                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Li, Yulin
       Felsher, Dean
       Deutzmann, Anja
 
<120>  TARGET GENES IN MYC-DRIVEN NEOPLASIA

<130>  STAN-1359WO

<150>  US 62/442,260
<151>  2017-01-04

<160>  259   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic polynucleotide sequence

<400>  1
gcgtgcagtt tagggcatcg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic polynucleotide sequence

<400>  2
ggccagaaat gatccggact                                                   20


<210>  3
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Ser Thr Leu Thr Ala Ser Glu Ile Arg Gln Arg Phe Ile Asp 
1               5                   10                  15      


Phe Phe Lys Arg Asn Glu His Thr Tyr Val His Ser Ser Ala Thr Ile 
            20                  25                  30          


Pro Leu Asp Asp Pro Thr Leu Leu Phe Ala Asn Ala Gly Met Asn Gln 
        35                  40                  45              


Phe Lys Pro Ile Phe Leu Asn Thr Ile Asp Pro Ser His Pro Met Ala 
    50                  55                  60                  


Lys Leu Ser Arg Ala Ala Asn Thr Gln Lys Cys Ile Arg Ala Gly Gly 
65                  70                  75                  80  


Lys His Asn Asp Leu Asp Asp Val Gly Lys Asp Val Tyr His His Thr 
                85                  90                  95      


Phe Phe Glu Met Leu Gly Ser Trp Ser Phe Gly Asp Tyr Phe Lys Glu 
            100                 105                 110         


Leu Ala Cys Lys Met Ala Leu Glu Leu Leu Thr Gln Glu Phe Gly Ile 
        115                 120                 125             


Pro Ile Glu Arg Leu Tyr Val Thr Tyr Phe Gly Gly Asp Glu Ala Ala 
    130                 135                 140                 


Gly Leu Glu Ala Asp Leu Glu Cys Lys Gln Ile Trp Gln Asn Leu Gly 
145                 150                 155                 160 


Leu Asp Asp Thr Lys Ile Leu Pro Gly Asn Met Lys Asp Asn Phe Trp 
                165                 170                 175     


Glu Met Gly Asp Thr Gly Pro Cys Gly Pro Cys Ser Glu Ile His Tyr 
            180                 185                 190         


Asp Arg Ile Gly Gly Arg Asp Ala Ala His Leu Val Asn Gln Asp Asp 
        195                 200                 205             


Pro Asn Val Leu Glu Ile Trp Asn Leu Val Phe Ile Gln Tyr Asn Arg 
    210                 215                 220                 


Glu Ala Asp Gly Ile Leu Lys Pro Leu Pro Lys Lys Ser Ile Asp Thr 
225                 230                 235                 240 


Gly Met Gly Leu Glu Arg Leu Val Ser Val Leu Gln Asn Lys Met Ser 
                245                 250                 255     


Asn Tyr Asp Thr Asp Leu Phe Val Pro Tyr Phe Glu Ala Ile Gln Lys 
            260                 265                 270         


Gly Thr Gly Ala Arg Pro Tyr Thr Gly Lys Val Gly Ala Glu Asp Ala 
        275                 280                 285             


Asp Gly Ile Asp Met Ala Tyr Arg Val Leu Ala Asp His Ala Arg Thr 
    290                 295                 300                 


Ile Thr Val Ala Leu Ala Asp Gly Gly Arg Pro Asp Asn Thr Gly Arg 
305                 310                 315                 320 


Gly Tyr Val Leu Arg Arg Ile Leu Arg Arg Ala Val Arg Tyr Ala His 
                325                 330                 335     


Glu Lys Leu Asn Ala Ser Arg Gly Phe Phe Ala Thr Leu Val Asp Val 
            340                 345                 350         


Val Val Gln Ser Leu Gly Asp Ala Phe Pro Glu Leu Lys Lys Asp Pro 
        355                 360                 365             


Asp Met Val Lys Asp Ile Ile Asn Glu Glu Glu Val Gln Phe Leu Lys 
    370                 375                 380                 


Thr Leu Ser Arg Gly Arg Arg Ile Leu Asp Arg Lys Ile Gln Ser Leu 
385                 390                 395                 400 


Gly Asp Ser Lys Thr Ile Pro Gly Asp Thr Ala Trp Leu Leu Tyr Asp 
                405                 410                 415     


Thr Tyr Gly Phe Pro Val Asp Leu Thr Gly Leu Ile Ala Glu Glu Lys 
            420                 425                 430         


Gly Leu Val Val Asp Met Asp Gly Phe Glu Glu Glu Arg Lys Leu Ala 
        435                 440                 445             


Gln Leu Lys Ser Gln Gly Lys Gly Ala Gly Gly Glu Asp Leu Ile Met 
    450                 455                 460                 


Leu Asp Ile Tyr Ala Ile Glu Glu Leu Arg Ala Arg Gly Leu Glu Val 
465                 470                 475                 480 


Thr Asp Asp Ser Pro Lys Tyr Asn Tyr His Leu Asp Ser Ser Gly Ser 
                485                 490                 495     


Tyr Val Phe Glu Asn Thr Val Ala Thr Val Met Ala Leu Arg Arg Glu 
            500                 505                 510         


Lys Met Phe Val Glu Glu Val Ser Thr Gly Gln Glu Cys Gly Val Val 
        515                 520                 525             


Leu Asp Lys Thr Cys Phe Tyr Ala Glu Gln Gly Gly Gln Ile Tyr Asp 
    530                 535                 540                 


Glu Gly Tyr Leu Val Lys Val Asp Asp Ser Ser Glu Asp Lys Thr Glu 
545                 550                 555                 560 


Phe Thr Val Lys Asn Ala Gln Val Arg Gly Gly Tyr Val Leu His Ile 
                565                 570                 575     


Gly Thr Ile Tyr Gly Asp Leu Lys Val Gly Asp Gln Val Trp Leu Phe 
            580                 585                 590         


Ile Asp Glu Pro Arg Arg Arg Pro Ile Met Ser Asn His Thr Ala Thr 
        595                 600                 605             


His Ile Leu Asn Phe Ala Leu Arg Ser Val Leu Gly Glu Ala Asp Gln 
    610                 615                 620                 


Lys Gly Ser Leu Val Ala Pro Asp Arg Leu Arg Phe Asp Phe Thr Ala 
625                 630                 635                 640 


Lys Gly Ala Met Ser Thr Gln Gln Ile Lys Lys Ala Glu Glu Ile Ala 
                645                 650                 655     


