34

<400> 123
cgcacactgg cgtcggctct ggcaggatgt ttcgtaatta gatagc                      46


<210> 124
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Bevacizumab (Avastin) anti-VEGF, Heavy Chain

<400> 124
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210> 125
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Bevacizumab (Avastin) anti-VEGF, Light Chain

<400> 125
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 126
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> D-peptide A

<400> 126
Arg Leu Tyr Leu Arg Ile Gly Arg Arg 
1               5                   


<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> D-peptide B

<400> 127
Arg Leu Arg Leu Arg Ile Gly Arg Arg 
1               5                   


<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> D-peptide C

<400> 128
Ala Leu Tyr Leu Ala Ile Arg Arg Arg 
1               5                   


<210> 129
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> D-peptide D

<400> 129
Arg Leu Leu Leu Arg Ile Gly Arg Arg 
1               5                   


<210> 130
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> D-K6L9

<400> 130
Leu Lys Leu Leu Lys Lys Leu Leu Lys Lys Leu Leu Lys Leu Leu 
1               5                   10                  15  


<210> 131
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NRC-03

<400> 131
Gly Arg Arg Lys Arg Lys Trp Leu Arg Arg Ile Gly Lys Gly Val Lys 
1               5                   10                  15      


Ile Ile Gly Gly Ala Ala Leu Asp His Leu 
            20                  25      


<210> 132
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NRC-07

<400> 132
Arg Trp Gly Lys Trp Phe Lys Lys Ala Thr His Val Gly Lys His Val 
1               5                   10                  15      


Gly Lys Ala Ala Leu Thr Ala Tyr Leu 
            20                  25  


<210> 133
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Gomesin

<400> 133
Glx Cys Arg Arg Leu Cys Tyr Lys Gln Arg Cys Val Thr Tyr Cys Arg 
1               5                   10                  15      


Gly Arg 
        


<210> 134
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Hepcidin TH2-3

<400> 134
Gln Ser His Leu Ser Leu Cys Arg Trp Cys Cys Asn Cys Cys Arg Ser 
1               5                   10                  15      


Asn Lys Gly Cys 
            20  


<210> 135
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Dermaseptin B2

<400> 135
Gly Leu Trp Ser Lys Ile Lys Glu Val Gly Lys Glu Ala Ala Lys Ala 
1               5                   10                  15      


Ala Ala Lys Ala Ala Gly Lys Ala Ala Leu Gly Ala Val Ser Glu Ala 
            20                  25                  30          


Val 
    


<210> 136
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PTP7

<400> 136
Phe Leu Gly Ala Leu Phe Lys Ala Leu Ser Lys Leu Leu 
1               5                   10              


<210> 137
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MGA2

<400> 137
Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser Gly Gly Lys Lys Trp Lys Met Arg Arg 
            20                  25                  30          


Asn Gln Phe Trp Val Lys Val Gln Arg Gly 
        35                  40          


<210> 138
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> HNP-1

<400> 138
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 139
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Tachyplesin

<400> 139
Lys Trp Cys Phe Arg Val Cys Tyr Arg Gly Ile Cys Tyr Arg Arg Cys 
1               5                   10                  15      


Arg 
    


<210> 140
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Temporin-1CEa

<400> 140
Phe Val Asp Leu Lys Lys Ile Ala Asn Ile Ile Asn Ser Ile Phe 
1               5                   10                  15  


<210> 141
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NK-2

<400> 141
Lys Ile Leu Arg Gly Val Cys Lys Lys Ile Met Arg Thr Phe Leu Arg 
1               5                   10                  15      


Arg Ile Ser Lys Asp Ile Leu Thr Gly Lys Lys 
            20                  25          


<210> 142
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Bovine lactoferricin B6 (Lbcin B6)

<400> 142
Arg Arg Trp Gln Trp Arg 
1               5       


<210> 143
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Cecropin CB1

<400> 143
Lys Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      


Asn Gly Ile Val Lys Ala Gly Pro Lys Trp Lys Val Phe Lys Lys Ile 
            20                  25                  30          


Glu Lys 
        


<210> 144
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melittin

<400> 144
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 145
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Tachyplesin

<400> 145
Lys Trp Cys Phe Arg Val Cys Tyr Arg Gly Ile Cys Tyr Arg Arg Cys 
1               5                   10                  15      


Arg 
    


<210> 146
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> LL-37

<400> 146
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 147
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Cecropin B

<400> 147
Lys Trp Lys Val Phe Lys Lys Ile Glu Lys Met Gly Arg Asn Ile Arg 
1               5                   10                  15      


Asn Gly Ile Val Lys Ala Gly Pro Ala Ile Ala Val Leu Gly Glu Ala 
            20                  25                  30          


Lys Ala Leu 
        35  


<210> 148
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Magainin 2

<400> 148
Gly Ile Gly Lys Phe Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210> 149
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Buforin IIb

<400> 149
Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Leu Leu Arg Arg Leu Leu 
1               5                   10                  15      


Arg Arg Leu Leu Arg 
            20      


<210> 150
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Alloferon-1

<400> 150
His Gly Val Ser Gly His Gly Gln His Gly Val His Gly 
1               5                   10              


<210> 151
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Alloferon-2

<400> 151
Gly Val Ser Gly His Gly Gln His Gly Val His Gly 
1               5                   10          


<210> 152
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-12 subunit alpha precursor (homo sapiens)

<400> 152
Met Trp Pro Pro Gly Ser Ala Ser Gln Pro Pro Pro Ser Pro Ala Ala 
1               5                   10                  15      


Ala Thr Gly Leu His Pro Ala Ala Arg Pro Val Ser Leu Gln Cys Arg 
            20                  25                  30          


Leu Ser Met Cys Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val 
        35                  40                  45              


Leu Leu Asp His Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro 
    50                  55                  60                  


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
65                  70                  75                  80  


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
                85                  90                  95      


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
            100                 105                 110         


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
        115                 120                 125             


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
    130                 135                 140                 


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
145                 150                 155                 160 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
                165                 170                 175     


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
            180                 185                 190         


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
        195                 200                 205             


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
    210                 215                 220                 


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
225                 230                 235                 240 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
                245                 250             


<210> 153
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-12 subunit beta precursor (homo sapiens)

<400> 153
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210> 154
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-15 isoform1 preproprotein (homo sapiens)

<400> 154
Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210> 155
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-15 isoform 2 preproprotein (homo sapiens)

<400> 155
Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210> 156
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-2 precursor (homo sapiens)

<400> 156
Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210> 157
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-21 isoform 1 precursor (homo sapiens)

<400> 157
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Met Ile His Gln His Leu Ser Ser Arg Thr His Gly Ser Glu 
145                 150                 155                 160 


Asp Ser 
        


<210> 158
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> interleukin-21 isoform 2 precursor (homo sapiens)

<400> 158
Met Arg Ser Ser Pro Gly Asn Met Glu Arg Ile Val Ile Cys Leu Met 
1               5                   10                  15      


Val Ile Phe Leu Gly Thr Leu Val His Lys Ser Ser Ser Gln Gly Gln 
            20                  25                  30          


Asp Arg His Met Ile Arg Met Arg Gln Leu Ile Asp Ile Val Asp Gln 
        35                  40                  45              


Leu Lys Asn Tyr Val Asn Asp Leu Val Pro Glu Phe Leu Pro Ala Pro 
    50                  55                  60                  


Glu Asp Val Glu Thr Asn Cys Glu Trp Ser Ala Phe Ser Cys Phe Gln 
65                  70                  75                  80  


Lys Ala Gln Leu Lys Ser Ala Asn Thr Gly Asn Asn Glu Arg Ile Ile 
                85                  90                  95      


Asn Val Ser Ile Lys Lys Leu Lys Arg Lys Pro Pro Ser Thr Asn Ala 
            100                 105                 110         


Gly Arg Arg Gln Lys His Arg Leu Thr Cys Pro Ser Cys Asp Ser Tyr 
        115                 120                 125             


Glu Lys Lys Pro Pro Lys Glu Phe Leu Glu Arg Phe Lys Ser Leu Leu 
    130                 135                 140                 


Gln Lys Val Ser Thr Leu Ser Phe Ile 
145                 150             


<210> 159
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> granulocyte-macrophage colony-stimulating factor
      precursor (homo sapiens)

<400> 159
Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> alpha-actinin-4

<400> 160
Phe Ile Ala Ser Asn Gly Val Lys Leu Val 
1               5                   10  


<210> 161
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> ARTC1

<400> 161
Tyr Ser Val Tyr Phe Asn Leu Pro Ala Asp Thr Ile Tyr Thr Asn His 
1               5                   10                  15      


<210> 162
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> BCR-ABL fusion protein (b3a2)

<400> 162
Ser Ser Lys Ala Leu Gln Arg Pro Val 
1               5                   


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> BCR-ABL fusion protein (b3a2)

<400> 163
Gly Phe Lys Gln Ser Ser Lys Ala Leu 
1               5                   


<210> 164
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> BCR-ABL fusion protein (b3a2)

<400> 164
Ala Thr Gly Phe Lys Gln Ser Ser Lys Ala Leu Gln Arg Pro Val Ala 
1               5                   10                  15      


Ser 
    


<210> 165
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> B-RAF

<400> 165
Glu Asp Leu Thr Val Lys Ile Gly Asp Phe Gly Leu Ala Thr Glu Lys 
1               5                   10                  15      


Ser Arg Trp Ser Gly Ser His Gln Phe Glu Gln Leu Ser 
            20                  25                  


<210> 166
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CASP-5

<400> 166
Phe Leu Ile Ile Trp Gln Asn Thr Met Gly 
1               5                   10  


<210> 167
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CASP-8

<400> 167
Phe Pro Ser Asp Ser Trp Cys Tyr Phe 
1               5                   


<210> 168
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> beta-catenin

<400> 168
Ser Tyr Leu Asp Ser Gly Ile His Phe 
1               5                   


<210> 169
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Cdc27

<400> 169
Phe Ser Trp Ala Met Asp Leu Asp Pro Lys Gly Ala Glu 
1               5                   10              


<210> 170
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CDK4

<400> 170
Ala Cys Asp Pro His Ser Gly His Phe Val 
1               5                   10  


<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CDK12

<400> 171
Cys Ile Leu Gly Lys Leu Phe Thr Lys 
1               5                   


<210> 172
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CDKN2A

<400> 172
Ala Val Cys Pro Trp Thr Trp Leu Arg Gly 
1               5                   10  


<210> 173
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CLPP

<400> 173
Ile Leu Asp Lys Val Leu Val His Leu 
1               5                   


<210> 174
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> COA-1

<400> 174
Thr Leu Tyr Gln Asp Asp Thr Leu Thr Leu Gln Ala Ala Gly Glu 
1               5                   10                  15  


<210> 175
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CSNK1A1

<400> 175
Gly Leu Phe Gly Asp Ile Tyr Leu Ala 
1               5                   


<210> 176
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> dek-can fusion protein

<400> 176
Thr Met Lys Gln Ile Cys Lys Lys Glu Ile Arg Arg Leu His Gln Tyr 
1               5                   10                  15      


<210> 177
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EFTUD2

<400> 177
Lys Ile Leu Asp Ala Val Val Ala Gln Lys 
1               5                   10  


<210> 178
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Elongation factor 2

<400> 178
Glu Thr Val Ser Glu Gln Ser Asn Val 
1               5                   


<210> 179
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> ETV6-AML1 fusion protein

<400> 179
Arg Ile Ala Glu Cys Ile Leu Gly Met Ile 
1               5                   10  


<210> 180
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> ETV6-AML1 fusion protein

<400> 180
Ile Gly Arg Ile Ala Glu Cys Ile Leu Gly Met Asn Pro Ser Arg 
1               5                   10                  15  


<210> 181
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> FLT3-ITD

<400> 181
Tyr Val Asp Phe Arg Glu Tyr Glu Tyr Tyr 
1               5                   10  


<210> 182
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> FNDC3B

<400> 182
Val Val Met Ser Trp Ala Pro Pro Val 
1               5                   


<210> 183
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> FN1

<400> 183
Met Ile Phe Glu Lys His Gly Phe Arg Arg Thr Thr Pro Pro 
1               5                   10                  


<210> 184
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> GAS7

<400> 184
Ser Leu Ala Asp Glu Ala Glu Val Tyr Leu 
1               5                   10  


<210> 185
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> GPNMB

<400> 185
Thr Leu Asp Trp Leu Leu Gln Thr Pro Lys 
1               5                   10  


<210> 186
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HAUS3

<400> 186
Ile Leu Asn Ala Met Ile Ala Lys Ile 
1               5                   


<210> 187
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HSDL1

<400> 187
Cys Tyr Met Glu Ala Val Ala Leu 
1               5               


<210> 188
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LDLR-fucosyltransferaseAS

<400> 188
Trp Arg Arg Ala Pro Ala Pro Gly Ala 
1               5                   


<210> 189
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> fusion protein

<400> 189
Pro Val Thr Trp Arg Arg Ala Pro Ala 
1               5                   


<210> 190

<400> 190
000


<210> 191

<400> 191
000


<210> 192
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> hsp70-2

<400> 192
Ser Leu Phe Glu Gly Ile Asp Ile Tyr Thr 
1               5                   10  


<210> 193
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> hsp70-2

<400> 193
Ala Glu Pro Ile Asn Ile Gln Thr Trp 
1               5                   


<210> 194
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MART2

<400> 194
Phe Leu Glu Gly Asn Glu Val Gly Lys Thr Tyr 
1               5                   10      


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MATN

<400> 195
Lys Thr Leu Thr Ser Val Phe Gln Lys 
1               5                   


<210> 196
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> ME1

<400> 196
Phe Leu Asp Glu Phe Met Glu Gly Val 
1               5                   


<210> 197
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUM-1f

<400> 197
Glu Glu Lys Leu Ile Val Val Leu Phe 
1               5                   


<210> 198
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUM-2

<400> 198
Ser Glu Leu Phe Arg Ser Gly Leu Asp Ser Tyr 
1               5                   10      


<210> 199
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUM-2

<400> 199
Phe Arg Ser Gly Leu Asp Ser Tyr Val 
1               5                   


<210> 200
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUM-3

<400> 200
Glu Ala Phe Ile Gln Pro Ile Thr Arg 
1               5                   


<210> 201
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> neo-PAP

<400> 201
Arg Val Ile Lys Asn Ser Ile Arg Leu Thr Leu Glu 
1               5                   10          


<210> 202
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Myosin class I

<400> 202
Lys Ile Asn Lys Asn Pro Lys Tyr Lys 
1               5                   


<210> 203
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NFYC

<400> 203
Gln Gln Ile Thr Lys Thr Glu Val 
1               5               


<210> 204
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> OGT

<400> 204
Ser Leu Tyr Lys Phe Ser Pro Phe Pro Leu Gly 
1               5                   10      


<210> 205
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> OS-9

<400> 205
Lys Glu Leu Glu Gly Ile Leu Leu Leu 
1               5                   


<210> 206
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> p53

<400> 206
Val Val Pro Cys Glu Pro Pro Glu Val 
1               5                   


<210> 207
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> pml-RARalpha fusion protein

<400> 207
Asn Ser Asn His Val Ala Ser Gly Ala Gly Glu Ala Ala Ile Glu Thr 
1               5                   10                  15      


Gln Ser Ser Ser Ser Glu Glu Ile Val 
            20                  25  


<210> 208
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PPP1R3B

<400> 208
Tyr Thr Asp Phe His Cys Gln Tyr Val 
1               5                   


<210> 209
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PRDX5

<400> 209
Leu Leu Leu Asp Asp Leu Leu Val Ser Ile 
1               5                   10  


<210> 210
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PTPRK

<400> 210
Pro Tyr Tyr Phe Ala Ala Glu Leu Pro Pro Arg Asn Leu Pro Glu Pro 
1               5                   10                  15      


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> K-ras

<400> 211
Val Val Val Gly Ala Val Gly Val Gly 
1               5                   


<210> 212
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> N-ras

<400> 212
Ile Leu Asp Thr Ala Gly Arg Glu Glu Tyr 
1               5                   10  


<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RBAF600

<400> 213
Arg Pro His Val Pro Glu Ser Ala Phe 
1               5                   


<210> 214
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SIRT2

<400> 214
Lys Ile Phe Ser Glu Val Thr Leu Lys 
1               5                   


<210> 215
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SNRPD1

<400> 215
Ser His Glu Thr Val Ile Ile Glu Leu 
1               5                   


<210> 216
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SYT-SSX1 or -SSX2 fusion protein

<400> 216
Gln Arg Pro Tyr Gly Tyr Asp Gln Ile Met 
1               5                   10  


<210> 217
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TGF-betaRII

<400> 217
Arg Leu Ser Ser Cys Val Pro Val Ala Gly 
1               5                   10  


<210> 218
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Triosephosphate isomerase

<400> 218
Gly Glu Leu Ile Gly Ile Leu Asn Ala Ala Lys Val Pro Ala Asp 
1               5                   10                  15  


<210> 219
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Cyclin-A1

<400> 219
Phe Leu Asp Arg Phe Leu Ser Cys Met 
1               5                   


<210> 220
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Cyclin-A1

<400> 220
Ser Leu Ile Ala Ala Ala Ala Phe Cys Leu Ala 
1               5                   10      


<210> 221
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> GAGE-1,2,8

<400> 221
Tyr Arg Pro Arg Pro Arg Arg Tyr 
1               5               


<210> 222
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> GAGE-3,4,5,6,7

<400> 222
Tyr Tyr Trp Pro Arg Pro Arg Arg Tyr 
1               5                   


<210> 223
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> GnTVf


<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> May or may not be present

<400> 223
Val Leu Pro Asp Val Phe Ile Arg Cys Val 
1               5                   10  


<210> 224
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HERV-K-MEL

<400> 224
Met Leu Ala Val Ile Ser Cys Ala Val 
1               5                   


<210> 225
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KK-LC-1

<400> 225
Arg Gln Lys Arg Ile Leu Val Asn Leu 
1               5                   


<210> 226
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KM-HN-1

<400> 226
Asn Tyr Asn Asn Phe Tyr Arg Phe Leu 
1               5                   


<210> 227
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KM-HN-1

<400> 227
Glu Tyr Ser Lys Glu Cys Leu Lys Glu Phe 
1               5                   10  


<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KM-HN-1

<400> 228
Glu Tyr Leu Ser Leu Ser Asp Lys Ile 
1               5                   


<210> 229
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 229
Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu 
1               5                   10      


<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 230
Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210> 231
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 231
Leu Ala Ala Gln Glu Arg Arg Val Pro Arg 
1               5                   10  


<210> 232
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 232
Glu Leu Val Arg Arg Ile Leu Ser Arg 
1               5                   


<210> 233
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 233
Ala Pro Arg Gly Val Arg Met Ala Val 
1               5                   


<210> 234
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 234
Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe 
1               5                   10                  


<210> 235
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 235
Gln Gly Ala Met Leu Ala Ala Gln Glu Arg Arg Val Pro Arg Ala Ala 
1               5                   10                  15      


Glu Val Pro Arg 
            20  


<210> 236
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 236
Ala Ala Asp His Arg Gln Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln 
1               5                   10                  15      


Gln Leu 
        


<210> 237
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 237
Cys Leu Ser Arg Arg Pro Trp Lys Arg Ser Trp Ser Ala Gly Ser Cys 
1               5                   10                  15      


Pro Gly Met Pro His Leu 
            20          


<210> 238
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 238
Ile Leu Ser Arg Asp Ala Ala Pro Leu Pro Arg Pro Gly 
1               5                   10              


<210> 239
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LAGE-1

<400> 239
Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala Gly Ala 
1               5                   10                  


<210> 240
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LY6K

<400> 240
Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile 
1               5                   10  


<210> 241
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LY6K

<400> 241
Lys Trp Thr Glu Pro Tyr Cys Val Ile Ala Ala Val Lys Ile Phe Pro 
1               5                   10                  15      


Arg Phe Phe Met Val Ala Lys Gln 
            20                  


<210> 242
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> LY6K

<400> 242
Lys Cys Cys Lys Ile Arg Tyr Cys Asn Leu Glu Gly Pro Pro Ile Asn 
1               5                   10                  15      


Ser Ser Val Phe 
            20  


<210> 243
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 243
Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210> 244
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 244
Ser Leu Phe Arg Ala Val Ile Thr Lys 
1               5                   


<210> 245
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 245
Glu Val Tyr Asp Gly Arg Glu His Ser Ala 
1               5                   10  


<210> 246
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 246
Arg Val Arg Phe Phe Phe Pro Ser Leu 
1               5                   


<210> 247
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 247
Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210> 248
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 248
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 249
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 249
Lys Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   10  


<210> 250
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 250
Asp Pro Ala Arg Tyr Glu Phe Leu Trp 
1               5                   


<210> 251
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 251
Ile Thr Lys Lys Val Ala Asp Leu Val Gly Phe 
1               5                   10      


<210> 252
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 252
Ser Ala Phe Pro Thr Thr Ile Asn Phe 
1               5                   


<210> 253
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 253
Ser Ala Tyr Gly Glu Pro Arg Lys Leu 
1               5                   


<210> 254
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 254
Arg Val Arg Phe Phe Phe Pro Ser Leu 
1               5                   


<210> 255
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 255
Ser Ala Tyr Gly Glu Pro Arg Lys Leu 
1               5                   


<210> 256
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 256
Thr Ser Cys Ile Leu Glu Ser Leu Phe Arg Ala Val Ile Thr Lys 
1               5                   10                  15  


<210> 257
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 257
Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu Glu Tyr 
1               5                   10                  15  


<210> 258
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 258
Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  15      


<210> 259
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A1

<400> 259
Glu Tyr Val Ile Lys Val Ser Ala Arg Val Arg Phe 
1               5                   10          


<210> 260
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A2

<400> 260
Tyr Leu Gln Leu Val Phe Gly Ile Glu Val 
1               5                   10  


<210> 261
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A2

<400> 261
Glu Tyr Leu Gln Leu Val Phe Gly Ile 
1               5                   


<210> 262
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A2

<400> 262
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 263
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A2

<400> 263
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 264
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A2

<400> 264
Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  


<210> 265
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 265
Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210> 266
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 266
Phe Leu Trp Gly Pro Arg Ala Leu Val Asp 
1               5                   10  


<210> 267
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 267
Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210> 268
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 268
Thr Phe Pro Asp Leu Glu Ser Glu Phe 
1               5                   


<210> 269
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 269
Val Ala Glu Leu Val His Phe Leu Leu 
1               5                   


<210> 270
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 270
Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210> 271
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 271
Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210> 272
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 272
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 273
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 273
Ala Glu Leu Val His Phe Leu Leu Leu Ile 
1               5                   10  


<210> 274
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 274
Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210> 275
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 275
Trp Gln Tyr Phe Phe Pro Val Ile Phe 
1               5                   


<210> 276
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 276
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 277
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 277
Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210> 278
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 278
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210> 279
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 279
Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210> 280
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 280
Ala Cys Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Val Glu Thr Ser 
1               5                   10                  15      


<210> 281
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 281
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210> 282
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 282
Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
1               5                   10          


<210> 283
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 283
Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu 
1               5                   10                  15  


<210> 284
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 284
Gly Asp Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val 
1               5                   10                  15  


<210> 285
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 285
Thr Ser Tyr Val Lys Val Leu His His Met Val Lys Ile Ser Gly 
1               5                   10                  15  


<210> 286
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 286
Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala 
1               5                   10                  15      


<210> 287
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A3

<400> 287
Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  15      


<210> 288
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A4

<400> 288
Glu Val Asp Pro Ala Ser Asn Thr Tyr 
1               5                   


<210> 289
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A4

<400> 289
Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210> 290
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A4

<400> 290
Asn Tyr Lys Arg Cys Phe Pro Val Ile 
1               5                   


<210> 291
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A4

<400> 291
Ser Glu Ser Leu Lys Met Ile Phe 
1               5               


<210> 292
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A6

<400> 292
Met Val Lys Ile Ser Gly Gly Pro Arg 
1               5                   


<210> 293
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A6

<400> 293
Glu Val Asp Pro Ile Gly His Val Tyr 
1               5                   


<210> 294
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A6

<400> 294
Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210> 295
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A6

<400> 295
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 296
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A6

<400> 296
Ile Ser Gly Gly Pro Arg Ile Ser Tyr 
1               5                   


<210> 297
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A6

<400> 297
Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  


<210> 298
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A9

<400> 298
Ala Leu Ser Val Met Gly Val Tyr Val 
1               5                   


<210> 299
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A10

<400> 299
Gly Leu Tyr Asp Gly Met Glu His Leu Leu 
1               5                   10  


<210> 300
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A10

<400> 300
Asp Pro Ala Arg Tyr Glu Phe Leu Trp 
1               5                   


<210> 301
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A12 m

<400> 301
Phe Leu Trp Gly Pro Arg Ala Leu Val Glu 
1               5                   10  


<210> 302
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A12 m

<400> 302
Val Arg Ile Gly His Leu Tyr Ile Leu 
1               5                   


<210> 303
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A12 m

<400> 303
Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210> 304
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A12 m

<400> 304
Arg Glu Pro Phe Thr Lys Ala Glu Met Leu Gly Ser Val Ile Arg 
1               5                   10                  15  


<210> 305
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-A12 m

<400> 305
Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg 
1               5                   10                  


<210> 306
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C1

<400> 306
Ile Leu Phe Gly Ile Ser Leu Arg Glu Val 
1               5                   10  


<210> 307
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C1

<400> 307
Lys Val Val Glu Phe Leu Ala Met Leu 
1               5                   


<210> 308
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C1

<400> 308
Ser Ser Ala Leu Leu Ser Ile Phe Gln Ser Ser Pro Glu 
1               5                   10              


<210> 309
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C1

<400> 309
Ser Phe Ser Tyr Thr Leu Leu Ser Leu 
1               5                   


<210> 310
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C1

<400> 310
Val Ser Ser Phe Phe Ser Tyr Thr Leu 
1               5                   


<210> 311
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C2

<400> 311
Leu Leu Phe Gly Leu Ala Leu Ile Glu Val 
1               5                   10  


<210> 312
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C2

<400> 312
Ala Leu Lys Asp Val Glu Glu Arg Val 
1               5                   


<210> 313
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C2

<400> 313
Ser Glu Ser Ile Lys Lys Lys Val Leu 
1               5                   


<210> 314
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C2

<400> 314
Ala Ser Ser Thr Leu Tyr Leu Val Phe 
1               5                   


<210> 315
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MAGE-C2

<400> 315
Ser Ser Thr Leu Tyr Leu Val Phe Ser Pro Ser Ser Phe Ser Thr 
1               5                   10                  15  


<210> 316
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> mucink

<400> 316
Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly 
1               5                   10                  15      


Val Thr Ser Ala 
            20  


<210> 317
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NA88-A

<400> 317
Gln Gly Gln His Phe Leu Gln Lys Val 
1               5                   


<210> 318
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 318
Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210> 319
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 319
Met Leu Met Ala Gln Glu Ala Leu Ala Phe Leu 
1               5                   10      


<210> 320
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 320
Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu 
1               5                   10      


<210> 321
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 321
Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg 
1               5                   10  


<210> 322
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 322
Leu Ala Ala Gln Glu Arg Arg Val Pro Arg 
1               5                   10  


<210> 323
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 323
Thr Val Ser Gly Asn Ile Leu Thr Ile Arg 
1               5                   10  


<210> 324
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 324
Ala Pro Arg Gly Pro His Gly Gly Ala Ala Ser Gly Leu 
1               5                   10              


<210> 325
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 325
Met Pro Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   10      


<210> 326
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 326
Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr Ile 
1               5                   10          


<210> 327
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 327
Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   


<210> 328
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 328
Phe Ala Thr Pro Met Glu Ala Glu Leu 
1               5                   


<210> 329
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 329
Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg 
1               5                   10      


<210> 330
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 330
Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   


<210> 331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 331
Ala Arg Gly Pro Glu Ser Arg Leu Leu 
1               5                   


<210> 332
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 332
Ser Leu Leu Met Trp Ile Thr Gln Cys Phe Leu Pro Val Phe 
1               5                   10                  


<210> 333
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 333
Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   10                  15      


Glu Leu Ala Arg Arg Ser Leu Ala Gln 
            20                  25  


<210> 334
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 334
Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   10          


<210> 335
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 335
Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10                  15      


Ile Arg Leu Thr Ala Ala Asp His Arg 
            20                  25  


<210> 336
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 336
Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala 
1               5                   10          


<210> 337
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 337
Gln Gly Ala Met Leu Ala Ala Gln Glu Arg Arg Val Pro Arg Ala Ala 
1               5                   10                  15      


Glu Val Pro Arg 
            20  


<210> 338
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 338
Pro Phe Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg 
1               5                   10              


<210> 339
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 339
Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10                  15      


Ile Arg Leu Thr 
            20  


<210> 340
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 340
Val Leu Leu Lys Glu Phe Thr Val Ser Gly 
1               5                   10  


<210> 341
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 341
Ala Ala Asp His Arg Gln Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln 
1               5                   10                  15      


Gln Leu 
        


<210> 342
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 342
Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met Glu Ala 
1               5                   10                  15      


Glu Leu Ala Arg Arg Ser Leu Ala Gln 
            20                  25  


<210> 343
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 343
Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr Ile Arg Leu 
1               5                   10                  15  


<210> 344
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 344
Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10                  15      


Ile Arg Leu Thr Ala Ala Asp His Arg 
            20                  25  


<210> 345
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 345
Lys Glu Phe Thr Val Ser Gly Asn Ile Leu Thr 
1               5                   10      


<210> 346
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 346
Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala Thr Pro Met 
1               5                   10                  


<210> 347
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-ESO-1 / LAGE-2

<400> 347
Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala Gly Ala 
1               5                   10                  


<210> 348
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SAGE

<400> 348
Leu Tyr Ala Thr Val Ile His Asp Ile 
1               5                   


<210> 349
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Sp17

<400> 349
Ile Leu Asp Ser Ser Glu Glu Asp Lys 
1               5                   


<210> 350
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-2

<400> 350
Lys Ala Ser Glu Lys Ile Phe Tyr Val 
1               5                   


<210> 351
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-2

<400> 351
Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe Ser Lys 
1               5                   10                  15      


<210> 352
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-2

<400> 352
Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile 
1               5                   10      


<210> 353
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-2

<400> 353
Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr Val Tyr Met Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 354
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-2

<400> 354
Lys Ile Phe Tyr Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr 
1               5                   10                  15  


<210> 355
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-2

<400> 355
Lys Ile Phe Tyr Val Tyr Met Lys Arg Lys Tyr Glu Ala Met 
1               5                   10                  


<210> 356
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 356
Ile Asn Lys Thr Ser Gly Pro Lys Arg Gly Lys His Ala Trp Thr His 
1               5                   10                  15      


Arg Leu Arg Glu 
            20  


<210> 357
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 357
Tyr Phe Ser Lys Lys Glu Trp Glu Lys Met Lys Ser Ser Glu Lys Ile 
1               5                   10                  15      


Val Tyr Val Tyr 
            20  


<210> 358
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 358
Met Lys Leu Asn Tyr Glu Val Met Thr Lys Leu Gly Phe Lys Val Thr 
1               5                   10                  15      


Leu Pro Pro Phe 
            20  


<210> 359
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 359
Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
1               5                   10                  15      


Tyr Glu Glu Ile 
            20  


<210> 360
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 360
Leu Gly Phe Lys Val Thr Leu Pro Pro Phe Met Arg Ser Lys Arg Ala 
1               5                   10                  15      


Ala Asp Phe His 
            20  


<210> 361
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 361
Lys Ser Ser Glu Lys Ile Val Tyr Val Tyr Met Lys Leu Asn Tyr Glu 
1               5                   10                  15      


Val Met Thr Lys 
            20  


<210> 362
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SSX-4

<400> 362
Lys His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Val 
1               5                   10                  15      


Tyr Glu Glu Ile 
            20  


<210> 363
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TAG-1

<400> 363
Ser Leu Gly Trp Leu Phe Leu Leu Leu 
1               5                   


<210> 364
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TAG-1

<400> 364
Leu Ser Arg Leu Ser Asn Arg Leu Leu 
1               5                   


<210> 365
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRAG-3

<400> 365
Cys Glu Phe His Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
1               5                   10                  15  


<210> 366
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRAG-3

<400> 366
Cys Glu Phe His Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu 
1               5                   10                  15  


<210> 367
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP2-INT2g

<400> 367
Glu Val Ile Ser Cys Lys Leu Ile Lys Arg 
1               5                   10  


<210> 368
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> XAGE-1b/GAGED2a

<400> 368
Arg Gln Lys Lys Ile Arg Ile Gln Leu 
1               5                   


<210> 369
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> XAGE-1b/GAGED2a

<400> 369
His Leu Gly Ser Arg Gln Lys Lys Ile Arg Ile Gln Leu Arg Ser Gln 
1               5                   10                  15      


<210> 370
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> XAGE-1b/GAGED2a

<400> 370
Cys Ala Thr Trp Lys Val Ile Cys Lys Ser Cys Ile Ser Gln Thr Pro 
1               5                   10                  15      


Gly 
    


<210> 371
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 371
Tyr Leu Ser Gly Ala Asn Leu Asn Leu Gly 
1               5                   10  


<210> 372
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 372
Ile Met Ile Gly Val Leu Val Gly Val 
1               5                   


<210> 373
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 373
Gly Val Leu Val Gly Val Ala Leu Ile 
1               5                   


<210> 374
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 374
His Leu Phe Gly Tyr Ser Trp Tyr Lys 
1               5                   


<210> 375
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 375
Gln Tyr Ser Trp Phe Val Asn Gly Thr Phe 
1               5                   10  


<210> 376
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 376
Thr Tyr Ala Cys Phe Val Ser Asn Leu 
1               5                   


<210> 377
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 377
Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser Ala Asn Arg Ser 
1               5                   10                  15  


<210> 378
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 378
Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val Asn 
1               5                   10                  15      


Glu Glu Ala Thr Gly Gln Phe Arg Val 
            20                  25  


<210> 379
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 379
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val 
1               5                   10                  15  


<210> 380
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 380
Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys 
1               5                   10              


<210> 381
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 381
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn 
1               5                   10              


<210> 382
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 382
Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser 
1               5                   10                  15  


<210> 383
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 383
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro 
1               5                   10              


<210> 384
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 384
Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn 
1               5                   10              


<210> 385
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CEA

<400> 385
Asn Ser Ile Val Lys Ser Ile Thr Val Ser Ala Ser Gly 
1               5                   10              


<210> 386
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 386
Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210> 387
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> May or may not be present

<400> 387
Ala Met Leu Gly Thr His Thr Met Glu Val 
1               5                   10  


<210> 388
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 388
Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210> 389
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 389
Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210> 390
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 390
Leu Leu Asp Gly Thr Ala Thr Leu Arg Leu 
1               5                   10  


<210> 391
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 391
Val Leu Tyr Arg Tyr Gly Ser Phe Ser Val 
1               5                   10  


<210> 392
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 392
Ser Leu Ala Asp Thr Asn Ser Leu Ala Val 
1               5                   10  


<210> 393
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 393
Arg Leu Met Lys Gln Asp Phe Ser Val 
1               5                   


<210> 394
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 394
Arg Leu Pro Arg Ile Phe Cys Ser Cys 
1               5                   


<210> 395
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 395
Leu Ile Tyr Arg Arg Arg Leu Met Lys 
1               5                   


<210> 396
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 396
Ala Leu Leu Ala Val Gly Ala Thr Lys 
1               5                   


<210> 397
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 397
Ile Ala Leu Asn Phe Pro Gly Ser Gln Lys 
1               5                   10  


<210> 398
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 398
Arg Ser Tyr Val Pro Leu Ala His Arg 
1               5                   


<210> 399
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 399
Ala Leu Asn Phe Pro Gly Ser Gln Lys 
1               5                   


<210> 400
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 400
Val Tyr Phe Phe Leu Pro Asp His Leu 
1               5                   


<210> 401
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 401
Arg Thr Lys Gln Leu Tyr Pro Glu Trp 
1               5                   


<210> 402
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 402
His Thr Met Glu Val Thr Val Tyr His Arg 
1               5                   10  


<210> 403
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 403
Ser Ser Pro Gly Cys Gln Pro Pro Ala 
1               5                   


<210> 404
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 404
Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
1               5                   10  


<210> 405
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 405
Leu Pro His Ser Ser Ser His Trp Leu 
1               5                   


<210> 406
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 406
Ser Asn Asp Gly Pro Thr Leu Ile 
1               5               


<210> 407
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 407
Gly Arg Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr 
1               5                   10                  15  


<210> 408
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 408
Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp 
1               5                   10                  15      


<210> 409
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 409
Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro Ile Pro Glu 
1               5                   10                  15      


Pro Glu 
        


<210> 410
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> gp100 / Pmel17

<400> 410
Thr Gly Arg Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val Tyr 
1               5                   10                  15      


His 
    


<210> 411
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> mammaglobin-A

<400> 411
Pro Leu Leu Glu Asn Val Ile Ser Lys 
1               5                   


<210> 412
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Melan-A / MART-1

<400> 412
Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile Leu Thr Val Ile 
1               5                   10                  15      


Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys Arg Arg 
            20                  25                  30  


<210> 413
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 413
Ala Ala Gly Ile Gly Ile Leu Thr Val Ile Leu Gly Val Leu 
1               5                   10                  


<210> 414
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 414
Ala Pro Pro Ala Tyr Glu Lys Leu Pro Ser Ala Glu Gln Phe 
1               5                   10                  


<210> 415
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 415
Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val Gly Thr 
1               5                   10                  15      


Gln Cys Ala Leu Thr Arg Arg 
            20              


<210> 416
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 416
Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser 
            20  


<210> 417
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Melan-A / MART-1

<400> 417
Lys Asn Cys Glu Pro Val Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys 
1               5                   10                  15      


Leu Ser Ala Glu 
            20  


<210> 418
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> NY-BR-1

<400> 418
Ser Leu Ser Lys Ile Leu Asp Thr Val 
1               5                   


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> OA1

<400> 419
Leu Tyr Ser Ala Cys Phe Trp Trp Leu 
1               5                   


<210> 420
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PAP

<400> 420
Phe Leu Phe Leu Leu Phe Phe Trp Leu 
1               5                   


<210> 421
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PAP

<400> 421
Thr Leu Met Ser Ala Met Thr Asn Leu 
1               5                   


<210> 422
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PAP

<400> 422
Ala Leu Asp Val Tyr Asn Gly Leu Leu 
1               5                   


<210> 423
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PSA

<400> 423
Phe Leu Thr Pro Lys Lys Leu Gln Cys Val 
1               5                   10  


<210> 424
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PSA

<400> 424
Val Ile Ser Asn Asp Val Cys Ala Gln Val 
1               5                   10  


<210> 425
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RAB38 / NY-MEL-1

<400> 425
Val Leu His Trp Asp Pro Glu Thr Val 
1               5                   


<210> 426
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-1 / gp75

<400> 426
Met Ser Leu Gln Arg Gln Phe Leu Arg 
1               5                   


<210> 427
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-1 / gp75

<400> 427
Ile Ser Pro Asn Ser Val Phe Ser Gln Trp Arg Val Val Cys Asp Ser 
1               5                   10                  15      


Leu Glu Asp Tyr Asp 
            20      


<210> 428
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-1 / gp75

<400> 428
Ser Leu Pro Tyr Trp Asn Phe Ala Thr Gly 
1               5                   10  


<210> 429
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-1 / gp75

<400> 429
Ser Gln Trp Arg Val Val Cys Asp Ser Leu Glu Asp Tyr Asp Thr 
1               5                   10                  15  


<210> 430
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-2

<400> 430
Ser Val Tyr Asp Phe Phe Val Trp Leu 
1               5                   


<210> 431
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-2

<400> 431
Thr Leu Asp Ser Gln Val Met Ser Leu 
1               5                   


<210> 432
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-2

<400> 432
Leu Leu Gly Pro Gly Arg Pro Tyr Arg 
1               5                   


<210> 433
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-2

<400> 433
Ala Asn Asp Pro Ile Phe Val Val Leu 
1               5                   


<210> 434
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-2

<400> 434
Gln Cys Thr Glu Val Arg Ala Asp Thr Arg Pro Trp Ser Gly Pro 
1               5                   10                  15  


<210> 435
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TRP-2

<400> 435
Ala Leu Pro Tyr Trp Asn Phe Ala Thr Gly 
1               5                   10  


<210> 436
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 436
Lys Cys Asp Ile Cys Thr Asp Glu Tyr 
1               5                   


<210> 437
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 437
Ser Ser Asp Tyr Val Ile Pro Ile Gly Thr Tyr 
1               5                   10      


<210> 438
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 438
Met Leu Leu Ala Val Leu Tyr Cys Leu 
1               5                   


<210> 439
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 439
Cys Leu Leu Trp Ser Phe Gln Thr Ser Ala 
1               5                   10  


<210> 440
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 440
Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210> 441
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 441
Ala Phe Leu Pro Trp His Arg Leu Phe 
1               5                   


<210> 442
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 442
Ile Tyr Met Asp Gly Thr Ala Asp Phe Ser Phe 
1               5                   10      


<210> 443
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 443
Gln Cys Ser Gly Asn Phe Met Gly Phe 
1               5                   


<210> 444
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 444
Thr Pro Arg Leu Pro Ser Ser Ala Asp Val Glu Phe 
1               5                   10          


<210> 445
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 445
Leu Pro Ser Ser Ala Asp Val Glu Phe 
1               5                   


<210> 446
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 446
Leu His His Ala Phe Val Asp Ser Ile Phe 
1               5                   10  


<210> 447
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 447
Ser Glu Ile Trp Arg Asp Ile Asp Phe Asp 
1               5                   10  


<210> 448
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 448
Gln Asn Ile Leu Leu Ser Asn Ala Pro Leu Gly Pro Gln Phe Pro 
1               5                   10                  15  


<210> 449
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 449
Ser Tyr Leu Gln Asp Ser Asp Pro Asp Ser Phe Gln Asp 
1               5                   10              


<210> 450
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> tyrosinase

<400> 450
Phe Leu Leu His His Ala Phe Val Asp Ser Ile Phe Glu Gln Trp Leu 
1               5                   10                  15      


Gln Arg His Arg Pro 
            20      


<210> 451
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> adipophilin

<400> 451
Ser Val Ala Ser Thr Ile Thr Gly Val 
1               5                   


<210> 452
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> AIM-2

<400> 452
Arg Ser Asp Ser Gly Gln Gln Ala Arg Tyr 
1               5                   10  


<210> 453
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> ALDH1A1

<400> 453
Leu Leu Tyr Lys Leu Ala Asp Leu Ile 
1               5                   


<210> 454
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> BCLX(L)

<400> 454
Tyr Leu Asn Asp His Leu Glu Pro Trp Ile 
1               5                   10  


<210> 455
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> BING-4

<400> 455
Cys Gln Trp Gly Arg Leu Trp Gln Leu 
1               5                   


<210> 456
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CALCA

<400> 456
Val Leu Leu Gln Ala Gly Ser Leu His Ala 
1               5                   10  


<210> 457
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CD45

<400> 457
Lys Phe Leu Asp Ala Leu Ile Ser Leu 
1               5                   


<210> 458
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CD274

<400> 458
Leu Leu Asn Ala Phe Thr Val Thr Val 
1               5                   


<210> 459
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> CPSF

<400> 459
Lys Val His Pro Val Ile Trp Ser Leu 
1               5                   


<210> 460
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> peptide

<400> 460
Leu Met Leu Gln Asn Ala Leu Thr Thr Met 
1               5                   10  


<210> 461
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> cyclinD1

<400> 461
Leu Leu Gly Ala Thr Cys Met Phe Val 
1               5                   


<210> 462
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> peptide

<400> 462
Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val Val Ala Ala Val 
1               5                   10                  15  


<210> 463
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> DKK1

<400> 463
Ala Leu Gly Gly His Pro Leu Leu Gly Val 
1               5                   10  


<210> 464
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> ENAH(hMena)

<400> 464
Thr Met Asn Gly Ser Lys Ser Pro Val 
1               5                   


<210> 465
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EpCAM

<400> 465
Arg Tyr Gln Leu Asp Pro Lys Phe Ile 
1               5                   


<210> 466
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EphA3

<400> 466
Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly 
1               5                   10          


<210> 467
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> EZH2

<400> 467
Phe Met Val Glu Asp Glu Thr Val Leu 
1               5                   


<210> 468
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> FGF5

<400> 468
Asn Thr Tyr Ala Ser Pro Arg Phe Lys Phe 
1               5                   10  


<210> 469
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> glypican-3

<400> 469
Phe Val Gly Glu Phe Phe Thr Asp Val 
1               5                   


<210> 470
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> G250 / MN / CAIX

<400> 470
His Leu Ser Thr Ala Phe Ala Arg Val 
1               5                   


<210> 471
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 471
Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210> 472
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 472
Ile Ile Ser Ala Val Val Gly Ile Leu 
1               5                   


<210> 473
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 473
Ala Leu Cys Arg Trp Gly Leu Leu Leu 
1               5                   


<210> 474
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 474
Ile Leu His Asn Gly Ala Tyr Ser Leu 
1               5                   


<210> 475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 475
Arg Leu Leu Gln Glu Thr Glu Leu Val 
1               5                   


<210> 476
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 476
Val Val Leu Gly Val Val Phe Gly Ile 
1               5                   


<210> 477
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 477
Tyr Met Ile Met Val Lys Cys Trp Met Ile 
1               5                   10  


<210> 478
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 478
His Leu Tyr Gln Gly Cys Gln Val Val 
1               5                   


<210> 479
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 479
Tyr Leu Val Pro Gln Gln Gly Phe Phe Cys 
1               5                   10  


<210> 480
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 480
Pro Leu Gln Pro Glu Gln Leu Gln Val 
1               5                   


<210> 481
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 481
Thr Leu Glu Glu Ile Thr Gly Tyr Leu 
1               5                   


<210> 482
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 482
Ala Leu Ile His His Asn Thr His Leu 
1               5                   


<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 483
Pro Leu Thr Ser Ile Ile Ser Ala Val 
1               5                   


<210> 484
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 484
Val Leu Arg Glu Asn Thr Ser Pro Lys 
1               5                   


<210> 485
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HER-2 / neu

<400> 485
Thr Tyr Leu Pro Thr Asn Ala Ser Leu 
1               5                   


<210> 486
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HLA-DOB

<400> 486
Phe Leu Leu Gly Leu Ile Phe Leu Leu 
1               5                   


<210> 487
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Hepsin

<400> 487
Ser Leu Leu Ser Gly Asp Trp Val Leu 
1               5                   


<210> 488
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Hepsin

<400> 488
Gly Leu Gln Leu Gly Val Gln Ala Val 
1               5                   


<210> 489
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Hepsin

<400> 489
Pro Leu Thr Glu Tyr Ile Gln Pro Val 
1               5                   


<210> 490
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> IDO1

<400> 490
Ala Leu Leu Glu Ile Ala Ser Cys Leu 
1               5                   


<210> 491
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> IGF2B3

<400> 491
Asn Leu Ser Ser Ala Glu Val Val Val 
1               5                   


<210> 492
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> IGF2B3

<400> 492
Arg Leu Leu Val Pro Thr Gln Phe Val 
1               5                   


<210> 493
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> IL13Ralpha2

<400> 493
Trp Leu Pro Phe Gly Phe Ile Leu Ile 
1               5                   


<210> 494
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Intestinal carboxyl esterase

<400> 494
Ser Pro Arg Trp Trp Pro Thr Cys Leu 
1               5                   


<210> 495
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> alpha-foetoprotein

<400> 495
Gly Val Ala Leu Gln Thr Met Lys Gln 
1               5                   


<210> 496
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> alpha-foetoprotein

<400> 496
Phe Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210> 497
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> alpha-foetoprotein

<400> 497
Gln Leu Ala Val Ser Val Ile Leu Arg Val 
1               5                   10  


<210> 498
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Kallikrein 4

<400> 498
Phe Leu Gly Tyr Leu Ile Leu Gly Val 
1               5                   


<210> 499
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Kallikrein 4

<400> 499
Ser Val Ser Glu Ser Asp Thr Ile Arg Ser Ile Ser Ile Ala Ser 
1               5                   10                  15  


<210> 500
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Kallikrein 4

<400> 500
Leu Leu Ala Asn Gly Arg Met Pro Thr Val Leu Gln Cys Val Asn 
1               5                   10                  15  


<210> 501
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Kallikrein 4

<400> 501
Arg Met Pro Thr Val Leu Gln Cys Val Asn Val Ser Val Val Ser 
1               5                   10                  15  


<210> 502
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KIF20A

<400> 502
Leu Leu Ser Asp Asp Asp Val Val Val 
1               5                   


<210> 503
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KIF20A

<400> 503
Ala Gln Pro Asp Thr Ala Pro Leu Pro Val 
1               5                   10  


<210> 504
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> KIF20A

<400> 504
Cys Ile Ala Glu Gln Tyr His Thr Val 
1               5                   


<210> 505
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Lengsin

<400> 505
Phe Leu Pro Glu Phe Gly Ile Ser Ser Ala 
1               5                   10  


<210> 506
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> M-CSF

<400> 506
Leu Pro Ala Val Val Gly Leu Ser Pro Gly Glu Gln Glu Tyr 
1               5                   10                  


<210> 507
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MCSP

<400> 507
Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr Gly Ala Leu Gln 
1               5                   10                  15      


<210> 508
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> mdm-2

<400> 508
Val Leu Phe Tyr Leu Gly Gln Tyr 
1               5               


<210> 509
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Meloe

<400> 509
Thr Leu Asn Asp Glu Cys Trp Pro Ala 
1               5                   


<210> 510
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Meloe

<400> 510
Glu Arg Ile Ser Ser Thr Leu Asn Asp Glu Cys Trp Pro Ala 
1               5                   10                  


<210> 511
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Meloe

<400> 511
Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile 
1               5                   10      


<210> 512
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Meloe

<400> 512
Thr Ser Arg Glu Gln Phe Leu Pro Ser Glu Gly Ala Ala 
1               5                   10              


<210> 513
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Meloe

<400> 513
Cys Pro Pro Trp His Pro Ser Glu Arg Ile Ser Ser Thr Leu 
1               5                   10                  


<210> 514
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Midkine

<400> 514
Ala Leu Leu Ala Leu Thr Ser Ala Val 
1               5                   


<210> 515
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Midkine

<400> 515
Ala Gln Cys Gln Glu Thr Ile Arg Val 
1               5                   


<210> 516
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Midkine

<400> 516
Leu Thr Leu Leu Ala Leu Leu Ala Leu Thr Ser Ala Val Ala Lys 
1               5                   10                  15  


<210> 517
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MMP-2

<400> 517
Gly Leu Pro Pro Asp Val Gln Arg Val His 
1               5                   10  


<210> 518
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MMP-7

<400> 518
Ser Leu Phe Pro Asn Ser Pro Lys Trp Thr Ser Lys 
1               5                   10          


<210> 519
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUC1

<400> 519
Ser Thr Ala Pro Pro Val His Asn Val 
1               5                   


<210> 520
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUC1

<400> 520
Leu Leu Leu Leu Thr Val Leu Thr Val 
1               5                   


<210> 521
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUC1

<400> 521
Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr 
1               5                   10          


<210> 522
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> MUC5AC

<400> 522
Thr Cys Gln Pro Thr Cys Arg Ser Leu 
1               5                   


<210> 523
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> p53

<400> 523
Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210> 524
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> p53

<400> 524
Arg Met Pro Glu Ala Ala Pro Pro Val 
1               5                   


<210> 525
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> p53

<400> 525
Ser Gln Lys Thr Tyr Gln Gly Ser Tyr 
1               5                   


<210> 526
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> p53

<400> 526
Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln 
1               5                   10              


<210> 527
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> p53

<400> 527
His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu 
1               5                   10          


<210> 528
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PAX5

<400> 528
Thr Leu Pro Gly Tyr Pro Pro His Val 
1               5                   


<210> 529
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PBF

<400> 529
Cys Thr Ala Cys Arg Trp Lys Lys Ala Cys Gln Arg 
1               5                   10          


<210> 530
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PRAME

<400> 530
Val Leu Asp Gly Leu Asp Val Leu Leu 
1               5                   


<210> 531
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PRAME

<400> 531
Ser Leu Tyr Ser Phe Pro Glu Pro Glu Ala 
1               5                   10  


<210> 532
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PRAME

<400> 532
Ala Leu Tyr Val Asp Ser Leu Phe Phe Leu 
1               5                   10  


<210> 533
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PRAME

<400> 533
Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210> 534
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PRAME

<400> 534
Leu Tyr Val Asp Ser Leu Phe Phe Leu Cys 
1               5                   10  


<210> 535
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PSMA

<400> 535
Asn Tyr Ala Arg Thr Glu Asp Phe Phe 
1               5                   


<210> 536
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RAGE-1

<400> 536
Leu Lys Leu Ser Gly Val Val Arg Leu 
1               5                   


<210> 537
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RAGE-1

<400> 537
Pro Leu Pro Pro Ala Arg Asn Gly Gly Leu Gly 
1               5                   10      


<210> 538
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RAGE-1

<400> 538
Ser Pro Ser Ser Asn Arg Ile Arg Asn Thr 
1               5                   10  


<210> 539
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RGS5

<400> 539
Leu Ala Ala Leu Pro His Ser Cys Leu 
1               5                   


<210> 540
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RGS5

<400> 540
Gly Leu Ala Ser Phe Lys Ser Phe Leu Lys 
1               5                   10  


<210> 541
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RhoC

<400> 541
Arg Ala Gly Leu Gln Val Arg Lys Asn Lys 
1               5                   10  


<210> 542
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RNF43


<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> May or may not be present

<400> 542
Ala Leu Trp Pro Trp Leu Leu Met Ala Thr 
1               5                   10  


<210> 543
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RNF43

<400> 543
Asn Ser Gln Pro Val Trp Leu Cys Leu 
1               5                   


<210> 544
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> RU2AS

<400> 544
Leu Pro Arg Trp Pro Pro Pro Gln Leu 
1               5                   


<210> 545
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> secernin1

<400> 545
Lys Met Asp Ala Glu His Pro Glu Leu 
1               5                   


<210> 546
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SOX10

<400> 546
Ala Trp Ile Ser Lys Pro Pro Gly Val 
1               5                   


<210> 547
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SOX10

<400> 547
Ser Ala Trp Ile Ser Lys Pro Pro Gly Val 
1               5                   10  


<210> 548
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> STEAP1

<400> 548
Met Ile Ala Val Phe Leu Pro Ile Val 
1               5                   


<210> 549
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> STEAP1

<400> 549
His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu Val Ile Asn Lys 
1               5                   10                  15  


<210> 550
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> survivin

<400> 550
Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu 
1               5                   10  


<210> 551
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> survivin

<400> 551
Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn 
1               5                   10                  15  


<210> 552
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Telomerase

<400> 552
Ile Leu Ala Lys Phe Leu His Trp Leu Glu 
1               5                   10  


<210> 553
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Telomerase

<400> 553
Arg Leu Val Asp Asp Phe Leu Leu Val 
1               5                   


<210> 554
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Telomerase

<400> 554
Arg Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile 
1               5                   10                  15  


<210> 555
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Telomerase

<400> 555
Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu 
1               5                   10                  15  


<210> 556
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> TPBG

<400> 556
Arg Leu Ala Arg Leu Ala Leu Val Leu 
1               5                   


<210> 557
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> VEGF

<400> 557
Ser Arg Phe Gly Gly Ala Val Val Arg 
1               5                   


<210> 558
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> WT1

<400> 558
Thr Ser Glu Lys Arg Pro Phe Met Cys Ala Tyr 
1               5                   10      


<210> 559
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> WT1

<400> 559
Cys Met Thr Trp Asn Gln Met Asn Leu 
1               5                   


<210> 560
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> WT1

<400> 560
Leu Ser His Leu Gln Met His Ser Arg Lys His 
1               5                   10      


<210> 561
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> WT1

<400> 561
Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met His Ser Arg Lys His 
1               5                   10                  15      


<210> 562
<211> 504
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> single chain variable fragment fusion protein

<400> 562
Asp Ile Gln Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Leu Asn Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Val Ser Gly Ile Pro Pro 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Lys Val Asp Ala Ala Thr Tyr His Cys Gln Gln Ser Thr 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met 
145                 150                 155                 160 


Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Gln 
                165                 170                 175     


Ile Trp Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
    210                 215                 220                 


Arg Glu Thr Thr Thr Val Gly Arg Tyr Tyr Tyr Ala Met Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
                245                 250                 255     


Ile Lys Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
            260                 265                 270         


Val Lys Met Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
        275                 280                 285             


Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
    290                 295                 300                 


Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
305                 310                 315                 320 


Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met 
                325                 330                 335     


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Leu Thr Val Ser Ser Val Glu Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Val Asp Asp Ile Gln Leu Thr Gln Ser Pro 
385                 390                 395                 400 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
                405                 410                 415     


Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly 
            420                 425                 430         


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly 
        435                 440                 445             


Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
    450                 455                 460                 


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
465                 470                 475                 480 


Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
                485                 490                 495     


Leu Lys His His His His His His 
            500                 


<210> 563
<211> 290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR Responsive Promoter

<400> 563
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa                 290


<210> 564
<211> 173
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR Responsive Promoter

<400> 564
atttcctctc atcccatccg gggtgagagt cttttccccc gacttatggc tcatgcatgc       60

atcaaaaaag atgtgagctt gatcaaaaac aaaaaatatt tcactcgaca ggagtattta      120

tattgcgccc gttacgtggg cttcgactgt aaatcagaaa ggagaaaaca cct             173


<210> 565
<211> 305
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR Responsive Promoter

<400> 565
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggat ccctctagaa ataattttgt ttaactttaa gaaggagata      300

tacat                                                                  305


<210> 566
<211> 180
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR Responsive Promoter

<400> 566
catttcctct catcccatcc ggggtgagag tcttttcccc cgacttatgg ctcatgcatg       60

catcaaaaaa gatgtgagct tgatcaaaaa caaaaaatat ttcactcgac aggagtattt      120

atattgcgcc cggatccctc tagaaataat tttgtttaac tttaagaagg agatatacat      180


<210> 567
<211> 199
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR Responsive Promoter

<400> 567
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgtaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccctct agaaataatt ttgtttaact      180

ttaagaagga gatatacat                                                   199


<210> 568
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR-responsive regulatory region

<400> 568
atccccatca ctcttgatgg agatcaattc cccaagctgc tagagcgtta ccttgccctt       60

aaacattagc aatgtcgatt tatcagaggg ccgacaggct cccacaggag aaaaccg         117


<210> 569
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNR-responsive regulatory region

<400> 569
ctcttgatcg ttatcaattc ccacgctgtt tcagagcgtt accttgccct taaacattag       60

caatgtcgat ttatcagagg gccgacaggc tcccacagga gaaaaccg                   108


<210> 570
<211> 290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> nirB1 , FNR-responsive regulatory region

<400> 570
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa                 290


<210> 571
<211> 433
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> nirB2 , FNR-responsive regulatory region

<400> 571
cggcccgatc gttgaacata gcggtccgca ggcggcactg cttacagcaa acggtctgta       60

cgctgtcgtc tttgtgatgt gcttcctgtt aggtttcgtc agccgtcacc gtcagcataa      120

caccctgacc tctcattaat tgctcatgcc ggacggcact atcgtcgtcc ggccttttcc      180

tctcttcccc cgctacgtgc atctatttct ataaacccgc tcattttgtc tattttttgc      240

acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa tcagcaatat      300

acccattaag gagtatataa aggtgaattt gatttacatc aataagcggg gttgctgaat      360

cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa atgtttgttt aactttaaga      420

aggagatata cat                                                         433


<210> 572
<211> 290
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> nirB3 , FNR-responsive regulatory region

<400> 572
gtcagcataa caccctgacc tctcattaat tgctcatgcc ggacggcact atcgtcgtcc       60

ggccttttcc tctcttcccc cgctacgtgc atctatttct ataaacccgc tcattttgtc      120

tattttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat acccattaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggta ggcggtaata gaaaagaaat cgaggcaaaa                 290


<210> 573
<211> 173
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> ydfZ , FNR-responsive regulatory region

<400> 573
atttcctctc atcccatccg gggtgagagt cttttccccc gacttatggc tcatgcatgc       60

atcaaaaaag atgtgagctt gatcaaaaac aaaaaatatt tcactcgaca ggagtattta      120

tattgcgccc gttacgtggg cttcgactgt aaatcagaaa ggagaaaaca cct             173


<210> 574
<211> 305
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> nirB+RBS , FNR-responsive regulatory region

<400> 574
gtcagcataa caccctgacc tctcattaat tgttcatgcc gggcggcact atcgtcgtcc       60

ggccttttcc tctcttactc tgctacgtac atctatttct ataaatccgt tcaatttgtc      120

tgttttttgc acaaacatga aatatcagac aattccgtga cttaagaaaa tttatacaaa      180

tcagcaatat accccttaag gagtatataa aggtgaattt gatttacatc aataagcggg      240

gttgctgaat cgttaaggat ccctctagaa ataattttgt ttaactttaa gaaggagata      300

tacat                                                                  305


<210> 575
<211> 180
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> ydfZ+RBS , FNR-responsive regulatory region

<400> 575
catttcctct catcccatcc ggggtgagag tcttttcccc cgacttatgg ctcatgcatg       60

catcaaaaaa gatgtgagct tgatcaaaaa caaaaaatat ttcactcgac aggagtattt      120

atattgcgcc cggatccctc tagaaataat tttgtttaac tttaagaagg agatatacat      180


<210> 576
<211> 199
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNRS1 , FNR-responsive regulatory region

<400> 576
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgtaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccctct agaaataatt ttgtttaact      180

ttaagaagga gatatacat                                                   199


<210> 577
<211> 207
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNRS2 , FNR-responsive regulatory region

<400> 577
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccaaag tgaactctag aaataatttt      180

gtttaacttt aagaaggaga tatacat                                          207


<210> 578
<211> 390
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> nirB+crp , FNR-responsive regulatory region

<400> 578
tcgtctttgt gatgtgcttc ctgttaggtt tcgtcagccg tcaccgtcag cataacaccc       60

tgacctctca ttaattgctc atgccggacg gcactatcgt cgtccggcct tttcctctct      120

tcccccgcta cgtgcatcta tttctataaa cccgctcatt ttgtctattt tttgcacaaa      180

catgaaatat cagacaattc cgtgacttaa gaaaatttat acaaatcagc aatataccca      240

ttaaggagta tataaaggtg aatttgattt acatcaataa gcggggttgc tgaatcgtta      300

aggtagaaat gtgatctagt tcacatttgc ggtaatagaa aagaaatcga ggcaaaaatg      360

tttgtttaac tttaagaagg agatatacat                                       390


<210> 579
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FNRS+crp , FNR-responsive regulatory region

<400> 579
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctcaa atgtgatcta gttcacattt tttgtttaac      180

tttaagaagg agatatacat                                                  200


<210> 580
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> katG, Regulatory sequence

<400> 580
tgtggctttt atgaaaatca cacagtgatc acaaatttta aacagagcac aaaatgctgc       60

ctcgaaatga gggcgggaaa ataaggttat cagccttgtt ttctccctca ttacttgaag      120

gatatgaagc taaaaccctt ttttataaag catttgtccg aattcggaca taatcaaaaa      180

agcttaatta agatcaattt gatctacatc tctttaacca acaatatgta agatctcaac      240

tatcgcatcc gtggattaat tcaattataa cttctctcta acgctgtgta tcgtaacggt      300

aacactgtag aggggagcac attgatgcga attcattaaa gaggagaaag gtacc           355


<210> 581
<211> 228
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Dps, Regulatory sequence

<400> 581
ttccgaaaat tcctggcgag cagataaata agaattgttc ttatcaatat atctaactca       60

ttgaatcttt attagttttg tttttcacgc ttgttaccac tattagtgtg ataggaacag      120

ccagaatagc ggaacacata gccggtgcta tacttaatct cgttaattac tgggacataa      180

catcaagagg atatgaaatt cgaattcatt aaagaggaga aaggtacc                   228


<210> 582
<211> 334
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> ahpC, Regulatory sequence

<400> 582
gcttagatca ggtgattgcc ctttgtttat gagggtgttg taatccatgt cgttgttgca       60

tttgtaaggg caacacctca gcctgcaggc aggcactgaa gataccaaag ggtagttcag      120

attacacggt cacctggaaa gggggccatt ttacttttta tcgccgctgg cggtgcaaag      180

ttcacaaagt tgtcttacga aggttgtaag gtaaaactta tcgatttgat aatggaaacg      240

cattagccga atcggcaaaa attggttacc ttacatctca tcgaaaacac ggaggaagta      300

tagatgcgaa ttcattaaag aggagaaagg tacc                                  334


<210> 583
<211> 134
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> oxyS Regulatory sequence

<400> 583
ctcgagttca ttatccatcc tccatcgcca cgatagttca tggcgatagg tagaatagca       60

atgaacgatt atccctatca agcattctga ctgataattg ctcacacgaa ttcattaaag      120

aggagaaagg tacc                                                        134


<210> 584
<211> 1921
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Prp (Propionate)

<400> 584
ttacccgtct ggattttcag tacgcgcttt taaacgacgc cacagcgtgg tacggctgat       60

ccccaaataa cgtgcggcgg cgcgcttatc gccattaaag cgtgcgagca cctcctgcaa      120

tggaagcgct tctgctgacg agggcgtgat ttctgctgtg gtccccacca gttcaggtaa      180

taattgccgc ataaattgtc tgtccagtgt tggtgcggga tcgacgctta aaaaaagcgc      240

caggcgttcc atcatattcc gcagttcgcg aatattaccg ggccaatgat agttcagtag      300

aagcggctga cactgcgtca gcccatgacg caccgattcg gtaaaaggga tctccatcgc      360

ggccagcgat tgttttaaaa agttttccgc cagaggcaga atatcaggct gtcgctcgcg      420

caagggggga agcggcagac gcagaatgct caaacggtaa aacagatcgg tacgaaaacg      480

tccttgcgtt atctcccgat ccagatcgca atgcgtggcg ctgatcaccc ggacatctac      540

cgggatcggc tgatgcccgc caacgcgggt gacggctttt tcctccagta cgcgtagaag      600

gcgggtttgt aacggcagcg gcatttcgcc aatttcgtca agaaacagcg tgccgccgtg      660

ggcgacctca aacagccccg cacgtccacc tcgtcttgag ccggtaaacg ctccctcctc      720

atagccaaac agttcagcct ccagcaacga ctcggtaatc gcgccgcaat taacggcgac      780

aaagggcgga gaaggcttgt tctgacggtg gggctgacgg ttaaacaacg cctgatgaat      840

cgcttgcgcc gccagctctt tcccggtccc tgtttccccc tgaatcagca ctgccgcgcg      900

ggaacgggca tagagtgtaa tcgtatggcg aacctgctcc atttgtggtg aatcgccgag      960

gatatcgctc agcgcataac gggtctgtaa tcccttgctg gaggtatgct ggctatactg     1020

acgccgtgtc aggcgggtca tatccagcgc atcatggaaa gcctgacgta cggtggccgc     1080

tgaataaata aagatggcgg tcattcctgc ctcttccgcc aggtcggtaa ttagtcctgc     1140

cccaattaca gcctcaatgc cgttagcttt gagctcgtta atttgcccgc gagcatcctc     1200

ttcagtgata tagcttcgct gttcaagacg gaggtgaaac gttttctgaa aggcgaccag     1260

agccggaatg gtctcctgat aggtcacgat tcccattgag gaagtcagct ttcccgcttt     1320

tgccagagcc tgtaatacat cgaatccgct gggtttgatg aggatgacag gtaccgacag     1380

tcggcttttt aaataagcgc cgttggaacc tgccgcgata atcgcgtcgc agcgttcggt     1440

tgccagtttt ttgcgaatgt aggctactgc cttttcaaaa ccgagctgaa taggcgtgat     1500

cgtcgccaga tgatcaaact ccaggctgat atcccgaaat agttcgaaca ggcgcgttac     1560

cgagaccgtc cagatcaccg gtttatcgct attatcgcgc gaagcgctat gcacagtaac     1620

catcgtcgta gattcatgtt taaggaacga attcttgttt tatagatgtt tcgttaatgt     1680

tgcaatgaaa cacaggcctc cgtttcatga aacgttagct gactcgtttt tcttgtgact     1740

cgtctgtcag tattaaaaaa gatttttcat ttaactgatt gtttttaaat tgaattttat     1800

ttaatggttt ctcggttttt gggtctggca tatcccttgc tttaatgagt gcatcttaat     1860

taacaattca ataacaagag ggctgaatag taatttcaac aaaataacga gcattcgaat     1920

g                                                                     1921


<210> 585
<211> 305
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Arabinose Promoter region

<400> 585
cagacattgc cgtcactgcg tcttttactg gctcttctcg ctaacccaac cggtaacccc       60

gcttattaaa agcattctgt aacaaagcgg gaccaaagcc atgacaaaaa cgcgtaacaa      120

aagtgtctat aatcacggca gaaaagtcca cattgattat ttgcacggcg tcacactttg      180

ctatgccata gcatttttat ccataagatt agcggatcca gcctgacgct ttttttcgca      240

actctctact gtttctccat acctctagaa ataattttgt ttaactttaa gaaggagata      300

tacat                                                                  305


<210> 586
<211> 897
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> AraC (reverse orientation)

<400> 586
ttattcacaa cctgccctaa actcgctcgg actcgccccg gtgcattttt taaatactcg       60

cgagaaatag agttgatcgt caaaaccgac attgcgaccg acggtggcga taggcatccg      120

ggtggtgctc aaaagcagct tcgcctgact gatgcgctgg tcctcgcgcc agcttaatac      180

gctaatccct aactgctggc ggaacaaatg cgacagacgc gacggcgaca ggcagacatg      240

ctgtgcgacg ctggcgatat caaaattact gtctgccagg tgatcgctga tgtactgaca      300

agcctcgcgt acccgattat ccatcggtgg atggagcgac tcgttaatcg cttccatgcg      360

ccgcagtaac aattgctcaa gcagatttat cgccagcaat tccgaatagc gcccttcccc      420

ttgtccggca ttaatgattt gcccaaacag gtcgctgaaa tgcggctggt gcgcttcatc      480

cgggcgaaag aaaccggtat tggcaaatat cgacggccag ttaagccatt catgccagta      540

ggcgcgcgga cgaaagtaaa cccactggtg ataccattcg tgagcctccg gatgacgacc      600

gtagtgatga atctctccag gcgggaacag caaaatatca cccggtcggc agacaaattc      660

tcgtccctga tttttcacca ccccctgacc gcgaatggtg agattgagaa tataaccttt      720

cattcccagc ggtcggtcga taaaaaaatc gagataaccg ttggcctcaa tcggcgttaa      780

acccgccacc agatgggcgt taaacgagta tcccggcagc aggggatcat tttgcgcttc      840

agccatactt ttcatactcc cgccattcag agaagaaacc aattgtccat attgcat         897


<210> 587
<211> 298
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> AraC polypeptide

<400> 587
Met Gln Tyr Gly Gln Leu Val Ser Ser Leu Asn Gly Gly Ser Met Lys 
1               5                   10                  15      


Ser Met Ala Glu Ala Gln Asn Asp Pro Leu Leu Pro Gly Tyr Ser Phe 
            20                  25                  30          


Asn Ala His Leu Val Ala Gly Leu Thr Pro Ile Glu Ala Asn Gly Tyr 
        35                  40                  45              


Leu Asp Phe Phe Ile Asp Arg Pro Leu Gly Met Lys Gly Tyr Ile Leu 
    50                  55                  60                  


Asn Leu Thr Ile Arg Gly Gln Gly Val Val Lys Asn Gln Gly Arg Glu 
65                  70                  75                  80  


Phe Val Cys Arg Pro Gly Asp Ile Leu Leu Phe Pro Pro Gly Glu Ile 
                85                  90                  95      


His His Tyr Gly Arg His Pro Glu Ala His Glu Trp Tyr His Gln Trp 
            100                 105                 110         


Val Tyr Phe Arg Pro Arg Ala Tyr Trp His Glu Trp Leu Asn Trp Pro 
        115                 120                 125             


Ser Ile Phe Ala Asn Thr Gly Phe Phe Arg Pro Asp Glu Ala His Gln 
    130                 135                 140                 


Pro His Phe Ser Asp Leu Phe Gly Gln Ile Ile Asn Ala Gly Gln Gly 
145                 150                 155                 160 


Glu Gly Arg Tyr Ser Glu Leu Leu Ala Ile Asn Leu Leu Glu Gln Leu 
                165                 170                 175     


Leu Leu Arg Arg Met Glu Ala Ile Asn Glu Ser Leu His Pro Pro Met 
            180                 185                 190         


Asp Asn Arg Val Arg Glu Ala Cys Gln Tyr Ile Ser Asp His Leu Ala 
        195                 200                 205             


Asp Ser Asn Phe Asp Ile Ala Ser Val Ala Gln His Val Cys Leu Ser 
    210                 215                 220                 


Pro Ser Arg Leu Ser His Leu Phe Arg Gln Gln Leu Gly Ile Ser Val 
225                 230                 235                 240 


Leu Ser Trp Arg Glu Asp Gln Arg Ile Ser Gln Ala Lys Leu Leu Leu 
                245                 250                 255     


Ser Thr Thr Arg Met Pro Ile Ala Thr Val Gly Arg Asn Val Gly Phe 
            260                 265                 270         


Asp Asp Gln Leu Tyr Phe Ser Arg Val Phe Lys Lys Cys Thr Gly Ala 
        275                 280                 285             


Ser Pro Ser Glu Phe Arg Ala Gly Cys Glu 
    290                 295             


<210> 588
<211> 280
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Region comprising rhamnose inducible promoter

<400> 588
cggtgagcat cacatcacca caattcagca aattgtgaac atcatcacgt tcatctttcc       60

ctggttgcca atggcccatt ttcctgtcag taacgagaag gtcgcgaatc aggcgctttt      120

tagactggtc gtaatgaaat tcagctgtca ccggatgtgc tttccggtct gatgagtccg      180

tgaggacgaa acagcctcta caaataattt tgtttaaaac aacacccact aagataactc      240

tagaaataat tttgtttaac tttaagaagg agatatacat                            280


<210> 589
<211> 326
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Lac Promoter region

<400> 589
attcaccacc ctgaattgac tctcttccgg gcgctatcat gccataccgc gaaaggtttt       60

gcgccattcg atggcgcgcc gcttcgtcag gccacatagc tttcttgttc tgatcggaac      120

gatcgttggc tgtgttgaca attaatcatc ggctcgtata atgtgtggaa ttgtgagcgc      180

tcacaattag ctgtcaccgg atgtgctttc cggtctgatg agtccgtgag gacgaaacag      240

cctctacaaa taattttgtt taaaacaaca cccactaaga taactctaga aataattttg      300

tttaacttta agaaggagat atacat                                           326


<210> 590
<211> 1083
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> LacI (in reverse orientation)

<400> 590
tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa       60

cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt tcaccagtga      120

gactggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca gcaagcggtc      180

cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg gcgggatata      240

acatgagcta tcttcggtat cgtcgtatcc cactaccgag atatccgcac caacgcgcag      300

cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg caaccagcat      360

cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac cggacatggc      420

actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga gatatttatg      480

ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta acagcgcgat      540

ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt cctcatggga      600

gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg ccggaacatt      660

agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt taatgatcag      720

cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt cgacgccgct      780

tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag atttaatcgc      840

cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc caatcagcaa      900

cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca gctccgccat      960

cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg     1020

ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg ttactggttt     1080

cat                                                                   1083


<210> 591
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> LacI polypeptide sequence

<400> 591
Met Lys Pro Val Thr Leu Tyr Asp Val Ala Glu Tyr Ala Gly Val Ser 
1               5                   10                  15      


Tyr Gln Thr Val Ser Arg Val Val Asn Gln Ala Ser His Val Ser Ala 
            20                  25                  30          


Lys Thr Arg Glu Lys Val Glu Ala Ala Met Ala Glu Leu Asn Tyr Ile 
        35                  40                  45              


Pro Asn Arg Val Ala Gln Gln Leu Ala Gly Lys Gln Ser Leu Leu Ile 
    50                  55                  60                  


Gly Val Ala Thr Ser Ser Leu Ala Leu His Ala Pro Ser Gln Ile Val 
65                  70                  75                  80  


Ala Ala Ile Lys Ser Arg Ala Asp Gln Leu Gly Ala Ser Val Val Val 
                85                  90                  95      


Ser Met Val Glu Arg Ser Gly Val Glu Ala Cys Lys Ala Ala Val His 
            100                 105                 110         


Asn Leu Leu Ala Gln Arg Val Ser Gly Leu Ile Ile Asn Tyr Pro Leu 
        115                 120                 125             


Asp Asp Gln Asp Ala Ile Ala Val Glu Ala Ala Cys Thr Asn Val Pro 
    130                 135                 140                 


Ala Leu Phe Leu Asp Val Ser Asp Gln Thr Pro Ile Asn Ser Ile Ile 
145                 150                 155                 160 


Phe Ser His Glu Asp Gly Thr Arg Leu Gly Val Glu His Leu Val Ala 
                165                 170                 175     


Leu Gly His Gln Gln Ile Ala Leu Leu Ala Gly Pro Leu Ser Ser Val 
            180                 185                 190         


Ser Ala Arg Leu Arg Leu Ala Gly Trp His Lys Tyr Leu Thr Arg Asn 
        195                 200                 205             


Gln Ile Gln Pro Ile Ala Glu Arg Glu Gly Asp Trp Ser Ala Met Ser 
    210                 215                 220                 


Gly Phe Gln Gln Thr Met Gln Met Leu Asn Glu Gly Ile Val Pro Thr 
225                 230                 235                 240 


Ala Met Leu Val Ala Asn Asp Gln Met Ala Leu Gly Ala Met Arg Ala 
                245                 250                 255     


Ile Thr Glu Ser Gly Leu Arg Val Gly Ala Asp Ile Ser Val Val Gly 
            260                 265                 270         


Tyr Asp Asp Thr Glu Asp Ser Ser Cys Tyr Ile Pro Pro Leu Thr Thr 
        275                 280                 285             


Ile Lys Gln Asp Phe Arg Leu Leu Gly Gln Thr Ser Val Asp Arg Leu 
    290                 295                 300                 


Leu Gln Leu Ser Gln Gly Gln Ala Val Lys Gly Asn Gln Leu Leu Pro 
305                 310                 315                 320 


Val Ser Leu Val Lys Arg Lys Thr Thr Leu Ala Pro Asn Thr Gln Thr 
                325                 330                 335     


Ala Ser Pro Arg Ala Leu Ala Asp Ser Leu Met Gln Leu Ala Arg Gln 
            340                 345                 350         


Val Ser Arg Leu Glu Ser Gly Gln 
        355                 360 


<210> 592
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Region comprising Temperature sensitive promoter

<400> 592
acgttaaatc tatcaccgca agggataaat atctaacacc gtgcgtgttg actattttac       60

ctctggcggt gataatggtt gcatagctgt caccggatgt gctttccggt ctgatgagtc      120

cgtgaggacg aaacagcctc tacaaataat tttgtttaaa acaacaccca ctaagataac      180

tctagaaata attttgttta actttaagaa ggagatatac at                         222


<210> 593
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> mutant cI857 repressor

<400> 593
tcagccaaac gtctcttcag gccactgact agcgataact ttccccacaa cggaacaact       60

ctcattgcat gggatcattg ggtactgtgg gtttagtggt tgtaaaaaca cctgaccgct      120

atccctgatc agtttcttga aggtaaactc atcaccccca agtctggcta tgcagaaatc      180

acctggctca acagcctgct cagggtcaac gagaattaac attccgtcag gaaagcttgg      240

cttggagcct gttggtgcgg tcatggaatt accttcaacc tcaagccaga atgcagaatc      300

actggctttt ttggttgtgc ttacccatct ctccgcatca cctttggtaa aggttctaag      360

cttaggtgag aacatccctg cctgaacatg agaaaaaaca gggtactcat actcacttct      420

aagtgacggc tgcatactaa ccgcttcata catctcgtag atttctctgg cgattgaagg      480

gctaaattct tcaacgctaa ctttgagaat ttttgtaagc aatgcggcgt tataagcatt      540

taatgcattg atgccattaa ataaagcacc aacgcctgac tgccccatcc ccatcttgtc      600

tgcgacagat tcctgggata agccaagttc atttttcttt ttttcataaa ttgctttaag      660

gcgacgtgcg tcctcaagct gctcttgtgt taatggtttc ttttttgtgc tcat            714


<210> 594
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> RBS and leader region

<400> 594
ctctagaaat aattttgttt aactttaaga aggagatata cat                         43


<210> 595
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> mutant cI857 repressor polypeptide sequence

<400> 595
Met Ser Thr Lys Lys Lys Pro Leu Thr Gln Glu Gln Leu Glu Asp Ala 
1               5                   10                  15      


Arg Arg Leu Lys Ala Ile Tyr Glu Lys Lys Lys Asn Glu Leu Gly Leu 
            20                  25                  30          


Ser Gln Glu Ser Val Ala Asp Lys Met Gly Met Gly Gln Ser Gly Val 
        35                  40                  45              


Gly Ala Leu Phe Asn Gly Ile Asn Ala Leu Asn Ala Tyr Asn Ala Ala 
    50                  55                  60                  


Leu Leu Thr Lys Ile Leu Lys Val Ser Val Glu Glu Phe Ser Pro Ser 
65                  70                  75                  80  


Ile Ala Arg Glu Ile Tyr Glu Met Tyr Glu Ala Val Ser Met Gln Pro 
                85                  90                  95      


Ser Leu Arg Ser Glu Tyr Glu Tyr Pro Val Phe Ser His Val Gln Ala 
            100                 105                 110         


Gly Met Phe Ser Pro Lys Leu Arg Thr Phe Thr Lys Gly Asp Ala Glu 
        115                 120                 125             


Arg Trp Val Ser Thr Thr Lys Lys Ala Ser Asp Ser Ala Phe Trp Leu 
    130                 135                 140                 


Glu Val Glu Gly Asn Ser Met Thr Ala Pro Thr Gly Ser Lys Pro Ser 
145                 150                 155                 160 


Phe Pro Asp Gly Met Leu Ile Leu Val Asp Pro Glu Gln Ala Val Glu 
                165                 170                 175     


Pro Gly Asp Phe Cys Ile Ala Arg Leu Gly Gly Asp Glu Phe Thr Phe 
            180                 185                 190         


Lys Lys Leu Ile Arg Asp Ser Gly Gln Val Phe Leu Gln Pro Leu Asn 
        195                 200                 205             


Pro Gln Tyr Pro Met Ile Pro Cys Asn Glu Ser Cys Ser Val Val Gly 
    210                 215                 220                 


Lys Val Ile Ala Ser Gln Trp Pro Glu Glu Thr Phe Gly 
225                 230                 235         


<210> 596
<211> 748
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> TetR-Tet promoter construct

<400> 596
ttaagaccca ctttcacatt taagttgttt ttctaatccg catatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acatcattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaactcta gaaataattt      720

tgtttaactt taagaaggag atatacat                                         748


<210> 597
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> PssB promoter

<400> 597
tcacctttcc cggattaaac gcttttttgc ccggtggcat ggtgctaccg gcgatcacaa       60

acggttaatt atgacacaaa ttgacctgaa tgaatataca gtattggaat gcattacccg      120

gagtgttgtg taacaatgtc tggccaggtt tgtttcccgg aaccgaggtc acaacatagt      180

aaaagcgcta ttggtaatgg tacaatcgcg cgtttacact tattc                      225


<210> 598
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I14018

<400> 598
gtttatacat aggcgagtac tctgttatgg                                        30


<210> 599
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I14033

<400> 599
agaggttcca actttcacca taatgaaaca                                        30


<210> 600
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I14034

<400> 600
taaacaacta acggacaatt ctacctaaca                                        30


<210> 601
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I732021

<400> 601
acatcaagcc aaattaaaca ggattaacac                                        30


<210> 602
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I742126

<400> 602
gaggtaaaat agtcaacacg cacggtgtta                                        30


<210> 603
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J01006

<400> 603
caggccggaa taactcccta taatgcgcca                                        30


<210> 604
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23100

<400> 604
ggctagctca gtcctaggta cagtgctagc                                        30


<210> 605
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23101

<400> 605
agctagctca gtcctaggta ttatgctagc                                        30


<210> 606
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23102

<400> 606
agctagctca gtcctaggta ctgtgctagc                                        30


<210> 607
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23103

<400> 607
agctagctca gtcctaggga ttatgctagc                                        30


<210> 608
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23104

<400> 608
agctagctca gtcctaggta ttgtgctagc                                        30


<210> 609
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23105

<400> 609
ggctagctca gtcctaggta ctatgctagc                                        30


<210> 610
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23106

<400> 610
ggctagctca gtcctaggta tagtgctagc                                        30


<210> 611
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23107

<400> 611
ggctagctca gccctaggta ttatgctagc                                        30


<210> 612
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23108

<400> 612
agctagctca gtcctaggta taatgctagc                                        30


<210> 613
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23109

<400> 613
agctagctca gtcctaggga ctgtgctagc                                        30


<210> 614
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23110

<400> 614
ggctagctca gtcctaggta caatgctagc                                        30


<210> 615
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23111

<400> 615
ggctagctca gtcctaggta tagtgctagc                                        30


<210> 616
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23112

<400> 616
agctagctca gtcctaggga ttatgctagc                                        30


<210> 617
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23113

<400> 617
ggctagctca gtcctaggga ttatgctagc                                        30


<210> 618
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23114

<400> 618
ggctagctca gtcctaggta caatgctagc                                        30


<210> 619
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23115

<400> 619
agctagctca gcccttggta caatgctagc                                        30


<210> 620
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23116

<400> 620
agctagctca gtcctaggga ctatgctagc                                        30


<210> 621
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23117

<400> 621
agctagctca gtcctaggga ttgtgctagc                                        30


<210> 622
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23118

<400> 622
ggctagctca gtcctaggta ttgtgctagc                                        30


<210> 623
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23119

<400> 623
agctagctca gtcctaggta taatgctagc                                        30


<210> 624
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23150

<400> 624
ggctagctca gtcctaggta ttatgctagc                                        30


<210> 625
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J23151

<400> 625
ggctagctca gtcctaggta caatgctagc                                        30


<210> 626
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J44002

<400> 626
aaagtgtgac gccgtgcaaa taatcaatgt                                        30


<210> 627
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J48104

<400> 627
gacgaatact taaaatcgtc atacttattt                                        30


<210> 628
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J54200

<400> 628
aaacctttcg cggtatggca tgatagcgcc                                        30


<210> 629
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J56015

<400> 629
tgatagcgcc cggaagagag tcaattcagg                                        30


<210> 630
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J64951

<400> 630
ttatttaccg tgacgaacta attgctcgtg                                        30


<210> 631
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K088007

<400> 631
catacgccgt tatacgttgt ttacgctttg                                        30


<210> 632
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K119000

<400> 632
ttatgcttcc ggctcgtatg ttgtgtggac                                        30


<210> 633
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K119001

<400> 633
ttatgcttcc ggctcgtatg gtgtgtggac                                        30


<210> 634
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1330002

<400> 634
ggctagctca gtcctaggta ctatgctagc                                        30


<210> 635
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137029

<400> 635
atatatatat atatataatg gaagcgtttt                                        30


<210> 636
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137030

<400> 636
atatatatat atatataatg gaagcgtttt                                        30


<210> 637
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137031

<400> 637
ccccgaaagc ttaagaatat aattgtaagc                                        30


<210> 638
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137032

<400> 638
ccccgaaagc ttaagaatat aattgtaagc                                        30


<210> 639
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137085

<400> 639
tgacaatata tatatatata taatgctagc                                        30


<210> 640
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137086

<400> 640
acaatatata tatatatata taatgctagc                                        30


<210> 641
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137087

<400> 641
aatatatata tatatatata taatgctagc                                        30


<210> 642
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137088

<400> 642
tatatatata tatatatata taatgctagc                                        30


<210> 643
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137089

<400> 643
tatatatata tatatatata taatgctagc                                        30


<210> 644
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137090

<400> 644
aaaaaaaaaa aaaaaaaata taatgctagc                                        30


<210> 645
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K137091

<400> 645
aaaaaaaaaa aaaaaaaata taatgctagc                                        30


<210> 646
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585100

<400> 646
ggaattgtga gcggataaca atttcacaca                                        30


<210> 647
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585101

<400> 647
ggaattgtga gcggataaca atttcacaca                                        30


<210> 648
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585102

<400> 648
ggaattgtga gcggataaca atttcacaca                                        30


<210> 649
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585103

<400> 649
ggaattgtga gcggataaca atttcacaca                                        30


<210> 650
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585104

<400> 650
ggaattgtga gcggataaca atttcacaca                                        30


<210> 651
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585105

<400> 651
ggaattgtga gcggataaca atttcacaca                                        30


<210> 652
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585106

<400> 652
ggaattgtga gcggataaca atttcacaca                                        30


<210> 653
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585110

<400> 653
ggaattgtga gcggataaca atttcacaca                                        30


<210> 654
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585113

<400> 654
ggaattgtga gcggataaca atttcacaca                                        30


<210> 655
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585115

<400> 655
ggaattgtga gcggataaca atttcacaca                                        30


<210> 656
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585116

<400> 656
ggaattgtga gcggataaca atttcacaca                                        30


<210> 657
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585117

<400> 657
ggaattgtga gcggataaca atttcacaca                                        30


<210> 658
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585118

<400> 658
ggaattgtga gcggataaca atttcacaca                                        30


<210> 659
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1585119

<400> 659
ggaattgtga gcggataaca atttcacaca                                        30


<210> 660
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1824896

<400> 660
gattaaagag gagaaatact agagtactag                                        30


<210> 661
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K256002

<400> 661
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 662
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K256018

<400> 662
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 663
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K256020

<400> 663
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 664
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K256033

<400> 664
caccttcggg tgggcctttc tgcgtttata                                        30


<210> 665
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K292000

<400> 665
ggctagctca gtcctaggta cagtgctagc                                        30


<210> 666
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K292001

<400> 666
tgctagctac tagagattaa agaggagaaa                                        30


<210> 667
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K418000

<400> 667
ttgtgagcgg ataacaagat actgagcaca                                        30


<210> 668
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K418002

<400> 668
ttgtgagcgg ataacaagat actgagcaca                                        30


<210> 669
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K418003

<400> 669
ttgtgagcgg ataacaagat actgagcaca                                        30


<210> 670
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823004

<400> 670
ggctagctca gtcctaggta cagtgctagc                                        30


<210> 671
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823005

<400> 671
agctagctca gtcctaggta ttatgctagc                                        30


<210> 672
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823006

<400> 672
agctagctca gtcctaggta ctgtgctagc                                        30


<210> 673
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823007

<400> 673
agctagctca gtcctaggga ttatgctagc                                        30


<210> 674
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823008

<400> 674
ggctagctca gtcctaggta tagtgctagc                                        30


<210> 675
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823010

<400> 675
ggctagctca gtcctaggga ttatgctagc                                        30


<210> 676
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823011

<400> 676
ggctagctca gtcctaggta caatgctagc                                        30


<210> 677
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823013

<400> 677
agctagctca gtcctaggga ttgtgctagc                                        30


<210> 678
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823014

<400> 678
ggctagctca gtcctaggta ttgtgctagc                                        30


<210> 679
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13101

<400> 679
cctgttttta tgttattctc tctgtaaagg                                        30


<210> 680
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13102

<400> 680
aaatatttgc ttatacaatc ttcctgtttt                                        30


<210> 681
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13103

<400> 681
gctgataaac cgatacaatt aaaggctcct                                        30


<210> 682
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13104

<400> 682
ctcttctcag cgtcttaatc taagctatcg                                        30


<210> 683
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13105

<400> 683
atgagccagt tcttaaaatc gcataaggta                                        30


<210> 684
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13106

<400> 684
ctattgattg tgacaaaata aacttattcc                                        30


<210> 685
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13108

<400> 685
gtttcgcgct tggtataatc gctgggggtc                                        30


<210> 686
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M13110

<400> 686
ctttgcttct gactataata gtcagggtaa                                        30


<210> 687
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M31519

<400> 687
aaaccgatac aattaaaggc tcctgctagc                                        30


<210> 688
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R1074

<400> 688
caccacactg atagtgctag tgtagatcac                                        30


<210> 689
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R1075

<400> 689
gccggaataa ctccctataa tgcgccacca                                        30


<210> 690
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_S03331

<400> 690
ttgacaagct tttcctcagc tccgtaaact                                        30


<210> 691
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J45992

<400> 691
ggtttcaaaa ttgtgatcta tatttaacaa                                        30


<210> 692
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J45993

<400> 692
ggtttcaaaa ttgtgatcta tatttaacaa                                        30


<210> 693
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J45504

<400> 693
tctattccaa taaagaaatc ttcctgcgtg                                        30


<210> 694
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1895002

<400> 694
gaccgaatat atagtggaaa cgtttagatg                                        30


<210> 695
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1895003

<400> 695
ccacatcctg tttttaacct taaaatggca                                        30


<210> 696
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K143012

<400> 696
aaaaatgggc tcgtgttgta caataaatgt                                        30


<210> 697
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K143013

<400> 697
aaaaaaagcg cgcgattatg taaaatataa                                        30


<210> 698
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K780003

<400> 698
aattgcagta ggcatgacaa aatggactca                                        30


<210> 699
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823000

<400> 699
caagcttttc ctttataata gaatgaatga                                        30


<210> 700
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823002

<400> 700
tctaagctag tgtattttgc gtttaatagt                                        30


<210> 701
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K823003

<400> 701
aatgggctcg tgttgtacaa taaatgtagt                                        30


<210> 702
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K143010

<400> 702
atccttatcg ttatgggtat tgtttgtaat                                        30


<210> 703
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K143011

<400> 703
taaaagaatt gtgagcggga atacaacaac                                        30


<210> 704
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K143013

<400> 704
aaaaaaagcg cgcgattatg taaaatataa                                        30


<210> 705
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K112706

<400> 705
tacaaaataa ttcccctgca aacattatca                                        30


<210> 706
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K112707

<400> 706
tacaaaataa ttcccctgca aacattatcg                                        30


<210> 707
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I712074

<400> 707
agggaataca agctacttgt tctttttgca                                        30


<210> 708
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I719005

<400> 708
taatacgact cactataggg aga                                               23


<210> 709
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J34814

<400> 709
gaatttaata cgactcacta tagggaga                                          28


<210> 710
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J64997

<400> 710
taatacgact cactatagg                                                    19


<210> 711
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K113010

<400> 711
gagtcgtatt aatacgactc actatagggg                                        30


<210> 712
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K113011

<400> 712
agtgagtcgt actacgactc actatagggg                                        30


<210> 713
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K113012

<400> 713
gagtcgtatt aatacgactc tctatagggg                                        30


<210> 714
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K1614000

<400> 714
taatacgact cactatag                                                     18


<210> 715
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R0085

<400> 715
taatacgact cactataggg aga                                               23


<210> 716
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R0180

<400> 716
ttatacgact cactataggg aga                                               23


<210> 717
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R0181

<400> 717
gaatacgact cactataggg aga                                               23


<210> 718
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R0182

<400> 718
taatacgtct cactataggg aga                                               23


<210> 719
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_R0183

<400> 719
tcatacgact cactataggg aga                                               23


<210> 720
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_Z0251

<400> 720
taatacgact cactataggg agaccacaac                                        30


<210> 721
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_Z0252

<400> 721
taattgaact cactaaaggg agaccacagc                                        30


<210> 722
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_Z0253

<400> 722
cgaagtaata cgactcacta ttagggaaga                                        30


<210> 723
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 723
atttaggtga cactataga                                                    19


<210> 724
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I766555

<400> 724
acaaacacaa atacacacac taaattaata                                        30


<210> 725
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I766556

<400> 725
ccaagcatac aatcaactat ctcatataca                                        30


<210> 726
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I766557

<400> 726
gatacaggat acagcggaaa caacttttaa                                        30


<210> 727
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J63005

<400> 727
tttcaagcta taccaagcat acaatcaact                                        30


<210> 728
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K105027

<400> 728
cctttgcagc ataaattact atacttctat                                        30


<210> 729
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K105028

<400> 729
cctttgcagc ataaattact atacttctat                                        30


<210> 730
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K105029

<400> 730
cctttgcagc ataaattact atacttctat                                        30


<210> 731
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K105030

<400> 731
cctttgcagc ataaattact atacttctat                                        30


<210> 732
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K105031

<400> 732
cctttgcagc ataaattact atacttctat                                        30


<210> 733
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K122000

<400> 733
ttatctactt tttacaacaa atataaaaca                                        30


<210> 734
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K124000

<400> 734
acaaacacaa atacacacac taaattaata                                        30


<210> 735
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K124002

<400> 735
gtttcgaata aacacacata aacaaacaaa                                        30


<210> 736
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K319005

<400> 736
ccaagcatac aatcaactat ctcatataca                                        30


<210> 737
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_M31201

<400> 737
accatcaaag gaagctttaa tcttctcata                                        30


<210> 738
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_I712004

<400> 738
agaacccact gcttactggc ttatcgaaat                                        30


<210> 739
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_K076017

<400> 739
ggccgttttt ggcttttttg ttagacgaag                                        30


<210> 740
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Plpp

<400> 740
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgcta                                                                  66


<210> 741
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> PapFAB46

<400> 741
aaaaagagta ttgacttcgc atctttttgt acctataata gattcattgc ta               52


<210> 742
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> PJ23101+UP element

<400> 742
ggaaaatttt tttaaaaaaa aaactttaca gctagctcag tcctaggtat tatgctagc        59


<210> 743
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> PJ23107+UP element

<400> 743
ggaaaatttt tttaaaaaaa aaactttacg gctagctcag ccctaggtat tatgctagc        59


<210> 744
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> PSYN23119

<400> 744
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaa                                                                    64


<210> 745
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PhoA

<400> 745
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala 
            20      


<210> 746
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PhoA

<400> 746
Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Thr Lys Ala 
            20  


<210> 747
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> OmpF

<400> 747
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala 
            20          


<210> 748
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> cvaC

<400> 748
Met Arg Thr Leu Thr Leu Asn Glu Leu Asp Ser Val Ser Gly Gly 
1               5                   10                  15  


<210> 749
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> TorA

<400> 749
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Thr Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Ala Gln Ala Ala 
        35                  40              


<210> 750
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> fdnG

<400> 750
Met Asp Val Ser Arg Arg Gln Phe Phe Lys Ile Cys Ala Gly Gly Met 
1               5                   10                  15      


Ala Gly Thr Thr Val Ala Ala Leu Gly Phe Ala Pro Lys Gln Ala Leu 
            20                  25                  30          


Ala 
    


<210> 751
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> dmsA

<400> 751
Met Lys Thr Lys Ile Pro Asp Ala Val Leu Ala Ala Glu Val Ser Arg 
1               5                   10                  15      


Arg Gly Leu Val Lys Thr Thr Ala Ile Gly Gly Leu Ala Met Ala Ser 
            20                  25                  30          


Ser Ala Leu Thr Leu Pro Phe Ser Arg Ile Ala His Ala 
        35                  40                  45  


<210> 752
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> PelB

<400> 752
Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Pro Ala Met Ala 
            20      


<210> 753
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> HlyA secretion signal

<400> 753
Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
1               5                   10                  15      


Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu 
            20                  25                  30          


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
        35                  40                  45              


Thr Ala Ser Ala 
    50          


<210> 754
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> HlyA secretion signal

<400> 754
cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtaa ttttgatgtt       60

aaagaggaaa gagctgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      120

tatggacgga actcaataac tttgacagca tcagcataa                             159


<210> 755
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> VH (10D1)

<400> 755
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc      300

tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 756
<211> 325
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> VL (10D1)

<400> 756
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttggc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcattca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210> 757
<211> 355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> VH (4B6)

<400> 757
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaagcaa taaacactac      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc      300

tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210> 758
<211> 325
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> VL (4B6)

<400> 758
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210> 759
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> VH (1E2)

<400> 759
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt tttactgtgc gagagctccc      300

aattatattg gtgcttttga tgtctggggc caagggacaa tggtcaccgt ctcttcag        358


<210> 760
<211> 322
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> VL (1E2)

<400> 760
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctccgac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210> 761
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Heavy chain (human monoclonal)

<400> 761
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210> 762
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Light chain (human monoclonal)

<400> 762
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 763
<211> 448
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Heavy chain (human monoclonal)

<400> 763
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210> 764
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Light chain (human monoclonal)

<400> 764
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 765
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti CTLA-4 scFv; Heavy Chain  linker  Light Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site


<400> 765
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210> 766
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti CTLA-4 scFv; Codon-optimized Heavy Chain  linker 
      Light Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site


<400> 766
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaaca aataaaaatg aggaggcaat tctaatgcaa      180

gtgcaactgg tagagtccgg tgggggcgtg gtgcagccgg gtcgcagcct gcgtctgtcg      240

tgcgcggcga gtggttttac gttttcgagt tatactatgc actgggttcg tcaagcgccg      300

ggcaaaggcc tggaatgggt tactttcatt tcttacgatg gtaataataa atattatgcg      360

gattctgtga aaggtcgctt tactatttcg cgcgataaca gtaaaaacac tctgtatctg      420

caaatgaatt ctctgcgtgc agaggatact gctatctatt actgcgcgcg tacgggctgg      480

ttgggcccgt ttgattattg gggccaaggc actttggtta ctgtgtcatc gggcgggggc      540

tctggcggtg gttcaggtgg tggcagtggt ggtggcgaga tcgtgttgac tcaatctccg      600

ggtactctgt ctctgtctcc gggtgaacgc gcgaccctgt cttgccgcgc ttctcagagt      660

gttggttcat cgtatctggc atggtatcaa cagaaaccgg gtcaagcgcc gcgtctgctg      720

atttacggtg cttttagtcg cgcaaccggg attccggatc gattttctgg ttcaggttct      780

ggcactgact ttactttgac tattagtcgt ctggaaccgg aggacttcgc ggtttattat      840

tgccaacagt atggttcttc tccgtggacc tttggtcaag gcactaaagt tgaaattaaa      900

taatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 767
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti CTLA-4 scFv; Light Chain  linker  Heavy Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site


<400> 767
Met Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser 
                165                 170                 175     


Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly 
    210                 215                 220                 


Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 768
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti CTLA-4 scFv; Codon-optimized Light Chain  linker 
      Heavy Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site


<400> 768
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaaca gattataagg agttaaatag aaaaatggag      180

attgtactga cccagagccc tggtacattg tctttgtcgc ctggtgaacg cgcgactctg      240

tcttgtcgtg cgtctcagtc tgttggtagt tcgtatctgg cgtggtatca acaaaaaccg      300

ggccaagctc cgcgtctgct gatttacggt gcatttagcc gcgcgactgg cattccggac      360

cgcttttctg ggtctggctc aggtaccgat tttactctga ctatttcgcg tctggagccg      420

gaggatttcg cggtttatta ctgccagcaa tatggttcta gtccgtggac cttcggccaa      480

ggtactaaag tggaaatcaa aggcgggggt tcgggtggtg gctctggggg tggctcgggc      540

ggtgggcagg tgcaactggt tgagagtggt ggcggcgttg ttcaaccggg ccgctctctg      600

cgcctgtcgt gcgctgcttc tggctttacc tttagctctt atacgatgca ctgggttcgc      660

caagctccgg gtaaaggtct ggagtgggtg actttcattt cttacgatgg taacaacaaa      720

tattatgctg attctgttaa aggccgtttt actatttctc gagacaatag caaaaacact      780

ctgtacctgc agatgaattc tctgcgcgct gaagacaccg cgatttatta ttgtgcgcgc      840

actggttggc tgggtccgtt tgattattgg ggtcagggca cgctggttac tgttagctcg      900

tgatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 769
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PD-1 scFv; Heavy Chain  linker  Light Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site


<400> 769
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn 
            20                  25                  30          


Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
    130                 135                 140                 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
                165                 170                 175     


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
        195                 200                 205             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
    210                 215                 220                 


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235     


<210> 770
<211> 1095
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PD-1 scFv; Codon-optimized Heavy Chain  linker  
      Light Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site


<400> 770
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaacc tcaaagaatt ataggaaagg aggaagcgat      180

aagtatgcag gtgcaattgg tggagtcggg tggcggcgtg gtgcaaccgg gtcgtagcct      240

gcgcctggat tgtaaagcgt caggcatcac gtttagcaat tctggcatgc actgggtgcg      300

tcaagcgccg ggcaaaggtc tggagtgggt tgcggtaatt tggtacgatg gttctaaacg      360

ctattacgcg gatagtgtga aaggtcgctt tactatctct cgcgataatt ctaaaaacac      420

cctgtttctg caaatgaatt cgttgcgtgc ggaagatact gcggtatatt attgtgctac      480

taacgatgat tattggggtc aaggcaccct ggtgactgtt tcgagcggcg gtggtagcgg      540

cggcggctct ggtggtggtt ctggtggcgg tgagattgtg ctgactcaaa gcccggcgac      600

cctgtctctg tcgccgggtg aacgcgctac tctgagttgc cgtgcgtcgc aaagcgtgtc      660

ttcttatctg gcgtggtacc aacaaaaacc gggtcaagcg ccgcgcctgc tgatatatga      720

tgctagtaat cgtgcaacgg gtattccggc acgcttttca ggttctggca gcggcaccga      780

tttcactctg actatctcgt cactggagcc ggaagacttt gcggtttatt attgtcagca      840

atcttctaat tggccgcgta cgtttggtca gggcactaaa gttgaaatca aataatcgcc      900

gtaacctgat taactgagac tgacggcaac gccaaattgc ctgatgcgct gcgcttatca      960

ggcctacaag gggaattgca atttattgaa tttgcacatt tttgtaggcc ggataaggcg     1020

tttacgccgc atccggcaac atgaatggta atttgccagc aacgtgcttc cccgccaacg     1080

gcggggtttt ttctg                                                      1095


<210> 771
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PD-1 scFv; Light Chain  linker  Heavy Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site


<400> 771
Met Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp 
    130                 135                 140                 


Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr 
                165                 170                 175     


Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
225                 230                 235     


<210> 772
<211> 1085
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PD-1 scFv; Codon-optimized Light Chain  linker  
      Heavy Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site


<400> 772
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaaca tcaccaattt gaggaaaggt aaatatggaa      180

atcgttttaa cgcagtcgcc ggcgactctg tctttgtcgc ctggtgaacg tgctacgctg      240

tcttgccgcg cgtcacagtc tgtgtcgtca tatctggctt ggtaccaaca gaaaccgggc      300

caagctccgc gcctgctgat ttatgatgcg tctaatcgcg cgaccggcat tccggcgcgt      360

ttttctggct ccggctctgg caccgacttt actctgacta tttcgtctct ggaaccggaa      420

gattttgcgg tgtactattg ccagcaatct tctaattggc cgcgcacgtt tggtcaaggt      480

accaaggttg agatcaaagg tggtggctcg ggcggcggtt cgggcggcgg ctcaggtggt      540

ggccaagttc agttggttga gtctggcggg ggcgtagtac aaccgggtcg ttctttgcgt      600

ctggattgca aagcgagcgg tattaccttt agcaattcag gtatgcactg ggtgcgccaa      660

gcgccgggca aaggcctgga atgggttgcg gtgatttggt acgatggctc gaaacgttat      720

tatgctgaca gcgttaaagg tcgttttact attagccgtg ataattccaa aaatacgctg      780

tttctgcaga tgaatagcct gcgtgctgaa gacactgcgg tttattactg tgctactaat      840

gatgattact ggggccaggg caccctggtg actgtgagtt cttaatcgcc gtaacctgat      900

taactgagac tgacggcaac gccaaattgc ctgatgcgct gcgcttatca ggcctacaag      960

gggaattgca atttattgaa tttgcacatt tttgtaggcc ggataaggcg tttacgccgc     1020

atccggcaac atgaatggta atttgccagc aacgtgcttc cccgccaacg gcggggtttt     1080

ttctg                                                                 1085


<210> 773
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PDL-1 scFv; Heavy Chain  linker  Light Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site


<400> 773
Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
            20                  25                  30          


Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210> 774
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PDL-1 scFv; Codon-optimized Heavy Chain  linker  
      Light Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site


<400> 774
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaact acataatttt ggggagggta ctcgatggaa      180

gttcagctgg tggagagtgg tggcggtctg gtgcagccgg gcggctctct gcgtctgagc      240

tgtgcggcgt ctggctttac gttttctgac agttggattc actgggtgcg ccaagcaccg      300

ggcaaaggcc tggagtgggt ggcgtggatt tctccgtatg gcggtagtac ttattatgct      360

gattctgtga aaggccgttt taccatttcg gcggacactt caaaaaatac cgcgtatctg      420

caaatgaata gcctgcgcgc tgaagacacg gctgtttact actgtgctcg ccgccactgg      480

ccgggcggtt tcgattattg gggccaaggc actctggtga ctgtgagctc tggcggcggg      540

tcgggtggcg gttctggcgg tggcagtggc ggtggtgata ttcaaatgac ccaatctccg      600

tcgtctctga gcgcgtctgt gggcgatcgt gtaaccatta cttgtcgtgc gtcgcaggat      660

gtgtctactg ctgtggcgtg gtatcagcaa aaaccgggta aagctccgaa actgctgatt      720

tatagcgctt cttttctgta tagtggtgtt ccgtcacgtt ttagcggttc aggctctggt      780

actgatttca cactgactat ttcttctctg caaccggaag atttcgcgac ttattattgt      840

cagcagtact tgtaccaccc ggcaactttt ggtcagggca ctaaagttga aattaaacgt      900

taatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 775
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PDL-1 scFv; Light Chain  linker  Heavy Chain 
      Transcribed from the native FliC promoter and 5UTR (untranslated 
      region) with an optimized ribosome binding site


<400> 775
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
                165                 170                 175     


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
    210                 215                 220                 


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 776
<211> 1103
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PDL-1 scFv; Codon-optimized Light Chain  linker  
      Heavy Chain Transcribed from the native FliC promoter and 5UTR 
      (untranslated region) with an optimized ribosome binding site


<400> 776
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggttgacgg cgattgagcc      120

gacgggtgga aacccaaaac gtaatcaact ggcagacgcc taaggaggaa gaccatggat      180

attcagatga ctcagagccc tagctcactg tctgcgtcag ttggcgatcg tgtgactatt      240

acctgtcgcg ctagtcagga tgtgtctacg gcggttgcgt ggtatcaaca gaaaccgggc      300

aaagctccga aactgttgat ttattcagcg tctttcctgt attcgggtgt gccttctcgc      360

ttttcgggct ctggtagcgg tactgatttt acgctgacta ttagttcact gcaaccggag      420

gactttgcga cttattattg ccaacaatac ctgtatcacc cggcgacctt tggtcaaggc      480

actaaagtgg aaattaaacg cggcggcggc agcggtggcg gctctggtgg tgggtctggt      540

ggtggtgagg ttcagctggt tgagtctggt ggtggtctgg ttcaacctgg gggcagcctg      600

cgcctgtcgt gcgcggcgtc tggttttacg ttctcagatt cttggattca ctgggtacgt      660

caagctccgg gcaaaggtct ggagtgggtg gcgtggattt ctccgtatgg cggttcgacg      720

tattacgcgg actctgttaa agggcgtttt acgatctcag cggatacttc taaaaatact      780

gcgtatctgc aaatgaattc tctgcgagcg gaggataccg cggtgtatta ctgtgctcgc      840

cgccactggc ctggtggttt cgattattgg ggtcaaggta ccctggtgac tgtttcgtct      900

taatcgccgt aacctgatta actgagactg acggcaacgc caaattgcct gatgcgctgc      960

gcttatcagg cctacaaggg gaattgcaat ttattgaatt tgcacatttt tgtaggccgg     1020

ataaggcgtt tacgccgcat ccggcaacat gaatggtaat ttgccagcaa cgtgcttccc     1080

cgccaacggc ggggtttttt ctg                                             1103


<210> 777
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti CTLA-4 scFv

<400> 777
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Gln Val Gln Leu Val 
    50                  55                  60                  


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser 
65                  70                  75                  80  


Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val 
                85                  90                  95      


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr 
            100                 105                 110         


Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        115                 120                 125             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    130                 135                 140                 


Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp 
145                 150                 155                 160 


Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                165                 170                 175     


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
        195                 200                 205             


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
    210                 215                 220                 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
225                 230                 235                 240 


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
            260                 265                 270         


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
        275                 280                 285             


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Phe Lys Ala Glu 
    290                 295                 300                 


Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe Met Asn Ala Gly 
305                 310                 315                 320 


Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn Lys Arg Met Gly 
                325                 330                 335     


Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp Ala Arg Ile Met 
            340                 345                 350         


Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His 
        355                 360                 365             


Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp Gly Val Asp Leu 
    370                 375                 380                 


Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser Ala Asp Ser His 
385                 390                 395                 400 


Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser 
                405                 410                 415     


Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile 
            420                 425                 430         


His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys 
        435                 440                 445             


His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg 
    450                 455                 460                 


Tyr His Leu Thr Glu Glu Thr Phe Ile Glu Pro Gln Ala Glu Leu Val 
465                 470                 475                 480 


Tyr Gly Ala Val Ser Gly Lys Thr Phe Arg Trp Lys Asp Gly Asp Met 
                485                 490                 495     


Asp Leu Ser Met Lys Asn Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr 
            500                 505                 510         


Gly Ile Glu Leu Gly Lys Thr Phe Ser Gly Lys Asp Trp Ser Val Thr 
        515                 520                 525             


Ala Arg Ala Gly Thr Ser Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu 
    530                 535                 540                 


Thr Val Leu Arg Asp Ala Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Asp Ser Arg Met Leu Phe Asn Val Gly Met Asn Ala Gln Ile Lys Asp 
                565                 570                 575     


Asn Met Arg Phe Gly Leu Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr 
            580                 585                 590         


Asn Val Asp Asn Ala Val Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600                 605     


<210> 778
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti CTLA-4 scFv

<400> 778
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcca      300

ggtacaatta gttgagagcg gcggcggtgt ggttcaaccg ggccgtagtc tgcgattgtc      360

ttgtgctgca tctggtttta ctttcagttc ttacacgatg cactgggttc gccaagctcc      420

gggcaaaggc ctggagtggg ttacctttat ttcttacgat ggcaataata agtattacgc      480

tgattctgtg aaaggtcgct ttactattag ccgagataac tctaaaaata ctctgtatct      540

gcaaatgaat tctctgcgtg cggaagatac tgcgatctat tattgtgcgc gtactggttg      600

gctgggcccg tttgattatt ggggccaagg cacgctggtt actgttagtt cgggcggcgg      660

ttctggtggc ggctctggtg gtggctctgg cggcggcgag attgtgctga ctcaatctcc      720

gggcacgctg tcactgtctc cgggtgaacg cgcgaccctg tcttgtcgcg cgagtcaaag      780

tgttggttct tcttatctgg cttggtatca gcaaaagcct ggtcaagcgc cgcgtctgtt      840

gatttatggc gcgttttcgc gcgcgactgg cattccggac cgattttctg gttctggttc      900

tggcactgat ttcactctga ccatttcacg cctggaaccg gaggattttg cggtgtacta      960

ttgccaacaa tatggctcat cgccgtggac gtttggccaa ggtactaaag ttgagattaa     1020

attcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 779
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti CTLA-4 scFv

<400> 779
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Glu Ile Val Leu Thr 
    50                  55                  60                  


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
65                  70                  75                  80  


Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr 
                85                  90                  95      


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe 
            100                 105                 110         


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        115                 120                 125             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    130                 135                 140                 


Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln 
145                 150                 155                 160 


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            180                 185                 190         


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        195                 200                 205             


Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys 
225                 230                 235                 240 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                245                 250                 255     


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            260                 265                 270         


Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp 
        275                 280                 285             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Lys Ala Glu 
    290                 295                 300                 


Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe Met Asn Ala Gly 
305                 310                 315                 320 


Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn Lys Arg Met Gly 
                325                 330                 335     


Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp Ala Arg Ile Met 
            340                 345                 350         


Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His 
        355                 360                 365             


Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp Gly Val Asp Leu 
    370                 375                 380                 


Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser Ala Asp Ser His 
385                 390                 395                 400 


Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser 
                405                 410                 415     


Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile 
            420                 425                 430         


His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys 
        435                 440                 445             


His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg 
    450                 455                 460                 


Tyr His Leu Thr Glu Glu Thr Phe Ile Glu Pro Gln Ala Glu Leu Val 
465                 470                 475                 480 


Tyr Gly Ala Val Ser Gly Lys Thr Phe Arg Trp Lys Asp Gly Asp Met 
                485                 490                 495     


Asp Leu Ser Met Lys Asn Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr 
            500                 505                 510         


Gly Ile Glu Leu Gly Lys Thr Phe Ser Gly Lys Asp Trp Ser Val Thr 
        515                 520                 525             


Ala Arg Ala Gly Thr Ser Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu 
    530                 535                 540                 


Thr Val Leu Arg Asp Ala Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Asp Ser Arg Met Leu Phe Asn Val Gly Met Asn Ala Gln Ile Lys Asp 
                565                 570                 575     


Asn Met Arg Phe Gly Leu Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr 
            580                 585                 590         


Asn Val Asp Asn Ala Val Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600                 605     


<210> 780
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti CTLA-4 scFv

<400> 780
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

aattgtactg acccagtcgc ctggtaccct gtctctgtcg ccgggtgaac gtgctaccct      360

gtcttgtcgt gcttcgcaat cggttggctc gtcttatctg gcatggtatc agcaaaaacc      420

gggccaagcg cctcgtctgc tgatttatgg cgcgttttct cgtgctacgg gcattcctga      480

tcgtttttcg ggctctggct ctggtactga ttttacgctg actatcagcc gcttggaacc      540

tgaagatttt gcggtttatt attgccaaca atatggctct tctccgtgga cgtttggtca      600

aggcactaaa gttgaaatta aaggtggtgg ctcgggcggt ggttctggtg gtggtagtgg      660

tggtggtcaa gtgcagttgg ttgaatcggg tggcggtgtt gtgcagccgg gccgttcgtt      720

gcgtctgtct tgcgcagcga gtggtttcac cttctcttct tatactatgc actgggtgcg      780

tcaagcacct ggcaaaggtc tggagtgggt aacttttatt tcatacgatg gtaataataa      840

atattatgca gattctgtta aaggtcgctt tacgatttct cgcgataatt caaaaaatac      900

gctgtatctg cagatgaatt cgctgcgcgc tgaggatact gcgatctact attgtgcgcg      960

tactggttgg ctgggtccgt ttgattactg gggccaaggt acgctggtta cagtttcgtc     1020

gttcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 781
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PD-1 scFv

<400> 781
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Gln Val Gln Leu Val 
    50                  55                  60                  


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp 
65                  70                  75                  80  


Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val 
                85                  90                  95      


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr 
            100                 105                 110         


Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        115                 120                 125             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
    130                 135                 140                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Glu Ile Val Leu Thr 
            180                 185                 190         


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
        195                 200                 205             


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
    210                 215                 220                 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
225                 230                 235                 240 


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                245                 250                 255     


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            260                 265                 270         


Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly 
        275                 280                 285             


Thr Lys Val Glu Ile Lys Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala 
    290                 295                 300                 


Ala Lys Ala Asp Ser Phe Met Asn Ala Gly Tyr Lys Asn Phe Met Thr 
305                 310                 315                 320 


Glu Val Asn Asn Leu Asn Lys Arg Met Gly Asp Leu Arg Asp Thr Asn 
                325                 330                 335     


Gly Asp Ala Gly Ala Trp Ala Arg Ile Met Ser Gly Ala Gly Ser Ala 
            340                 345                 350         


Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His Val Gln Val Gly Phe Asp 
        355                 360                 365             


Lys Lys His Glu Leu Asp Gly Val Asp Leu Phe Thr Gly Val Thr Met 
    370                 375                 380                 


Thr Tyr Thr Asp Ser Ser Ala Asp Ser His Ala Phe Ser Gly Lys Thr 
385                 390                 395                 400 


Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly 
                405                 410                 415     


Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile His His Asp Asn Asp Tyr 
            420                 425                 430         


Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys His Tyr Asn Thr His Ser 
        435                 440                 445             


Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg Tyr His Leu Thr Glu Glu 
    450                 455                 460                 


Thr Phe Ile Glu Pro Gln Ala Glu Leu Val Tyr Gly Ala Val Ser Gly 
465                 470                 475                 480 


Lys Thr Phe Arg Trp Lys Asp Gly Asp Met Asp Leu Ser Met Lys Asn 
                485                 490                 495     


Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr Gly Ile Glu Leu Gly Lys 
            500                 505                 510         


Thr Phe Ser Gly Lys Asp Trp Ser Val Thr Ala Arg Ala Gly Thr Ser 
        515                 520                 525             


Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu Thr Val Leu Arg Asp Ala 
    530                 535                 540                 


Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys Asp Ser Arg Met Leu Phe 
545                 550                 555                 560 


Asn Val Gly Met Asn Ala Gln Ile Lys Asp Asn Met Arg Phe Gly Leu 
                565                 570                 575     


Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr Asn Val Asp Asn Ala Val 
            580                 585                 590         


Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600 


<210> 782
<211> 2020
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PD-1 scFv

<400> 782
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcca      300

agtacaactg gttgaatccg gcggaggagt ggtgcaaccg ggccgcagtt tgcgtctgga      360

ttgtaaagct tcaggcatca ctttttctaa ttctggtatg cactgggttc gccaagctcc      420

gggtaaaggt ctggagtggg ttgcggtgat ctggtatgat ggttctaaac gatattatgc      480

ggatagtgtt aagggtcgtt ttactatttc tcgtgataat tctaagaaca ccttgtttct      540

gcagatgaat agtctgcgcg ctgaggatac tgcggtatat tattgtgcga ctaatgacga      600

ttattggggc caaggcacgc tggttaccgt gagctctggt ggtggttcgg gtggtggttc      660

tggtggtggg agcggcggtg gcgagatcgt tctgactcaa agcccggcga ctctgagtct      720

gagtccgggt gaacgtgcga ctctgagctg ccgtgcgtct cagagtgtgt cgagttatct      780

ggcgtggtac caacaaaaac cgggccaggc gccgcgactg ctgatttatg atgcttctaa      840

tcgtgcgact ggtattccgg cgcgctttag cggttctggc tcaggcactg acttcactct      900

gactatttct tcgctggaac cggaagattt tgcggtgtac tattgtcaac aatcatctaa      960

ttggcctcgt acgttcggtc aaggtacaaa agtggagata aaattcaaag cggaggctga     1020

caaggccgct gcagcaaaag ctgactcctt tatgaacgcg ggttacaaaa acttcatgac     1080

cgaggtaaat aatctcaata aacgtatggg tgatctgcgc gacactaatg gggatgcagg     1140

cgcatgggca cgcattatgt ctggtgcagg ttcggcggat ggcgggtatt ctgacaatta     1200

cactcatgtt caggtgggct tcgataaaaa acatgagctg gacggtgtgg atctgttcac     1260

tggcgtaacc atgacttata ctgattcaag cgcagacagc cacgcatttt caggtaaaac     1320

gaaatcagtt ggcggcggtc tgtatgcgag cgcactgttc gagagcggcg cctacattga     1380

tctaattggc aagtatattc accatgataa tgattacaca gggaactttg caggcctggg     1440

caccaaacac tataacacgc attcatggta cgctggcgca gaaaccggct atagatacca     1500

cctgaccgag gaaaccttta tcgaaccgca agcggaactg gtttacggtg cggtcagtgg     1560

caagaccttt cgttggaaag atggtgatat ggatctgtca atgaaaaacc gcgacttcag     1620

ccccttgatc ggccgcaccg gcattgagct gggcaaaacc ttctctggca aagattggtc     1680

tgttaccgcg cgtgcgggca cttcgtggca atttgatctg ctaaacaacg gtgagactgt     1740

actgcgtgat gcgagtggcg aaaaacgtat taaaggtgaa aaagatagta gaatgctatt     1800

caacgtgggc atgaatgcgc agatcaaaga taacatgcgt tttgggttgg agtttgaaaa     1860

atccgcgttc ggtaaatata atgttgacaa tgctgtgaac gcgaatttcc gctacatgtt     1920

ttaactctaa cggacttgag tgaggttgta aagggagttg gctcctcggt accaaattcc     1980

agaaaagagg cctcccgaaa ggggggcctt ttttcgtttt                           2020


<210> 783
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PD-1 scFv

<400> 783
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Glu Ile Val Leu Thr 
    50                  55                  60                  


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
65                  70                  75                  80  


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                85                  90                  95      


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            100                 105                 110         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        115                 120                 125             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    130                 135                 140                 


Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly 
145                 150                 155                 160 


Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            180                 185                 190         


Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile 
        195                 200                 205             


Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                245                 250                 255     


Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            260                 265                 270         


Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala 
    290                 295                 300                 


Ala Lys Ala Asp Ser Phe Met Asn Ala Gly Tyr Lys Asn Phe Met Thr 
305                 310                 315                 320 


Glu Val Asn Asn Leu Asn Lys Arg Met Gly Asp Leu Arg Asp Thr Asn 
                325                 330                 335     


Gly Asp Ala Gly Ala Trp Ala Arg Ile Met Ser Gly Ala Gly Ser Ala 
            340                 345                 350         


Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His Val Gln Val Gly Phe Asp 
        355                 360                 365             


Lys Lys His Glu Leu Asp Gly Val Asp Leu Phe Thr Gly Val Thr Met 
    370                 375                 380                 


Thr Tyr Thr Asp Ser Ser Ala Asp Ser His Ala Phe Ser Gly Lys Thr 
385                 390                 395                 400 


Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly 
                405                 410                 415     


Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile His His Asp Asn Asp Tyr 
            420                 425                 430         


Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys His Tyr Asn Thr His Ser 
        435                 440                 445             


Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg Tyr His Leu Thr Glu Glu 
    450                 455                 460                 


Thr Phe Ile Glu Pro Gln Ala Glu Leu Val Tyr Gly Ala Val Ser Gly 
465                 470                 475                 480 


Lys Thr Phe Arg Trp Lys Asp Gly Asp Met Asp Leu Ser Met Lys Asn 
                485                 490                 495     


Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr Gly Ile Glu Leu Gly Lys 
            500                 505                 510         


Thr Phe Ser Gly Lys Asp Trp Ser Val Thr Ala Arg Ala Gly Thr Ser 
        515                 520                 525             


Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu Thr Val Leu Arg Asp Ala 
    530                 535                 540                 


Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys Asp Ser Arg Met Leu Phe 
545                 550                 555                 560 


Asn Val Gly Met Asn Ala Gln Ile Lys Asp Asn Met Arg Phe Gly Leu 
                565                 570                 575     


Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr Asn Val Asp Asn Ala Val 
            580                 585                 590         


Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600 


<210> 784
<211> 2020
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PD-1 scFv

<400> 784
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

aatcgtgctg actcagagtc cggcgactct gtctctgagt ccgggcgaac gcgcgactct      360

gtcttgccgt gcgtctcaat ctgtgtcttc atacttggct tggtaccaac aaaaaccggg      420

ccaggcgccg cgactgttga tttatgatgc gtcgaatcgc gcgactggca ttccggcgcg      480

cttttcgggt agcggttctg gtactgattt tacgctgact atctcttctc tggagcctga      540

agatttcgct gtttattact gccaacagtc tagtaattgg ccgcgtactt tcggccaggg      600

cactaaggtg gaaattaaag gtggcggctc gggcggcggc tcgggtggtg gttctggtgg      660

tggccaagtg caactggtgg aaagtggcgg cggggtggtg caaccgggcc gttctctgcg      720

cctggattgt aaagcttcag gcattacttt tagcaactct ggtatgcact gggttcgcca      780

agctccgggc aaaggcctgg aatgggtggc ggttatttgg tacgatggct ctaaacgtta      840

ttacgctgac agtgttaaag gccgctttac catttctcgt gataattcta aaaataccct      900

gtttctgcaa atgaactcgc tgcgcgcgga agatactgct gtttactatt gtgcgactaa      960

tgatgattac tggggtcaag gtaccctggt taccgtgtct tctttcaaag cggaggctga     1020

caaggccgct gcagcaaaag ctgactcctt tatgaacgcg ggttacaaaa acttcatgac     1080

cgaggtaaat aatctcaata aacgtatggg tgatctgcgc gacactaatg gggatgcagg     1140

cgcatgggca cgcattatgt ctggtgcagg ttcggcggat ggcgggtatt ctgacaatta     1200

cactcatgtt caggtgggct tcgataaaaa acatgagctg gacggtgtgg atctgttcac     1260

tggcgtaacc atgacttata ctgattcaag cgcagacagc cacgcatttt caggtaaaac     1320

gaaatcagtt ggcggcggtc tgtatgcgag cgcactgttc gagagcggcg cctacattga     1380

tctaattggc aagtatattc accatgataa tgattacaca gggaactttg caggcctggg     1440

caccaaacac tataacacgc attcatggta cgctggcgca gaaaccggct atagatacca     1500

cctgaccgag gaaaccttta tcgaaccgca agcggaactg gtttacggtg cggtcagtgg     1560

caagaccttt cgttggaaag atggtgatat ggatctgtca atgaaaaacc gcgacttcag     1620

ccccttgatc ggccgcaccg gcattgagct gggcaaaacc ttctctggca aagattggtc     1680

tgttaccgcg cgtgcgggca cttcgtggca atttgatctg ctaaacaacg gtgagactgt     1740

actgcgtgat gcgagtggcg aaaaacgtat taaaggtgaa aaagatagta gaatgctatt     1800

caacgtgggc atgaatgcgc agatcaaaga taacatgcgt tttgggttgg agtttgaaaa     1860

atccgcgttc ggtaaatata atgttgacaa tgctgtgaac gcgaatttcc gctacatgtt     1920

ttaactctaa cggacttgag tgaggttgta aagggagttg gctcctcggt accaaattcc     1980

agaaaagagg cctcccgaaa ggggggcctt ttttcgtttt                           2020


<210> 785
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PDL-1 scFv

<400> 785
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Asp Ile Gln Met Thr 
    50                  55                  60                  


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
65                  70                  75                  80  


Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln 
                85                  90                  95      


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
            100                 105                 110         


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        115                 120                 125             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    130                 135                 140                 


Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly 
145                 150                 155                 160 


Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            180                 185                 190         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        195                 200                 205             


Phe Thr Phe Ser Asp Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly 
    210                 215                 220                 


Lys Gly Leu Glu Trp Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr 
225                 230                 235                 240 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
                245                 250                 255     


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            260                 265                 270         


Thr Ala Val Tyr Tyr Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp 
        275                 280                 285             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Phe Lys Ala Glu 
    290                 295                 300                 


Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe Met Asn Ala Gly 
305                 310                 315                 320 


Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn Lys Arg Met Gly 
                325                 330                 335     


Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp Ala Arg Ile Met 
            340                 345                 350         


Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His 
        355                 360                 365             


Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp Gly Val Asp Leu 
    370                 375                 380                 


Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser Ala Asp Ser His 
385                 390                 395                 400 


Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser 
                405                 410                 415     


Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile 
            420                 425                 430         


His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys 
        435                 440                 445             


His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg 
    450                 455                 460                 


Tyr His Leu Thr Glu Glu Thr Phe Ile Glu Pro Gln Ala Glu Leu Val 
465                 470                 475                 480 


Tyr Gly Ala Val Ser Gly Lys Thr Phe Arg Trp Lys Asp Gly Asp Met 
                485                 490                 495     


Asp Leu Ser Met Lys Asn Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr 
            500                 505                 510         


Gly Ile Glu Leu Gly Lys Thr Phe Ser Gly Lys Asp Trp Ser Val Thr 
        515                 520                 525             


Ala Arg Ala Gly Thr Ser Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu 
    530                 535                 540                 


Thr Val Leu Arg Asp Ala Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys 
545                 550                 555                 560 


Asp Ser Arg Met Leu Phe Asn Val Gly Met Asn Ala Gln Ile Lys Asp 
                565                 570                 575     


Asn Met Arg Phe Gly Leu Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr 
            580                 585                 590         


Asn Val Asp Asn Ala Val Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600                 605     


<210> 786
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PDL-1 scFv

<400> 786
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

agtgcagctg gtggagtcag gtggaggctt ggtgcaaccg ggcggttcac tgcgtctgtc      360

atgtgcggcg tctgggttta cttttagtga ctcttggatt cactgggtgc gccaggctcc      420

gggtaaaggc ctggaatggg tagcttggat tagtccttac ggtggctcga cctattatgc      480

tgattcggta aagggtcgct ttactattag cgctgatact tctaaaaata ctgcatacct      540

gcagatgaat agcctgcgcg ctgaggatac tgctgtgtat tattgcgcgc gtcgccactg      600

gccgggcggc tttgattatt ggggccaagg tactctggtt accgtgtcta gtggcggtgg      660

tagcggcggc ggctcaggtg gcggctcggg cggtggcgac attcagatga ctcagtctcc      720

gtcttctttg tcggcgagcg tgggcgatcg tgttaccatc acgtgtcgcg cgagccaaga      780

tgtgtcgact gcggtggctt ggtatcaaca aaaaccgggt aaagctccga aactgctgat      840

ttatagtgcg tcttttttgt attctggtgt tccgtctcgt ttctctggct caggtagcgg      900

tactgatttt acgctgacta tttcttcact gcaaccggaa gattttgcta cgtattattg      960

tcaacaatat ctgtatcacc cggcgacgtt tggtcagggt actaaggtgg agataaaacg     1020

cttcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 787
<211> 600
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PDL-1 scFv

<400> 787
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg Glu Ile Val Leu Thr 
    50                  55                  60                  


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
65                  70                  75                  80  


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
                85                  90                  95      


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn 
            100                 105                 110         


Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        115                 120                 125             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    130                 135                 140                 


Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly 
145                 150                 155                 160 


Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val 
            180                 185                 190         


Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile 
        195                 200                 205             


Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
    210                 215                 220                 


Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr 
225                 230                 235                 240 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                245                 250                 255     


Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            260                 265                 270         


Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr 
        275                 280                 285             


Leu Val Thr Val Ser Ser Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala 
    290                 295                 300                 


Ala Lys Ala Asp Ser Phe Met Asn Ala Gly Tyr Lys Asn Phe Met Thr 
305                 310                 315                 320 


Glu Val Asn Asn Leu Asn Lys Arg Met Gly Asp Leu Arg Asp Thr Asn 
                325                 330                 335     


Gly Asp Ala Gly Ala Trp Ala Arg Ile Met Ser Gly Ala Gly Ser Ala 
            340                 345                 350         


Asp Gly Gly Tyr Ser Asp Asn Tyr Thr His Val Gln Val Gly Phe Asp 
        355                 360                 365             


Lys Lys His Glu Leu Asp Gly Val Asp Leu Phe Thr Gly Val Thr Met 
    370                 375                 380                 


Thr Tyr Thr Asp Ser Ser Ala Asp Ser His Ala Phe Ser Gly Lys Thr 
385                 390                 395                 400 


Lys Ser Val Gly Gly Gly Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly 
                405                 410                 415     


Ala Tyr Ile Asp Leu Ile Gly Lys Tyr Ile His His Asp Asn Asp Tyr 
            420                 425                 430         


Thr Gly Asn Phe Ala Gly Leu Gly Thr Lys His Tyr Asn Thr His Ser 
        435                 440                 445             


Trp Tyr Ala Gly Ala Glu Thr Gly Tyr Arg Tyr His Leu Thr Glu Glu 
    450                 455                 460                 


Thr Phe Ile Glu Pro Gln Ala Glu Leu Val Tyr Gly Ala Val Ser Gly 
465                 470                 475                 480 


Lys Thr Phe Arg Trp Lys Asp Gly Asp Met Asp Leu Ser Met Lys Asn 
                485                 490                 495     


Arg Asp Phe Ser Pro Leu Ile Gly Arg Thr Gly Ile Glu Leu Gly Lys 
            500                 505                 510         


Thr Phe Ser Gly Lys Asp Trp Ser Val Thr Ala Arg Ala Gly Thr Ser 
        515                 520                 525             


Trp Gln Phe Asp Leu Leu Asn Asn Gly Glu Thr Val Leu Arg Asp Ala 
    530                 535                 540                 


Ser Gly Glu Lys Arg Ile Lys Gly Glu Lys Asp Ser Arg Met Leu Phe 
545                 550                 555                 560 


Asn Val Gly Met Asn Ala Gln Ile Lys Asp Asn Met Arg Phe Gly Leu 
                565                 570                 575     


Glu Phe Glu Lys Ser Ala Phe Gly Lys Tyr Asn Val Asp Asn Ala Val 
            580                 585                 590         


Asn Ala Asn Phe Arg Tyr Met Phe 
        595                 600 


<210> 788
<211> 2038
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PDL-1 scFv

<400> 788
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattaa atatcaacta gaggtcacca      120

aatgaacaaa gtatatagcc tgaaatattg cccagtaact gggggtctga ttgtagtcag      180

tgaactggca tcccgcgtca tcaaaaaaac ctgccgtcgt ctgactcaca tcctgctggc      240

gggtattccg gctgtgtatc tgtactaccc gcagatctcc caggcaggta tcgtccgcga      300

tattcaaatg actcaatctc cgagctctct gagtgcgtct gtgggtgatc gtgtgactat      360

tacttgtcgt gcgtctcaag atgtttcaac tgcggttgcg tggtatcaac agaaaccggg      420

caaggcgcct aagctgctga tttattctgc ttcgttcctg tacagcggtg tgccgtctcg      480

tttctctggc tctggttcgg gtactgattt cactctgact atttcgagtc tgcagccgga      540

agattttgcg acttattatt gtcaacaata tctgtatcac cctgcgacgt ttggtcaagg      600

cacgaaagtt gaaattaaac gtggtggtgg ctctggtggt ggcagcggtg gtgggtcggg      660

tggcggtgaa gttcaactgg ttgagtcagg tggtggcctg gtgcaaccgg gcggctctct      720

gcgcctgtct tgtgctgcgt cgggttttac gttctctgat agctggattc actgggtacg      780

ccaggcaccg ggcaaaggtc tggaatgggt agcttggatt tcaccttatg gtggctctac      840

ttattacgcg gatagcgtga aaggtcgctt tactatttct gcggacacta gcaaaaatac      900

tgcttacctg caaatgaatt cgctgcgtgc tgaggatact gcagtgtatt actgtgcgcg      960

tcgtcattgg cctggcggct ttgattattg gggtcaaggt actctggtta ctgttagcag     1020

cttcaaagcg gaggctgaca aggccgctgc agcaaaagct gactccttta tgaacgcggg     1080

ttacaaaaac ttcatgaccg aggtaaataa tctcaataaa cgtatgggtg atctgcgcga     1140

cactaatggg gatgcaggcg catgggcacg cattatgtct ggtgcaggtt cggcggatgg     1200

cgggtattct gacaattaca ctcatgttca ggtgggcttc gataaaaaac atgagctgga     1260

cggtgtggat ctgttcactg gcgtaaccat gacttatact gattcaagcg cagacagcca     1320

cgcattttca ggtaaaacga aatcagttgg cggcggtctg tatgcgagcg cactgttcga     1380

gagcggcgcc tacattgatc taattggcaa gtatattcac catgataatg attacacagg     1440

gaactttgca ggcctgggca ccaaacacta taacacgcat tcatggtacg ctggcgcaga     1500

aaccggctat agataccacc tgaccgagga aacctttatc gaaccgcaag cggaactggt     1560

ttacggtgcg gtcagtggca agacctttcg ttggaaagat ggtgatatgg atctgtcaat     1620

gaaaaaccgc gacttcagcc ccttgatcgg ccgcaccggc attgagctgg gcaaaacctt     1680

ctctggcaaa gattggtctg ttaccgcgcg tgcgggcact tcgtggcaat ttgatctgct     1740

aaacaacggt gagactgtac tgcgtgatgc gagtggcgaa aaacgtatta aaggtgaaaa     1800

agatagtaga atgctattca acgtgggcat gaatgcgcag atcaaagata acatgcgttt     1860

tgggttggag tttgaaaaat ccgcgttcgg taaatataat gttgacaatg ctgtgaacgc     1920

gaatttccgc tacatgtttt aactctaacg gacttgagtg aggttgtaaa gggagttggc     1980

tcctcggtac caaattccag aaaagaggcc tcccgaaagg ggggcctttt ttcgtttt       2038


<210> 789
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti CTLA-4 scFv

<400> 789
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 790
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti CTLA-4 scFv

<400> 790
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aatacgattt      720

aattcggagg ttttttgatg caggtacaat tagttgagag cggcggcggt gtggttcaac      780

cgggccgtag tctgcgattg tcttgtgctg catctggttt tactttcagt tcttacacga      840

tgcactgggt tcgccaagct ccgggcaaag gcctggagtg ggttaccttt atttcttacg      900

atggcaataa taagtattac gctgattctg tgaaaggtcg ctttactatt agccgagata      960

actctaaaaa tactctgtat ctgcaaatga attctctgcg tgcggaagat actgcgatct     1020

attattgtgc gcgtactggt tggctgggcc cgtttgatta ttggggccaa ggcacgctgg     1080

ttactgttag ttcgggcggc ggttctggtg gcggctctgg tggtggctct ggcggcggcg     1140

agattgtgct gactcaatct ccgggcacgc tgtcactgtc tccgggtgaa cgcgcgaccc     1200

tgtcttgtcg cgcgagtcaa agtgttggtt cttcttatct ggcttggtat cagcaaaagc     1260

ctggtcaagc gccgcgtctg ttgatttatg gcgcgttttc gcgcgcgact ggcattccgg     1320

accgattttc tggttctggt tctggcactg atttcactct gaccatttca cgcctggaac     1380

cggaggattt tgcggtgtac tattgccaac aatatggctc atcgccgtgg acgtttggcc     1440

aaggtactaa agttgagatt aaacttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 791
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti CTLA-4 scFv

<400> 791
Met Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 
                85                  90                  95      


Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser 
                165                 170                 175     


Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly 
    210                 215                 220                 


Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 792
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti CTLA-4 scFv

<400> 792
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aatcacaacg      720

ctgagagaga gagaaatatg gaaattgtac tgacccagtc gcctggtacc ctgtctctgt      780

cgccgggtga acgtgctacc ctgtcttgtc gtgcttcgca atcggttggc tcgtcttatc      840

tggcatggta tcagcaaaaa ccgggccaag cgcctcgtct gctgatttat ggcgcgtttt      900

ctcgtgctac gggcattcct gatcgttttt cgggctctgg ctctggtact gattttacgc      960

tgactatcag ccgcttggaa cctgaagatt ttgcggttta ttattgccaa caatatggct     1020

cttctccgtg gacgtttggt caaggcacta aagttgaaat taaaggtggt ggctcgggcg     1080

gtggttctgg tggtggtagt ggtggtggtc aagtgcagtt ggttgaatcg ggtggcggtg     1140

ttgtgcagcc gggccgttcg ttgcgtctgt cttgcgcagc gagtggtttc accttctctt     1200

cttatactat gcactgggtg cgtcaagcac ctggcaaagg tctggagtgg gtaactttta     1260

tttcatacga tggtaataat aaatattatg cagattctgt taaaggtcgc tttacgattt     1320

ctcgcgataa ttcaaaaaat acgctgtatc tgcagatgaa ttcgctgcgc gctgaggata     1380

ctgcgatcta ctattgtgcg cgtactggtt ggctgggtcc gtttgattac tggggccaag     1440

gtacgctggt tacagtttcg tcgcttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 793
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PD-1 scFv

<400> 793
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn 
            20                  25                  30          


Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
    130                 135                 140                 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
145                 150                 155                 160 


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
                165                 170                 175     


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
        195                 200                 205             


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
    210                 215                 220                 


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Leu Asn Pro Leu 
225                 230                 235                 240 


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Asn Phe Asp Val 
                245                 250                 255     


Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala 
            260                 265                 270         


Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Ala Ser Ala 
        275                 280                 285             


<210> 794
<211> 5291
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PD-1 scFv

<400> 794
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aagttaaatt      720

gaggaggagg cagttccatg caagtacaac tggttgaatc cggcggagga gtggtgcaac      780

cgggccgcag tttgcgtctg gattgtaaag cttcaggcat cactttttct aattctggta      840

tgcactgggt tcgccaagct ccgggtaaag gtctggagtg ggttgcggtg atctggtatg      900

atggttctaa acgatattat gcggatagtg ttaagggtcg ttttactatt tctcgtgata      960

attctaagaa caccttgttt ctgcagatga atagtctgcg cgctgaggat actgcggtat     1020

attattgtgc gactaatgac gattattggg gccaaggcac gctggttacc gtgagctctg     1080

gtggtggttc gggtggtggt tctggtggtg ggagcggcgg tggcgagatc gttctgactc     1140

aaagcccggc gactctgagt ctgagtccgg gtgaacgtgc gactctgagc tgccgtgcgt     1200

ctcagagtgt gtcgagttat ctggcgtggt accaacaaaa accgggccag gcgccgcgac     1260

tgctgattta tgatgcttct aatcgtgcga ctggtattcc ggcgcgcttt agcggttctg     1320

gctcaggcac tgacttcact ctgactattt cttcgctgga accggaagat tttgcggtgt     1380

actattgtca acaatcatct aattggcctc gtacgttcgg tcaaggtaca aaagtggaga     1440

taaaacttaa tccattaatt aatgaaatca gcaaaatcat ttcagctgca ggtaattttg     1500

atgttaaaga ggaaagagct gcagcttctt tattgcagtt gtccggtaat gccagtgatt     1560

tttcatatgg acggaactca ataactttga cagcatcagc ataatttatt aatttaaata     1620

atagcaatct tactgggctg tgccacataa gattgctatt tttttggagt cataatggat     1680

tcttgtcata aaattgatta tgggttatac gccctggaga ttttagccca ataccataac     1740

gtctctgtta acccggaaga aattaaacat agatttgaca cagacgggac tggtctggga     1800

ttaacgtcat ggttgcttgc tgcgaaatct ttagaactaa aggtaaaaca ggtaaaaaaa     1860

acaattgacc gattaaactt tatttctttg cccgcattag tctggagaga ggatggacgt     1920

cattttattc tgactaaagt cagtaaagaa gcaaacagat atcttatttt tgatctggag     1980

caacgaaatc cccgtgttct cgaacagtct gagtttgagg cgttatatca ggggcatatt     2040

attcttattg cttcccgttc ttctgttacc gggaaactgg caaaatttga ctttacctgg     2100

tttatccctg ccattataaa atacagaaaa atatttattg aaacccttgt tgtatctgtt     2160

tttttacaat tatttgcatt aataaccccc cttttttttc aggtggttat ggacaaagta     2220

ttagtacaca gggggttttc aacccttaat gttattactg tcgcattatc tgttgtggtg     2280

gtgtttgaga ttatactcag cggtttaaga acttacattt ttgcacatag tacaagtcgg     2340

attgatgttg agttgggtgc caaactcttc cggcatttac tggcgctacc gatctcttat     2400

tttgagagtc gtcgtgttgg tgatactgtt gccagggtaa gagaattaga ccagatccgt     2460

aattttctga caggacaggc attaacatct gttctggact tattattttc attcatattt     2520

tttgcggtaa tgtggtatta cagcccaaag cttactctgg tgatcttatt ttcgctgccc     2580

tgttatgctg catggtctgt ttttattagc cccattttgc gacgtcgcct tgatgataag     2640

ttttcacgga atgcggataa tcaatctttc ctggtggaat cagtcacggc gattaacact     2700

ataaaagcta tggcagtctc acctcagatg acgaacatat gggacaaaca attggcagga     2760

tatgttgctg caggctttaa agtgacagta ttagccacca ttggtcaaca aggaatacag     2820

ttaatacaaa agactgttat gatcatcaac ctgtggttgg gagcacacct ggttatttcc     2880

ggggatttaa gtattggtca gttaattgct tttaatatgc ttgctggtca gattgttgca     2940

ccggttattc gccttgcaca aatctggcag gatttccagc aggttggtat atcagttacc     3000

cgccttggtg atgtgcttaa ctctccaact gaaagttatc atgggaaact ggcattaccg     3060

gaaattaatg gtaatatcac ttttcgtaat atccggtttc gctataagcc tgactctccg     3120

gttattttag ataatatcaa tctcagtatt aagcaggggg aggttattgg tattgtcgga     3180

cgttctggtt caggaaaaag cacattaact aaattaattc aacgttttta tattcctgaa     3240

aatggccagg tcttaattga tggacatgat cttgcgttgg ccgatcctaa ctggttacgt     3300

cgtcaggtgg gggttgtgtt gcaggacaat gtgctgctta atcgcagtat tattgataat     3360

atctcactgg ctaatcctgg tatgtccgtc gaaaaagtta tttatgcagc gaaattagca     3420

ggcgctcatg attttatttc tgaattgcgt gaggggtata acaccattgt cggggaacag     3480

ggggcaggat tatccggagg tcaacgtcaa cgcatcgcaa ttgcaagggc gctggtgaac     3540

aaccctaaaa tacttatttt tgatgaagca accagtgctc tggattatga gtcggagcat     3600

atcatcatgc gcaatatgca caaaatatgt aagggcagaa cggttataat cattgctcat     3660

cgtctgtcta cagtaaaaaa tgcagaccgc attattgtca tggaaaaagg gaaaattgtt     3720

gaacagggta aacataagga actgctttct gaaccggaaa gtttatacag ttacttatat     3780

cagttacagt cagactaaca gaaagaacag aagaatatga aaacatggtt aatggggttc     3840

agcgagttcc tgttgcgcta taaacttgtc tggagtgaaa catggaaaat ccggaagcaa     3900

ttagatactc cggtacgtga aaaggacgaa aatgaattct tacccgctca tctggaatta     3960

attgaaacgc cggtatccag acggccgcgt ctggttgctt attttattat ggggtttctg     4020

gttattgctg tcattttatc tgttttaggt caggtggaaa ttgttgccac tgcaaatggg     4080

aaattaacac taagtgggcg cagcaaagaa attaaaccta ttgaaaactc aatagttaaa     4140

gaaattatcg taaaagaagg agagtcagtc cggaaagggg atgtgttatt aaagcttaca     4200

gcactgggag ctgaagctga tacgttaaaa acacagtcat cactgttaca gaccaggctg     4260

gaacaaactc ggtatcaaat tctgagcagg tcaattgaat taaataaact acctgaactg     4320

aagcttcctg atgagcctta ttttcagaat gtatctgaag aggaagtact gcgtttaact     4380

tctttgataa aagaacagtt ttccacatgg caaaatcaga agtatcaaaa agaactgaat     4440

ctggataaga aaagagcaga gcgattaaca atacttgccc gtataaaccg ttatgaaaat     4500

ttatcgagag ttgaaaaaag ccgtctggat gatttcagga gtttattgca taaacaggca     4560

attgcaaaac atgctgtact tgagcaggag aataaatatg tcgaggcagc aaatgaatta     4620

cgggtttata aatcgcaact ggagcaaatt gagagtgaga tattgtctgc aaaagaagaa     4680

tatcagcttg tcacgcagct ttttaaaaat gaaattttag acaagctaag acaaacaaca     4740

gacaacattg agttattaac tctggagtta gagaaaaatg aagagcgtca acaggcttca     4800

gtaatcaggg cccctgtttc gggaaaagtt cagcaactga aggttcatac tgaaggtggg     4860

gttgttacaa cagcggaaac actgatggtc atcgttccgg aagatgacac gctggaggtt     4920

actgctctgg tacaaaataa agatattggt tttattaacg tcgggcagaa tgccatcatt     4980

aaagtggagg cctttcctta cacccgatat ggttatctgg tgggtaaggt gaaaaatata     5040

aatttagatg caatagaaga ccagaaactg ggactcgttt ttaatgtcat tgtttctgtt     5100

gaagagaatg atttgtcaac cgggaataag cacattccat taagctcggg tatggctgtc     5160

actgcagaaa taaagactgg aatgcgaagc gtaatcagct atcttcttag tcctctggaa     5220

gagtctgtaa cagaaagttt acatgagcgt taagtctcag agccgcggta tccggctcat     5280

atcttctcct g                                                          5291


<210> 795
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PD-1 scFv

<400> 795
Met Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
1               5                   10                  15      


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gln Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp 
    130                 135                 140                 


Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr 
                165                 170                 175     


Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            180                 185                 190         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp 
    210                 215                 220                 


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Leu Asn Pro Leu 
225                 230                 235                 240 


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Asn Phe Asp Val 
                245                 250                 255     


Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala 
            260                 265                 270         


Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Ala Ser Ala 
        275                 280                 285             


<210> 796
<211> 5291
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PD-1 scFv

<400> 796
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aatataccga      720

acgcttaagg aggctttatg gaaatcgtgc tgactcagag tccggcgact ctgtctctga      780

gtccgggcga acgcgcgact ctgtcttgcc gtgcgtctca atctgtgtct tcatacttgg      840

cttggtacca acaaaaaccg ggccaggcgc cgcgactgtt gatttatgat gcgtcgaatc      900

gcgcgactgg cattccggcg cgcttttcgg gtagcggttc tggtactgat tttacgctga      960

ctatctcttc tctggagcct gaagatttcg ctgtttatta ctgccaacag tctagtaatt     1020

ggccgcgtac tttcggccag ggcactaagg tggaaattaa aggtggcggc tcgggcggcg     1080

gctcgggtgg tggttctggt ggtggccaag tgcaactggt ggaaagtggc ggcggggtgg     1140

tgcaaccggg ccgttctctg cgcctggatt gtaaagcttc aggcattact tttagcaact     1200

ctggtatgca ctgggttcgc caagctccgg gcaaaggcct ggaatgggtg gcggttattt     1260

ggtacgatgg ctctaaacgt tattacgctg acagtgttaa aggccgcttt accatttctc     1320

gtgataattc taaaaatacc ctgtttctgc aaatgaactc gctgcgcgcg gaagatactg     1380

ctgtttacta ttgtgcgact aatgatgatt actggggtca aggtaccctg gttaccgtgt     1440

cttctcttaa tccattaatt aatgaaatca gcaaaatcat ttcagctgca ggtaattttg     1500

atgttaaaga ggaaagagct gcagcttctt tattgcagtt gtccggtaat gccagtgatt     1560

tttcatatgg acggaactca ataactttga cagcatcagc ataatttatt aatttaaata     1620

atagcaatct tactgggctg tgccacataa gattgctatt tttttggagt cataatggat     1680

tcttgtcata aaattgatta tgggttatac gccctggaga ttttagccca ataccataac     1740

gtctctgtta acccggaaga aattaaacat agatttgaca cagacgggac tggtctggga     1800

ttaacgtcat ggttgcttgc tgcgaaatct ttagaactaa aggtaaaaca ggtaaaaaaa     1860

acaattgacc gattaaactt tatttctttg cccgcattag tctggagaga ggatggacgt     1920

cattttattc tgactaaagt cagtaaagaa gcaaacagat atcttatttt tgatctggag     1980

caacgaaatc cccgtgttct cgaacagtct gagtttgagg cgttatatca ggggcatatt     2040

attcttattg cttcccgttc ttctgttacc gggaaactgg caaaatttga ctttacctgg     2100

tttatccctg ccattataaa atacagaaaa atatttattg aaacccttgt tgtatctgtt     2160

tttttacaat tatttgcatt aataaccccc cttttttttc aggtggttat ggacaaagta     2220

ttagtacaca gggggttttc aacccttaat gttattactg tcgcattatc tgttgtggtg     2280

gtgtttgaga ttatactcag cggtttaaga acttacattt ttgcacatag tacaagtcgg     2340

attgatgttg agttgggtgc caaactcttc cggcatttac tggcgctacc gatctcttat     2400

tttgagagtc gtcgtgttgg tgatactgtt gccagggtaa gagaattaga ccagatccgt     2460

aattttctga caggacaggc attaacatct gttctggact tattattttc attcatattt     2520

tttgcggtaa tgtggtatta cagcccaaag cttactctgg tgatcttatt ttcgctgccc     2580

tgttatgctg catggtctgt ttttattagc cccattttgc gacgtcgcct tgatgataag     2640

ttttcacgga atgcggataa tcaatctttc ctggtggaat cagtcacggc gattaacact     2700

ataaaagcta tggcagtctc acctcagatg acgaacatat gggacaaaca attggcagga     2760

tatgttgctg caggctttaa agtgacagta ttagccacca ttggtcaaca aggaatacag     2820

ttaatacaaa agactgttat gatcatcaac ctgtggttgg gagcacacct ggttatttcc     2880

ggggatttaa gtattggtca gttaattgct tttaatatgc ttgctggtca gattgttgca     2940

ccggttattc gccttgcaca aatctggcag gatttccagc aggttggtat atcagttacc     3000

cgccttggtg atgtgcttaa ctctccaact gaaagttatc atgggaaact ggcattaccg     3060

gaaattaatg gtaatatcac ttttcgtaat atccggtttc gctataagcc tgactctccg     3120

gttattttag ataatatcaa tctcagtatt aagcaggggg aggttattgg tattgtcgga     3180

cgttctggtt caggaaaaag cacattaact aaattaattc aacgttttta tattcctgaa     3240

aatggccagg tcttaattga tggacatgat cttgcgttgg ccgatcctaa ctggttacgt     3300

cgtcaggtgg gggttgtgtt gcaggacaat gtgctgctta atcgcagtat tattgataat     3360

atctcactgg ctaatcctgg tatgtccgtc gaaaaagtta tttatgcagc gaaattagca     3420

ggcgctcatg attttatttc tgaattgcgt gaggggtata acaccattgt cggggaacag     3480

ggggcaggat tatccggagg tcaacgtcaa cgcatcgcaa ttgcaagggc gctggtgaac     3540

aaccctaaaa tacttatttt tgatgaagca accagtgctc tggattatga gtcggagcat     3600

atcatcatgc gcaatatgca caaaatatgt aagggcagaa cggttataat cattgctcat     3660

cgtctgtcta cagtaaaaaa tgcagaccgc attattgtca tggaaaaagg gaaaattgtt     3720

gaacagggta aacataagga actgctttct gaaccggaaa gtttatacag ttacttatat     3780

cagttacagt cagactaaca gaaagaacag aagaatatga aaacatggtt aatggggttc     3840

agcgagttcc tgttgcgcta taaacttgtc tggagtgaaa catggaaaat ccggaagcaa     3900

ttagatactc cggtacgtga aaaggacgaa aatgaattct tacccgctca tctggaatta     3960

attgaaacgc cggtatccag acggccgcgt ctggttgctt attttattat ggggtttctg     4020

gttattgctg tcattttatc tgttttaggt caggtggaaa ttgttgccac tgcaaatggg     4080

aaattaacac taagtgggcg cagcaaagaa attaaaccta ttgaaaactc aatagttaaa     4140

gaaattatcg taaaagaagg agagtcagtc cggaaagggg atgtgttatt aaagcttaca     4200

gcactgggag ctgaagctga tacgttaaaa acacagtcat cactgttaca gaccaggctg     4260

gaacaaactc ggtatcaaat tctgagcagg tcaattgaat taaataaact acctgaactg     4320

aagcttcctg atgagcctta ttttcagaat gtatctgaag aggaagtact gcgtttaact     4380

tctttgataa aagaacagtt ttccacatgg caaaatcaga agtatcaaaa agaactgaat     4440

ctggataaga aaagagcaga gcgattaaca atacttgccc gtataaaccg ttatgaaaat     4500

ttatcgagag ttgaaaaaag ccgtctggat gatttcagga gtttattgca taaacaggca     4560

attgcaaaac atgctgtact tgagcaggag aataaatatg tcgaggcagc aaatgaatta     4620

cgggtttata aatcgcaact ggagcaaatt gagagtgaga tattgtctgc aaaagaagaa     4680

tatcagcttg tcacgcagct ttttaaaaat gaaattttag acaagctaag acaaacaaca     4740

gacaacattg agttattaac tctggagtta gagaaaaatg aagagcgtca acaggcttca     4800

gtaatcaggg cccctgtttc gggaaaagtt cagcaactga aggttcatac tgaaggtggg     4860

gttgttacaa cagcggaaac actgatggtc atcgttccgg aagatgacac gctggaggtt     4920

actgctctgg tacaaaataa agatattggt tttattaacg tcgggcagaa tgccatcatt     4980

aaagtggagg cctttcctta cacccgatat ggttatctgg tgggtaaggt gaaaaatata     5040

aatttagatg caatagaaga ccagaaactg ggactcgttt ttaatgtcat tgtttctgtt     5100

gaagagaatg atttgtcaac cgggaataag cacattccat taagctcggg tatggctgtc     5160

actgcagaaa taaagactgg aatgcgaagc gtaatcagct atcttcttag tcctctggaa     5220

gagtctgtaa cagaaagttt acatgagcgt taagtctcag agccgcggta tccggctcat     5280

atcttctcct g                                                          5291


<210> 797
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PDL-1 scFv

<400> 797
Met Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
            20                  25                  30          