Asn Glu Met Ile Glu Ala Ala Lys Ala Val Tyr Thr Gln Asp Cys Pro 
            660                 665                 670         


Leu Ala Ala Ala Lys Ala Ile Gln Gly Leu Arg Ala Val Phe Asp Glu 
        675                 680                 685             


Thr Tyr Pro Asp Pro Val Arg Val Val Ser Ile Gly Val Pro Val Ser 
    690                 695                 700                 


Glu Leu Leu Asp Asp Pro Ser Gly Pro Ala Gly Ser Leu Thr Ser Val 
705                 710                 715                 720 


Glu Phe Cys Gly Gly Thr His Leu Arg Asn Ser Ser His Ala Gly Ala 
                725                 730                 735     


Phe Val Ile Val Thr Glu Glu Ala Ile Ala Lys Gly Ile Arg Arg Ile 
            740                 745                 750         


Val Ala Val Thr Gly Ala Glu Ala Gln Lys Ala Leu Arg Lys Ala Glu 
        755                 760                 765             


Ser Leu Lys Lys Cys Leu Ser Val Met Glu Ala Lys Val Lys Ala Gln 
    770                 775                 780                 


Thr Ala Pro Asn Lys Asp Val Gln Arg Glu Ile Ala Asp Leu Gly Glu 
785                 790                 795                 800 


Ala Leu Ala Thr Ala Val Ile Pro Gln Trp Gln Lys Asp Glu Leu Arg 
                805                 810                 815     


Glu Thr Leu Lys Ser Leu Lys Lys Val Met Asp Asp Leu Asp Arg Ala 
            820                 825                 830         


Ser Lys Ala Asp Val Gln Lys Arg Val Leu Glu Lys Thr Lys Gln Phe 
        835                 840                 845             


Ile Asp Ser Asn Pro Asn Gln Pro Leu Val Ile Leu Glu Met Glu Ser 
    850                 855                 860                 


Gly Ala Ser Ala Lys Ala Leu Asn Glu Ala Leu Lys Leu Phe Lys Met 
865                 870                 875                 880 


His Ser Pro Gln Thr Ser Ala Met Leu Phe Thr Val Asp Asn Glu Ala 
                885                 890                 895     


Gly Lys Ile Thr Cys Leu Cys Gln Val Pro Gln Asn Ala Ala Asn Arg 
            900                 905                 910         


Gly Leu Lys Ala Ser Glu Trp Val Gln Gln Val Ser Gly Leu Met Asp 
        915                 920                 925             


Gly Lys Gly Gly Gly Lys Asp Val Ser Ala Gln Ala Thr Gly Lys Asn 
    930                 935                 940                 


Val Gly Cys Leu Gln Glu Ala Leu Gln Leu Ala Thr Ser Phe Ala Gln 
945                 950                 955                 960 


Leu Arg Leu Gly Asp Val Lys Asn 
                965             


<210>  4
<211>  985
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ser Val Ala Ala Ala Ala Arg Arg Leu Arg Arg Ala Ile 
1               5                   10                  15      


Arg Arg Ser Pro Ala Trp Arg Gly Leu Ser His Arg Pro Leu Ser Ser 
            20                  25                  30          


Glu Pro Pro Ala Ala Lys Ala Ser Ala Val Arg Ala Ala Phe Leu Asn 
        35                  40                  45              


Phe Phe Arg Asp Arg His Gly His Arg Leu Val Pro Ser Ala Ser Val 
    50                  55                  60                  


Arg Pro Arg Gly Asp Pro Ser Leu Leu Phe Val Asn Ala Gly Met Asn 
65                  70                  75                  80  


Gln Phe Lys Pro Ile Phe Leu Gly Thr Val Asp Pro Arg Ser Glu Met 
                85                  90                  95      


Ala Gly Phe Arg Arg Val Ala Asn Ser Gln Lys Cys Val Arg Ala Gly 
            100                 105                 110         


Gly His His Asn Asp Leu Glu Asp Val Gly Arg Asp Leu Ser His His 
        115                 120                 125             


Thr Phe Phe Glu Met Leu Gly Asn Trp Ala Phe Gly Gly Glu Tyr Phe 
    130                 135                 140                 


Lys Glu Glu Ala Cys Asn Met Ala Trp Glu Leu Leu Thr Gln Val Tyr 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Arg Leu Trp Ile Ser Tyr Phe Asp Gly Asp Pro 
                165                 170                 175     


Lys Ala Gly Leu Asp Pro Asp Leu Glu Thr Arg Asp Ile Trp Leu Ser 
            180                 185                 190         


Leu Gly Val Pro Ala Ser Arg Val Leu Ser Phe Gly Pro Gln Glu Asn 
        195                 200                 205             


Phe Trp Glu Met Gly Asp Thr Gly Pro Cys Gly Pro Cys Thr Glu Ile 
    210                 215                 220                 


His Tyr Asp Leu Ala Gly Gly Val Gly Ala Pro Gln Leu Val Glu Leu 
225                 230                 235                 240 


Trp Asn Leu Val Phe Met Gln His Asn Arg Glu Ala Asp Gly Ser Leu 
                245                 250                 255     


Gln Pro Leu Pro Gln Arg His Val Asp Thr Gly Met Gly Leu Glu Arg 
            260                 265                 270         


Leu Val Ala Val Leu Gln Gly Lys His Ser Thr Tyr Asp Thr Asp Leu 
        275                 280                 285             


Phe Ser Pro Leu Leu Asn Ala Ile Gln Gln Gly Cys Arg Ala Pro Pro 
    290                 295                 300                 


Tyr Leu Gly Arg Val Gly Val Ala Asp Glu Gly Arg Thr Asp Thr Ala 
305                 310                 315                 320 


Tyr Arg Val Val Ala Asp His Ile Arg Thr Leu Ser Val Cys Ile Ser 
                325                 330                 335     


Asp Gly Ile Phe Pro Gly Met Ser Gly Pro Pro Leu Val Leu Arg Arg 
            340                 345                 350         


Ile Leu Arg Arg Ala Val Arg Phe Ser Met Glu Ile Leu Lys Ala Pro 
        355                 360                 365             


Pro Gly Phe Leu Gly Ser Leu Val Pro Val Val Val Glu Thr Leu Gly 
    370                 375                 380                 


Asp Ala Tyr Pro Glu Leu Gln Arg Asn Ser Ala Gln Ile Ala Asn Leu 
385                 390                 395                 400 


Val Ser Glu Asp Glu Ala Ala Phe Leu Ala Ser Leu Glu Arg Gly Arg 
                405                 410                 415     