Ser Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
225                 230                 235                 240 


Lys Arg Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 798
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PDL-1 scFv

<400> 798
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aagataggga      720

ccaggtaagg aggatgaatg gaagtgcagc tggtggagtc aggtggaggc ttggtgcaac      780

cgggcggttc actgcgtctg tcatgtgcgg cgtctgggtt tacttttagt gactcttgga      840

ttcactgggt gcgccaggct ccgggtaaag gcctggaatg ggtagcttgg attagtcctt      900

acggtggctc gacctattat gctgattcgg taaagggtcg ctttactatt agcgctgata      960

cttctaaaaa tactgcatac ctgcagatga atagcctgcg cgctgaggat actgctgtgt     1020

attattgcgc gcgtcgccac tggccgggcg gctttgatta ttggggccaa ggtactctgg     1080

ttaccgtgtc tagtggcggt ggtagcggcg gcggctcagg tggcggctcg ggcggtggcg     1140

acattcagat gactcagtct ccgtcttctt tgtcggcgag cgtgggcgat cgtgttacca     1200

tcacgtgtcg cgcgagccaa gatgtgtcga ctgcggtggc ttggtatcaa caaaaaccgg     1260

gtaaagctcc gaaactgctg atttatagtg cgtctttttt gtattctggt gttccgtctc     1320

gtttctctgg ctcaggtagc ggtactgatt ttacgctgac tatttcttca ctgcaaccgg     1380

aagattttgc tacgtattat tgtcaacaat atctgtatca cccggcgacg tttggtcagg     1440

gtactaaggt ggagataaaa cgccttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 799
<211> 294
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> anti PDL-1 scFv

<400> 799
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser Trp Ile His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Trp Ile Ser 
                165                 170                 175     


Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg His 
    210                 215                 220                 


Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                245                 250                 255     


Ala Gly Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu 
            260                 265                 270         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        275                 280                 285             


Thr Leu Thr Ala Ser Ala 
    290                 


<210> 800
<211> 5309
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> anti PDL-1 scFv

<400> 800
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaaaagtg aaataaatcc      720

cttcatgagg aggtaagatg gatattcaaa tgactcaatc tccgagctct ctgagtgcgt      780

ctgtgggtga tcgtgtgact attacttgtc gtgcgtctca agatgtttca actgcggttg      840

cgtggtatca acagaaaccg ggcaaggcgc ctaagctgct gatttattct gcttcgttcc      900

tgtacagcgg tgtgccgtct cgtttctctg gctctggttc gggtactgat ttcactctga      960

ctatttcgag tctgcagccg gaagattttg cgacttatta ttgtcaacaa tatctgtatc     1020

accctgcgac gtttggtcaa ggcacgaaag ttgaaattaa acgtggtggt ggctctggtg     1080

gtggcagcgg tggtgggtcg ggtggcggtg aagttcaact ggttgagtca ggtggtggcc     1140

tggtgcaacc gggcggctct ctgcgcctgt cttgtgctgc gtcgggtttt acgttctctg     1200

atagctggat tcactgggta cgccaggcac cgggcaaagg tctggaatgg gtagcttgga     1260

tttcacctta tggtggctct acttattacg cggatagcgt gaaaggtcgc tttactattt     1320

ctgcggacac tagcaaaaat actgcttacc tgcaaatgaa ttcgctgcgt gctgaggata     1380

ctgcagtgta ttactgtgcg cgtcgtcatt ggcctggcgg ctttgattat tggggtcaag     1440

gtactctggt tactgttagc agccttaatc cattaattaa tgaaatcagc aaaatcattt     1500

cagctgcagg taattttgat gttaaagagg aaagagctgc agcttcttta ttgcagttgt     1560

ccggtaatgc cagtgatttt tcatatggac ggaactcaat aactttgaca gcatcagcat     1620

aatttattaa tttaaataat agcaatctta ctgggctgtg ccacataaga ttgctatttt     1680

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1740

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgacaca     1800

gacgggactg gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1860

gtaaaacagg taaaaaaaac aattgaccga ttaaacttta tttctttgcc cgcattagtc     1920

tggagagagg atggacgtca ttttattctg actaaagtca gtaaagaagc aaacagatat     1980

cttatttttg atctggagca acgaaatccc cgtgttctcg aacagtctga gtttgaggcg     2040

ttatatcagg ggcatattat tcttattgct tcccgttctt ctgttaccgg gaaactggca     2100

aaatttgact ttacctggtt tatccctgcc attataaaat acagaaaaat atttattgaa     2160

acccttgttg tatctgtttt tttacaatta tttgcattaa taacccccct tttttttcag     2220

gtggttatgg acaaagtatt agtacacagg gggttttcaa cccttaatgt tattactgtc     2280

gcattatctg ttgtggtggt gtttgagatt atactcagcg gtttaagaac ttacattttt     2340

gcacatagta caagtcggat tgatgttgag ttgggtgcca aactcttccg gcatttactg     2400

gcgctaccga tctcttattt tgagagtcgt cgtgttggtg atactgttgc cagggtaaga     2460

gaattagacc agatccgtaa ttttctgaca ggacaggcat taacatctgt tctggactta     2520

ttattttcat tcatattttt tgcggtaatg tggtattaca gcccaaagct tactctggtg     2580

atcttatttt cgctgccctg ttatgctgca tggtctgttt ttattagccc cattttgcga     2640

cgtcgccttg atgataagtt ttcacggaat gcggataatc aatctttcct ggtggaatca     2700

gtcacggcga ttaacactat aaaagctatg gcagtctcac ctcagatgac gaacatatgg     2760

gacaaacaat tggcaggata tgttgctgca ggctttaaag tgacagtatt agccaccatt     2820

ggtcaacaag gaatacagtt aatacaaaag actgttatga tcatcaacct gtggttggga     2880

gcacacctgg ttatttccgg ggatttaagt attggtcagt taattgcttt taatatgctt     2940

gctggtcaga ttgttgcacc ggttattcgc cttgcacaaa tctggcagga tttccagcag     3000

gttggtatat cagttacccg ccttggtgat gtgcttaact ctccaactga aagttatcat     3060

gggaaactgg cattaccgga aattaatggt aatatcactt ttcgtaatat ccggtttcgc     3120

tataagcctg actctccggt tattttagat aatatcaatc tcagtattaa gcagggggag     3180

gttattggta ttgtcggacg ttctggttca ggaaaaagca cattaactaa attaattcaa     3240

cgtttttata ttcctgaaaa tggccaggtc ttaattgatg gacatgatct tgcgttggcc     3300

gatcctaact ggttacgtcg tcaggtgggg gttgtgttgc aggacaatgt gctgcttaat     3360

cgcagtatta ttgataatat ctcactggct aatcctggta tgtccgtcga aaaagttatt     3420

tatgcagcga aattagcagg cgctcatgat tttatttctg aattgcgtga ggggtataac     3480

accattgtcg gggaacaggg ggcaggatta tccggaggtc aacgtcaacg catcgcaatt     3540

gcaagggcgc tggtgaacaa ccctaaaata cttatttttg atgaagcaac cagtgctctg     3600

gattatgagt cggagcatat catcatgcgc aatatgcaca aaatatgtaa gggcagaacg     3660

gttataatca ttgctcatcg tctgtctaca gtaaaaaatg cagaccgcat tattgtcatg     3720

gaaaaaggga aaattgttga acagggtaaa cataaggaac tgctttctga accggaaagt     3780

ttatacagtt acttatatca gttacagtca gactaacaga aagaacagaa gaatatgaaa     3840

acatggttaa tggggttcag cgagttcctg ttgcgctata aacttgtctg gagtgaaaca     3900

tggaaaatcc ggaagcaatt agatactccg gtacgtgaaa aggacgaaaa tgaattctta     3960

cccgctcatc tggaattaat tgaaacgccg gtatccagac ggccgcgtct ggttgcttat     4020

tttattatgg ggtttctggt tattgctgtc attttatctg ttttaggtca ggtggaaatt     4080

gttgccactg caaatgggaa attaacacta agtgggcgca gcaaagaaat taaacctatt     4140

gaaaactcaa tagttaaaga aattatcgta aaagaaggag agtcagtccg gaaaggggat     4200

gtgttattaa agcttacagc actgggagct gaagctgata cgttaaaaac acagtcatca     4260

ctgttacaga ccaggctgga acaaactcgg tatcaaattc tgagcaggtc aattgaatta     4320

aataaactac ctgaactgaa gcttcctgat gagccttatt ttcagaatgt atctgaagag     4380

gaagtactgc gtttaacttc tttgataaaa gaacagtttt ccacatggca aaatcagaag     4440

tatcaaaaag aactgaatct ggataagaaa agagcagagc gattaacaat acttgcccgt     4500

ataaaccgtt atgaaaattt atcgagagtt gaaaaaagcc gtctggatga tttcaggagt     4560

ttattgcata aacaggcaat tgcaaaacat gctgtacttg agcaggagaa taaatatgtc     4620

gaggcagcaa atgaattacg ggtttataaa tcgcaactgg agcaaattga gagtgagata     4680

ttgtctgcaa aagaagaata tcagcttgtc acgcagcttt ttaaaaatga aattttagac     4740

aagctaagac aaacaacaga caacattgag ttattaactc tggagttaga gaaaaatgaa     4800

gagcgtcaac aggcttcagt aatcagggcc cctgtttcgg gaaaagttca gcaactgaag     4860

gttcatactg aaggtggggt tgttacaaca gcggaaacac tgatggtcat cgttccggaa     4920

gatgacacgc tggaggttac tgctctggta caaaataaag atattggttt tattaacgtc     4980

gggcagaatg ccatcattaa agtggaggcc tttccttaca cccgatatgg ttatctggtg     5040

ggtaaggtga aaaatataaa tttagatgca atagaagacc agaaactggg actcgttttt     5100

aatgtcattg tttctgttga agagaatgat ttgtcaaccg ggaataagca cattccatta     5160

agctcgggta tggctgtcac tgcagaaata aagactggaa tgcgaagcgt aatcagctat     5220

cttcttagtc ctctggaaga gtctgtaaca gaaagtttac atgagcgtta agtctcagag     5280

ccgcggtatc cggctcatat cttctcctg                                       5309


<210> 801
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fliC promoter

<400> 801
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggt                       104


<210> 802
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> fliC 5 untranslated region

<400> 802
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaac                       45


<210> 803
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Tetracycline responsive promoter

<400> 803
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaa                                 96


<210> 804
<211> 705
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Tetracycline responsive promoter

<400> 804
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcatttata gagttaattt accactccct atcagtgata gagaa                      705


<210> 805
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 805
aaataaaaat gaggaggcaa ttcta                                             25


<210> 806
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 806
agattataag gagttaaata gaaaa                                             25


<210> 807
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 807
ctcaaagaat tataggaaag gaggaagcga taagt                                  35


<210> 808
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 808
atcaccaatt tgaggaaagg taaat                                             25


<210> 809
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 809
tggcagacgc ctaaggagga agacc                                             25


<210> 810
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 810
tacataattt tggggagggt actcg                                             25


<210> 811
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 811
ttaaatatca actagaggtc accaa                                             25


<210> 812
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 812
tacgatttaa ttcggaggtt ttttg                                             25


<210> 813
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 813
tcacaacgct gagagagaga gaaat                                             25


<210> 814
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 814
gttaaattga ggaggaggca gttcc                                             25


<210> 815
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 815
tataccgaac gcttaaggag gcttt                                             25


<210> 816
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 816
ataaatccct tcatgaggag gtaag                                             25


<210> 817
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized ribosome binding site

<400> 817
gatagggacc aggtaaggag gatga                                             25


<210> 818
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Terminator sequence

<400> 818
tcgccgtaac ctgattaact gagactgacg gcaacgccaa attgcctgat gcgctgcgct       60

tatcaggcct acaaggggaa ttgcaattta ttgaatttgc acatttttgt aggccggata      120

aggcgtttac gccgcatccg gcaacatgaa tggtaatttg ccagcaacgt gcttccccgc      180

caacggcggg gttttttctg                                                  200


<210> 819
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Terminator sequence

<400> 819
ctctaacgga cttgagtgag gttgtaaagg gagttggctc ctcggtacca aattccagaa       60

aagaggcctc ccgaaagggg ggcctttttt cgtttt                                 96


<210> 820
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Terminator sequence

<400> 820
gtctcagagc cgcggtatcc ggctcatatc ttctcctg                               38


<210> 821
<211> 177
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> N terminal secretion tag for Type V auto-secreter
      secretion

<400> 821
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgc         177


<210> 822
<211> 921
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> C terminal secretion tag for Type V auto-secreter
      secretion

<400> 822
ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt       60

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac      120

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc      180

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac      240

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac      300

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag      360

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg      420

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa      480

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt      540

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg      600

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc      660

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta      720

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa      780

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt      840

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg      900

aatttccgct acatgtttta a                                                921


<210> 823
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-CTLA-4 single chain antibody coding region (Heavy
      Chain linker Light Chain)

<400> 823
atgcaagtgc aactggtaga gtccggtggg ggcgtggtgc agccgggtcg cagcctgcgt       60

ctgtcgtgcg cggcgagtgg ttttacgttt tcgagttata ctatgcactg ggttcgtcaa      120

gcgccgggca aaggcctgga atgggttact ttcatttctt acgatggtaa taataaatat      180

tatgcggatt ctgtgaaagg tcgctttact atttcgcgcg ataacagtaa aaacactctg      240

tatctgcaaa tgaattctct gcgtgcagag gatactgcta tctattactg cgcgcgtacg      300

ggctggttgg gcccgtttga ttattggggc caaggcactt tggttactgt gtcatcgggc      360

gggggctctg gcggtggttc aggtggtggc agtggtggtg gcgagatcgt gttgactcaa      420

tctccgggta ctctgtctct gtctccgggt gaacgcgcga ccctgtcttg ccgcgcttct      480

cagagtgttg gttcatcgta tctggcatgg tatcaacaga aaccgggtca agcgccgcgt      540

ctgctgattt acggtgcttt tagtcgcgca accgggattc cggatcgatt ttctggttca      600

ggttctggca ctgactttac tttgactatt agtcgtctgg aaccggagga cttcgcggtt      660

tattattgcc aacagtatgg ttcttctccg tggacctttg gtcaaggcac taaagttgaa      720

attaaataa                                                              729


<210> 824
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-CTLA-4 single chain antibody coding region (Light
      Chain linker Heavy Chain)

<400> 824
atggagattg tactgaccca gagccctggt acattgtctt tgtcgcctgg tgaacgcgcg       60

actctgtctt gtcgtgcgtc tcagtctgtt ggtagttcgt atctggcgtg gtatcaacaa      120

aaaccgggcc aagctccgcg tctgctgatt tacggtgcat ttagccgcgc gactggcatt      180

ccggaccgct tttctgggtc tggctcaggt accgatttta ctctgactat ttcgcgtctg      240

gagccggagg atttcgcggt ttattactgc cagcaatatg gttctagtcc gtggaccttc      300

ggccaaggta ctaaagtgga aatcaaaggc gggggttcgg gtggtggctc tgggggtggc      360

tcgggcggtg ggcaggtgca actggttgag agtggtggcg gcgttgttca accgggccgc      420

tctctgcgcc tgtcgtgcgc tgcttctggc tttaccttta gctcttatac gatgcactgg      480

gttcgccaag ctccgggtaa aggtctggag tgggtgactt tcatttctta cgatggtaac      540

aacaaatatt atgctgattc tgttaaaggc cgttttacta tttctcgaga caatagcaaa      600

aacactctgt acctgcagat gaattctctg cgcgctgaag acaccgcgat ttattattgt      660

gcgcgcactg gttggctggg tccgtttgat tattggggtc agggcacgct ggttactgtt      720

agctcgtga                                                              729


<210> 825
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-1 single chain antibody coding region (Heavy
      Chain linker Light Chain)

<400> 825
atgcaggtgc aattggtgga gtcgggtggc ggcgtggtgc aaccgggtcg tagcctgcgc       60

ctggattgta aagcgtcagg catcacgttt agcaattctg gcatgcactg ggtgcgtcaa      120

gcgccgggca aaggtctgga gtgggttgcg gtaatttggt acgatggttc taaacgctat      180

tacgcggata gtgtgaaagg tcgctttact atctctcgcg ataattctaa aaacaccctg      240

tttctgcaaa tgaattcgtt gcgtgcggaa gatactgcgg tatattattg tgctactaac      300

gatgattatt ggggtcaagg caccctggtg actgtttcga gcggcggtgg tagcggcggc      360

ggctctggtg gtggttctgg tggcggtgag attgtgctga ctcaaagccc ggcgaccctg      420

tctctgtcgc cgggtgaacg cgctactctg agttgccgtg cgtcgcaaag cgtgtcttct      480

tatctggcgt ggtaccaaca aaaaccgggt caagcgccgc gcctgctgat atatgatgct      540

agtaatcgtg caacgggtat tccggcacgc ttttcaggtt ctggcagcgg caccgatttc      600

actctgacta tctcgtcact ggagccggaa gactttgcgg tttattattg tcagcaatct      660

tctaattggc cgcgtacgtt tggtcagggc actaaagttg aaatcaaata a               711


<210> 826
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-1 single chain antibody coding region (Light
      Chain linker Heavy Chain)

<400> 826
atggaaatcg ttttaacgca gtcgccggcg actctgtctt tgtcgcctgg tgaacgtgct       60

acgctgtctt gccgcgcgtc acagtctgtg tcgtcatatc tggcttggta ccaacagaaa      120

ccgggccaag ctccgcgcct gctgatttat gatgcgtcta atcgcgcgac cggcattccg      180

gcgcgttttt ctggctccgg ctctggcacc gactttactc tgactatttc gtctctggaa      240

ccggaagatt ttgcggtgta ctattgccag caatcttcta attggccgcg cacgtttggt      300

caaggtacca aggttgagat caaaggtggt ggctcgggcg gcggttcggg cggcggctca      360

ggtggtggcc aagttcagtt ggttgagtct ggcgggggcg tagtacaacc gggtcgttct      420

ttgcgtctgg attgcaaagc gagcggtatt acctttagca attcaggtat gcactgggtg      480

cgccaagcgc cgggcaaagg cctggaatgg gttgcggtga tttggtacga tggctcgaaa      540

cgttattatg ctgacagcgt taaaggtcgt tttactatta gccgtgataa ttccaaaaat      600

acgctgtttc tgcagatgaa tagcctgcgt gctgaagaca ctgcggttta ttactgtgct      660

actaatgatg attactgggg ccagggcacc ctggtgactg tgagttctta a               711


<210> 827
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-L1 single chain antibody coding region (Light
      Chain linker Heavy Chain)

<400> 827
atggatattc agatgactca gagccctagc tcactgtctg cgtcagttgg cgatcgtgtg       60

actattacct gtcgcgctag tcaggatgtg tctacggcgg ttgcgtggta tcaacagaaa      120

ccgggcaaag ctccgaaact gttgatttat tcagcgtctt tcctgtattc gggtgtgcct      180

tctcgctttt cgggctctgg tagcggtact gattttacgc tgactattag ttcactgcaa      240

ccggaggact ttgcgactta ttattgccaa caatacctgt atcacccggc gacctttggt      300

caaggcacta aagtggaaat taaacgcggc ggcggcagcg gtggcggctc tggtggtggg      360

tctggtggtg gtgaggttca gctggttgag tctggtggtg gtctggttca acctgggggc      420

agcctgcgcc tgtcgtgcgc ggcgtctggt tttacgttct cagattcttg gattcactgg      480

gtacgtcaag ctccgggcaa aggtctggag tgggtggcgt ggatttctcc gtatggcggt      540

tcgacgtatt acgcggactc tgttaaaggg cgttttacga tctcagcgga tacttctaaa      600

aatactgcgt atctgcaaat gaattctctg cgagcggagg ataccgcggt gtattactgt      660

gctcgccgcc actggcctgg tggtttcgat tattggggtc aaggtaccct ggtgactgtt      720

tcgtcttaa                                                              729


<210> 828
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-L1 single chain antibody coding region (Heavy
      Chain linker Light Chain)

<400> 828
atggaagttc agctggtgga gagtggtggc ggtctggtgc agccgggcgg ctctctgcgt       60

ctgagctgtg cggcgtctgg ctttacgttt tctgacagtt ggattcactg ggtgcgccaa      120

gcaccgggca aaggcctgga gtgggtggcg tggatttctc cgtatggcgg tagtacttat      180

tatgctgatt ctgtgaaagg ccgttttacc atttcggcgg acacttcaaa aaataccgcg      240

tatctgcaaa tgaatagcct gcgcgctgaa gacacggctg tttactactg tgctcgccgc      300

cactggccgg gcggtttcga ttattggggc caaggcactc tggtgactgt gagctctggc      360

ggcgggtcgg gtggcggttc tggcggtggc agtggcggtg gtgatattca aatgacccaa      420

tctccgtcgt ctctgagcgc gtctgtgggc gatcgtgtaa ccattacttg tcgtgcgtcg      480

caggatgtgt ctactgctgt ggcgtggtat cagcaaaaac cgggtaaagc tccgaaactg      540

ctgatttata gcgcttcttt tctgtatagt ggtgttccgt cacgttttag cggttcaggc      600

tctggtactg atttcacact gactatttct tctctgcaac cggaagattt cgcgacttat      660

tattgtcagc agtacttgta ccacccggca acttttggtc agggcactaa agttgaaatt      720

aaacgttaa                                                              729


<210> 829
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-CTLA-4 single chain antibody coding region (Heavy
      Chain linker Light Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter

<400> 829
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgccag      180

gtacaattag ttgagagcgg cggcggtgtg gttcaaccgg gccgtagtct gcgattgtct      240

tgtgctgcat ctggttttac tttcagttct tacacgatgc actgggttcg ccaagctccg      300

ggcaaaggcc tggagtgggt tacctttatt tcttacgatg gcaataataa gtattacgct      360

gattctgtga aaggtcgctt tactattagc cgagataact ctaaaaatac tctgtatctg      420

caaatgaatt ctctgcgtgc ggaagatact gcgatctatt attgtgcgcg tactggttgg      480

ctgggcccgt ttgattattg gggccaaggc acgctggtta ctgttagttc gggcggcggt      540

tctggtggcg gctctggtgg tggctctggc ggcggcgaga ttgtgctgac tcaatctccg      600

ggcacgctgt cactgtctcc gggtgaacgc gcgaccctgt cttgtcgcgc gagtcaaagt      660

gttggttctt cttatctggc ttggtatcag caaaagcctg gtcaagcgcc gcgtctgttg      720

atttatggcg cgttttcgcg cgcgactggc attccggacc gattttctgg ttctggttct      780

ggcactgatt tcactctgac catttcacgc ctggaaccgg aggattttgc ggtgtactat      840

tgccaacaat atggctcatc gccgtggacg tttggccaag gtactaaagt tgagattaaa      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 830
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-CTLA-4 single chain antibody coding region (Light
      Chain linker Heavy Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter

<400> 830
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgaa      180

attgtactga cccagtcgcc tggtaccctg tctctgtcgc cgggtgaacg tgctaccctg      240

tcttgtcgtg cttcgcaatc ggttggctcg tcttatctgg catggtatca gcaaaaaccg      300

ggccaagcgc ctcgtctgct gatttatggc gcgttttctc gtgctacggg cattcctgat      360

cgtttttcgg gctctggctc tggtactgat tttacgctga ctatcagccg cttggaacct      420

gaagattttg cggtttatta ttgccaacaa tatggctctt ctccgtggac gtttggtcaa      480

ggcactaaag ttgaaattaa aggtggtggc tcgggcggtg gttctggtgg tggtagtggt      540

ggtggtcaag tgcagttggt tgaatcgggt ggcggtgttg tgcagccggg ccgttcgttg      600

cgtctgtctt gcgcagcgag tggtttcacc ttctcttctt atactatgca ctgggtgcgt      660

caagcacctg gcaaaggtct ggagtgggta acttttattt catacgatgg taataataaa      720

tattatgcag attctgttaa aggtcgcttt acgatttctc gcgataattc aaaaaatacg      780

ctgtatctgc agatgaattc gctgcgcgct gaggatactg cgatctacta ttgtgcgcgt      840

actggttggc tgggtccgtt tgattactgg ggccaaggta cgctggttac agtttcgtcg      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 831
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-1 single chain antibody coding region (Heavy
      Chain linker  Light Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter

<400> 831
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgccaa      180

gtacaactgg ttgaatccgg cggaggagtg gtgcaaccgg gccgcagttt gcgtctggat      240

tgtaaagctt caggcatcac tttttctaat tctggtatgc actgggttcg ccaagctccg      300

ggtaaaggtc tggagtgggt tgcggtgatc tggtatgatg gttctaaacg atattatgcg      360

gatagtgtta agggtcgttt tactatttct cgtgataatt ctaagaacac cttgtttctg      420

cagatgaata gtctgcgcgc tgaggatact gcggtatatt attgtgcgac taatgacgat      480

tattggggcc aaggcacgct ggttaccgtg agctctggtg gtggttcggg tggtggttct      540

ggtggtggga gcggcggtgg cgagatcgtt ctgactcaaa gcccggcgac tctgagtctg      600

agtccgggtg aacgtgcgac tctgagctgc cgtgcgtctc agagtgtgtc gagttatctg      660

gcgtggtacc aacaaaaacc gggccaggcg ccgcgactgc tgatttatga tgcttctaat      720

cgtgcgactg gtattccggc gcgctttagc ggttctggct caggcactga cttcactctg      780

actatttctt cgctggaacc ggaagatttt gcggtgtact attgtcaaca atcatctaat      840

tggcctcgta cgttcggtca aggtacaaaa gtggagataa aattcaaagc ggaggctgac      900

aaggccgctg cagcaaaagc tgactccttt atgaacgcgg gttacaaaaa cttcatgacc      960

gaggtaaata atctcaataa acgtatgggt gatctgcgcg acactaatgg ggatgcaggc     1020

gcatgggcac gcattatgtc tggtgcaggt tcggcggatg gcgggtattc tgacaattac     1080

actcatgttc aggtgggctt cgataaaaaa catgagctgg acggtgtgga tctgttcact     1140

ggcgtaacca tgacttatac tgattcaagc gcagacagcc acgcattttc aggtaaaacg     1200

aaatcagttg gcggcggtct gtatgcgagc gcactgttcg agagcggcgc ctacattgat     1260

ctaattggca agtatattca ccatgataat gattacacag ggaactttgc aggcctgggc     1320

accaaacact ataacacgca ttcatggtac gctggcgcag aaaccggcta tagataccac     1380

ctgaccgagg aaacctttat cgaaccgcaa gcggaactgg tttacggtgc ggtcagtggc     1440

aagacctttc gttggaaaga tggtgatatg gatctgtcaa tgaaaaaccg cgacttcagc     1500

cccttgatcg gccgcaccgg cattgagctg ggcaaaacct tctctggcaa agattggtct     1560

gttaccgcgc gtgcgggcac ttcgtggcaa tttgatctgc taaacaacgg tgagactgta     1620

ctgcgtgatg cgagtggcga aaaacgtatt aaaggtgaaa aagatagtag aatgctattc     1680

aacgtgggca tgaatgcgca gatcaaagat aacatgcgtt ttgggttgga gtttgaaaaa     1740

tccgcgttcg gtaaatataa tgttgacaat gctgtgaacg cgaatttccg ctacatgttt     1800

taa                                                                   1803


<210> 832
<211> 1803
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-1 single chain antibody coding region (Light
      Chain linker Heavy Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter

<400> 832
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgaa      180

atcgtgctga ctcagagtcc ggcgactctg tctctgagtc cgggcgaacg cgcgactctg      240

tcttgccgtg cgtctcaatc tgtgtcttca tacttggctt ggtaccaaca aaaaccgggc      300

caggcgccgc gactgttgat ttatgatgcg tcgaatcgcg cgactggcat tccggcgcgc      360

ttttcgggta gcggttctgg tactgatttt acgctgacta tctcttctct ggagcctgaa      420

gatttcgctg tttattactg ccaacagtct agtaattggc cgcgtacttt cggccagggc      480

actaaggtgg aaattaaagg tggcggctcg ggcggcggct cgggtggtgg ttctggtggt      540

ggccaagtgc aactggtgga aagtggcggc ggggtggtgc aaccgggccg ttctctgcgc      600

ctggattgta aagcttcagg cattactttt agcaactctg gtatgcactg ggttcgccaa      660

gctccgggca aaggcctgga atgggtggcg gttatttggt acgatggctc taaacgttat      720

tacgctgaca gtgttaaagg ccgctttacc atttctcgtg ataattctaa aaataccctg      780

tttctgcaaa tgaactcgct gcgcgcggaa gatactgctg tttactattg tgcgactaat      840

gatgattact ggggtcaagg taccctggtt accgtgtctt ctttcaaagc ggaggctgac      900

aaggccgctg cagcaaaagc tgactccttt atgaacgcgg gttacaaaaa cttcatgacc      960

gaggtaaata atctcaataa acgtatgggt gatctgcgcg acactaatgg ggatgcaggc     1020

gcatgggcac gcattatgtc tggtgcaggt tcggcggatg gcgggtattc tgacaattac     1080

actcatgttc aggtgggctt cgataaaaaa catgagctgg acggtgtgga tctgttcact     1140

ggcgtaacca tgacttatac tgattcaagc gcagacagcc acgcattttc aggtaaaacg     1200

aaatcagttg gcggcggtct gtatgcgagc gcactgttcg agagcggcgc ctacattgat     1260

ctaattggca agtatattca ccatgataat gattacacag ggaactttgc aggcctgggc     1320

accaaacact ataacacgca ttcatggtac gctggcgcag aaaccggcta tagataccac     1380

ctgaccgagg aaacctttat cgaaccgcaa gcggaactgg tttacggtgc ggtcagtggc     1440

aagacctttc gttggaaaga tggtgatatg gatctgtcaa tgaaaaaccg cgacttcagc     1500

cccttgatcg gccgcaccgg cattgagctg ggcaaaacct tctctggcaa agattggtct     1560

gttaccgcgc gtgcgggcac ttcgtggcaa tttgatctgc taaacaacgg tgagactgta     1620

ctgcgtgatg cgagtggcga aaaacgtatt aaaggtgaaa aagatagtag aatgctattc     1680

aacgtgggca tgaatgcgca gatcaaagat aacatgcgtt ttgggttgga gtttgaaaaa     1740

tccgcgttcg gtaaatataa tgttgacaat gctgtgaacg cgaatttccg ctacatgttt     1800

taa                                                                   1803


<210> 833
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-L1 single chain antibody coding region (Light
      Chain linker Heavy Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter

<400> 833
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgat      180

attcaaatga ctcaatctcc gagctctctg agtgcgtctg tgggtgatcg tgtgactatt      240

acttgtcgtg cgtctcaaga tgtttcaact gcggttgcgt ggtatcaaca gaaaccgggc      300

aaggcgccta agctgctgat ttattctgct tcgttcctgt acagcggtgt gccgtctcgt      360

ttctctggct ctggttcggg tactgatttc actctgacta tttcgagtct gcagccggaa      420

gattttgcga cttattattg tcaacaatat ctgtatcacc ctgcgacgtt tggtcaaggc      480

acgaaagttg aaattaaacg tggtggtggc tctggtggtg gcagcggtgg tgggtcgggt      540

ggcggtgaag ttcaactggt tgagtcaggt ggtggcctgg tgcaaccggg cggctctctg      600

cgcctgtctt gtgctgcgtc gggttttacg ttctctgata gctggattca ctgggtacgc      660

caggcaccgg gcaaaggtct ggaatgggta gcttggattt caccttatgg tggctctact      720

tattacgcgg atagcgtgaa aggtcgcttt actatttctg cggacactag caaaaatact      780

gcttacctgc aaatgaattc gctgcgtgct gaggatactg cagtgtatta ctgtgcgcgt      840

cgtcattggc ctggcggctt tgattattgg ggtcaaggta ctctggttac tgttagcagc      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 834
<211> 1821
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-L1 single chain antibody coding region (Heavy
      Chain linker Light Chain) with N terminal and C terminal
      Secretion Tag for Type V auto-secreter

<400> 834
atgaacaaag tatatagcct gaaatattgc ccagtaactg ggggtctgat tgtagtcagt       60

gaactggcat cccgcgtcat caaaaaaacc tgccgtcgtc tgactcacat cctgctggcg      120

ggtattccgg ctgtgtatct gtactacccg cagatctccc aggcaggtat cgtccgcgaa      180

gtgcagctgg tggagtcagg tggaggcttg gtgcaaccgg gcggttcact gcgtctgtca      240

tgtgcggcgt ctgggtttac ttttagtgac tcttggattc actgggtgcg ccaggctccg      300

ggtaaaggcc tggaatgggt agcttggatt agtccttacg gtggctcgac ctattatgct      360

gattcggtaa agggtcgctt tactattagc gctgatactt ctaaaaatac tgcatacctg      420

cagatgaata gcctgcgcgc tgaggatact gctgtgtatt attgcgcgcg tcgccactgg      480

ccgggcggct ttgattattg gggccaaggt actctggtta ccgtgtctag tggcggtggt      540

agcggcggcg gctcaggtgg cggctcgggc ggtggcgaca ttcagatgac tcagtctccg      600

tcttctttgt cggcgagcgt gggcgatcgt gttaccatca cgtgtcgcgc gagccaagat      660

gtgtcgactg cggtggcttg gtatcaacaa aaaccgggta aagctccgaa actgctgatt      720

tatagtgcgt cttttttgta ttctggtgtt ccgtctcgtt tctctggctc aggtagcggt      780

actgatttta cgctgactat ttcttcactg caaccggaag attttgctac gtattattgt      840

caacaatatc tgtatcaccc ggcgacgttt ggtcagggta ctaaggtgga gataaaacgc      900

ttcaaagcgg aggctgacaa ggccgctgca gcaaaagctg actcctttat gaacgcgggt      960

tacaaaaact tcatgaccga ggtaaataat ctcaataaac gtatgggtga tctgcgcgac     1020

actaatgggg atgcaggcgc atgggcacgc attatgtctg gtgcaggttc ggcggatggc     1080

gggtattctg acaattacac tcatgttcag gtgggcttcg ataaaaaaca tgagctggac     1140

ggtgtggatc tgttcactgg cgtaaccatg acttatactg attcaagcgc agacagccac     1200

gcattttcag gtaaaacgaa atcagttggc ggcggtctgt atgcgagcgc actgttcgag     1260

agcggcgcct acattgatct aattggcaag tatattcacc atgataatga ttacacaggg     1320

aactttgcag gcctgggcac caaacactat aacacgcatt catggtacgc tggcgcagaa     1380

accggctata gataccacct gaccgaggaa acctttatcg aaccgcaagc ggaactggtt     1440

tacggtgcgg tcagtggcaa gacctttcgt tggaaagatg gtgatatgga tctgtcaatg     1500

aaaaaccgcg acttcagccc cttgatcggc cgcaccggca ttgagctggg caaaaccttc     1560

tctggcaaag attggtctgt taccgcgcgt gcgggcactt cgtggcaatt tgatctgcta     1620

aacaacggtg agactgtact gcgtgatgcg agtggcgaaa aacgtattaa aggtgaaaaa     1680

gatagtagaa tgctattcaa cgtgggcatg aatgcgcaga tcaaagataa catgcgtttt     1740

gggttggagt ttgaaaaatc cgcgttcggt aaatataatg ttgacaatgc tgtgaacgcg     1800

aatttccgct acatgtttta a                                               1821


<210> 835
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-CTLA-4 single chain antibody coding region (Heavy
      Chain linker Light Chain) for type I hemolysin secretion,
      including HlyA tag

<400> 835
atgcaggtac aattagttga gagcggcggc ggtgtggttc aaccgggccg tagtctgcga       60

ttgtcttgtg ctgcatctgg ttttactttc agttcttaca cgatgcactg ggttcgccaa      120

gctccgggca aaggcctgga gtgggttacc tttatttctt acgatggcaa taataagtat      180

tacgctgatt ctgtgaaagg tcgctttact attagccgag ataactctaa aaatactctg      240

tatctgcaaa tgaattctct gcgtgcggaa gatactgcga tctattattg tgcgcgtact      300

ggttggctgg gcccgtttga ttattggggc caaggcacgc tggttactgt tagttcgggc      360

ggcggttctg gtggcggctc tggtggtggc tctggcggcg gcgagattgt gctgactcaa      420

tctccgggca cgctgtcact gtctccgggt gaacgcgcga ccctgtcttg tcgcgcgagt      480

caaagtgttg gttcttctta tctggcttgg tatcagcaaa agcctggtca agcgccgcgt      540

ctgttgattt atggcgcgtt ttcgcgcgcg actggcattc cggaccgatt ttctggttct      600

ggttctggca ctgatttcac tctgaccatt tcacgcctgg aaccggagga ttttgcggtg      660

tactattgcc aacaatatgg ctcatcgccg tggacgtttg gccaaggtac taaagttgag      720

attaaactta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 836
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-CTLA-4 single chain antibody coding region (Light
      Chain linker Heavy Chain) for type I hemolysin secretion,
      including HlyA tag

<400> 836
atggaaattg tactgaccca gtcgcctggt accctgtctc tgtcgccggg tgaacgtgct       60

accctgtctt gtcgtgcttc gcaatcggtt ggctcgtctt atctggcatg gtatcagcaa      120

aaaccgggcc aagcgcctcg tctgctgatt tatggcgcgt tttctcgtgc tacgggcatt      180

cctgatcgtt tttcgggctc tggctctggt actgatttta cgctgactat cagccgcttg      240

gaacctgaag attttgcggt ttattattgc caacaatatg gctcttctcc gtggacgttt      300

ggtcaaggca ctaaagttga aattaaaggt ggtggctcgg gcggtggttc tggtggtggt      360

agtggtggtg gtcaagtgca gttggttgaa tcgggtggcg gtgttgtgca gccgggccgt      420

tcgttgcgtc tgtcttgcgc agcgagtggt ttcaccttct cttcttatac tatgcactgg      480

gtgcgtcaag cacctggcaa aggtctggag tgggtaactt ttatttcata cgatggtaat      540

aataaatatt atgcagattc tgttaaaggt cgctttacga tttctcgcga taattcaaaa      600

aatacgctgt atctgcagat gaattcgctg cgcgctgagg atactgcgat ctactattgt      660

gcgcgtactg gttggctggg tccgtttgat tactggggcc aaggtacgct ggttacagtt      720

tcgtcgctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 837
<211> 867
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-1 single chain antibody coding region (Heavy
      Chain linker Light Chain) for type I hemolysin secretion,
      including HlyA tag

<400> 837
atgcaagtac aactggttga atccggcgga ggagtggtgc aaccgggccg cagtttgcgt       60

ctggattgta aagcttcagg catcactttt tctaattctg gtatgcactg ggttcgccaa      120

gctccgggta aaggtctgga gtgggttgcg gtgatctggt atgatggttc taaacgatat      180

tatgcggata gtgttaaggg tcgttttact atttctcgtg ataattctaa gaacaccttg      240

tttctgcaga tgaatagtct gcgcgctgag gatactgcgg tatattattg tgcgactaat      300

gacgattatt ggggccaagg cacgctggtt accgtgagct ctggtggtgg ttcgggtggt      360

ggttctggtg gtgggagcgg cggtggcgag atcgttctga ctcaaagccc ggcgactctg      420

agtctgagtc cgggtgaacg tgcgactctg agctgccgtg cgtctcagag tgtgtcgagt      480

tatctggcgt ggtaccaaca aaaaccgggc caggcgccgc gactgctgat ttatgatgct      540

tctaatcgtg cgactggtat tccggcgcgc tttagcggtt ctggctcagg cactgacttc      600

actctgacta tttcttcgct ggaaccggaa gattttgcgg tgtactattg tcaacaatca      660

tctaattggc ctcgtacgtt cggtcaaggt acaaaagtgg agataaaact taatccatta      720

attaatgaaa tcagcaaaat catttcagct gcaggtaatt ttgatgttaa agaggaaaga      780

gctgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac      840

tcaataactt tgacagcatc agcataa                                          867


<210> 838
<211> 867
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-1 single chain antibody coding region (Light
      Chain linker Heavy Chain) for type I hemolysin secretion,
      including HlyA tag

<400> 838
atggaaatcg tgctgactca gagtccggcg actctgtctc tgagtccggg cgaacgcgcg       60

actctgtctt gccgtgcgtc tcaatctgtg tcttcatact tggcttggta ccaacaaaaa      120

ccgggccagg cgccgcgact gttgatttat gatgcgtcga atcgcgcgac tggcattccg      180

gcgcgctttt cgggtagcgg ttctggtact gattttacgc tgactatctc ttctctggag      240

cctgaagatt tcgctgttta ttactgccaa cagtctagta attggccgcg tactttcggc      300

cagggcacta aggtggaaat taaaggtggc ggctcgggcg gcggctcggg tggtggttct      360

ggtggtggcc aagtgcaact ggtggaaagt ggcggcgggg tggtgcaacc gggccgttct      420

ctgcgcctgg attgtaaagc ttcaggcatt acttttagca actctggtat gcactgggtt      480

cgccaagctc cgggcaaagg cctggaatgg gtggcggtta tttggtacga tggctctaaa      540

cgttattacg ctgacagtgt taaaggccgc tttaccattt ctcgtgataa ttctaaaaat      600

accctgtttc tgcaaatgaa ctcgctgcgc gcggaagata ctgctgttta ctattgtgcg      660

actaatgatg attactgggg tcaaggtacc ctggttaccg tgtcttctct taatccatta      720

attaatgaaa tcagcaaaat catttcagct gcaggtaatt ttgatgttaa agaggaaaga      780

gctgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac      840

tcaataactt tgacagcatc agcataa                                          867


<210> 839
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-L1 single chain antibody coding region (Light
      Chain linker Heavy Chain) for type I hemolysin secretion,
      including HlyA tag

<400> 839
atggatattc aaatgactca atctccgagc tctctgagtg cgtctgtggg tgatcgtgtg       60

actattactt gtcgtgcgtc tcaagatgtt tcaactgcgg ttgcgtggta tcaacagaaa      120

ccgggcaagg cgcctaagct gctgatttat tctgcttcgt tcctgtacag cggtgtgccg      180

tctcgtttct ctggctctgg ttcgggtact gatttcactc tgactatttc gagtctgcag      240

ccggaagatt ttgcgactta ttattgtcaa caatatctgt atcaccctgc gacgtttggt      300

caaggcacga aagttgaaat taaacgtggt ggtggctctg gtggtggcag cggtggtggg      360

tcgggtggcg gtgaagttca actggttgag tcaggtggtg gcctggtgca accgggcggc      420

tctctgcgcc tgtcttgtgc tgcgtcgggt tttacgttct ctgatagctg gattcactgg      480

gtacgccagg caccgggcaa aggtctggaa tgggtagctt ggatttcacc ttatggtggc      540

tctacttatt acgcggatag cgtgaaaggt cgctttacta tttctgcgga cactagcaaa      600

aatactgctt acctgcaaat gaattcgctg cgtgctgagg atactgcagt gtattactgt      660

gcgcgtcgtc attggcctgg cggctttgat tattggggtc aaggtactct ggttactgtt      720

agcagcctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 840
<211> 885
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Anti-PD-L1 single chain antibody coding region (Heavy
      Chain linker Light Chain) for type I hemolysin secretion,
      including HlyA tag

<400> 840
atggaagtgc agctggtgga gtcaggtgga ggcttggtgc aaccgggcgg ttcactgcgt       60

ctgtcatgtg cggcgtctgg gtttactttt agtgactctt ggattcactg ggtgcgccag      120

gctccgggta aaggcctgga atgggtagct tggattagtc cttacggtgg ctcgacctat      180

tatgctgatt cggtaaaggg tcgctttact attagcgctg atacttctaa aaatactgca      240

tacctgcaga tgaatagcct gcgcgctgag gatactgctg tgtattattg cgcgcgtcgc      300

cactggccgg gcggctttga ttattggggc caaggtactc tggttaccgt gtctagtggc      360

ggtggtagcg gcggcggctc aggtggcggc tcgggcggtg gcgacattca gatgactcag      420

tctccgtctt ctttgtcggc gagcgtgggc gatcgtgtta ccatcacgtg tcgcgcgagc      480

caagatgtgt cgactgcggt ggcttggtat caacaaaaac cgggtaaagc tccgaaactg      540

ctgatttata gtgcgtcttt tttgtattct ggtgttccgt ctcgtttctc tggctcaggt      600

agcggtactg attttacgct gactatttct tcactgcaac cggaagattt tgctacgtat      660

tattgtcaac aatatctgta tcacccggcg acgtttggtc agggtactaa ggtggagata      720

aaacgcctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtaatttt      780

gatgttaaag aggaaagagc tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      840

ttttcatatg gacggaactc aataactttg acagcatcag cataa                      885


<210> 841
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> C terminal HlyA secretion Tag

<400> 841
cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtaa ttttgatgtt       60

aaagaggaaa gagctgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      120

tatggacgga actcaataac tttgacagca tcagcataa                             159


<210> 842
<211> 2124
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> HlyB coding sequence

<400> 842
atggattctt gtcataaaat tgattatggg ttatacgccc tggagatttt agcccaatac       60

cataacgtct ctgttaaccc ggaagaaatt aaacatagat ttgacacaga cgggactggt      120

ctgggattaa cgtcatggtt gcttgctgcg aaatctttag aactaaaggt aaaacaggta      180

aaaaaaacaa ttgaccgatt aaactttatt tctttgcccg cattagtctg gagagaggat      240

ggacgtcatt ttattctgac taaagtcagt aaagaagcaa acagatatct tatttttgat      300

ctggagcaac gaaatccccg tgttctcgaa cagtctgagt ttgaggcgtt atatcagggg      360

catattattc ttattgcttc ccgttcttct gttaccggga aactggcaaa atttgacttt      420

acctggttta tccctgccat tataaaatac agaaaaatat ttattgaaac ccttgttgta      480

tctgtttttt tacaattatt tgcattaata accccccttt tttttcaggt ggttatggac      540

aaagtattag tacacagggg gttttcaacc cttaatgtta ttactgtcgc attatctgtt      600

gtggtggtgt ttgagattat actcagcggt ttaagaactt acatttttgc acatagtaca      660

agtcggattg atgttgagtt gggtgccaaa ctcttccggc atttactggc gctaccgatc      720

tcttattttg agagtcgtcg tgttggtgat actgttgcca gggtaagaga attagaccag      780

atccgtaatt ttctgacagg acaggcatta acatctgttc tggacttatt attttcattc      840

atattttttg cggtaatgtg gtattacagc ccaaagctta ctctggtgat cttattttcg      900

ctgccctgtt atgctgcatg gtctgttttt attagcccca ttttgcgacg tcgccttgat      960

gataagtttt cacggaatgc ggataatcaa tctttcctgg tggaatcagt cacggcgatt     1020

aacactataa aagctatggc agtctcacct cagatgacga acatatggga caaacaattg     1080

gcaggatatg ttgctgcagg ctttaaagtg acagtattag ccaccattgg tcaacaagga     1140

atacagttaa tacaaaagac tgttatgatc atcaacctgt ggttgggagc acacctggtt     1200

atttccgggg atttaagtat tggtcagtta attgctttta atatgcttgc tggtcagatt     1260

gttgcaccgg ttattcgcct tgcacaaatc tggcaggatt tccagcaggt tggtatatca     1320

gttacccgcc ttggtgatgt gcttaactct ccaactgaaa gttatcatgg gaaactggca     1380

ttaccggaaa ttaatggtaa tatcactttt cgtaatatcc ggtttcgcta taagcctgac     1440

tctccggtta ttttagataa tatcaatctc agtattaagc agggggaggt tattggtatt     1500

gtcggacgtt ctggttcagg aaaaagcaca ttaactaaat taattcaacg tttttatatt     1560

cctgaaaatg gccaggtctt aattgatgga catgatcttg cgttggccga tcctaactgg     1620

ttacgtcgtc aggtgggggt tgtgttgcag gacaatgtgc tgcttaatcg cagtattatt     1680

gataatatct cactggctaa tcctggtatg tccgtcgaaa aagttattta tgcagcgaaa     1740

ttagcaggcg ctcatgattt tatttctgaa ttgcgtgagg ggtataacac cattgtcggg     1800

gaacaggggg caggattatc cggaggtcaa cgtcaacgca tcgcaattgc aagggcgctg     1860

gtgaacaacc ctaaaatact tatttttgat gaagcaacca gtgctctgga ttatgagtcg     1920

gagcatatca tcatgcgcaa tatgcacaaa atatgtaagg gcagaacggt tataatcatt     1980

gctcatcgtc tgtctacagt aaaaaatgca gaccgcatta ttgtcatgga aaaagggaaa     2040

attgttgaac agggtaaaca taaggaactg ctttctgaac cggaaagttt atacagttac     2100

ttatatcagt tacagtcaga ctaa                                            2124


<210> 843
<211> 1437
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> HlyD coding sequence

<400> 843
atgaaaacat ggttaatggg gttcagcgag ttcctgttgc gctataaact tgtctggagt       60

gaaacatgga aaatccggaa gcaattagat actccggtac gtgaaaagga cgaaaatgaa      120

ttcttacccg ctcatctgga attaattgaa acgccggtat ccagacggcc gcgtctggtt      180

gcttatttta ttatggggtt tctggttatt gctgtcattt tatctgtttt aggtcaggtg      240

gaaattgttg ccactgcaaa tgggaaatta acactaagtg ggcgcagcaa agaaattaaa      300

cctattgaaa actcaatagt taaagaaatt atcgtaaaag aaggagagtc agtccggaaa      360

ggggatgtgt tattaaagct tacagcactg ggagctgaag ctgatacgtt aaaaacacag      420

tcatcactgt tacagaccag gctggaacaa actcggtatc aaattctgag caggtcaatt      480

gaattaaata aactacctga actgaagctt cctgatgagc cttattttca gaatgtatct      540

gaagaggaag tactgcgttt aacttctttg ataaaagaac agttttccac atggcaaaat      600

cagaagtatc aaaaagaact gaatctggat aagaaaagag cagagcgatt aacaatactt      660

gcccgtataa accgttatga aaatttatcg agagttgaaa aaagccgtct ggatgatttc      720

aggagtttat tgcataaaca ggcaattgca aaacatgctg tacttgagca ggagaataaa      780

tatgtcgagg cagcaaatga attacgggtt tataaatcgc aactggagca aattgagagt      840

gagatattgt ctgcaaaaga agaatatcag cttgtcacgc agctttttaa aaatgaaatt      900

ttagacaagc taagacaaac aacagacaac attgagttat taactctgga gttagagaaa      960

aatgaagagc gtcaacaggc ttcagtaatc agggcccctg tttcgggaaa agttcagcaa     1020

ctgaaggttc atactgaagg tggggttgtt acaacagcgg aaacactgat ggtcatcgtt     1080

ccggaagatg acacgctgga ggttactgct ctggtacaaa ataaagatat tggttttatt     1140

aacgtcgggc agaatgccat cattaaagtg gaggcctttc cttacacccg atatggttat     1200

ctggtgggta aggtgaaaaa tataaattta gatgcaatag aagaccagaa actgggactc     1260

gtttttaatg tcattgtttc tgttgaagag aatgatttgt caaccgggaa taagcacatt     1320

ccattaagct cgggtatggc tgtcactgca gaaataaaga ctggaatgcg aagcgtaatc     1380

agctatcttc ttagtcctct ggaagagtct gtaacagaaa gtttacatga gcgttaa        1437


<210> 844
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-CTLA-4 Heavy

<400> 844
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          


Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 845
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-CTLA-4 Light

<400> 845
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 846
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-PD-1 Heavy

<400> 846
Met Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn 
            20                  25                  30          


Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
65                  70                  75                  80  


Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210> 847
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-PD-1 Light

<400> 847
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 848
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-PD-L1 Light

<400> 848
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro 
                85                  90                  95      


Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210> 849
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Anti-PD-L1 Heavy

<400> 849
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 850
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Linker

<400> 850
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210> 851
<211> 59
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> N Terminal Secretion Tag For Type V Auto-secreter
      Secretion

<400> 851
Met Asn Lys Val Tyr Ser Leu Lys Tyr Cys Pro Val Thr Gly Gly Leu 
1               5                   10                  15      


Ile Val Val Ser Glu Leu Ala Ser Arg Val Ile Lys Lys Thr Cys Arg 
            20                  25                  30          


Arg Leu Thr His Ile Leu Leu Ala Gly Ile Pro Ala Val Tyr Leu Tyr 
        35                  40                  45              


Tyr Pro Gln Ile Ser Gln Ala Gly Ile Val Arg 
    50                  55                  


<210> 852
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> C Terminal Secretion Tag For Type V Auto-secreter
      Secretion

<400> 852
Phe Lys Ala Glu Ala Asp Lys Ala Ala Ala Ala Lys Ala Asp Ser Phe 
1               5                   10                  15      


Met Asn Ala Gly Tyr Lys Asn Phe Met Thr Glu Val Asn Asn Leu Asn 
            20                  25                  30          


Lys Arg Met Gly Asp Leu Arg Asp Thr Asn Gly Asp Ala Gly Ala Trp 
        35                  40                  45              


Ala Arg Ile Met Ser Gly Ala Gly Ser Ala Asp Gly Gly Tyr Ser Asp 
    50                  55                  60                  


Asn Tyr Thr His Val Gln Val Gly Phe Asp Lys Lys His Glu Leu Asp 
65                  70                  75                  80  


Gly Val Asp Leu Phe Thr Gly Val Thr Met Thr Tyr Thr Asp Ser Ser 
                85                  90                  95      


Ala Asp Ser His Ala Phe Ser Gly Lys Thr Lys Ser Val Gly Gly Gly 
            100                 105                 110         


Leu Tyr Ala Ser Ala Leu Phe Glu Ser Gly Ala Tyr Ile Asp Leu Ile 
        115                 120                 125             


Gly Lys Tyr Ile His His Asp Asn Asp Tyr Thr Gly Asn Phe Ala Gly 
    130                 135                 140                 


Leu Gly Thr Lys His Tyr Asn Thr His Ser Trp Tyr Ala Gly Ala Glu 
145                 150                 155                 160 


Thr Gly 
        


<210> 853
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> C-Terminal HlyA Secretion Tag

<400> 853
Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
1               5                   10                  15      


Asn Phe Asp Val Lys Glu Glu Arg Ala Ala Ala Ser Leu Leu Gln Leu 
            20                  25                  30          


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
        35                  40                  45              


Thr Ala Ser Ala 
    50          


<210> 854
<211> 707
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> HlyB

<400> 854
Met Asp Ser Cys His Lys Ile Asp Tyr Gly Leu Tyr Ala Leu Glu Ile 
1               5                   10                  15      


Leu Ala Gln Tyr His Asn Val Ser Val Asn Pro Glu Glu Ile Lys His 
            20                  25                  30          


Arg Phe Asp Thr Asp Gly Thr Gly Leu Gly Leu Thr Ser Trp Leu Leu 
        35                  40                  45              


Ala Ala Lys Ser Leu Glu Leu Lys Val Lys Gln Val Lys Lys Thr Ile 
    50                  55                  60                  


Asp Arg Leu Asn Phe Ile Ser Leu Pro Ala Leu Val Trp Arg Glu Asp 
65                  70                  75                  80  


Gly Arg His Phe Ile Leu Thr Lys Val Ser Lys Glu Ala Asn Arg Tyr 
                85                  90                  95      


Leu Ile Phe Asp Leu Glu Gln Arg Asn Pro Arg Val Leu Glu Gln Ser 
            100                 105                 110         


Glu Phe Glu Ala Leu Tyr Gln Gly His Ile Ile Leu Ile Ala Ser Arg 
        115                 120                 125             


Ser Ser Val Thr Gly Lys Leu Ala Lys Phe Asp Phe Thr Trp Phe Ile 
    130                 135                 140                 


Pro Ala Ile Ile Lys Tyr Arg Lys Ile Phe Ile Glu Thr Leu Val Val 
145                 150                 155                 160 


Ser Val Phe Leu Gln Leu Phe Ala Leu Ile Thr Pro Leu Phe Phe Gln 
                165                 170                 175     


Val Val Met Asp Lys Val Leu Val His Arg Gly Phe Ser Thr Leu Asn 
            180                 185                 190         


Val Ile Thr Val Ala Leu Ser Val Val Val Val Phe Glu Ile Ile Leu 
        195                 200                 205             


Ser Gly Leu Arg Thr Tyr Ile Phe Ala His Ser Thr Ser Arg Ile Asp 
    210                 215                 220                 


Val Glu Leu Gly Ala Lys Leu Phe Arg His Leu Leu Ala Leu Pro Ile 
225                 230                 235                 240 


Ser Tyr Phe Glu Ser Arg Arg Val Gly Asp Thr Val Ala Arg Val Arg 
                245                 250                 255     


Glu Leu Asp Gln Ile Arg Asn Phe Leu Thr Gly Gln Ala Leu Thr Ser 
            260                 265                 270         


Val Leu Asp Leu Leu Phe Ser Phe Ile Phe Phe Ala Val Met Trp Tyr 
        275                 280                 285             


Tyr Ser Pro Lys Leu Thr Leu Val Ile Leu Phe Ser Leu Pro Cys Tyr 
    290                 295                 300                 


Ala Ala Trp Ser Val Phe Ile Ser Pro Ile Leu Arg Arg Arg Leu Asp 
305                 310                 315                 320 


Asp Lys Phe Ser Arg Asn Ala Asp Asn Gln Ser Phe Leu Val Glu Ser 
                325                 330                 335     


Val Thr Ala Ile Asn Thr Ile Lys Ala Met Ala Val Ser Pro Gln Met 
            340                 345                 350         


Thr Asn Ile Trp Asp Lys Gln Leu Ala Gly Tyr Val Ala Ala Gly Phe 
        355                 360                 365             


Lys Val Thr Val Leu Ala Thr Ile Gly Gln Gln Gly Ile Gln Leu Ile 
    370                 375                 380                 


Gln Lys Thr Val Met Ile Ile Asn Leu Trp Leu Gly Ala His Leu Val 
385                 390                 395                 400 


Ile Ser Gly Asp Leu Ser Ile Gly Gln Leu Ile Ala Phe Asn Met Leu 
                405                 410                 415     


Ala Gly Gln Ile Val Ala Pro Val Ile Arg Leu Ala Gln Ile Trp Gln 
            420                 425                 430         


Asp Phe Gln Gln Val Gly Ile Ser Val Thr Arg Leu Gly Asp Val Leu 
        435                 440                 445             


Asn Ser Pro Thr Glu Ser Tyr His Gly Lys Leu Ala Leu Pro Glu Ile 
    450                 455                 460                 


Asn Gly Asn Ile Thr Phe Arg Asn Ile Arg Phe Arg Tyr Lys Pro Asp 
465                 470                 475                 480 


Ser Pro Val Ile Leu Asp Asn Ile Asn Leu Ser Ile Lys Gln Gly Glu 
                485                 490                 495     


Val Ile Gly Ile Val Gly Arg Ser Gly Ser Gly Lys Ser Thr Leu Thr 
            500                 505                 510         


Lys Leu Ile Gln Arg Phe Tyr Ile Pro Glu Asn Gly Gln Val Leu Ile 
        515                 520                 525             


Asp Gly His Asp Leu Ala Leu Ala Asp Pro Asn Trp Leu Arg Arg Gln 
    530                 535                 540                 


Val Gly Val Val Leu Gln Asp Asn Val Leu Leu Asn Arg Ser Ile Ile 
545                 550                 555                 560 


Asp Asn Ile Ser Leu Ala Asn Pro Gly Met Ser Val Glu Lys Val Ile 
                565                 570                 575     


Tyr Ala Ala Lys Leu Ala Gly Ala His Asp Phe Ile Ser Glu Leu Arg 
            580                 585                 590         


Glu Gly Tyr Asn Thr Ile Val Gly Glu Gln Gly Ala Gly Leu Ser Gly 
        595                 600                 605             


Gly Gln Arg Gln Arg Ile Ala Ile Ala Arg Ala Leu Val Asn Asn Pro 
    610                 615                 620                 


Lys Ile Leu Ile Phe Asp Glu Ala Thr Ser Ala Leu Asp Tyr Glu Ser 
625                 630                 635                 640 


Glu His Ile Ile Met Arg Asn Met His Lys Ile Cys Lys Gly Arg Thr 
                645                 650                 655     


Val Ile Ile Ile Ala His Arg Leu Ser Thr Val Lys Asn Ala Asp Arg 
            660                 665                 670         


Ile Ile Val Met Glu Lys Gly Lys Ile Val Glu Gln Gly Lys His Lys 
        675                 680                 685             


Glu Leu Leu Ser Glu Pro Glu Ser Leu Tyr Ser Tyr Leu Tyr Gln Leu 
    690                 695                 700                 


Gln Ser Asp 
705         


<210> 855
<211> 478
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> HlyD

<400> 855
Met Lys Thr Trp Leu Met Gly Phe Ser Glu Phe Leu Leu Arg Tyr Lys 
1               5                   10                  15      


Leu Val Trp Ser Glu Thr Trp Lys Ile Arg Lys Gln Leu Asp Thr Pro 
            20                  25                  30          


Val Arg Glu Lys Asp Glu Asn Glu Phe Leu Pro Ala His Leu Glu Leu 
        35                  40                  45              


Ile Glu Thr Pro Val Ser Arg Arg Pro Arg Leu Val Ala Tyr Phe Ile 
    50                  55                  60                  


Met Gly Phe Leu Val Ile Ala Val Ile Leu Ser Val Leu Gly Gln Val 
65                  70                  75                  80  


Glu Ile Val Ala Thr Ala Asn Gly Lys Leu Thr Leu Ser Gly Arg Ser 
                85                  90                  95      


Lys Glu Ile Lys Pro Ile Glu Asn Ser Ile Val Lys Glu Ile Ile Val 
            100                 105                 110         


Lys Glu Gly Glu Ser Val Arg Lys Gly Asp Val Leu Leu Lys Leu Thr 
        115                 120                 125             


Ala Leu Gly Ala Glu Ala Asp Thr Leu Lys Thr Gln Ser Ser Leu Leu 
    130                 135                 140                 


Gln Thr Arg Leu Glu Gln Thr Arg Tyr Gln Ile Leu Ser Arg Ser Ile 
145                 150                 155                 160 


Glu Leu Asn Lys Leu Pro Glu Leu Lys Leu Pro Asp Glu Pro Tyr Phe 
                165                 170                 175     


Gln Asn Val Ser Glu Glu Glu Val Leu Arg Leu Thr Ser Leu Ile Lys 
            180                 185                 190         


Glu Gln Phe Ser Thr Trp Gln Asn Gln Lys Tyr Gln Lys Glu Leu Asn 
        195                 200                 205             


Leu Asp Lys Lys Arg Ala Glu Arg Leu Thr Ile Leu Ala Arg Ile Asn 
    210                 215                 220                 


Arg Tyr Glu Asn Leu Ser Arg Val Glu Lys Ser Arg Leu Asp Asp Phe 
225                 230                 235                 240 


Arg Ser Leu Leu His Lys Gln Ala Ile Ala Lys His Ala Val Leu Glu 
                245                 250                 255     


Gln Glu Asn Lys Tyr Val Glu Ala Ala Asn Glu Leu Arg Val Tyr Lys 
            260                 265                 270         


Ser Gln Leu Glu Gln Ile Glu Ser Glu Ile Leu Ser Ala Lys Glu Glu 
        275                 280                 285             


Tyr Gln Leu Val Thr Gln Leu Phe Lys Asn Glu Ile Leu Asp Lys Leu 
    290                 295                 300                 


Arg Gln Thr Thr Asp Asn Ile Glu Leu Leu Thr Leu Glu Leu Glu Lys 
305                 310                 315                 320 


Asn Glu Glu Arg Gln Gln Ala Ser Val Ile Arg Ala Pro Val Ser Gly 
                325                 330                 335     


Lys Val Gln Gln Leu Lys Val His Thr Glu Gly Gly Val Val Thr Thr 
            340                 345                 350         


Ala Glu Thr Leu Met Val Ile Val Pro Glu Asp Asp Thr Leu Glu Val 
        355                 360                 365             


Thr Ala Leu Val Gln Asn Lys Asp Ile Gly Phe Ile Asn Val Gly Gln 
    370                 375                 380                 


Asn Ala Ile Ile Lys Val Glu Ala Phe Pro Tyr Thr Arg Tyr Gly Tyr 
385                 390                 395                 400 


Leu Val Gly Lys Val Lys Asn Ile Asn Leu Asp Ala Ile Glu Asp Gln 
                405                 410                 415     


Lys Leu Gly Leu Val Phe Asn Val Ile Val Ser Val Glu Glu Asn Asp 
            420                 425                 430         


Leu Ser Thr Gly Asn Lys His Ile Pro Leu Ser Ser Gly Met Ala Val 
        435                 440                 445             


Thr Ala Glu Ile Lys Thr Gly Met Arg Ser Val Ile Ser Tyr Leu Leu 
    450                 455                 460                 


Ser Pro Leu Glu Glu Ser Val Thr Glu Ser Leu His Glu Arg 
465                 470                 475             


<210> 856
<211> 213
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> PfnrS

<400> 856
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata cat                                   213


<210> 857
<211> 1455
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> PfnrS-nupC

<400> 857
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata catgtgcacg gaaatttaac ctgcctcata      240

tttggagcaa atatggaccg cgtccttcat tttgtactgg cacttgccgt tgttgcgatt      300

ctcgcactgc tggtaagcag cgaccgcaaa aaaattcgta tccgttatgt tattcaactg      360

cttgttatcg aagtgttact ggcgtggttc ttcctgaact ccgacgttgg tctgggcttc      420

gtgaaaggct tctccgaaat gttcgaaaaa ctgctcggtt ttgccaacga agggactaac      480

ttcgtctttg gtagcatgaa tgatcaaggc ctggcattct tcttcctgaa agtgctgtgc      540

ccaatcgtct ttatctctgc gctgatcggt attctccagc atattcgcgt attgccggtg      600

attatccgcg caattggttt cctgctctcc aaagtcaacg gcatgggcaa actggaatcc      660

tttaacgccg tcagctccct gattctgggt cagtctgaaa actttattgc ctataaagat      720

atcctcggca aaatctcccg caatcgtatg tacaccatgg cagcaacggc gatgtccacc      780

gtgtcgatgt ccatcgttgg tgcatatatg accatgctgg agccgaaata cgtcgttgcg      840

gcgctggtac tgaacatgtt cagcaccttt atcgtgctgt cgctgatcaa cccttaccgt      900

gttgatgcca gtgaagaaaa cattcagatg tccaacctgc acgaaggtca gagcttcttc      960

gaaatgctgg gtgaatacat tctggcaggt ttcaaagttg ccattatcgt tgccgcgatg     1020

ctgatcggct ttatcgccct gatcgctgca ctgaacgctc tgtttgctac cgtgactggc     1080

tggtttggct acagcatctc cttccagggc atcctgggtt acatcttcta tccgattgca     1140

tgggtgatgg gtgttccttc cagtgaagca ctgcaagtgg gcagtatcat ggcgaccaaa     1200

ctggtttcca acgagttcgt tgcgatgatg gatctgcaga aaattgcttc cacgctctct     1260

ccgcgtgcgg aaggcatcat ctctgtgttc ctggtttcct tcgctaactt ctcttcaatc     1320

gggattatcg cgggtgcggt taaaggcctg aatgaagagc aaggtaacgt ggtttctcgc     1380

ttcggtctga aactggttta cggctctacc ctggtgagtg tgctgtctgc gtcaatcgca     1440

gcactggtgc tgtaa                                                      1455


<210> 858
<211> 3837
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> PfnrS-xdhABC

<400> 858
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata catatgcgcg tcgatgccat tgctaaggtc      240

accgggcggg cacgatatac tgacgattat attatggcgg gcatgtgtta cgcgaaatat      300

gtacgtagcc ctatcgcaca tggttatgct gtaaatatta atgatgaaca agccaggagt      360

ttgccgggcg tcctggcgat ttttacctgg gaagatgtgc cagaaatccc attcgccacg      420

gcagggcatg cctggacact tgacgaaaac aagcgcgata ccgccgatcg tgccctgcta      480

acgcgtcatg ttcgtcatca tggtgacgcc gttgccatcg tcgtggcccg cgatgaactc      540

acggcagaaa aagcggcgca attggtcagc attgagtggc aagaattacc cgttatcacc      600

tcgccagaag cggcgctggc agaagacgct gcaccaatcc ataacggtgg caatttactg      660

aaacaaagca cgatgtcgac gggtaatgtc caacaaacaa tcgatgccgc cgactaccag      720

gtacaggggc actatcagac tcccgttatt caacattgtc atatggaaag cgtgacatcg      780

ctggcatgga tggaggatga ctcgcgaatt accatcgttt ccagcaccca gatcccgcac      840

attgttcgcc gcgtggttgg tcaggcgctg gatattccct ggtcatgcgt acgagtcatc      900

aaaccgttta tcggtggcgg ttttggtaat aaacaggatg tactggaaga gccaatggcg      960

gcattcctga ccagcaaact tggcggcatt ccggtgaaag tttcccttag ccgtgaagag     1020

tgtttcctcg caacccgtac ccgccacgct tttactattg acgggcaaat gggcgtgaac     1080

cgcgacggaa cattgaaagg ttatagtctg gatgttctgt ctaacaccgg cgcttatgca     1140

tctcacgggc actccattgc ttctgctggg gggaataaag tcgcttacct ttatcctcgt     1200

tgtgcctacg cttacagttc aaagacctgc tataccaacc tcccctcggc tggtgcgatg     1260

cgtggttatg gcgcgccaca agtcgtattt gccgttgagt ctatgcttga tgatgccgcg     1320

acagcgttag gtattgatcc tgttgaaatt cgtttacgca acgccgcccg cgaaggagat     1380

gctaatccgc tcacgggaaa acgtatttac agcgcagggt tgccggagtg tcttgaaaaa     1440

ggccggaaaa tctttgaatg ggaaaaacgc cgtgcagagt gccagaacca gcaaggcaat     1500

ttacgtcgtg gcgttggcgt cgcctgtttt agctacacct ctaacacctg gcctgtcggc     1560

gtagaaatag caggcgcgcg cctgttgatg aatcaggatg gaaccatcaa cgtgcaaagc     1620

ggcgcgacgg aaatcggcca gggtgccgac accgtgttct cgcaaatggt ggcagaaacc     1680

gtgggagttc cggtcagcga tgttcacgtt atttcaaccc aagataccga cgttacacca     1740

ttcgaccccg gcgcatttgc ctcacgtcag agctatgttg ccgcgcctgc gctgcgcagt     1800

gcagcactgt tattaaaaga gaaaatcatc gctcacgccg cagtcatgct acatcagtca     1860

gcgatgaatc tgaccctgat aaaaggccat atcgtgctga ttgaaagacc ggaagaaccg     1920

ttaatgtcgt taaaagattt ggcgatggac gctttctacc accctgaacg cggcgggcag     1980

ctctctgccg aaagctccat caaaaccacc actaacccac cggcgtttgg ctgtaccttt     2040

gttgatctga cggtcgatat tgcactgtgc aaagtcacca tcaaccgcat cctcaacgtt     2100

catgattcgg gccatattct taatccgctg ctggcagaag gtcaggtaca cggcggaatg     2160

ggaatgggca ttggctgggc gctatttgaa gagatgatca tcgatgcgaa aagcggcgtg     2220

gtccgtaacc ccaatctgct ggattacaaa atgccgacca tgccggatct gccacaactg     2280

gaaagcgcgt tcgtcgaaat caatgagccg caatcagcat acggacataa gtcactgggt     2340

gagcccccca taattcctgt agccgctgct attcgtaacg cggtgaagat ggctaccggt     2400

gttgcaatca atacactgcc gctaacgcca aaacgattat atgaagaatt ccatctggca     2460

ggattgattt gaggataaca tcatgtttga ttttgcttct taccatcgcg caaccaccct     2520

tgccgatgcc atcaccctgc tggctgacaa tccgcaggcc aaattgcttg ccggtggcac     2580

tgacgtactg atacagcttc accatcacaa tgaccgctat cgccatattg ttgatatcca     2640

caatctggca gagcttcagg gaataacaca ggcggaagat ggcgcgctgc gaatcggctc     2700

tgcgacaaca tttactcagc tcattgaaga tcccgtaatc caacgcaatc tcccggcgtt     2760

atgtgctgcg gctgcatcaa tcgccgggcc gcagatccgt aatgtcgcca cctacggcgg     2820

aaatatttgc aacggtgcca ccagcgcaga ttctgccacg ccaacgctaa tttatgacgc     2880

gaaactggag ctccactccc cacgcggtgt tcgtttcgtc ccgattaatg gctttcacac     2940

cgggccgggc aaagtgtctc ttgagcatga cgaaatcctt gtcgcctttc attttccgcc     3000

acagccgaaa gaacacgcgg gcagcgcgca ttttaaatat gccatgcgcg acgcaatgga     3060

tatttcaaca attggctgcg ccgcacattg ccgactggat aacggcaatt tcagcgaatt     3120

acgcctggca tttggtgttg ccgcgccaac gccgattcgc tgccaacatg ccgaacagac     3180

tgcacaaaat gcgccattaa acctgcaaac gctggaagcc atcagcgaat cagtcctgca     3240

agatgtcgcc ccgcgttctt catggcgggc cagtaaagag tttcgtctgc atctcatcca     3300

gacgatgacc aaaaaagtga ttagcgaagc cgtcgccgcg gcggggggaa aattgcaatg     3360

aatcacagcg aaacaattac catcgaatgc accattaacg ggatgccttt tcagcttcac     3420

gccgcgccag gaatgccgct ttcggaacta ctccgagaac aagggcttct tagtgtcaaa     3480

caaggttgct gcgtaggcga atgcggtgcc tgtacggtgc tggtcgacgg cactgcgata     3540

gacagttgct tattccttgc gacctgggct gaaggaaaag agatccgcac gctggaaggt     3600

gaagcgaaag gcggtaaact ttctcatgtc caactggctt atgcgaaatc tggtgcagtg     3660

caatgcgggt tttgtacgcc gggcctgatt atggctacca cggcgatgct ggcaaaacca     3720

cgcgaaaaac cattaaccat tacggaaatt cgtcgtggac tggcgggaaa tctttgtcgc     3780

tgcacggggt atcagatgat tgtaaataca gttctggatt gcgagaaaac gaagtaa        3837


<210> 859
<211> 3624
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> xdhABC

<400> 859
atgcgcgtcg atgccattgc taaggtcacc gggcgggcac gatatactga cgattatatt       60

atggcgggca tgtgttacgc gaaatatgta cgtagcccta tcgcacatgg ttatgctgta      120

aatattaatg atgaacaagc caggagtttg ccgggcgtcc tggcgatttt tacctgggaa      180

gatgtgccag aaatcccatt cgccacggca gggcatgcct ggacacttga cgaaaacaag      240

cgcgataccg ccgatcgtgc cctgctaacg cgtcatgttc gtcatcatgg tgacgccgtt      300

gccatcgtcg tggcccgcga tgaactcacg gcagaaaaag cggcgcaatt ggtcagcatt      360

gagtggcaag aattacccgt tatcacctcg ccagaagcgg cgctggcaga agacgctgca      420

ccaatccata acggtggcaa tttactgaaa caaagcacga tgtcgacggg taatgtccaa      480

caaacaatcg atgccgccga ctaccaggta caggggcact atcagactcc cgttattcaa      540

cattgtcata tggaaagcgt gacatcgctg gcatggatgg aggatgactc gcgaattacc      600

atcgtttcca gcacccagat cccgcacatt gttcgccgcg tggttggtca ggcgctggat      660

attccctggt catgcgtacg agtcatcaaa ccgtttatcg gtggcggttt tggtaataaa      720

caggatgtac tggaagagcc aatggcggca ttcctgacca gcaaacttgg cggcattccg      780

gtgaaagttt cccttagccg tgaagagtgt ttcctcgcaa cccgtacccg ccacgctttt      840

actattgacg ggcaaatggg cgtgaaccgc gacggaacat tgaaaggtta tagtctggat      900

gttctgtcta acaccggcgc ttatgcatct cacgggcact ccattgcttc tgctgggggg      960

aataaagtcg cttaccttta tcctcgttgt gcctacgctt acagttcaaa gacctgctat     1020

accaacctcc cctcggctgg tgcgatgcgt ggttatggcg cgccacaagt cgtatttgcc     1080

gttgagtcta tgcttgatga tgccgcgaca gcgttaggta ttgatcctgt tgaaattcgt     1140

ttacgcaacg ccgcccgcga aggagatgct aatccgctca cgggaaaacg tatttacagc     1200

gcagggttgc cggagtgtct tgaaaaaggc cggaaaatct ttgaatggga aaaacgccgt     1260

gcagagtgcc agaaccagca aggcaattta cgtcgtggcg ttggcgtcgc ctgttttagc     1320

tacacctcta acacctggcc tgtcggcgta gaaatagcag gcgcgcgcct gttgatgaat     1380

caggatggaa ccatcaacgt gcaaagcggc gcgacggaaa tcggccaggg tgccgacacc     1440

gtgttctcgc aaatggtggc agaaaccgtg ggagttccgg tcagcgatgt tcacgttatt     1500

tcaacccaag ataccgacgt tacaccattc gaccccggcg catttgcctc acgtcagagc     1560

tatgttgccg cgcctgcgct gcgcagtgca gcactgttat taaaagagaa aatcatcgct     1620

cacgccgcag tcatgctaca tcagtcagcg atgaatctga ccctgataaa aggccatatc     1680

gtgctgattg aaagaccgga agaaccgtta atgtcgttaa aagatttggc gatggacgct     1740

ttctaccacc ctgaacgcgg cgggcagctc tctgccgaaa gctccatcaa aaccaccact     1800

aacccaccgg cgtttggctg tacctttgtt gatctgacgg tcgatattgc actgtgcaaa     1860

gtcaccatca accgcatcct caacgttcat gattcgggcc atattcttaa tccgctgctg     1920

gcagaaggtc aggtacacgg cggaatggga atgggcattg gctgggcgct atttgaagag     1980

atgatcatcg atgcgaaaag cggcgtggtc cgtaacccca atctgctgga ttacaaaatg     2040

ccgaccatgc cggatctgcc acaactggaa agcgcgttcg tcgaaatcaa tgagccgcaa     2100

tcagcatacg gacataagtc actgggtgag ccccccataa ttcctgtagc cgctgctatt     2160

cgtaacgcgg tgaagatggc taccggtgtt gcaatcaata cactgccgct aacgccaaaa     2220

cgattatatg aagaattcca tctggcagga ttgatttgag gataacatca tgtttgattt     2280

tgcttcttac catcgcgcaa ccacccttgc cgatgccatc accctgctgg ctgacaatcc     2340

gcaggccaaa ttgcttgccg gtggcactga cgtactgata cagcttcacc atcacaatga     2400

ccgctatcgc catattgttg atatccacaa tctggcagag cttcagggaa taacacaggc     2460

ggaagatggc gcgctgcgaa tcggctctgc gacaacattt actcagctca ttgaagatcc     2520

cgtaatccaa cgcaatctcc cggcgttatg tgctgcggct gcatcaatcg ccgggccgca     2580

gatccgtaat gtcgccacct acggcggaaa tatttgcaac ggtgccacca gcgcagattc     2640

tgccacgcca acgctaattt atgacgcgaa actggagctc cactccccac gcggtgttcg     2700

tttcgtcccg attaatggct ttcacaccgg gccgggcaaa gtgtctcttg agcatgacga     2760

aatccttgtc gcctttcatt ttccgccaca gccgaaagaa cacgcgggca gcgcgcattt     2820

taaatatgcc atgcgcgacg caatggatat ttcaacaatt ggctgcgccg cacattgccg     2880

actggataac ggcaatttca gcgaattacg cctggcattt ggtgttgccg cgccaacgcc     2940

gattcgctgc caacatgccg aacagactgc acaaaatgcg ccattaaacc tgcaaacgct     3000

ggaagccatc agcgaatcag tcctgcaaga tgtcgccccg cgttcttcat ggcgggccag     3060

taaagagttt cgtctgcatc tcatccagac gatgaccaaa aaagtgatta gcgaagccgt     3120

cgccgcggcg gggggaaaat tgcaatgaat cacagcgaaa caattaccat cgaatgcacc     3180

attaacggga tgccttttca gcttcacgcc gcgccaggaa tgccgctttc ggaactactc     3240

cgagaacaag ggcttcttag tgtcaaacaa ggttgctgcg taggcgaatg cggtgcctgt     3300

acggtgctgg tcgacggcac tgcgatagac agttgcttat tccttgcgac ctgggctgaa     3360

ggaaaagaga tccgcacgct ggaaggtgaa gcgaaaggcg gtaaactttc tcatgtccaa     3420

ctggcttatg cgaaatctgg tgcagtgcaa tgcgggtttt gtacgccggg cctgattatg     3480

gctaccacgg cgatgctggc aaaaccacgc gaaaaaccat taaccattac ggaaattcgt     3540

cgtggactgg cgggaaatct ttgtcgctgc acggggtatc agatgattgt aaatacagtt     3600

ctggattgcg agaaaacgaa gtaa                                            3624


<210> 860
<211> 2803
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> PfnrS-add-xapA-deoD

<400> 860
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gtaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat ccaaagtgaa ctctagaaat      180

aattttgttt aactttaaga aggagatata catatgattg ataccaccct gccattaact      240

gatatccatc gccaccttga tggcaacatt cgtccccaga ccattcttga acttggccgc      300

cagtataata tctcgcttcc tgcacaatcc ctggaaacac tgattcccca cgttcaggtc      360

attgccaacg aacccgatct ggtgagcttt ctgactaaac ttgactgggg cgttaaagtt      420

ctcgcctctc ttgatgcctg ccgccgcgtg gcatttgaaa acattgaaga tgcagcccgt      480

aacggcctgc actatgtcga gctgcgtttt tcaccaggct acatggcaat ggcacatcag      540

ctgcctgtag cgggtgttgt cgaagcggtg atcgatggcg tacgtgaagg ttgccgcacc      600

tttggtgtgc aggcgaagct tatcggtatt atgagccgga ccttcggcga agccgcctgt      660

cagcaagagc tggaggcctt tttagcccac cgtgaccaga ttaccgcact tgatttagcc      720

ggtgatgaac ttggtttccc gggaagtctg ttcctttctc atttcaaccg cgcgcgtgat      780

gcgggctggc atattaccgt ccatgcaggc gaagctgccg gaccggaaag catctggcag      840

gcgattcgtg aactgggggc ggagcgtatt ggacatggcg taaaagccat tgaagatcgg      900

gcgctgatgg attttctcgc cgagcaacaa attggtattg aatcctgtct gacctccaat      960

attcagacca gcaccgtggc ggatctggct gcacatccgc tgaaaacgtt ccttgagcat     1020

ggcattcgtg ccagcattaa cactgacgat ccaggcgtgc agggagtgga tatcattcac     1080

gaatataccg ttgccgcgcc agctgctggg ttatcccgcg agcaaatccg ccaggcacag     1140

attaatggtc tggaaatggc tttcctcagc gcagaggaaa aacgcgcact gcgagaaaaa     1200

gtcgccgcga agtaaaagaa ggagatatac atatgtatca ggctcagttt tctcataacc     1260

cactgtattg cgtagatatt atcaagactt ataaacctga tttcacgcca cgagtggcct     1320

ttattttagg ttccgggctg ggcgcgctgg ccgatcagat tgagaacgcg gtcgcaattt     1380

cctacgaaaa gctgcctggg ttcccggtaa gtaccgtaca cggtcatgcg ggtgagctgg     1440

tgctgggtta tctccagggg gtgccagtgg cgtgtatgaa aggtcgcgga catttctacg     1500

aaggtcgtgg gatgaccatc atgacggatg caatccgtac ctttaagttg ctgggctgcg     1560

agttgctgtt ctgcaccaat gcggctggct cactgcgccc tgaagtgggg gccggcagtc     1620

tggtcgcatt gaaagatcac atcaacacca tgccgggaac gccgatggtg ggtcttaatg     1680

atgaacgttt tggtgagcgc ttcttctcgc tggcgaatgc ctacgatgcg gaataccgcg     1740

cactgttaca aaaagtggcg aaagaagagg ggttccctct gacggagggc gtgttcgtct     1800

catatccggg gccgaatttc gagactgcgg cggaaattcg catgatgcaa attattggtg     1860

gggatgttgt tggtatgtct gtggtgcctg aggttatttc agctcgccat tgcgaactta     1920

aagtcgttgc ggtctctgcg attaccaaca tggcggaagg tctgagtgac gtgaagcttt     1980

ctcatgccca aacgctggca gcagcggaac tctcaaagca aaactttatt aatcttattt     2040

gcggctttct gcgcaaaatt gcctgaaaga aggagatata catatggcta ccccacacat     2100

taatgcagaa atgggcgatt tcgctgacgt agttttgatg ccaggcgacc cgctgcgtgc     2160

gaagtatatt gctgaaactt tccttgaaga tgcccgtgaa gtgaacaacg ttcgcggtat     2220

gctgggcttc accggtactt acaaaggccg caaaatttcc gtaatgggtc acggtatggg     2280

tatcccgtcc tgctccatct acaccaaaga actgatcacc gatttcggcg tgaagaaaat     2340

tatccgcgtg ggttcctgtg gcgcagttct gccgcacgta aaactacgcg acgtcgttat     2400

cggtatgggt gcctgcaccg attccaaagt taaccgcatc cgttttaaag accatgactt     2460

tgccgctatc gctgactttg acatggtgcg taacgcggta gacgcggcta aagcactggg     2520

cgttgatgct cgcgtgggta acctgttctc cgctgacctg ttctactctc cggacggcga     2580

aatgttcgac gtgatggaaa aatacggcat cctcggcgtg gaaatggaag cggctggtat     2640

ctacggcgtc gctgcagaat ttggcgcgaa agccctgacc atctgcaccg tgtctgacca     2700

catccgcact cacgagcaga ccactgccgc tgagcgtcag accaccttca acgacatgat     2760

caaaatcgca ctggaatccg ttctgctggg cgataaagag taa                       2803


<210> 861
<211> 2633
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> add-xapA-deoD

<400> 861
ctctagaaat aattttgttt aactttaaga aggagatata catatgattg ataccaccct       60

gccattaact gatatccatc gccaccttga tggcaacatt cgtccccaga ccattcttga      120

acttggccgc cagtataata tctcgcttcc tgcacaatcc ctggaaacac tgattcccca      180

cgttcaggtc attgccaacg aacccgatct ggtgagcttt ctgactaaac ttgactgggg      240

cgttaaagtt ctcgcctctc ttgatgcctg ccgccgcgtg gcatttgaaa acattgaaga      300

tgcagcccgt aacggcctgc actatgtcga gctgcgtttt tcaccaggct acatggcaat      360

ggcacatcag ctgcctgtag cgggtgttgt cgaagcggtg atcgatggcg tacgtgaagg      420

ttgccgcacc tttggtgtgc aggcgaagct tatcggtatt atgagccgga ccttcggcga      480

agccgcctgt cagcaagagc tggaggcctt tttagcccac cgtgaccaga ttaccgcact      540

tgatttagcc ggtgatgaac ttggtttccc gggaagtctg ttcctttctc atttcaaccg      600

cgcgcgtgat gcgggctggc atattaccgt ccatgcaggc gaagctgccg gaccggaaag      660

catctggcag gcgattcgtg aactgggggc ggagcgtatt ggacatggcg taaaagccat      720

tgaagatcgg gcgctgatgg attttctcgc cgagcaacaa attggtattg aatcctgtct      780

gacctccaat attcagacca gcaccgtggc ggatctggct gcacatccgc tgaaaacgtt      840

ccttgagcat ggcattcgtg ccagcattaa cactgacgat ccaggcgtgc agggagtgga      900

tatcattcac gaatataccg ttgccgcgcc agctgctggg ttatcccgcg agcaaatccg      960

ccaggcacag attaatggtc tggaaatggc tttcctcagc gcagaggaaa aacgcgcact     1020

gcgagaaaaa gtcgccgcga agtaaaagaa ggagatatac atatgtatca ggctcagttt     1080

tctcataacc cactgtattg cgtagatatt atcaagactt ataaacctga tttcacgcca     1140

cgagtggcct ttattttagg ttccgggctg ggcgcgctgg ccgatcagat tgagaacgcg     1200

gtcgcaattt cctacgaaaa gctgcctggg ttcccggtaa gtaccgtaca cggtcatgcg     1260

ggtgagctgg tgctgggtta tctccagggg gtgccagtgg cgtgtatgaa aggtcgcgga     1320

catttctacg aaggtcgtgg gatgaccatc atgacggatg caatccgtac ctttaagttg     1380

ctgggctgcg agttgctgtt ctgcaccaat gcggctggct cactgcgccc tgaagtgggg     1440

gccggcagtc tggtcgcatt gaaagatcac atcaacacca tgccgggaac gccgatggtg     1500

ggtcttaatg atgaacgttt tggtgagcgc ttcttctcgc tggcgaatgc ctacgatgcg     1560

gaataccgcg cactgttaca aaaagtggcg aaagaagagg ggttccctct gacggagggc     1620

gtgttcgtct catatccggg gccgaatttc gagactgcgg cggaaattcg catgatgcaa     1680

attattggtg gggatgttgt tggtatgtct gtggtgcctg aggttatttc agctcgccat     1740

tgcgaactta aagtcgttgc ggtctctgcg attaccaaca tggcggaagg tctgagtgac     1800

gtgaagcttt ctcatgccca aacgctggca gcagcggaac tctcaaagca aaactttatt     1860

aatcttattt gcggctttct gcgcaaaatt gcctgaaaga aggagatata catatggcta     1920

ccccacacat taatgcagaa atgggcgatt tcgctgacgt agttttgatg ccaggcgacc     1980

cgctgcgtgc gaagtatatt gctgaaactt tccttgaaga tgcccgtgaa gtgaacaacg     2040

ttcgcggtat gctgggcttc accggtactt acaaaggccg caaaatttcc gtaatgggtc     2100

acggtatggg tatcccgtcc tgctccatct acaccaaaga actgatcacc gatttcggcg     2160

tgaagaaaat tatccgcgtg ggttcctgtg gcgcagttct gccgcacgta aaactacgcg     2220

acgtcgttat cggtatgggt gcctgcaccg attccaaagt taaccgcatc cgttttaaag     2280

accatgactt tgccgctatc gctgactttg acatggtgcg taacgcggta gacgcggcta     2340

aagcactggg cgttgatgct cgcgtgggta acctgttctc cgctgacctg ttctactctc     2400

cggacggcga aatgttcgac gtgatggaaa aatacggcat cctcggcgtg gaaatggaag     2460

cggctggtat ctacggcgtc gctgcagaat ttggcgcgaa agccctgacc atctgcaccg     2520

tgtctgacca catccgcact cacgagcaga ccactgccgc tgagcgtcag accaccttca     2580

acgacatgat caaaatcgca ctggaatccg ttctgctggg cgataaagag taa            2633


<210> 862
<211> 1053
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fbrAroG

<400> 862
atgaattatc agaacgacga tttacgcatc aaagaaatca aagagttact tcctcctgtc       60

gcattgctgg aaaaattccc cgctactgaa aatgccgcga atacggtcgc ccatgcccga      120

aaagcgatcc ataagatcct gaaaggtaat gatgatcgcc tgttggtggt gattggccca      180

tgctcaattc atgatcctgt cgcggctaaa gagtatgcca ctcgcttgct gacgctgcgt      240

gaagagctgc aagatgagct ggaaatcgtg atgcgcgtct attttgaaaa gccgcgtact      300

acggtgggct ggaaagggct gattaacgat ccgcatatgg ataacagctt ccagatcaac      360

gacggtctgc gtattgcccg caaattgctg ctcgatatta acgacagcgg tctgccagcg      420

gcgggtgaat tcctggatat gatcacccta caatatctcg ctgacctgat gagctggggc      480

gcaattggcg cacgtaccac cgaatcgcag gtgcaccgcg aactggcgtc tggtctttct      540

tgtccggtag gtttcaaaaa tggcactgat ggtacgatta aagtggctat cgatgccatt      600

aatgccgccg gtgcgccgca ctgcttcctg tccgtaacga aatgggggca ttcggcgatt      660

gtgaatacca gcggtaacgg cgattgccat atcattctgc gcggcggtaa agagcctaac      720

tacagcgcga agcacgttgc tgaagtgaaa gaagggctga acaaagcagg cctgccagcg      780

caggtgatga tcgatttcag ccatgctaac tcgtcaaaac aattcaaaaa gcagatggat      840

gtttgtactg acgtttgcca gcagattgcc ggtggcgaaa aggccattat tggcgtgatg      900

gtggaaagcc atctggtgga aggcaatcag agcctcgaga gcggggaacc gctggcctac      960

ggtaagagca tcaccgatgc ctgcattggc tgggatgata ccgatgctct gttacgtcaa     1020

ctggcgagtg cagtaaaagc gcgtcgcggg taa                                  1053


<210> 863
<211> 2351
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fbrAroG-serA

<400> 863
ctctagaaat aattttgttt aactttaaga aggagatata catatgaatt atcagaacga       60

cgatttacgc atcaaagaaa tcaaagagtt acttcctcct gtcgcattgc tggaaaaatt      120

ccccgctact gaaaatgccg cgaatacggt cgcccatgcc cgaaaagcga tccataagat      180

cctgaaaggt aatgatgatc gcctgttggt ggtgattggc ccatgctcaa ttcatgatcc      240

tgtcgcggct aaagagtatg ccactcgctt gctgacgctg cgtgaagagc tgcaagatga      300

gctggaaatc gtgatgcgcg tctattttga aaagccgcgt actacggtgg gctggaaagg      360

gctgattaac gatccgcata tggataacag cttccagatc aacgacggtc tgcgtattgc      420

ccgcaaattg ctgctcgata ttaacgacag cggtctgcca gcggcgggtg aattcctgga      480

tatgatcacc ctacaatatc tcgctgacct gatgagctgg ggcgcaattg gcgcacgtac      540

caccgaatcg caggtgcacc gcgaactggc gtctggtctt tcttgtccgg taggtttcaa      600

aaatggcact gatggtacga ttaaagtggc tatcgatgcc attaatgccg ccggtgcgcc      660

gcactgcttc ctgtccgtaa cgaaatgggg gcattcggcg attgtgaata ccagcggtaa      720

cggcgattgc catatcattc tgcgcggcgg taaagagcct aactacagcg cgaagcacgt      780

tgctgaagtg aaagaagggc tgaacaaagc aggcctgcca gcgcaggtga tgatcgattt      840

cagccatgct aactcgtcaa aacaattcaa aaagcagatg gatgtttgta ctgacgtttg      900

ccagcagatt gccggtggcg aaaaggccat tattggcgtg atggtggaaa gccatctggt      960

ggaaggcaat cagagcctcg agagcgggga accgctggcc tacggtaaga gcatcaccga     1020

tgcctgcatt ggctgggatg ataccgatgc tctgttacgt caactggcga gtgcagtaaa     1080

agcgcgtcgc gggtaatact taagaaggag atatacatat ggcaaaggta tcgctggaga     1140

aagacaagat taagtttctg ctggtagaag gcgtgcacca aaaggcgctg gaaagccttc     1200

gtgcagctgg ttacaccaac atcgaatttc acaaaggcgc gctggatgat gaacaattaa     1260

aagaatccat ccgcgatgcc cacttcatcg gcctgcgatc ccgtacccat ctgactgaag     1320

acgtgatcaa cgccgcagaa aaactggtcg ctattggctg tttctgtatc ggaacaaatc     1380

aggttgatct ggatgcggcg gcaaagcgcg ggatcccggt atttaacgca ccgttctcaa     1440

atacgcgctc tgttgcggag ctggtgattg gcgaactgct gctgctattg cgcggcgtgc     1500

cagaagccaa tgctaaagcg catcgtggcg tgtggaacaa actggcggcg ggttcttttg     1560

aagcgcgcgg caaaaagctg ggtatcatcg gctacggtca tattggtacg caattgggca     1620

ttctggctga atcgctggga atgtatgttt acttttatga tattgaaaac aaactgccgc     1680

tgggcaacgc cactcaggta cagcatcttt ctgacctgct gaatatgagc gatgtggtga     1740

gtctgcatgt accagagaat ccgtccacca aaaatatgat gggcgcgaaa gagatttcgc     1800

taatgaagcc cggctcgctg ctgattaatg cttcgcgcgg tactgtggtg gatattccag     1860

cgctgtgtga cgcgctggcg agcaaacatc tggcgggggc ggcaatcgac gtattcccga     1920

cggaaccggc gaccaatagc gatccattta cctctccgct gtgtgaattc gacaatgtcc     1980

ttctgacgcc acacattggc ggttcgactc aggaagcgca ggagaatatc ggcttggaag     2040

ttgcgggtaa attgatcaag tattctgaca atggctcaac gctctctgcg gtgaacttcc     2100

cggaagtctc gctgccactg cacggtgggc gtcgtctgat gcacatccac gaaaaccgtc     2160

cgggcgtgct aactgcgctc aacaaaattt ttgccgagca gggcgtcaac atcgccgcgc     2220

aatatctaca aacttccgcc cagatgggtt atgtagttat tgatattgaa gccgacgaag     2280

acgttgccga aaaagcgctg caggcaatga aagctattcc gggtaccatt cgcgcccgtc     2340

tgctgtacta a                                                          2351


<210> 864
<211> 1233
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> SerA

<400> 864
atggcaaagg tatcgctgga gaaagacaag attaagtttc tgctggtaga aggcgtgcac       60

caaaaggcgc tggaaagcct tcgtgcagct ggttacacca acatcgaatt tcacaaaggc      120

gcgctggatg atgaacaatt aaaagaatcc atccgcgatg cccacttcat cggcctgcga      180

tcccgtaccc atctgactga agacgtgatc aacgccgcag aaaaactggt cgctattggc      240

tgtttctgta tcggaacaaa tcaggttgat ctggatgcgg cggcaaagcg cgggatcccg      300

gtatttaacg caccgttctc aaatacgcgc tctgttgcgg agctggtgat tggcgaactg      360

ctgctgctat tgcgcggcgt gccagaagcc aatgctaaag cgcatcgtgg cgtgtggaac      420

aaactggcgg cgggttcttt tgaagcgcgc ggcaaaaagc tgggtatcat cggctacggt      480

catattggta cgcaattggg cattctggct gaatcgctgg gaatgtatgt ttacttttat      540

gatattgaaa acaaactgcc gctgggcaac gccactcagg tacagcatct ttctgacctg      600

ctgaatatga gcgatgtggt gagtctgcat gtaccagaga atccgtccac caaaaatatg      660

atgggcgcga aagagatttc gctaatgaag cccggctcgc tgctgattaa tgcttcgcgc      720

ggtactgtgg tggatattcc agcgctgtgt gacgcgctgg cgagcaaaca tctggcgggg      780

gcggcaatcg acgtattccc gacggaaccg gcgaccaata gcgatccatt tacctctccg      840

ctgtgtgaat tcgacaatgt ccttctgacg ccacacattg gcggttcgac tcaggaagcg      900

caggagaata tcggcttgga agttgcgggt aaattgatca agtattctga caatggctca      960

acgctctctg cggtgaactt cccggaagtc tcgctgccac tgcacggtgg gcgtcgtctg     1020

atgcacatcc acgaaaaccg tccgggcgtg ctaactgcgc tcaacaaaat ttttgccgag     1080

cagggcgtca acatcgccgc gcaatatcta caaacttccg cccagatggg ttatgtagtt     1140

attgatattg aagccgacga agacgttgcc gaaaaagcgc tgcaggcaat gaaagctatt     1200

ccgggtacca ttcgcgcccg tctgctgtac taa                                  1233


<210> 865
<211> 1424
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-kynU(Pseudomonas)

<400> 865
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaattat ataaaagtgg gaggtgcccg      120

aatgacgacc cgaaatgatt gcctagcgtt ggatgcacag gacagtctgg ctccgctgcg      180

ccaacaattt gcgctgccgg agggtgtgat atacctggat ggcaattcgc tgggcgcacg      240

tccggtagct gcgctggctc gcgcgcaggc tgtgatcgca gaagaatggg gcaacgggtt      300

gatccgttca tggaactctg cgggctggcg tgatctgtct gaacgcctgg gtaatcgcct      360

ggctaccctg attggtgcgc gcgatgggga agtagttgtt actgatacca cctcgattaa      420

tctgtttaaa gtgctgtcag cggcgctgcg cgtgcaagct acccgtagcc cggagcgccg      480

tgttatcgtg actgagacct cgaatttccc gaccgacctg tatattgcgg aagggttggc      540

ggatatgctg caacaaggtt acactctgcg tttggtggat tcaccggaag agctgccaca      600

ggctatagat caggacaccg cggtggtgat gctgacgcac gtaaattata aaaccggtta      660

tatgcacgac atgcaggctc tgaccgcgtt gagccacgag tgtggggctc tggcgatttg      720

ggatctggcg cactctgctg gcgctgtgcc ggtggacctg caccaagcgg gcgcggacta      780

tgcgattggc tgcacgtaca aatacctgaa tggcggcccg ggttcgcaag cgtttgtttg      840

ggtttcgccg caactgtgcg acctggtacc gcagccgctg tctggttggt tcggccatag      900

tcgccaattc gcgatggagc cgcgctacga accttctaac ggcattgctc gctatctgtg      960

cggcactcag cctattacta gcttggctat ggtggagtgc ggcctggatg tgtttgcgca     1020

gacggatatg gcttcgctgc gccgtaaaag tctggcgctg actgatctgt tcatcgagct     1080

ggttgaacaa cgctgcgctg cacacgaact gaccctggtt actccacgtg aacacgcgaa     1140

acgcggctct cacgtgtctt ttgaacaccc cgagggttac gctgttattc aagctctgat     1200

tgatcgtggc gtgatcggcg attaccgtga gccacgtatt atgcgtttcg gtttcactcc     1260

tctgtatact acttttacgg aagtttggga tgcagtacaa atcctgggcg aaatcctgga     1320

tcgtaagact tgggcgcagg ctcagtttca ggtgcgccac tctgttactt aaaaataaaa     1380

cgaaaggctc agtcgaaaga ctgggccttt cgttttatct gttg                      1424


<210> 866
<211> 1571
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-kynU(Human)

<400> 866
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaatatc aagacacgag gaggtaagat      120

tatggagcct tcatctttag aactgccagc ggacacggtg cagcgcatcg cggcggaact      180

gaagtgccat ccgactgatg agcgtgtggc gctgcatctg gacgaagaag ataaactgcg      240

ccactttcgt gaatgttttt atattcctaa aattcaagac ttgccgccgg tagatttgag      300

tctcgttaac aaagatgaaa acgcgatcta ctttctgggc aactctctgg gtctgcaacc      360

aaaaatggtt aaaacgtacc tggaggaaga actggataaa tgggcaaaaa tcgcggctta      420

tggtcacgaa gtgggcaagc gtccttggat tactggcgac gagtctattg tgggtttgat      480

gaaagatatt gtgggcgcga atgaaaagga aattgcactg atgaatgctc tgaccgttaa      540

tctgcacctg ctgatgctgt ctttttttaa accgaccccg aaacgctaca aaatactgct      600

ggaagcgaaa gcgtttccgt cggatcacta tgctatagaa agtcaactgc agttgcatgg      660

tctgaatatc gaggaatcta tgcgcatgat taaaccgcgt gagggtgaag aaacgctgcg      720

tattgaagac attctggaag ttattgaaaa agaaggtgat tctatcgcag ttatactgtt      780

ttctggcgtg cacttttata caggtcagca cttcaatatc ccggcaatca ctaaagcggg      840

gcaggcaaaa ggctgctatg ttggttttga cctggcgcat gcagtgggga atgttgaact      900

gtatctgcac gattggggcg ttgatttcgc gtgttggtgt agctacaaat atctgaacgc      960

tggcgcgggt ggcattgctg gcgcttttat tcacgaaaaa cacgcgcaca ccattaaacc     1020

ggctctggtt ggctggttcg gtcatgagct gagtactcgc tttaaaatgg ataacaaact     1080

gcaattgatt ccgggtgttt gcggcttccg tatcagcaat ccgccgattc tgctggtttg     1140

cagcctgcac gctagtctgg aaatctttaa gcaggcgact atgaaagcgc tgcgcaaaaa     1200

atctgtgctg ctgaccggct atctggagta tctgatcaaa cacaattatg gcaaagataa     1260

agctgcaact aaaaaaccgg tagtgaacat tatcaccccc tcacacgtgg aggagcgcgg     1320

ttgtcagctg actattactt tcagtgtacc taataaagat gtgttccagg aactggaaaa     1380

acgcggcgtt gtttgtgata aacgtaaccc gaatggtatt cgcgtggctc ctgtgccgct     1440

gtacaattca ttccacgatg tttataaatt caccaacctg ctgacttcta ttctcgacag     1500

tgctgagact aaaaattaaa aataaaacga aaggctcagt cgaaagactg ggcctttcgt     1560

tttatctgtt g                                                          1571


<210> 867
<211> 1310
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> ptet-kynU(Shewanella)

<400> 867
atctaatcta gacatcatta attcctaatt tttgttgaca ctctatcatt gatagagtta       60

ttttaccact ccctatcagt gatagagaaa agtgaatggt tcaccaccac aaggagggat      120

tatgctgctg aatgtaaaac aggacttttg cctggcaggc ccgggctacc tgctgaatca      180

ctcggttggc cgtccgctga aatcaactga gcaagcgctg aaacaagcat tttttgctcc      240

gtggcaagag agcggtcgtg aaccgtgggg ccagtggctg ggtgttattg ataatttcac      300

tgctgcgctg gcatctctgt ttaatggtca accgcaggat ttttgtccgc aggttaacct      360

gagcagcgcg ctgactaaaa ttgtgatgtc actggatcgt ctgactcgcg atctgacccg      420

caatggcggt gctgttgtgc tgatgtctga aatcgatttc ccatctatgg gcttcgcgtt      480

gaaaaaagcg ctgccagcga gctgcgaact gcgttttatc ccgaaaagtc tggacgtgac      540

tgatccgaac gtatgggatg cacacatctg tgatgatgta gacctggttt ttgtgtctca      600

cgcctatagt aatacgggcc aacaggctcc gctggcgcaa atcatctctc tggcgcgtga      660

acgtggctgc ctgtcactgg tggatgtagc gcaatcagcg gggattttgc cgctggatct      720

ggcgaaactg caaccggact tcatgatcgg cagttcggtt aaatggctgt gctcgggccc      780

tggtgcggca tatctgtggg ttaatccggc gattctgccg gaatgtcagc cgcaggatgt      840

gggctggttt tcacatgaga atccctttga attcgacatc cacgatttcc gctaccaccc      900

gactgcactg cgcttttggg gtggtacgcc gtcgatcgcg ccttatgcga tcgcggcgca      960

ctcgatcgaa tattttgcca atatcggctc gcaagtgatg cgtgaacaca acctgcaact     1020

gatggaaccg gtggttcagg cgctggacaa tgaactggtg agcccgcagg aagtggataa     1080

acgctcaggc actattattc tgcaattcgg tgaacgtcaa ccgcaaattc tggcggctct     1140

ggctgcggcg aacatttcgg tggacactcg ttctttgggg attcgtgtta gtccgcacat     1200

ttataatgat gaggcggaca ttgcgcgcct gctgggtgtg atcaaagcaa atcgctaaaa     1260

ataaaacgaa aggctcagtc gaaagactgg gcctttcgtt ttatctgttg                1310


<210> 868
<211> 1096
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fbrAroG

<400> 868
ctctagaaat aattttgttt aactttaaga aggagatata catatgaatt atcagaacga       60

cgatttacgc atcaaagaaa tcaaagagtt acttcctcct gtcgcattgc tggaaaaatt      120

ccccgctact gaaaatgccg cgaatacggt cgcccatgcc cgaaaagcga tccataagat      180

cctgaaaggt aatgatgatc gcctgttggt ggtgattggc ccatgctcaa ttcatgatcc      240

tgtcgcggct aaagagtatg ccactcgctt gctgacgctg cgtgaagagc tgcaagatga      300

gctggaaatc gtgatgcgcg tctattttga aaagccgcgt actacggtgg gctggaaagg      360

gctgattaac gatccgcata tggataacag cttccagatc aacgacggtc tgcgtattgc      420

ccgcaaattg ctgctcgata ttaacgacag cggtctgcca gcggcgggtg aattcctgga      480

tatgatcacc ctacaatatc tcgctgacct gatgagctgg ggcgcaattg gcgcacgtac      540

caccgaatcg caggtgcacc gcgaactggc gtctggtctt tcttgtccgg taggtttcaa      600

aaatggcact gatggtacga ttaaagtggc tatcgatgcc attaatgccg ccggtgcgcc      660

gcactgcttc ctgtccgtaa cgaaatgggg gcattcggcg attgtgaata ccagcggtaa      720

cggcgattgc catatcattc tgcgcggcgg taaagagcct aactacagcg cgaagcacgt      780

tgctgaagtg aaagaagggc tgaacaaagc aggcctgcca gcgcaggtga tgatcgattt      840

cagccatgct aactcgtcaa aacaattcaa aaagcagatg gatgtttgta ctgacgtttg      900

ccagcagatt gccggtggcg aaaaggccat tattggcgtg atggtggaaa gccatctggt      960

ggaaggcaat cagagcctcg agagcgggga accgctggcc tacggtaaga gcatcaccga     1020

tgcctgcatt ggctgggatg ataccgatgc tctgttacgt caactggcga gtgcagtaaa     1080

agcgcgtcgc gggtaa                                                     1096


<210> 869
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61133

<400> 869
tctagagaaa gacccgagac actagatg                                          28


<210> 870
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61134

<400> 870
tctagagaaa gaccggaaat actagatg                                          28


<210> 871
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61135

<400> 871
tctagagaaa gaccggagac actagatg                                          28


<210> 872
<211> 6573
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> TrpEDCBA

<400> 872
ctctagaaat aattttgttt aactttaaga aggagatata catatgcaaa cacaaaaacc       60

gactctcgaa ctgctaacct gcgaaggcgc ttatcgcgac aacccgactg cgctttttca      120

ccagttgtgt ggggatcgtc cggcaacgct gctgctggaa tccgcagata tcgacagcaa      180

agatgattta aaaagcctgc tgctggtaga cagtgcgctg cgcattacag cattaagtga      240

cactgtcaca atccaggcgc tttccggcaa tggagaagcc ctgttgacac tactggataa      300

cgccttgcct gcgggtgtgg aaaatgaaca atcaccaaac tgccgcgtac tgcgcttccc      360

gcctgtcagt ccactgctgg atgaagacgc ccgcttatgc tccctttcgg tttttgacgc      420

tttccgctta ttacagaatc tgttgaatgt accgaaggaa gaacgagaag caatgttctt      480

cggcggcctg ttctcttatg accttgtggc gggatttgaa aatttaccgc aactgtcagc      540

ggaaaatagc tgccctgatt tctgttttta tctcgctgaa acgctgatgg tgattgacca      600

tcagaaaaaa agcactcgta ttcaggccag cctgtttgct ccgaatgaag aagaaaaaca      660

acgtctcact gctcgcctga acgaactacg tcagcaactg accgaagccg cgccgccgct      720

gccggtggtt tccgtgccgc atatgcgttg tgaatgtaac cagagcgatg aagagttcgg      780

tggtgtagtg cgtttgttgc aaaaagcgat tcgcgccgga gaaattttcc aggtggtgcc      840

atctcgccgt ttctctctgc cctgcccgtc accgctggca gcctattacg tgctgaaaaa      900

gagtaatccc agcccgtaca tgttttttat gcaggataat gatttcaccc tgtttggcgc      960

gtcgccggaa agttcgctca agtatgacgc caccagccgc cagattgaga tttacccgat     1020

tgccggaaca cgtccacgcg gtcgtcgtgc cgatggttcg ctggacagag acctcgacag     1080

ccgcatcgaa ctggagatgc gtaccgatca taaagagctt tctgaacatc tgatgctggt     1140

ggatctcgcc cgtaatgacc tggcacgcat ttgcacaccc ggcagccgct acgtcgccga     1200

tctcaccaaa gttgaccgtt actcttacgt gatgcaccta gtctcccgcg ttgttggtga     1260

gctgcgccac gatctcgacg ccctgcacgc ttaccgcgcc tgtatgaata tggggacgtt     1320

aagcggtgca ccgaaagtac gcgctatgca gttaattgcc gaagcagaag gtcgtcgacg     1380

cggcagctac ggcggcgcgg taggttattt taccgcgcat ggcgatctcg acacctgcat     1440

tgtgatccgc tcggcgctgg tggaaaacgg tatcgccacc gtgcaagccg gtgctggcgt     1500

agtccttgat tctgttccgc agtcggaagc cgacgaaact cgtaataaag cccgcgctgt     1560

actgcgcgct attgccaccg cgcatcatgc acaggagacg ttctaatggc tgacattctg     1620

ctgctcgata atatcgactc ttttacgtac aacctggcag atcagttgcg cagcaatggt     1680

cataacgtgg tgatttaccg caaccatatt ccggcgcaga ccttaattga acgcctggcg     1740

acgatgagca atccggtgct gatgctttct cctggccccg gtgtgccgag cgaagccggt     1800

tgtatgccgg aactcctcac ccgcttgcgt ggcaagctgc caattattgg catttgcctc     1860

ggacatcagg cgattgtcga agcttacggg ggctatgtcg gtcaggcggg cgaaattctt     1920

cacggtaaag cgtcgagcat tgaacatgac ggtcaggcga tgtttgccgg attaacaaac     1980

ccgctgccag tggcgcgtta tcactcgctg gttggcagta acattccggc cggtttaacc     2040

atcaacgccc attttaatgg catggtgatg gcggtgcgtc acgatgcaga tcgcgtttgt     2100

ggattccagt tccatccgga atccattctt actacccagg gcgctcgcct gctggaacaa     2160

acgctggcct gggcgcagca gaaactagag ccaaccaaca cgctgcaacc gattctggaa     2220

aaactgtatc aggcacagac gcttagccaa caagaaagcc accagctgtt ttcagcggtg     2280

gtacgtggcg agctgaagcc ggaacaactg gcggcggcgc tggtgagcat gaaaattcgc     2340

ggtgaacacc cgaacgagat cgccggggca gcaaccgcgc tactggaaaa cgccgcgcca     2400

ttcccgcgcc cggattatct gtttgccgat atcgtcggta ctggcggtga cggcagcaac     2460

agcatcaata tttctaccgc cagtgcgttt gtcgccgcgg cctgcgggct gaaagtggcg     2520

aaacacggca accgtagcgt ctccagtaaa tccggctcgt cggatctgct ggcggcgttc     2580

ggtattaatc ttgatatgaa cgccgataaa tcgcgccagg cgctggatga gttaggcgtc     2640

tgtttcctct ttgcgccgaa gtatcacacc ggattccgcc atgcgatgcc ggttcgccag     2700

caactgaaaa cccgcactct gttcaacgtg ctgggaccat tgattaaccc ggcgcatccg     2760

ccgctggcgc taattggtgt ttatagtccg gaactggtgc tgccgattgc cgaaaccttg     2820

cgcgtgctgg ggtatcaacg cgcggcagtg gtgcacagcg gcgggatgga tgaagtttca     2880

ttacacgcgc cgacaatcgt tgccgaacta catgacggcg aaattaagag ctatcaattg     2940

accgctgaag attttggcct gacaccctac caccaggagc aattggcagg cggaacaccg     3000

gaagaaaacc gtgacatttt aacacgcttg ttacaaggta aaggcgacgc cgcccatgaa     3060

gcagccgtcg cggcgaatgt cgccatgtta atgcgcctgc atggccatga agatctgcaa     3120

gccaatgcgc aaaccgttct tgaggtactg cgcagtggtt ccgcttacga cagagtcacc     3180

gcactggcgg cacgagggta aatgatgcaa accgttttag cgaaaatcgt cgcagacaag     3240

gcgatttggg tagaaacccg caaagagcag caaccgctgg ccagttttca gaatgaggtt     3300

cagccgagca cgcgacattt ttatgatgca cttcagggcg cacgcacggc gtttattctg     3360

gagtgtaaaa aagcgtcgcc gtcaaaaggc gtgatccgtg atgatttcga tccggcacgc     3420

attgccgcca tttataaaca ttacgcttcg gcaatttcag tgctgactga tgagaaatat     3480

tttcagggga gctttgattt cctccccatc gtcagccaaa tcgccccgca gccgatttta     3540

tgtaaagact tcattatcga tccttaccag atctatctgg cgcgctatta ccaggccgat     3600

gcctgcttat taatgctttc agtactggat gacgaacaat atcgccagct tgcagccgtc     3660

gcccacagtc tggagatggg tgtgctgacc gaagtcagta atgaagagga actggagcgc     3720

gccattgcat tgggggcaaa ggtcgttggc atcaacaacc gcgatctgcg cgatttgtcg     3780

attgatctca accgtacccg cgagcttgcg ccgaaactgg ggcacaacgt gacggtaatc     3840

agcgaatccg gcatcaatac ttacgctcag gtgcgcgagt taagccactt cgctaacggc     3900

tttctgattg gttcggcgtt gatggcccat gacgatttga acgccgccgt gcgtcgggtg     3960

ttgctgggtg agaataaagt atgtggcctg acacgtgggc aagatgctaa agcagcttat     4020

gacgcgggcg cgatttacgg tgggttgatt tttgttgcga catcaccgcg ttgcgtcaac     4080

gttgaacagg cgcaggaagt gatggctgca gcaccgttgc agtatgttgg cgtgttccgc     4140

aatcacgata ttgccgatgt ggcggacaaa gctaaggtgt tatcgctggc ggcagtgcaa     4200

ctgcatggta atgaagatca gctgtatatc gacaatctgc gtgaggctct gccagcacac     4260

gtcgccatct ggaaggcttt aagtgtcggt gaaactcttc ccgcgcgcga ttttcagcac     4320

atcgataaat atgtattcga caacggtcag ggcgggagcg gacaacgttt cgactggtca     4380

ctattaaatg gtcaatcgct tggcaacgtt ctgctggcgg ggggcttagg cgcagataac     4440

tgcgtggaag cggcacaaac cggctgcgcc gggcttgatt ttaattctgc tgtagagtcg     4500

caaccgggta tcaaagacgc acgtcttttg gcctcggttt tccagacgct gcgcgcatat     4560

taaggaaagg aacaatgaca acattactta acccctattt tggtgagttt ggcggcatgt     4620

acgtgccaca aatcctgatg cctgctctgc gccagctgga agaagctttt gtcagcgcgc     4680

aaaaagatcc tgaatttcag gctcagttca acgacctgct gaaaaactat gccgggcgtc     4740

caaccgcgct gaccaaatgc cagaacatta cagccgggac gaacaccacg ctgtatctga     4800

agcgcgaaga tttgctgcac ggcggcgcgc ataaaactaa ccaggtgctc ggtcaggctt     4860

tactggcgaa gcggatgggt aaaactgaaa ttattgccga aaccggtgcc ggtcagcatg     4920

gcgtggcgtc ggcccttgcc agcgccctgc tcggcctgaa atgccgaatt tatatgggtg     4980

ccaaagacgt tgaacgccag tcgcccaacg ttttccggat gcgcttaatg ggtgcggaag     5040

tgatcccggt acatagcggt tccgcgaccc tgaaagatgc ctgtaatgag gcgctacgcg     5100

actggtccgg cagttatgaa accgcgcact atatgctggg taccgcagct ggcccgcatc     5160

cttacccgac cattgtgcgt gagtttcagc ggatgattgg cgaagaaacg aaagcgcaga     5220

ttctggaaag agaaggtcgc ctgccggatg ccgttatcgc ctgtgttggc ggtggttcga     5280

atgccatcgg tatgtttgca gatttcatca acgaaaccga cgtcggcctg attggtgtgg     5340

agcctggcgg ccacggtatc gaaactggcg agcacggcgc accgttaaaa catggtcgcg     5400

tgggcatcta tttcggtatg aaagcgccga tgatgcaaac cgaagacggg caaattgaag     5460

agtcttactc catttctgcc gggctggatt tcccgtccgt cggcccgcaa catgcgtatc     5520

tcaacagcac tggacgcgct gattacgtgt ctattaccga cgatgaagcc ctggaagcct     5580

ttaaaacgct ttgcctgcat gaagggatca tcccggcgct ggaatcctcc cacgccctgg     5640

cccatgcgct gaaaatgatg cgcgaaaatc cggaaaaaga gcagctactg gtggttaacc     5700

tttccggtcg cggcgataaa gacatcttca ccgttcacga tattttgaaa gcacgagggg     5760

aaatctgatg gaacgctacg aatctctgtt tgcccagttg aaggagcgca aagaaggcgc     5820

attcgttcct ttcgtcaccc tcggtgatcc gggcattgag cagtcgttga aaattatcga     5880

tacgctaatt gaagccggtg ctgacgcgct ggagttaggc atccccttct ccgacccact     5940

ggcggatggc ccgacgattc aaaacgccac actgcgtgct tttgcggcgg gagtaacccc     6000

ggcgcagtgc tttgagatgc tggcactcat tcgccagaag cacccgacca ttcccatcgg     6060

ccttttgatg tatgccaacc tggtgtttaa caaaggcatt gatgagtttt atgccgagtg     6120

cgagaaagtc ggcgtcgatt cggtgctggt tgccgatgtg cccgtggaag agtccgcgcc     6180

cttccgccag gccgcgttgc gtcataatgt cgcacctatc tttatttgcc cgccgaatgc     6240

cgacgatgat ttgctgcgcc agatagcctc ttacggtcgt ggttacacct atttgctgtc     6300

gcgagcgggc gtgaccggcg cagaaaaccg cgccgcgtta cccctcaatc atctggttgc     6360

gaagctgaaa gagtacaacg ctgcgcctcc attgcaggga tttggtattt ccgccccgga     6420

tcaggtaaaa gccgcgattg atgcaggagc tgcgggcgcg atttctggtt cggccatcgt     6480

taaaatcatc gagcaacata ttaatgagcc agagaaaatg ctggcggcac tgaaagcttt     6540

tgtacaaccg atgaaagcgg cgacgcgcag tta                                  6573


<210> 873
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61132

<400> 873
tctagagaaa gacaggatta actagatg                                          28


<210> 874
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61136

<400> 874
tctagagaaa gagctgagca actagatg                                          28


<210> 875
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61137

<400> 875
tctagagaaa gagtagatca actagatg                                          28


<210> 876
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61138

<400> 876
tctagagaaa gatatgaata actagatg                                          28


<210> 877
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61139

<400> 877
tctagagaaa gattagagtc actagatg                                          28


<210> 878
<211> 6574
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fbrS40FTrpE-DCBA

<400> 878
ctctagaaat aattttgttt aactttaaga aggagatata catatgcaaa cacaaaaacc       60

gactctcgaa ctgctaacct gcgaaggcgc ttatcgcgac aacccgactg cgctttttca      120

ccagttgtgt ggggatcgtc cggcaacgct gctgctggaa ttcgcagata tcgacagcaa      180

agatgattta aaaagcctgc tgctggtaga cagtgcgctg cgcattacag cattaagtga      240

cactgtcaca atccaggcgc tttccggcaa tggagaagcc ctgttgacac tactggataa      300

cgccttgcct gcgggtgtgg aaaatgaaca atcaccaaac tgccgcgtac tgcgcttccc      360

gcctgtcagt ccactgctgg atgaagacgc ccgcttatgc tccctttcgg tttttgacgc      420

tttccgctta ttacagaatc tgttgaatgt accgaaggaa gaacgagaag caatgttctt      480

cggcggcctg ttctcttatg accttgtggc gggatttgaa aatttaccgc aactgtcagc      540

ggaaaatagc tgccctgatt tctgttttta tctcgctgaa acgctgatgg tgattgacca      600

tcagaaaaaa agcactcgta ttcaggccag cctgtttgct ccgaatgaag aagaaaaaca      660

acgtctcact gctcgcctga acgaactacg tcagcaactg accgaagccg cgccgccgct      720

gccggtggtt tccgtgccgc atatgcgttg tgaatgtaac cagagcgatg aagagttcgg      780

tggtgtagtg cgtttgttgc aaaaagcgat tcgcgccgga gaaattttcc aggtggtgcc      840

atctcgccgt ttctctctgc cctgcccgtc accgctggca gcctattacg tgctgaaaaa      900

gagtaatccc agcccgtaca tgttttttat gcaggataat gatttcaccc tgtttggcgc      960

gtcgccggaa agttcgctca agtatgacgc caccagccgc cagattgaga tttacccgat     1020

tgccggaaca cgtccacgcg gtcgtcgtgc cgatggttcg ctggacagag acctcgacag     1080

ccgcatcgaa ctggagatgc gtaccgatca taaagagctt tctgaacatc tgatgctggt     1140

ggatctcgcc cgtaatgacc tggcacgcat ttgcacaccc ggcagccgct acgtcgccga     1200

tctcaccaaa gttgaccgtt actcttacgt gatgcaccta gtctcccgcg ttgttggtga     1260

gctgcgccac gatctcgacg ccctgcacgc ttaccgcgcc tgtatgaata tggggacgtt     1320

aagcggtgca ccgaaagtac gcgctatgca gttaattgcc gaagcagaag gtcgtcgacg     1380

cggcagctac ggcggcgcgg taggttattt taccgcgcat ggcgatctcg acacctgcat     1440

tgtgatccgc tcggcgctgg tggaaaacgg tatcgccacc gtgcaagccg gtgctggcgt     1500

agtccttgat tctgttccgc agtcggaagc cgacgaaact cgtaataaag cccgcgctgt     1560

actgcgcgct attgccaccg cgcatcatgc acaggagacg ttctaatggc tgacattctg     1620

ctgctcgata atatcgactc ttttacgtac aacctggcag atcagttgcg cagcaatggt     1680

cataacgtgg tgatttaccg caaccatatt ccggcgcaga ccttaattga acgcctggcg     1740

acgatgagca atccggtgct gatgctttct cctggccccg gtgtgccgag cgaagccggt     1800

tgtatgccgg aactcctcac ccgcttgcgt ggcaagctgc caattattgg catttgcctc     1860

ggacatcagg cgattgtcga agcttacggg ggctatgtcg gtcaggcggg cgaaattctt     1920

cacggtaaag cgtcgagcat tgaacatgac ggtcaggcga tgtttgccgg attaacaaac     1980

ccgctgccag tggcgcgtta tcactcgctg gttggcagta acattccggc cggtttaacc     2040

atcaacgccc attttaatgg catggtgatg gcggtgcgtc acgatgcaga tcgcgtttgt     2100

ggattccagt tccatccgga atccattctt actacccagg gcgctcgcct gctggaacaa     2160

acgctggcct gggcgcagca gaaactagag ccaaccaaca cgctgcaacc gattctggaa     2220

aaactgtatc aggcacagac gcttagccaa caagaaagcc accagctgtt ttcagcggtg     2280

gtacgtggcg agctgaagcc ggaacaactg gcggcggcgc tggtgagcat gaaaattcgc     2340

ggtgaacacc cgaacgagat cgccggggca gcaaccgcgc tactggaaaa cgccgcgcca     2400

ttcccgcgcc cggattatct gtttgccgat atcgtcggta ctggcggtga cggcagcaac     2460

agcatcaata tttctaccgc cagtgcgttt gtcgccgcgg cctgcgggct gaaagtggcg     2520

aaacacggca accgtagcgt ctccagtaaa tccggctcgt cggatctgct ggcggcgttc     2580

ggtattaatc ttgatatgaa cgccgataaa tcgcgccagg cgctggatga gttaggcgtc     2640

tgtttcctct ttgcgccgaa gtatcacacc ggattccgcc atgcgatgcc ggttcgccag     2700

caactgaaaa cccgcactct gttcaacgtg ctgggaccat tgattaaccc ggcgcatccg     2760

ccgctggcgc taattggtgt ttatagtccg gaactggtgc tgccgattgc cgaaaccttg     2820

cgcgtgctgg ggtatcaacg cgcggcagtg gtgcacagcg gcgggatgga tgaagtttca     2880

ttacacgcgc cgacaatcgt tgccgaacta catgacggcg aaattaagag ctatcaattg     2940

accgctgaag attttggcct gacaccctac caccaggagc aattggcagg cggaacaccg     3000

gaagaaaacc gtgacatttt aacacgcttg ttacaaggta aaggcgacgc cgcccatgaa     3060

gcagccgtcg cggcgaatgt cgccatgtta atgcgcctgc atggccatga agatctgcaa     3120

gccaatgcgc aaaccgttct tgaggtactg cgcagtggtt ccgcttacga cagagtcacc     3180

gcactggcgg cacgagggta aatgatgcaa accgttttag cgaaaatcgt cgcagacaag     3240

gcgatttggg tagaaacccg caaagagcag caaccgctgg ccagttttca gaatgaggtt     3300

cagccgagca cgcgacattt ttatgatgca cttcagggcg cacgcacggc gtttattctg     3360

gagtgtaaaa aagcgtcgcc gtcaaaaggc gtgatccgtg atgatttcga tccggcacgc     3420

attgccgcca tttataaaca ttacgcttcg gcaatttcag tgctgactga tgagaaatat     3480

tttcagggga gctttgattt cctccccatc gtcagccaaa tcgccccgca gccgatttta     3540

tgtaaagact tcattatcga tccttaccag atctatctgg cgcgctatta ccaggccgat     3600

gcctgcttat taatgctttc agtactggat gacgaacaat atcgccagct tgcagccgtc     3660

gcccacagtc tggagatggg tgtgctgacc gaagtcagta atgaagagga actggagcgc     3720

gccattgcat tgggggcaaa ggtcgttggc atcaacaacc gcgatctgcg cgatttgtcg     3780

attgatctca accgtacccg cgagcttgcg ccgaaactgg ggcacaacgt gacggtaatc     3840

agcgaatccg gcatcaatac ttacgctcag gtgcgcgagt taagccactt cgctaacggc     3900

tttctgattg gttcggcgtt gatggcccat gacgatttga acgccgccgt gcgtcgggtg     3960

ttgctgggtg agaataaagt atgtggcctg acacgtgggc aagatgctaa agcagcttat     4020

gacgcgggcg cgatttacgg tgggttgatt tttgttgcga catcaccgcg ttgcgtcaac     4080

gttgaacagg cgcaggaagt gatggctgca gcaccgttgc agtatgttgg cgtgttccgc     4140

aatcacgata ttgccgatgt ggcggacaaa gctaaggtgt tatcgctggc ggcagtgcaa     4200

ctgcatggta atgaagatca gctgtatatc gacaatctgc gtgaggctct gccagcacac     4260

gtcgccatct ggaaggcttt aagtgtcggt gaaactcttc ccgcgcgcga ttttcagcac     4320

atcgataaat atgtattcga caacggtcag ggcgggagcg gacaacgttt cgactggtca     4380

ctattaaatg gtcaatcgct tggcaacgtt ctgctggcgg ggggcttagg cgcagataac     4440

tgcgtggaag cggcacaaac cggctgcgcc gggcttgatt ttaattctgc tgtagagtcg     4500

caaccgggta tcaaagacgc acgtcttttg gcctcggttt tccagacgct gcgcgcatat     4560

taaggaaagg aacaatgaca acattactta acccctattt tggtgagttt ggcggcatgt     4620

acgtgccaca aatcctgatg cctgctctgc gccagctgga agaagctttt gtcagcgcgc     4680

aaaaagatcc tgaatttcag gctcagttca acgacctgct gaaaaactat gccgggcgtc     4740

caaccgcgct gaccaaatgc cagaacatta cagccgggac gaacaccacg ctgtatctga     4800

agcgcgaaga tttgctgcac ggcggcgcgc ataaaactaa ccaggtgctc ggtcaggctt     4860

tactggcgaa gcggatgggt aaaactgaaa ttattgccga aaccggtgcc ggtcagcatg     4920

gcgtggcgtc ggcccttgcc agcgccctgc tcggcctgaa atgccgaatt tatatgggtg     4980

ccaaagacgt tgaacgccag tcgcccaacg ttttccggat gcgcttaatg ggtgcggaag     5040

tgatcccggt acatagcggt tccgcgaccc tgaaagatgc ctgtaatgag gcgctacgcg     5100

actggtccgg cagttatgaa accgcgcact atatgctggg taccgcagct ggcccgcatc     5160

cttacccgac cattgtgcgt gagtttcagc ggatgattgg cgaagaaacg aaagcgcaga     5220

ttctggaaag agaaggtcgc ctgccggatg ccgttatcgc ctgtgttggc ggtggttcga     5280

atgccatcgg tatgtttgca gatttcatca acgaaaccga cgtcggcctg attggtgtgg     5340

agcctggcgg ccacggtatc gaaactggcg agcacggcgc accgttaaaa catggtcgcg     5400

tgggcatcta tttcggtatg aaagcgccga tgatgcaaac cgaagacggg caaattgaag     5460

agtcttactc catttctgcc gggctggatt tcccgtccgt cggcccgcaa catgcgtatc     5520

tcaacagcac tggacgcgct gattacgtgt ctattaccga cgatgaagcc ctggaagcct     5580

ttaaaacgct ttgcctgcat gaagggatca tcccggcgct ggaatcctcc cacgccctgg     5640

cccatgcgct gaaaatgatg cgcgaaaatc cggaaaaaga gcagctactg gtggttaacc     5700

tttccggtcg cggcgataaa gacatcttca ccgttcacga tattttgaaa gcacgagggg     5760

aaatctgatg gaacgctacg aatctctgtt tgcccagttg aaggagcgca aagaaggcgc     5820

attcgttcct ttcgtcaccc tcggtgatcc gggcattgag cagtcgttga aaattatcga     5880

tacgctaatt gaagccggtg ctgacgcgct ggagttaggc atccccttct ccgacccact     5940

ggcggatggc ccgacgattc aaaacgccac actgcgtgct tttgcggcgg gagtaacccc     6000

ggcgcagtgc tttgagatgc tggcactcat tcgccagaag cacccgacca ttcccatcgg     6060

ccttttgatg tatgccaacc tggtgtttaa caaaggcatt gatgagtttt atgccgagtg     6120

cgagaaagtc ggcgtcgatt cggtgctggt tgccgatgtg cccgtggaag agtccgcgcc     6180

cttccgccag gccgcgttgc gtcataatgt cgcacctatc tttatttgcc cgccgaatgc     6240

cgacgatgat ttgctgcgcc agatagcctc ttacggtcgt ggttacacct atttgctgtc     6300

gcgagcgggc gtgaccggcg cagaaaaccg cgccgcgtta cccctcaatc atctggttgc     6360

gaagctgaaa gagtacaacg ctgcgcctcc attgcaggga tttggtattt ccgccccgga     6420

tcaggtaaaa gccgcgattg atgcaggagc tgcgggcgcg atttctggtt cggccatcgt     6480

taaaatcatc gagcaacata ttaatgagcc agagaaaatg ctggcggcac tgaaagcttt     6540

tgtacaaccg atgaaagcgg cgacgcgcag ttaa                                 6574


<210> 879
<211> 1562
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fbrTrpE

<400> 879
atgcaaacac aaaaaccgac tctcgaactg ctaacctgcg aaggcgctta tcgcgacaac       60

ccgactgcgc tttttcacca gttgtgtggg gatcgtccgg caacgctgct gctggaattc      120

gcagatatcg acagcaaaga tgatttaaaa agcctgctgc tggtagacag tgcgctgcgc      180

attacagcat taagtgacac tgtcacaatc caggcgcttt ccggcaatgg agaagccctg      240

ttgacactac tggataacgc cttgcctgcg ggtgtggaaa atgaacaatc accaaactgc      300

cgcgtactgc gcttcccgcc tgtcagtcca ctgctggatg aagacgcccg cttatgctcc      360

ctttcggttt ttgacgcttt ccgcttatta cagaatctgt tgaatgtacc gaaggaagaa      420

cgagaagcaa tgttcttcgg cggcctgttc tcttatgacc ttgtggcggg atttgaaaat      480

ttaccgcaac tgtcagcgga aaatagctgc cctgatttct gtttttatct cgctgaaacg      540

ctgatggtga ttgaccatca gaaaaaaagc actcgtattc aggccagcct gtttgctccg      600

aatgaagaag aaaaacaacg tctcactgct cgcctgaacg aactacgtca gcaactgacc      660

gaagccgcgc cgccgctgcc ggtggtttcc gtgccgcata tgcgttgtga atgtaaccag      720

agcgatgaag agttcggtgg tgtagtgcgt ttgttgcaaa aagcgattcg cgccggagaa      780

attttccagg tggtgccatc tcgccgtttc tctctgccct gcccgtcacc gctggcagcc      840

tattacgtgc tgaaaaagag taatcccagc ccgtacatgt tttttatgca ggataatgat      900

ttcaccctgt ttggcgcgtc gccggaaagt tcgctcaagt atgacgccac cagccgccag      960

attgagattt acccgattgc cggaacacgt ccacgcggtc gtcgtgccga tggttcgctg     1020

gacagagacc tcgacagccg catcgaactg gagatgcgta ccgatcataa agagctttct     1080

gaacatctga tgctggtgga tctcgcccgt aatgacctgg cacgcatttg cacacccggc     1140

agccgctacg tcgccgatct caccaaagtt gaccgttact cttacgtgat gcacctagtc     1200

tcccgcgttg ttggtgagct gcgccacgat ctcgacgccc tgcacgctta ccgcgcctgt     1260

atgaatatgg ggacgttaag cggtgcaccg aaagtacgcg ctatgcagtt aattgccgaa     1320

gcagaaggtc gtcgacgcgg cagctacggc ggcgcggtag gttattttac cgcgcatggc     1380

gatctcgaca cctgcattgt gatccgctcg gcgctggtgg aaaacggtat cgccaccgtg     1440

caagccggtg ctggcgtagt ccttgattct gttccgcagt cggaagccga cgaaactcgt     1500

aataaagccc gcgctgtact gcgcgctatt gccaccgcgc atcatgcaca ggagacgttc     1560

ta                                                                    1562


<210> 880
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0029

<400> 880
tctagagttc acacaggaaa cctactagat g                                      31


<210> 881
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0030

<400> 881
tctagagatt aaagaggaga aatactagat g                                      31


<210> 882
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0031

<400> 882
tctagagtca cacaggaaac ctactagatg                                        30


<210> 883
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0032

<400> 883
tctagagtca cacaggaaag tactagatg                                         29


<210> 884
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0033

<400> 884
tctagagtca cacaggacta ctagatg                                           27


<210> 885
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0034

<400> 885
tctagagaaa gaggagaaat actagatg                                          28


<210> 886
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0035

<400> 886
tctagagatt aaagaggaga atactagatg                                        30


<210> 887
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_B0064

<400> 887
tctagagaaa gaggggaaat actagatg                                          28


<210> 888
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SYN23119 promoter

<400> 888
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaa                                                                    64


<210> 889
<211> 94
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SYN23119 promoter with RBS

<400> 889
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaagtgaat tatataaaag tgggaggtgc ccga                                   94


<210> 890
<211> 1225
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Pseudomonas fluorescens, codon optimized for expression
      in E. coli, driven by the SYN23119 Construct can be expressed
      from a plasmid, e.g., p15 or can be integrated into the 
      chromosome, e.g., at the HA3/4 site

<400> 890
ggaaaatttt tttaaaaaaa aaacttgaca gctagctcag tccttggtat aatgctagca       60

cgaagtgaat tatataaaag tgggaggtgc ccgaatgacg acccgaaatg attgcctagc      120

gttggatgca caggacagtc tggctccgct gcgccaacaa tttgcgctgc cggagggtgt      180

gatatacctg gatggcaatt cgctgggcgc acgtccggta gctgcgctgg ctcgcgcgca      240

ggctgtgatc gcagaagaat ggggcaacgg gttgatccgt tcatggaact ctgcgggctg      300

gcgtgatctg tctgaacgcc tgggtaatcg cctggctacc ctgattggtg cgcgcgatgg      360

ggaagtagtt gttactgata ccacctcgat taatctgttt aaagtgctgt cagcggcgct      420

gcgcgtgcaa gctacccgta gcccggagcg ccgtgttatc gtgactgaga cctcgaattt      480

cccgaccgac ctgtatattg cggaagggtt ggcggatatg ctgcaacaag gttacactct      540

gcgtttggtg gattcaccgg aagagctgcc acaggctata gatcaggaca ccgcggtggt      600

gatgctgacg cacgtaaatt ataaaaccgg ttatatgcac gacatgcagg ctctgaccgc      660

gttgagccac gagtgtgggg ctctggcgat ttgggatctg gcgcactctg ctggcgctgt      720

gccggtggac ctgcaccaag cgggcgcgga ctatgcgatt ggctgcacgt acaaatacct      780

gaatggcggc ccgggttcgc aagcgtttgt ttgggtttcg ccgcaactgt gcgacctggt      840

accgcagccg ctgtctggtt ggttcggcca tagtcgccaa ttcgcgatgg agccgcgcta      900

cgaaccttct aacggcattg ctcgctatct gtgcggcact cagcctatta ctagcttggc      960

tatggtggag tgcggcctgg atgtgtttgc gcagacggat atggcttcgc tgcgccgtaa     1020

aagtctggcg ctgactgatc tgttcatcga gctggttgaa caacgctgcg ctgcacacga     1080

actgaccctg gttactccac gtgaacacgc gaaacgcggc tctcacgtgt cttttgaaca     1140

ccccgagggt tacgctgtta ttcaagctct gattgatcgt ggcgtgatcg gcgattaccg     1200

tgagccacgt attatgcgtt tcggt                                           1225


<210> 891
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Lpp promoter from E. coli SEQ ID NO: 891

<400> 891
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgcta                                                                  66


<210> 892
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Lpp promoter from E. coli SEQ ID NO: 892

<400> 892
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgctagtga attatataaa agtgggaggt gcccga                                 96


<210> 893
<211> 1347
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Pseudomonas fluorescens kynureninase driven by Lpp promoter
      from E. coli SEQ ID NO: 893 Construct can be expressed from
      a plasmid, e.g., p15 or can be integrated into the 
      chromosome, e.g., at the HA3/4 site

<400> 893
ataagtgcct tcccatcaaa aaaatattct caacataaaa aactttgtgt aatacttgta       60

acgctagtga attatataaa agtgggaggt gcccgaatga cgacccgaaa tgattgccta      120

gcgttggatg cacaggacag tctggctccg ctgcgccaac aatttgcgct gccggagggt      180

gtgatatacc tggatggcaa ttcgctgggc gcacgtccgg tagctgcgct ggctcgcgcg      240

caggctgtga tcgcagaaga atggggcaac gggttgatcc gttcatggaa ctctgcgggc      300

tggcgtgatc tgtctgaacg cctgggtaat cgcctggcta ccctgattgg tgcgcgcgat      360

ggggaagtag ttgttactga taccacctcg attaatctgt ttaaagtgct gtcagcggcg      420

ctgcgcgtgc aagctacccg tagcccggag cgccgtgtta tcgtgactga gacctcgaat      480

ttcccgaccg acctgtatat tgcggaaggg ttggcggata tgctgcaaca aggttacact      540

ctgcgtttgg tggattcacc ggaagagctg ccacaggcta tagatcagga caccgcggtg      600

gtgatgctga cgcacgtaaa ttataaaacc ggttatatgc acgacatgca ggctctgacc      660

gcgttgagcc acgagtgtgg ggctctggcg atttgggatc tggcgcactc tgctggcgct      720

gtgccggtgg acctgcacca agcgggcgcg gactatgcga ttggctgcac gtacaaatac      780

ctgaatggcg gcccgggttc gcaagcgttt gtttgggttt cgccgcaact gtgcgacctg      840

gtaccgcagc cgctgtctgg ttggttcggc catagtcgcc aattcgcgat ggagccgcgc      900

tacgaacctt ctaacggcat tgctcgctat ctgtgcggca ctcagcctat tactagcttg      960

gctatggtgg agtgcggcct ggatgtgttt gcgcagacgg atatggcttc gctgcgccgt     1020

aaaagtctgg cgctgactga tctgttcatc gagctggttg aacaacgctg cgctgcacac     1080

gaactgaccc tggttactcc acgtgaacac gcgaaacgcg gctctcacgt gtcttttgaa     1140

caccccgagg gttacgctgt tattcaagct ctgattgatc gtggcgtgat cggcgattac     1200

cgtgagccac gtattatgcg tttcggtttc actcctctgt atactacttt tacggaagtt     1260

tgggatgcag tacaaatcct gggcgaaatc ctggatcgta agacttgggc gcaggctcag     1320

tttcaggtgc gccactctgt tacttaa                                         1347


<210> 894
<211> 138
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fliC-FliC20

<400> 894
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaacgtggg tactccttaa       60

attgggttcg aatggaccat ggcacaagtc attaatacca acagcctctc gctgatcact      120

caaaataata tcaacaag                                                    138


<210> 895
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> fliC-RBS

<400> 895
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaactacga acacttacag       60

gaggtaccca                                                              70


<210> 896
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> fliC-RBS

<400> 896
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaacaagta taaactctgg       60

gaggttccta                                                              70


<210> 897
<211> 70
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> fliC-RBS

<400> 897
tgacggcgat tgagccgacg ggtggaaacc caaaacgtaa tcaactcaaa tcccttaata       60

aggaggtaaa                                                              70


<210> 898
<211> 106
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> RBS-phoA

<400> 898
ctctagaaat aattttgttt aactttaaga aggagatata catatgaaac aaagcactat       60

tgcactggca ctcttaccgt tactgtttac ccctgtgaca aaagcg                     106


<210> 899
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> phoA

<400> 899
atgaaacaaa gcactattgc actggcactc ttaccgttac tgtttacccc tgtgacaaaa       60

gcg                                                                     63


<210> 900
<211> 109
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> RBS-ompF

<400> 900
ctctagaaat aattttgttt aactttaaga aggagatata catatgatga agcgcaatat       60

tctggcagtg atcgtccctg ctctgttagt agcaggtact gcaaacgct                  109


<210> 901
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> ompF

<400> 901
atgatgaagc gcaatattct ggcagtgatc gtccctgctc tgttagtagc aggtactgca       60

aacgct                                                                  66


<210> 902
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> RBS-cvaC

<400> 902
ctctagaaat aattttgttt aactttaaga aggagatata catatgagaa ctctgactct       60

aaatgaatta gattctgttt ctggtggt                                          88


<210> 903
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> cvaC

<400> 903
atgagaactc tgactctaaa tgaattagat tctgtttctg gtggt                       45


<210> 904
<211> 88
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> RBS-phoA (Optimized)

<400> 904
gacgccagag agttaagggg gttaaatgaa acaatcgacc atcgcattgg cgctgcttcc       60

tctattgttc acaccggtga caaaggca                                          88


<210> 905
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Optimized phoA

<400> 905
atgaaacaat cgaccatcgc attggcgctg cttcctctat tgttcacacc ggtgacaaag       60

gca                                                                     63


<210> 906
<211> 160
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> RBS-TorA

<400> 906
ctctagaaat aattttgttt aactttaaga aggagatata catatgaaca ataacgatct       60

ctttcaggca tcacgtcggc gttttctggc acaactcggc ggcttaaccg tcgccgggat      120

gctggggccg tcattgttaa cgccgcgacg tgcgactgcg                            160


<210> 907
<211> 117
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> TorA

<400> 907
atgaacaata acgatctctt tcaggcatca cgtcggcgtt ttctggcaca actcggcggc       60

ttaaccgtcg ccgggatgct ggggccgtca ttgttaacgc cgcgacgtgc gactgcg         117


<210> 908
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> RBS-TorA alternate

<400> 908
cccacattcg aggtactaaa tgaacaataa cgatctcttt caggcatcac gtcggcgttt       60

tctggcacaa ctcggcggct taaccgtcgc cgggatgctg gggacgtcat tgttaacgcc      120

gcgccgtgcg actgcggcgc aagcggcg                                         148


<210> 909
<211> 129
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> TorA (alternate)

<400> 909
atgaacaata acgatctctt tcaggcatca cgtcggcgtt ttctggcaca actcggcggc       60

ttaaccgtcg ccgggatgct ggggacgtca ttgttaacgc cgcgccgtgc gactgcggcg      120

caagcggcg                                                              129


<210> 910
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> RBS-fdnG

<400> 910
accctattac acacctaagg aggccaaata catggacgtc agtcgcagac aattttttaa       60

aatctgcgcg ggcggtatgg cgggaacaac agtagcagca ttgggctttg ccccgaagca      120

agcactggct                                                             130


<210> 911
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> fdnG

<400> 911
atggacgtca gtcgcagaca attttttaaa atctgcgcgg gcggtatggc gggaacaaca       60

gtagcagcat tgggctttgc cccgaagcaa gcactggct                              99


<210> 912
<211> 168
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> RBS-dmsA

<400> 912
tacgcaaaaa acataattta agagaggata aacatgaaaa cgaaaatccc tgatgcggta       60

ttggctgctg aggtgagtcg ccgtggtttg gtaaaaacga cagcgatcgg cggcctggca      120

atggccagca gcgcattaac attacctttt agtcggattg cgcacgct                   168


<210> 913
<211> 135
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> dmsA

<400> 913
atgaaaacga aaatccctga tgcggtattg gctgctgagg tgagtcgccg tggtttggta       60

aaaacgacag cgatcggcgg cctggcaatg gccagcagcg cattaacatt accttttagt      120

cggattgcgc acgct                                                       135


<210> 914
<211> 712
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> TetR/TetA Promoter

<400> 914
gaattcgtta agacccactt tcacatttaa gttgtttttc taatccgcat atgatcaatt       60

caaggccgaa taagaaggct ggctctgcac cttggtgatc aaataattcg atagcttgtc      120

gtaataatgg cggcatacta tcagtagtag gtgtttccct ttcttcttta gcgacttgat      180

gctcttgatc ttccaatacg caacctaaag taaaatgccc cacagcgctg agtgcatata      240

atgcattctc tagtgaaaaa ccttgttggc ataaaaaggc taattgattt tcgagagttt      300

catactgttt ttctgtaggc cgtgtaccta aatgtacttt tgctccatcg cgatgactta      360

gtaaagcaca tctaaaactt ttagcgttat tacgtaaaaa atcttgccag ctttcccctt      420

ctaaagggca aaagtgagta tggtgcctat ctaacatctc aatggctaag gcgtcgagca      480

aagcccgctt attttttaca tgccaataca atgtaggctg ctctacacct agcttctggg      540

cgagtttacg ggttgttaaa ccttcgattc cgacctcatt aagcagctct aatgcgctgt      600

taatcacttt acttttatct aatctagaca tcattaattc ctaatttttg ttgacactct      660

atcattgata gagttatttt accactccct atcagtgata gagaaaagtg aa              712


<210> 915
<211> 104
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> fliC Promoter

<400> 915
agcgggaata aggggcagag aaaagagtat ttcgtcgact aacaaaaaat ggctgtttgt       60

gaaaaaaatt ctaaaggttg ttttacgaca gacgataaca gggt                       104


<210> 916
<211> 162
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> FnrS Promoter

<400> 916
ggtaccagtt gttcttattg gtggtgttgc tttatggttg catcgtagta aatggttgta       60

acaaaagcaa tttttccggc tgtctgtata caaaaacgcc gcaaagtttg agcgaagtca      120

ataaactctc tacccattca gggcaatatc tctcttggat cc                         162


<210> 917
<211> 358
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> DOM Construct Terminator

<400> 917
cacatttccc cgaaaagtgc cgatggcccc ccgatggtag tgtggcccat gcgagagtag       60

ggaactgcca ggcatcaaat aaaacgaaag gctcagtcga aagactgggc ctttcgtttt      120

atctgttgtt tgtcggtgaa cgctctcctg agtaggacaa atccgccggg agcggatttg      180

aacgttgcga agcaacggcc cggagggtgg cgggcaggac gcccgccata aactgccagg      240

catcaaatta agcagaaggc catcctgacg gatggccttt ttgcgtggcc agtgccaagc      300

ttgcatgcag attgcagcat tacacgtctt gagcgattgt gtaggctgga gctgcttc        358


<210> 918
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> FRT Site

<400> 918
gaagttccta tactttctag agaataggaa cttcggaata ggaacttc                    48


<210> 919
<211> 1345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Kanamycin Resistance Cassette (for integration in
      between FRT sites)

<400> 919
aagatcccct cacgctgccg caagcactca gggcgcaagg gctgctaaag gaagcggaac       60

acgtagaaag ccagtccgca gaaacggtgc tgaccccgga tgaatgtcag ctactgggct      120

atctggacaa gggaaaacgc aagcgcaaag agaaagcagg tagcttgcag tgggcttaca      180

tggcgatagc tagactgggc ggttttatgg acagcaagcg aaccggaatt gccagctggg      240

gcgccctctg gtaaggttgg gaagccctgc aaagtaaact ggatggcttt cttgccgcca      300

aggatctgat ggcgcagggg atcaagatct gatcaagaga caggatgagg atcgtttcgc      360

atgattgaac aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc      420

ggctatgact gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca      480

gcgcaggggc gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg      540

caggacgagg cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg      600

ctcgacgttg tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag      660

gatctcctgt catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg      720

cggcggctgc atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc      780

atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa      840

gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac      900

ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat      960

ggccgctttt ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac     1020

atagcgttgg ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc     1080

ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt     1140

gacgagttct tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc     1200

tgccatcacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg     1260

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg     1320

cccaccccag cttcaaaagc gctct                                           1345


<210> 920
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IL-12a construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)

<400> 920
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210> 921
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IL-12a construct with a N terminal PhoA
      secretion

<400> 921
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
            20                  25                  30          


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
        35                  40                  45              


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
    50                  55                  60                  


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
65                  70                  75                  80  


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
                85                  90                  95      


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
            100                 105                 110         


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
        115                 120                 125             


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
    130                 135                 140                 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
145                 150                 155                 160 


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
                165                 170                 175     


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
            180                 185                 190         


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
        195                 200                 205             


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215             


<210> 922
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IL-12a construct with a N terminal TorA
      secretion tag (sec-dependent secretion system)

<400> 922
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Arg Asn Leu Pro Val Ala Thr Pro Asp 
        35                  40                  45              


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
    50                  55                  60                  


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
65                  70                  75                  80  


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
                85                  90                  95      


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
        115                 120                 125             


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
145                 150                 155                 160 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
                165                 170                 175     


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
            180                 185                 190         


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
        195                 200                 205             


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
    210                 215                 220                 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
225                 230                 235     


<210> 923
<211> 328
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IL-12b construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)

<400> 923
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210> 924
<211> 327
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IL-12b construct with a N terminal PhoA
      secretion tag

<400> 924
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
    50                  55                  60                  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
65                  70                  75                  80  


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
                85                  90                  95      


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
            100                 105                 110         


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
        115                 120                 125             


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
    130                 135                 140                 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
145                 150                 155                 160 


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
                165                 170                 175     


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
            180                 185                 190         


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
        195                 200                 205             


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
    210                 215                 220                 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
225                 230                 235                 240 


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
                245                 250                 255     


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
            260                 265                 270         


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
        275                 280                 285             


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
    290                 295                 300                 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
305                 310                 315                 320 


Trp Ala Ser Val Pro Cys Ser 
                325         


<210> 925
<211> 345
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IL-12 construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)

<400> 925
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr 
        35                  40                  45              


Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val 
    50                  55                  60                  


Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp 
65                  70                  75                  80  


Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val 
                85                  90                  95      


Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
            100                 105                 110         


Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile 
        115                 120                 125             


Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr 
    130                 135                 140                 


Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp 
145                 150                 155                 160 


Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser 
                165                 170                 175     


Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu 
            180                 185                 190         


Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val 
        195                 200                 205             


Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
    210                 215                 220                 


Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
225                 230                 235                 240 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
                245                 250                 255     


Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
            260                 265                 270         


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
        275                 280                 285             


Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp 
    290                 295                 300                 


Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn 
305                 310                 315                 320 


Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp 
                325                 330                 335     


Ser Glu Trp Ala Ser Val Pro Cys Ser 
            340                 345 


<210> 926
<211> 219
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> murine IL-12a construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)

<400> 926
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215                 


<210> 927
<211> 218
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> murine IL-12a construct with a N terminal PhoA
      secretion tag

<400> 927
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
            20                  25                  30          


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
        35                  40                  45              


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
    50                  55                  60                  


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
65                  70                  75                  80  


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
                85                  90                  95      


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
            100                 105                 110         


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
        115                 120                 125             


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
    130                 135                 140                 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
145                 150                 155                 160 


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
                165                 170                 175     


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
            180                 185                 190         


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
        195                 200                 205             


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    210                 215             


<210> 928
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> murine IL-12a construct with a N terminal TorA
      secretion tag (sec-dependent secretion system)

<400> 928
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Arg Asn Leu Pro Val Ala Thr Pro Asp 
        35                  40                  45              


Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
    50                  55                  60                  


Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
65                  70                  75                  80  


Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
                85                  90                  95      


Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
            100                 105                 110         


Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
        115                 120                 125             


Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
    130                 135                 140                 


Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
145                 150                 155                 160 


Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
                165                 170                 175     


Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
            180                 185                 190         


Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
        195                 200                 205             


Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
    210                 215                 220                 


Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
225                 230                 235     


<210> 929
<211> 335
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> murine IL-12b construct with a N terminal OmpF
      secretion tag (sec-dependent secretion system)

<400> 929
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln 
    50                  55                  60                  


Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys 
65                  70                  75                  80  


Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr 
                85                  90                  95      


Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp 
            100                 105                 110         


Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys 
        115                 120                 125             


Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln 
    130                 135                 140                 


Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 
145                 150                 155                 160 


Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys 
                165                 170                 175     


Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln 
            180                 185                 190         


Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu 
        195                 200                 205             


Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser 
    210                 215                 220                 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
225                 230                 235                 240 


Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     


Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val 
            260                 265                 270         


Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys 
        275                 280                 285             


Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln 
    290                 295                 300                 


Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 
305                 310                 315                 320 


Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 335 


<210> 930
<211> 334
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> murine IL-12b construct with a N terminal PhoA
      secretion tag

<400> 930
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 
            20                  25                  30          


Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 
        35                  40                  45              


Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 
    50                  55                  60                  


His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 
65                  70                  75                  80  


Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 
                85                  90                  95      


Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 
            100                 105                 110         


Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 
        115                 120                 125             


Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 
    130                 135                 140                 


Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp 
145                 150                 155                 160 


Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val 
                165                 170                 175     


Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu 
            180                 185                 190         


Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala 
        195                 200                 205             


Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe 
    210                 215                 220                 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met 
225                 230                 235                 240 


Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
                245                 250                 255     


Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg 
            260                 265                 270         


Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn 
        275                 280                 285             


Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 
    290                 295                 300                 


Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser 
305                 310                 315                 320 


Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
                325                 330                 


<210> 931
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> murine IL-12b construct with a N terminal TorA
      secretion tag (sec-dependent secretion system)

<400> 931
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Met Trp Glu Leu Glu Lys Asp Val Tyr 
        35                  40                  45              


Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn 
    50                  55                  60                  


Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp 
65                  70                  75                  80  


Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val 
                85                  90                  95      


Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
            100                 105                 110         


Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile 
        115                 120                 125             


Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys 
    130                 135                 140                 


Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val 
145                 150                 155                 160 


Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser 
                165                 170                 175     


Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu 
            180                 185                 190         


Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys 
        195                 200                 205             


Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu 
    210                 215                 220                 


Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr 
225                 230                 235                 240 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
                245                 250                 255     


Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr 
            260                 265                 270         


Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe 
        275                 280                 285             


Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly 
    290                 295                 300                 


Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val 
305                 310                 315                 320 


Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr 
                325                 330                 335     


Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 
            340                 345                 350         


<210> 932
<211> 149
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human GMCSF construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)

<400> 932
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr 
            20                  25                  30          


Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu 
        35                  40                  45              


Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val 
    50                  55                  60                  


Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg 
65                  70                  75                  80  


Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys 
                85                  90                  95      


Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro 
            100                 105                 110         


Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe 
        115                 120                 125             


Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp 
    130                 135                 140                 


Glu Pro Val Gln Glu 
145                 


<210> 933
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human GMCSF construct with a N terminal PhoA secretion
      tag

<400> 933
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln 
            20                  25                  30          


Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn 
        35                  40                  45              


Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile 
    50                  55                  60                  


Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu 
65                  70                  75                  80  


Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly 
                85                  90                  95      


Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr 
            100                 105                 110         


Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys 
        115                 120                 125             


Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu 
    130                 135                 140                 


Pro Val Gln Glu 
145             


<210> 934
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human GMCSF construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)

<400> 934
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Ala Pro Ala Arg Ser Pro Ser Pro Ser 
        35                  40                  45              