Arg Ile Ile Asp Arg Thr Leu Arg Thr Leu Gly Pro Ser Asp Met Phe 
            420                 425                 430         


Pro Ala Glu Val Ala Trp Ser Leu Ser Leu Cys Gly Asp Leu Gly Leu 
        435                 440                 445             


Pro Leu Asp Met Val Glu Leu Met Leu Glu Glu Lys Gly Val Gln Leu 
    450                 455                 460                 


Asp Ser Ala Gly Leu Glu Arg Leu Ala Gln Glu Glu Ala Gln His Arg 
465                 470                 475                 480 


Ala Arg Gln Ala Glu Pro Val Gln Lys Gln Gly Leu Trp Leu Asp Val 
                485                 490                 495     


His Ala Leu Gly Glu Leu Gln Arg Gln Gly Val Pro Pro Thr Asp Asp 
            500                 505                 510         


Ser Pro Lys Tyr Asn Tyr Ser Leu Arg Pro Ser Gly Ser Tyr Glu Phe 
        515                 520                 525             


Gly Thr Cys Glu Ala Gln Val Leu Gln Leu Tyr Thr Glu Asp Gly Thr 
    530                 535                 540                 


Ala Val Ala Ser Val Gly Lys Gly Gln Arg Cys Gly Leu Leu Leu Asp 
545                 550                 555                 560 


Arg Thr Asn Phe Tyr Ala Glu Gln Gly Gly Gln Ala Ser Asp Arg Gly 
                565                 570                 575     


Tyr Leu Val Arg Ala Gly Gln Glu Asp Val Leu Phe Pro Val Ala Arg 
            580                 585                 590         


Ala Gln Val Cys Gly Gly Phe Ile Leu His Glu Ala Val Ala Pro Glu 
        595                 600                 605             


Cys Leu Arg Leu Gly Asp Gln Val Gln Leu His Val Asp Glu Ala Trp 
    610                 615                 620                 


Arg Leu Gly Cys Met Ala Lys His Thr Ala Thr His Leu Leu Asn Trp 
625                 630                 635                 640 


Ala Leu Arg Gln Thr Leu Gly Pro Gly Thr Glu Gln Gln Gly Ser His 
                645                 650                 655     


Leu Asn Pro Glu Gln Leu Arg Leu Asp Val Thr Thr Gln Thr Pro Leu 
            660                 665                 670         


Thr Pro Glu Gln Leu Arg Ala Val Glu Asn Thr Val Gln Glu Ala Val 
        675                 680                 685             


Gly Gln Asp Glu Ala Val Tyr Met Glu Glu Val Pro Leu Ala Leu Thr 
    690                 695                 700                 


Ala Gln Val Pro Gly Leu Arg Ser Leu Asp Glu Val Tyr Pro Asp Pro 
705                 710                 715                 720 


Val Arg Val Val Ser Val Gly Val Pro Val Ala His Ala Leu Asp Pro 
                725                 730                 735     


Ala Ser Gln Ala Ala Leu Gln Thr Ser Val Glu Leu Cys Cys Gly Thr 
            740                 745                 750         


His Leu Leu Arg Thr Gly Ala Val Gly Asp Leu Val Ile Ile Gly Asp 
        755                 760                 765             


Arg Gln Leu Ser Lys Gly Thr Thr Arg Leu Leu Ala Val Thr Gly Glu 
    770                 775                 780                 


Gln Ala Gln Gln Ala Arg Glu Leu Gly Gln Ser Leu Ala Gln Glu Val 
785                 790                 795                 800 


Lys Ala Ala Thr Glu Arg Leu Ser Leu Gly Ser Arg Asp Val Ala Glu 
                805                 810                 815     


Ala Leu Arg Leu Ser Lys Asp Ile Gly Arg Leu Ile Glu Ala Val Glu 
            820                 825                 830         


Thr Ala Val Met Pro Gln Trp Gln Arg Arg Glu Leu Leu Ala Thr Val 
        835                 840                 845             


Lys Met Leu Gln Arg Arg Ala Asn Thr Ala Ile Arg Lys Leu Gln Met 
    850                 855                 860                 


Gly Gln Ala Ala Lys Lys Thr Gln Glu Leu Leu Glu Arg His Ser Lys 
865                 870                 875                 880 


Gly Pro Leu Ile Val Asp Thr Val Ser Ala Glu Ser Leu Ser Val Leu 
                885                 890                 895     


Val Lys Val Val Arg Gln Leu Cys Glu Gln Ala Pro Ser Thr Ser Val 
            900                 905                 910         


Leu Leu Leu Ser Pro Gln Pro Met Gly Lys Val Leu Cys Ala Cys Gln 
        915                 920                 925             


Val Ala Gln Gly Ala Met Pro Thr Phe Thr Ala Glu Ala Trp Ala Leu 
    930                 935                 940                 


Ala Val Cys Ser His Met Gly Gly Lys Ala Trp Gly Ser Arg Val Val 
945                 950                 955                 960 


Ala Gln Gly Thr Gly Ser Thr Thr Asp Leu Glu Ala Ala Leu Ser Ile 
                965                 970                 975     


Ala Gln Thr Tyr Ala Leu Ser Gln Leu 
            980                 985 


<210>  5
<211>  780
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Pro Tyr Ser Leu Leu Val Thr Arg Leu Gln Lys Ala Leu Gly 
1               5                   10                  15      


Val Arg Gln Tyr His Val Ala Ser Val Leu Cys Gln Arg Ala Lys Val 
            20                  25                  30          


Ala Met Ser His Phe Glu Pro Asn Glu Tyr Ile His Tyr Asp Leu Leu 
        35                  40                  45              


Glu Lys Asn Ile Asn Ile Val Arg Lys Arg Leu Asn Arg Pro Leu Thr 
    50                  55                  60                  


Leu Ser Glu Lys Ile Val Tyr Gly His Leu Asp Asp Pro Ala Ser Gln 
65                  70                  75                  80  


Glu Ile Glu Arg Gly Lys Ser Tyr Leu Arg Leu Arg Pro Asp Arg Val 
                85                  90                  95      


Ala Met Gln Asp Ala Thr Ala Gln Met Ala Met Leu Gln Phe Ile Ser 
            100                 105                 110         


Ser Gly Leu Ser Lys Val Ala Val Pro Ser Thr Ile His Cys Asp His 
        115                 120                 125             


Leu Ile Glu Ala Gln Val Gly Gly Glu Lys Asp Leu Arg Arg Ala Lys 
    130                 135                 140                 