Thr Gln Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu 
    50                  55                  60                  


Leu Asn Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu 
65                  70                  75                  80  


Val Ile Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr 
                85                  90                  95      


Arg Leu Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu 
            100                 105                 110         


Lys Gly Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro 
        115                 120                 125             


Pro Thr Pro Glu Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser 
    130                 135                 140                 


Phe Lys Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys 
145                 150                 155                 160 


Trp Glu Pro Val Gln Glu 
                165     


<210> 935
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human Il-15 construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)

<400> 935
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
            20                  25                  30          


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
        35                  40                  45              


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
    50                  55                  60                  


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
65                  70                  75                  80  


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
                85                  90                  95      


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
            100                 105                 110         


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
        115                 120                 125             


Val Gln Met Phe Ile Asn Thr Ser 
    130                 135     


<210> 936
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human Il-15 construct with a N terminal PhoA secretion
      tag

<400> 936
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210> 937
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human Il-15 construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)

<400> 937
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Asn Trp Val Asn Val Ile Ser Asp Leu 
        35                  40                  45              


Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu 
    50                  55                  60                  


Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys 
65                  70                  75                  80  


Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala 
                85                  90                  95      


Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser 
            100                 105                 110         


Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu 
        115                 120                 125             


Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His 
    130                 135                 140                 


Ile Val Gln Met Phe Ile Asn Thr Ser 
145                 150             


<210> 938
<211> 199
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human TNFa construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)

<400> 938
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp 
            20                  25                  30          


Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg 
        35                  40                  45              


Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala 
    50                  55                  60                  


Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala 
65                  70                  75                  80  


Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly 
                85                  90                  95      


Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro 
            100                 105                 110         


Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser 
        115                 120                 125             


Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln 
    130                 135                 140                 


Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile 
145                 150                 155                 160 


Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala 
                165                 170                 175     


Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val 
            180                 185                 190         


Tyr Phe Gly Ile Ile Ala Leu 
        195                 


<210> 939
<211> 198
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human TNFa construct with a N terminal PhoA secretion
      tag

<400> 939
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu 
            20                  25                  30          


Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr 
        35                  40                  45              


Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu 
    50                  55                  60                  


Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn 
65                  70                  75                  80  


Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu 
                85                  90                  95      


Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser 
            100                 105                 110         


Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr 
        115                 120                 125             


Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg 
    130                 135                 140                 


Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr 
145                 150                 155                 160 


Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu 
                165                 170                 175     


Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr 
            180                 185                 190         


Phe Gly Ile Ile Ala Leu 
        195             


<210> 940
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human TNFa construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)

<400> 940
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Gly Pro Gln Arg Glu Glu Phe Pro Arg 
        35                  40                  45              


Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser 
    50                  55                  60                  


Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln 
65                  70                  75                  80  


Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu 
                85                  90                  95      


Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu 
            100                 105                 110         


Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys 
        115                 120                 125             


Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val 
    130                 135                 140                 


Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys 
145                 150                 155                 160 


Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro 
                165                 170                 175     


Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser 
            180                 185                 190         


Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln 
        195                 200                 205             


Val Tyr Phe Gly Ile Ile Ala Leu 
    210                 215     


<210> 941
<211> 160
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IFNg construct with a N terminal OmpF secretion
      tag (sec-dependent secretion system)

<400> 941
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn 
            20                  25                  30          


Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly 
        35                  40                  45              


Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg 
    50                  55                  60                  


Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys 
65                  70                  75                  80  


Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys 
                85                  90                  95      


Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp 
            100                 105                 110         


Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln 
        115                 120                 125             


Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro 
    130                 135                 140                 


Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
145                 150                 155                 160 


<210> 942
<211> 159
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IFNg construct with a N terminal PhoA secretion
      tag

<400> 942
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu 
            20                  25                  30          


Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr 
        35                  40                  45              


Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys 
    50                  55                  60                  


Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn 
65                  70                  75                  80  


Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu 
                85                  90                  95      


Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp 
            100                 105                 110         


Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg 
        115                 120                 125             


Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala 
    130                 135                 140                 


Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
145                 150                 155                 


<210> 943
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> human IFNg construct with a N terminal TorA secretion
      tag (sec-dependent secretion system)

<400> 943
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Gln Asp Pro Tyr Val Lys Glu Ala Glu 
        35                  40                  45              


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
    50                  55                  60                  


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
65                  70                  75                  80  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
                85                  90                  95      


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
            100                 105                 110         


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
        115                 120                 125             


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
    130                 135                 140                 


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
145                 150                 155                 160 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
                165                 170                 175     


Gly 
    


<210> 944

<400> 944
000


<210> 945

<400> 945
000


<210> 946

<400> 946
000


<210> 947

<400> 947
000


<210> 948

<400> 948
000


<210> 949

<400> 949
000


<210> 950

<400> 950
000


<210> 951

<400> 951
000


<210> 952

<400> 952
000


<210> 953
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> human IL-12a construct with a N terminal PhoA
      secretion tag

<400> 953
atgaaacaga gcacaattgc tctggccttg ttgccattac tgtttacccc tgttactaag       60

gctaggaacc tgcctgtggc aacaccagac cctgggatgt tcccttgctt acatcattcc      120

cagaacctgt tgcgtgcggt gtctaacatg ctgcagaaag ccaggcagac gctggaattc      180

tacccatgca cttccgaaga gatagatcat gaagacatta cgaaagacaa aacctcaacg      240

gttgaagcat gcttacctct ggaattgact aagaatgaat cgtgcttaaa ctcaagagag      300

accagtttca tcactaatgg ctcttgctta gcgtcgcgca agaccagctt catgatggcg      360

ctctgcctaa gtagcatcta cgaggacctc aaaatgtacc aagttgaatt taaaactatg      420

aatgccaaac ttctaatgga cccaaaaaga cagatatttt tagatcagaa tatgcttgcg      480

gttattgacg aactcatgca ggcattgaat tttaattccg agacggtgcc acaaaaaagt      540

tctttggagg agccggactt ttacaagaca aaaatcaagc tgtgcatact tcttcacgca      600

ttcagaatac gggccgttac gatcgatcgc gtcatgtcgt atcttaatgc gagctga         657


<210> 954
<211> 987
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> human IL-12b construct with a N terminal PhoA
      secretion tag

<400> 954
atgaagcaga gcacgatcgc attggcgttg ctaccgctgt tgtttacccc ggtcacaaaa       60

gccatctggg aactgaaaaa agatgtttat gtagttgaac tggattggta cccggatgca      120

cccggtgaga tggtggtttt gacctgcgac acgccggaag aagatggcat aacgtggacc      180

ctggatcaaa gctctgaagt tctgggttca ggtaagacat tgacgatcca agtaaaagaa      240

tttggcgacg caggtcagta cacctgccac aaaggtggcg aagttctgtc gcactcactc      300

ctgctcctgc acaaaaaaga ggatggcatc tggagtactg atatcctaaa ggatcaaaaa      360

gaacctaaaa acaaaacgtt cttgcgctgt gaagcgaaga actatagtgg tcgctttacg      420

tgctggtggt tgactaccat ttccaccgat ttgacctttt ctgttaagag ttcgcgcggc      480

tcgtcagatc cgcagggcgt tacttgcggt gcggcgacgc tgtcagctga gagagttcgt      540

ggggacaaca aagagtacga atatagtgta gaatgtcaag aggattcggc gtgcccggca      600

gcagaggagt ctctccccat tgaagttatg gtggacgcag tgcataaact gaaatatgag      660

aattacacat caagcttttt tattcgcgat atcatcaaac cggatcctcc aaaaaatctg      720

caactaaagc ccctgaaaaa ttcgcgccaa gttgaggtga gctgggaata tccggatact      780

tggtcgacac cgcattctta tttctcactg accttctgcg ttcaggttca aggtaaatca      840

aaacgagaaa aaaaggatcg cgtctttacc gacaaaacgt ctgctactgt aatctgccgc      900

aagaatgcgt caatttctgt acgtgcgcaa gatcgctact actctagtag ttggtctgaa      960

tgggcttcag tgccatgctc ctgatga                                          987


<210> 955
<211> 657
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> murine IL-12a construct with a N terminal PhoA
      secretion tag

<400> 955
atgaaacaga gtacgatagc cctagccctg ttgccgctcc tgttcacccc cgttactaaa       60

gcacgtaacc ttccggtggc cacgccagat ccgggcatgt tcccgtgctt acaccattcc      120

cagaatctgc tgcgcgctgt gagtaatatg ctgcagaagg cgagacaaac tttggaattt      180

tacccgtgca cttcggagga gattgaccat gaggatatca caaaagacaa aaccagtaca      240

gtggaagcct gcctgcccct tgaactgact aaaaatgaga gttgtttaaa ttcacgcgaa      300

accagcttca ttactaacgg aagctgctta gcatcgcgga aaaccagttt tatgatggcc      360

ctttgccttt catctattta cgaggacctt aaaatgtatc aagttgaatt taagactatg      420

aacgcgaaac tgctaatgga tcccaagcga caaatctttc ttgatcaaaa tatgttggct      480

gttattgatg aactgatgca agccctgaat tttaactcag aaaccgtacc tcagaaatcg      540

agtttagaag aacccgattt ctacaaaact aaaatcaagt tgtgtatcct tttacatgcc      600

ttccggattc gggccgtcac tattgatcgc gtgatgtcgt acttgaatgc ctcctaa         657


<210> 956
<211> 1005
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> murine IL-12b construct with a N terminal PhoA
      secretion tag

<400> 956
atgaaacaga gcacgatcgc acttgccctt ttgccgctgt tatttacccc agtgacgaaa       60

gccatgtggg aattggaaaa agacgtgtat gttgttgaag ttgactggac tccggacgcg      120

cctggtgaaa ctgttaatct gacttgtgat acaccggagg aagatgatat aacttggact      180

agcgatcaac gacacggcgt aatcggctct ggtaagactt tgaccattac tgtgaaggaa      240

ttcttggatg cggggcaata tacgtgtcat aaaggcggcg agacgctgtc acactctcac      300

ctgttgttac ataaaaaaga gaatggtata tggtctacgg agatcttgaa aaactttaaa      360

aacaaaactt ttttgaagtg tgaggctcca aactattctg gtcgctttac ctgtagttgg      420

ttggtgcaac gtaacatgga tctcaaattt aacataaagt cgtcttcgtc ttctcccgat      480

agccgagcgg ttacctgtgg catggctagt ttgtcggcgg agaaggtgac cttggatcaa      540

cgtgattatg aaaaatatag cgtttcgtgc caagaggacg ttacgtgccc taccgctgaa      600

gagactttgc cgattgaatt ggcactggaa gcacgacaac aaaataaata cgagaattac      660

tcaactagtt tcttcatccg agatatcata aaaccggacc ccccgaagaa tctgcaaatg      720

aaaccgctta aaaattcaca ggtagaggtt tcgtgggagt acccggatag ttggtctacg      780

cctcattcgt attttagcct gaaatttttc gttcgaatac agcgaaaaaa agagaagatg      840

aaagaaactg aagaagggtg taaccaaaaa ggtgcatttc tggtggagaa aactagcacc      900

gaggttcaat gcaaaggcgg taacgtgtgc gtacaagctc aagaccgtta ttataacagt      960

agctgttcta aatgggcttg cgtgccctgc cgcgtgagat catga                     1005


<210> 957
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> human Il-15 construct with a N terminal PhoA secretion
      tag

<400> 957
atgaagcaat ctacgatcgc actagcgtta ctgccgttat tgtttactcc tgtgactaag       60

gctaattggg ttaatgttat atctgatttg aaaaaaatag aggatctgat tcaatcaatg      120

cacatagatg cgactctgta tactgagagc gatgtgcacc cgagttgcaa agttactgct      180

atgaaatgtt ttctgctgga gctgcaagtt atctctctgg agagtggtga tgcgtctatt      240

cacgatactg ttgagaatct gattattctg gctaataact cgctgtcaag taatgggaat      300

gttacggaat ctggctgtaa ggagtgtgaa gaattagaag aaaaaaatat taaagagttt      360

ctgcagagtt ttgtgcacat tgttcagatg tttatcaata ctagctga                   408


<210> 958
<211> 447
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> human GMCSF construct with a N terminal PhoA secretion
      tag

<400> 958
atgaagcaat ctacgatcgc gttggcctta ctgcccctgt tattcacacc cgtgaccaaa       60

gcggcaccgg cccgcagccc atcaccgtca actcaacctt gggaacatgt aaatgctatt      120

caagaagctc gccgcctgtt gaatttgagt cgcgatactg cagcagagat gaatgagact      180

gtagaggtga tttcagaaat gtttgacctg caggagccga cttgtttgca aactcgcctg      240

gagctgtaca aacaaggcct gcgtggctcg ctgactaaac tgaaaggtcc tctgacgatg      300

atggcttctc attataaaca acactgcccg cctactccgg agacgtcttg cgcgacccag      360

ataattactt ttgaatcttt taaagagaat ctgaaagact ttctgctggt tatcccgttt      420

gattgttggg aaccggttca agaataa                                          447


<210> 959
<211> 597
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> human TNFa construct with a N terminal PhoA secretion
      tag

<400> 959
atgaaacaat caacgatcgc tctggctctg cttccgctgc tctttactcc agttactaaa       60

gcgggtccgc agagggaaga attcccgcgc gatttgagcc tgatttcacc tcttgctcag      120

gctgtccgct cctcttcgcg taccccctcg gataaacctg tcgcgcacgt ggttgcgaac      180

ccgcaagcgg aagggcagct gcaatggtta aaccgccggg ctaatgcact gctggctaat      240

ggagttgagt tacgcgacaa ccaacttgtc gttccttcgg aagggctgta tctgatctat      300

tcacaggttc tctttaaagg gcagggttgc ccatcaaccc acgtgctcct gacacacacg      360

atcagtcgta tcgcggtatc ctatcagacg aaagttaacc tcctgtcagc gattaaatcg      420

ccgtgtcaga gagaaactcc agagggtgcg gaagctaaac cgtggtatga acctatttat      480

cttggtggag ttttccagtt ggaaaaaggt gatagactgt cggcagagat caatcgccct      540

gattacctgg atttcgctga gtcgggtcag gtttatttcg gaattattgc actgtga         597


<210> 960
<211> 480
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> human IFNg construct with a N terminal PhoA secretion
      tag

<400> 960
atgaagcaat ctacgatagc actggcgttg ctgccgctgc tgttcacccc ggttaccaag       60

gcgcaggatc cttacgttaa agaagcagag aatctgaaaa aatactttaa tgcaggccac      120

agcgatgtgg cagataatgg cacgttattc ctgggcattc tgaaaaattg gaaagaagaa      180

tctgaccgga agatcatgca atctcagatc gtatcatttt atttcaagtt gtttaaaaac      240

ttcaaggatg accagtcgat tcaaaaatca gtggaaacga tcaaagaaga tatgaacgtt      300

aagttcttca actcaaataa aaaaaaacgc gatgatttcg aaaaactgac taattattcg      360

gtaactgatt tgaatgttca gcgcaaggcg attcatgaat tgattcaggt tatggcagaa      420

ctgtcgccag cggcaaaaac gggtaaacga aaacgttctc agatgttgtt tcgtggttga      480


<210> 961

<400> 961
000


<210> 962

<400> 962
000


<210> 963

<400> 963
000


<210> 964

<400> 964
000


<210> 965
<211> 2531
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet.phoA-hIL12b-phoA-hIL12a

<400> 965
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaaataag tcataaatag ggagtccaaa atgaagcaga      780

gcacgatcgc attggcgttg ctaccgctgt tgtttacccc ggtcacaaaa gccatctggg      840

aactgaaaaa agatgtttat gtagttgaac tggattggta cccggatgca cccggtgaga      900

tggtggtttt gacctgcgac acgccggaag aagatggcat aacgtggacc ctggatcaaa      960

gctctgaagt tctgggttca ggtaagacat tgacgatcca agtaaaagaa tttggcgacg     1020

caggtcagta cacctgccac aaaggtggcg aagttctgtc gcactcactc ctgctcctgc     1080

acaaaaaaga ggatggcatc tggagtactg atatcctaaa ggatcaaaaa gaacctaaaa     1140

acaaaacgtt cttgcgctgt gaagcgaaga actatagtgg tcgctttacg tgctggtggt     1200

tgactaccat ttccaccgat ttgacctttt ctgttaagag ttcgcgcggc tcgtcagatc     1260

cgcagggcgt tacttgcggt gcggcgacgc tgtcagctga gagagttcgt ggggacaaca     1320

aagagtacga atatagtgta gaatgtcaag aggattcggc gtgcccggca gcagaggagt     1380

ctctccccat tgaagttatg gtggacgcag tgcataaact gaaatatgag aattacacat     1440

caagcttttt tattcgcgat atcatcaaac cggatcctcc aaaaaatctg caactaaagc     1500

ccctgaaaaa ttcgcgccaa gttgaggtga gctgggaata tccggatact tggtcgacac     1560

cgcattctta tttctcactg accttctgcg ttcaggttca aggtaaatca aaacgagaaa     1620

aaaaggatcg cgtctttacc gacaaaacgt ctgctactgt aatctgccgc aagaatgcgt     1680

caatttctgt acgtgcgcaa gatcgctact actctagtag ttggtctgaa tgggcttcag     1740

tgccatgctc ctgatgagaa accctacgga ggaggttaat ttatgaaaca gagcacaatt     1800

gctctggcct tgttgccatt actgtttacc cctgttacta aggctaggaa cctgcctgtg     1860

gcaacaccag accctgggat gttcccttgc ttacatcatt cccagaacct gttgcgtgcg     1920

gtgtctaaca tgctgcagaa agccaggcag acgctggaat tctacccatg cacttccgaa     1980

gagatagatc atgaagacat tacgaaagac aaaacctcaa cggttgaagc atgcttacct     2040

ctggaattga ctaagaatga atcgtgctta aactcaagag agaccagttt catcactaat     2100

ggctcttgct tagcgtcgcg caagaccagc ttcatgatgg cgctctgcct aagtagcatc     2160

tacgaggacc tcaaaatgta ccaagttgaa tttaaaacta tgaatgccaa acttctaatg     2220

gacccaaaaa gacagatatt tttagatcag aatatgcttg cggttattga cgaactcatg     2280

caggcattga attttaattc cgagacggtg ccacaaaaaa gttctttgga ggagccggac     2340

ttttacaaga caaaaatcaa gctgtgcata cttcttcacg cattcagaat acgggccgtt     2400

acgatcgatc gcgtcatgtc gtatcttaat gcgagctgaa aataaaacga aaggctcagt     2460

cgaaagactg ggcctttcgt tttatctgtt ggttccttat catctggcga atcggaccca     2520

caagagcact g                                                          2531


<210> 966
<211> 2549
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet.phoA-mIL12b-phoA-mIL12a

<400> 966
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaatgtta cacatctaag gagaaacatt atgaaacaga      780

gcacgatcgc acttgccctt ttgccgctgt tatttacccc agtgacgaaa gccatgtggg      840

aattggaaaa agacgtgtat gttgttgaag ttgactggac tccggacgcg cctggtgaaa      900

ctgttaatct gacttgtgat acaccggagg aagatgatat aacttggact agcgatcaac      960

gacacggcgt aatcggctct ggtaagactt tgaccattac tgtgaaggaa ttcttggatg     1020

cggggcaata tacgtgtcat aaaggcggcg agacgctgtc acactctcac ctgttgttac     1080

ataaaaaaga gaatggtata tggtctacgg agatcttgaa aaactttaaa aacaaaactt     1140

ttttgaagtg tgaggctcca aactattctg gtcgctttac ctgtagttgg ttggtgcaac     1200

gtaacatgga tctcaaattt aacataaagt cgtcttcgtc ttctcccgat agccgagcgg     1260

ttacctgtgg catggctagt ttgtcggcgg agaaggtgac cttggatcaa cgtgattatg     1320

aaaaatatag cgtttcgtgc caagaggacg ttacgtgccc taccgctgaa gagactttgc     1380

cgattgaatt ggcactggaa gcacgacaac aaaataaata cgagaattac tcaactagtt     1440

tcttcatccg agatatcata aaaccggacc ccccgaagaa tctgcaaatg aaaccgctta     1500

aaaattcaca ggtagaggtt tcgtgggagt acccggatag ttggtctacg cctcattcgt     1560

attttagcct gaaatttttc gttcgaatac agcgaaaaaa agagaagatg aaagaaactg     1620

aagaagggtg taaccaaaaa ggtgcatttc tggtggagaa aactagcacc gaggttcaat     1680

gcaaaggcgg taacgtgtgc gtacaagctc aagaccgtta ttataacagt agctgttcta     1740

aatgggcttg cgtgccctgc cgcgtgagat catgagaaga agattattga agaggtccgc     1800

atgaaacaga gtacgatagc cctagccctg ttgccgctcc tgttcacccc cgttactaaa     1860

gcacgtaacc ttccggtggc cacgccagat ccgggcatgt tcccgtgctt acaccattcc     1920

cagaatctgc tgcgcgctgt gagtaatatg ctgcagaagg cgagacaaac tttggaattt     1980

tacccgtgca cttcggagga gattgaccat gaggatatca caaaagacaa aaccagtaca     2040

gtggaagcct gcctgcccct tgaactgact aaaaatgaga gttgtttaaa ttcacgcgaa     2100

accagcttca ttactaacgg aagctgctta gcatcgcgga aaaccagttt tatgatggcc     2160

ctttgccttt catctattta cgaggacctt aaaatgtatc aagttgaatt taagactatg     2220

aacgcgaaac tgctaatgga tcccaagcga caaatctttc ttgatcaaaa tatgttggct     2280

gttattgatg aactgatgca agccctgaat tttaactcag aaaccgtacc tcagaaatcg     2340

agtttagaag aacccgattt ctacaaaact aaaatcaagt tgtgtatcct tttacatgcc     2400

ttccggattc gggccgtcac tattgatcgc gtgatgtcgt acttgaatgc ctcctaaaaa     2460

taaaacgaaa ggctcagtcg aaagactggg cctttcgttt tatctgttgg ttccttatca     2520

tctggcgaat cggacccaca agagcactg                                       2549


<210> 967
<211> 1270
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet.phoA-IL15

<400> 967
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaagatca actcaagata aggaggatcc atgaagcaat      780

ctacgatcgc actagcgtta ctgccgttat tgtttactcc tgtgactaag gctaattggg      840

ttaatgttat atctgatttg aaaaaaatag aggatctgat tcaatcaatg cacatagatg      900

cgactctgta tactgagagc gatgtgcacc cgagttgcaa agttactgct atgaaatgtt      960

ttctgctgga gctgcaagtt atctctctgg agagtggtga tgcgtctatt cacgatactg     1020

ttgagaatct gattattctg gctaataact cgctgtcaag taatgggaat gttacggaat     1080

ctggctgtaa ggagtgtgaa gaattagaag aaaaaaatat taaagagttt ctgcagagtt     1140

ttgtgcacat tgttcagatg tttatcaata ctagctgaaa ataaaacgaa aggctcagtc     1200

gaaagactgg gcctttcgtt ttatctgttg gttccttatc atctggcgaa tcggacccac     1260

aagagcactg                                                            1270


<210> 968
<211> 1309
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet.phoA-GMCSF

<400> 968
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaagaaag caacaacata gggggaaaga atgaagcaat      780

ctacgatcgc gttggcctta ctgcccctgt tattcacacc cgtgaccaaa gcggcaccgg      840

cccgcagccc atcaccgtca actcaacctt gggaacatgt aaatgctatt caagaagctc      900

gccgcctgtt gaatttgagt cgcgatactg cagcagagat gaatgagact gtagaggtga      960

tttcagaaat gtttgacctg caggagccga cttgtttgca aactcgcctg gagctgtaca     1020

aacaaggcct gcgtggctcg ctgactaaac tgaaaggtcc tctgacgatg atggcttctc     1080

attataaaca acactgcccg cctactccgg agacgtcttg cgcgacccag ataattactt     1140

ttgaatcttt taaagagaat ctgaaagact ttctgctggt tatcccgttt gattgttggg     1200

aaccggttca agaataaaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt     1260

tatctgttgg ttccttatca tctggcgaat cggacccaca agagcactg                 1309


<210> 969
<211> 1459
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-phoA-TNFa

<400> 969
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaacacaa cacagaaagg agggctgtcc atgaaacaat      780

caacgatcgc tctggctctg cttccgctgc tctttactcc agttactaaa gcgggtccgc      840

agagggaaga attcccgcgc gatttgagcc tgatttcacc tcttgctcag gctgtccgct      900

cctcttcgcg taccccctcg gataaacctg tcgcgcacgt ggttgcgaac ccgcaagcgg      960

aagggcagct gcaatggtta aaccgccggg ctaatgcact gctggctaat ggagttgagt     1020

tacgcgacaa ccaacttgtc gttccttcgg aagggctgta tctgatctat tcacaggttc     1080

tctttaaagg gcagggttgc ccatcaaccc acgtgctcct gacacacacg atcagtcgta     1140

tcgcggtatc ctatcagacg aaagttaacc tcctgtcagc gattaaatcg ccgtgtcaga     1200

gagaaactcc agagggtgcg gaagctaaac cgtggtatga acctatttat cttggtggag     1260

ttttccagtt ggaaaaaggt gatagactgt cggcagagat caatcgccct gattacctgg     1320

atttcgctga gtcgggtcag gtttatttcg gaattattgc actgtgaaaa taaaacgaaa     1380

ggctcagtcg aaagactggg cctttcgttt tatctgttgg ttccttatca tctggcgaat     1440

cggacccaca agagcactg                                                  1459


<210> 970
<211> 1342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-phoA-IFNg

<400> 970
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaacacca ccaccacgag gaggtaaaaa atgaagcaat      780

ctacgatagc actggcgttg ctgccgctgc tgttcacccc ggttaccaag gcgcaggatc      840

cttacgttaa agaagcagag aatctgaaaa aatactttaa tgcaggccac agcgatgtgg      900

cagataatgg cacgttattc ctgggcattc tgaaaaattg gaaagaagaa tctgaccgga      960

agatcatgca atctcagatc gtatcatttt atttcaagtt gtttaaaaac ttcaaggatg     1020

accagtcgat tcaaaaatca gtggaaacga tcaaagaaga tatgaacgtt aagttcttca     1080

actcaaataa aaaaaaacgc gatgatttcg aaaaactgac taattattcg gtaactgatt     1140

tgaatgttca gcgcaaggcg attcatgaat tgattcaggt tatggcagaa ctgtcgccag     1200

cggcaaaaac gggtaaacga aaacgttctc agatgttgtt tcgtggttga aaataaaacg     1260

aaaggctcag tcgaaagact gggcctttcg ttttatctgt tggttcctta tcatctggcg     1320

aatcggaccc acaagagcac tg                                              1342


<210> 971

<400> 971
000


<210> 972

<400> 972
000


<210> 973

<400> 973
000


<210> 974

<400> 974
000


<210> 975
<211> 5100
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> ptet-J43scFv-V5-HIS (

<400> 975
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaagtga aaggaggtaa attatgcaat tggaagttcg cctgttggag     1080

agcggtggtg gacttgtgaa acccgaggga agccttaaac tttcgtgcgt tgctagtggg     1140

ttcacatttt cagactattt catgtcctgg gtccgtcaag ccccgggaaa aggacttgaa     1200

tgggttgccc atatttacac caagagctat aactatgcca catactattc tggaagcgtt     1260

aaaggtcgtt ttaccatttc gcgtgacgac agccgttcta tggtgtattt gcagatgaat     1320

aaccttcgta cagaagatac ggctacttac tactgtactc gcgatggatc aggctatccc     1380

agtttagatt tctggggaca gggtactcag gttactgttt caagcggtgg aggcggctct     1440

ggcggtggtg ggagtggagg cggtggcagt tacgagctga cgcagccacc ctcggcaagt     1500

gtaaacgtgg gcgaaacggt gaaaattact tgttcggggg atcaactgcc caaatacttc     1560

gccgattggt ttcatcaacg ttccgatcag actattttac aagtgattta tgatgataac     1620

aaacgtccgt caggaatccc agagcgtatc agcggatcga gcagcggaac aacagcaact     1680

ttgaccatcc gcgatgtccg tgccgaagac gagggggact actattgttt ctctggatac     1740

gtggactcag acagcaagct gtatgttttt ggctcaggaa cacaactgac cgtactgggc     1800

aagggcgagc tcaattcgaa gcttgaaggt aagcctatcc ctaaccctct cctcggcctc     1860

gattctacgc gtaccggtca tcatcaccat caccattgag catgcggtct caggaggaag     1920

ggcgaattct gcagatatcc atcacactgg cggccgctcg agcatgcatc tagagggccc     1980

aattcgccct atagtgagtc gtattacaat tcactggccg tcgttttaca acgtcgtgac     2040

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     2100

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctatac     2160

gtacggcagt ttaaggttta cacctataaa agagagagcc gttatcgtct gtttgtggat     2220

gtacagagtg atattattga cacgccgggg cgacggatgg tgatccccct ggccagtgca     2280

cgtctgctgt cagataaagt ctcccgtgaa ctttacccgg tggtgcatat cggggatgaa     2340

agctggcgca tgatgaccac cgatatggcc agtgtgccgg tctccgttat cggggaagaa     2400

gtggctgatc tcagccaccg cgaaaatgac atcaaaaacg ccattaacct gatgttctgg     2460

ggaatataaa tgtcaggcat gagattatca aaaaggatct tcacctagat ccttttcacg     2520

tagaaagcca gtccgcagaa acggtgctga ccccggatga atgtcagcta ctgggctatc     2580

tggacaaggg aaaacgcaag cgcaaagaga aagcaggtag cttgcagtgg gcttacatgg     2640

cgatagctag actgggcggt tttatggaca gcaagcgaac cggaattgcc agctggggcg     2700

ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctc gccgccaagg     2760

atctgatggc gcaggggatc aagctctgat caagagacag gatgaggatc gtttcgcatg     2820

attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc     2880

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     2940

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcaa     3000

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     3060

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     3120

ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     3180

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc     3240

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag     3300

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgagcat gcccgacggc     3360

gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc     3420

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata     3480

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc     3540

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac     3600

gagttcttct gaattattaa cgcttacaat ttcctgatgc ggtattttct ccttacgcat     3660

ctgtgcggta tttcacaccg catacaggtg gcacttttcg gggaaatgtg cgcggaaccc     3720

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     3780

gataaatgct tcaataatag cacgtgagga gggccaccat ggccaagttg accagtgccg     3840

ttccggtgct caccgcgcgc gacgtcgccg gagcggtcga gttctggacc gaccggctcg     3900

ggttctcccg ggacttcgtg gaggacgact tcgccggtgt ggtccgggac gacgtgaccc     3960

tgttcatcag cgcggtccag gaccaggtgg tgccggacaa caccctggcc tgggtgtggg     4020

tgcgcggcct ggacgagctg tacgccgagt ggtcggaggt cgtgtccacg aacttccggg     4080

acgcctccgg gccggccatg accgagatcg gcgagcagcc gtgggggcgg gagttcgccc     4140

tgcgcgaccc ggccggcaac tgcgtgcact tcgtggccga ggagcaggac tgacacgtgc     4200

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga     4260

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca     4320

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac     4380

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg     4440

taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag     4500

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac     4560

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     4620

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     4680

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     4740

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     4800

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     4860

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     4920

acgccagcaa cgcggccttt ttacggttcc tgggcttttg ctggcctttt gctcacatgt     4980

tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg     5040

ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag     5100


<210> 976
<211> 846
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> J43-Anti-PD1-scFv-V5-HIS

<400> 976
atgcaattgg aagttcgcct gttggagagc ggtggtggac ttgtgaaacc cgagggaagc       60

cttaaacttt cgtgcgttgc tagtgggttc acattttcag actatttcat gtcctgggtc      120

cgtcaagccc cgggaaaagg acttgaatgg gttgcccata tttacaccaa gagctataac      180

tatgccacat actattctgg aagcgttaaa ggtcgtttta ccatttcgcg tgacgacagc      240

cgttctatgg tgtatttgca gatgaataac cttcgtacag aagatacggc tacttactac      300

tgtactcgcg atggatcagg ctatcccagt ttagatttct ggggacaggg tactcaggtt      360

actgtttcaa gcggtggagg cggctctggc ggtggtggga gtggaggcgg tggcagttac      420

gagctgacgc agccaccctc ggcaagtgta aacgtgggcg aaacggtgaa aattacttgt      480

tcgggggatc aactgcccaa atacttcgcc gattggtttc atcaacgttc cgatcagact      540

attttacaag tgatttatga tgataacaaa cgtccgtcag gaatcccaga gcgtatcagc      600

ggatcgagca gcggaacaac agcaactttg accatccgcg atgtccgtgc cgaagacgag      660

ggggactact attgtttctc tggatacgtg gactcagaca gcaagctgta tgtttttggc      720

tcaggaacac aactgaccgt actgggcaag ggcgagctca attcgaagct tgaaggtaag      780

cctatcccta accctctcct cggcctcgat tctacgcgta ccggtcatca tcaccatcac      840

cattga                                                                 846


<210> 977
<211> 363
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> scFvHeavy chain

<400> 977
gaagttcgcc tgttggagag cggtggtgga cttgtgaaac ccgagggaag ccttaaactt       60

tcgtgcgttg ctagtgggtt cacattttca gactatttca tgtcctgggt ccgtcaagcc      120

ccgggaaaag gacttgaatg ggttgcccat atttacacca agagctataa ctatgccaca      180

tactattctg gaagcgttaa aggtcgtttt accatttcgc gtgacgacag ccgttctatg      240

gtgtatttgc agatgaataa ccttcgtaca gaagatacgg ctacttacta ctgtactcgc      300

gatggatcag gctatcccag tttagatttc tggggacagg gtactcaggt tactgtttca      360

agc                                                                    363


<210> 978
<211> 330
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> scFvLight chain

<400> 978
tacgagctga cgcagccacc ctcggcaagt gtaaacgtgg gcgaaacggt gaaaattact       60

tgttcggggg atcaactgcc caaatacttc gccgattggt ttcatcaacg ttccgatcag      120

actattttac aagtgattta tgatgataac aaacgtccgt caggaatccc agagcgtatc      180

agcggatcga gcagcggaac aacagcaact ttgaccatcc gcgatgtccg tgccgaagac      240

gagggggact actattgttt ctctggatac gtggactcag acagcaagct gtatgttttt      300

ggctcaggaa cacaactgac cgtactgggc                                       330


<210> 979
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> scFvLinker

<400> 979
ggtggaggcg gctctggcgg tggtgggagt ggaggcggtg gcagt                       45


<210> 980
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> J43-Anti-PD1-scFV polypeptide sequence

<400> 980
Met Gln Leu Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Lys 
1               5                   10                  15      


Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
            20                  25                  30          


Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr Tyr 
    50                  55                  60                  


Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
65                  70                  75                  80  


Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu Asp 
            100                 105                 110         


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile Thr Cys 
145                 150                 155                 160 


Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His Gln Arg 
                165                 170                 175     


Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys Arg Pro 
            180                 185                 190         


Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr Thr Ala 
        195                 200                 205             


Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp Tyr Tyr 
    210                 215                 220                 


Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val Phe Gly 
225                 230                 235                 240 


Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn Ser Lys 
                245                 250                 255     


Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
            260                 265                 270         


Arg Thr Gly His His His His His His 
        275                 280     


<210> 981
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-phoA-FLAG-J43-scFv-V5-HIS

<400> 981
ttaagaccca ctttcacatt taagttgttt ttctaatccg cagatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acataattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaaaggag gtaaattatg      720

actagtaaac aatcgaccat cgcattggcg ctgcttcctc tattgttcac accggtgaca      780

aaggcagtcg actataagga tgacgacgac aagcaattgg gcggtggcat ggaagttcgc      840

ctgttggaga gcggtggagg acttgtgaag cccgagggaa gccttaaact ttcgtgcgtt      900

gctagtgggt tcacattttc agactatttc atgtcctggg tccgtcaagc cccgggaaaa      960

ggacttgaat gggttgccca tatttacacc aagagctata actatgccac atactattct     1020

ggaagcgtta aaggtcgttt taccatttcg cgtgacgaca gccgttctat ggtgtatttg     1080

cagatgaata accttcgtac agaagatacg gctacttact actgtactcg cgatggatca     1140

ggctatccca gtttagattt ctggggacag ggtactcagg ttactgtttc aagcggtgga     1200

ggcggctctg gcggtggtgg gagtggaggc ggtggcagtt acgagctgac gcagccgccc     1260

tcggcaagtg taaacgtggg cgaaacggtg aaaattactt gttcggggga tcaactgccc     1320

aaatacttcg ccgattggtt tcatcaacgt tccgatcaga ctattttaca agtgatttat     1380

gatgataaca aacgtccgtc aggaatccca gagcgtatca gcggatcgag cagcggaaca     1440

acagcaactt tgaccatccg cgatgtccgt gccgaagacg agggggacta ctattgtttc     1500

tctggatacg tggactcaga cagcaagctg tatgtttttg gctcaggaac acaactgacc     1560

gtactgggca agggcgagct caattcgaag cttgaaggta agcctatccc taaccctctc     1620

ctcggactcg attctacggg atccggtcat catcaccatc accattga                  1668


<210> 982
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> phoA-FLAG-J43-scFv-V5-HIS

<400> 982
Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly 
            20                  25                  30          


Gly Gly Met Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Lys 
        35                  40                  45              


Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
    50                  55                  60                  


Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
65                  70                  75                  80  


Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr Tyr 
                85                  90                  95      


Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
            100                 105                 110         


Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr 
        115                 120                 125             


Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu Asp 
    130                 135                 140                 


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu Thr Gln 
                165                 170                 175     


Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile Thr Cys 
            180                 185                 190         


Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His Gln Arg 
        195                 200                 205             


Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys Arg Pro 
    210                 215                 220                 


Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr Thr Ala 
225                 230                 235                 240 


Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp Tyr Tyr 
                245                 250                 255     


Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val Phe Gly 
            260                 265                 270         


Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn Ser Lys 
        275                 280                 285             


Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
    290                 295                 300                 


Gly Ser Gly His His His His His His 
305                 310             


<210> 983
<211> 1674
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-ompF-FLAG-J43-scFv-V5-HIS

<400> 983
ttaagaccca ctttcacatt taagttgttt ttctaatccg cagatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acatcattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaaaggag gtaaattatg      720

actagtatga tgaagcgtaa catcttagcc gttattgtcc ccgcattgct tgtggccggg      780

acggctaacg cagtcgacta taaggatgac gacgacaagc aattgggcgg tggcatggaa      840

gttcgcctgt tggagagcgg tggaggactt gtgaagcccg agggaagcct taaactttcg      900

tgcgttgcta gtgggttcac attttcagac tatttcatgt cctgggtccg tcaagccccg      960

ggaaaaggac ttgaatgggt tgcccatatt tacaccaaga gctataacta tgccacatac     1020

tattctggaa gcgttaaagg tcgttttacc atttcgcgtg acgacagccg ttctatggtg     1080

tatttgcaga tgaataacct tcgtacagaa gatacggcta cttactactg tactcgcgat     1140

ggatcaggct atcccagttt agatttctgg ggacagggta ctcaggttac tgtttcaagc     1200

ggtggaggcg gctctggcgg tggtgggagt ggaggcggtg gcagttacga gctgacgcag     1260

ccgccctcgg caagtgtaaa cgtgggcgaa acggtgaaaa ttacttgttc gggggatcaa     1320

ctgcccaaat acttcgccga ttggtttcat caacgttccg atcagactat tttacaagtg     1380

atttatgatg ataacaaacg tccgtcagga atcccagagc gtatcagcgg atcgagcagc     1440

ggaacaacag caactttgac catccgcgat gtccgtgccg aagacgaggg ggactactat     1500

tgtttctctg gatacgtgga ctcagacagc aagctgtatg tttttggctc aggaacacaa     1560

ctgaccgtac tgggcaaggg cgagctcaat tcgaagcttg aaggtaagcc tatccctaac     1620

cctctcctcg gactcgattc tacgggatcc ggtcatcatc accatcacca ttga           1674


<210> 984
<211> 315
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> ompF-FLAG-J43-scFv-V5-HIS

<400> 984
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln 
            20                  25                  30          


Leu Gly Gly Gly Met Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu 
        35                  40                  45              


Val Lys Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe 
    50                  55                  60                  


Thr Phe Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
65                  70                  75                  80  


Gly Leu Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala 
                85                  90                  95      


Thr Tyr Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            100                 105                 110         


Asp Ser Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu 
        115                 120                 125             


Asp Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser 
    130                 135                 140                 


Leu Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu 
                165                 170                 175     


Thr Gln Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile 
            180                 185                 190         


Thr Cys Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His 
        195                 200                 205             


Gln Arg Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys 
    210                 215                 220                 


Arg Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr 
225                 230                 235                 240 


Thr Ala Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp 
                245                 250                 255     


Tyr Tyr Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val 
            260                 265                 270         


Phe Gly Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn 
        275                 280                 285             


Ser Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
    290                 295                 300                 


Ser Thr Gly Ser Gly His His His His His His 
305                 310                 315 


<210> 985
<211> 1668
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Ptet-PelB-FLAG-J43-scFv-V5-HIS

<400> 985
ttaagaccca ctttcacatt taagttgttt ttctaatccg cagatgatca attcaaggcc       60

gaataagaag gctggctctg caccttggtg atcaaataat tcgatagctt gtcgtaataa      120

tggcggcata ctatcagtag taggtgtttc cctttcttct ttagcgactt gatgctcttg      180

atcttccaat acgcaaccta aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt      240

ctctagtgaa aaaccttgtt ggcataaaaa ggctaattga ttttcgagag tttcatactg      300

tttttctgta ggccgtgtac ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc      360

acatctaaaa cttttagcgt tattacgtaa aaaatcttgc cagctttccc cttctaaagg      420

gcaaaagtga gtatggtgcc tatctaacat ctcaatggct aaggcgtcga gcaaagcccg      480

cttatttttt acatgccaat acaatgtagg ctgctctaca cctagcttct gggcgagttt      540

acgggttgtt aaaccttcga ttccgacctc attaagcagc tctaatgcgc tgttaatcac      600

tttactttta tctaatctag acatcattaa ttcctaattt ttgttgacac tctatcattg      660

atagagttat tttaccactc cctatcagtg atagagaaaa gtgaaaggag gtaaattatg      720

actagtaaat atcttcttcc aacggctgct gctggtttat tgcttcttgc cgcccagcct      780

gcgatggctg tcgactataa ggatgacgac gacaagcaat tgggcggtgg catggaagtt      840

cgcctgttgg agagcggtgg aggacttgtg aagcccgagg gaagccttaa actttcgtgc      900

gttgctagtg ggttcacatt ttcagactat ttcatgtcct gggtccgtca agccccggga      960

aaaggacttg aatgggttgc ccatatttac accaagagct ataactatgc cacatactat     1020

tctggaagcg ttaaaggtcg ttttaccatt tcgcgtgacg acagccgttc tatggtgtat     1080

ttgcagatga ataaccttcg tacagaagat acggctactt actactgtac tcgcgatgga     1140

tcaggctatc ccagtttaga tttctgggga cagggtactc aggttactgt ttcaagcggt     1200

ggaggcggct ctggcggtgg tgggagtgga ggcggtggca gttacgagct gacgcagccg     1260

ccctcggcaa gtgtaaacgt gggcgaaacg gtgaaaatta cttgttcggg ggatcaactg     1320

cccaaatact tcgccgattg gtttcatcaa cgttccgatc agactatttt acaagtgatt     1380

tatgatgata acaaacgtcc gtcaggaatc ccagagcgta tcagcggatc gagcagcgga     1440

acaacagcaa ctttgaccat ccgcgatgtc cgtgccgaag acgaggggga ctactattgt     1500

ttctctggat acgtggactc agacagcaag ctgtatgttt ttggctcagg aacacaactg     1560

accgtactgg gcaagggcga gctcaattcg aagcttgaag gtaagcctat ccctaaccct     1620

ctcctcggac tcgattctac gggatccggt catcatcacc atcaccat                  1668


<210> 986
<211> 314
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> PelB-FLAG-J43-scFv-V5-HIS

<400> 986
Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala 
1               5                   10                  15      


Gln Pro Ala Met Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Met Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val 
        35                  40                  45              


Lys Pro Glu Gly Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr 
    50                  55                  60                  


Phe Ser Asp Tyr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala His Ile Tyr Thr Lys Ser Tyr Asn Tyr Ala Thr 
                85                  90                  95      


Tyr Tyr Ser Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
            100                 105                 110         


Ser Arg Ser Met Val Tyr Leu Gln Met Asn Asn Leu Arg Thr Glu Asp 
        115                 120                 125             


Thr Ala Thr Tyr Tyr Cys Thr Arg Asp Gly Ser Gly Tyr Pro Ser Leu 
    130                 135                 140                 


Asp Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Tyr Glu Leu Thr 
                165                 170                 175     


Gln Pro Pro Ser Ala Ser Val Asn Val Gly Glu Thr Val Lys Ile Thr 
            180                 185                 190         


Cys Ser Gly Asp Gln Leu Pro Lys Tyr Phe Ala Asp Trp Phe His Gln 
        195                 200                 205             


Arg Ser Asp Gln Thr Ile Leu Gln Val Ile Tyr Asp Asp Asn Lys Arg 
    210                 215                 220                 


Pro Ser Gly Ile Pro Glu Arg Ile Ser Gly Ser Ser Ser Gly Thr Thr 
225                 230                 235                 240 


Ala Thr Leu Thr Ile Arg Asp Val Arg Ala Glu Asp Glu Gly Asp Tyr 
                245                 250                 255     


Tyr Cys Phe Ser Gly Tyr Val Asp Ser Asp Ser Lys Leu Tyr Val Phe 
            260                 265                 270         


Gly Ser Gly Thr Gln Leu Thr Val Leu Gly Lys Gly Glu Leu Asn Ser 
        275                 280                 285             


Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
    290                 295                 300                 


Thr Gly Ser Gly His His His His His His 
305                 310                 


<210> 987
<211> 5708
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> p15A-Kan-ptet-Invasin-FLAG-J43scFv-V5-HIS

<400> 987
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaaaggaggt aaattatgac     1620

tagtatggtt ttccaaccca tcagcgaatt tttgctgatt cgtaacgctg ggatgtccat     1680

gtattttaac aagatcattt cttttaacat catttcacgt atcgttattt gcatttttct     1740

tatctgtggt atgttcatgg ccggtgcatc tgaaaagtat gatgcaaacg caccccaaca     1800

ggtgcagcca tactcggttt catcatcagc gttcgagaat ctgcacccca ataacgagat     1860

ggagtcgagt atcaaccctt ttagtgcttc ggacaccgag cgtaatgcag ctatcatcga     1920

tcgtgctaac aaggaacaag aaacggaagc agtcaacaaa atgatctcca ctggcgctcg     1980

tttagctgcc agcggtcgcg cgtccgatgt ggcgcacagt atggtagggg atgcggtcaa     2040

ccaggagatt aaacaatggc tgaatcgctt cggcactgct caagtgaatt taaattttga     2100

caagaacttc tcgttaaagg agtcttcgct tgactggttg gccccatggt acgattcggc     2160

gtcattcctt ttcttttctc agttgggcat ccgtaacaag gacagtcgta atacacttaa     2220

ccttggtgtt ggcattcgca cattagaaaa tggttggttg tatggcctga acacctttta     2280

cgacaatgac ttaacgggac acaatcaccg tatcgggctg ggcgccgagg cgtggactga     2340

ctacttgcag ttagccgcga atgggtactt ccgtcttaat ggttggcact cttcccgtga     2400

cttcagcgac tacaaagaac gccctgctac cgggggagat ttgcgtgcga atgcgtacct     2460

gcccgctctt ccgcaacttg gcgggaagtt aatgtatgag cagtatactg gggaacgcgt     2520

ggctctgttc ggaaaggaca acctgcagcg caacccatac gctgtcactg cgggtatcaa     2580

ctatacgcca gttccgttgc tgacggtcgg cgtggatcaa cgtatgggga agtcgagtaa     2640

acatgaaacg caatggaatt tacaaatgaa ctatcgctta ggggagagtt tccaaagtca     2700

gcttagccct tcggcggtcg cagggactcg tttgcttgct gagtcccgct acaacctggt     2760

tgatcgcaat aacaatatcg tactggaata ccagaaacaa caagtggtta agctgacgtt     2820

gagccctgcg accatcagtg gattgcccgg acaagtttac caggtaaatg cccaggtcca     2880

gggggcctct gcggttcgcg aaattgtctg gtcagacgca gaattaatcg ctgcaggagg     2940

caccttaacg ccactttcca ctacacaatt caatttagtc cttcccccat acaaacgtac     3000

cgcccaggta tcgcgcgtaa ctgatgactt aactgctaat ttttattcac tgtcggcgtt     3060

agcagttgac catcaaggca accgtagtaa ttccttcaca ttatctgtaa cggtgcagca     3120

gccgcaactg acgcttaccg cagcggtcat tggtgatggg gccccagcta atgggaaaac     3180

cgcaatcact gtcgagttca cagttgcaga ttttgaaggc aagccgctgg cgggtcagga     3240

ggttgtgatt acgactaata acggtgctct tcctaataag attactgaaa agactgacgc     3300

taacggcgtt gcccgcattg cccttacgaa cacaaccgat ggggtcacgg tagttaccgc     3360

agaggtcgag gggcaacgcc aatccgttga cacgcacttc gttaagggta ctatcgcggc     3420

cgataaaagc acgctggccg cggtcgacta taaggatgac gacgacaagc aattggaagt     3480

tcgcctgttg gagagcggtg gtggacttgt gaaacccgag ggaagcctta aactttcgtg     3540

cgttgctagt gggttcacat tttcagacta tttcatgtcc tgggtccgtc aagccccggg     3600

aaaaggactt gaatgggttg cccatattta caccaagagc tataactatg ccacatacta     3660

ttctggaagc gttaaaggtc gttttaccat ttcgcgtgac gacagccgtt ctatggtgta     3720

tttgcagatg aataaccttc gtacagaaga tacggctact tactactgta ctcgcgatgg     3780

atcaggctat cccagtttag atttctgggg acagggtact caggttactg tttcaagcgg     3840

tggaggcggc tctggcggtg gtgggagtgg aggcggtggc agttacgagc tgacgcagcc     3900

accctcggca agtgtaaacg tgggcgaaac ggtgaaaatt acttgttcgg gggatcaact     3960

gcccaaatac ttcgccgatt ggtttcatca acgttccgat cagactattt tacaagtgat     4020

ttatgatgat aacaaacgtc cgtcaggaat cccagagcgt atcagcggat cgagcagcgg     4080

aacaacagca actttgacca tccgcgatgt ccgtgccgaa gacgaggggg actactattg     4140

tttctctgga tacgtggact cagacagcaa gctgtatgtt tttggctcag gaacacaact     4200

gaccgtactg ggcaagggcg agctcaattc gaagcttgaa ggtaagccta tccctaaccc     4260

tctcctcggc ctcgattcta cgcgtaccgg tcatcatcac catcaccatt gagcatgcta     4320

atcagccgtg gaattcgcaa cgtaaaaaaa cccgccccgg cgggtttttt tataccggtc     4380

tcaggaggaa cgattggtaa acccggtgaa cgcatgagaa agcccccgga agatcacctt     4440

ccgggggctt ttttattgcg cggaccaaaa cgaaaaaaga cgctcgaaag cgtctctttt     4500

ctggaatttg gtaccgaggc gtaatgctct gccagtgtta caaccaatta accaattctg     4560

attagaaaaa ctcatcgagc atcaaatgaa actgcaattt attcatatca ggattatcaa     4620

taccatattt ttgaaaaagc cgtttctgta atgaaggaga aaactcaccg aggcagttcc     4680

ataggatggc aagatcctgg tatcggtctg cgattccgac tcgtccaaca tcaatacaac     4740

ctattaattt cccctcgtca aaaataaggt tatcaagtga gaaatcacca tgagtgacga     4800

ctgaatccgg tgagaatggc aaaagcttat gcatttcttt ccagacttgt tcaacaggcc     4860

agccattacg ctcgtcatca aaatcactcg catcaaccaa accgttattc attcgtgatt     4920

gcgcctgagc gagacgaaat acgcgatcgc tgttaaaagg acaattacaa acaggaatcg     4980

aatgcaaccg gcgcaggaac actgccagcg catcaacaat attttcacct gaatcaggat     5040

attcttctaa tacctggaat gctgttttcc cggggatcgc agtggtgagt aaccatgcat     5100

catcaggagt acggataaaa tgcttgatgg tcggaagagg cataaattcc gtcagccagt     5160

ttagtctgac catctcatct gtaacatcat tggcaacgct acctttgcca tgtttcagaa     5220

acaactctgg cgcatcgggc ttcccataca atcgatagat tgtcgcacct gattgcccga     5280

cattatcgcg agcccattta tacccatata aatcagcatc catgttggaa tttaatcgcg     5340

gcctcgagca agacgtttcc cgttgaatat ggctcataac accccttgta ttactgttta     5400

tgtaagcaga cagttttatt gttcatgatg atatattttt atcttgtgca atgtaacatc     5460

agagattttg agacacaacg tggctttgtt gaataaatcg aacttttgct gagttgaagg     5520

atcagatcac gcatcttccc gacaacgcag accgttccgt ggcaaagcaa aagttcaaaa     5580

tcaccaactg gtccacctac aacaaagctc tcatcaaccg tggctccctc actttctggc     5640

tggatgatgg ggcgattcag gcctggtatg agtcagcaac accttcttca cgaggcagac     5700

ctcagcgc                                                              5708


<210> 988
<211> 4282
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> p15A-Kan-ptet-LppOmpA-FLAG-J43scFv-V5-HIS

<400> 988
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaaaggaggt aaattatgac     1620

tagtaaagca acaaaacttg tgttaggcgc ggttatactt ggctccaccc tgcttgcagg     1680

ttgctcgtct aacgcgaaga tcgaccaggg tatcaatcct tacgtcgggt ttgaaatggg     1740

atacgattgg ttgggacgta tgccttataa gggaagtgtt gaaaacggcg cttataaggc     1800

gcagggagta cagttaacgg ccaagcttgg gtaccccata acagacgatt tagatattta     1860

tacccgttta ggaggaatgg tttggagagc cgacacgaag tctaatgtat atggtaagaa     1920

ccacgacacg ggagtatccc ccgtctttgc agggggagtg gaatatgcta tcacaccaga     1980

gatcgctacc cgtttggaat atcaatggac gaataatata ggcgacgccc atacgatagg     2040

aacgcggccc gacaacggca tccctggggt cgactataag gatgacgacg acaagcaatt     2100

ggaagttcgc ctgttggaga gcggtggtgg acttgtgaaa cccgagggaa gccttaaact     2160

ttcgtgcgtt gctagtgggt tcacattttc agactatttc atgtcctggg tccgtcaagc     2220

cccgggaaaa ggacttgaat gggttgccca tatttacacc aagagctata actatgccac     2280

atactattct ggaagcgtta aaggtcgttt taccatttcg cgtgacgaca gccgttctat     2340

ggtgtatttg cagatgaata accttcgtac agaagatacg gctacttact actgtactcg     2400

cgatggatca ggctatccca gtttagattt ctggggacag ggtactcagg ttactgtttc     2460

aagcggtgga ggcggctctg gcggtggtgg gagtggaggc ggtggcagtt acgagctgac     2520

gcagccaccc tcggcaagtg taaacgtggg cgaaacggtg aaaattactt gttcggggga     2580

tcaactgccc aaatacttcg ccgattggtt tcatcaacgt tccgatcaga ctattttaca     2640

agtgatttat gatgataaca aacgtccgtc aggaatccca gagcgtatca gcggatcgag     2700

cagcggaaca acagcaactt tgaccatccg cgatgtccgt gccgaagacg agggggacta     2760

ctattgtttc tctggatacg tggactcaga cagcaagctg tatgtttttg gctcaggaac     2820

acaactgacc gtactgggca agggcgagct caattcgaag cttgaaggta agcctatccc     2880

taaccctctc ctcggcctcg attctacgcg taccggtcat catcaccatc accattgagc     2940

atgcgaattc ggtctcagga ggaacgattg gtaaacccgg tgaacgcatg agaaagcccc     3000

cggaagatca ccttccgggg gcttttttat tgcgcggacc aaaacgaaaa aagacgctcg     3060

aaagcgtctc ttttctggaa tttggtaccg aggcgtaatg ctctgccagt gttacaacca     3120

attaaccaat tctgattaga aaaactcatc gagcatcaaa tgaaactgca atttattcat     3180

atcaggatta tcaataccat atttttgaaa aagccgtttc tgtaatgaag gagaaaactc     3240

accgaggcag ttccatagga tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc     3300

aacatcaata caacctatta atttcccctc gtcaaaaata aggttatcaa gtgagaaatc     3360

accatgagtg acgactgaat ccggtgagaa tggcaaaagc ttatgcattt ctttccagac     3420

ttgttcaaca ggccagccat tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt     3480

attcattcgt gattgcgcct gagcgagacg aaatacgcga tcgctgttaa aaggacaatt     3540

acaaacagga atcgaatgca accggcgcag gaacactgcc agcgcatcaa caatattttc     3600

acctgaatca ggatattctt ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt     3660

gagtaaccat gcatcatcag gagtacggat aaaatgcttg atggtcggaa gaggcataaa     3720

ttccgtcagc cagtttagtc tgaccatctc atctgtaaca tcattggcaa cgctaccttt     3780

gccatgtttc agaaacaact ctggcgcatc gggcttccca tacaatcgat agattgtcgc     3840

acctgattgc ccgacattat cgcgagccca tttataccca tataaatcag catccatgtt     3900

ggaatttaat cgcggcctcg agcaagacgt ttcccgttga atatggctca taacacccct     3960

tgtattactg tttatgtaag cagacagttt tattgttcat gatgatatat ttttatcttg     4020

tgcaatgtaa catcagagat tttgagacac aacgtggctt tgttgaataa atcgaacttt     4080

tgctgagttg aaggatcaga tcacgcatct tcccgacaac gcagaccgtt ccgtggcaaa     4140

gcaaaagttc aaaatcacca actggtccac ctacaacaaa gctctcatca accgtggctc     4200

cctcactttc tggctggatg atggggcgat tcaggcctgg tatgagtcag caacaccttc     4260

ttcacgaggc agacctcagc gc                                              4282


<210> 989
<211> 5864
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> p15A-Kan-ptet-IntiminN-FLAG-J43scFv-V5-HIS

<400> 989
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaaaggaggt aaattatgac     1620

tagtattacg catggctgtt atacccgtac gcgtcataaa cacaagttga agaaaactct     1680

gatcatgtta tccgctggac ttggactttt tttttacgtg aatcagaact ctttcgctaa     1740

tggggaaaat tattttaaac tgggatcaga cagcaaatta cttacgcatg actcatacca     1800

gaatcgtctg ttttatacgc tgaaaactgg tgaaaccgtt gcagatttaa gtaaaagtca     1860

ggacattaac ctgtcaacta tttggtcact taataaacac ttatattcga gcgaatcgga     1920

aatgatgaaa gctgcaccgg ggcaacaaat catcttgccc ctgaagaaat tgccctttga     1980

atactccgct ttgcccttgc tgggctcggc tcctctggta gccgccggag gcgttgccgg     2040

tcacactaat aagctgacaa aaatgtcacc cgacgtgacg aagagcaaca tgacggatga     2100

taaggcttta aattacgcag ctcagcaagc ggcctcgttg ggaagtcagt tacagagtcg     2160

ttcgttaaat ggtgattatg ctaaggatac cgcattgggt attgccggca accaagcgtc     2220

gagccaactt caggcatggt tgcaacatta cggcactgct gaagtaaatc tgcaatcagg     2280

taataatttt gacggtagtt ccctggattt ccttttacct ttttacgatt cagaaaagat     2340

gttggctttc ggacaggtgg gggcgcgtta catcgattca cgttttaccg ctaacttggg     2400

ggccggtcaa cgcttcttct tacctgccaa tatgttgggc tataatgtat ttatcgacca     2460

ggacttcagt ggtgacaata cacgtctggg aattggtgga gagtattggc gcgattactt     2520

taagtcatct gtaaatggct attttcgcat gagcggttgg catgaaagtt acaacaagaa     2580

agactacgat gagcgccccg cgaacgggtt tgacatccgt tttaatggtt atttgccatc     2640

ttatcccgcc ttgggagcta aattaatcta cgagcaatac tatggagata acgtagcttt     2700

gtttaatagc gacaagttac agtctaatcc aggagcggct acagtgggag ttaattatac     2760

cccaatccca ctggtcacaa tgggaatcga ttatcgccac gggactggta atgaaaacga     2820

tttattatac tccatgcagt ttcgttatca gttcgataag agttggtcgc agcagattga     2880

gcctcaatat gttaacgaat tacgtacctt gtccggcagt cgctacgatc tggtacaacg     2940

caataacaat atcatccttg agtataagaa acaggacatt ctgtctttga acattccaca     3000

tgatattaat ggtaccgagc actcaacaca aaaaattcag ctgattgtga aatcaaagta     3060

tggactggac cgtatcgtgt gggatgatag cgctctgcgc agtcagggtg gacagatcca     3120

gcactcgggt agccagtctg cccaagacta ccaggctatc ctgccagcgt atgtccaagg     3180

gggaagtaac atctacaaag ttacagctcg cgcctattac cgcaacggta attctagtaa     3240

taatgtgcag ttgacaatta cggtgctgtc caatgggcag gtcgtcgatc aggtaggtgt     3300

gacggatttt acagccgata aaacctctgc gaaggcagat aacgcggata ccatcacata     3360

cactgccact gtaaaaaaaa acggtgtcgc gcaggcaaac gttcctgtta gcttcaacat     3420

cgtgtcgggt acagccaccc ttggggccaa ctcggcaaag actgacgcga atggcaaggc     3480

tacagtcacg ttgaaatcct cgacaccagg acaggtcgtt gtgtctgcca agacagcaga     3540

gatgacctcc gcccttaatg catctgctgt tatcttcttc gatcaaacga aggcatctgt     3600

cgactataag gatgacgacg acaagcaatt ggaagttcgc ctgttggaga gcggtggtgg     3660

acttgtgaaa cccgagggaa gccttaaact ttcgtgcgtt gctagtgggt tcacattttc     3720

agactatttc atgtcctggg tccgtcaagc cccgggaaaa ggacttgaat gggttgccca     3780

tatttacacc aagagctata actatgccac atactattct ggaagcgtta aaggtcgttt     3840

taccatttcg cgtgacgaca gccgttctat ggtgtatttg cagatgaata accttcgtac     3900

agaagatacg gctacttact actgtactcg cgatggatca ggctatccca gtttagattt     3960

ctggggacag ggtactcagg ttactgtttc aagcggtgga ggcggctctg gcggtggtgg     4020

gagtggaggc ggtggcagtt acgagctgac gcagccaccc tcggcaagtg taaacgtggg     4080

cgaaacggtg aaaattactt gttcggggga tcaactgccc aaatacttcg ccgattggtt     4140

tcatcaacgt tccgatcaga ctattttaca agtgatttat gatgataaca aacgtccgtc     4200

aggaatccca gagcgtatca gcggatcgag cagcggaaca acagcaactt tgaccatccg     4260

cgatgtccgt gccgaagacg agggggacta ctattgtttc tctggatacg tggactcaga     4320

cagcaagctg tatgtttttg gctcaggaac acaactgacc gtactgggca agggcgagct     4380

caattcgaag cttgaaggta agcctatccc taaccctctc ctcggcctcg attctacgcg     4440

taccggtcat catcaccatc accattgagc atgctaatca gccgtggaat tcgcaacgta     4500

aaaaaacccg ccccggcggg tttttttata ccggtctcag gaggaacgat tggtaaaccc     4560

ggtgaacgca tgagaaagcc cccggaagat caccttccgg gggctttttt attgcgcgga     4620

ccaaaacgaa aaaagacgct cgaaagcgtc tcttttctgg aatttggtac cgaggcgtaa     4680

tgctctgcca gtgttacaac caattaacca attctgatta gaaaaactca tcgagcatca     4740

aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt     4800

tctgtaatga aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc     4860

ggtctgcgat tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa     4920

taaggttatc aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa     4980

gcttatgcat ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat     5040

cactcgcatc aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc     5100

gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg     5160

ccagcgcatc aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg     5220

ttttcccggg gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct     5280

tgatggtcgg aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa     5340

catcattggc aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc     5400

catacaatcg atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc     5460

catataaatc agcatccatg ttggaattta atcgcggcct cgagcaagac gtttcccgtt     5520

gaatatggct cataacaccc cttgtattac tgtttatgta agcagacagt tttattgttc     5580

atgatgatat atttttatct tgtgcaatgt aacatcagag attttgagac acaacgtggc     5640

tttgttgaat aaatcgaact tttgctgagt tgaaggatca gatcacgcat cttcccgaca     5700

acgcagaccg ttccgtggca aagcaaaagt tcaaaatcac caactggtcc acctacaaca     5760

aagctctcat caaccgtggc tccctcactt tctggctgga tgatggggcg attcaggcct     5820

ggtatgagtc agcaacacct tcttcacgag gcagacctca gcgc                      5864


<210> 990
<211> 607
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Invasin display tag

<400> 990
Met Val Phe Gln Pro Ile Ser Glu Phe Leu Leu Ile Arg Asn Ala Gly 
1               5                   10                  15      


Met Ser Met Tyr Phe Asn Lys Ile Ile Ser Phe Asn Ile Ile Ser Arg 
            20                  25                  30          


Ile Val Ile Cys Ile Phe Leu Ile Cys Gly Met Phe Met Ala Gly Ala 
        35                  40                  45              


Ser Glu Lys Tyr Asp Ala Asn Ala Pro Gln Gln Val Gln Pro Tyr Ser 
    50                  55                  60                  


Val Ser Ser Ser Ala Phe Glu Asn Leu His Pro Asn Asn Glu Met Glu 
65                  70                  75                  80  


Ser Ser Ile Asn Pro Phe Ser Ala Ser Asp Thr Glu Arg Asn Ala Ala 
                85                  90                  95      


Ile Ile Asp Arg Ala Asn Lys Glu Gln Glu Thr Glu Ala Val Asn Lys 
            100                 105                 110         


Met Ile Ser Thr Gly Ala Arg Leu Ala Ala Ser Gly Arg Ala Ser Asp 
        115                 120                 125             


Val Ala His Ser Met Val Gly Asp Ala Val Asn Gln Glu Ile Lys Gln 
    130                 135                 140                 


Trp Leu Asn Arg Phe Gly Thr Ala Gln Val Asn Leu Asn Phe Asp Lys 
145                 150                 155                 160 


Asn Phe Ser Leu Lys Glu Ser Ser Leu Asp Trp Leu Ala Pro Trp Tyr 
                165                 170                 175     


Asp Ser Ala Ser Phe Leu Phe Phe Ser Gln Leu Gly Ile Arg Asn Lys 
            180                 185                 190         


Asp Ser Arg Asn Thr Leu Asn Leu Gly Val Gly Ile Arg Thr Leu Glu 
        195                 200                 205             


Asn Gly Trp Leu Tyr Gly Leu Asn Thr Phe Tyr Asp Asn Asp Leu Thr 
    210                 215                 220                 


Gly His Asn His Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp Tyr 
225                 230                 235                 240 


Leu Gln Leu Ala Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His Ser 
                245                 250                 255     


Ser Arg Asp Phe Ser Asp Tyr Lys Glu Arg Pro Ala Thr Gly Gly Asp 
            260                 265                 270         


Leu Arg Ala Asn Ala Tyr Leu Pro Ala Leu Pro Gln Leu Gly Gly Lys 
        275                 280                 285             


Leu Met Tyr Glu Gln Tyr Thr Gly Glu Arg Val Ala Leu Phe Gly Lys 
    290                 295                 300                 


Asp Asn Leu Gln Arg Asn Pro Tyr Ala Val Thr Ala Gly Ile Asn Tyr 
305                 310                 315                 320 


Thr Pro Val Pro Leu Leu Thr Val Gly Val Asp Gln Arg Met Gly Lys 
                325                 330                 335     


Ser Ser Lys His Glu Thr Gln Trp Asn Leu Gln Met Asn Tyr Arg Leu 
            340                 345                 350         


Gly Glu Ser Phe Gln Ser Gln Leu Ser Pro Ser Ala Val Ala Gly Thr 
        355                 360                 365             


Arg Leu Leu Ala Glu Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn Asn 
    370                 375                 380                 


Ile Val Leu Glu Tyr Gln Lys Gln Gln Val Val Lys Leu Thr Leu Ser 
385                 390                 395                 400 


Pro Ala Thr Ile Ser Gly Leu Pro Gly Gln Val Tyr Gln Val Asn Ala 
                405                 410                 415     


Gln Val Gln Gly Ala Ser Ala Val Arg Glu Ile Val Trp Ser Asp Ala 
            420                 425                 430         


Glu Leu Ile Ala Ala Gly Gly Thr Leu Thr Pro Leu Ser Thr Thr Gln 
        435                 440                 445             


Phe Asn Leu Val Leu Pro Pro Tyr Lys Arg Thr Ala Gln Val Ser Arg 
    450                 455                 460                 


Val Thr Asp Asp Leu Thr Ala Asn Phe Tyr Ser Leu Ser Ala Leu Ala 
465                 470                 475                 480 


Val Asp His Gln Gly Asn Arg Ser Asn Ser Phe Thr Leu Ser Val Thr 
                485                 490                 495     


Val Gln Gln Pro Gln Leu Thr Leu Thr Ala Ala Val Ile Gly Asp Gly 
            500                 505                 510         


Ala Pro Ala Asn Gly Lys Thr Ala Ile Thr Val Glu Phe Thr Val Ala 
        515                 520                 525             


Asp Phe Glu Gly Lys Pro Leu Ala Gly Gln Glu Val Val Ile Thr Thr 
    530                 535                 540                 


Asn Asn Gly Ala Leu Pro Asn Lys Ile Thr Glu Lys Thr Asp Ala Asn 
545                 550                 555                 560 


Gly Val Ala Arg Ile Ala Leu Thr Asn Thr Thr Asp Gly Val Thr Val 
                565                 570                 575     


Val Thr Ala Glu Val Glu Gly Gln Arg Gln Ser Val Asp Thr His Phe 
            580                 585                 590         


Val Lys Gly Thr Ile Ala Ala Asp Lys Ser Thr Leu Ala Ala Val 
        595                 600                 605         


<210> 991
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> LppOmpA display tag

<400> 991
Lys Ala Thr Lys Leu Val Leu Gly Ala Val Ile Leu Gly Ser Thr Leu 
1               5                   10                  15      


Leu Ala Gly Cys Ser Ser Asn Ala Lys Ile Asp Gln Gly Ile Asn Pro 
            20                  25                  30          


Tyr Val Gly Phe Glu Met Gly Tyr Asp Trp Leu Gly Arg Met Pro Tyr 
        35                  40                  45              


Lys Gly Ser Val Glu Asn Gly Ala Tyr Lys Ala Gln Gly Val Gln Leu 
    50                  55                  60                  


Thr Ala Lys Leu Gly Tyr Pro Ile Thr Asp Asp Leu Asp Ile Tyr Thr 
65                  70                  75                  80  


Arg Leu Gly Gly Met Val Trp Arg Ala Asp Thr Lys Ser Asn Val Tyr 
                85                  90                  95      


Gly Lys Asn His Asp Thr Gly Val Ser Pro Val Phe Ala Gly Gly Val 
            100                 105                 110         


Glu Tyr Ala Ile Thr Pro Glu Ile Ala Thr Arg Leu Glu Tyr Gln Trp 
        115                 120                 125             


Thr Asn Asn Ile Gly Asp Ala His Thr Ile Gly Thr Arg Pro Asp Asn 
    130                 135                 140                 


Gly Ile Pro Gly 
145             


<210> 992
<211> 658
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> IntiminN display tag

<400> 992
Ile Thr His Gly Cys Tyr Thr Arg Thr Arg His Lys His Lys Leu Lys 
1               5                   10                  15      


Lys Thr Leu Ile Met Leu Ser Ala Gly Leu Gly Leu Phe Phe Tyr Val 
            20                  25                  30          


Asn Gln Asn Ser Phe Ala Asn Gly Glu Asn Tyr Phe Lys Leu Gly Ser 
        35                  40                  45              


Asp Ser Lys Leu Leu Thr His Asp Ser Tyr Gln Asn Arg Leu Phe Tyr 
    50                  55                  60                  


Thr Leu Lys Thr Gly Glu Thr Val Ala Asp Leu Ser Lys Ser Gln Asp 
65                  70                  75                  80  


Ile Asn Leu Ser Thr Ile Trp Ser Leu Asn Lys His Leu Tyr Ser Ser 
                85                  90                  95      


Glu Ser Glu Met Met Lys Ala Ala Pro Gly Gln Gln Ile Ile Leu Pro 
            100                 105                 110         


Leu Lys Lys Leu Pro Phe Glu Tyr Ser Ala Leu Pro Leu Leu Gly Ser 
        115                 120                 125             


Ala Pro Leu Val Ala Ala Gly Gly Val Ala Gly His Thr Asn Lys Leu 
    130                 135                 140                 


Thr Lys Met Ser Pro Asp Val Thr Lys Ser Asn Met Thr Asp Asp Lys 
145                 150                 155                 160 


Ala Leu Asn Tyr Ala Ala Gln Gln Ala Ala Ser Leu Gly Ser Gln Leu 
                165                 170                 175     


Gln Ser Arg Ser Leu Asn Gly Asp Tyr Ala Lys Asp Thr Ala Leu Gly 
            180                 185                 190         


Ile Ala Gly Asn Gln Ala Ser Ser Gln Leu Gln Ala Trp Leu Gln His 
        195                 200                 205             


Tyr Gly Thr Ala Glu Val Asn Leu Gln Ser Gly Asn Asn Phe Asp Gly 
    210                 215                 220                 


Ser Ser Leu Asp Phe Leu Leu Pro Phe Tyr Asp Ser Glu Lys Met Leu 
225                 230                 235                 240 


Ala Phe Gly Gln Val Gly Ala Arg Tyr Ile Asp Ser Arg Phe Thr Ala 
                245                 250                 255     


Asn Leu Gly Ala Gly Gln Arg Phe Phe Leu Pro Ala Asn Met Leu Gly 
            260                 265                 270         


Tyr Asn Val Phe Ile Asp Gln Asp Phe Ser Gly Asp Asn Thr Arg Leu 
        275                 280                 285             


Gly Ile Gly Gly Glu Tyr Trp Arg Asp Tyr Phe Lys Ser Ser Val Asn 
    290                 295                 300                 


Gly Tyr Phe Arg Met Ser Gly Trp His Glu Ser Tyr Asn Lys Lys Asp 
305                 310                 315                 320 


Tyr Asp Glu Arg Pro Ala Asn Gly Phe Asp Ile Arg Phe Asn Gly Tyr 
                325                 330                 335     


Leu Pro Ser Tyr Pro Ala Leu Gly Ala Lys Leu Ile Tyr Glu Gln Tyr 
            340                 345                 350         


Tyr Gly Asp Asn Val Ala Leu Phe Asn Ser Asp Lys Leu Gln Ser Asn 
        355                 360                 365             


Pro Gly Ala Ala Thr Val Gly Val Asn Tyr Thr Pro Ile Pro Leu Val 
    370                 375                 380                 


Thr Met Gly Ile Asp Tyr Arg His Gly Thr Gly Asn Glu Asn Asp Leu 
385                 390                 395                 400 


Leu Tyr Ser Met Gln Phe Arg Tyr Gln Phe Asp Lys Ser Trp Ser Gln 
                405                 410                 415     


Gln Ile Glu Pro Gln Tyr Val Asn Glu Leu Arg Thr Leu Ser Gly Ser 
            420                 425                 430         


Arg Tyr Asp Leu Val Gln Arg Asn Asn Asn Ile Ile Leu Glu Tyr Lys 
        435                 440                 445             


Lys Gln Asp Ile Leu Ser Leu Asn Ile Pro His Asp Ile Asn Gly Thr 
    450                 455                 460                 


Glu His Ser Thr Gln Lys Ile Gln Leu Ile Val Lys Ser Lys Tyr Gly 
465                 470                 475                 480 


Leu Asp Arg Ile Val Trp Asp Asp Ser Ala Leu Arg Ser Gln Gly Gly 
                485                 490                 495     


Gln Ile Gln His Ser Gly Ser Gln Ser Ala Gln Asp Tyr Gln Ala Ile 
            500                 505                 510         


Leu Pro Ala Tyr Val Gln Gly Gly Ser Asn Ile Tyr Lys Val Thr Ala 
        515                 520                 525             


Arg Ala Tyr Tyr Arg Asn Gly Asn Ser Ser Asn Asn Val Gln Leu Thr 
    530                 535                 540                 


Ile Thr Val Leu Ser Asn Gly Gln Val Val Asp Gln Val Gly Val Thr 
545                 550                 555                 560 


Asp Phe Thr Ala Asp Lys Thr Ser Ala Lys Ala Asp Asn Ala Asp Thr 
                565                 570                 575     


Ile Thr Tyr Thr Ala Thr Val Lys Lys Asn Gly Val Ala Gln Ala Asn 
            580                 585                 590         


Val Pro Val Ser Phe Asn Ile Val Ser Gly Thr Ala Thr Leu Gly Ala 
        595                 600                 605             


Asn Ser Ala Lys Thr Asp Ala Asn Gly Lys Ala Thr Val Thr Leu Lys 
    610                 615                 620                 


Ser Ser Thr Pro Gly Gln Val Val Val Ser Ala Lys Thr Ala Glu Met 
625                 630                 635                 640 


Thr Ser Ala Leu Asn Ala Ser Ala Val Ile Phe Phe Asp Gln Thr Lys 
                645                 650                 655     


Ala Ser 
        


<210> 993
<211> 5121
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> pUC-ptet-B6H12antihCD47scFv-V5-HIS

<400> 993
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaagtga aaggaggtaa attcatatga ctagtcaatt gggtggtagc     1080

gaggtccagc tggtggaatc tggcggagac ttagtaaagc cgggaggttc gttgaagttg     1140

agttgcgctg ctagtgggtt tacgtttagc ggctatggta tgtcatgggt ccgccaaaca     1200

cccgataaac gtttagagtg ggtcgccacg attacgagtg gaggcaccta cacctattat     1260

ccggattctg tcaaaggccg ctttactatt tctcgtgata atgcaaagaa caccttatat     1320

ttacagatcg actccttgaa gtctgaggat accgcaattt atttctgtgc ccgttcgtta     1380

gccggtaatg ctatggatta ttgggggcaa ggcacatctg tcacagtctc atccggagga     1440

ggcggatcag gtggtggcgg ttctggcggc ggcggatctg acattgtgat gacacaatca     1500

cctgcgacac tttcggttac tccaggagac cgcgttagct tgtcgtgtcg cgcctctcaa     1560

accatcagtg actacttaca ttggtaccaa cagaaatccc atgaatcgcc acgcttactt     1620

attaagtttg cgtcccaatc aattagtggt attccgtcgc gctttagtgg tagcggttct     1680

ggttctgatt tcacattgtc aatcaacagc gtggagccgg aggatgttgg tgtttactac     1740

tgccaaaacg gtcacggctt tccacgtaca ttcggagggg gaacgaagtt ggaaattaaa     1800

ggcagcggcg agctcggtgg cagtggtaag cctatcccta accctctcct cggcctcgat     1860

tctacgggat ccggtcatca tcaccatcac cattgagcat gctaatcagc cgtggaattc     1920

gaattcggtc tcaggaggaa gggcgaattc tgcagatatc catcacactg gcggccgctc     1980

gagcatgcat ctagagggcc caattcgccc tatagtgagt cgtattacaa ttcactggcc     2040

gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa tcgccttgca     2100

gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc     2160

caacagttgc gcagcctata cgtacggcag tttaaggttt acacctataa aagagagagc     2220

cgttatcgtc tgtttgtgga tgtacagagt gatattattg acacgccggg gcgacggatg     2280

gtgatccccc tggccagtgc acgtctgctg tcagataaag tctcccgtga actttacccg     2340

gtggtgcata tcggggatga aagctggcgc atgatgacca ccgatatggc cagtgtgccg     2400

gtctccgtta tcggggaaga agtggctgat ctcagccacc gcgaaaatga catcaaaaac     2460

gccattaacc tgatgttctg gggaatataa atgtcaggca tgagattatc aaaaaggatc     2520

ttcacctaga tccttttcac gtagaaagcc agtccgcaga aacggtgctg accccggatg     2580

aatgtcagct actgggctat ctggacaagg gaaaacgcaa gcgcaaagag aaagcaggta     2640

gcttgcagtg ggcttacatg gcgatagcta gactgggcgg ttttatggac agcaagcgaa     2700

ccggaattgc cagctggggc gccctctggt aaggttggga agccctgcaa agtaaactgg     2760

atggctttct cgccgccaag gatctgatgg cgcaggggat caagctctga tcaagagaca     2820

ggatgaggat cgtttcgcat gattgaacaa gatggattgc acgcaggttc tccggccgct     2880

tgggtggaga ggctattcgg ctatgactgg gcacaacaga caatcggctg ctctgatgcc     2940

gccgtgttcc ggctgtcagc gcaggggcgc ccggttcttt ttgtcaagac cgacctgtcc     3000

ggtgccctga atgaactgca agacgaggca gcgcggctat cgtggctggc cacgacgggc     3060

gttccttgcg cagctgtgct cgacgttgtc actgaagcgg gaagggactg gctgctattg     3120

ggcgaagtgc cggggcagga tctcctgtca tctcaccttg ctcctgccga gaaagtatcc     3180

atcatggctg atgcaatgcg gcggctgcat acgcttgatc cggctacctg cccattcgac     3240

caccaagcga aacatcgcat cgagcgagca cgtactcgga tggaagccgg tcttgtcgat     3300

caggatgatc tggacgaaga gcatcagggg ctcgcgccag ccgaactgtt cgccaggctc     3360

aaggcgagca tgcccgacgg cgaggatctc gtcgtgaccc atggcgatgc ctgcttgccg     3420

aatatcatgg tggaaaatgg ccgcttttct ggattcatcg actgtggccg gctgggtgtg     3480

gcggaccgct atcaggacat agcgttggct acccgtgata ttgctgaaga gcttggcggc     3540

gaatgggctg accgcttcct cgtgctttac ggtatcgccg ctcccgattc gcagcgcatc     3600

gccttctatc gccttcttga cgagttcttc tgaattatta acgcttacaa tttcctgatg     3660

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatacaggt ggcacttttc     3720

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     3780

cgctcatgag acaataaccc tgataaatgc ttcaataata gcacgtgagg agggccacca     3840

tggccaagtt gaccagtgcc gttccggtgc tcaccgcgcg cgacgtcgcc ggagcggtcg     3900

agttctggac cgaccggctc gggttctccc gggacttcgt ggaggacgac ttcgccggtg     3960

tggtccggga cgacgtgacc ctgttcatca gcgcggtcca ggaccaggtg gtgccggaca     4020

acaccctggc ctgggtgtgg gtgcgcggcc tggacgagct gtacgccgag tggtcggagg     4080

tcgtgtccac gaacttccgg gacgcctccg ggccggccat gaccgagatc ggcgagcagc     4140

cgtgggggcg ggagttcgcc ctgcgcgacc cggccggcaa ctgcgtgcac ttcgtggccg     4200

aggagcagga ctgacacgtg ctaaaacttc atttttaatt taaaaggatc taggtgaaga     4260

tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt     4320

cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct     4380

gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc     4440

taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc     4500

ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc     4560

tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg     4620

ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt     4680

cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg     4740

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     4800

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     4860

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     4920

gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc ctgggctttt     4980

gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta     5040

ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt     5100

cagtgagcga ggaagcggaa g                                               5121


<210> 994
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> B6H12-anti-CD47-scFv polypeptide sequence

<400> 994
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Thr Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser 
                165                 170                 175     


Pro Arg Leu Leu Ile Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile 
        195                 200                 205             


Asn Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly 
    210                 215                 220                 


His Gly Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


<210> 995
<211> 5133
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> pUC-ptet-5F9antihCD47scFv-V5-HIS

<400> 995
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaagtga aaggaggtaa attcatatga ctagtcaatt gggtggtagc     1080

caggtgcagc ttgtgcagag tggcgctgaa gtgaagaaac cgggcgcatc agtgaaagtg     1140

agctgcaaag caagcggtta taccttcacg aactataaca tgcactgggt acgtcaagca     1200

cccggccagc gtcttgagtg gatgggcacc atttatcctg gaaacgacga cacatcctac     1260

aaccaaaagt ttaaggaccg cgtaactatc actgctgaca cttcagcttc cacagcatat     1320

atggagctta gtagcctgcg tagtgaagac acagcggtct actactgcgc acgtggaggg     1380

tatcgtgcga tggactactg ggggcagggc acacttgtga ctgtttcatc tggcggtgga     1440

ggctctggag gggggggtag cggggggggc ggtagcgata tcgtaatgac tcagtcccca     1500

ctttccttac ccgtcacacc gggcgaacct gcatctatta gctgtcgttc gtcgcaaagc     1560

attgtttact cgaatgggaa tacgtacttg gggtggtatc ttcaaaaacc agggcagtcc     1620

cctcagttgt tgatctacaa ggtgtccaac cgctttagtg gggtgcctga tcgtttctct     1680

ggcagtggta gtggtaccga cttcacgctt aaaatttccc gtgtcgaagc agaagacgtt     1740

ggcgtatatt actgcttcca aggcagtcat gtgccataca cgttcgggca aggcaccaaa     1800

cttgagatca aaggcagcgg cgagctcggt ggcagtggta agcctatccc taaccctctc     1860

ctcggcctcg attctacggg atccggtcat catcaccatc accattgagc atgctaatca     1920

gccgtggaat tcgaattcgg tctcaggagg aagggcgaat tctgcagata tccatcacac     1980

tggcggccgc tcgagcatgc atctagaggg cccaattcgc cctatagtga gtcgtattac     2040

aattcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt tacccaactt     2100

aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga ggcccgcacc     2160

gatcgccctt cccaacagtt gcgcagccta tacgtacggc agtttaaggt ttacacctat     2220

aaaagagaga gccgttatcg tctgtttgtg gatgtacaga gtgatattat tgacacgccg     2280

gggcgacgga tggtgatccc cctggccagt gcacgtctgc tgtcagataa agtctcccgt     2340

gaactttacc cggtggtgca tatcggggat gaaagctggc gcatgatgac caccgatatg     2400

gccagtgtgc cggtctccgt tatcggggaa gaagtggctg atctcagcca ccgcgaaaat     2460

gacatcaaaa acgccattaa cctgatgttc tggggaatat aaatgtcagg catgagatta     2520

tcaaaaagga tcttcaccta gatccttttc acgtagaaag ccagtccgca gaaacggtgc     2580

tgaccccgga tgaatgtcag ctactgggct atctggacaa gggaaaacgc aagcgcaaag     2640

agaaagcagg tagcttgcag tgggcttaca tggcgatagc tagactgggc ggttttatgg     2700

acagcaagcg aaccggaatt gccagctggg gcgccctctg gtaaggttgg gaagccctgc     2760

aaagtaaact ggatggcttt ctcgccgcca aggatctgat ggcgcagggg atcaagctct     2820

gatcaagaga caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt     2880

tctccggccg cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc     2940

tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag     3000

accgacctgt ccggtgccct gaatgaactg caagacgagg cagcgcggct atcgtggctg     3060

gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac     3120

tggctgctat tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc     3180

gagaaagtat ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc     3240

tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc     3300

ggtcttgtcg atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg     3360

ttcgccaggc tcaaggcgag catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat     3420

gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc     3480

cggctgggtg tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa     3540

gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat     3600

tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgaattat taacgcttac     3660

aatttcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacag     3720

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     3780

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tagcacgtga     3840

ggagggccac catggccaag ttgaccagtg ccgttccggt gctcaccgcg cgcgacgtcg     3900

ccggagcggt cgagttctgg accgaccggc tcgggttctc ccgggacttc gtggaggacg     3960

acttcgccgg tgtggtccgg gacgacgtga ccctgttcat cagcgcggtc caggaccagg     4020

tggtgccgga caacaccctg gcctgggtgt gggtgcgcgg cctggacgag ctgtacgccg     4080

agtggtcgga ggtcgtgtcc acgaacttcc gggacgcctc cgggccggcc atgaccgaga     4140

tcggcgagca gccgtggggg cgggagttcg ccctgcgcga cccggccggc aactgcgtgc     4200

acttcgtggc cgaggagcag gactgacacg tgctaaaact tcatttttaa tttaaaagga     4260

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     4320

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     4380

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     4440

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     4500

caaatactgt ccttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     4560

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     4620

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     4680

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     4740

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     4800

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     4860

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     4920

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     4980

tcctgggctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     5040

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     5100

agcgcagcga gtcagtgagc gaggaagcgg aag                                  5133


<210> 996
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> 5F9-anti-CD47-scFv polypeptide sequence

<400> 996
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
    130                 135                 140                 


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
145                 150                 155                 160 


Ile Val Tyr Ser Asn Gly Asn Thr Tyr Leu Gly Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
            180                 185                 190         


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210> 997
<211> 2555
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Biosafety Plasmid System Component  dap A

<400> 997
actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata       60

catatttgaa tgtatttaga aaaataaaca aataggggaa ttaaaaaaaa gcccgctcat      120

taggcgggct actacctagg ccgcggccgc gcgaattcga gctcggtacc cggggatcct      180

ctagagtcga cctgcaggca tgcaagcttg cggccgcgtc gtgactggga aaaccctggc      240

gactagtctt ggactcctgt tgatagatcc agtaatgacc tcagaactcc atctggattt      300

gttcagaacg ctcggttgcc gccgggcgtt ttttattggt gagaatccag gggtccccaa      360

taattacgat ttaaatcaca gcaaacacca cgtcggccct atcagctgcg tgctttctat      420

gagtcgttgc tgcataactt gacaattaac atccggctcg tagggtttgt ggagggccca      480

agttcactta aaaaggagat caacaatgaa agcaattttc gtactgaaac atcttaatca      540

tgctggggag ggtttctaat gttcacggga agtattgtcg cgattgttac tccgatggat      600

gaaaaaggta atgtctgtcg ggctagcttg aaaaaactga ttgattatca tgtcgccagc      660

ggtacttcgg cgatcgtttc tgttggcacc actggcgagt ccgctacctt aaatcatgac      720

gaacatgctg atgtggtgat gatgacgctg gatctggctg atgggcgcat tccggtaatt      780

gccgggaccg gcgctaacgc tactgcggaa gccattagcc tgacgcagcg cttcaatgac      840

agtggtatcg tcggctgcct gacggtaacc ccttactaca atcgtccgtc gcaagaaggt      900

ttgtatcagc atttcaaagc catcgctgag catactgacc tgccgcaaat tctgtataat      960

gtgccgtccc gtactggctg cgatctgctc ccggaaacgg tgggccgtct ggcgaaagta     1020

aaaaatatta tcggaatcaa agaggcaaca gggaacttaa cgcgtgtaaa ccagatcaaa     1080

gagctggttt cagatgattt tgttctgctg agcggcgatg atgcgagcgc gctggacttc     1140

atgcaattgg gcggtcatgg ggttatttcc gttacggcta acgtcgcagc gcgtgatatg     1200

gcccagatgt gcaaactggc agcagaaggg cattttgccg aggcacgcgt tattaatcag     1260

cgtctgatgc cattacacaa caaactattt gtcgaaccca atccaatccc ggtgaaatgg     1320

gcatgtaagg aactgggtct tgtggcgacc gatacgctgc gcctgccaat gacaccaatc     1380

accgacagtg gccgtgagac ggtcagagcg gcgcttaaac atgccggttt gctgtaagac     1440

ttttgtcagg ttcctactgt gacgactacc accgatagac tggagtgttg ctgcgaaaaa     1500

accccgccga agcggggttt tttgcgagaa gtcaccacga ttgtgcttta cacggagtag     1560

tcggcagttc cttaagtcag aatagtggac aggcggccaa gaacttcgtt catgatagtc     1620

tccggaaccc gttcgagtcg ttttccgccc cgtgctttca tatcaattgt ccggggttga     1680

tcgcaacgta caacacctgt ggtacgtatg ccaacaccat ccaacgacac cgcaaagccg     1740

gcagtgcggg caaaattgcc tccgctggtt acgggcacaa caacaggcag gcgggtcacg     1800

cgattaaagg ccgccggtgt gacaatcagc accggccgcg ttccctgctg ctcatgacct     1860

gcggtaggat caagcgagac aagccagatt tcccctcttt ccatctagta taactattgt     1920

ttctctagta acatttattg tacaacacga gcccattttt gtcaaataaa ttttaaatta     1980

tatcaacgtt aataagacgt tgtcaataaa attattttga caaaattggc cggccggcgc     2040

gccgatctga agatcagcag ttcaacctgt tgatagtacg tactaagctc tcatgtttca     2100

cgtactaagc tctcatgttt aacgtactaa gctctcatgt ttaacgaact aaaccctcat     2160

ggctaacgta ctaagctctc atggctaacg tactaagctc tcatgtttca cgtactaagc     2220

tctcatgttt gaacaataaa attaatataa atcagcaact taaatagcct ctaaggtttt     2280

aagttttata agaaaaaaaa gaatatataa ggcttttaaa gcctttaagg tttaacggtt     2340

gtggacaaca agccagggat gtaacgcact gagaagccct tagagcctct caaagcaatt     2400

ttgagtgaca caggaacact taacggctga catggggcgc gcccagctgt ctagggcggc     2460

ggatttgtcc tactcaggag agcgttcacc gacaaacaac agataaaacg aaaggcccag     2520

tctttcgact gagcctttcg ttttatttga tgcct                                2555


<210> 998
<211> 2472
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Biosafety Plasmid System Component  ThyA

<400> 998
actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata       60

catatttgaa tgtatttaga aaaataaaca aataggggaa ttaaaaaaaa gcccgctcat      120

taggcgggct actacctagg ccgcggccgc gcgaattcga gctcggtacc cggggatcct      180

ctagagtcga cctgcaggca tgcaagcttg cggccgcgtc gtgactggga aaaccctggc      240

gactagtctt ggactcctgt tgatagatcc agtaatgacc tcagaactcc atctggattt      300

gttcagaacg ctcggttgcc gccgggcgtt ttttattggt gagaatccag gggtccccaa      360

taattacgat ttaaatcaca gcaaacacca cgtcggccct atcagctgcg tgctttctat      420

gagtcgttgc tgcataactt gacaattaat catccggctc gtagggtttg tggagggccc      480

aagttcactt aaaaaggaga tcaacaatga aagcaatttt cgtactgaaa catcttaatc      540

atgctgggga gggtttctaa tgaaacagta tttagaactg atgcaaaaag tgctcgacga      600

aggcacacag aaaaacgacc gtaccggaac cggaacgctt tccatttttg gtcatcagat      660

gcgttttaac ctgcaagatg gattcccgct ggtgacaact aaacgttgcc acctgcgttc      720

catcatccat gaactgctgt ggtttcttca gggcgacact aacattgctt atctacacga      780

aaacaatgtc accatctggg acgaatgggc cgatgaaaac ggcgacctcg ggccagtgta      840

tggtaaacag tggcgtgcct ggccaacgcc agatggtcgt catattgacc agatcactac      900

ggtactgaac cagctgaaaa acgacccgga ttcgcgccgc attattgttt cagcgtggaa      960

cgtaggcgaa ctggataaaa tggcgctggc accgtgccat gcattcttcc agttctatgt     1020

ggcagacggc aaactctctt gccagcttta tcagcgctcc tgtgacgtct tcctcggcct     1080

gccgttcaac attgccagct acgcgttatt ggtgcatatg atggcgcagc agtgcgatct     1140

ggaagtgggt gattttgtct ggaccggtgg cgacacgcat ctgtacagca accatatgga     1200

tcaaactcat ctgcaattaa gccgcgaacc gcgtccgctg ccgaagttga ttatcaaacg     1260

taaacccgaa tccatcttcg actaccgttt cgaagacttt gagattgaag gctacgatcc     1320

gcatccgggc attaaagcgc cggtggctat ctaagacttt tgtcaggttc ctactgtgac     1380

gactaccacc gatagactgg agtgttgctg cgaaaaaacc ccgccgaagc ggggtttttt     1440

gcgagaagtc accacgattg tgctttacac ggagtagtcg gcagttcctt aagtcagaat     1500

agtggacagg cggccaagaa cttcgttcat gatagtctcc ggaacccgtt cgagtcgttt     1560

tccgccccgt gctttcatat caattgtccg gggttgatcg caacgtacaa cacctgtggt     1620

acgtatgcca acaccatcca acgacaccgc aaagccggca gtgcgggcaa aattgcctcc     1680

gctggttacg ggcacaacaa caggcaggcg ggtcacgcga ttaaaggccg ccggtgtgac     1740

aatcagcacc ggccgcgttc cctgctgctc atgacctgcg gtaggatcaa gcgagacaag     1800

ccagatttcc cctctttcca tctagtataa ctattgtttc tctagtaaca tttattgtac     1860

aacacgagcc catttttgtc aaataaattt taaattatat caacgttaat aagacgttgt     1920

caataaaatt attttgacaa aattggccgg ccggcgcgcc gatctgaaga tcagcagttc     1980

aacctgttga tagtacgtac taagctctca tgtttcacgt actaagctct catgtttaac     2040

gtactaagct ctcatgttta acgaactaaa ccctcatggc taacgtacta agctctcatg     2100

gctaacgtac taagctctca tgtttcacgt actaagctct catgtttgaa caataaaatt     2160

aatataaatc agcaacttaa atagcctcta aggttttaag ttttataaga aaaaaaagaa     2220

tatataaggc ttttaaagcc tttaaggttt aacggttgtg gacaacaagc cagggatgta     2280

acgcactgag aagcccttag agcctctcaa agcaattttg agtgacacag gaacacttaa     2340

cggctgacat ggggcgcgcc cagctgtcta gggcggcgga tttgtcctac tcaggagagc     2400

gttcaccgac aaacaacaga taaaacgaaa ggcccagtct ttcgactgag cctttcgttt     2460

tatttgatgc ct                                                         2472


<210> 999
<211> 333
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Kid toxin (reverse orientation)

<400> 999
ttaagtcaga atagtggaca ggcggccaag aacttcgttc atgatagtct ccggaacccg       60

ttcgagtcgt tttccgcccc gtgctttcat atcaattgtc cggggttgat cgcaacgtac      120

aacacctgtg gtacgtatgc caacaccatc caacgacacc gcaaagccgg cagtgcgggc      180

aaaattgcct ccgctggtta cgggcacaac aacaggcagg cgggtcacgc gattaaaggc      240

cgccggtgtg acaatcagca ccggccgcgt tccctgctgc tcatgacctg cggtaggatc      300

aagcgagaca agccagattt cccctctttc cat                                   333


<210> 1000
<211> 879
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> dapA

<400> 1000
atgttcacgg gaagtattgt cgcgattgtt actccgatgg atgaaaaagg taatgtctgt       60

cgggctagct tgaaaaaact gattgattat catgtcgcca gcggtacttc ggcgatcgtt      120

tctgttggca ccactggcga gtccgctacc ttaaatcatg acgaacatgc tgatgtggtg      180

atgatgacgc tggatctggc tgatgggcgc attccggtaa ttgccgggac cggcgctaac      240

gctactgcgg aagccattag cctgacgcag cgcttcaatg acagtggtat cgtcggctgc      300

ctgacggtaa ccccttacta caatcgtccg tcgcaagaag gtttgtatca gcatttcaaa      360

gccatcgctg agcatactga cctgccgcaa attctgtata atgtgccgtc ccgtactggc      420

tgcgatctgc tcccggaaac ggtgggccgt ctggcgaaag taaaaaatat tatcggaatc      480

aaagaggcaa cagggaactt aacgcgtgta aaccagatca aagagctggt ttcagatgat      540

tttgttctgc tgagcggcga tgatgcgagc gcgctggact tcatgcaatt gggcggtcat      600

ggggttattt ccgttacggc taacgtcgca gcgcgtgata tggcccagat gtgcaaactg      660

gcagcagaag ggcattttgc cgaggcacgc gttattaatc agcgtctgat gccattacac      720

aacaaactat ttgtcgaacc caatccaatc ccggtgaaat gggcatgtaa ggaactgggt      780

cttgtggcga ccgatacgct gcgcctgcca atgacaccaa tcaccgacag tggccgtgag      840

acggtcagag cggcgcttaa acatgccggt ttgctgtaa                             879


<210> 1001
<211> 795
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> thyA

<400> 1001
atgaaacagt atttagaact gatgcaaaaa gtgctcgacg aaggcacaca gaaaaacgac       60

cgtaccggaa ccggaacgct ttccattttt ggtcatcaga tgcgttttaa cctgcaagat      120

ggattcccgc tggtgacaac taaacgttgc cacctgcgtt ccatcatcca tgaactgctg      180

tggtttcttc agggcgacac taacattgct tatctacacg aaaacaatgt caccatctgg      240

gacgaatggg ccgatgaaaa cggcgacctc gggccagtgt atggtaaaca gtggcgtgcc      300

tggccaacgc cagatggtcg tcatattgac cagatcacta cggtactgaa ccagctgaaa      360

aacgacccgg attcgcgccg cattattgtt tcagcgtgga acgtaggcga actggataaa      420

atggcgctgg caccgtgcca tgcattcttc cagttctatg tggcagacgg caaactctct      480

tgccagcttt atcagcgctc ctgtgacgtc ttcctcggcc tgccgttcaa cattgccagc      540

tacgcgttat tggtgcatat gatggcgcag cagtgcgatc tggaagtggg tgattttgtc      600

tggaccggtg gcgacacgca tctgtacagc aaccatatgg atcaaactca tctgcaatta      660

agccgcgaac cgcgtccgct gccgaagttg attatcaaac gtaaacccga atccatcttc      720

gactaccgtt tcgaagactt tgagattgaa ggctacgatc cgcatccggg cattaaagcg      780

ccggtggcta tctaa                                                       795


<210> 1002
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> Kid toxin polypeptide

<400> 1002
Met Glu Arg Gly Glu Ile Trp Leu Val Ser Leu Asp Pro Thr Ala Gly 
1               5                   10                  15      


His Glu Gln Gln Gly Thr Arg Pro Val Leu Ile Val Thr Pro Ala Ala 
            20                  25                  30          


Phe Asn Arg Val Thr Arg Leu Pro Val Val Val Pro Val Thr Ser Gly 
        35                  40                  45              


Gly Asn Phe Ala Arg Thr Ala Gly Phe Ala Val Ser Leu Asp Gly Val 
    50                  55                  60                  


Gly Ile Arg Thr Thr Gly Val Val Arg Cys Asp Gln Pro Arg Thr Ile 
65                  70                  75                  80  


Asp Met Lys Ala Arg Gly Gly Lys Arg Leu Glu Arg Val Pro Glu Thr 
                85                  90                  95      


Ile Met Asn Glu Val Leu Gly Arg Leu Ser Thr Ile Leu Thr 
            100                 105                 110 


<210> 1003
<211> 292
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> dapA polypeptide

<400> 1003
Met Phe Thr Gly Ser Ile Val Ala Ile Val Thr Pro Met Asp Glu Lys 
1               5                   10                  15      


Gly Asn Val Cys Arg Ala Ser Leu Lys Lys Leu Ile Asp Tyr His Val 
            20                  25                  30          


Ala Ser Gly Thr Ser Ala Ile Val Ser Val Gly Thr Thr Gly Glu Ser 
        35                  40                  45              


Ala Thr Leu Asn His Asp Glu His Ala Asp Val Val Met Met Thr Leu 
    50                  55                  60                  


Asp Leu Ala Asp Gly Arg Ile Pro Val Ile Ala Gly Thr Gly Ala Asn 
65                  70                  75                  80  


Ala Thr Ala Glu Ala Ile Ser Leu Thr Gln Arg Phe Asn Asp Ser Gly 
                85                  90                  95      


Ile Val Gly Cys Leu Thr Val Thr Pro Tyr Tyr Asn Arg Pro Ser Gln 
            100                 105                 110         


Glu Gly Leu Tyr Gln His Phe Lys Ala Ile Ala Glu His Thr Asp Leu 
        115                 120                 125             


Pro Gln Ile Leu Tyr Asn Val Pro Ser Arg Thr Gly Cys Asp Leu Leu 
    130                 135                 140                 


Pro Glu Thr Val Gly Arg Leu Ala Lys Val Lys Asn Ile Ile Gly Ile 
145                 150                 155                 160 


Lys Glu Ala Thr Gly Asn Leu Thr Arg Val Asn Gln Ile Lys Glu Leu 
                165                 170                 175     


Val Ser Asp Asp Phe Val Leu Leu Ser Gly Asp Asp Ala Ser Ala Leu 
            180                 185                 190         


Asp Phe Met Gln Leu Gly Gly His Gly Val Ile Ser Val Thr Ala Asn 
        195                 200                 205             


Val Ala Ala Arg Asp Met Ala Gln Met Cys Lys Leu Ala Ala Glu Gly 
    210                 215                 220                 


His Phe Ala Glu Ala Arg Val Ile Asn Gln Arg Leu Met Pro Leu His 
225                 230                 235                 240 


Asn Lys Leu Phe Val Glu Pro Asn Pro Ile Pro Val Lys Trp Ala Cys 
                245                 250                 255     


Lys Glu Leu Gly Leu Val Ala Thr Asp Thr Leu Arg Leu Pro Met Thr 
            260                 265                 270         


Pro Ile Thr Asp Ser Gly Arg Glu Thr Val Arg Ala Ala Leu Lys His 
        275                 280                 285             


Ala Gly Leu Leu 
    290         


<210> 1004
<211> 264
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> ThyA polypeptide

<400> 1004
Met Lys Gln Tyr Leu Glu Leu Met Gln Lys Val Leu Asp Glu Gly Thr 
1               5                   10                  15      


Gln Lys Asn Asp Arg Thr Gly Thr Gly Thr Leu Ser Ile Phe Gly His 
            20                  25                  30          


Gln Met Arg Phe Asn Leu Gln Asp Gly Phe Pro Leu Val Thr Thr Lys 
        35                  40                  45              


Arg Cys His Leu Arg Ser Ile Ile His Glu Leu Leu Trp Phe Leu Gln 
    50                  55                  60                  


Gly Asp Thr Asn Ile Ala Tyr Leu His Glu Asn Asn Val Thr Ile Trp 
65                  70                  75                  80  


Asp Glu Trp Ala Asp Glu Asn Gly Asp Leu Gly Pro Val Tyr Gly Lys 
                85                  90                  95      


Gln Trp Arg Ala Trp Pro Thr Pro Asp Gly Arg His Ile Asp Gln Ile 
            100                 105                 110         


Thr Thr Val Leu Asn Gln Leu Lys Asn Asp Pro Asp Ser Arg Arg Ile 
        115                 120                 125             


Ile Val Ser Ala Trp Asn Val Gly Glu Leu Asp Lys Met Ala Leu Ala 
    130                 135                 140                 


Pro Cys His Ala Phe Phe Gln Phe Tyr Val Ala Asp Gly Lys Leu Ser 
145                 150                 155                 160 


Cys Gln Leu Tyr Gln Arg Ser Cys Asp Val Phe Leu Gly Leu Pro Phe 
                165                 170                 175     


Asn Ile Ala Ser Tyr Ala Leu Leu Val His Met Met Ala Gln Gln Cys 
            180                 185                 190         


Asp Leu Glu Val Gly Asp Phe Val Trp Thr Gly Gly Asp Thr His Leu 
        195                 200                 205             


Tyr Ser Asn His Met Asp Gln Thr His Leu Gln Leu Ser Arg Glu Pro 
    210                 215                 220                 


Arg Pro Leu Pro Lys Leu Ile Ile Lys Arg Lys Pro Glu Ser Ile Phe 
225                 230                 235                 240 


Asp Tyr Arg Phe Glu Asp Phe Glu Ile Glu Gly Tyr Asp Pro His Pro 
                245                 250                 255     


Gly Ile Lys Ala Pro Val Ala Ile 
            260                 


<210> 1005
<211> 1490
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Biosafety Chromosomal Construct -  low copy Rep (Pi)
      and Kis antitoxin (as shown in Fig. 76C)

<400> 1005
ttgacggcta gctcagtcct aggtacagtg ctagcggatc tgctggaaca ggtggtgaga       60

ctcaaggtca tgatggacgt gaacaaaaaa acgaaaattc gccaccgaaa cgagctaaat      120

cacaccctgg ctcaacttcc tttgcccgca aagcgagtga tgtatatggc gcttgctccc      180

attgatagca aagaacctct tgaacgaggg cgagttttca aaattagggc tgaagacctt      240

gcagcgctcg ccaaaatcac cccatcgctt gcttatcgac aattaaaaga gggtggtaaa      300

ttacttggtg ccagcaaaat ttcgctaaga ggggatgata tcattgcttt agctaaagag      360

cttaacctgc tctttactgc taaaaactcc cctgaagagt tagaccttaa cattattgag      420

tggatagctt attcaaatga tgaaggatac ttgtctttaa aattcaccag aaccatagaa      480

ccatatatct ctagccttat tgggaaaaaa aataaattca caacgcaatt gttaacggca      540

agcttacgct taagtagcca gtattcatct tctctttatc aacttatcag gaagcattac      600

tctaatttta agaagaaaaa ttattttatt atttccgttg atgagttaaa ggaagagtta      660

atagcttata cttttgataa agatggaaat attgagtaca aataccctga ctttcctatt      720

tttaaaaggg atgtgttaaa taaagccatt gctgaaatta aaaagaaaac agaaatatcg      780

tttgttggct tcactgttca tgaaaaagaa ggaagaaaaa ttagtaagct gaagttcgaa      840

tttgtcgttg atgaagatga attttctggc gataaagatg atgaagcttt ttttatgaat      900

ttatctgaag ctgatgcagc ttttctcaag gtatttgatg aaaccgtacc tcccaaaaaa      960

gctaaggggt gaggatctcc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg     1020

cctttcgttt tatctgttgt ttgtcggtga acgctctcta ctagagtcac actggctcac     1080

cttcgggtgg gcctttctgc gtttataccc gggaaaaaga gtattgactt aaagtctaac     1140

ctataggtat aatgtgtgga gaccagaggt aaggaggtaa caaccatgcg agtgttgaag     1200

aaacatctta atcatgctaa ggaggttttc taatgcatac cacccgactg aagagggttg     1260

gcggctcagt tatgctgacc gtcccaccgg cactgctgaa tgcgctgtct ctgggcacag     1320

ataatgaagt tggcatggtc attgataatg gccggctgat tgttgagccg tacagacgcc     1380

cgcaatattc actggctgag ctactggcac agtgtgatcc gaatgctgaa atatcagctg     1440

aagaacgaga atggctggat gcaccggcga ctggtcagga ggaaatctga                1490


<210> 1006
<211> 1490
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Biosafety Chromosomal Construct -  medium copy Rep
      (Pi) and Kis antitoxin (as shown in Fig. 76D)

<400> 1006
ttgacggcta gctcagtcct aggtacagtg ctagcggatc ttccggaaga ctaggtgaga       60

ctcaaggtca tgatggacgt gaacaaaaaa acgaaaattc gccaccgaaa cgagctaaat      120

cacaccctgg ctcaacttcc tttgcccgca aagcgagtga tgtatatggc gcttgctccc      180

attgatagca aagaacctct tgaacgaggg cgagttttca aaattagggc tgaagacctt      240

gcagcgctcg ccaaaatcac cccatcgctt gcttatcgac aattaaaaga gggtggtaaa      300

ttacttggtg ccagcaaaat ttcgctaaga ggggatgata tcattgcttt agctaaagag      360

cttaacctgc tctttactgc taaaaactcc cctgaagagt tagaccttaa cattattgag      420

tggatagctt attcaaatga tgaaggatac ttgtctttaa aattcaccag aaccatagaa      480

ccatatatct ctagccttat tgggaaaaaa aataaattca caacgcaatt gttaacggca      540

agcttacgct taagtagcca gtattcatct tctctttatc aacttatcag gaagcattac      600

tctaatttta agaagaaaaa ttattttatt atttccgttg atgagttaaa ggaagagtta      660

atagcttata cttttgataa agatggaaat attgagtaca aataccctga ctttcctatt      720

tttaaaaggg atgtgttaaa taaagccatt gctgaaatta aaaagaaaac agaaatatcg      780

tttgttggct tcactgttca tgaaaaagaa ggaagaaaaa ttagtaagct gaagttcgaa      840

tttgtcgttg atgaagatga attttctggc gataaagatg atgaagcttt ttttatgaat      900

ttatctgaag ctgatgcagc ttttctcaag gtatttgatg aaaccgtacc tcccaaaaaa      960

gctaaggggt gaggatctcc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg     1020

cctttcgttt tatctgttgt ttgtcggtga acgctctcta ctagagtcac actggctcac     1080

cttcgggtgg gcctttctgc gtttataccc gggaaaaaga gtattgactt aaagtctaac     1140

ctataggtat aatgtgtgga gaccagaggt aaggaggtaa caaccatgcg agtgttgaag     1200

aaacatctta atcatgctaa ggaggttttc taatgcatac cacccgactg aagagggttg     1260

gcggctcagt tatgctgacc gtcccaccgg cactgctgaa tgcgctgtct ctgggcacag     1320

ataatgaagt tggcatggtc attgataatg gccggctgat tgttgagccg tacagacgcc     1380

cgcaatattc actggctgag ctactggcac agtgtgatcc gaatgctgaa atatcagctg     1440

aagaacgaga atggctggat gcaccggcga ctggtcagga ggaaatctga                1490


<210> 1007
<211> 917
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Rep (Pi)

<400> 1007
tgagactcaa ggtcatgatg gacgtgaaca aaaaaacgaa aattcgccac cgaaacgagc       60

taaatcacac cctggctcaa cttcctttgc ccgcaaagcg agtgatgtat atggcgcttg      120

ctcccattga tagcaaagaa cctcttgaac gagggcgagt tttcaaaatt agggctgaag      180

accttgcagc gctcgccaaa atcaccccat cgcttgctta tcgacaatta aaagagggtg      240

gtaaattact tggtgccagc aaaatttcgc taagagggga tgatatcatt gctttagcta      300

aagagcttaa cctgctcttt actgctaaaa actcccctga agagttagac cttaacatta      360

ttgagtggat agcttattca aatgatgaag gatacttgtc tttaaaattc accagaacca      420

tagaaccata tatctctagc cttattggga aaaaaaataa attcacaacg caattgttaa      480

cggcaagctt acgcttaagt agccagtatt catcttctct ttatcaactt atcaggaagc      540

attactctaa ttttaagaag aaaaattatt ttattatttc cgttgatgag ttaaaggaag      600

agttaatagc ttatactttt gataaagatg gaaatattga gtacaaatac cctgactttc      660

ctatttttaa aagggatgtg ttaaataaag ccattgctga aattaaaaag aaaacagaaa      720

tatcgtttgt tggcttcact gttcatgaaa aagaaggaag aaaaattagt aagctgaagt      780

tcgaatttgt cgttgatgaa gatgaatttt ctggcgataa agatgatgaa gcttttttta      840

tgaatttatc tgaagctgat gcagcttttc tcaaggtatt tgatgaaacc gtacctccca      900

aaaaagctaa ggggtga                                                     917


<210> 1008
<211> 255
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Kis antitoxin

<400> 1008
cataccaccc gactgaagag ggttggcggc tcagttatgc tgaccgtccc accggcactg       60

ctgaatgcgc tgtctctggg cacagataat gaagttggca tggtcattga taatggccgg      120

ctgattgttg agccgtacag acgcccgcaa tattcactgg ctgagctact ggcacagtgt      180

gatccgaatg ctgaaatatc agctgaagaa cgagaatggc tggatgcacc ggcgactggt      240

caggaggaaa tctga                                                       255


<210> 1009
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> RBS (low copy)

<400> 1009
gctggaacag gtgg                                                         14


<210> 1010
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> RBS (medium copy)

<400> 1010
tccggaagac tagg                                                         14


<210> 1011
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SR36

<400> 1011
tagaactgat gcaaaaagtg ctcgacgaag gcacacagat gtgtaggctg gagctgcttc       60


<210> 1012
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SR38

<400> 1012
gtttcgtaat tagatagcca ccggcgcttt aatgcccgga catatgaata tcctccttag       60


<210> 1013
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SR33

<400> 1013
caacacgttt cctgaggaac catgaaacag tatttagaac tgatgcaaaa ag               52


<210> 1014
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SR43

<400> 1014
atatcgtcgc agcccacagc aacacgtttc ctgagg                                 36


<210> 1015
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> SR44

<400> 1015
aagaatttaa cggagggcaa aaaaaaccga cgcacactgg cgtcggc                     47


<210> 1016
<211> 967
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Wild-type clbA

<400> 1016
caaatatcac ataatcttaa catatcaata aacacagtaa agtttcatgt gaaaaacatc       60

aaacataaaa tacaagctcg gaatacgaat cacgctatac acattgctaa caggaatgag      120

attatctaaa tgaggattga tatattaatt ggacatacta gtttttttca tcaaaccagt      180

agagataact tccttcacta tctcaatgag gaagaaataa aacgctatga tcagtttcat      240

tttgtgagtg ataaagaact ctatatttta agccgtatcc tgctcaaaac agcactaaaa      300

agatatcaac ctgatgtctc attacaatca tggcaattta gtacgtgcaa atatggcaaa      360

ccatttatag tttttcctca gttggcaaaa aagatttttt ttaacctttc ccatactata      420

gatacagtag ccgttgctat tagttctcac tgcgagcttg gtgtcgatat tgaacaaata      480

agagatttag acaactctta tctgaatatc agtcagcatt tttttactcc acaggaagct      540

actaacatag tttcacttcc tcgttatgaa ggtcaattac ttttttggaa aatgtggacg      600

ctcaaagaag cttacatcaa atatcgaggt aaaggcctat ctttaggact ggattgtatt      660

gaatttcatt taacaaataa aaaactaact tcaaaatata gaggttcacc tgtttatttc      720

tctcaatgga aaatatgtaa ctcatttctc gcattagcct ctccactcat cacccctaaa      780

ataactattg agctatttcc tatgcagtcc caactttatc accacgacta tcagctaatt      840

cattcgtcaa atgggcagaa ttgaatcgcc acggataatc tagacacttc tgagccgtcg      900

ataatattga ttttcatatt ccgtcggtgg tgtaagtatc ccgcataatc gtgccattca      960

catttag                                                                967


<210> 1017
<211> 424
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> clbA knockout

<400> 1017
ggatgggggg aaacatggat aagttcaaag aaaaaaaccc gttatctctg cgtgaaagac       60

aagtattgcg catgctggca caaggtgatg agtactctca aatatcacat aatcttaaca      120

tatcaataaa cacagtaaag tttcatgtga aaaacatcaa acataaaata caagctcgga      180

atacgaatca cgctatacac attgctaaca ggaatgagat tatctaaatg aggattgatg      240

tgtaggctgg agctgcttcg aagttcctat actttctaga gaataggaac ttcggaatag      300

gaacttcgga ataggaacta aggaggatat tcatatgtcg tcaaatgggc agaattgaat      360

cgccacggat aatctagaca cttctgagcc gtcgataata ttgattttca tattccgtcg      420

gtgg                                                                   424


<210> 1018
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Master Sequence


<220>
<221> modified_base
<222> (13)..(15)
<223> a, c, g or t

<220>
<221> modified_base
<222> (18)..(20)
<223> a, c, g or t

<400> 1018
tctagagaaa gannngannn actagatg                                          28


<210> 1019
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61100

<400> 1019
tctagagaaa gaggggacaa actagatg                                          28


<210> 1020
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61101

<400> 1020
tctagagaaa gacaggaccc actagatg                                          28


<210> 1021
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61102

<400> 1021
tctagagaaa gatccgatgt actagatg                                          28


<210> 1022
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61103

<400> 1022
tctagagaaa gattagacaa actagatg                                          28


<210> 1023
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61104

<400> 1023
tctagagaaa gaagggacag actagatg                                          28


<210> 1024
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61105

<400> 1024
tctagagaaa gacatgacgt actagatg                                          28


<210> 1025
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61106

<400> 1025
tctagagaaa gataggagac actagatg                                          28


<210> 1026
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61107

<400> 1026
tctagagaaa gaagagactc actagatg                                          28


<210> 1027
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61108

<400> 1027
tctagagaaa gacgagatat actagatg                                          28


<210> 1028
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61109

<400> 1028
tctagagaaa gactggagac actagatg                                          28


<210> 1029
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61110

<400> 1029
tctagagaaa gaggcgaatt actagatg                                          28


<210> 1030
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61111

<400> 1030
tctagagaaa gaggcgatac actagatg                                          28


<210> 1031
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61112

<400> 1031
tctagagaaa gaggtgacat actagatg                                          28


<210> 1032
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61113

<400> 1032
tctagagaaa gagtggaaaa actagatg                                          28


<210> 1033
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61114

<400> 1033
tctagagaaa gatgagaaga actagatg                                          28


<210> 1034
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61115

<400> 1034
tctagagaaa gaagggatac actagatg                                          28


<210> 1035
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61116

<400> 1035
tctagagaaa gacatgaggc actagatg                                          28


<210> 1036
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61117

<400> 1036
tctagagaaa gacatgagtt actagatg                                          28


<210> 1037
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61118

<400> 1037
tctagagaaa gagacgaatc actagatg                                          28


<210> 1038
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61119

<400> 1038
tctagagaaa gatttgatat actagatg                                          28


<210> 1039
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61120

<400> 1039
tctagagaaa gacgcgagaa actagatg                                          28


<210> 1040
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61121

<400> 1040
tctagagaaa gagacgagtc actagatg                                          28


<210> 1041
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61122

<400> 1041
tctagagaaa gagaggagcc actagatg                                          28


<210> 1042
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61123

<400> 1042
tctagagaaa gagatgacta actagatg                                          28


<210> 1043
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61124

<400> 1043
tctagagaaa gagccgacat actagatg                                          28


<210> 1044
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61125

<400> 1044
tctagagaaa gagccgagtt actagatg                                          28


<210> 1045
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61126

<400> 1045
tctagagaaa gaggtgactc actagatg                                          28


<210> 1046
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61127

<400> 1046
tctagagaaa gagtggaact actagatg                                          28


<210> 1047
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61128

<400> 1047
tctagagaaa gataggactc actagatg                                          28


<210> 1048
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61129

<400> 1048
tctagagaaa gattggacgt actagatg                                          28


<210> 1049
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61130

<400> 1049
tctagagaaa gaaacgacat actagatg                                          28


<210> 1050
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> BBa_J61131

<400> 1050
tctagagaaa gaaccgaatt actagatg                                          28


<210> 1051
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> polypeptide linker

<400> 1051
Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Asp Ala 
1               5                   10                  15      


Lys Lys Asp Asp Ala Lys Lys Asp Ala Ser 
            20                  25      


<210> 1052
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> polypeptide linker

<400> 1052
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 1053
<211> 197
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1053
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 1054
<211> 306
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1054
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210> 1055
<211> 197
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1055
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 1056
<211> 313
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1056
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      


Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         


Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             


Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 


Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 


Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     


Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         


Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             


Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 


Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 


His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     


Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         


Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             


Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 


Ala Cys Val Pro Cys Arg Val Arg Ser 
305                 310             


<210> 1057
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1057
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 1058
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1058
Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210> 1059
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1059
Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu Ser Leu Ile Ser Pro 
1               5                   10                  15      


Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro 
            20                  25                  30          


Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp 
        35                  40                  45              


Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg 
    50                  55                  60                  


Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser 
65                  70                  75                  80  


Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu 
                85                  90                  95      


Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn 
            100                 105                 110         


Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly 
        115                 120                 125             


Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe 
    130                 135                 140                 


Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp 
145                 150                 155                 160 


Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala 
                165                 170                 175     


Leu 
    


<210> 1060
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1060
Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe Asn 
1               5                   10                  15      


Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly Ile 
            20                  25                  30          


Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser Gln 
        35                  40                  45              


Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp Gln 
    50                  55                  60                  


Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val Lys 
65                  70                  75                  80  


Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu Thr 
                85                  90                  95      


Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His Glu 
            100                 105                 110         


Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly Lys 
        115                 120                 125             


Arg Lys Arg Ser Gln Met Leu Phe Arg Gly 
    130                 135             


<210> 1061
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1061
Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser Asn 
1               5                   10                  15      


Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro Ala 
            20                  25                  30          


Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys Lys 
        35                  40                  45              


Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn Leu 
    50                  55                  60                  


Leu Lys Ala Val Ser Lys Glu Arg Ser 
65                  70              


<210> 1062
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1062
Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210> 1063
<211> 594
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1063
aggaacctgc ctgtggcaac accagaccct gggatgttcc cttgcttaca tcattcccag       60

aacctgttgc gtgcggtgtc taacatgctg cagaaagcca ggcagacgct ggaattctac      120

ccatgcactt ccgaagagat agatcatgaa gacattacga aagacaaaac ctcaacggtt      180

gaagcatgct tacctctgga attgactaag aatgaatcgt gcttaaactc aagagagacc      240

agtttcatca ctaatggctc ttgcttagcg tcgcgcaaga ccagcttcat gatggcgctc      300

tgcctaagta gcatctacga ggacctcaaa atgtaccaag ttgaatttaa aactatgaat      360

gccaaacttc taatggaccc aaaaagacag atatttttag atcagaatat gcttgcggtt      420

attgacgaac tcatgcaggc attgaatttt aattccgaga cggtgccaca aaaaagttct      480

ttggaggagc cggactttta caagacaaaa atcaagctgt gcatacttct tcacgcattc      540

agaatacggg ccgttacgat cgatcgcgtc atgtcgtatc ttaatgcgag ctga            594


<210> 1064
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1064
atctgggaac tgaaaaaaga tgtttatgta gttgaactgg attggtaccc ggatgcaccc       60

ggtgagatgg tggttttgac ctgcgacacg ccggaagaag atggcataac gtggaccctg      120

gatcaaagct ctgaagttct gggttcaggt aagacattga cgatccaagt aaaagaattt      180

ggcgacgcag gtcagtacac ctgccacaaa ggtggcgaag ttctgtcgca ctcactcctg      240

ctcctgcaca aaaaagagga tggcatctgg agtactgata tcctaaagga tcaaaaagaa      300

cctaaaaaca aaacgttctt gcgctgtgaa gcgaagaact atagtggtcg ctttacgtgc      360

tggtggttga ctaccatttc caccgatttg accttttctg ttaagagttc gcgcggctcg      420

tcagatccgc agggcgttac ttgcggtgcg gcgacgctgt cagctgagag agttcgtggg      480

gacaacaaag agtacgaata tagtgtagaa tgtcaagagg attcggcgtg cccggcagca      540

gaggagtctc tccccattga agttatggtg gacgcagtgc ataaactgaa atatgagaat      600

tacacatcaa gcttttttat tcgcgatatc atcaaaccgg atcctccaaa aaatctgcaa      660

ctaaagcccc tgaaaaattc gcgccaagtt gaggtgagct gggaatatcc ggatacttgg      720

tcgacaccgc attcttattt ctcactgacc ttctgcgttc aggttcaagg taaatcaaaa      780

cgagaaaaaa aggatcgcgt ctttaccgac aaaacgtctg ctactgtaat ctgccgcaag      840

aatgcgtcaa tttctgtacg tgcgcaagat cgctactact ctagtagttg gtctgaatgg      900

gcttcagtgc catgctcctg atga                                             924


<210> 1065
<211> 594
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1065
cgtaaccttc cggtggccac gccagatccg ggcatgttcc cgtgcttaca ccattcccag       60

aatctgctgc gcgctgtgag taatatgctg cagaaggcga gacaaacttt ggaattttac      120

ccgtgcactt cggaggagat tgaccatgag gatatcacaa aagacaaaac cagtacagtg      180

gaagcctgcc tgccccttga actgactaaa aatgagagtt gtttaaattc acgcgaaacc      240

agcttcatta ctaacggaag ctgcttagca tcgcggaaaa ccagttttat gatggccctt      300

tgcctttcat ctatttacga ggaccttaaa atgtatcaag ttgaatttaa gactatgaac      360

gcgaaactgc taatggatcc caagcgacaa atctttcttg atcaaaatat gttggctgtt      420

attgatgaac tgatgcaagc cctgaatttt aactcagaaa ccgtacctca gaaatcgagt      480

ttagaagaac ccgatttcta caaaactaaa atcaagttgt gtatcctttt acatgccttc      540

cggattcggg ccgtcactat tgatcgcgtg atgtcgtact tgaatgcctc ctaa            594


<210> 1066
<211> 942
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1066
atgtgggaat tggaaaaaga cgtgtatgtt gttgaagttg actggactcc ggacgcgcct       60

ggtgaaactg ttaatctgac ttgtgataca ccggaggaag atgatataac ttggactagc      120

gatcaacgac acggcgtaat cggctctggt aagactttga ccattactgt gaaggaattc      180

ttggatgcgg ggcaatatac gtgtcataaa ggcggcgaga cgctgtcaca ctctcacctg      240

ttgttacata aaaaagagaa tggtatatgg tctacggaga tcttgaaaaa ctttaaaaac      300

aaaacttttt tgaagtgtga ggctccaaac tattctggtc gctttacctg tagttggttg      360

gtgcaacgta acatggatct caaatttaac ataaagtcgt cttcgtcttc tcccgatagc      420

cgagcggtta cctgtggcat ggctagtttg tcggcggaga aggtgacctt ggatcaacgt      480

gattatgaaa aatatagcgt ttcgtgccaa gaggacgtta cgtgccctac cgctgaagag      540

actttgccga ttgaattggc actggaagca cgacaacaaa ataaatacga gaattactca      600

actagtttct tcatccgaga tatcataaaa ccggaccccc cgaagaatct gcaaatgaaa      660

ccgcttaaaa attcacaggt agaggtttcg tgggagtacc cggatagttg gtctacgcct      720

cattcgtatt ttagcctgaa atttttcgtt cgaatacagc gaaaaaaaga gaagatgaaa      780

gaaactgaag aagggtgtaa ccaaaaaggt gcatttctgg tggagaaaac tagcaccgag      840

gttcaatgca aaggcggtaa cgtgtgcgta caagctcaag accgttatta taacagtagc      900

tgttctaaat gggcttgcgt gccctgccgc gtgagatcat ga                         942


<210> 1067
<211> 345
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1067
aattgggtta atgttatatc tgatttgaaa aaaatagagg atctgattca atcaatgcac       60

atagatgcga ctctgtatac tgagagcgat gtgcacccga gttgcaaagt tactgctatg      120

aaatgttttc tgctggagct gcaagttatc tctctggaga gtggtgatgc gtctattcac      180

gatactgttg agaatctgat tattctggct aataactcgc tgtcaagtaa tgggaatgtt      240

acggaatctg gctgtaagga gtgtgaagaa ttagaagaaa aaaatattaa agagtttctg      300

cagagttttg tgcacattgt tcagatgttt atcaatacta gctga                      345


<210> 1068
<211> 384
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1068
gcaccggccc gcagcccatc accgtcaact caaccttggg aacatgtaaa tgctattcaa       60

gaagctcgcc gcctgttgaa tttgagtcgc gatactgcag cagagatgaa tgagactgta      120

gaggtgattt cagaaatgtt tgacctgcag gagccgactt gtttgcaaac tcgcctggag      180

ctgtacaaac aaggcctgcg tggctcgctg actaaactga aaggtcctct gacgatgatg      240

gcttctcatt ataaacaaca ctgcccgcct actccggaga cgtcttgcgc gacccagata      300

attacttttg aatcttttaa agagaatctg aaagactttc tgctggttat cccgtttgat      360

tgttgggaac cggttcaaga ataa                                             384


<210> 1069
<211> 534
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1069
ggtccgcaga gggaagaatt cccgcgcgat ttgagcctga tttcacctct tgctcaggct       60

gtccgctcct cttcgcgtac cccctcggat aaacctgtcg cgcacgtggt tgcgaacccg      120

caagcggaag ggcagctgca atggttaaac cgccgggcta atgcactgct ggctaatgga      180

gttgagttac gcgacaacca acttgtcgtt ccttcggaag ggctgtatct gatctattca      240

caggttctct ttaaagggca gggttgccca tcaacccacg tgctcctgac acacacgatc      300

agtcgtatcg cggtatccta tcagacgaaa gttaacctcc tgtcagcgat taaatcgccg      360

tgtcagagag aaactccaga gggtgcggaa gctaaaccgt ggtatgaacc tatttatctt      420

ggtggagttt tccagttgga aaaaggtgat agactgtcgg cagagatcaa tcgccctgat      480

tacctggatt tcgctgagtc gggtcaggtt tatttcggaa ttattgcact gtga            534


<210> 1070
<211> 417
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1070
caggatcctt acgttaaaga agcagagaat ctgaaaaaat actttaatgc aggccacagc       60

gatgtggcag ataatggcac gttattcctg ggcattctga aaaattggaa agaagaatct      120

gaccggaaga tcatgcaatc tcagatcgta tcattttatt tcaagttgtt taaaaacttc      180

aaggatgacc agtcgattca aaaatcagtg gaaacgatca aagaagatat gaacgttaag      240

ttcttcaact caaataaaaa aaaacgcgat gatttcgaaa aactgactaa ttattcggta      300

actgatttga atgttcagcg caaggcgatt catgaattga ttcaggttat ggcagaactg      360

tcgccagcgg caaaaacggg taaacgaaaa cgttctcaga tgttgtttcg tggttga         417


<210> 1071
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1071
gtgcccctga gccgcaccgt gcgttgtacg tgtatctcca tctcaaacca gccggtaaac       60

ccgcgtagtt tagaaaaact ggagattatc ccagccagcc agttttgccc gcgcgttgag      120

attattgcga ccatgaagaa aaaaggggaa aaacgttgcc ttaatccaga aagtaaggct      180

atcaaaaacc tgttgaaagc tgtctcgaaa gagcgttcct aa                         222


<210> 1072
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1072
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Val Pro Leu Ser Arg Thr Val Arg Cys Thr 
            20                  25                  30          


Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys 
        35                  40                  45              


Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile 
    50                  55                  60                  


Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser 
65                  70                  75                  80  


Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
                85                  90                  95  


<210> 1073
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1073
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
                85                  90                  


<210> 1074
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1074
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Val Pro Leu Ser Arg Thr Val Arg Cys 
        35                  40                  45              


Thr Cys Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu 
    50                  55                  60                  


Lys Leu Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile 
65                  70                  75                  80  


Ile Ala Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu 
                85                  90                  95      


Ser Lys Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
            100                 105                 110         


<210> 1075
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1075
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210> 1076
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1076
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Thr Pro Val Val Arg Lys Gly Arg Cys Ser Cys 
            20                  25                  30          


Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp Leu 
        35                  40                  45              


Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile Ala 
    50                  55                  60                  


Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala Asp 
65                  70                  75                  80  


Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys Lys 
                85                  90                  95      


Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys Val 
            100                 105                 110         


Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 


<210> 1077
<211> 142
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1077
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Thr Pro Val Val Arg Lys Gly Arg Cys 
        35                  40                  45              


Ser Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys 
    50                  55                  60                  


Asp Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile 
65                  70                  75                  80  


Ile Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser 
                85                  90                  95      


Ala Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln 
            100                 105                 110         


Lys Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu 
        115                 120                 125             


Lys Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
    130                 135                 140         


<210> 1078
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1078
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Thr Leu Val Ile Arg Asn Ala Arg Cys Ser Cys 
            20                  25                  30          


Ile Ser Thr Ser Arg Gly Thr Ile His Tyr Lys Ser Leu Lys Asp Leu 
        35                  40                  45              


Lys Gln Phe Ala Pro Ser Pro Asn Cys Asn Lys Thr Glu Ile Ile Ala 
    50                  55                  60                  


Thr Leu Lys Asn Gly Asp Gln Thr Cys Leu Asp Pro Asp Ser Ala Asn 
65                  70                  75                  80  


Val Lys Lys Leu Met Lys Glu Trp Glu Lys Lys Ile Ser Gln Lys Lys 
                85                  90                  95      


Lys Gln Lys Arg Gly Lys Lys His Gln Lys Asn Met Lys Asn Arg Lys 
            100                 105                 110         


Pro Lys Thr Pro Gln Ser Arg Arg Arg Ser Arg Lys Thr Thr 
        115                 120                 125     


<210> 1079
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1079
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Thr Leu Val Ile Arg Asn Ala Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Ser Arg Gly Thr Ile His Tyr Lys Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Asn Cys Asn Lys Thr Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Asp Gln Thr Cys Leu Asp Pro Asp Ser Ala 
65                  70                  75                  80  


Asn Val Lys Lys Leu Met Lys Glu Trp Glu Lys Lys Ile Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Arg Gly Lys Lys His Gln Lys Asn Met Lys Asn Arg 
            100                 105                 110         


Lys Pro Lys Thr Pro Gln Ser Arg Arg Arg Ser Arg Lys Thr Thr 
        115                 120                 125         


<210> 1080
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1080
Met Asn Asn Asn Asp Leu Phe Gln Ala Ser Arg Arg Arg Phe Leu Ala 
1               5                   10                  15      


Gln Leu Gly Gly Leu Thr Val Ala Gly Met Leu Gly Pro Ser Leu Leu 
            20                  25                  30          


Thr Pro Arg Arg Ala Thr Ala Thr Leu Val Ile Arg Asn Ala Arg Cys 
        35                  40                  45              


Ser Cys Ile Ser Thr Ser Arg Gly Thr Ile His Tyr Lys Ser Leu Lys 
    50                  55                  60                  


Asp Leu Lys Gln Phe Ala Pro Ser Pro Asn Cys Asn Lys Thr Glu Ile 
65                  70                  75                  80  


Ile Ala Thr Leu Lys Asn Gly Asp Gln Thr Cys Leu Asp Pro Asp Ser 
                85                  90                  95      


Ala Asn Val Lys Lys Leu Met Lys Glu Trp Glu Lys Lys Ile Ser Gln 
            100                 105                 110         


Lys Lys Lys Gln Lys Arg Gly Lys Lys His Gln Lys Asn Met Lys Asn 
        115                 120                 125             


Arg Lys Pro Lys Thr Pro Gln Ser Arg Arg Arg Ser Arg Lys Thr Thr 
    130                 135                 140                 


<210> 1081
<211> 285
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1081
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctgtgcccc tgagccgcac cgtgcgttgt acgtgtatct ccatctcaaa ccagccggta      120

aacccgcgta gtttagaaaa actggagatt atcccagcca gccagttttg cccgcgcgtt      180

gagattattg cgaccatgaa gaaaaaaggg gaaaaacgtt gccttaatcc agaaagtaag      240

gctatcaaaa acctgttgaa agctgtctcg aaagagcgtt cctaa                      285


<210> 1082
<211> 297
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1082
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctatcccac tggctcgcac agtccgctgt aattgcatcc acatcgatga cggtcctgtg      120

cgtatgcgtg caatcggtaa acttgaaatt atccctgcct ccttatcgtg tccccgcgta      180

gagattatcg ccacgatgaa gaaaaacgat gaacagcgtt gtcttaaccc agagagcaaa      240

actatcaaaa acctgatgaa ggcttttagt caaaagcgca gtaagcgcgc accataa         297


<210> 1083
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1083
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctacacccg tagtgcgtaa agggcgctgc agttgcatct cgactaacca ggggacaatc      120

cacctgcagt cgctgaaaga tttgaagcag tttgcaccga gccctagttg tgaaaaaatc      180

gagatcatcg ctacattaaa gaacggcgtc caaacatgtc ttaaccccga ctcagcagat      240

gttaaagaac ttattaagaa atgggagaag caggtaagtc agaaaaagaa acagaaaaat      300

ggcaagaaac atcagaaaaa gaaagtctta aaggttcgta aatcgcagcg ttctcgtcaa      360

aagaagacga cgtaa                                                       375


<210> 1084
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1084
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctacgctgg tgatccgtaa cgcccgctgt tcatgcatca gcacttctcg tggaaccatc      120

cactataaat cattaaagga cttgaaacag tttgcacctt caccaaattg taacaagacg      180

gaaattattg ctactctgaa aaacggagat caaacttgcc tggaccccga ctctgcaaac      240

gtgaagaagc tgatgaagga atgggaaaaa aaaatctctc aaaagaaaaa gcaaaagcgc      300

ggtaagaaac atcagaagaa catgaagaat cgtaagccaa agacccctca gtcgcgccgt      360

cgttctcgta agacgacgta a                                                381


<210> 1085
<211> 284
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1085
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctgtgcccc tgagccgcac cgtgcgttgt acgtgtatct ccatctcaaa ccagccggta      120

aacccgcgta gtttagaaaa actggagatt atcccagcca gccagttttg cccgcgcgtt      180

gagattattg cgaccatgaa gaaaaaaggg gaaaaacgtt gccttaatcc agaaagtaag      240

gctatcaaaa acctgttgaa agctgtctcg aaagagcgtt ccta                       284


<210> 1086
<211> 1204
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1086
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaaataag tttatcaaaa taaaaggagg taatatatga      780

agcagagcac catcgcgctt gccctgctgc cgttgctttt cacgcctgtc accaaggcta      840

tcccactggc tcgcacagtc cgctgtaatt gcatccacat cgatgacggt cctgtgcgta      900

tgcgtgcaat cggtaaactt gaaattatcc ctgcctcctt atcgtgtccc cgcgtagaga      960

ttatcgccac gatgaagaaa aacgatgaac agcgttgtct taacccagag agcaaaacta     1020

tcaaaaacct gatgaaggct tttagtcaaa agcgcagtaa gcgcgcacca taaaacgatt     1080

ggtaaacccg gtgaacgcat gagaaagccc ccggaagatc accttccggg ggctttttta     1140

ttgcgcggac caaaacgaaa aaagacgctc gaaagcgtct cttttctgga atttggtacc     1200

gagg                                                                  1204


<210> 1087
<211> 375
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1087
atgaagcaga gcaccatcgc gcttgccctg ctgccgttgc ttttcacgcc tgtcaccaag       60

gctacacccg tagtgcgtaa agggcgctgc agttgcatct cgactaacca ggggacaatc      120

cacctgcagt cgctgaaaga tttgaagcag tttgcaccga gccctagttg tgaaaaaatc      180

gagatcatcg ctacattaaa gaacggcgtc caaacatgtc ttaaccccga ctcagcagat      240

gttaaagaac ttattaagaa atgggagaag caggtaagtc agaaaaagaa acagaaaaat      300

ggcaagaaac atcagaaaaa gaaagtctta aaggttcgta aatcgcagcg ttctcgtcaa      360

aagaagacga cgtaa                                                       375


<210> 1088
<211> 1288
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1088
ccaggataca tagattacca caactccgag cccttccacc ttaagaccca ctttcacatt       60

taagttgttt ttctaatccg catatgatca attcaaggcc gaataagaag gctggctctg      120

caccttggtg atcaaataat tcgatagctt gtcgtaataa tggcggcata ctatcagtag      180

taggtgtttc cctttcttct ttagcgactt gatgctcttg atcttccaat acgcaaccta      240

aagtaaaatg ccccacagcg ctgagtgcat ataatgcatt ctctagtgaa aaaccttgtt      300

ggcataaaaa ggctaattga ttttcgagag tttcatactg tttttctgta ggccgtgtac      360

ctaaatgtac ttttgctcca tcgcgatgac ttagtaaagc acatctaaaa cttttagcgt      420

tattacgtaa aaaatcttgc cagctttccc cttctaaagg gcaaaagtga gtatggtgcc      480

tatctaacat ctcaatggct aaggcgtcga gcaaagcccg cttatttttt acatgccaat      540

acaatgtagg ctgctctaca cctagcttct gggcgagttt acgggttgtt aaaccttcga      600

ttccgacctc attaagcagc tctaatgcgc tgttaatcac tttactttta tctaatctag      660

acatcattaa ttcctaattt ttgttgacac tctatcattg atagagttat tttaccactc      720

cctatcagtg atagagaaaa gtgaaataag tttatcaaaa taaaaggagg taatatatga      780

agcagagcac catcgcgctt gccctgctgc cgttgctttt cacgcctgtc accaaggcta      840

cgctggtgat ccgtaacgcc cgctgttcat gcatcagcac ttctcgtgga accatccact      900

ataaatcatt aaaggacttg aaacagtttg caccttcacc aaattgtaac aagacggaaa      960

ttattgctac tctgaaaaac ggagatcaaa cttgcctgga ccccgactct gcaaacgtga     1020

agaagctgat gaaggaatgg gaaaaaaaaa tctctcaaaa gaaaaagcaa aagcgcggta     1080

agaaacatca gaagaacatg aagaatcgta agccaaagac ccctcagtcg cgccgtcgtt     1140

ctcgtaagac gacgtaaaac gattggtaaa cccggtgaac gcatgagaaa gcccccggaa     1200

gatcaccttc cgggggcttt tttattgcgc ggaccaaaac gaaaaaagac gctcgaaagc     1260

gtctcttttc tggaatttgg taccgagg                                        1288


<210> 1089
<211> 858
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1089
aaacaatcga ccatcgcatt ggcgctgctt cctctattgt tcacaccggt gacaaaggca       60

gtcgactata aggatgacga cgacaagcaa ttgggcggtg gccaccgtcg tttggacaag      120

gtggaggagg aagtcaactt gcatgaagat tttgtattta tcaagaaatt aaagcgttgt      180

aacaagggtg aagggagctt gagtttactt aactgtgaag aaatgcgccg ccaattcgag      240

gacttggtta aggacattac ccttaacaag gaagaaaaga aagagaacag cttcgaaatg      300

cagcgtggcg atgaagaccc ccagatcgcg gcacatgtcg tttccgaggc aaattcgaat      360

gctgcttcag tcttacaatg ggcgaaaaag ggctactaca cgatgaagtc aaacttagtg      420

atgcttgaaa atggcaagca attaaccgtg aagcgcgaag gattgtatta tgtctacacc      480

caagtaacat tttgctccaa tcgcgaaccg tcgtcgcagc gccctttcat cgttggtttg      540

tggttgaagc cgagctccgg ttccgagcgt attcttttga aagccgcaaa cacccacagc      600

agctcgcagc tgtgtgaaca gcagagcgtc cacctgggcg gcgtatttga attgcaagcg      660

ggagcgtcag ttttcgttaa tgtgactgag gcttctcaag ttatccatcg tgtcggtttc      720

tccagcttcg gcttactgaa gttaaagggc gagctcaatt cgaagcttga aggtaagcct      780

atccctaacc ctctcctcgg cctcgattct acggatccga attcgagctc cgtcgaccat      840

caccatcacc accactga                                                    858


<210> 1090
<211> 791
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1090
tgactagtaa acaatcgacc atcgcattgg cgctgcttcc tctattgttc acaccggtga       60

caaaggcagt cgactataag gatgacgacg acaagcaatt gggcggtggc atgcaacgtg      120

gcgatgagga cccgcaaatt gccgcgcatg ttgtgtccga agcgaactcc aatgccgcat      180

ccgtcctgca atgggctaag aaaggctatt acacgatgaa atcaaacctg gttatgcttg      240

agaacggaaa gcagcttaca gtcaagcgtg agggcctgta ttacgtctac acccaagtta      300

ccttttgctc taaccgtgag cccagcagcc aacgcccttt tattgtaggc ctgtggttaa      360

agccctcgtc gggttctgaa cgcattcttc tgaaagctgc gaatacgcac tctagtagcc      420

agctgtgtga gcaacaatct gtccatcttg gtggagtttt tgagttacaa gctggagcat      480

ctgtgttcgt gaatgtaacg gaagcatctc aagttatcca ccgtgtaggc ttctcatctt      540

ttggtttatt aaaattaaag ggcgagctca attcgaagct tgaaggtaag cctatcccta      600

accctctcct cggcctcgat tctacggatc cgaattcgag ctccgtcgac catcaccatc      660

accaccactg agcatgctaa tcagccgtgg aattcggtct caggaggatc agttctggac      720

cagcgagctg tgctgcgact cgtggcgtaa tcatggtcat agctgtttcc tgtgtgaaat      780

tgttatccgc t                                                           791


<210> 1091
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1091
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly His Arg Arg Leu Asp Lys Val Glu Glu Glu Val 
        35                  40                  45              


Asn Leu His Glu Asp Phe Val Phe Ile Lys Lys Leu Lys Arg Cys Asn 
    50                  55                  60                  


Lys Gly Glu Gly Ser Leu Ser Leu Leu Asn Cys Glu Glu Met Arg Arg 
65                  70                  75                  80  


Gln Phe Glu Asp Leu Val Lys Asp Ile Thr Leu Asn Lys Glu Glu Lys 
                85                  90                  95      


Lys Glu Asn Ser Phe Glu Met Gln Arg Gly Asp Glu Asp Pro Gln Ile 
            100                 105                 110         


Ala Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu 
        115                 120                 125             


Gln Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met 
    130                 135                 140                 


Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr 
145                 150                 155                 160 


Val Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln 
                165                 170                 175     


Arg Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu 
            180                 185                 190         


Arg Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys 
        195                 200                 205             


Glu Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly 
    210                 215                 220                 


Ala Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg 
225                 230                 235                 240 


Val Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Lys Gly Glu Leu Asn 
                245                 250                 255     


Ser Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
            260                 265                 270         


Ser Thr Asp Pro Asn Ser Ser Ser Val Asp His His His His His His 
        275                 280                 285             


<210> 1092
<211> 223
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1092
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Met Gln Arg Gly Asp Glu Asp Pro Gln Ile Ala 
        35                  40                  45              


Ala His Val Val Ser Glu Ala Asn Ser Asn Ala Ala Ser Val Leu Gln 
    50                  55                  60                  


Trp Ala Lys Lys Gly Tyr Tyr Thr Met Lys Ser Asn Leu Val Met Leu 
65                  70                  75                  80  


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Glu Gly Leu Tyr Tyr Val 
                85                  90                  95      


Tyr Thr Gln Val Thr Phe Cys Ser Asn Arg Glu Pro Ser Ser Gln Arg 
            100                 105                 110         


Pro Phe Ile Val Gly Leu Trp Leu Lys Pro Ser Ser Gly Ser Glu Arg 
        115                 120                 125             


Ile Leu Leu Lys Ala Ala Asn Thr His Ser Ser Ser Gln Leu Cys Glu 
    130                 135                 140                 


Gln Gln Ser Val His Leu Gly Gly Val Phe Glu Leu Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Val Phe Val Asn Val Thr Glu Ala Ser Gln Val Ile His Arg Val 
                165                 170                 175     


Gly Phe Ser Ser Phe Gly Leu Leu Lys Leu Lys Gly Glu Leu Asn Ser 
            180                 185                 190         


Lys Leu Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
        195                 200                 205             


Thr Asp Pro Asn Ser Ser Ser Val Asp His His His His His His 
    210                 215                 220             


<210> 1093
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1093
His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210> 1094
<211> 1251
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1094
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg caaggaactg      120

aaagtcaccc agcctgagaa gtctgtctca gtagcggcag gtgacagcac ggtgcttaac      180

tgcacgctta cttcactgct gccggtaggt cccattaaat ggtatcgtgg cgtgggccaa      240

agtcgtttgt taatctactc ctttacgggt gagcactttc cgcgcgtaac taatgtaagc      300

gacgcaacaa aacgtaacaa catggatttc agcattcgca tctcaaacgt cactcccgag      360

gatgctggga cttactactg cgtaaaattt cagaaaggcc cctcagagcc cgatacagaa      420

atccaatcag gaggcggcac agaagtctac gttctggcaa aaccctctcc ccctgaagtc      480

tccggtccag cagatcgtgg cattcctgac caaaaagtaa atttcacgtg caaatcgcac      540

gggtttagcc cacgcaacat cacactgaag tggtttaaag atggtcagga acttcatcac      600

cttgagacta ccgtgaaccc gtccggtaaa aacgtttcct acaatatctc gtccactgtg      660

cgtgttgtat tgaatagcat ggacgttcac agcaaggtga tctgtgaagt cgctcacatt      720

acccttgacc gttcaccatt gcgtggtatc gcgaacctga gcaatttcat ccgtgtcagc      780

ccgacggtta aggttactca gcagtcccca acatcgatga accaggtaaa tctgacgtgt      840

cgtgcagaac gtttttaccc tgaagacctg cagttgattt ggctggagaa cgggaacgtc      900

tcgcgcaatg acacacccaa aaatctgaca aagaatactg acggtacgta caattataca      960

tcactgtttc ttgtgaactc ctccgcccat cgcgaggacg tagtctttac atgtcaagtc     1020

aagcacgatc agcagcccgc gatcacccgt aatcacacag ttctgggcct ggctcactca     1080

tccgatcagg gatcaatgca aacatttccg ggaaacaatg caacccacaa ctggaataag     1140

ggcgagctca attcgaagct tgaaggtaag cctatcccta accctctcct cggcctcgat     1200

tctacggatc cgaattcgag ctccgtcgac catcaccatc accaccactg a              1251


<210> 1095
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1095
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggtggtag cgaagaagaa      120

ctgcagatta tccaaccgga caaatctgtt ctggtggctg cgggtgaaac ggctactttg      180

cgctgcacaa tcacctcgct gtttccagtc ggaccaatcc aatggttccg tggtgcggga      240

ccgggtcgcg tgttgatcta caatcagcgt caaggccctt tcccccgtgt tactactgtc      300

tccgatacaa caaagcgcaa caacatggac ttttccatcc gtatcgggaa tatcacaccg      360

gccgacgcgg gaacctatta ttgcatcaag tttcgcaagg gatctccaga cgatgttgaa      420

tttaagagcg gggctggaac tgagctgtcc gtgcgtgcaa aaccttcggg cagcggcgag      480

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc      540

ggtcatcatc accatcacca ttga                                             564


<210> 1096
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1096
gaagaagaac tgcagattat ccaaccggac aaatctgttc tggtggctgc gggtgaaacg       60

gctactttgc gctgcacaat cacctcgctg tttccagtcg gaccaatcca atggttccgt      120

ggtgcgggac cgggtcgcgt gttgatctac aatcagcgtc aaggcccttt cccccgtgtt      180

actactgtct ccgatacaac aaagcgcaac aacatggact tttccatccg tatcgggaat      240

atcacaccgg ccgacgcggg aacctattat tgcatcaagt ttcgcaaggg atctccagac      300

gatgttgaat ttaagagcgg ggctggaact gagctgtccg tgcgtgcaaa accttcg         357


<210> 1097
<211> 945
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1097
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggtggtag cgaggaggaa      120

gtgcaaatca ttcaacccga caaaagcgtt agtgtcgcgg cgggtgagtc cgccatcctg      180

cattgcacta tcacatccct gtttcccgta ggtcccattc aatggtttcg tggagccggt      240

ccggcgcgtg ttcttatcta caatcaacgc cagggaccct tcccgcgtgt tacaacgatc      300

agtgaaacta cccgtcgtga aaacatggac tttagcattt cgatctccaa cattacaccc      360

gctgacgcag ggacgtacta ctgcatcaag tttcgtaaag gatctccaga cactgagttt      420

aagtctggcg cagggacgga gttgtccgtg cgtgcgaaac cttctggcgg aggagggtcg      480

gggggcggtg gttctgaaga ggaagttcag attatccaac cagataaatc agtgtccgtg      540

gcggcgggag agtcagctat ccttcactgt acaatcacat cgttattccc tgtagggcca      600

attcagtggt tccgtggggc aggacccgca cgtgtcctta tctataatca gcgtcagggg      660

cccttcccac gtgttacgac aatttcagag actactcgcc gcgagaacat ggacttcagt      720

attagcatct cgaacattac cccggcggac gcgggaactt attactgtat caagtttcgt      780

aaaggctcgc cggacaccga gttcaaatcc ggggcaggca ctgagttgag cgtgcgtgcg      840

aaaccatcgg gcagcggcga gctcggtggc agtggtaagc ctatccctaa ccctctcctc      900

ggcctcgatt ctacgggatc cggtcatcat caccatcacc attga                      945


<210> 1098
<211> 1224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1098
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaggag gagttacaaa ttatccaacc agataagtct      120

gtcttggtcg cagccggaga aacggcgacg ttacgctgca caatcacctc actgttcccg      180

gtcggtccga ttcagtggtt ccgtggagct ggtccgggcc gtgtcttaat ttacaatcaa      240

cgtcaaggac cttttccacg cgtaacaact gtttctgaca caaccaaacg taacaatatg      300

gacttttcta ttcgtattgg caacattacg ccagccgatg caggtacata ctactgtatc      360

aaattccgta aaggtagtcc tgatgacgtt gagtttaaaa gcggcgcagg gacggagctt      420

tcagtgcgtg caaagcccag tgctagcgcg gcggcgccgc catgcccgcc atgccctgcg      480

cccgagttct tgggtgggcc ttcagtgttc ctttttcccc cgaaaccaaa agataccctg      540

atgatttcgc gcacccctga agttacttgt gtggttgttg acgtctcaca agaggaccca      600

gaggtacaat tcaactggta tgtggacgga gtagaggtgc ataacgccaa gactaagccc      660

cgtgaagagc agttcaattc tacataccgt gtagtttcgg ttttaacggt cttacaccaa      720

gattggttga acggaaagga atataagtgc aaggtgtcca ataagggact gccaagcagt      780

atcgaaaaaa caatctcaaa agcaaaggga caaccgcgtg agccccaggt ttacactctg      840

ccaccgtcgc aagaggagat gacgaagaat caggtgtcgt taacctgttt ggtcaaaggc      900

ttttatccaa gcgatatcgc agtggaatgg gaatcaaatg ggcagcctga aaataactat      960

aagacaaccc cgcctgtact tgattctgat ggatcttttt ttctttatag tcgcttaacc     1020

gtggataaat cccgttggca ggaaggtaat gtcttctcat gctcggttat gcacgaggcc     1080

cttcataacc attacactca gaagagcctt tctctgagtc cggggaaagg cagcggcgag     1140

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc     1200

ggtcatcatc accatcacca ttga                                            1224


<210> 1099
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1099
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaggag gagttacaaa ttatccaacc agataagtct      120

gtcttggtcg cagccggaga aacggcgacg ttacgctgca caatcacctc actgttcccg      180

gtcggtccga ttcagtggtt ccgtggagct ggtccgggcc gtgtcttaat ttacaatcaa      240

cgtcaaggac cttttccacg cgtaacaact gtttctgaca caaccaaacg taacaatatg      300

gacttttcta ttcgtattgg caacattacg ccagccgatg caggtacata ctactgtatc      360

aaattccgta aaggtagtcc tgatgacgtt gagtttaaaa gcggcgcagg gacggagctt      420

tcagtgcgtg caaagcccag tgctagcgcg gcggcgccgc catgcccgcc atgccctgcg      480

cccgagttct tgggtgggcc ttcagtgttc ctttttcccc cgaaaccaaa agataccctg      540

atgatttcgc gcacccctga agttacttgt gtggttgttg acgtctcaca agaggaccca      600

gaggtacaat tcaactggta tgtggacgga gtagaggtgc ataacgccaa gactaagccc      660

cgtgaagagc agttcaattc tacataccgt gtagtttcgg ttttaacggt cttacaccaa      720

gattggttga acggaaagga atataagtgc aaggtgtcca ataagggact gccaagcagt      780

atcgaaaaaa caatctcaaa agcaaaggga caaccgcgtg agccccaggt ttacactctg      840

ccaccgtcgc aagaggagat gacgaagaat caggtgtcgt taacctgttt ggtcaaaggc      900

ttttatccaa gcgatatcgc agtggaatgg gaatcaaatg ggcagcctga aaataactat      960

aagacaaccc cgcctgtact tgattctgat ggatcttttt ttctttatag tcgcttaacc     1020

gtggataaat cccgttggca ggaaggtaat gtcttctcat gctcggttat gcacgaggcc     1080

cttcataacc attacactca gaagagcctt tctctgagtc cggggaaa                  1128


<210> 1100
<211> 1128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1100
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaggag gagttacaaa ttatccaacc agataagtct      120

gtcttggtcg cagccggaga aacggcgacg ttacgctgca caatcacctc actgttcccg      180

gtcggtccga ttcagtggtt ccgtggagct ggtccgggcc gtgtcttaat ttacaatcaa      240

cgtcaaggac cttttccacg cgtaacaact gtttctgaca caaccaaacg taacaatatg      300

gacttttcta ttcgtattgg caacattacg ccagccgatg caggtacata ctactgtatc      360

aaattccgta aaggtagtcc tgatgacgtt gagtttaaaa gcggcgcagg gacggagctt      420

tcagtgcgtg caaagcccag tgctagcgcg gcggcgccgc catgcccgcc atgccctgcg      480

cccgagttct tgggtgggcc ttcagtgttc ctttttcccc cgaaaccaaa agataccctg      540

atgatttcgc gcacccctga agttacttgt gtggttgttg acgtctcaca agaggaccca      600

gaggtacaat tcaactggta tgtggacgga gtagaggtgc ataacgccaa gactaagccc      660

cgtgaagagc agttcaattc tacataccgt gtagtttcgg ttttaacggt cttacaccaa      720

gattggttga acggaaagga atataagtgc aaggtgtcca ataagggact gccaagcagt      780

atcgaaaaaa caatctcaaa agcaaaggga caaccgcgtg agccccaggt ttacactctg      840

ccaccgtcgc aagaggagat gacgaagaat caggtgtcgt taacctgttt ggtcaaaggc      900

ttttatccaa gcgatatcgc agtggaatgg gaatcaaatg ggcagcctga aaataactat      960

aagacaaccc cgcctgtact tgattctgat ggatcttttt ttctttatag tcgcttaacc     1020

gtggataaat cccgttggca ggaaggtaat gtcttctcat gctcggttat gcacgaggcc     1080

cttcataacc attacactca gaagagcctt tctctgagtc cggggaaa                  1128


<210> 1101
<211> 1191
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1101
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagcgaagaa gaggtgcaga tcatccaacc cgataaatcg      120

gtatctgtcg cagctgggga gtcggcgatt ttgcattgca ccattacatc tttgttccct      180

gttgggccta ttcaatggtt tcgcggggca ggtccggccc gcgtattgat ttataaccag      240

cgtcaaggac cgttcccccg tgttacaact atttcggaaa caacacgtcg tgaaaatatg      300

gatttctcga tctctatctc taacattact cccgccgatg cagggactta ttattgcatt      360

aaatttcgca aaggaagccc cgacacggag tttaagagtg gagcgggcac ggaattatcg      420

gtgcgcgcga aacccagtgc tagcgcggcg gcgccgccat gcccgccatg ccctgcgccc      480

gagttcttgg gtgggccttc agtgttcctt tttcccccga aaccaaaaga taccctgatg      540

atttcgcgca cccctgaagt tacttgtgtg gttgttgacg tctcacaaga ggacccagag      600

gtacaattca actggtatgt ggacggagta gaggtgcata acgccaagac taagccccgt      660

gaagagcagt tcaattctac ataccgtgta gtttcggttt taacggtctt acaccaagat      720

tggttgaacg gaaaggaata taagtgcaag gtgtccaata agggactgcc aagcagtatc      780

gaaaaaacaa tctcaaaagc aaagggacaa ccgcgtgagc cccaggttta cactctgcca      840

ccgtcgcaag aggagatgac gaagaatcag gtgtcgttaa cctgtttggt caaaggcttt      900

tatccaagcg atatcgcagt ggaatgggaa tcaaatgggc agcctgaaaa taactataag      960

acaaccccgc ctgtacttga ttctgatgga tctttttttc tttatagtcg cttaaccgtg     1020

gataaatccc gttggcagga aggtaatgtc ttctcatgct cggttatgca cgaggccctt     1080

cataaccatt acactcagaa gagcctttct ctgagtccgg ggaaaggcag cggcgagctc     1140

ggtggcagtg gtaagcctat ccctaaccct ctcctcggcc tcgattctac g              1191


<210> 1102
<211> 1041
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1102
gaagaagagg tgcagatcat ccaacccgat aaatcggtat ctgtcgcagc tggggagtcg       60

gcgattttgc attgcaccat tacatctttg ttccctgttg ggcctattca atggtttcgc      120

ggggcaggtc cggcccgcgt attgatttat aaccagcgtc aaggaccgtt cccccgtgtt      180

acaactattt cggaaacaac acgtcgtgaa aatatggatt tctcgatctc tatctctaac      240

attactcccg ccgatgcagg gacttattat tgcattaaat ttcgcaaagg aagccccgac      300

acggagttta agagtggagc gggcacggaa ttatcggtgc gcgcgaaacc cagtgctagc      360

gcggcggcgc cgccatgccc gccatgccct gcgcccgagt tcttgggtgg gccttcagtg      420

ttcctttttc ccccgaaacc aaaagatacc ctgatgattt cgcgcacccc tgaagttact      480

tgtgtggttg ttgacgtctc acaagaggac ccagaggtac aattcaactg gtatgtggac      540

ggagtagagg tgcataacgc caagactaag ccccgtgaag agcagttcaa ttctacatac      600

cgtgtagttt cggttttaac ggtcttacac caagattggt tgaacggaaa ggaatataag      660

tgcaaggtgt ccaataaggg actgccaagc agtatcgaaa aaacaatctc aaaagcaaag      720

ggacaaccgc gtgagcccca ggtttacact ctgccaccgt cgcaagagga gatgacgaag      780

aatcaggtgt cgttaacctg tttggtcaaa ggcttttatc caagcgatat cgcagtggaa      840

tgggaatcaa atgggcagcc tgaaaataac tataagacaa ccccgcctgt acttgattct      900

gatggatctt tttttcttta tagtcgctta accgtggata aatcccgttg gcaggaaggt      960

aatgtcttct catgctcggt tatgcacgag gcccttcata accattacac tcagaagagc     1020

ctttctctga gtccggggaa a                                               1041


<210> 1103
<211> 681
<212> DNA
<213> Homo sapiens

<400> 1103
gcggcggcgc cgccatgccc gccatgccct gcgcccgagt tcttgggtgg gccttcagtg       60

ttcctttttc ccccgaaacc aaaagatacc ctgatgattt cgcgcacccc tgaagttact      120

tgtgtggttg ttgacgtctc acaagaggac ccagaggtac aattcaactg gtatgtggac      180

ggagtagagg tgcataacgc caagactaag ccccgtgaag agcagttcaa ttctacatac      240

cgtgtagttt cggttttaac ggtcttacac caagattggt tgaacggaaa ggaatataag      300

tgcaaggtgt ccaataaggg actgccaagc agtatcgaaa aaacaatctc aaaagcaaag      360

ggacaaccgc gtgagcccca ggtttacact ctgccaccgt cgcaagagga gatgacgaag      420

aatcaggtgt cgttaacctg tttggtcaaa ggcttttatc caagcgatat cgcagtggaa      480

tgggaatcaa atgggcagcc tgaaaataac tataagacaa ccccgcctgt acttgattct      540

gatggatctt tttttcttta tagtcgctta accgtggata aatcccgttg gcaggaaggt      600

aatgtcttct catgctcggt tatgcacgag gcccttcata accattacac tcagaagagc      660

ctttctctga gtccggggaa a                                                681


<210> 1104
<211> 929
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1104
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcac aattgggtgg tagccaggtt aagttgcttc agtccggtgc cgcattagtg      120

aagcctggag caagtgtcaa gatgtcgtgt caggcaagcg ggtacagctt caccgattat      180

tgggtgacgt gggttaaaca atcccacgga caatcattgg aatggatcgg ggaaatctac      240

cccagtaaca ctgtgacaaa ttttaacgac aattttaaag ggaaggcaac ccttacggtg      300

gataagtcta cttccacagc gtatatggag ctgagtcgcc tgacttctga ggactctgcc      360

atctattact gtacacgtat cgggaacagt gggtatcgtg tagggtggtt catctactgg      420

gggcaaggta cccttgtgac agttttatcc gggggtggcg ggtcgggagg ggggggatca      480

ggcggtggag ggtcggatac agttctgacc cagtctccgg cattggcggt gtcaccgggg      540

gagcgtgtca cgatcagttg taaggcatcg gaatccgtgt cgagccacat gcactggtac      600

cagcagaaac cggggcagca gcctaaactg ttgatttaca aggcatcaaa tttagcctct      660

ggtgtacccg ctcgttttag tggcagtggc tcgggaacgg acttcacttt aacgattgac      720

cctgttgagg cagacgatac cgccacttac ttctgccagc agggttggaa cggcccattc      780

acttttgggg ccgggacccg tctggaactg aagcgcgcgg acgccgctgg cagcggcgag      840

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc      900

ggtcatcacc accatcacca tcaccattg                                        929


<210> 1105
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1105
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Lys Glu Leu Lys Val Thr Gln Pro Glu Lys Ser 
        35                  40                  45              