Asp Ile Asn Gln Glu Val Tyr Asn Phe Leu Ala Thr Ala Gly Ala Lys 
145                 150                 155                 160 


Tyr Gly Val Gly Phe Trp Lys Pro Gly Ser Gly Ile Ile His Gln Ile 
                165                 170                 175     


Ile Leu Glu Asn Tyr Ala Tyr Pro Gly Val Leu Leu Ile Gly Thr Asp 
            180                 185                 190         


Ser His Thr Pro Asn Gly Gly Gly Leu Gly Gly Ile Cys Ile Gly Val 
        195                 200                 205             


Gly Gly Ala Asp Ala Val Asp Val Met Ala Gly Ile Pro Trp Glu Leu 
    210                 215                 220                 


Lys Cys Pro Lys Val Ile Gly Val Lys Leu Thr Gly Ser Leu Ser Gly 
225                 230                 235                 240 


Trp Ser Ser Pro Lys Asp Val Ile Leu Lys Val Ala Gly Ile Leu Thr 
                245                 250                 255     


Val Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr His Gly Pro Gly Val 
            260                 265                 270         


Asp Ser Ile Ser Cys Thr Gly Met Ala Thr Ile Cys Asn Met Gly Ala 
        275                 280                 285             


Glu Ile Gly Ala Thr Thr Ser Val Phe Pro Tyr Asn His Arg Met Lys 
    290                 295                 300                 


Lys Tyr Leu Ser Lys Thr Gly Arg Glu Asp Ile Ala Asn Leu Ala Asp 
305                 310                 315                 320 


Glu Phe Lys Asp His Leu Val Pro Asp Pro Gly Cys His Tyr Asp Gln 
                325                 330                 335     


Leu Ile Glu Ile Asn Leu Ser Glu Leu Lys Pro His Ile Asn Gly Pro 
            340                 345                 350         


Phe Thr Pro Asp Leu Ala His Pro Val Ala Glu Val Gly Lys Val Ala 
        355                 360                 365             


Glu Lys Glu Gly Trp Pro Leu Asp Ile Arg Val Gly Leu Ile Gly Ser 
    370                 375                 380                 


Cys Thr Asn Ser Ser Tyr Glu Asp Met Gly Arg Ser Ala Ala Val Ala 
385                 390                 395                 400 


Lys Gln Ala Leu Ala His Gly Leu Lys Cys Lys Ser Gln Phe Thr Ile 
                405                 410                 415     


Thr Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Tyr 
            420                 425                 430         


Ala Gln Ile Leu Arg Asp Leu Gly Gly Ile Val Leu Ala Asn Ala Cys 
        435                 440                 445             


Gly Pro Cys Ile Gly Gln Trp Asp Arg Lys Asp Ile Lys Lys Gly Glu 
    450                 455                 460                 


Lys Asn Thr Ile Val Thr Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn 
465                 470                 475                 480 


Asp Ala Asn Pro Glu Thr His Ala Phe Val Thr Ser Pro Glu Ile Val 
                485                 490                 495     


Thr Ala Leu Ala Ile Ala Gly Thr Leu Lys Phe Asn Pro Glu Thr Asp 
            500                 505                 510         


Tyr Leu Thr Gly Thr Asp Gly Lys Lys Phe Arg Leu Glu Ala Pro Asp 
        515                 520                 525             


Ala Asp Glu Leu Pro Lys Gly Glu Phe Asp Pro Gly Gln Asp Thr Tyr 
    530                 535                 540                 


Gln His Pro Pro Lys Asp Ser Ser Gly Gln His Val Asp Val Ser Pro 
545                 550                 555                 560 


Thr Ser Gln Arg Leu Gln Leu Leu Glu Pro Phe Asp Lys Trp Asp Gly 
                565                 570                 575     


Lys Asp Leu Glu Asp Leu Gln Ile Leu Ile Lys Val Lys Gly Lys Cys 
            580                 585                 590         


Thr Thr Asp His Ile Ser Ala Ala Gly Pro Trp Leu Lys Phe Arg Gly 
        595                 600                 605             


His Leu Asp Asn Ile Ser Asn Asn Leu Leu Ile Gly Ala Ile Asn Ile 
    610                 615                 620                 


Glu Asn Gly Lys Ala Asn Ser Val Arg Asn Ala Val Thr Gln Glu Phe 
625                 630                 635                 640 


Gly Pro Val Pro Asp Thr Ala Arg Tyr Tyr Lys Lys His Gly Ile Arg 
                645                 650                 655     


Trp Val Val Ile Gly Asp Glu Asn Tyr Gly Glu Gly Ser Ser Arg Glu 
            660                 665                 670         


His Ala Ala Leu Glu Pro Arg His Leu Gly Gly Arg Ala Ile Ile Thr 
        675                 680                 685             


Lys Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu 
    690                 695                 700                 


Leu Pro Leu Thr Phe Ala Asp Pro Ala Asp Tyr Asn Lys Ile His Pro 
705                 710                 715                 720 


Val Asp Lys Leu Thr Ile Gln Gly Leu Lys Asp Phe Thr Pro Gly Lys 
                725                 730                 735     


Pro Leu Lys Cys Ile Ile Lys His Pro Asn Gly Thr Gln Glu Thr Ile 
            740                 745                 750         


Leu Leu Asn His Thr Phe Asn Glu Thr Gln Ile Glu Trp Phe Arg Ala 
        755                 760                 765             


Gly Ser Ala Leu Asn Arg Met Lys Glu Leu Gln Gln 
    770                 775                 780 


<210>  6
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 


<210>  7
<211>  848
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asn Ser Ser Ser Ala Asn Ile Thr Tyr Ala Ser Arg Lys Arg Arg 
1               5                   10                  15      


Lys Pro Val Gln Lys Thr Val Lys Pro Ile Pro Ala Glu Gly Ile Lys 
            20                  25                  30          


Ser Asn Pro Ser Lys Arg His Arg Asp Arg Leu Asn Thr Glu Leu Asp 
        35                  40                  45              


Arg Leu Ala Ser Leu Leu Pro Phe Pro Gln Asp Val Ile Asn Lys Leu 
    50                  55                  60                  


Asp Lys Leu Ser Val Leu Arg Leu Ser Val Ser Tyr Leu Arg Ala Lys 
65                  70                  75                  80  


Ser Phe Phe Asp Val Ala Leu Lys Ser Ser Pro Thr Glu Arg Asn Gly 
                85                  90                  95      


Gly Gln Asp Asn Cys Arg Ala Ala Asn Phe Arg Glu Gly Leu Asn Leu 
            100                 105                 110         