Val Ser Val Ala Ala Gly Asp Ser Thr Val Leu Asn Cys Thr Leu Thr 
    50                  55                  60                  


Ser Leu Leu Pro Val Gly Pro Ile Lys Trp Tyr Arg Gly Val Gly Gln 
65                  70                  75                  80  


Ser Arg Leu Leu Ile Tyr Ser Phe Thr Gly Glu His Phe Pro Arg Val 
                85                  90                  95      


Thr Asn Val Ser Asp Ala Thr Lys Arg Asn Asn Met Asp Phe Ser Ile 
            100                 105                 110         


Arg Ile Ser Asn Val Thr Pro Glu Asp Ala Gly Thr Tyr Tyr Cys Val 
        115                 120                 125             


Lys Phe Gln Lys Gly Pro Ser Glu Pro Asp Thr Glu Ile Gln Ser Gly 
    130                 135                 140                 


Gly Gly Thr Glu Val Tyr Val Leu Ala Lys Pro Ser Pro Pro Glu Val 
145                 150                 155                 160 


Ser Gly Pro Ala Asp Arg Gly Ile Pro Asp Gln Lys Val Asn Phe Thr 
                165                 170                 175     


Cys Lys Ser His Gly Phe Ser Pro Arg Asn Ile Thr Leu Lys Trp Phe 
            180                 185                 190         


Lys Asp Gly Gln Glu Leu His His Leu Glu Thr Thr Val Asn Pro Ser 
        195                 200                 205             


Gly Lys Asn Val Ser Tyr Asn Ile Ser Ser Thr Val Arg Val Val Leu 
    210                 215                 220                 


Asn Ser Met Asp Val His Ser Lys Val Ile Cys Glu Val Ala His Ile 
225                 230                 235                 240 


Thr Leu Asp Arg Ser Pro Leu Arg Gly Ile Ala Asn Leu Ser Asn Phe 
                245                 250                 255     


Ile Arg Val Ser Pro Thr Val Lys Val Thr Gln Gln Ser Pro Thr Ser 
            260                 265                 270         


Met Asn Gln Val Asn Leu Thr Cys Arg Ala Glu Arg Phe Tyr Pro Glu 
        275                 280                 285             


Asp Leu Gln Leu Ile Trp Leu Glu Asn Gly Asn Val Ser Arg Asn Asp 
    290                 295                 300                 


Thr Pro Lys Asn Leu Thr Lys Asn Thr Asp Gly Thr Tyr Asn Tyr Thr 
305                 310                 315                 320 


Ser Leu Phe Leu Val Asn Ser Ser Ala His Arg Glu Asp Val Val Phe 
                325                 330                 335     


Thr Cys Gln Val Lys His Asp Gln Gln Pro Ala Ile Thr Arg Asn His 
            340                 345                 350         


Thr Val Leu Gly Leu Ala His Ser Ser Asp Gln Gly Ser Met Gln Thr 
        355                 360                 365             


Phe Pro Gly Asn Asn Ala Thr His Asn Trp Asn Lys Gly Glu Leu Asn 
    370                 375                 380                 


Ser Lys Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
385                 390                 395                 400 


Thr Asp Pro Asn Ser Ser Ser Val Asp His His His His His His 
                405                 410                 415 


<210> 1106
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1106
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Gly Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Val Ser Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
    130                 135                 140                 


Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Gly Ser Gly Glu 
145                 150                 155                 160 


Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
                165                 170                 175     


Ser Thr Gly Ser Gly His His His His His His 
            180                 185         


<210> 1107
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1107
Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser 
        115                 


<210> 1108
<211> 314
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1108
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Ala Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Ile Ser Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Ser Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala 
    130                 135                 140                 


Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys 
                165                 170                 175     


Ser Val Ser Val Ala Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile 
            180                 185                 190         


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
        195                 200                 205             


Pro Ala Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
    210                 215                 220                 


Val Thr Thr Ile Ser Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser 
225                 230                 235                 240 


Ile Ser Ile Ser Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
                245                 250                 255     


Ile Lys Phe Arg Lys Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala 
            260                 265                 270         


Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Gly Ser Gly Glu Leu 
        275                 280                 285             


Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
    290                 295                 300                 


Thr Gly Ser Gly His His His His His His 
305                 310                 


<210> 1109
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1109
Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
    50                  55                  60                  


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
    130                 135                 140                 


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
145                 150                 155                 160 


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
                165                 170                 175     


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
            180                 185                 190         


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
        195                 200                 205             


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
    210                 215                 220                 


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
225                 230                 235                 240 


Val Arg Ala Lys Pro Ser 
                245     


<210> 1110
<211> 416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1110
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Gly Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Val Ser Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
    130                 135                 140                 


Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Ser Ala Ala 
145                 150                 155                 160 


Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        195                 200                 205             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys Gly Ser Gly Glu Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro 
385                 390                 395                 400 


Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His His His His His 
                405                 410                 415     


<210> 1111
<211> 385
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1111
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Ser Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys 
        35                  40                  45              


Ser Val Leu Val Ala Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile 
    50                  55                  60                  


Thr Ser Leu Phe Pro Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly 
65                  70                  75                  80  


Pro Gly Arg Val Leu Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg 
                85                  90                  95      


Val Thr Thr Val Ser Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser 
            100                 105                 110         


Ile Arg Ile Gly Asn Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys 
        115                 120                 125             


Ile Lys Phe Arg Lys Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly 
    130                 135                 140                 


Ala Gly Thr Glu Leu Ser Val Arg Ala Lys Pro Ser Ala Ser Ala Ala 
145                 150                 155                 160 


Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
                165                 170                 175     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            180                 185                 190         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
        195                 200                 205             


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    210                 215                 220                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
225                 230                 235                 240 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                245                 250                 255     


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
            260                 265                 270         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    370                 375                 380                 


Lys 
385 


<210> 1112
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1112
Glu Glu Glu Leu Gln Ile Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Thr Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro 
        115                 120                 125             


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
    130                 135                 140                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
145                 150                 155                 160 


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
                165                 170                 175     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            180                 185                 190         


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        195                 200                 205             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    210                 215                 220                 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
225                 230                 235                 240 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
                245                 250                 255     


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            260                 265                 270         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        275                 280                 285             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    290                 295                 300                 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
305                 310                 315                 320 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                325                 330                 335     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345             


<210> 1113
<211> 407
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1113
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Gln Leu Gly Gly Ser Glu Glu Glu Val 
            20                  25                  30          


Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly Glu Ser 
        35                  40                  45              


Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro Val Gly Pro Ile 
    50                  55                  60                  


Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser Glu Thr Thr Arg 
                85                  90                  95      


Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro Ala 
            100                 105                 110         


Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys Gly Ser Pro Asp 
        115                 120                 125             


Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys 
    130                 135                 140                 


Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                245                 250                 255     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Glu Leu Gly Gly Ser Gly 
    370                 375                 380                 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
385                 390                 395                 400 


Gly His His His His His His 
                405         


<210> 1114
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1114
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Gln Leu Gly Gly Ser Glu Glu Glu Val 
            20                  25                  30          


Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala Ala Gly Glu Ser 
        35                  40                  45              


Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro Val Gly Pro Ile 
    50                  55                  60                  


Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu Ile Tyr Asn Gln 
65                  70                  75                  80  


Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser Glu Thr Thr Arg 
                85                  90                  95      


Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn Ile Thr Pro Ala 
            100                 105                 110         


Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys Gly Ser Pro Asp 
        115                 120                 125             


Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser Val Arg Ala Lys 
    130                 135                 140                 


Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
                245                 250                 255     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210> 1115
<211> 347
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1115
Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
    50                  55                  60                  


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser Ala Ser Ala Ala Ala Pro Pro Cys Pro Pro 
        115                 120                 125             


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    130                 135                 140                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
145                 150                 155                 160 


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
                165                 170                 175     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            180                 185                 190         


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        195                 200                 205             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    210                 215                 220                 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235                 240 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
                245                 250                 255     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            260                 265                 270         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        275                 280                 285             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    290                 295                 300                 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
305                 310                 315                 320 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                325                 330                 335     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345         


<210> 1116
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1116
Glu Glu Glu Val Gln Ile Ile Gln Pro Asp Lys Ser Val Ser Val Ala 
1               5                   10                  15      


Ala Gly Glu Ser Ala Ile Leu His Cys Thr Ile Thr Ser Leu Phe Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Ala Arg Val Leu 
        35                  40                  45              


Ile Tyr Asn Gln Arg Gln Gly Pro Phe Pro Arg Val Thr Thr Ile Ser 
    50                  55                  60                  


Glu Thr Thr Arg Arg Glu Asn Met Asp Phe Ser Ile Ser Ile Ser Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Ile Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Thr Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu Ser 
            100                 105                 110         


Val Arg Ala Lys Pro Ser 
        115             


<210> 1117
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1117
Ala Ala Ala Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        35                  40                  45              


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 1118
<211> 307
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1118
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Gln Leu Gly Gly Ser Gln Val Lys Leu 
            20                  25                  30          


Leu Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala Ser Val Lys Met 
        35                  40                  45              


Ser Cys Gln Ala Ser Gly Tyr Ser Phe Thr Asp Tyr Trp Val Thr Trp 
    50                  55                  60                  


Val Lys Gln Ser His Gly Gln Ser Leu Glu Trp Ile Gly Glu Ile Tyr 
65                  70                  75                  80  


Pro Ser Asn Thr Val Thr Asn Phe Asn Asp Asn Phe Lys Gly Lys Ala 
                85                  90                  95      


Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
            100                 105                 110         


Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Thr Arg Ile Gly 
        115                 120                 125             


Asn Ser Gly Tyr Arg Val Gly Trp Phe Ile Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Leu Val Thr Val Leu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Asp Thr Val Leu Thr Gln Ser Pro Ala Leu Ala 
                165                 170                 175     


Val Ser Pro Gly Glu Arg Val Thr Ile Ser Cys Lys Ala Ser Glu Ser 
            180                 185                 190         


Val Ser Ser His Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro 
        195                 200                 205             


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu Ala Ser Gly Val Pro Ala 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
225                 230                 235                 240 


Pro Val Glu Ala Asp Asp Thr Ala Thr Tyr Phe Cys Gln Gln Gly Trp 
                245                 250                 255     


Asn Gly Pro Phe Thr Phe Gly Ala Gly Thr Arg Leu Glu Leu Lys Arg 
            260                 265                 270         


Ala Asp Ala Ala Gly Ser Gly Glu Leu Gly Gly Ser Gly Lys Pro Ile 
        275                 280                 285             


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His His 
    290                 295                 300                 


His His His 
305         


<210> 1119
<211> 21
<212> PRT
<213> Homo sapiens

<400> 1119
Ile Val Val Gly Val Val Cys Thr Leu Leu Val Ala Leu Leu Met Ala 
1               5                   10                  15      


Ala Leu Tyr Leu Val 
            20      


<210> 1120
<211> 110
<212> PRT
<213> Homo sapiens

<400> 1120
Arg Ile Arg Gln Lys Lys Ala Gln Gly Ser Thr Ser Ser Thr Arg Leu 
1               5                   10                  15      


His Glu Pro Glu Lys Asn Ala Arg Glu Ile Thr Gln Asp Thr Asn Asp 
            20                  25                  30          


Ile Thr Tyr Ala Asp Leu Asn Leu Pro Lys Gly Lys Lys Pro Ala Pro 
        35                  40                  45              


Gln Ala Ala Glu Pro Asn Asn His Thr Glu Tyr Ala Ser Ile Gln Thr 
    50                  55                  60                  


Ser Pro Gln Pro Ala Ser Glu Asp Thr Leu Thr Tyr Ala Asp Leu Asp 
65                  70                  75                  80  


Met Val His Leu Asn Arg Thr Pro Lys Gln Pro Ala Pro Lys Pro Glu 
                85                  90                  95      


Pro Ser Phe Ser Glu Tyr Ala Ser Val Gln Val Pro Arg Lys 
            100                 105                 110 


<210> 1121
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1121
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 1122
<211> 1452
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1122
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg ctttcgtggg      120

ccattgttac ccaaccgtcc attcaccact gtctggaacg ccaatacaca atggtgtttg      180

gagcgtcatg gagtcgatgt agatgtatcc gtgtttgatg tcgtggcgaa cccgggacag      240

acatttcgtg gaccggacat gaccatcttt tattcgtcac aacttggcac ctacccttat      300

tacactccca cgggtgagcc tgtctttggt ggacttcctc aaaatgcttc tttgattgcg      360

cacttggcgc gtactttcca agatatcctg gctgccatcc ctgccccgga tttttcggga      420

ctggctgtaa ttgattggga ggcatggcgc cctcgttggg ccttcaactg ggatacaaag      480

gacatttacc gccaacgcag ccgcgccttg gttcaggccc aacaccccga ctggccggcg      540

ccccaggtgg aagcagttgc acaggaccag ttccaaggag ccgctcgcgc ttggatggcg      600

ggtactttac agttggggcg cgctttgcgt cctcgcggct tgtggggatt ctatggtttt      660

ccagactgct ataactacga cttcttgtct cccaactaca ccggacagtg tccctctggg      720

attcgtgctc agaatgacca acttggatgg ctgtggggcc aaagtcgtgc gctgtatccg      780

agcatttata tgccagccgt tctggaagga acaggcaagt ctcagatgta cgttcaacat      840

cgtgtagcgg aagcctttcg tgtagccgtg gcggcaggtg acccaaattt gccggtctta      900

ccttacgtac agatttttta tgacactaca aatcacttcc ttccactgga tgagttagaa      960

cattcattgg gggagtcagc agctcagggc gcggctgggg tggtgttgtg ggtgagctgg     1020

gaaaacacgc gtacgaaaga gtcatgccag gctatcaagg aatacatgga tacaactctt     1080

ggtccgttta ttttgaatgt gacttctggg gcgcttttgt gttcccaggc tctttgctca     1140

ggtcatgggc gttgcgttcg ccgtacctcg catccgaaag cgcttctgct tctgaaccca     1200

gcgtcattca gcattcaact gacacctgga gggggtcctt tatcactgcg cggggcttta     1260

tctttggaag accaagctca gatggcggtc gagttcaagt gtcgctgcta cccaggttgg     1320

caggccccgt ggtgcgagcg taaaagtatg tggaagggcg agctcaattc gaagcttgaa     1380

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgcgtaccgg tcatcatcac     1440

catcaccatt ga                                                         1452


<210> 1123
<211> 1353
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1123
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg ctttcgtggg      120

ccattgttac ccaaccgtcc attcaccact gtctggaacg ccaatacaca atggtgtttg      180

gagcgtcatg gagtcgatgt agatgtatcc gtgtttgatg tcgtggcgaa cccgggacag      240

acatttcgtg gaccggacat gaccatcttt tattcgtcac aacttggcac ctacccttat      300

tacactccca cgggtgagcc tgtctttggt ggacttcctc aaaatgcttc tttgattgcg      360

cacttggcgc gtactttcca agatatcctg gctgccatcc ctgccccgga tttttcggga      420

ctggctgtaa ttgattggga ggcatggcgc cctcgttggg ccttcaactg ggatacaaag      480

gacatttacc gccaacgcag ccgcgccttg gttcaggccc aacaccccga ctggccggcg      540

ccccaggtgg aagcagttgc acaggaccag ttccaaggag ccgctcgcgc ttggatggcg      600

ggtactttac agttggggcg cgctttgcgt cctcgcggct tgtggggatt ctatggtttt      660

ccagactgct ataactacga cttcttgtct cccaactaca ccggacagtg tccctctggg      720

attcgtgctc agaatgacca acttggatgg ctgtggggcc aaagtcgtgc gctgtatccg      780

agcatttata tgccagccgt tctggaagga acaggcaagt ctcagatgta cgttcaacat      840

cgtgtagcgg aagcctttcg tgtagccgtg gcggcaggtg acccaaattt gccggtctta      900

ccttacgtac agatttttta tgacactaca aatcacttcc ttccactgga tgagttagaa      960

cattcattgg gggagtcagc agctcagggc gcggctgggg tggtgttgtg ggtgagctgg     1020

gaaaacacgc gtacgaaaga gtcatgccag gctatcaagg aatacatgga tacaactctt     1080

ggtccgttta ttttgaatgt gacttctggg gcgcttttgt gttcccaggc tctttgctca     1140

ggtcatgggc gttgcgttcg ccgtacctcg catccgaaag cgcttctgct tctgaaccca     1200

gcgtcattca gcattcaact gacacctgga gggggtcctt tatcactgcg cggggcttta     1260

tctttggaag accaagctca gatggcggtc gagttcaagt gtcgctgcta cccaggttgg     1320

caggccccgt ggtgcgagcg taaaagtatg tgg                                  1353


<210> 1124
<211> 1440
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1124
atgactagta aacaatcgac catcgcattg gcgctgcttc ctctattgtt cacaccggtg       60

acaaaggcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg ctctgttgtt      120

agcaaccgtc cctttatcac tgtgtggaac ggtgacacac attggtgttt aaccgagtac      180

ggggtcgatg tggacgtttc ggtctttgac gtcgtggcta ataaagagca atctttccaa      240

ggctctaata tgaccatctt ctatcgtgaa gagcttggca catacccata ctacacccca      300

actggcgagc cagtctttgg ggggcttccg caaaatgcct ctttggtgac tcatctggcg      360

cataccttcc aagatatcaa agcggcgatg cccgaaccag atttttccgg gttagcggta      420

atcgactggg aggcatggcg tcctcgctgg gcttttaact gggatagtaa agatatttat      480

cgccaacgtt ctatggaact tgtgcaagca gaacatcctg attggcctga gaccctggtg      540

gaggcagctg ctaaaaatca gttccaggag gcagcagaag cgtggatggc cggaacgctg      600

cagttggggc aagtgttgcg cccgcgcgga ctttggggct attatggatt ccccgactgt      660

tataacaatg acttcctttc gttaaattac accggccaat gtcccgtgtt cgttcgtgat      720

cagaatgatc agttgggatg gttgtggaac cagtcatacg ccctttatcc atccatctat      780

ttacccgccg ctttaatggg cacggagaaa tctcagatgt atgttcgcca ccgtgttcag      840

gaagcattgc gtgttgctat tgtttcccgt gacccccacg ttccggtcat gccatacgtc      900

caaatctttt acgaaatgac cgactatttg ttaccgttag aagagcttga acacagtttg      960

ggggagtcag ctgcacaagg tgtagcggga gcagtgcttt ggttgagttc agacaaaacg     1020

tctactaaag aatcatgtca agcaattaaa gcatacatgg attccacctt gggtccgttt     1080

atcgtgaacg tcacatcggc ggcattgtta tgctcagaag ccctttgctc ggggcatggc     1140

cgctgtgttc gtcatccaag ctaccccgag gctctgttga cattgaatcc tgcaagtttt     1200

tcgatcgaac tgacacatga cgggcgccca cccagtctta aaggcaccct ttcattgaaa     1260

gatcgtgctc agatggcgat gaaattccgc tgtcgttgct atcgtggttg gcgcggcaag     1320

tggtgcgata aacgtggtat gaagggcgag ctcaattcga agcttgaagg taagcctatc     1380

cctaaccctc tcctcggcct cgattctacg cgtaccggtc atcatcacca tcaccattga     1440


<210> 1125
<211> 1580
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1125
atgaaacaat cgaccatcgc attggcgctg cttcctctat tgttcacacc ggtgacaaag       60

gcacaattgg gcggtggcat gaaagagatt gctgttacca tcgacgataa aaacgtgatt      120

gcttcagtca gtgaaagctt tcacggcgtc gctttcgacg cttccctgtt ttctccgaaa      180

ggcctgtgga gttttgttga cattacgtca cccaagctgt ttaaactgct tgagggcctg      240

tctccaggtt actttcgcgt tggcgggaca ttcgcgaact ggttattctt cgacttagac      300

gagaacaaca agtggaagga ttactgggct tttaaagaca aaactcctga gacagccaca      360

attacgcgcc gttggttgtt tcgcaagcaa aacaatttaa agaaggagac gttcgatgat      420

cttgtcaagc tgactaaagg atcaaagatg cgtcttttgt ttgacctgaa tgcagaagtt      480

cgcacagggt acgaaattgg caaaaagatg accagcactt gggattcatc tgaagctgaa      540

aagctgttca agtactgtgt tagcaagggt tacggagaca atattgactg ggagcttggt      600

aacgaacccg accacacaag cgcacataac ttaactgaga agcaggtggg tgaagatttc      660

aaggcgctgc ataaagtttt ggagaagtat ccaaccttaa ataaaggatc gttggtaggg      720

cctgacgtag ggtggatggg ggtatcatac gttaaaggtc tggccgatgg tgcaggtgac      780

catgtgacag cttttacgtt acatcaatac tacttcgatg gtaacacgtc ggatgtgtca      840

acttacttgg acgctaccta ctttaaaaag ttacaacagc tgttcgataa ggtaaaagac      900

gtcttgaaaa attccccaca taaagacaaa cccctttggc ttggcgaaac tagctcgggt      960

tacaacagcg gaacgaaaga tgtgtctgac cgttatgtgt cagggttctt gacacttgat     1020

aaattgggcc ttagcgccgc taacaacgtg aaggtcgtca ttcgccagac tatctataat     1080

ggttactatg gcttgttaga caaaaacacc cttgagccta acccggacta ttggttgatg     1140

catgtacata actcgctggt agggaacact gtgttcaagg ttgacgtgtc tgatcctact     1200

aacaaggccc gtgtttacgc gcagtgtacc aaaactaata gcaaacatac acaatctcgc     1260

tactacaaag gttcccttac catttttgct ttgaatgtcg gcgacgagga tgtgacctta     1320

aagattgacc aatattctgg gaagaaaatt tattcatata ttctgactcc agaggggggt     1380

caactgacca gccaaaaagt acttttgaat ggcaaggagt tgaaactggt gagcgatcag     1440

cttccagagc tgaacgcgga tgagtccaaa acatcattta cattatctcc taagacgttc     1500

gggtttttcg tcgtgagtga cgctaatgta gaagcatgta agaaaggatc cggtcatcac     1560

caccatcacc atcaccatta                                                 1580


<210> 1126
<211> 1545
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1126
atgaaacaat cgaccatcgc attggcgctg cttcctctat tgttcacacc ggtgacaaag       60

gcacaattgg gcggtggcat gaaagagatt gctgttacca tcgacgataa aaacgtgatt      120

gcttcagtca gtgaaagctt tcacggcgtc gctttcgacg cttccctgtt ttctccgaaa      180

ggcctgtgga gttttgttga cattacgtca cccaagctgt ttaaactgct tgagggcctg      240

tctccaggtt actttcgcgt tggcgggaca ttcgcgaact ggttattctt cgacttagac      300

gagaacaaca agtggaagga ttactgggct tttaaagaca aaactcctga gacagccaca      360

attacgcgcc gttggttgtt tcgcaagcaa aacaatttaa agaaggagac gttcgatgat      420

cttgtcaagc tgactaaagg atcaaagatg cgtcttttgt ttgacctgaa tgcagaagtt      480

cgcacagggt acgaaattgg caaaaagatg accagcactt gggattcatc tgaagctgaa      540

aagctgttca agtactgtgt tagcaagggt tacggagaca atattgactg ggagcttggt      600

aacgaacccg accacacaag cgcacataac ttaactgaga agcaggtggg tgaagatttc      660

aaggcgctgc ataaagtttt ggagaagtat ccaaccttaa ataaaggatc gttggtaggg      720

cctgacgtag ggtggatggg ggtatcatac gttaaaggtc tggccgatgg tgcaggtgac      780

catgtgacag cttttacgtt acatcaatac tacttcgatg gtaacacgtc ggatgtgtca      840

acttacttgg acgctaccta ctttaaaaag ttacaacagc tgttcgataa ggtaaaagac      900

gtcttgaaaa attccccaca taaagacaaa cccctttggc ttggcgaaac tagctcgggt      960

tacaacagcg gaacgaaaga tgtgtctgac cgttatgtgt cagggttctt gacacttgat     1020

aaattgggcc ttagcgccgc taacaacgtg aaggtcgtca ttcgccagac tatctataat     1080

ggttactatg gcttgttaga caaaaacacc cttgagccta acccggacta ttggttgatg     1140

catgtacata actcgctggt agggaacact gtgttcaagg ttgacgtgtc tgatcctact     1200

aacaaggccc gtgtttacgc gcagtgtacc aaaactaata gcaaacatac acaatctcgc     1260

tactacaaag gttcccttac catttttgct ttgaatgtcg gcgacgagga tgtgacctta     1320

aagattgacc aatattctgg gaagaaaatt tattcatata ttctgactcc agaggggggt     1380

caactgacca gccaaaaagt acttttgaat ggcaaggagt tgaaactggt gagcgatcag     1440

cttccagagc tgaacgcgga tgagtccaaa acatcattta cattatctcc taagacgttc     1500

gggtttttcg tcgtgagtga cgctaatgta gaagcatgta agaaa                     1545


<210> 1127
<211> 483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1127
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
        35                  40                  45              


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
    50                  55                  60                  


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
65                  70                  75                  80  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
                85                  90                  95      


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
            100                 105                 110         


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
        115                 120                 125             


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
    130                 135                 140                 


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
145                 150                 155                 160 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
                165                 170                 175     


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
            180                 185                 190         


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
        195                 200                 205             


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
    210                 215                 220                 


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
225                 230                 235                 240 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
                245                 250                 255     


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
            260                 265                 270         


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
        275                 280                 285             


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
    290                 295                 300                 


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
305                 310                 315                 320 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
                325                 330                 335     


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
            340                 345                 350         


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
        355                 360                 365             


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
    370                 375                 380                 


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
385                 390                 395                 400 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
                405                 410                 415     


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
            420                 425                 430         


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
        435                 440                 445             


Ser Met Trp Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile 
    450                 455                 460                 


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
465                 470                 475                 480 


His His His 
            


<210> 1128
<211> 414
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1128
Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe Thr Thr Val Trp Asn 
1               5                   10                  15      


Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly Val Asp Val Asp Val 
            20                  25                  30          


Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln Thr Phe Arg Gly Pro 
        35                  40                  45              


Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly Thr Tyr Pro Tyr Tyr 
    50                  55                  60                  


Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu Pro Gln Asn Ala Ser 
65                  70                  75                  80  


Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp Ile Leu Ala Ala Ile 
                85                  90                  95      


Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile Asp Trp Glu Ala Trp 
            100                 105                 110         


Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys Asp Ile Tyr Arg Gln 
        115                 120                 125             


Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro Asp Trp Pro Ala Pro 
    130                 135                 140                 


Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln Gly Ala Ala Arg Ala 
145                 150                 155                 160 


Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala Leu Arg Pro Arg Gly 
                165                 170                 175     


Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr Asn Tyr Asp Phe Leu 
            180                 185                 190         


Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly Ile Arg Ala Gln Asn 
        195                 200                 205             


Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg Ala Leu Tyr Pro Ser 
    210                 215                 220                 


Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly Lys Ser Gln Met Tyr 
225                 230                 235                 240 


Val Gln His Arg Val Ala Glu Ala Phe Arg Val Ala Val Ala Ala Gly 
                245                 250                 255     


Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln Ile Phe Tyr Asp Thr 
            260                 265                 270         


Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu His Ser Leu Gly Glu 
        275                 280                 285             


Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu Trp Val Ser Trp Glu 
    290                 295                 300                 


Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile Lys Glu Tyr Met Asp 
305                 310                 315                 320 


Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr Ser Gly Ala Leu Leu 
                325                 330                 335     


Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg Cys Val Arg Arg Thr 
            340                 345                 350         


Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro Ala Ser Phe Ser Ile 
        355                 360                 365             


Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu Arg Gly Ala Leu Ser 
    370                 375                 380                 


Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe Lys Cys Arg Cys Tyr 
385                 390                 395                 400 


Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys Ser Met Trp 
                405                 410                 


<210> 1129
<211> 451
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1129
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Phe Arg Gly Pro Leu Leu Pro Asn Arg Pro Phe 
        35                  40                  45              


Thr Thr Val Trp Asn Ala Asn Thr Gln Trp Cys Leu Glu Arg His Gly 
    50                  55                  60                  


Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Pro Gly Gln 
65                  70                  75                  80  


Thr Phe Arg Gly Pro Asp Met Thr Ile Phe Tyr Ser Ser Gln Leu Gly 
                85                  90                  95      


Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly Leu 
            100                 105                 110         


Pro Gln Asn Ala Ser Leu Ile Ala His Leu Ala Arg Thr Phe Gln Asp 
        115                 120                 125             


Ile Leu Ala Ala Ile Pro Ala Pro Asp Phe Ser Gly Leu Ala Val Ile 
    130                 135                 140                 


Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Thr Lys 
145                 150                 155                 160 


Asp Ile Tyr Arg Gln Arg Ser Arg Ala Leu Val Gln Ala Gln His Pro 
                165                 170                 175     


Asp Trp Pro Ala Pro Gln Val Glu Ala Val Ala Gln Asp Gln Phe Gln 
            180                 185                 190         


Gly Ala Ala Arg Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Arg Ala 
        195                 200                 205             


Leu Arg Pro Arg Gly Leu Trp Gly Phe Tyr Gly Phe Pro Asp Cys Tyr 
    210                 215                 220                 


Asn Tyr Asp Phe Leu Ser Pro Asn Tyr Thr Gly Gln Cys Pro Ser Gly 
225                 230                 235                 240 


Ile Arg Ala Gln Asn Asp Gln Leu Gly Trp Leu Trp Gly Gln Ser Arg 
                245                 250                 255     


Ala Leu Tyr Pro Ser Ile Tyr Met Pro Ala Val Leu Glu Gly Thr Gly 
            260                 265                 270         


Lys Ser Gln Met Tyr Val Gln His Arg Val Ala Glu Ala Phe Arg Val 
        275                 280                 285             


Ala Val Ala Ala Gly Asp Pro Asn Leu Pro Val Leu Pro Tyr Val Gln 
    290                 295                 300                 


Ile Phe Tyr Asp Thr Thr Asn His Phe Leu Pro Leu Asp Glu Leu Glu 
305                 310                 315                 320 


His Ser Leu Gly Glu Ser Ala Ala Gln Gly Ala Ala Gly Val Val Leu 
                325                 330                 335     


Trp Val Ser Trp Glu Asn Thr Arg Thr Lys Glu Ser Cys Gln Ala Ile 
            340                 345                 350         


Lys Glu Tyr Met Asp Thr Thr Leu Gly Pro Phe Ile Leu Asn Val Thr 
        355                 360                 365             


Ser Gly Ala Leu Leu Cys Ser Gln Ala Leu Cys Ser Gly His Gly Arg 
    370                 375                 380                 


Cys Val Arg Arg Thr Ser His Pro Lys Ala Leu Leu Leu Leu Asn Pro 
385                 390                 395                 400 


Ala Ser Phe Ser Ile Gln Leu Thr Pro Gly Gly Gly Pro Leu Ser Leu 
                405                 410                 415     


Arg Gly Ala Leu Ser Leu Glu Asp Gln Ala Gln Met Ala Val Glu Phe 
            420                 425                 430         


Lys Cys Arg Cys Tyr Pro Gly Trp Gln Ala Pro Trp Cys Glu Arg Lys 
        435                 440                 445             


Ser Met Trp 
    450     


<210> 1130
<211> 499
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1130
Met Thr Ser Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu 
1               5                   10                  15      


Phe Thr Pro Val Thr Lys Ala Lys Gln Ser Thr Ile Ala Leu Ala Leu 
            20                  25                  30          


Leu Pro Leu Leu Phe Thr Pro Val Thr Lys Ala Val Asp Tyr Lys Asp 
        35                  40                  45              


Asp Asp Asp Lys Asp Leu Gly Gly Gly Ser Val Val Ser Asn Arg Pro 
    50                  55                  60                  


Phe Ile Thr Val Trp Asn Gly Asp Thr His Trp Cys Leu Thr Glu Tyr 
65                  70                  75                  80  


Gly Val Asp Val Asp Val Ser Val Phe Asp Val Val Ala Asn Lys Glu 
                85                  90                  95      


Gln Ser Phe Gln Gly Ser Asn Met Thr Ile Phe Tyr Arg Glu Glu Leu 
            100                 105                 110         


Gly Thr Tyr Pro Tyr Tyr Thr Pro Thr Gly Glu Pro Val Phe Gly Gly 
        115                 120                 125             


Leu Pro Gln Asn Ala Ser Leu Val Thr His Leu Ala His Thr Phe Gln 
    130                 135                 140                 


Asp Ile Lys Ala Ala Met Pro Glu Pro Asp Phe Ser Gly Leu Ala Val 
145                 150                 155                 160 


Ile Asp Trp Glu Ala Trp Arg Pro Arg Trp Ala Phe Asn Trp Asp Ser 
                165                 170                 175     


Lys Asp Ile Tyr Arg Gln Arg Ser Met Glu Leu Val Gln Ala Glu His 
            180                 185                 190         


Pro Asp Trp Pro Glu Thr Leu Val Glu Ala Ala Ala Lys Asn Gln Phe 
        195                 200                 205             


Gln Glu Ala Ala Glu Ala Trp Met Ala Gly Thr Leu Gln Leu Gly Gln 
    210                 215                 220                 


Val Leu Arg Pro Arg Gly Leu Trp Gly Tyr Tyr Gly Phe Pro Asp Cys 
225                 230                 235                 240 


Tyr Asn Asn Asp Phe Leu Ser Leu Asn Tyr Thr Gly Gln Cys Pro Val 
                245                 250                 255     


Phe Val Arg Asp Gln Asn Asp Gln Leu Gly Trp Leu Trp Asn Gln Ser 
            260                 265                 270         


Tyr Ala Leu Tyr Pro Ser Ile Tyr Leu Pro Ala Ala Leu Met Gly Thr 
        275                 280                 285             


Glu Lys Ser Gln Met Tyr Val Arg His Arg Val Gln Glu Ala Leu Arg 
    290                 295                 300                 


Val Ala Ile Val Ser Arg Asp Pro His Val Pro Val Met Pro Tyr Val 
305                 310                 315                 320 


Gln Ile Phe Tyr Glu Met Thr Asp Tyr Leu Leu Pro Leu Glu Glu Leu 
                325                 330                 335     


Glu His Ser Leu Gly Glu Ser Ala Ala Gln Gly Val Ala Gly Ala Val 
            340                 345                 350         


Leu Trp Leu Ser Ser Asp Lys Thr Ser Thr Lys Glu Ser Cys Gln Ala 
        355                 360                 365             


Ile Lys Ala Tyr Met Asp Ser Thr Leu Gly Pro Phe Ile Val Asn Val 
    370                 375                 380                 


Thr Ser Ala Ala Leu Leu Cys Ser Glu Ala Leu Cys Ser Gly His Gly 
385                 390                 395                 400 


Arg Cys Val Arg His Pro Ser Tyr Pro Glu Ala Leu Leu Thr Leu Asn 
                405                 410                 415     


Pro Ala Ser Phe Ser Ile Glu Leu Thr His Asp Gly Arg Pro Pro Ser 
            420                 425                 430         


Leu Lys Gly Thr Leu Ser Leu Lys Asp Arg Ala Gln Met Ala Met Lys 
        435                 440                 445             


Phe Arg Cys Arg Cys Tyr Arg Gly Trp Arg Gly Lys Trp Cys Asp Lys 
    450                 455                 460                 


Arg Gly Met Lys Gly Glu Leu Asn Ser Lys Leu Glu Gly Lys Pro Ile 
465                 470                 475                 480 


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Arg Thr Gly His His His 
                485                 490                 495     


His His His 
            


<210> 1131
<211> 489
<212> PRT
<213> Hirudo nipponia

<400> 1131
Met Lys Glu Ile Ala Val Thr Ile Asp Asp Lys Asn Val Ile Ala Ser 
1               5                   10                  15      


Val Ser Glu Ser Phe His Gly Val Ala Phe Asp Ala Ser Leu Phe Ser 
            20                  25                  30          


Pro Lys Gly Leu Trp Ser Phe Val Asp Ile Thr Ser Pro Lys Leu Phe 
        35                  40                  45              


Lys Leu Leu Glu Gly Leu Ser Pro Gly Tyr Phe Arg Val Gly Gly Thr 
    50                  55                  60                  


Phe Ala Asn Trp Leu Phe Phe Asp Leu Asp Glu Asn Asn Lys Trp Lys 
65                  70                  75                  80  


Asp Tyr Trp Ala Phe Lys Asp Lys Thr Pro Glu Thr Ala Thr Ile Thr 
                85                  90                  95      


Arg Arg Trp Leu Phe Arg Lys Gln Asn Asn Leu Lys Lys Glu Thr Phe 
            100                 105                 110         


Asp Asp Leu Val Lys Leu Thr Lys Gly Ser Lys Met Arg Leu Leu Phe 
        115                 120                 125             


Asp Leu Asn Ala Glu Val Arg Thr Gly Tyr Glu Ile Gly Lys Lys Met 
    130                 135                 140                 


Thr Ser Thr Trp Asp Ser Ser Glu Ala Glu Lys Leu Phe Lys Tyr Cys 
145                 150                 155                 160 


Val Ser Lys Gly Tyr Gly Asp Asn Ile Asp Trp Glu Leu Gly Asn Glu 
                165                 170                 175     


Pro Asp His Thr Ser Ala His Asn Leu Thr Glu Lys Gln Val Gly Glu 
            180                 185                 190         


Asp Phe Lys Ala Leu His Lys Val Leu Glu Lys Tyr Pro Thr Leu Asn 
        195                 200                 205             


Lys Gly Ser Leu Val Gly Pro Asp Val Gly Trp Met Gly Val Ser Tyr 
    210                 215                 220                 


Val Lys Gly Leu Ala Asp Gly Ala Gly Asp His Val Thr Ala Phe Thr 
225                 230                 235                 240 


Leu His Gln Tyr Tyr Phe Asp Gly Asn Thr Ser Asp Val Ser Thr Tyr 
                245                 250                 255     


Leu Asp Ala Thr Tyr Phe Lys Lys Leu Gln Gln Leu Phe Asp Lys Val 
            260                 265                 270         


Lys Asp Val Leu Lys Asn Ser Pro His Lys Asp Lys Pro Leu Trp Leu 
        275                 280                 285             


Gly Glu Thr Ser Ser Gly Tyr Asn Ser Gly Thr Lys Asp Val Ser Asp 
    290                 295                 300                 


Arg Tyr Val Ser Gly Phe Leu Thr Leu Asp Lys Leu Gly Leu Ser Ala 
305                 310                 315                 320 


Ala Asn Asn Val Lys Val Val Ile Arg Gln Thr Ile Tyr Asn Gly Tyr 
                325                 330                 335     


Tyr Gly Leu Leu Asp Lys Asn Thr Leu Glu Pro Asn Pro Asp Tyr Trp 
            340                 345                 350         


Leu Met His Val His Asn Ser Leu Val Gly Asn Thr Val Phe Lys Val 
        355                 360                 365             


Asp Val Ser Asp Pro Thr Asn Lys Ala Arg Val Tyr Ala Gln Cys Thr 
    370                 375                 380                 


Lys Thr Asn Ser Lys His Thr Gln Ser Arg Tyr Tyr Lys Gly Ser Leu 
385                 390                 395                 400 


Thr Ile Phe Ala Leu Asn Val Gly Asp Glu Asp Val Thr Leu Lys Ile 
                405                 410                 415     


Asp Gln Tyr Ser Gly Lys Lys Ile Tyr Ser Tyr Ile Leu Thr Pro Glu 
            420                 425                 430         


Gly Gly Gln Leu Thr Ser Gln Lys Val Leu Leu Asn Gly Lys Glu Leu 
        435                 440                 445             


Lys Leu Val Ser Asp Gln Leu Pro Glu Leu Asn Ala Asp Glu Ser Lys 
    450                 455                 460                 


Thr Ser Phe Thr Leu Ser Pro Lys Thr Phe Gly Phe Phe Val Val Ser 
465                 470                 475                 480 


Asp Ala Asn Val Glu Ala Cys Lys Lys 
                485                 


<210> 1132
<211> 78
<212> PRT
<213> Homo sapiens

<400> 1132
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
65                  70                  75              


<210> 1133
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1133
Met Phe Lys Ser Thr Leu Ala Ala Met Ala Ala Val Phe Ala Leu Ser 
1               5                   10                  15      


Ala Leu Ser Pro Ala Ala Met Ala Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Ile Glu Gly Arg Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
        35                  40                  45              


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
    50                  55                  60                  


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
65                  70                  75                  80  


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
                85                  90                  95      


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
            100                 105                 110         


Pro Ser Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
    130                 135                 140                 


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
145                 150                 155                 160 


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
                165                 170                 175     


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
            180                 185                 190         


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu 
        195                 200                 205             


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
    210                 215                 220                 


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
225                 230                 235                 240 


Val Gln Met Phe Ile Asn Thr Ser 
                245             


<210> 1134
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1134
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Ser Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                85                  90                  95      


Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp 
            100                 105                 110         


Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp 
        115                 120                 125             


Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu 
    130                 135                 140                 


Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr 
145                 150                 155                 160 


Val Glu Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly 
                165                 170                 175     


Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys 
            180                 185                 190         


Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe 
        195                 200                 205             


Ile Asn Thr Ser 
    210         


<210> 1135
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1135
Met Phe Lys Ser Thr Leu Ala Ala Met Ala Ala Val Phe Ala Leu Ser 
1               5                   10                  15      


Ala Leu Ser Pro Ala Ala Met Ala 
            20                  


<210> 1136
<211> 114
<212> PRT
<213> Homo sapiens

<400> 1136
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asp Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 1137
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1137
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Leu Gln 
            20  


<210> 1138
<211> 234
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1138
atcacctgcc cgcctccaat gtctgttgag cacgcagata tttgggtaaa atcttactct       60

ttatattccc gtgaacgcta tatctgtaat agtggcttca agcgcaaggc aggcacatcc      120

tcactgacgg agtgtgtttt aaacaaagca acaaacgtcg ctcactggac gacgcccagc      180

ctgaagtgca tccgcgaccc ggcattggtc catcaacgtc cagcccctcc ctca            234


<210> 1139
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1139
atgtttaagt ctacacttgc agccatggcc gcagtcttcg cactgtcagc cttgagtcct       60

gctgcaatgg cagattataa agacgatgac gataagatcg aaggacgtat cacctgcccg      120

cctccaatgt ctgttgagca cgcagatatt tgggtaaaat cttactcttt atattcccgt      180

gaacgctata tctgtaatag tggcttcaag cgcaaggcag gcacatcctc actgacggag      240

tgtgttttaa acaaagcaac aaacgtcgct cactggacga cgcccagcct gaagtgcatc      300

cgcgacccgg cattggtcca tcaacgtcca gcccctccct catccggagg gagcggcggc      360

gggggtagtg gaggcgggtc aggcggcggg ggctcacttc agaactgggt gaatgtcatc      420

tcggacttaa agaagattga agacttgatt cagagcatgc atatcgacgc gactttatac      480

accgagtctg acgtacaccc aagttgcaag gtcaccgcca tgaagtgctt cttgcttgag      540

ttacaagtca tcagtttgga atctggagac gctagtattc acgatacggt ggaaaacctg      600

atcatccttg caaatgactc tctttcatcc aatggtaatg ttactgagtc ggggtgcaaa      660

gaatgtgaag aacttgagga gaagaacatt aaggaatttc ttcagtcatt cgtgcatatc      720

gtacagatgt tcatcaacac ctcttaa                                          747


<210> 1140
<211> 639
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1140
atcacctgcc cgcctccaat gtctgttgag cacgcagata tttgggtaaa atcttactct       60

ttatattccc gtgaacgcta tatctgtaat agtggcttca agcgcaaggc aggcacatcc      120

tcactgacgg agtgtgtttt aaacaaagca acaaacgtcg ctcactggac gacgcccagc      180

ctgaagtgca tccgcgaccc ggcattggtc catcaacgtc cagcccctcc ctcatccgga      240

gggagcggcg gcgggggtag tggaggcggg tcaggcggcg ggggctcact tcagaactgg      300

gtgaatgtca tctcggactt aaagaagatt gaagacttga ttcagagcat gcatatcgac      360

gcgactttat acaccgagtc tgacgtacac ccaagttgca aggtcaccgc catgaagtgc      420

ttcttgcttg agttacaagt catcagtttg gaatctggag acgctagtat tcacgatacg      480

gtggaaaacc tgatcatcct tgcaaatgac tctctttcat ccaatggtaa tgttactgag      540

tcggggtgca aagaatgtga agaacttgag gagaagaaca ttaaggaatt tcttcagtca      600

ttcgtgcata tcgtacagat gttcatcaac acctcttaa                             639


<210> 1141
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1141
atgtttaagt ctacacttgc agccatggcc gcagtcttcg cactgtcagc cttgagtcct       60

gctgcaatgg ca                                                           72


<210> 1142
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1142
atgaagcagg cgcttcgcgt tgcgtttggg ttccttatcc tgtgggcatc cgtacttcac       60

gcc                                                                     63


<210> 1143
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1143
atgcgcgtac tgttattcct tctgttgtct ctttttatgt tgcccgcttt cagt             54


<210> 1144
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1144
atgaagaaga ctgccatcgc tattgccgtc gcccttgcgg gtttcgcaac cgtggcgcaa       60

gca                                                                     63


<210> 1145
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1145
atgaaatatc tgcttccaac ggctgctgct ggcctgttgc ttcttgccgc ccagcctgcg       60

atggct                                                                  66


<210> 1146
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1146
atgaaaaaga tttggctggc tcttgccggt ttagtcctgg cattcagcgc aagcgcggtc       60

gactataagg atgacgacga caagcaattg ggcggtggca tctgggagct taagaaggac      120

gtgtatgtag tggagttaga ctggtatcca gatgcccccg gagagatggt ggtcttaaca      180

tgtgacactc cagaggagga cgggattacc tggacacttg accagtcaag cgaggtattg      240

ggttctggaa agacgcttac tattcaagtc aaagaatttg gggatgccgg gcagtataca      300

tgtcacaagg gcggcgaagt tctgtcgcac tccttacttt tgttacacaa aaaagaagac      360

ggcatttggt ccacagacat ccttaaggac caaaaggagc cgaagaataa gacgtttctg      420

cgctgtgaag cgaagaacta tagtggtcgc tttacttgct ggtggttgac gaccatttcc      480

actgatttaa ccttttcggt aaagagttct cgcgggagtt ccgacccaca gggcgtgact      540

tgtggcgcag ccacactttc ggcggaacgc gttcgtgggg acaataagga atacgaatat      600

tcggtcgagt gtcaggaaga ttcagcttgc cctgccgctg aggagtcact tccgattgaa      660

gtgatggttg acgccgtgca caaattaaag tatgaaaatt acacgtcatc tttctttatc      720

cgtgacatta ttaagcccga cccgccaaag aatctgcagc ttaaacccct gaagaacagc      780

cgccaggtgg aagtaagctg ggaatatcct gacacctggt ccactccgca ttcgtatttc      840

tcgttgacgt tttgtgttca ggtgcaggga aagagcaagc gcgaaaagaa ggatcgcgtc      900

tttacagaca aaacgtccgc gacggttatt tgtcgtaaga atgctagtat ctctgttcgc      960

gctcaggacc gttattactc atctagttgg tcggagtggg cctcggttcc ctgctctggg     1020

ggtggaggat cgggtggagg tggctcggga ggtggcggct cccgtaattt accggtggct     1080

actcctgacc cagggatgtt cccgtgcttg caccatagcc aaaacttact tcgcgctgtc     1140

agcaacatgc ttcagaaagc acgtcaaacg cttgagtttt acccgtgtac tagcgaagag     1200

atcgatcacg aggacattac caaagacaaa acctccaccg tcgaggcctg ccttccactt     1260

gaactgacga aaaatgagtc atgcttaaat tctcgtgaaa cctccttcat tactaacgga     1320

tcgtgcctgg cctcgcgcaa gacttcgttc atgatggcat tatgcttgtc gtctatttat     1380

gaagacctta aaatgtatca agtggagttc aagacgatga atgcaaaact tcttatggac     1440

ccgaagcgtc aaatcttctt agaccaaaac atgttggccg tgatcgatga actgatgcaa     1500

gccttgaatt ttaattcgga aactgtaccg caaaaatctt ctcttgaaga accggatttc     1560

tataagacca aaattaaact ttgtatttta cttcacgctt tccgcatccg tgcagtaact     1620

atcgaccgcg taatgagtta ccttaacgcc tcgggtggcg agctcggtgg cagtggtaag     1680

cctatcccta accctctcct cggcctcgat tctacgggat ccggtcatca ccaccatcac     1740

catcaccat                                                             1749


<210> 1147
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1147
atgaaacaga gcacaatcgc tttagccttg ctgcctcttc ttttcacgcc tgtcacgaag       60

gcagtcgact ataaggatga cgacgacaag caattgggcg gtggcatctg ggagcttaag      120

aaggacgtgt atgtagtgga gttagactgg tatccagatg cccccggaga gatggtggtc      180

ttaacatgtg acactccaga ggaggacggg attacctgga cacttgacca gtcaagcgag      240

gtattgggtt ctggaaagac gcttactatt caagtcaaag aatttgggga tgccgggcag      300

tatacatgtc acaagggcgg cgaagttctg tcgcactcct tacttttgtt acacaaaaaa      360

gaagacggca tttggtccac agacatcctt aaggaccaaa aggagccgaa gaataagacg      420

tttctgcgct gtgaagcgaa gaactatagt ggtcgcttta cttgctggtg gttgacgacc      480

atttccactg atttaacctt ttcggtaaag agttctcgcg ggagttccga cccacagggc      540

gtgacttgtg gcgcagccac actttcggcg gaacgcgttc gtggggacaa taaggaatac      600

gaatattcgg tcgagtgtca ggaagattca gcttgccctg ccgctgagga gtcacttccg      660

attgaagtga tggttgacgc cgtgcacaaa ttaaagtatg aaaattacac gtcatctttc      720

tttatccgtg acattattaa gcccgacccg ccaaagaatc tgcagcttaa acccctgaag      780

aacagccgcc aggtggaagt aagctgggaa tatcctgaca cctggtccac tccgcattcg      840

tatttctcgt tgacgttttg tgttcaggtg cagggaaaga gcaagcgcga aaagaaggat      900

cgcgtcttta cagacaaaac gtccgcgacg gttatttgtc gtaagaatgc tagtatctct      960

gttcgcgctc aggaccgtta ttactcatct agttggtcgg agtgggcctc ggttccctgc     1020

tctgggggtg gaggatcggg tggaggtggc tcgggaggtg gcggctcccg taatttaccg     1080

gtggctactc ctgacccagg gatgttcccg tgcttgcacc atagccaaaa cttacttcgc     1140

gctgtcagca acatgcttca gaaagcacgt caaacgcttg agttttaccc gtgtactagc     1200

gaagagatcg atcacgagga cattaccaaa gacaaaacct ccaccgtcga ggcctgcctt     1260

ccacttgaac tgacgaaaaa tgagtcatgc ttaaattctc gtgaaacctc cttcattact     1320

aacggatcgt gcctggcctc gcgcaagact tcgttcatga tggcattatg cttgtcgtct     1380

atttatgaag accttaaaat gtatcaagtg gagttcaaga cgatgaatgc aaaacttctt     1440

atggacccga agcgtcaaat cttcttagac caaaacatgt tggccgtgat cgatgaactg     1500

atgcaagcct tgaattttaa ttcggaaact gtaccgcaaa aatcttctct tgaagaaccg     1560

gatttctata agaccaaaat taaactttgt attttacttc acgctttccg catccgtgca     1620

gtaactatcg accgcgtaat gagttacctt aacgcctcgg gtggcgagct cggtggcagt     1680

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgggatccgg tcatcaccac     1740

catcaccatc accat                                                      1755


<210> 1148
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1148
atgaagcagg ctctgcgcgt ggcatttggg ttcctgatct tatgggcgtc cgtcttacac       60

gcagtcgact ataaggatga cgacgacaag caattgggcg gtggcatctg ggagcttaag      120

aaggacgtgt atgtagtgga gttagactgg tatccagatg cccccggaga gatggtggtc      180

ttaacatgtg acactccaga ggaggacggg attacctgga cacttgacca gtcaagcgag      240

gtattgggtt ctggaaagac gcttactatt caagtcaaag aatttgggga tgccgggcag      300

tatacatgtc acaagggcgg cgaagttctg tcgcactcct tacttttgtt acacaaaaaa      360

gaagacggca tttggtccac agacatcctt aaggaccaaa aggagccgaa gaataagacg      420

tttctgcgct gtgaagcgaa gaactatagt ggtcgcttta cttgctggtg gttgacgacc      480

atttccactg atttaacctt ttcggtaaag agttctcgcg ggagttccga cccacagggc      540

gtgacttgtg gcgcagccac actttcggcg gaacgcgttc gtggggacaa taaggaatac      600

gaatattcgg tcgagtgtca ggaagattca gcttgccctg ccgctgagga gtcacttccg      660

attgaagtga tggttgacgc cgtgcacaaa ttaaagtatg aaaattacac gtcatctttc      720

tttatccgtg acattattaa gcccgacccg ccaaagaatc tgcagcttaa acccctgaag      780

aacagccgcc aggtggaagt aagctgggaa tatcctgaca cctggtccac tccgcattcg      840

tatttctcgt tgacgttttg tgttcaggtg cagggaaaga gcaagcgcga aaagaaggat      900

cgcgtcttta cagacaaaac gtccgcgacg gttatttgtc gtaagaatgc tagtatctct      960

gttcgcgctc aggaccgtta ttactcatct agttggtcgg agtgggcctc ggttccctgc     1020

tctgggggtg gaggatcggg tggaggtggc tcgggaggtg gcggctcccg taatttaccg     1080

gtggctactc ctgacccagg gatgttcccg tgcttgcacc atagccaaaa cttacttcgc     1140

gctgtcagca acatgcttca gaaagcacgt caaacgcttg agttttaccc gtgtactagc     1200

gaagagatcg atcacgagga cattaccaaa gacaaaacct ccaccgtcga ggcctgcctt     1260

ccacttgaac tgacgaaaaa tgagtcatgc ttaaattctc gtgaaacctc cttcattact     1320

aacggatcgt gcctggcctc gcgcaagact tcgttcatga tggcattatg cttgtcgtct     1380

atttatgaag accttaaaat gtatcaagtg gagttcaaga cgatgaatgc aaaacttctt     1440

atggacccga agcgtcaaat cttcttagac caaaacatgt tggccgtgat cgatgaactg     1500

atgcaagcct tgaattttaa ttcggaaact gtaccgcaaa aatcttctct tgaagaaccg     1560

gatttctata agaccaaaat taaactttgt attttacttc acgctttccg catccgtgca     1620

gtaactatcg accgcgtaat gagttacctt aacgcctcgg gtggcgagct cggtggcagt     1680

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgggatccgg tcatcaccac     1740

catcaccatc accat                                                      1755


<210> 1149
<211> 1770
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1149
atgaaaatca agacgggggc acgcattctt gccttgagcg ccttgacaac gatgatgttc       60

agtgcaagtg cattagcggt cgactataag gatgacgacg acaagcaatt gggcggtggc      120

atctgggagc ttaagaagga cgtgtatgta gtggagttag actggtatcc agatgccccc      180

ggagagatgg tggtcttaac atgtgacact ccagaggagg acgggattac ctggacactt      240

gaccagtcaa gcgaggtatt gggttctgga aagacgctta ctattcaagt caaagaattt      300

ggggatgccg ggcagtatac atgtcacaag ggcggcgaag ttctgtcgca ctccttactt      360

ttgttacaca aaaaagaaga cggcatttgg tccacagaca tccttaagga ccaaaaggag      420

ccgaagaata agacgtttct gcgctgtgaa gcgaagaact atagtggtcg ctttacttgc      480

tggtggttga cgaccatttc cactgattta accttttcgg taaagagttc tcgcgggagt      540

tccgacccac agggcgtgac ttgtggcgca gccacacttt cggcggaacg cgttcgtggg      600

gacaataagg aatacgaata ttcggtcgag tgtcaggaag attcagcttg ccctgccgct      660

gaggagtcac ttccgattga agtgatggtt gacgccgtgc acaaattaaa gtatgaaaat      720

tacacgtcat ctttctttat ccgtgacatt attaagcccg acccgccaaa gaatctgcag      780

cttaaacccc tgaagaacag ccgccaggtg gaagtaagct gggaatatcc tgacacctgg      840

tccactccgc attcgtattt ctcgttgacg ttttgtgttc aggtgcaggg aaagagcaag      900

cgcgaaaaga aggatcgcgt ctttacagac aaaacgtccg cgacggttat ttgtcgtaag      960

aatgctagta tctctgttcg cgctcaggac cgttattact catctagttg gtcggagtgg     1020

gcctcggttc cctgctctgg gggtggagga tcgggtggag gtggctcggg aggtggcggc     1080

tcccgtaatt taccggtggc tactcctgac ccagggatgt tcccgtgctt gcaccatagc     1140

caaaacttac ttcgcgctgt cagcaacatg cttcagaaag cacgtcaaac gcttgagttt     1200

tacccgtgta ctagcgaaga gatcgatcac gaggacatta ccaaagacaa aacctccacc     1260

gtcgaggcct gccttccact tgaactgacg aaaaatgagt catgcttaaa ttctcgtgaa     1320

acctccttca ttactaacgg atcgtgcctg gcctcgcgca agacttcgtt catgatggca     1380

ttatgcttgt cgtctattta tgaagacctt aaaatgtatc aagtggagtt caagacgatg     1440

aatgcaaaac ttcttatgga cccgaagcgt caaatcttct tagaccaaaa catgttggcc     1500

gtgatcgatg aactgatgca agccttgaat tttaattcgg aaactgtacc gcaaaaatct     1560

tctcttgaag aaccggattt ctataagacc aaaattaaac tttgtatttt acttcacgct     1620

ttccgcatcc gtgcagtaac tatcgaccgc gtaatgagtt accttaacgc ctcgggtggc     1680

gagctcggtg gcagtggtaa gcctatccct aaccctctcc tcggcctcga ttctacggga     1740

tccggtcatc accaccatca ccatcaccat                                      1770


<210> 1150
<211> 1761
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1150
atgaataaga aagtcttgac attgtcggcg gtcatggcct cgatgttgtt cggggcagca       60

gcccacgcag tcgactataa ggatgacgac gacaagcaat tgggcggtgg catctgggag      120

cttaagaagg acgtgtatgt agtggagtta gactggtatc cagatgcccc cggagagatg      180

gtggtcttaa catgtgacac tccagaggag gacgggatta cctggacact tgaccagtca      240

agcgaggtat tgggttctgg aaagacgctt actattcaag tcaaagaatt tggggatgcc      300

gggcagtata catgtcacaa gggcggcgaa gttctgtcgc actccttact tttgttacac      360

aaaaaagaag acggcatttg gtccacagac atccttaagg accaaaagga gccgaagaat      420

aagacgtttc tgcgctgtga agcgaagaac tatagtggtc gctttacttg ctggtggttg      480

acgaccattt ccactgattt aaccttttcg gtaaagagtt ctcgcgggag ttccgaccca      540

cagggcgtga cttgtggcgc agccacactt tcggcggaac gcgttcgtgg ggacaataag      600

gaatacgaat attcggtcga gtgtcaggaa gattcagctt gccctgccgc tgaggagtca      660

cttccgattg aagtgatggt tgacgccgtg cacaaattaa agtatgaaaa ttacacgtca      720

tctttcttta tccgtgacat tattaagccc gacccgccaa agaatctgca gcttaaaccc      780

ctgaagaaca gccgccaggt ggaagtaagc tgggaatatc ctgacacctg gtccactccg      840

cattcgtatt tctcgttgac gttttgtgtt caggtgcagg gaaagagcaa gcgcgaaaag      900

aaggatcgcg tctttacaga caaaacgtcc gcgacggtta tttgtcgtaa gaatgctagt      960

atctctgttc gcgctcagga ccgttattac tcatctagtt ggtcggagtg ggcctcggtt     1020

ccctgctctg ggggtggagg atcgggtgga ggtggctcgg gaggtggcgg ctcccgtaat     1080

ttaccggtgg ctactcctga cccagggatg ttcccgtgct tgcaccatag ccaaaactta     1140

cttcgcgctg tcagcaacat gcttcagaaa gcacgtcaaa cgcttgagtt ttacccgtgt     1200

actagcgaag agatcgatca cgaggacatt accaaagaca aaacctccac cgtcgaggcc     1260

tgccttccac ttgaactgac gaaaaatgag tcatgcttaa attctcgtga aacctccttc     1320

attactaacg gatcgtgcct ggcctcgcgc aagacttcgt tcatgatggc attatgcttg     1380

tcgtctattt atgaagacct taaaatgtat caagtggagt tcaagacgat gaatgcaaaa     1440

cttcttatgg acccgaagcg tcaaatcttc ttagaccaaa acatgttggc cgtgatcgat     1500

gaactgatgc aagccttgaa ttttaattcg gaaactgtac cgcaaaaatc ttctcttgaa     1560

gaaccggatt tctataagac caaaattaaa ctttgtattt tacttcacgc tttccgcatc     1620

cgtgcagtaa ctatcgaccg cgtaatgagt taccttaacg cctcgggtgg cgagctcggt     1680

ggcagtggta agcctatccc taaccctctc ctcggcctcg attctacggg atccggtcat     1740

caccaccatc accatcacca t                                               1761


<210> 1151
<211> 1758
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1151
atgatgaagc gtaacatctt agccgttatt gtccccgcat tgcttgtggc cgggacggct       60

aacgcagtcg actataagga tgacgacgac aagcaattgg gcggtggcat ctgggagctt      120

aagaaggacg tgtatgtagt ggagttagac tggtatccag atgcccccgg agagatggtg      180

gtcttaacat gtgacactcc agaggaggac gggattacct ggacacttga ccagtcaagc      240

gaggtattgg gttctggaaa gacgcttact attcaagtca aagaatttgg ggatgccggg      300

cagtatacat gtcacaaggg cggcgaagtt ctgtcgcact ccttactttt gttacacaaa      360

aaagaagacg gcatttggtc cacagacatc cttaaggacc aaaaggagcc gaagaataag      420

acgtttctgc gctgtgaagc gaagaactat agtggtcgct ttacttgctg gtggttgacg      480

accatttcca ctgatttaac cttttcggta aagagttctc gcgggagttc cgacccacag      540

ggcgtgactt gtggcgcagc cacactttcg gcggaacgcg ttcgtgggga caataaggaa      600

tacgaatatt cggtcgagtg tcaggaagat tcagcttgcc ctgccgctga ggagtcactt      660

ccgattgaag tgatggttga cgccgtgcac aaattaaagt atgaaaatta cacgtcatct      720

ttctttatcc gtgacattat taagcccgac ccgccaaaga atctgcagct taaacccctg      780

aagaacagcc gccaggtgga agtaagctgg gaatatcctg acacctggtc cactccgcat      840

tcgtatttct cgttgacgtt ttgtgttcag gtgcagggaa agagcaagcg cgaaaagaag      900

gatcgcgtct ttacagacaa aacgtccgcg acggttattt gtcgtaagaa tgctagtatc      960

tctgttcgcg ctcaggaccg ttattactca tctagttggt cggagtgggc ctcggttccc     1020

tgctctgggg gtggaggatc gggtggaggt ggctcgggag gtggcggctc ccgtaattta     1080

ccggtggcta ctcctgaccc agggatgttc ccgtgcttgc accatagcca aaacttactt     1140

cgcgctgtca gcaacatgct tcagaaagca cgtcaaacgc ttgagtttta cccgtgtact     1200

agcgaagaga tcgatcacga ggacattacc aaagacaaaa cctccaccgt cgaggcctgc     1260

cttccacttg aactgacgaa aaatgagtca tgcttaaatt ctcgtgaaac ctccttcatt     1320

actaacggat cgtgcctggc ctcgcgcaag acttcgttca tgatggcatt atgcttgtcg     1380

tctatttatg aagaccttaa aatgtatcaa gtggagttca agacgatgaa tgcaaaactt     1440

cttatggacc cgaagcgtca aatcttctta gaccaaaaca tgttggccgt gatcgatgaa     1500

ctgatgcaag ccttgaattt taattcggaa actgtaccgc aaaaatcttc tcttgaagaa     1560

ccggatttct ataagaccaa aattaaactt tgtattttac ttcacgcttt ccgcatccgt     1620

gcagtaacta tcgaccgcgt aatgagttac cttaacgcct cgggtggcga gctcggtggc     1680

agtggtaagc ctatccctaa ccctctcctc ggcctcgatt ctacgggatc cggtcatcac     1740

caccatcacc atcaccat                                                   1758


<210> 1152
<211> 1755
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1152
atgaagaaga ctgccatcgc tattgccgtc gcccttgcgg gtttcgcaac cgtggcgcaa       60

gcagtcgact ataaggatga cgacgacaag caattgggcg gtggcatctg ggagcttaag      120

aaggacgtgt atgtagtgga gttagactgg tatccagatg cccccggaga gatggtggtc      180

ttaacatgtg acactccaga ggaggacggg attacctgga cacttgacca gtcaagcgag      240

gtattgggtt ctggaaagac gcttactatt caagtcaaag aatttgggga tgccgggcag      300

tatacatgtc acaagggcgg cgaagttctg tcgcactcct tacttttgtt acacaaaaaa      360

gaagacggca tttggtccac agacatcctt aaggaccaaa aggagccgaa gaataagacg      420

tttctgcgct gtgaagcgaa gaactatagt ggtcgcttta cttgctggtg gttgacgacc      480

atttccactg atttaacctt ttcggtaaag agttctcgcg ggagttccga cccacagggc      540

gtgacttgtg gcgcagccac actttcggcg gaacgcgttc gtggggacaa taaggaatac      600

gaatattcgg tcgagtgtca ggaagattca gcttgccctg ccgctgagga gtcacttccg      660

attgaagtga tggttgacgc cgtgcacaaa ttaaagtatg aaaattacac gtcatctttc      720

tttatccgtg acattattaa gcccgacccg ccaaagaatc tgcagcttaa acccctgaag      780

aacagccgcc aggtggaagt aagctgggaa tatcctgaca cctggtccac tccgcattcg      840

tatttctcgt tgacgttttg tgttcaggtg cagggaaaga gcaagcgcga aaagaaggat      900

cgcgtcttta cagacaaaac gtccgcgacg gttatttgtc gtaagaatgc tagtatctct      960

gttcgcgctc aggaccgtta ttactcatct agttggtcgg agtgggcctc ggttccctgc     1020

tctgggggtg gaggatcggg tggaggtggc tcgggaggtg gcggctcccg taatttaccg     1080

gtggctactc ctgacccagg gatgttcccg tgcttgcacc atagccaaaa cttacttcgc     1140

gctgtcagca acatgcttca gaaagcacgt caaacgcttg agttttaccc gtgtactagc     1200

gaagagatcg atcacgagga cattaccaaa gacaaaacct ccaccgtcga ggcctgcctt     1260

ccacttgaac tgacgaaaaa tgagtcatgc ttaaattctc gtgaaacctc cttcattact     1320

aacggatcgt gcctggcctc gcgcaagact tcgttcatga tggcattatg cttgtcgtct     1380

atttatgaag accttaaaat gtatcaagtg gagttcaaga cgatgaatgc aaaacttctt     1440

atggacccga agcgtcaaat cttcttagac caaaacatgt tggccgtgat cgatgaactg     1500

atgcaagcct tgaattttaa ttcggaaact gtaccgcaaa aatcttctct tgaagaaccg     1560

gatttctata agaccaaaat taaactttgt attttacttc acgctttccg catccgtgca     1620

gtaactatcg accgcgtaat gagttacctt aacgcctcgg gtggcgagct cggtggcagt     1680

ggtaagccta tccctaaccc tctcctcggc ctcgattcta cgggatccgg tcatcaccac     1740

catcaccatc accat                                                      1755


<210> 1153
<211> 1746
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1153
atgcgcgtgt tattgttctt gctgctgagc ttgtttatgt taccagcttt cagtgtcgac       60

tataaggatg acgacgacaa gcaattgggc ggtggcatct gggagcttaa gaaggacgtg      120

tatgtagtgg agttagactg gtatccagat gcccccggag agatggtggt cttaacatgt      180

gacactccag aggaggacgg gattacctgg acacttgacc agtcaagcga ggtattgggt      240

tctggaaaga cgcttactat tcaagtcaaa gaatttgggg atgccgggca gtatacatgt      300

cacaagggcg gcgaagttct gtcgcactcc ttacttttgt tacacaaaaa agaagacggc      360

atttggtcca cagacatcct taaggaccaa aaggagccga agaataagac gtttctgcgc      420

tgtgaagcga agaactatag tggtcgcttt acttgctggt ggttgacgac catttccact      480

gatttaacct tttcggtaaa gagttctcgc gggagttccg acccacaggg cgtgacttgt      540

ggcgcagcca cactttcggc ggaacgcgtt cgtggggaca ataaggaata cgaatattcg      600

gtcgagtgtc aggaagattc agcttgccct gccgctgagg agtcacttcc gattgaagtg      660

atggttgacg ccgtgcacaa attaaagtat gaaaattaca cgtcatcttt ctttatccgt      720

gacattatta agcccgaccc gccaaagaat ctgcagctta aacccctgaa gaacagccgc      780

caggtggaag taagctggga atatcctgac acctggtcca ctccgcattc gtatttctcg      840

ttgacgtttt gtgttcaggt gcagggaaag agcaagcgcg aaaagaagga tcgcgtcttt      900

acagacaaaa cgtccgcgac ggttatttgt cgtaagaatg ctagtatctc tgttcgcgct      960

caggaccgtt attactcatc tagttggtcg gagtgggcct cggttccctg ctctgggggt     1020

ggaggatcgg gtggaggtgg ctcgggaggt ggcggctccc gtaatttacc ggtggctact     1080

cctgacccag ggatgttccc gtgcttgcac catagccaaa acttacttcg cgctgtcagc     1140

aacatgcttc agaaagcacg tcaaacgctt gagttttacc cgtgtactag cgaagagatc     1200

gatcacgagg acattaccaa agacaaaacc tccaccgtcg aggcctgcct tccacttgaa     1260

ctgacgaaaa atgagtcatg cttaaattct cgtgaaacct ccttcattac taacggatcg     1320

tgcctggcct cgcgcaagac ttcgttcatg atggcattat gcttgtcgtc tatttatgaa     1380

gaccttaaaa tgtatcaagt ggagttcaag acgatgaatg caaaacttct tatggacccg     1440

aagcgtcaaa tcttcttaga ccaaaacatg ttggccgtga tcgatgaact gatgcaagcc     1500

ttgaatttta attcggaaac tgtaccgcaa aaatcttctc ttgaagaacc ggatttctat     1560

aagaccaaaa ttaaactttg tattttactt cacgctttcc gcatccgtgc agtaactatc     1620

gaccgcgtaa tgagttacct taacgcctcg ggtggcgagc tcggtggcag tggtaagcct     1680

atccctaacc ctctcctcgg cctcgattct acgggatccg gtcatcacca ccatcaccat     1740

caccat                                                                1746


<210> 1154
<211> 1767
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1154
atgatgatta ccttacgcaa gttgcccctt gcggtagccg ttgctgctgg tgtgatgtcc       60

gcgcaagcaa tggctgtcga ctataaggat gacgacgaca agcaattggg cggtggcatc      120

tgggagctta agaaggacgt gtatgtagtg gagttagact ggtatccaga tgcccccgga      180

gagatggtgg tcttaacatg tgacactcca gaggaggacg ggattacctg gacacttgac      240

cagtcaagcg aggtattggg ttctggaaag acgcttacta ttcaagtcaa agaatttggg      300

gatgccgggc agtatacatg tcacaagggc ggcgaagttc tgtcgcactc cttacttttg      360

ttacacaaaa aagaagacgg catttggtcc acagacatcc ttaaggacca aaaggagccg      420

aagaataaga cgtttctgcg ctgtgaagcg aagaactata gtggtcgctt tacttgctgg      480

tggttgacga ccatttccac tgatttaacc ttttcggtaa agagttctcg cgggagttcc      540

gacccacagg gcgtgacttg tggcgcagcc acactttcgg cggaacgcgt tcgtggggac      600

aataaggaat acgaatattc ggtcgagtgt caggaagatt cagcttgccc tgccgctgag      660

gagtcacttc cgattgaagt gatggttgac gccgtgcaca aattaaagta tgaaaattac      720

acgtcatctt tctttatccg tgacattatt aagcccgacc cgccaaagaa tctgcagctt      780

aaacccctga agaacagccg ccaggtggaa gtaagctggg aatatcctga cacctggtcc      840

actccgcatt cgtatttctc gttgacgttt tgtgttcagg tgcagggaaa gagcaagcgc      900

gaaaagaagg atcgcgtctt tacagacaaa acgtccgcga cggttatttg tcgtaagaat      960

gctagtatct ctgttcgcgc tcaggaccgt tattactcat ctagttggtc ggagtgggcc     1020

tcggttccct gctctggggg tggaggatcg ggtggaggtg gctcgggagg tggcggctcc     1080

cgtaatttac cggtggctac tcctgaccca gggatgttcc cgtgcttgca ccatagccaa     1140

aacttacttc gcgctgtcag caacatgctt cagaaagcac gtcaaacgct tgagttttac     1200

ccgtgtacta gcgaagagat cgatcacgag gacattacca aagacaaaac ctccaccgtc     1260

gaggcctgcc ttccacttga actgacgaaa aatgagtcat gcttaaattc tcgtgaaacc     1320

tccttcatta ctaacggatc gtgcctggcc tcgcgcaaga cttcgttcat gatggcatta     1380

tgcttgtcgt ctatttatga agaccttaaa atgtatcaag tggagttcaa gacgatgaat     1440

gcaaaacttc ttatggaccc gaagcgtcaa atcttcttag accaaaacat gttggccgtg     1500

atcgatgaac tgatgcaagc cttgaatttt aattcggaaa ctgtaccgca aaaatcttct     1560

cttgaagaac cggatttcta taagaccaaa attaaacttt gtattttact tcacgctttc     1620

cgcatccgtg cagtaactat cgaccgcgta atgagttacc ttaacgcctc gggtggcgag     1680

ctcggtggca gtggtaagcc tatccctaac cctctcctcg gcctcgattc tacgggatcc     1740

ggtcatcacc accatcacca tcaccat                                         1767


<210> 1155

<400> 1155
000


<210> 1156
<211> 1758
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1156
atgaaatatc ttcttccaac ggctgctgct ggtttattgc ttcttgccgc ccagcctgcg       60

atggctgtcg actataagga tgacgacgac aagcaattgg gcggtggcat ctgggagctt      120

aagaaggacg tgtatgtagt ggagttagac tggtatccag atgcccccgg agagatggtg      180

gtcttaacat gtgacactcc agaggaggac gggattacct ggacacttga ccagtcaagc      240

gaggtattgg gttctggaaa gacgcttact attcaagtca aagaatttgg ggatgccggg      300

cagtatacat gtcacaaggg cggcgaagtt ctgtcgcact ccttactttt gttacacaaa      360

aaagaagacg gcatttggtc cacagacatc cttaaggacc aaaaggagcc gaagaataag      420

acgtttctgc gctgtgaagc gaagaactat agtggtcgct ttacttgctg gtggttgacg      480

accatttcca ctgatttaac cttttcggta aagagttctc gcgggagttc cgacccacag      540

ggcgtgactt gtggcgcagc cacactttcg gcggaacgcg ttcgtgggga caataaggaa      600

tacgaatatt cggtcgagtg tcaggaagat tcagcttgcc ctgccgctga ggagtcactt      660

ccgattgaag tgatggttga cgccgtgcac aaattaaagt atgaaaatta cacgtcatct      720

ttctttatcc gtgacattat taagcccgac ccgccaaaga atctgcagct taaacccctg      780

aagaacagcc gccaggtgga agtaagctgg gaatatcctg acacctggtc cactccgcat      840

tcgtatttct cgttgacgtt ttgtgttcag gtgcagggaa agagcaagcg cgaaaagaag      900

gatcgcgtct ttacagacaa aacgtccgcg acggttattt gtcgtaagaa tgctagtatc      960

tctgttcgcg ctcaggaccg ttattactca tctagttggt cggagtgggc ctcggttccc     1020

tgctctgggg gtggaggatc gggtggaggt ggctcgggag gtggcggctc ccgtaattta     1080

ccggtggcta ctcctgaccc agggatgttc ccgtgcttgc accatagcca aaacttactt     1140

cgcgctgtca gcaacatgct tcagaaagca cgtcaaacgc ttgagtttta cccgtgtact     1200

agcgaagaga tcgatcacga ggacattacc aaagacaaaa cctccaccgt cgaggcctgc     1260

cttccacttg aactgacgaa aaatgagtca tgcttaaatt ctcgtgaaac ctccttcatt     1320

actaacggat cgtgcctggc ctcgcgcaag acttcgttca tgatggcatt atgcttgtcg     1380

tctatttatg aagaccttaa aatgtatcaa gtggagttca agacgatgaa tgcaaaactt     1440

cttatggacc cgaagcgtca aatcttctta gaccaaaaca tgttggccgt gatcgatgaa     1500

ctgatgcaag ccttgaattt taattcggaa actgtaccgc aaaaatcttc tcttgaagaa     1560

ccggatttct ataagaccaa aattaaactt tgtattttac ttcacgcttt ccgcatccgt     1620

gcagtaacta tcgaccgcgt aatgagttac cttaacgcct cgggtggcga gctcggtggc     1680

agtggtaagc ctatccctaa ccctctcctc ggcctcgatt ctacgggatc cggtcatcac     1740

caccatcacc atcaccat                                                   1758


<210> 1157
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1157
atggggtaca aaatgaacat tagctcgctt cgcaaagcat tcatttttat gggggctgtt       60

gcagctttaa gccttgtcaa tgcccagtca gcgcttgcc                              99


<210> 1158
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1158
atgaaaaaga tttggctggc tcttgccggt ttagtcctgg cattcagcgc aagcgcg          57