Gln Glu Gly Glu Phe Leu Leu Gln Ala Leu Asn Gly Phe Val Leu Val 
        115                 120                 125             


Val Thr Thr Asp Ala Leu Val Phe Tyr Ala Ser Ser Thr Ile Gln Asp 
    130                 135                 140                 


Tyr Leu Gly Phe Gln Gln Ser Asp Val Ile His Gln Ser Val Tyr Glu 
145                 150                 155                 160 


Leu Ile His Thr Glu Asp Arg Ala Glu Phe Gln Arg Gln Leu His Trp 
                165                 170                 175     


Ala Leu Asn Pro Ser Gln Cys Thr Glu Ser Gly Gln Gly Ile Glu Glu 
            180                 185                 190         


Ala Thr Gly Leu Pro Gln Thr Val Val Cys Tyr Asn Pro Asp Gln Ile 
        195                 200                 205             


Pro Pro Glu Asn Ser Pro Leu Met Glu Arg Cys Phe Ile Cys Arg Leu 
    210                 215                 220                 


Arg Cys Leu Leu Asp Asn Ser Ser Gly Phe Leu Ala Met Asn Phe Gln 
225                 230                 235                 240 


Gly Lys Leu Lys Tyr Leu His Gly Gln Lys Lys Lys Gly Lys Asp Gly 
                245                 250                 255     


Ser Ile Leu Pro Pro Gln Leu Ala Leu Phe Ala Ile Ala Thr Pro Leu 
            260                 265                 270         


Gln Pro Pro Ser Ile Leu Glu Ile Arg Thr Lys Asn Phe Ile Phe Arg 
        275                 280                 285             


Thr Lys His Lys Leu Asp Phe Thr Pro Ile Gly Cys Asp Ala Lys Gly 
    290                 295                 300                 


Arg Ile Val Leu Gly Tyr Thr Glu Ala Glu Leu Cys Thr Arg Gly Ser 
305                 310                 315                 320 


Gly Tyr Gln Phe Ile His Ala Ala Asp Met Leu Tyr Cys Ala Glu Ser 
                325                 330                 335     


His Ile Arg Met Ile Lys Thr Gly Glu Ser Gly Met Ile Val Phe Arg 
            340                 345                 350         


Leu Leu Thr Lys Asn Asn Arg Trp Thr Trp Val Gln Ser Asn Ala Arg 
        355                 360                 365             


Leu Leu Tyr Lys Asn Gly Arg Pro Asp Tyr Ile Ile Val Thr Gln Arg 
    370                 375                 380                 


Pro Leu Thr Asp Glu Glu Gly Thr Glu His Leu Arg Lys Arg Asn Thr 
385                 390                 395                 400 


Lys Leu Pro Phe Met Phe Thr Thr Gly Glu Ala Val Leu Tyr Glu Ala 
                405                 410                 415     


Thr Asn Pro Phe Pro Ala Ile Met Asp Pro Leu Pro Leu Arg Thr Lys 
            420                 425                 430         


Asn Gly Thr Ser Gly Lys Asp Ser Ala Thr Thr Ser Thr Leu Ser Lys 
        435                 440                 445             


Asp Ser Leu Asn Pro Ser Ser Leu Leu Ala Ala Met Met Gln Gln Asp 
    450                 455                 460                 


Glu Ser Ile Tyr Leu Tyr Pro Ala Ser Ser Thr Ser Ser Thr Ala Pro 
465                 470                 475                 480 


Phe Glu Asn Asn Phe Phe Asn Glu Ser Met Asn Glu Cys Arg Asn Trp 
                485                 490                 495     


Gln Asp Asn Thr Ala Pro Met Gly Asn Asp Thr Ile Leu Lys His Glu 
            500                 505                 510         


Gln Ile Asp Gln Pro Gln Asp Val Asn Ser Phe Ala Gly Gly His Pro 
        515                 520                 525             


Gly Leu Phe Gln Asp Ser Lys Asn Ser Asp Leu Tyr Ser Ile Met Lys 
    530                 535                 540                 


Asn Leu Gly Ile Asp Phe Glu Asp Ile Arg His Met Gln Asn Glu Lys 
545                 550                 555                 560 


Phe Phe Arg Asn Asp Phe Ser Gly Glu Val Asp Phe Arg Asp Ile Asp 
                565                 570                 575     


Leu Thr Asp Glu Ile Leu Thr Tyr Val Gln Asp Ser Leu Ser Lys Ser 
            580                 585                 590         


Pro Phe Ile Pro Ser Asp Tyr Gln Gln Gln Gln Ser Leu Ala Leu Asn 
        595                 600                 605             


Ser Ser Cys Met Val Gln Glu His Leu His Leu Glu Gln Gln Gln Gln 
    610                 615                 620                 


His His Gln Lys Gln Val Val Val Glu Pro Gln Gln Gln Leu Cys Gln 
625                 630                 635                 640 


Lys Met Lys His Met Gln Val Asn Gly Met Phe Glu Asn Trp Asn Ser 
                645                 650                 655     


Asn Gln Phe Val Pro Phe Asn Cys Pro Gln Gln Asp Pro Gln Gln Tyr 
            660                 665                 670         


Asn Val Phe Thr Asp Leu His Gly Ile Ser Gln Glu Phe Pro Tyr Lys 
        675                 680                 685             


Ser Glu Met Asp Ser Met Pro Tyr Thr Gln Asn Phe Ile Ser Cys Asn 
    690                 695                 700                 


Gln Pro Val Leu Pro Gln His Ser Lys Cys Thr Glu Leu Asp Tyr Pro 
705                 710                 715                 720 


Met Gly Ser Phe Glu Pro Ser Pro Tyr Pro Thr Thr Ser Ser Leu Glu 
                725                 730                 735     


Asp Phe Val Thr Cys Leu Gln Leu Pro Glu Asn Gln Lys His Gly Leu 
            740                 745                 750         


Asn Pro Gln Ser Ala Ile Ile Thr Pro Gln Thr Cys Tyr Ala Gly Ala 
        755                 760                 765             


Val Ser Met Tyr Gln Cys Gln Pro Glu Pro Gln His Thr His Val Gly 
    770                 775                 780                 


Gln Met Gln Tyr Asn Pro Val Leu Pro Gly Gln Gln Ala Phe Leu Asn 
785                 790                 795                 800 


Lys Phe Gln Asn Gly Val Leu Asn Glu Thr Tyr Pro Ala Glu Leu Asn 
                805                 810                 815     


Asn Ile Asn Asn Thr Gln Thr Thr Thr His Leu Gln Pro Leu His His 
            820                 825                 830         