<210> 1159
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1159
atgaaacaga gcacaatcgc tttagccttg ctgcctcttc ttttcacgcc tgtcacgaag       60

gca                                                                     63


<210> 1160
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1160
atgaagcagg ctctgcgcgt ggcatttggg ttcctgatct tatgggcgtc cgtcttacac       60

gca                                                                     63


<210> 1161
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1161
atgaaaatca agacgggggc acgcattctt gccttgagcg ccttgacaac gatgatgttc       60

agtgcaagtg cattagcg                                                     78


<210> 1162
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1162
atgaataaga aagtcttgac attgtcggcg gtcatggcct cgatgttgtt cggggcagca       60

gcccacgca                                                               69


<210> 1163
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1163
atgatgaagc gtaacatctt agccgttatt gtccccgcat tgcttgtggc cgggacggct       60

aacgca                                                                  66


<210> 1164
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1164
atgaagaaga ctgccatcgc tattgccgtc gcccttgcgg gtttcgcaac cgtggcgcaa       60

gca                                                                     63


<210> 1165
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1165
atgcgcgtgt tattgttctt gctgctgagc ttgtttatgt taccagcttt cagt             54


<210> 1166
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1166
atgatgatta ccttacgcaa gttgcccctt gcggtagccg ttgctgctgg tgtgatgtcc       60

gcgcaagcaa tggct                                                        75


<210> 1167
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1167
atgaaatatc ttcttccaac ggctgctgct ggtttattgc ttcttgccgc ccagcctgcg       60

atggct                                                                  66


<210> 1168
<211> 1554
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1168
atctgggagc ttaagaagga cgtgtatgta gtggagttag actggtatcc agatgccccc       60

ggagagatgg tggtcttaac atgtgacact ccagaggagg acgggattac ctggacactt      120

gaccagtcaa gcgaggtatt gggttctgga aagacgctta ctattcaagt caaagaattt      180

ggggatgccg ggcagtatac atgtcacaag ggcggcgaag ttctgtcgca ctccttactt      240

ttgttacaca aaaaagaaga cggcatttgg tccacagaca tccttaagga ccaaaaggag      300

ccgaagaata agacgtttct gcgctgtgaa gcgaagaact atagtggtcg ctttacttgc      360

tggtggttga cgaccatttc cactgattta accttttcgg taaagagttc tcgcgggagt      420

tccgacccac agggcgtgac ttgtggcgca gccacacttt cggcggaacg cgttcgtggg      480

gacaataagg aatacgaata ttcggtcgag tgtcaggaag attcagcttg ccctgccgct      540

gaggagtcac ttccgattga agtgatggtt gacgccgtgc acaaattaaa gtatgaaaat      600

tacacgtcat ctttctttat ccgtgacatt attaagcccg acccgccaaa gaatctgcag      660

cttaaacccc tgaagaacag ccgccaggtg gaagtaagct gggaatatcc tgacacctgg      720

tccactccgc attcgtattt ctcgttgacg ttttgtgttc aggtgcaggg aaagagcaag      780

cgcgaaaaga aggatcgcgt ctttacagac aaaacgtccg cgacggttat ttgtcgtaag      840

aatgctagta tctctgttcg cgctcaggac cgttattact catctagttg gtcggagtgg      900

gcctcggttc cctgctctgg gggtggagga tcgggtggag gtggctcggg aggtggcggc      960

tcccgtaatt taccggtggc tactcctgac ccagggatgt tcccgtgctt gcaccatagc     1020

caaaacttac ttcgcgctgt cagcaacatg cttcagaaag cacgtcaaac gcttgagttt     1080

tacccgtgta ctagcgaaga gatcgatcac gaggacatta ccaaagacaa aacctccacc     1140

gtcgaggcct gccttccact tgaactgacg aaaaatgagt catgcttaaa ttctcgtgaa     1200

acctccttca ttactaacgg atcgtgcctg gcctcgcgca agacttcgtt catgatggca     1260

ttatgcttgt cgtctattta tgaagacctt aaaatgtatc aagtggagtt caagacgatg     1320

aatgcaaaac ttcttatgga cccgaagcgt caaatcttct tagaccaaaa catgttggcc     1380

gtgatcgatg aactgatgca agccttgaat tttaattcgg aaactgtacc gcaaaaatct     1440

tctcttgaag aaccggattt ctataagacc aaaattaaac tttgtatttt acttcacgct     1500

ttccgcatcc gtgcagtaac tatcgaccgc gtaatgagtt accttaacgc ctcg           1554


<210> 1169
<211> 597
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1169
Met Gly Tyr Lys Met Asn Ile Ser Ser Leu Arg Lys Ala Phe Ile Phe 
1               5                   10                  15      


Met Gly Ala Val Ala Ala Leu Ser Leu Val Asn Ala Gln Ser Ala Leu 
            20                  25                  30          


Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly Gly Gly Ile 
        35                  40                  45              


Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro 
    50                  55                  60                  


Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu 
65                  70                  75                  80  


Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser 
                85                  90                  95      


Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln 
            100                 105                 110         


Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu 
        115                 120                 125             


Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp 
    130                 135                 140                 


Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn 
145                 150                 155                 160 


Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp 
                165                 170                 175     


Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly 
            180                 185                 190         


Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp 
        195                 200                 205             


Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys 
    210                 215                 220                 


Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val 
225                 230                 235                 240 


His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp 
                245                 250                 255     


Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys 
            260                 265                 270         


Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser 
        275                 280                 285             


Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly 
    290                 295                 300                 


Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser 
305                 310                 315                 320 


Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln 
                325                 330                 335     


Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        355                 360                 365             


Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
    370                 375                 380                 


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
385                 390                 395                 400 


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
                405                 410                 415     


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
            420                 425                 430         


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
        435                 440                 445             


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
    450                 455                 460                 


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
465                 470                 475                 480 


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
                485                 490                 495     


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
            500                 505                 510         


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
        515                 520                 525             


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
    530                 535                 540                 


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
545                 550                 555                 560 


Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser Gly Lys Pro Ile 
                565                 570                 575     


Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His His 
            580                 585                 590         


His His His His His 
        595         


<210> 1170
<211> 583
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1170
Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly Gly 
            20                  25                  30          


Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp 
        35                  40                  45              


Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro 
    50                  55                  60                  


Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu 
65                  70                  75                  80  


Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala 
                85                  90                  95      


Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu 
            100                 105                 110         


Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu 
        115                 120                 125             


Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala 
    130                 135                 140                 


Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser 
145                 150                 155                 160 


Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro 
                165                 170                 175     


Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg 
            180                 185                 190         


Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser 
        195                 200                 205             


Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp 
    210                 215                 220                 


Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
225                 230                 235                 240 


Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
                245                 250                 255     


Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
            260                 265                 270         


Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val 
        275                 280                 285             


Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys 
    290                 295                 300                 


Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg 
305                 310                 315                 320 


Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val 
                325                 330                 335     


Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro 
        355                 360                 365             


Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu 
    370                 375                 380                 


Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
385                 390                 395                 400 


Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
                405                 410                 415     


Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg 
            420                 425                 430         


Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
        435                 440                 445             


Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
    450                 455                 460                 


Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp 
465                 470                 475                 480 


Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp 
                485                 490                 495     


Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys 
            500                 505                 510         


Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
        515                 520                 525             


Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val 
    530                 535                 540                 


Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser Gly Lys 
545                 550                 555                 560 


Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His 
                565                 570                 575     


His His His His His His His 
            580             


<210> 1171
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1171
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
        35                  40                  45              


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
    50                  55                  60                  


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
65                  70                  75                  80  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
                85                  90                  95      


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
            100                 105                 110         


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
        115                 120                 125             


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
    130                 135                 140                 


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
145                 150                 155                 160 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
                165                 170                 175     


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
            180                 185                 190         


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
        195                 200                 205             


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
    210                 215                 220                 


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
225                 230                 235                 240 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
                245                 250                 255     


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
            260                 265                 270         


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
        275                 280                 285             


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
    290                 295                 300                 


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
305                 310                 315                 320 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
                325                 330                 335     


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
        355                 360                 365             


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
    370                 375                 380                 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
385                 390                 395                 400 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
                405                 410                 415     


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
            420                 425                 430         


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
        435                 440                 445             


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
    450                 455                 460                 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
465                 470                 475                 480 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
                485                 490                 495     


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
            500                 505                 510         


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
        515                 520                 525             


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
    530                 535                 540                 


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser 
545                 550                 555                 560 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
                565                 570                 575     


Gly His His His His His His His His 
            580                 585 


<210> 1172
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1172
Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
        35                  40                  45              


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
    50                  55                  60                  


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
65                  70                  75                  80  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
                85                  90                  95      


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
            100                 105                 110         


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
        115                 120                 125             


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
    130                 135                 140                 


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
145                 150                 155                 160 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
                165                 170                 175     


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
            180                 185                 190         


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
        195                 200                 205             


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
    210                 215                 220                 


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
225                 230                 235                 240 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
                245                 250                 255     


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
            260                 265                 270         


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
        275                 280                 285             


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
    290                 295                 300                 


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
305                 310                 315                 320 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
                325                 330                 335     


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
        355                 360                 365             


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
    370                 375                 380                 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
385                 390                 395                 400 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
                405                 410                 415     


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
            420                 425                 430         


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
        435                 440                 445             


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
    450                 455                 460                 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
465                 470                 475                 480 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
                485                 490                 495     


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
            500                 505                 510         


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
        515                 520                 525             


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
    530                 535                 540                 


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser 
545                 550                 555                 560 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
                565                 570                 575     


Gly His His His His His His His His 
            580                 585 


<210> 1173
<211> 590
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1173
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala Val Asp Tyr Lys Asp Asp 
            20                  25                  30          


Asp Asp Lys Gln Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val 
        35                  40                  45              


Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val 
    50                  55                  60                  


Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu 
65                  70                  75                  80  


Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln 
                85                  90                  95      


Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly 
            100                 105                 110         


Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly 
        115                 120                 125             


Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys 
    130                 135                 140                 


Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys 
145                 150                 155                 160 


Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser 
                165                 170                 175     


Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr 
            180                 185                 190         


Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser 
        195                 200                 205             


Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu 
    210                 215                 220                 


Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn 
225                 230                 235                 240 


Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 
                245                 250                 255     


Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val 
            260                 265                 270         


Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser 
        275                 280                 285             


Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys 
    290                 295                 300                 


Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys 
305                 310                 315                 320 


Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser 
                325                 330                 335     


Trp Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr 
        355                 360                 365             


Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu 
    370                 375                 380                 


Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
385                 390                 395                 400 


Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
                405                 410                 415     


Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn 
            420                 425                 430         


Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser 
        435                 440                 445             


Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser 
    450                 455                 460                 


Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met 
465                 470                 475                 480 


Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
                485                 490                 495     


Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn 
            500                 505                 510         


Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
        515                 520                 525             


Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
    530                 535                 540                 


Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly 
545                 550                 555                 560 


Glu Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
                565                 570                 575     


Asp Ser Thr Gly Ser Gly His His His His His His His His 
            580                 585                 590 


<210> 1174
<211> 587
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1174
Met Asn Lys Lys Val Leu Thr Leu Ser Ala Val Met Ala Ser Met Leu 
1               5                   10                  15      


Phe Gly Ala Ala Ala His Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25                  30          


Gln Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val 
        35                  40                  45              


Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr 
    50                  55                  60                  


Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser 
65                  70                  75                  80  


Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu 
                85                  90                  95      


Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu 
            100                 105                 110         


Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser 
        115                 120                 125             


Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu 
    130                 135                 140                 


Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu 
145                 150                 155                 160 


Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly 
                165                 170                 175     


Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala 
            180                 185                 190         


Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys 
        195                 200                 205             


Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu 
    210                 215                 220                 


Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser 
225                 230                 235                 240 


Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu 
                245                 250                 255     


Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu 
            260                 265                 270         


Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe 
        275                 280                 285             


Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val 
    290                 295                 300                 


Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser 
305                 310                 315                 320 


Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu 
                325                 330                 335     


Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
        355                 360                 365             


Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
    370                 375                 380                 


Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
385                 390                 395                 400 


Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
                405                 410                 415     


Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
            420                 425                 430         


Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
        435                 440                 445             


Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
    450                 455                 460                 


Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
465                 470                 475                 480 


Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
                485                 490                 495     


Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
            500                 505                 510         


Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
        515                 520                 525             


Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
    530                 535                 540                 


Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly 
545                 550                 555                 560 


Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
                565                 570                 575     


Gly Ser Gly His His His His His His His His 
            580                 585         


<210> 1175
<211> 586
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1175
Met Met Lys Arg Asn Ile Leu Ala Val Ile Val Pro Ala Leu Leu Val 
1               5                   10                  15      


Ala Gly Thr Ala Asn Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln 
            20                  25                  30          


Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
        35                  40                  45              


Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
    50                  55                  60                  


Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
65                  70                  75                  80  


Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
                85                  90                  95      


Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
            100                 105                 110         


His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
        115                 120                 125             


Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
    130                 135                 140                 


Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
145                 150                 155                 160 


Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
                165                 170                 175     


Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
            180                 185                 190         


Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
        195                 200                 205             


Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
    210                 215                 220                 


Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
225                 230                 235                 240 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
                245                 250                 255     


Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
            260                 265                 270         


Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
        275                 280                 285             


Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
    290                 295                 300                 


Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
305                 310                 315                 320 


Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
                325                 330                 335     


Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly 
545                 550                 555                 560 


Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly 
                565                 570                 575     


Ser Gly His His His His His His His His 
            580                 585     


<210> 1176
<211> 585
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1176
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu 
            20                  25                  30          


Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
        35                  40                  45              


Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
    50                  55                  60                  


Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
65                  70                  75                  80  


Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
                85                  90                  95      


Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
            100                 105                 110         


Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
        115                 120                 125             


Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
    130                 135                 140                 


Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
145                 150                 155                 160 


Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
                165                 170                 175     


Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
            180                 185                 190         


Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
        195                 200                 205             


Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
    210                 215                 220                 


Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
225                 230                 235                 240 


Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
                245                 250                 255     


Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
            260                 265                 270         


Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
        275                 280                 285             


Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
    290                 295                 300                 


Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
305                 310                 315                 320 


Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
                325                 330                 335     


Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
        355                 360                 365             


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
    370                 375                 380                 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
385                 390                 395                 400 


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
                405                 410                 415     


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
            420                 425                 430         


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
        435                 440                 445             


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
    450                 455                 460                 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
465                 470                 475                 480 


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
                485                 490                 495     


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
            500                 505                 510         


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
        515                 520                 525             


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
    530                 535                 540                 


Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser 
545                 550                 555                 560 


Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser 
                565                 570                 575     


Gly His His His His His His His His 
            580                 585 


<210> 1177
<211> 582
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1177
Met Arg Val Leu Leu Phe Leu Leu Leu Ser Leu Phe Met Leu Pro Ala 
1               5                   10                  15      


Phe Ser Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln Leu Gly Gly Gly 
            20                  25                  30          


Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
        35                  40                  45              


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
    50                  55                  60                  


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
65                  70                  75                  80  


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
                85                  90                  95      


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
            100                 105                 110         


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
        115                 120                 125             


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
    130                 135                 140                 


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
145                 150                 155                 160 


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
                165                 170                 175     


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
            180                 185                 190         


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
        195                 200                 205             


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
    210                 215                 220                 


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
225                 230                 235                 240 


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
                245                 250                 255     


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
            260                 265                 270         


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
        275                 280                 285             


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
    290                 295                 300                 


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
305                 310                 315                 320 


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
                325                 330                 335     


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            340                 345                 350         


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
        355                 360                 365             


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
    370                 375                 380                 


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
385                 390                 395                 400 


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
                405                 410                 415     


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
            420                 425                 430         


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
        435                 440                 445             


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
    450                 455                 460                 


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
465                 470                 475                 480 


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
                485                 490                 495     


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
            500                 505                 510         


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
        515                 520                 525             


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
    530                 535                 540                 


Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly Ser Gly Lys Pro 
545                 550                 555                 560 


Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly Ser Gly His His 
                565                 570                 575     


His His His His His His 
            580         


<210> 1178
<211> 589
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1178
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala Val Asp Tyr Lys Asp Asp Asp 
            20                  25                  30          


Asp Lys Gln Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr 
        35                  40                  45              


Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val 
    50                  55                  60                  


Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp 
65                  70                  75                  80  


Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val 
                85                  90                  95      


Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
            100                 105                 110         


Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile 
        115                 120                 125             


Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr 
    130                 135                 140                 


Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp 
145                 150                 155                 160 


Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser 
                165                 170                 175     


Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu 
            180                 185                 190         


Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val 
        195                 200                 205             


Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
    210                 215                 220                 


Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
225                 230                 235                 240 


Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
                245                 250                 255     


Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
            260                 265                 270         


Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
        275                 280                 285             


Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp 
    290                 295                 300                 


Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn 
305                 310                 315                 320 


Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp 
                325                 330                 335     


Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro 
        355                 360                 365             


Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg 
    370                 375                 380                 


Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr 
385                 390                 395                 400 


Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys 
                405                 410                 415     


Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu 
            420                 425                 430         


Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys 
        435                 440                 445             


Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser 
    450                 455                 460                 


Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn 
465                 470                 475                 480 


Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn 
                485                 490                 495     


Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser 
            500                 505                 510         


Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys 
        515                 520                 525             


Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala 
    530                 535                 540                 


Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu 
545                 550                 555                 560 


Leu Gly Gly Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp 
                565                 570                 575     


Ser Thr Gly Ser Gly His His His His His His His His 
            580                 585                 


<210> 1179
<211> 586
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1179
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Val Asp Tyr Lys Asp Asp Asp Asp Lys Gln 
            20                  25                  30          


Leu Gly Gly Gly Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
        35                  40                  45              


Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
    50                  55                  60                  


Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
65                  70                  75                  80  


Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
                85                  90                  95      


Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
            100                 105                 110         


His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
        115                 120                 125             


Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
    130                 135                 140                 


Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
145                 150                 155                 160 


Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
                165                 170                 175     


Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
            180                 185                 190         


Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
        195                 200                 205             


Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
    210                 215                 220                 


Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
225                 230                 235                 240 


Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
                245                 250                 255     


Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
            260                 265                 270         


Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
        275                 280                 285             


Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
    290                 295                 300                 


Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
305                 310                 315                 320 


Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
                325                 330                 335     


Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly 
        355                 360                 365             


Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser 
    370                 375                 380                 


Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr 
385                 390                 395                 400 


Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr 
                405                 410                 415     


Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu 
            420                 425                 430         


Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser 
        435                 440                 445             


Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu 
    450                 455                 460                 


Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu 
465                 470                 475                 480 


Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala 
                485                 490                 495     


Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val 
            500                 505                 510         


Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile 
        515                 520                 525             


Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile 
    530                 535                 540                 


Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Glu Leu Gly Gly 
545                 550                 555                 560 


Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr Gly 
                565                 570                 575     


Ser Gly His His His His His His His His 
            580                 585     


<210> 1180
<211> 33
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1180
Met Gly Tyr Lys Met Asn Ile Ser Ser Leu Arg Lys Ala Phe Ile Phe 
1               5                   10                  15      


Met Gly Ala Val Ala Ala Leu Ser Leu Val Asn Ala Gln Ser Ala Leu 
            20                  25                  30          


Ala 
    


<210> 1181
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1181
Met Lys Lys Ile Trp Leu Ala Leu Ala Gly Leu Val Leu Ala Phe Ser 
1               5                   10                  15      


Ala Ser Ala 
            


<210> 1182
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1182
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala 
            20      


<210> 1183
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1183
Met Lys Gln Ala Leu Arg Val Ala Phe Gly Phe Leu Ile Leu Trp Ala 
1               5                   10                  15      


Ser Val Leu His Ala 
            20      


<210> 1184
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1184
Met Lys Ile Lys Thr Gly Ala Arg Ile Leu Ala Leu Ser Ala Leu Thr 
1               5                   10                  15      


Thr Met Met Phe Ser Ala Ser Ala Leu Ala 
            20                  25      


<210> 1185
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1185
Met Asn Lys Lys Val Leu Thr Leu Ser Ala Val Met Ala Ser Met Leu 
1               5                   10                  15      


Phe Gly Ala Ala Ala His Ala 
            20              


<210> 1186
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1186
Met Thr Asn Ile Thr Lys Arg Ser Leu Val Ala Ala Gly Val Leu Ala 
1               5                   10                  15      


Ala Leu Met Ala Gly Asn Val Ala Leu Ala 
            20                  25      


<210> 1187
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1187
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala 
            20      


<210> 1188
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1188
Met Arg Val Leu Leu Phe Leu Leu Leu Ser Leu Phe Met Leu Pro Ala 
1               5                   10                  15      


Phe Ser 
        


<210> 1189
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1189
Met Met Ile Thr Leu Arg Lys Leu Pro Leu Ala Val Ala Val Ala Ala 
1               5                   10                  15      


Gly Val Met Ser Ala Gln Ala Met Ala 
            20                  25  


<210> 1190
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1190
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210> 1191
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1191
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     


Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         


Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             


Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 


Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 


Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     


Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         


Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             


Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 


Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     


Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         


Ser Tyr Leu Asn Ala Ser 
        515             


<210> 1192
<211> 305
<212> PRT
<213> Homo sapiens

<400> 1192
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys 
305 


<210> 1193
<211> 197
<212> PRT
<213> Homo sapiens

<400> 1193
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210> 1194
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1194
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 1195
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1195
atggggtaca aaatgaacat tagctcgctt cgcaaagcat tcatttttat gggggctgtt       60

gcagctttaa gccttgtcaa tgcccagtca gcgcttgcca tgatcacttg tccgcccccc      120

atgtctgtgg aacacgcgga tatttgggta aagagctact cactgtacag ccgtgaacgt      180

tatatttgta actccggctt caaacgcaaa gcaggaactt catcactgac ggagtgtgtt      240

ttaaataaag ctactaacgt cgcgcactgg actactccct cattgaagtg catccgtgat      300

cctgctctgg gtggcggggg tagcggcggg ggtggaagcg ggggtggagg gtctggagga      360

ggtgggtcta actgggtgaa tgttatctca gatttaaaga aaattgaaga cctgatccaa      420

tctatgcaca tcgacgctac tctgtataca gaatcagatg tacatccttc gtgtaaagtg      480

accgcgatga agtgtttttt gcttgagctg caagtaattt cccttgagtc cggggacgct      540

tcaatccatg acacggtcga gaacctgatc attctggcaa acaatagttt atcatcgaac      600

ggtaatgtta ccgaatcggg ttgcaaagaa tgcgaagagt tagaggaaaa gaacattaaa      660

gaatttttgc aatccttcgt tcacattgtg cagatgttca ttaatacatc g               711


<210> 1196
<211> 666
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1196
atgcgcgtgt tattgttctt gctgctgagc ttgtttatgt taccagcttt cagtatgatc       60

acttgtccgc cccccatgtc tgtggaacac gcggatattt gggtaaagag ctactcactg      120

tacagccgtg aacgttatat ttgtaactcc ggcttcaaac gcaaagcagg aacttcatca      180

ctgacggagt gtgttttaaa taaagctact aacgtcgcgc actggactac tccctcattg      240

aagtgcatcc gtgatcctgc tctgggtggc gggggtagcg gcgggggtgg aagcgggggt      300

ggagggtctg gaggaggtgg gtctaactgg gtgaatgtta tctcagattt aaagaaaatt      360

gaagacctga tccaatctat gcacatcgac gctactctgt atacagaatc agatgtacat      420

ccttcgtgta aagtgaccgc gatgaagtgt tttttgcttg agctgcaagt aatttccctt      480

gagtccgggg acgcttcaat ccatgacacg gtcgagaacc tgatcattct ggcaaacaat      540

agtttatcat cgaacggtaa tgttaccgaa tcgggttgca aagaatgcga agagttagag      600

gaaaagaaca ttaaagaatt tttgcaatcc ttcgttcaca ttgtgcagat gttcattaat      660

acatcg                                                                 666


<210> 1197
<211> 678
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1197
atgaaatatc ttcttccaac ggctgctgct ggtttattgc ttcttgccgc ccagcctgcg       60

atggctatga tcacttgtcc gccccccatg tctgtggaac acgcggatat ttgggtaaag      120

agctactcac tgtacagccg tgaacgttat atttgtaact ccggcttcaa acgcaaagca      180

ggaacttcat cactgacgga gtgtgtttta aataaagcta ctaacgtcgc gcactggact      240

actccctcat tgaagtgcat ccgtgatcct gctctgggtg gcgggggtag cggcgggggt      300

ggaagcgggg gtggagggtc tggaggaggt gggtctaact gggtgaatgt tatctcagat      360

ttaaagaaaa ttgaagacct gatccaatct atgcacatcg acgctactct gtatacagaa      420

tcagatgtac atccttcgtg taaagtgacc gcgatgaagt gttttttgct tgagctgcaa      480

gtaatttccc ttgagtccgg ggacgcttca atccatgaca cggtcgagaa cctgatcatt      540

ctggcaaaca atagtttatc atcgaacggt aatgttaccg aatcgggttg caaagaatgc      600

gaagagttag aggaaaagaa cattaaagaa tttttgcaat ccttcgttca cattgtgcag      660

atgttcatta atacatcg                                                    678


<210> 1198
<211> 612
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1198
atgatcactt gtccgccccc catgtctgtg gaacacgcgg atatttgggt aaagagctac       60

tcactgtaca gccgtgaacg ttatatttgt aactccggct tcaaacgcaa agcaggaact      120

tcatcactga cggagtgtgt tttaaataaa gctactaacg tcgcgcactg gactactccc      180

tcattgaagt gcatccgtga tcctgctctg ggtggcgggg gtagcggcgg gggtggaagc      240

gggggtggag ggtctggagg aggtgggtct aactgggtga atgttatctc agatttaaag      300

aaaattgaag acctgatcca atctatgcac atcgacgcta ctctgtatac agaatcagat      360

gtacatcctt cgtgtaaagt gaccgcgatg aagtgttttt tgcttgagct gcaagtaatt      420

tcccttgagt ccggggacgc ttcaatccat gacacggtcg agaacctgat cattctggca      480

aacaatagtt tatcatcgaa cggtaatgtt accgaatcgg gttgcaaaga atgcgaagag      540

ttagaggaaa agaacattaa agaatttttg caatccttcg ttcacattgt gcagatgttc      600

attaatacat cg                                                          612


<210> 1199
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1199
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 1200
<211> 237
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1200
Met Gly Tyr Lys Met Asn Ile Ser Ser Leu Arg Lys Ala Phe Ile Phe 
1               5                   10                  15      


Met Gly Ala Val Ala Ala Leu Ser Leu Val Asn Ala Gln Ser Ala Leu 
            20                  25                  30          


Ala Met Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        35                  40                  45              


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    50                  55                  60                  


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
65                  70                  75                  80  


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                85                  90                  95      


Cys Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
        115                 120                 125             


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
    130                 135                 140                 


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
145                 150                 155                 160 


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                165                 170                 175     


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
            180                 185                 190         


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
        195                 200                 205             


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
    210                 215                 220                 


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
225                 230                 235         


<210> 1201
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1201
Met Arg Val Leu Leu Phe Leu Leu Leu Ser Leu Phe Met Leu Pro Ala 
1               5                   10                  15      


Phe Ser Met Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp 
            20                  25                  30          


Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys 
        35                  40                  45              


Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys 
    50                  55                  60                  


Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu 
65                  70                  75                  80  


Lys Cys Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn 
            100                 105                 110         


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
        115                 120                 125             


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
    130                 135                 140                 


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
145                 150                 155                 160 


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
                165                 170                 175     


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
            180                 185                 190         


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
        195                 200                 205             


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
    210                 215                 220         


<210> 1202
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1202
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Met Ile Thr Cys Pro Pro Pro Met Ser Val 
            20                  25                  30          


Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu 
        35                  40                  45              


Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser 
    50                  55                  60                  


Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr 
65                  70                  75                  80  


Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly 
                85                  90                  95      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            100                 105                 110         


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
        115                 120                 125             


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
    130                 135                 140                 


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
145                 150                 155                 160 


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
                165                 170                 175     


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
            180                 185                 190         


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
        195                 200                 205             


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
    210                 215                 220                 


Thr Ser 
225     


<210> 1203
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1203
Met Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
1               5                   10                  15      


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
            20                  25                  30          


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
        35                  40                  45              


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
    50                  55                  60                  


Ile Arg Asp Pro Ala Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile 
                85                  90                  95      


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
            100                 105                 110         


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
        115                 120                 125             


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
    130                 135                 140                 


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
145                 150                 155                 160 


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
                165                 170                 175     


Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser 
            180                 185                 190         


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        195                 200                 


<210> 1204
<211> 114
<212> PRT
<213> Homo sapiens

<400> 1204
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210> 1205
<211> 73
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1205
Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser Asn 
1               5                   10                  15      


Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro Ala 
            20                  25                  30          


Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys Lys 
        35                  40                  45              


Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn Leu 
    50                  55                  60                  


Leu Lys Ala Val Ser Lys Glu Arg Ser 
65                  70              


<210> 1206
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1206
Met Lys Gln Ser Thr Ile Ala Leu Ala Leu Leu Pro Leu Leu Phe Thr 
1               5                   10                  15      


Pro Val Thr Lys Ala Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser 
                85                  90                  


<210> 1207
<211> 222
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1207
gtgcccctga gccgcaccgt gcgttgtacg tgtatctcca tctcaaacca gccggtaaac       60

ccgcgtagtt tagaaaaact ggagattatc ccagccagcc agttttgccc gcgcgttgag      120

attattgcga ccatgaagaa aaaaggggaa aaacgttgcc ttaatccaga aagtaaggct      180

atcaaaaacc tgttgaaagc tgtctcgaaa gagcgttcct aa                         222


<210> 1208
<211> 285
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1208
atgaagcaaa gtacgatcgc ccttgcgctg ttgccccttc ttttcacgcc cgtcaccaag       60

gcagtgcccc tgagccgcac cgtgcgttgt acgtgtatct ccatctcaaa ccagccggta      120

aacccgcgta gtttagaaaa actggagatt atcccagcca gccagttttg cccgcgcgtt      180

gagattattg cgaccatgaa gaaaaaaggg gaaaaacgtt gccttaatcc agaaagtaag      240

gctatcaaaa acctgttgaa agctgtctcg aaagagcgtt cctaa                      285


<210> 1209
<211> 273
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1209
Met Asp Phe Ser Asn Met Ser Ile Leu His Tyr Leu Ala Asn Ile Val 
1               5                   10                  15      


Asp Ile Leu Val Val Trp Phe Val Ile Tyr Lys Val Ile Met Leu Ile 
            20                  25                  30          


Arg Gly Thr Lys Ala Val Gln Leu Leu Lys Gly Ile Phe Ile Ile Ile 
        35                  40                  45              


Ala Val Lys Leu Leu Ser Gly Phe Phe Gly Leu Gln Thr Val Glu Trp 
    50                  55                  60                  


Ile Thr Asp Gln Met Leu Thr Trp Gly Phe Leu Ala Ile Ile Ile Ile 
65                  70                  75                  80  


Phe Gln Pro Glu Leu Arg Arg Ala Leu Glu Thr Leu Gly Arg Gly Asn 
                85                  90                  95      


Ile Phe Thr Arg Tyr Gly Ser Arg Ile Glu Arg Glu Gln His His Leu 
            100                 105                 110         


Ile Glu Ser Ile Glu Lys Ser Thr Gln Tyr Met Ala Lys Arg Arg Ile 
        115                 120                 125             


Gly Ala Leu Ile Ser Val Ala Arg Asp Thr Gly Met Asp Asp Tyr Ile 
    130                 135                 140                 


Glu Thr Gly Ile Pro Leu Asn Ala Lys Ile Ser Ser Gln Leu Leu Ile 
145                 150                 155                 160 


Asn Ile Phe Ile Pro Asn Thr Pro Leu His Asp Gly Ala Val Ile Ile 
                165                 170                 175     


Lys Gly Asn Glu Ile Ala Ser Ala Ala Ser Tyr Leu Pro Leu Ser Asp 
            180                 185                 190         


Ser Pro Phe Leu Ser Lys Glu Leu Gly Thr Arg His Arg Ala Ala Leu 
        195                 200                 205             


Gly Ile Ser Glu Val Thr Asp Ser Ile Thr Ile Val Val Ser Glu Glu 
    210                 215                 220                 


Thr Gly Gly Ile Ser Leu Thr Lys Gly Gly Glu Leu Phe Arg Asp Val 
225                 230                 235                 240 


Ser Glu Glu Glu Leu His Lys Ile Leu Leu Lys Glu Leu Val Thr Val 
                245                 250                 255     


Thr Ala Lys Lys Pro Ser Ile Phe Ser Lys Trp Lys Gly Gly Lys Ser 
            260                 265                 270         


Glu 
    


<210> 1210
<211> 822
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1210
atggactttt ccaacatgag tatccttcac tatttagcga atattgtaga cattttggtg       60

gtttggttcg taatttacaa ggttatcatg cttatccgcg gcacgaaagc cgtccagctg      120

ttgaagggga ttttcattat tattgccgtc aagttactta gcggcttctt cggattgcag      180

acagtggaat ggattactga tcaaatgctg acttggggtt tcttagccat tatcattatc      240

tttcaaccgg aattgcgtcg tgccctggag actttggggc gtggcaatat ctttacccgc      300

tatggatcac gcattgagcg tgaacaacac caccttattg agtctattga aaagtccacg      360

caatacatgg cgaagcgtcg cattggagct ttgatctctg tggctcgtga tacaggcatg      420

gacgactaca tcgagactgg cattccgctt aatgcgaaaa tctcatcgca attattgatt      480

aatatcttca tccccaatac ccctcttcac gatggcgcag tgatcattaa aggtaacgag      540

atcgcgagcg ctgccagtta tctgccattg tccgactcgc cgtttctttc taaggagctg      600

ggaactcgcc atcgtgccgc attagggatt tccgaggtga cagattcaat cacaatcgtt      660

gtcagcgagg aaacaggtgg gatttccctt acgaagggag gcgaactgtt ccgtgatgta      720

tccgaagaag aattgcataa gattttgctt aaagagctgg tgactgtcac agctaaaaaa      780

ccaagcattt tctccaaatg gaaaggaggt aagtccgagt ga                         822


<210> 1211
<211> 3787
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1211
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaacccgcat cccacgctaa     1620

ctaatataag gggggcaaga atggactttt ccaacatgag tatccttcac tatttagcga     1680

atattgtaga cattttggtg gtttggttcg taatttacaa ggttatcatg cttatccgcg     1740

gcacgaaagc cgtccagctg ttgaagggga ttttcattat tattgccgtc aagttactta     1800

gcggcttctt cggattgcag acagtggaat ggattactga tcaaatgctg acttggggtt     1860

tcttagccat tatcattatc tttcaaccgg aattgcgtcg tgccctggag actttggggc     1920

gtggcaatat ctttacccgc tatggatcac gcattgagcg tgaacaacac caccttattg     1980

agtctattga aaagtccacg caatacatgg cgaagcgtcg cattggagct ttgatctctg     2040

tggctcgtga tacaggcatg gacgactaca tcgagactgg cattccgctt aatgcgaaaa     2100

tctcatcgca attattgatt aatatcttca tccccaatac ccctcttcac gatggcgcag     2160

tgatcattaa aggtaacgag atcgcgagcg ctgccagtta tctgccattg tccgactcgc     2220

cgtttctttc taaggagctg ggaactcgcc atcgtgccgc attagggatt tccgaggtga     2280

cagattcaat cacaatcgtt gtcagcgagg aaacaggtgg gatttccctt acgaagggag     2340

gcgaactgtt ccgtgatgta tccgaagaag aattgcataa gattttgctt aaagagctgg     2400

tgactgtcac agctaaaaaa ccaagcattt tctccaaatg gaaaggaggt aagtccgagt     2460

gaggaggaac gattggtaaa cccggtgaac gcatgagaaa gcccccggaa gatcaccttc     2520

cgggggcttt tttattgcgc ggaccaaaac gaaaaaagac gctcgaaagc gtctcttttc     2580

tggaatttgg taccgaggcg taatgctctg ccagtgttac aaccaattaa ccaattctga     2640

ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat     2700

accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca     2760

taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc     2820

tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac     2880

tgaatccggt gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca     2940

gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg     3000

cgcctgagcg agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga     3060

atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata     3120

ttcttctaat acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc     3180

atcaggagta cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt     3240

tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa     3300

caactctggc gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac     3360

attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg     3420

cctcgagcaa gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat     3480

gtaagcagac agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca     3540

gagattttga gacacaacgt ggctttgttg aataaatcga acttttgctg agttgaagga     3600

tcagatcacg catcttcccg acaacgcaga ccgttccgtg gcaaagcaaa agttcaaaat     3660

caccaactgg tccacctaca acaaagctct catcaaccgt ggctccctca ctttctggct     3720

ggatgatggg gcgattcagg cctggtatga gtcagcaaca ccttcttcac gaggcagacc     3780

tcagcgc                                                               3787


<210> 1212
<211> 5519
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1212
agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc       60

acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc      120

tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa      180

ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac gccaagctat      240

ttaggtgaca ctatagaata ctcaagctat gcatcaagct tggtaccgag ctcggatcca      300

ctagtaacgg ccgccagtgt gctggaattc gcccttttaa gacccacttt cacatttaag      360

ttgtttttct aatccgcaga tgatcaattc aaggccgaat aagaaggctg gctctgcacc      420

ttggtgatca aataattcga tagcttgtcg taataatggc ggcatactat cagtagtagg      480

tgtttccctt tcttctttag cgacttgatg ctcttgatct tccaatacgc aacctaaagt      540

aaaatgcccc acagcgctga gtgcatataa tgcattctct agtgaaaaac cttgttggca      600

taaaaaggct aattgatttt cgagagtttc atactgtttt tctgtaggcc gtgtacctaa      660

atgtactttt gctccatcgc gatgacttag taaagcacat ctaaaacttt tagcgttatt      720

acgtaaaaaa tcttgccagc tttccccttc taaagggcaa aagtgagtat ggtgcctatc      780

taacatctca atggctaagg cgtcgagcaa agcccgctta ttttttacat gccaatacaa      840

tgtaggctgc tctacaccta gcttctgggc gagtttacgg gttgttaaac cttcgattcc      900

gacctcatta agcagctcta atgcgctgtt aatcacttta cttttatcta atctagacat      960

cattaattcc taatttttgt tgacactcta tcattgatag agttatttta ccactcccta     1020

tcagtgatag agaaaatgaa aggaggtaaa ttatgagcaa caatgccttg cagactatta     1080

ttaacgctcg tcttcccggc gaagaaggtc tgtggcaaat ccatcttcag gatggtaaga     1140

tttctgccat tgatgcccaa agcggggtga tgccaatcac ggaaaattca ctggatgcag     1200

aacagggctt ggtaattccg ccttttgtag aaccacacat ccatttggat actacccaga     1260

cggcgggtca acccaactgg aaccagagcg gtacgctttt cgaagggatc gagcgctggg     1320

ccgaacgtaa agctcttttg acacatgacg acgtaaagca acgcgcgtgg cagacactga     1380

aatggcaaat tgccaatggg attcagcatg tacgcacgca cgtggacgtt agcgacgcga     1440

ccctgaccgc attaaaggcc atgttggaag tgaagcaaga agtggcccct tggatcgatc     1500

tgcaaattgt agcttttcca caagagggta tccttagcta cccgaacgga gaagctcttt     1560

tagaggaagc gctgcgcttg ggcgctgacg ttgtcggtgc tattcctcac tttgagttta     1620

cacgcgagta tggagttgag tcgcttcata agacgttcgc tttggcccag aaatacgacc     1680

gtttaattga cgtacattgc gatgagatcg acgacgagca atcccgcttt gtagaaacag     1740

tcgccgcgtt ggcgcatcac gaaggcatgg gtgcgcgcgt aaccgcctcg cacactactg     1800

ctatgcactc gtacaacgga gcgtatacta gccgcctgtt tcgcttgctg aaaatgagtg     1860

gcattaactt tgttgccaac ccattggtca atatccattt gcaaggtcgt ttcgatacat     1920

atccaaaacg tcgtggcatc acccgtgtca aagagatgct ggagtctggc attaatgtgt     1980

gttttggaca tgacgatgta ttcgatccat ggtatccgct tggcacggct aacatgttac     2040

aagtgttgca catggggttg catgtgtgcc agttaatggg ctacggtcag atcaatgatg     2100

gcttaaactt aatcacacac cactccgcgc gcactctgaa tttgcaagac tacggcatcg     2160

cagcaggtaa ctcggccaac ctgatcatct tacccgcaga aaacggcttt gatgctttgc     2220

gccgtcaggt gccggtccgc tatagtgtgc gtggtgggaa ggttatcgcg tccacccaac     2280

cagcacagac cactgtgtac cttgaacagc ccgaagctat cgactacaaa cgctaaaagg     2340

gcgaattctg cagatatcca tcacactggc ggccgctcga gcatgcatct agagggccca     2400

attcgcccta tagtgagtcg tattacaatt cactggccgt cgttttacaa cgtcgtgact     2460

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     2520

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctatacg     2580

tacggcagtt taaggtttac acctataaaa gagagagccg ttatcgtctg tttgtggatg     2640

tacagagtga tattattgac acgccggggc gacggatggt gatccccctg gccagtgcac     2700

gtctgctgtc agataaagtc tcccgtgaac tttacccggt ggtgcatatc ggggatgaaa     2760

gctggcgcat gatgaccacc gatatggcca gtgtgccggt ctccgttatc ggggaagaag     2820

tggctgatct cagccaccgc gaaaatgaca tcaaaaacgc cattaacctg atgttctggg     2880

gaatataaat gtcaggcatg agattatcaa aaaggatctt cacctagatc cttttcacgt     2940

agaaagccag tccgcagaaa cggtgctgac cccggatgaa tgtcagctac tgggctatct     3000

ggacaaggga aaacgcaagc gcaaagagaa agcaggtagc ttgcagtggg cttacatggc     3060

gatagctaga ctgggcggtt ttatggacag caagcgaacc ggaattgcca gctggggcgc     3120

cctctggtaa ggttgggaag ccctgcaaag taaactggat ggctttctcg ccgccaagga     3180

tctgatggcg caggggatca agctctgatc aagagacagg atgaggatcg tttcgcatga     3240

ttgaacaaga tggattgcac gcaggttctc cggccgcttg ggtggagagg ctattcggct     3300

atgactgggc acaacagaca atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc     3360

aggggcgccc ggttcttttt gtcaagaccg acctgtccgg tgccctgaat gaactgcaag     3420

acgaggcagc gcggctatcg tggctggcca cgacgggcgt tccttgcgca gctgtgctcg     3480

acgttgtcac tgaagcggga agggactggc tgctattggg cgaagtgccg gggcaggatc     3540

tcctgtcatc tcaccttgct cctgccgaga aagtatccat catggctgat gcaatgcggc     3600

ggctgcatac gcttgatccg gctacctgcc cattcgacca ccaagcgaaa catcgcatcg     3660

agcgagcacg tactcggatg gaagccggtc ttgtcgatca ggatgatctg gacgaagagc     3720

atcaggggct cgcgccagcc gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg     3780

aggatctcgt cgtgacccat ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc     3840

gcttttctgg attcatcgac tgtggccggc tgggtgtggc ggaccgctat caggacatag     3900

cgttggctac ccgtgatatt gctgaagagc ttggcggcga atgggctgac cgcttcctcg     3960

tgctttacgg tatcgccgct cccgattcgc agcgcatcgc cttctatcgc cttcttgacg     4020

agttcttctg aattattaac gcttacaatt tcctgatgcg gtattttctc cttacgcatc     4080

tgtgcggtat ttcacaccgc atacaggtgg cacttttcgg ggaaatgtgc gcggaacccc     4140

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     4200

ataaatgctt caataatagc acgtgaggag ggccaccatg gccaagttga ccagtgccgt     4260

tccggtgctc accgcgcgcg acgtcgccgg agcggtcgag ttctggaccg accggctcgg     4320

gttctcccgg gacttcgtgg aggacgactt cgccggtgtg gtccgggacg acgtgaccct     4380

gttcatcagc gcggtccagg accaggtggt gccggacaac accctggcct gggtgtgggt     4440

gcgcggcctg gacgagctgt acgccgagtg gtcggaggtc gtgtccacga acttccggga     4500

cgcctccggg ccggccatga ccgagatcgg cgagcagccg tgggggcggg agttcgccct     4560

gcgcgacccg gccggcaact gcgtgcactt cgtggccgag gagcaggact gacacgtgct     4620

aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac     4680

caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa     4740

aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc     4800

accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt     4860

aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg     4920

ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc     4980

agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt     5040

accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga     5100

gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct     5160

tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg     5220

cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca     5280

cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa     5340

cgccagcaac gcggcctttt tacggttcct gggcttttgc tggccttttg ctcacatgtt     5400

ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga     5460

taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaag      5519


<210> 1213
<211> 1281
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1213
atgagcaaca atgccttgca gactattatt aacgctcgtc ttcccggcga agaaggtctg       60

tggcaaatcc atcttcagga tggtaagatt tctgccattg atgcccaaag cggggtgatg      120

ccaatcacgg aaaattcact ggatgcagaa cagggcttgg taattccgcc ttttgtagaa      180

ccacacatcc atttggatac tacccagacg gcgggtcaac ccaactggaa ccagagcggt      240

acgcttttcg aagggatcga gcgctgggcc gaacgtaaag ctcttttgac acatgacgac      300

gtaaagcaac gcgcgtggca gacactgaaa tggcaaattg ccaatgggat tcagcatgta      360

cgcacgcacg tggacgttag cgacgcgacc ctgaccgcat taaaggccat gttggaagtg      420

aagcaagaag tggccccttg gatcgatctg caaattgtag cttttccaca agagggtatc      480

cttagctacc cgaacggaga agctctttta gaggaagcgc tgcgcttggg cgctgacgtt      540

gtcggtgcta ttcctcactt tgagtttaca cgcgagtatg gagttgagtc gcttcataag      600

acgttcgctt tggcccagaa atacgaccgt ttaattgacg tacattgcga tgagatcgac      660

gacgagcaat cccgctttgt agaaacagtc gccgcgttgg cgcatcacga aggcatgggt      720

gcgcgcgtaa ccgcctcgca cactactgct atgcactcgt acaacggagc gtatactagc      780

cgcctgtttc gcttgctgaa aatgagtggc attaactttg ttgccaaccc attggtcaat      840

atccatttgc aaggtcgttt cgatacatat ccaaaacgtc gtggcatcac ccgtgtcaaa      900

gagatgctgg agtctggcat taatgtgtgt tttggacatg acgatgtatt cgatccatgg      960

tatccgcttg gcacggctaa catgttacaa gtgttgcaca tggggttgca tgtgtgccag     1020

ttaatgggct acggtcagat caatgatggc ttaaacttaa tcacacacca ctccgcgcgc     1080

actctgaatt tgcaagacta cggcatcgca gcaggtaact cggccaacct gatcatctta     1140

cccgcagaaa acggctttga tgctttgcgc cgtcaggtgc cggtccgcta tagtgtgcgt     1200

ggtgggaagg ttatcgcgtc cacccaacca gcacagacca ctgtgtacct tgaacagccc     1260

gaagctatcg actacaaacg c                                               1281


<210> 1214
<211> 4894
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1214
tagcggagtg tatactggct tactatgttg gcactgatga gggtgtcagt gaagtgcttc       60

atgtggcagg agaaaaaagg ctgcaccggt gcgtcagcag aatatgtgat acaggatata      120

ttccgcttcc tcgctcactg actcgctacg ctcggtcgtt cgactgcggc gagcggaaat      180

ggcttacgaa cggggcggag atttcctgga agatgccagg aagatactta acagggaagt      240

gagagggccg cggcaaagcc gtttttccat aggctccgcc cccctgacaa gcatcacgaa      300

atctgacgct caaatcagtg gtggcgaaac ccgacaggac tataaagata ccaggcgttt      360

cccctggcgg ctccctcgtg cgctctcctg ttcctgcctt tcggtttacc ggtgtcattc      420

cgctgttatg gccgcgtttg tctcattcca cgcctgacac tcagttccgg gtaggcagtt      480

cgctccaagc tggactgtat gcacgaaccc cccgttcagt ccgaccgctg cgccttatcc      540

ggtaactatc gtcttgagtc caacccggaa agacatgcaa aagcaccact ggcagcagcc      600

actggtaatt gatttagagg agttagtctt gaagtcatgc gccggttaag gctaaactga      660

aaggacaagt tttggtgact gcgctcctcc aagccagtta cctcggttca aagagttggt      720

agctcagaga accttcgaaa aaccgccctg caaggcggtt ttttcgtttt cagagcaaga      780

gattacgcgc agaccaaaac gatctcaaga agatcatctt attaaggggt ctgacgctca      840

gtggaacggt gcaccctgca gggctagctg ataaagcgtt cgcgctgcat tcggcagttt      900

aagacccact ttcacattta agttgttttt ctaatccgca tatgatcaat tcaaggccga      960

ataagaaggc tggctctgca ccttggtgat caaataattc gatagcttgt cgtaataatg     1020

gcggcatact atcagtagta ggtgtttccc tttcttcttt agcgacttga tgctcttgat     1080

cttccaatac gcaacctaaa gtaaaatgcc ccacagcgct gagtgcatat aatgcattct     1140

ctagtgaaaa accttgttgg cataaaaagg ctaattgatt ttcgagagtt tcatactgtt     1200

tttctgtagg ccgtgtacct aaatgtactt ttgctccatc gcgatgactt agtaaagcac     1260

atctaaaact tttagcgtta ttacgtaaaa aatcttgcca gctttcccct tctaaagggc     1320

aaaagtgagt atggtgccta tctaacatct caatggctaa ggcgtcgagc aaagcccgct     1380

tattttttac atgccaatac aatgtaggct gctctacacc tagcttctgg gcgagtttac     1440

gggttgttaa accttcgatt ccgacctcat taagcagctc taatgcgctg ttaatcactt     1500

tacttttatc taatctagac atcattaatt cctaattttt gttgacactc tatcattgat     1560

agagttattt taccactccc tatcagtgat agagaaaagt gaacttcact tattagggag     1620

gaaagaatat gtcaaataac gctctgcaga ctattataaa tgctcgattg ccaggggaag     1680

aggggttgtg gcaaattcac cttcaggatg ggaagatctc tgcgatagat gcgcagtcgg     1740

gcgtgatgcc aatcactgaa aactctctcg acgcggaaca gggcctggtt attcctccgt     1800

ttgttgagcc acacattcac cttgatacta cgcagacggc aggtcagccc aattggaatc     1860

agtctggtac cttgtttgag gggatagagc ggtgggccga acgtaaggca ttgctgaccc     1920

acgatgatgt caaacagcgc gcttggcaga ctttaaagtg gcaaattgcg aatggcatcc     1980

agcatgttag aacacacgtg gatgtgtcgg atgctactct gacggctctg aaagcgatgc     2040

ttgaagttaa gcaggaggtt gccccgtgga tcgatctgca aattgttgca ttcccgcagg     2100

agggcatcct cagctatccg aacggtgagg cgcttctcga agaagctctc agacttggag     2160

cggacgttgt gggcgcgatc ccgcatttcg aattcactcg cgagtacggt gtggaatcac     2220

ttcacaaaac ctttgcgctg gcacagaagt atgaccgact tattgatgta cattgcgatg     2280

aaatagatga tgagcagtcc agattcgttg aaaccgttgc agcgttggct catcacgagg     2340

gcatgggcgc acgcgtcact gcctcccaca cgaccgcgat gcattcgtat aacggtgcat     2400

acacctcacg cctgtttcgg ctgttaaaaa tgagcggaat aaacttcgtc gctaatccat     2460

tggttaatat tcatttgcag ggtcgctttg atacgtatcc aaaaagacgc ggcataacgc     2520

gagtcaaaga aatgctggag agtggtatca atgtgtgctt tggccacgat gatgttttcg     2580

atccctggta tccgcttgga acggcgaata tgcttcaggt tctgcacatg gggctgcacg     2640

tgtgccagct gatgggttac ggacaaatta acgatggcct gaatctcatc acccatcatt     2700

ctgcccgaac tcttaacctg caggattatg gaattgcggc gggcaattct gctaatctga     2760

taatactgcc tgctgaaaac ggtttcgacg cgctccgccg acaagtgccc gttcgttaca     2820

gtgttcgagg cggcaaagtc atcgcgtcaa ctcaaccagc tcaaactact gtatatctgg     2880

aacagcccga agctattgac tacaaacgag gctcagatta taaggacgat gatgataaag     2940

gtagcaaaat agttgaagtt aaacatcccc tcgttaaaca caaactgggc ttgatgcgcg     3000

aacaggacat atcgaccaaa cgcttccgtg aactggcttc agaagtgggc tcactactga     3060

cgtatgaagc aaccgcagat cttgagacag aaaaagtaac tattgaaggc tggaatggcc     3120

ccgtagagat agatcagatc aaaggtaaaa aaattacggt cgttccgatt ttgcgcgccg     3180

ggctgggcat gatggatgga gtgttagaaa acgtcccatc cgcccggatc tcggtggtcg     3240

gaatgtaccg caacgaagag acgcttgaac cagtccctta cttccagaag ttggttagta     3300

acatagacga acgaatggcc ttaatagtag atccgatgct cgcgactggc ggcagcgtga     3360

tcgctacgat tgatctgttg aaaaaagcgg ggtgtagttc tatcaaagtt ctggttctcg     3420

tcgcggcgcc agaaggtatt gccgcgttag aaaaagcaca tccggacgtc gaactgtaca     3480

ctgcatctat tgaccaggga ttgaacgagc atggatatat aattccgggc ttgggcgatg     3540

cgggagataa aatcttcggt actaagtaag gaggaacgat tggtaaaccc ggtgaacgca     3600

tgagaaagcc cccggaagat caccttccgg gggctttttt attgcgcgga ccaaaacgaa     3660

aaaagacgct cgaaagcgtc tcttttctgg aatttggtac cgaggcgtaa tgctctgcca     3720

gtgttacaac caattaacca attctgatta gaaaaactca tcgagcatca aatgaaactg     3780

caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt tctgtaatga     3840

aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc ggtctgcgat     3900

tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa taaggttatc     3960

aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa gcttatgcat     4020

ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat cactcgcatc     4080

aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc gatcgctgtt     4140

aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg ccagcgcatc     4200

aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg ttttcccggg     4260

gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct tgatggtcgg     4320

aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa catcattggc     4380

aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc catacaatcg     4440

atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc catataaatc     4500

agcatccatg ttggaattta atcgcggcct cgagcaagac gtttcccgtt gaatatggct     4560

cataacaccc cttgtattac tgtttatgta agcagacagt tttattgttc atgatgatat     4620

atttttatct tgtgcaatgt aacatcagag attttgagac acaacgtggc tttgttgaat     4680

aaatcgaact tttgctgagt tgaaggatca gatcacgcat cttcccgaca acgcagaccg     4740

ttccgtggca aagcaaaagt tcaaaatcac caactggtcc acctacaaca aagctctcat     4800

caaccgtggc tccctcactt tctggctgga tgatggggcg attcaggcct ggtatgagtc     4860

agcaacacct tcttcacgag gcagacctca gcgc                                 4894


<210> 1215
<211> 1941
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1215
atgtcaaata acgctctgca gactattata aatgctcgat tgccagggga agaggggttg       60

tggcaaattc accttcagga tgggaagatc tctgcgatag atgcgcagtc gggcgtgatg      120

ccaatcactg aaaactctct cgacgcggaa cagggcctgg ttattcctcc gtttgttgag      180

ccacacattc accttgatac tacgcagacg gcaggtcagc ccaattggaa tcagtctggt      240

accttgtttg aggggataga gcggtgggcc gaacgtaagg cattgctgac ccacgatgat      300

gtcaaacagc gcgcttggca gactttaaag tggcaaattg cgaatggcat ccagcatgtt      360

agaacacacg tggatgtgtc ggatgctact ctgacggctc tgaaagcgat gcttgaagtt      420

aagcaggagg ttgccccgtg gatcgatctg caaattgttg cattcccgca ggagggcatc      480

ctcagctatc cgaacggtga ggcgcttctc gaagaagctc tcagacttgg agcggacgtt      540

gtgggcgcga tcccgcattt cgaattcact cgcgagtacg gtgtggaatc acttcacaaa      600

acctttgcgc tggcacagaa gtatgaccga cttattgatg tacattgcga tgaaatagat      660

gatgagcagt ccagattcgt tgaaaccgtt gcagcgttgg ctcatcacga gggcatgggc      720

gcacgcgtca ctgcctccca cacgaccgcg atgcattcgt ataacggtgc atacacctca      780

cgcctgtttc ggctgttaaa aatgagcgga ataaacttcg tcgctaatcc attggttaat      840

attcatttgc agggtcgctt tgatacgtat ccaaaaagac gcggcataac gcgagtcaaa      900

gaaatgctgg agagtggtat caatgtgtgc tttggccacg atgatgtttt cgatccctgg      960

tatccgcttg gaacggcgaa tatgcttcag gttctgcaca tggggctgca cgtgtgccag     1020

ctgatgggtt acggacaaat taacgatggc ctgaatctca tcacccatca ttctgcccga     1080

actcttaacc tgcaggatta tggaattgcg gcgggcaatt ctgctaatct gataatactg     1140

cctgctgaaa acggtttcga cgcgctccgc cgacaagtgc ccgttcgtta cagtgttcga     1200

ggcggcaaag tcatcgcgtc aactcaacca gctcaaacta ctgtatatct ggaacagccc     1260

gaagctattg actacaaacg aggctcagat tataaggacg atgatgataa aggtagcaaa     1320

atagttgaag ttaaacatcc cctcgttaaa cacaaactgg gcttgatgcg cgaacaggac     1380

atatcgacca aacgcttccg tgaactggct tcagaagtgg gctcactact gacgtatgaa     1440

gcaaccgcag atcttgagac agaaaaagta actattgaag gctggaatgg ccccgtagag     1500

atagatcaga tcaaaggtaa aaaaattacg gtcgttccga ttttgcgcgc cgggctgggc     1560

atgatggatg gagtgttaga aaacgtccca tccgcccgga tctcggtggt cggaatgtac     1620

cgcaacgaag agacgcttga accagtccct tacttccaga agttggttag taacatagac     1680

gaacgaatgg ccttaatagt agatccgatg ctcgcgactg gcggcagcgt gatcgctacg     1740

attgatctgt tgaaaaaagc ggggtgtagt tctatcaaag ttctggttct cgtcgcggcg     1800

ccagaaggta ttgccgcgtt agaaaaagca catccggacg tcgaactgta cactgcatct     1860

attgaccagg gattgaacga gcatggatat ataattccgg gcttgggcga tgcgggagat     1920

aaaatcttcg gtactaagta a                                               1941


<210> 1216
<211> 427
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1216
Met Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn Ala Arg Leu Pro Gly 
1               5                   10                  15      


Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser Ala 
            20                  25                  30          


Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile His 
    50                  55                  60                  


Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser Gly 
65                  70                  75                  80  


Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu Leu 
                85                  90                  95      


Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp Gln 
            100                 105                 110         


Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser Asp 
        115                 120                 125             


Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu Val 
    130                 135                 140                 


Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly Ile 
145                 150                 155                 160 


Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg Leu 
                165                 170                 175     


Gly Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg Glu 
            180                 185                 190         


Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys Tyr 
        195                 200                 205             


Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln Ser 
    210                 215                 220                 


Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met Gly 
225                 230                 235                 240 


Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn Gly 
                245                 250                 255     


Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile Asn 
            260                 265                 270         


Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe Asp 
        275                 280                 285             


Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu Glu 
    290                 295                 300                 


Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro Trp 
305                 310                 315                 320 


Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly Leu 
                325                 330                 335     


His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu Asn 
            340                 345                 350         


Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr Gly 
        355                 360                 365             


Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu Asn 
    370                 375                 380                 


Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val Arg 
385                 390                 395                 400 


Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val Tyr 
                405                 410                 415     


Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425         


<210> 1217
<211> 646
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1217
Met Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn Ala Arg Leu Pro Gly 
1               5                   10                  15      


Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser Ala 
            20                  25                  30          


Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile His 
    50                  55                  60                  


Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser Gly 
65                  70                  75                  80  


Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu Leu 
                85                  90                  95      


Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp Gln 
            100                 105                 110         


Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser Asp 
        115                 120                 125             


Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu Val 
    130                 135                 140                 


Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly Ile 
145                 150                 155                 160 


Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg Leu 
                165                 170                 175     


Gly Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg Glu 
            180                 185                 190         


Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys Tyr 
        195                 200                 205             


Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln Ser 
    210                 215                 220                 


Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met Gly 
225                 230                 235                 240 


Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn Gly 
                245                 250                 255     


Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile Asn 
            260                 265                 270         


Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe Asp 
        275                 280                 285             


Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu Glu 
    290                 295                 300                 


Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro Trp 
305                 310                 315                 320 


Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly Leu 
                325                 330                 335     


His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu Asn 
            340                 345                 350         


Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr Gly 
        355                 360                 365             


Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu Asn 
    370                 375                 380                 


Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val Arg 
385                 390                 395                 400 


Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val Tyr 
                405                 410                 415     


Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg Gly Ser Asp Tyr Lys 
            420                 425                 430         


Asp Asp Asp Asp Lys Gly Ser Lys Ile Val Glu Val Lys His Pro Leu 
        435                 440                 445             


Val Lys His Lys Leu Gly Leu Met Arg Glu Gln Asp Ile Ser Thr Lys 
    450                 455                 460                 


Arg Phe Arg Glu Leu Ala Ser Glu Val Gly Ser Leu Leu Thr Tyr Glu 
465                 470                 475                 480 


Ala Thr Ala Asp Leu Glu Thr Glu Lys Val Thr Ile Glu Gly Trp Asn 
                485                 490                 495     


Gly Pro Val Glu Ile Asp Gln Ile Lys Gly Lys Lys Ile Thr Val Val 
            500                 505                 510         


Pro Ile Leu Arg Ala Gly Leu Gly Met Met Asp Gly Val Leu Glu Asn 
        515                 520                 525             


Val Pro Ser Ala Arg Ile Ser Val Val Gly Met Tyr Arg Asn Glu Glu 
    530                 535                 540                 


Thr Leu Glu Pro Val Pro Tyr Phe Gln Lys Leu Val Ser Asn Ile Asp 
545                 550                 555                 560 


Glu Arg Met Ala Leu Ile Val Asp Pro Met Leu Ala Thr Gly Gly Ser 
                565                 570                 575     


Val Ile Ala Thr Ile Asp Leu Leu Lys Lys Ala Gly Cys Ser Ser Ile 
            580                 585                 590         


Lys Val Leu Val Leu Val Ala Ala Pro Glu Gly Ile Ala Ala Leu Glu 
        595                 600                 605             


Lys Ala His Pro Asp Val Glu Leu Tyr Thr Ala Ser Ile Asp Gln Gly 
    610                 615                 620                 


Leu Asn Glu His Gly Tyr Ile Ile Pro Gly Leu Gly Asp Ala Gly Asp 
625                 630                 635                 640 


Lys Ile Phe Gly Thr Lys 
                645     


<210> 1218
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1218
Met Lys Arg His Leu Asn Thr Ser Tyr Arg Leu Val Trp Asn His Ile 
1               5                   10                  15      


Thr Gly Ala Phe Val Val Ala Ser Glu Leu Ala Arg Ala Arg Gly Lys 
            20                  25                  30          


Arg Ala Gly Val Ala Val Ala Leu Ser Leu Ala Ala Ala Thr Ser Leu 
        35                  40                  45              


Pro Ala Leu Ala 
    50          


<210> 1219
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1219
Met Asn Lys Ile Phe Lys Val Ile Trp Asn Pro Ala Thr Gly Ser Tyr 
1               5                   10                  15      


Thr Val Ala Ser Glu Thr Ala Lys Ser Arg Gly Lys Lys Ser Gly Arg 
            20                  25                  30          


Ser Lys Leu Leu Ile Ser Ala Leu Val Ala Gly Gly Leu Leu Ser Ser 
        35                  40                  45              


Phe Gly Ala Ser Ala 
    50              


<210> 1220
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1220
Met Gln Leu Arg Lys Pro Ala Thr Ala Ile Leu Ala Leu Ala Leu Ser 
1               5                   10                  15      


Ala Gly Leu Ala Gln Ala 
            20          


<210> 1221
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1221
Met Phe Trp Arg Asp Met Thr Leu Ser Val Trp Arg Lys Lys Thr Thr 
1               5                   10                  15      


Gly Leu Lys Thr Lys Lys Arg Leu Leu Ala Leu Val Leu Ala Ala Ala 
            20                  25                  30          


Leu Cys Ser Ser Pro Val Trp Ala 
        35                  40  


<210> 1222
<211> 159
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1222
atgaacaaga ttttcaaggt tatctggaac cccgcgacag gcagctacac tgtggcctcc       60

gaaaccgcta agtcgcgcgg caagaagtca ggacgttcaa agctgcttat ttctgcttta      120

gtagccggag gattactttc tagctttgga gcctcggca                             159


<210> 1223
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1223
atgaaaaaaa tctggctggc attagcaggc ttagtcctgg cctttagtgc ctcggca          57


<210> 1224
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1224
atgcagttgc gcaagcctgc cacggcaatt ttagcattag ctctttctgc gggcttggcc       60

caggca                                                                  66


<210> 1225
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1225
atgttctggc gcgacatgac actgagcgtt tggcgtaaaa aaacaacggg actgaaaacc       60

aaaaagcgtt tgttagccct tgtcctggcg gcagccctgt gctcgtcccc ggtatgggca      120


<210> 1226
<211> 99
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1226
atgggataca agatgaacat ttcatcactt cgcaaagctt ttatcttcat gggtgccgtt       60

gctgctctgt cactggtcaa tgctcaatcg gccctggca                              99


<210> 1227
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1227
atgaagatta aaacaggcgc tcgtattttg gccctgtctg cgcttacgac tatgatgttt       60

agtgcctcgg ccctggca                                                     78


<210> 1228
<211> 78
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1228
atgacgaata tcactaaacg tagccttgtg gccgcggggg tcttggctgc attgatggct       60

ggcaatgttg ctctggca                                                     78


<210> 1229
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1229
atgaaatatc tgttgcccac ggctgccgcg ggtctgctgc tgctggcagc gcaaccggct       60

atggca                                                                  66


<210> 1230
<211> 63
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1230
atgaagcaaa gtacgatcgc ccttgcgctg ttgccccttc ttttcacgcc cgtcaccaag       60

gca                                                                     63


<210> 1231
<211> 343
<212> PRT
<213> Homo sapiens

<400> 1231
Glu Glu Glu Leu Gln Val Ile Gln Pro Asp Lys Ser Val Leu Val Ala 
1               5                   10                  15      


Ala Gly Glu Thr Ala Thr Leu Arg Cys Thr Ala Thr Ser Leu Ile Pro 
            20                  25                  30          


Val Gly Pro Ile Gln Trp Phe Arg Gly Ala Gly Pro Gly Arg Glu Leu 
        35                  40                  45              


Ile Tyr Asn Gln Lys Glu Gly His Phe Pro Arg Val Thr Thr Val Ser 
    50                  55                  60                  


Asp Leu Thr Lys Arg Asn Asn Met Asp Phe Ser Ile Arg Ile Gly Asn 
65                  70                  75                  80  


Ile Thr Pro Ala Asp Ala Gly Thr Tyr Tyr Cys Val Lys Phe Arg Lys 
                85                  90                  95      


Gly Ser Pro Asp Asp Val Glu Phe Lys Ser Gly Ala Gly Thr Glu Leu 
            100                 105                 110         


Ser Val Arg Ala Lys Pro Ser Ala Pro Val Val Ser Gly Pro Ala Ala 
        115                 120                 125             


Arg Ala Thr Pro Gln His Thr Val Ser Phe Thr Cys Glu Ser His Gly 
    130                 135                 140                 


Phe Ser Pro Arg Asp Ile Thr Leu Lys Trp Phe Lys Asn Gly Asn Glu 
145                 150                 155                 160 


Leu Ser Asp Phe Gln Thr Asn Val Asp Pro Val Gly Glu Ser Val Ser 
                165                 170                 175     


Tyr Ser Ile His Ser Thr Ala Lys Val Val Leu Thr Arg Glu Asp Val 
            180                 185                 190         


His Ser Gln Val Ile Cys Glu Val Ala His Val Thr Leu Gln Gly Asp 
        195                 200                 205             


Pro Leu Arg Gly Thr Ala Asn Leu Ser Glu Thr Ile Arg Val Pro Pro 
    210                 215                 220                 


Thr Leu Glu Val Thr Gln Gln Pro Val Arg Ala Glu Asn Gln Val Asn 
225                 230                 235                 240 


Val Thr Cys Gln Val Arg Lys Phe Tyr Pro Gln Arg Leu Gln Leu Thr 
                245                 250                 255     


Trp Leu Glu Asn Gly Asn Val Ser Arg Thr Glu Thr Ala Ser Thr Val 
            260                 265                 270         


Thr Glu Asn Lys Asp Gly Thr Tyr Asn Trp Met Ser Trp Leu Leu Val 
        275                 280                 285             


Asn Val Ser Ala His Arg Asp Asp Val Lys Leu Thr Cys Gln Val Glu 
    290                 295                 300                 


His Asp Gly Gln Pro Ala Val Ser Lys Ser His Asp Leu Lys Val Ser 
305                 310                 315                 320 


Ala His Pro Lys Glu Gln Gly Ser Asn Thr Ala Ala Glu Asn Thr Gly 
                325                 330                 335     


Ser Asn Glu Arg Asn Ile Tyr 
            340             


<210> 1232
<211> 342
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1232
aactgggtga atgtcatctc ggacttaaag aagattgaag acttgattca gagcatgcat       60

atcgacgcga ctttatacac cgagtctgac gtacacccaa gttgcaaggt caccgccatg      120

aagtgcttct tgcttgagtt acaagtcatc agtttggaat ctggagacgc tagtattcac      180

gatacggtgg aaaacctgat catccttgca aatgactctc tttcatccaa tggtaatgtt      240

actgagtcgg ggtgcaaaga atgtgaagaa cttgaggaga agaacattaa ggaatttctt      300

cagtcattcg tgcatatcgt acagatgttc atcaacacct ct                         342


<210> 1233
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1233
tccggaggga gcggcggcgg gggtagtgga ggcgggtcag gcggcggggg ctcacttcag       60


<210> 1234
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1234
gattataaag acgatgacga taagatcgaa ggacgt                                 36


<210> 1235
<211> 1791
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1235
atggggtaca aaatgaacat tagctcgctt cgcaaagcat tcatttttat gggggctgtt       60

gcagctttaa gccttgtcaa tgcccagtca gcgcttgccg tcgactataa ggatgacgac      120

gacaagcaat tgggcggtgg catctgggag cttaagaagg acgtgtatgt agtggagtta      180

gactggtatc cagatgcccc cggagagatg gtggtcttaa catgtgacac tccagaggag      240

gacgggatta cctggacact tgaccagtca agcgaggtat tgggttctgg aaagacgctt      300

actattcaag tcaaagaatt tggggatgcc gggcagtata catgtcacaa gggcggcgaa      360

gttctgtcgc actccttact tttgttacac aaaaaagaag acggcatttg gtccacagac      420

atccttaagg accaaaagga gccgaagaat aagacgtttc tgcgctgtga agcgaagaac      480

tatagtggtc gctttacttg ctggtggttg acgaccattt ccactgattt aaccttttcg      540

gtaaagagtt ctcgcgggag ttccgaccca cagggcgtga cttgtggcgc agccacactt      600

tcggcggaac gcgttcgtgg ggacaataag gaatacgaat attcggtcga gtgtcaggaa      660

gattcagctt gccctgccgc tgaggagtca cttccgattg aagtgatggt tgacgccgtg      720

cacaaattaa agtatgaaaa ttacacgtca tctttcttta tccgtgacat tattaagccc      780

gacccgccaa agaatctgca gcttaaaccc ctgaagaaca gccgccaggt ggaagtaagc      840

tgggaatatc ctgacacctg gtccactccg cattcgtatt tctcgttgac gttttgtgtt      900

caggtgcagg gaaagagcaa gcgcgaaaag aaggatcgcg tctttacaga caaaacgtcc      960

gcgacggtta tttgtcgtaa gaatgctagt atctctgttc gcgctcagga ccgttattac     1020

tcatctagtt ggtcggagtg ggcctcggtt ccctgctctg ggggtggagg atcgggtgga     1080

ggtggctcgg gaggtggcgg ctcccgtaat ttaccggtgg ctactcctga cccagggatg     1140

ttcccgtgct tgcaccatag ccaaaactta cttcgcgctg tcagcaacat gcttcagaaa     1200

gcacgtcaaa cgcttgagtt ttacccgtgt actagcgaag agatcgatca cgaggacatt     1260

accaaagaca aaacctccac cgtcgaggcc tgccttccac ttgaactgac gaaaaatgag     1320

tcatgcttaa attctcgtga aacctccttc attactaacg gatcgtgcct ggcctcgcgc     1380

aagacttcgt tcatgatggc attatgcttg tcgtctattt atgaagacct taaaatgtat     1440

caagtggagt tcaagacgat gaatgcaaaa cttcttatgg acccgaagcg tcaaatcttc     1500

ttagaccaaa acatgttggc cgtgatcgat gaactgatgc aagccttgaa ttttaattcg     1560

gaaactgtac cgcaaaaatc ttctcttgaa gaaccggatt tctataagac caaaattaaa     1620

ctttgtattt tacttcacgc tttccgcatc cgtgcagtaa ctatcgaccg cgtaatgagt     1680

taccttaacg cctcgggtgg cgagctcggt ggcagtggta agcctatccc taaccctctc     1740

ctcggcctcg attctacggg atccggtcat caccaccatc accatcacca t              1791


<210> 1236
<211> 69
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1236
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu 
65                  


<210> 1237
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1237
atgtttaagt ctacacttgc agccatggcc gcagtcttcg cactgtcagc cttgagtcct       60

gctgcaatgg ca                                                           72


<210> 1238
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1238
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210> 1239
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1239
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210> 1240
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1240
Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210> 1241
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1241
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210> 1242
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(30) 
<223> This sequence may encompass 1-6 'Gly Gly Gly Gly Ser'
      repeating units

<400> 1242
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 1243
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1243
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 1244
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1244
Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210> 1245
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1245
Gly Gly Gly Gly Ser 
1               5   


<210> 1246
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (17)..(17)
<223> a, c, t, g, unknown or other

<400> 1246
wntgaatwww wattcanw                                                     18


<210> 1247
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1247
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 1248
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6) 
<223> 1,3 dimethyl-His

<400> 1248
Cys Ala Val Ala Tyr His 
1               5       


<210> 1249
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1249
ttgttgayry rtcaacwa                                                     18


<210> 1250
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1250
ggaaaatttt tttaaaaaaa aaac                                              24


<210> 1251
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1251
Ala Gly Tyr Gly Ser Thr Leu Thr 
1               5               


<210> 1252
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 1252
His His His His His His 
1               5       


<210> 1253
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1253
atgaagaaaa tttggctggc acttgccggt ttggtattag cgttttccgc ctcggca          57