Pro Ser Glu Ala Arg Pro Phe Pro Asp Leu Thr Ser Ser Gly Phe Leu 
        835                 840                 845             


<210>  8
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  9
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ala Thr Leu Arg Pro Tyr Leu Ser Ala Val Arg Ala Thr Leu 
1               5                   10                  15      


Gln Ala Ala Leu Cys Leu Glu Asn Phe Ser Ser Gln Val Val Glu Arg 
            20                  25                  30          


His Asn Lys Pro Glu Val Glu Val Arg Ser Ser Lys Glu Leu Leu Leu 
        35                  40                  45              


Gln Pro Val Thr Ile Ser Arg Asn Glu Lys Glu Lys Val Leu Ile Glu 
    50                  55                  60                  


Gly Ser Ile Asn Ser Val Arg Val Ser Ile Ala Val Lys Gln Ala Asp 
65                  70                  75                  80  


Glu Ile Glu Lys Ile Leu Cys His Lys Phe Met Arg Phe Met Met Met 
                85                  90                  95      


Arg Ala Glu Asn Phe Phe Ile Leu Arg Arg Lys Pro Val Glu Gly Tyr 
            100                 105                 110         


Asp Ile Ser Phe Leu Ile Thr Asn Phe His Thr Glu Gln Met Tyr Lys 
        115                 120                 125             


His Lys Leu Val Asp Phe Val Ile His Phe Met Glu Glu Ile Asp Lys 
    130                 135                 140                 


Glu Ile Ser Glu Met Lys Leu Ser Val Asn Ala Arg Ala Arg Ile Val 
145                 150                 155                 160 


Ala Glu Glu Phe Leu Lys Asn Phe 
                165             


<210>  10
<211>  553
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ser Val Arg Val Ala Ala Ala Val Val Arg Ala Leu Pro Arg 
1               5                   10                  15      


Arg Ala Gly Leu Val Ser Arg Asn Ala Leu Gly Ser Ser Phe Ile Ala 
            20                  25                  30          


Ala Arg Asn Phe His Ala Ser Asn Thr His Leu Gln Lys Thr Gly Thr 
        35                  40                  45              


Ala Glu Met Ser Ser Ile Leu Glu Glu Arg Ile Leu Gly Ala Asp Thr 
    50                  55                  60                  


Ser Val Asp Leu Glu Glu Thr Gly Arg Val Leu Ser Ile Gly Asp Gly 
65                  70                  75                  80  


Ile Ala Arg Val His Gly Leu Arg Asn Val Gln Ala Glu Glu Met Val 
                85                  90                  95      


Glu Phe Ser Ser Gly Leu Lys Gly Met Ser Leu Asn Leu Glu Pro Asp 
            100                 105                 110         


Asn Val Gly Val Val Val Phe Gly Asn Asp Lys Leu Ile Lys Glu Gly 
        115                 120                 125             


Asp Ile Val Lys Arg Thr Gly Ala Ile Val Asp Val Pro Val Gly Glu 
    130                 135                 140                 


Glu Leu Leu Gly Arg Val Val Asp Ala Leu Gly Asn Ala Ile Asp Gly 
145                 150                 155                 160 


Lys Gly Pro Ile Gly Ser Lys Thr Arg Arg Arg Val Gly Leu Lys Ala 
                165                 170                 175     


Pro Gly Ile Ile Pro Arg Ile Ser Val Arg Glu Pro Met Gln Thr Gly 
            180                 185                 190         


Ile Lys Ala Val Asp Ser Leu Val Pro Ile Gly Arg Gly Gln Arg Glu 
        195                 200                 205             


Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr Ser Ile Ala Ile Asp 
    210                 215                 220                 


Thr Ile Ile Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys 
225                 230                 235                 240 


Lys Leu Tyr Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val 
                245                 250                 255     


Ala Gln Leu Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr 
            260                 265                 270         


Ile Val Val Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu 
        275                 280                 285             


Ala Pro Tyr Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly 
    290                 295                 300                 


Lys His Ala Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala 
305                 310                 315                 320 


Tyr Arg Gln Met Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala 
                325                 330                 335     


Tyr Pro Gly Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ala 
            340                 345                 350         


Ala Lys Met Asn Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro 
        355                 360                 365             


Val Ile Glu Thr Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn 
    370                 375                 380                 


Val Ile Ser Ile Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe 
385                 390                 395                 400 


Tyr Lys Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg 
                405                 410                 415     


Val Gly Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr 
            420                 425                 430         


Met Lys Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln 
        435                 440                 445             


Phe Gly Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly 
    450                 455                 460                 


Val Arg Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala 
465                 470                 475                 480 


Ile Glu Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu 
                485                 490                 495     


Asp Lys Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu 
            500                 505                 510         


Ser His Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala 
        515                 520                 525             


Asp Gly Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val 
    530                 535                 540                 


Thr Asn Phe Leu Ala Gly Phe Glu Ala 
545                 550             


<210>  11
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210>  12
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Phe Ser Lys Leu Pro Lys Ile Leu Asp Glu Asp Lys Glu Ser 
1               5                   10                  15      


Thr Phe Gly Tyr Val His Gly Val Ser Gly Pro Val Val Thr Ala Cys 
            20                  25                  30          


Asp Met Ala Gly Ala Ala Met Tyr Glu Leu Val Arg Val Gly His Ser 
        35                  40                  45              


Glu Leu Val Gly Glu Ile Ile Arg Leu Glu Gly Asp Met Ala Thr Ile 
    50                  55                  60                  


Gln Val Tyr Glu Glu Thr Ser Gly Val Ser Val Gly Asp Pro Val Leu 
65                  70                  75                  80  


Arg Thr Gly Lys Pro Leu Ser Val Glu Leu Gly Pro Gly Ile Met Gly 
                85                  90                  95      


Ala Ile Phe Asp Gly Ile Gln Arg Pro Leu Ser Asp Ile Ser Ser Gln 
            100                 105                 110         


Thr Gln Ser Ile Tyr Ile Pro Arg Gly Val Asn Val Ser Ala Leu Ser 
        115                 120                 125             


Arg Asp Ile Lys Trp Asp Phe Thr Pro Cys Lys Asn Leu Arg Val Gly 
    130                 135                 140                 


Ser His Ile Thr Gly Gly Asp Ile Tyr Gly Ile Val Ser Glu Asn Ser 
145                 150                 155                 160 


Leu Ile Lys His Lys Ile Met Leu Pro Pro Arg Asn Arg Gly Thr Val 
                165                 170                 175     


Thr Tyr Ile Ala Pro Pro Gly Asn Tyr Asp Thr Ser Asp Val Val Leu 
            180                 185                 190         


Glu Leu Glu Phe Glu Gly Val Lys Glu Lys Phe Thr Met Val Gln Val 
        195                 200                 205             


Trp Pro Val Arg Gln Val Arg Pro Val Thr Glu Lys Leu Pro Ala Asn 
    210                 215                 220                 


His Pro Leu Leu Thr Gly Gln Arg Val Leu Asp Ala Leu Phe Pro Cys 
225                 230                 235                 240 


Val Gln Gly Gly Thr Thr Ala Ile Pro Gly Ala Phe Gly Cys Gly Lys 
                245                 250                 255     


Thr Val Ile Ser Gln Ser Leu Ser Lys Tyr Ser Asn Ser Asp Val Ile 
            260                 265                 270         


Ile Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Ser Glu Val Leu 
        275                 280                 285             


Arg Asp Phe Pro Glu Leu Thr Met Glu Val Asp Gly Lys Val Glu Ser 
    290                 295                 300                 


Ile Met Lys Arg Thr Ala Leu Val Ala Asn Thr Ser Asn Met Pro Val 
305                 310                 315                 320 


Ala Ala Arg Glu Ala Ser Ile Tyr Thr Gly Ile Thr Leu Ser Glu Tyr 
                325                 330                 335     


Phe Arg Asp Met Gly Tyr His Val Ser Met Met Ala Asp Ser Thr Ser 
            340                 345                 350         


Arg Trp Ala Glu Ala Leu Arg Glu Ile Ser Gly Arg Leu Ala Glu Met 
        355                 360                 365             


Pro Ala Asp Ser Gly Tyr Pro Ala Tyr Leu Gly Ala Arg Leu Ala Ser 
    370                 375                 380                 


Phe Tyr Glu Arg Ala Gly Arg Val Lys Cys Leu Gly Asn Pro Glu Arg 
385                 390                 395                 400 


Glu Gly Ser Val Ser Ile Val Gly Ala Val Ser Pro Pro Gly Gly Asp 
                405                 410                 415     


Phe Ser Asp Pro Val Thr Ser Ala Thr Leu Gly Ile Val Gln Val Phe 
            420                 425                 430         


Trp Gly Leu Asp Lys Lys Leu Ala Gln Arg Lys His Phe Pro Ser Val 
        435                 440                 445             


Asn Trp Leu Ile Ser Tyr Ser Lys Tyr Met Arg Ala Leu Asp Glu Tyr 
    450                 455                 460                 


Tyr Asp Lys His Phe Thr Glu Phe Val Pro Leu Arg Thr Lys Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Gln Glu Glu Glu Asp Leu Ala Glu Ile Val Gln Leu Val 
                485                 490                 495     


Gly Lys Ala Ser Leu Ala Glu Thr Asp Lys Ile Thr Leu Glu Val Ala 
            500                 505                 510         


Lys Leu Ile Lys Asp Asp Phe Leu Gln Gln Asn Gly Tyr Thr Pro Tyr 
        515                 520                 525             


Asp Arg Phe Cys Pro Phe Tyr Lys Thr Val Gly Met Leu Ser Asn Met 
    530                 535                 540                 


Ile Ala Phe Tyr Asp Met Ala Arg Arg Ala Val Glu Thr Thr Ala Gln 
545                 550                 555                 560 


Ser Asp Asn Lys Ile Thr Trp Ser Ile Ile Arg Glu His Met Gly Asp 
                565                 570                 575     


Ile Leu Tyr Lys Leu Ser Ser Met Lys Phe Lys Asp Pro Leu Lys Asp 
            580                 585                 590         


Gly Glu Ala Lys Ile Lys Ser Asp Tyr Ala Gln Leu Leu Glu Asp Met 
        595                 600                 605             


Gln Asn Ala Phe Arg Ser Leu Glu Asp 
    610                 615         


<210>  13
<211>  1164
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Thr Met Arg Arg Thr Val Ser Glu Ile Arg Ser Arg Ala Glu 
1               5                   10                  15      


Gly Tyr Glu Lys Thr Asp Asp Val Ser Glu Lys Thr Ser Leu Ala Asp 
            20                  25                  30          


Gln Glu Glu Val Arg Thr Ile Phe Ile Asn Gln Pro Gln Leu Thr Lys 
        35                  40                  45              


Phe Cys Asn Asn His Val Ser Thr Ala Lys Tyr Asn Ile Ile Thr Phe 
    50                  55                  60                  


Leu Pro Arg Phe Leu Tyr Ser Gln Phe Arg Arg Ala Ala Asn Ser Phe 
65                  70                  75                  80  


Phe Leu Phe Ile Ala Leu Leu Gln Gln Ile Pro Asp Val Ser Pro Thr 
                85                  90                  95      


Gly Arg Tyr Thr Thr Leu Val Pro Leu Leu Phe Ile Leu Ala Val Ala 
            100                 105                 110         


Ala Ile Lys Glu Ile Ile Glu Asp Ile Lys Arg His Lys Ala Asp Asn 
        115                 120                 125             


Ala Val Asn Lys Lys Gln Thr Gln Val Leu Arg Asn Gly Ala Trp Glu 
    130                 135                 140                 


Ile Val His Trp Glu Lys Val Ala Val Gly Glu Ile Val Lys Val Thr 
145                 150                 155                 160 


Asn Gly Glu His Leu Pro Ala Asp Leu Ile Ser Leu Ser Ser Ser Glu 
                165                 170                 175     


Pro Gln Ala Met Cys Tyr Ile Glu Thr Ser Asn Leu Asp Gly Glu Thr 
            180                 185                 190         


Asn Leu Lys Ile Arg Gln Gly Leu Pro Ala Thr Ser Asp Ile Lys Asp 
        195                 200                 205             


Val Asp Ser Leu Met Arg Ile Ser Gly Arg Ile Glu Cys Glu Ser Pro 
    210                 215                 220                 


Asn Arg His Leu Tyr Asp Phe Val Gly Asn Ile Arg Leu Asp Gly His 
225                 230                 235                 240 


Gly Thr Val Pro Leu Gly Ala Asp Gln Ile Leu Leu Arg Gly Ala Gln 
                245                 250                 255     


Leu Arg Asn Thr Gln Trp Val His Gly Ile Val Val Tyr Thr Gly His 
            260                 265                 270         


Asp Thr Lys Leu Met Gln Asn Ser Thr Ser Pro Pro Leu Lys Leu Ser 
        275                 280                 285             


Asn Val Glu Arg Ile Thr Asn Val Gln Ile Leu Ile Leu Phe Cys Ile 
    290                 295                 300                 


Leu Ile Ala Met Ser Leu Val Cys Ser Val Gly Ser Ala Ile Trp Asn 
305                 310                 315                 320 


Arg Arg His Ser Gly Lys Asp Trp Tyr Leu Asn Leu Asn Tyr Gly Gly 
                325                 330                 335     


Ala Ser Asn Phe Gly Leu Asn Phe Leu Thr Phe Ile Ile Leu Phe Asn 
            340                 345                 350         


Asn Leu Ile Pro Ile Ser Leu Leu Val Thr Leu Glu Val Val Lys Phe 
        355                 360                 365             


Thr Gln Ala Tyr Phe Ile Asn Trp Asp Leu Asp Met His Tyr Glu Pro 
    370                 375                 380                 


Thr Asp Thr Ala Ala Met Ala Arg Thr Ser Asn Leu Asn Glu Glu Leu 
385                 390                 395                 400 


Gly Gln Val Lys Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Cys 
                405                 410                 415     


Asn Val Met Gln Phe Lys Lys Cys Thr Ile Ala Gly Val Ala Tyr Gly 
            420                 425                 430         


His Val Pro Glu Pro Glu Asp Tyr Gly Cys Ser Pro Asp Glu Trp Gln 
        435                 440                 445             


Asn Ser Gln Phe Gly Asp Glu Lys Thr Phe Ser Asp Ser Ser Leu Leu 
    450                 455                 460                 


Glu Asn Leu Gln Asn Asn His Pro Thr Ala Pro Ile Ile Cys Glu Phe 
465                 470                 475                 480 


Leu Thr Met Met Ala Val Cys His Thr Ala Val Pro Glu Arg Glu Gly 
                485                 490                 495     


Asp Lys Ile Ile Tyr Gln Ala Ala Ser Pro Asp Glu Gly Ala Leu Val 
            500                 505                 510         


Arg Ala Ala Lys Gln Leu Asn Phe Val Phe Thr Gly Arg Thr Pro Asp 
        515                 520                 525             


Ser Val Ile Ile Asp Ser Leu Gly Gln Glu Glu Arg Tyr Glu Leu Leu 
    530                 535                 540                 


Asn Val Leu Glu Phe Thr Ser Ala Arg Lys Arg Met Ser Val Ile Val 
545                 550                 555                 560 


Arg Thr Pro Ser Gly Lys Leu Arg Leu Tyr Cys Lys Gly Ala Asp Thr 
                565                 570                 575     


Val Ile Tyr Asp Arg Leu Ala Glu Thr Ser Lys Tyr Lys Glu Ile Thr 
            580                 585                 590         


Leu Lys His Leu Glu Gln Phe Ala Thr Glu Gly Leu Arg Thr Leu Cys 
        595                 600                 605             


Phe Ala Val Ala Glu Ile Ser Glu Ser Asp Phe Gln Glu Trp Arg Ala 
    610                 615                 620                 


Val Tyr Gln Arg Ala Ser Thr Ser Val Gln Asn Arg Leu Leu Lys Leu 
625                 630                 635                 640 


Glu Glu Ser Tyr Glu Leu Ile Glu Lys Asn Leu Gln Leu Leu Gly Ala 
                645                 650                 655     


Thr Ala Ile Glu Asp Lys Leu Gln Asp Gln Val Pro Glu Thr Ile Glu 
            660                 665                 670         


Thr Leu Met Lys Ala Asp Ile Lys Ile Trp Ile Leu Thr Gly Asp Lys 
        675                 680                 685             


Gln Glu Thr Ala Ile Asn Ile Gly His Ser Cys Lys Leu Leu Lys Lys 
    690                 695                 700                 


Asn Met Gly Met Ile Val Ile Asn Glu Gly Ser Leu Asp Gly Thr Arg 
705                 710                 715                 720 


Glu Thr Leu Ser Arg His Cys Thr Thr Leu Gly Asp Ala Leu Arg Lys 
                725                 730                 735     


Glu Asn Asp Phe Ala Leu Ile Ile Asp Gly Lys Thr Leu Lys Tyr Ala 
            740                 745                 750         


Leu Thr Phe Gly Val Arg Gln Tyr Phe Leu Asp Leu Ala Leu Ser Cys 
        755                 760                 765             


Lys Ala Val Ile Cys Cys Arg Val Ser Pro Leu Gln Lys Ser Glu Val 
    770                 775                 780                 


Val Glu Met Val Lys Lys Gln Val Lys Val Val Thr Leu Ala Ile Gly 
785                 790                 795                 800 


Asp Gly Ala Asn Asp Val Ser Met Ile Gln Thr Ala His Val Gly Val 
                805                 810                 815     


Gly Ile Ser Gly Asn Glu Gly Leu Gln Ala Ala Asn Ser Ser Asp Tyr 
            820                 825                 830         


Ser Ile Ala Gln Phe Lys Tyr Leu Lys Asn Leu Leu Met Ile His Gly 
        835                 840                 845             


Ala Trp Asn Tyr Asn Arg Val Ser Lys Cys Ile Leu Tyr Cys Phe Tyr 
    850                 855                 860                 


Lys Asn Ile Val Leu Tyr Ile Ile Glu Ile Trp Phe Ala Phe Val Asn 
865                 870                 875                 880 


Gly Phe Ser Gly Gln Ile Leu Phe Glu Arg Trp Cys Ile Gly Leu Tyr 
                885                 890                 895     


Asn Val Met Phe Thr Ala Met Pro Pro Leu Thr Leu Gly Ile Phe Glu 
            900                 905                 910         


Arg Ser Cys Arg Lys Glu Asn Met Leu Lys Tyr Pro Glu Leu Tyr Lys 
        915                 920                 925             


Thr Ser Gln Asn Ala Leu Asp Phe Asn Thr Lys Val Phe Trp Val His 
    930                 935                 940                 


Cys Leu Asn Gly Leu Phe His Ser Val Ile Leu Phe Trp Phe Pro Leu 
945                 950                 955                 960 


Lys Ala Leu Gln Tyr Gly Thr Ala Phe Gly Asn Gly Lys Thr Ser Asp 
                965                 970                 975     


Tyr Leu Leu Leu Gly Asn Phe Val Tyr Thr Phe Val Val Ile Thr Val 
            980                 985                 990         


Cys Leu Lys Ala Gly Leu Glu Thr  Ser Tyr Trp Thr Trp  Phe Ser His 
        995                 1000                 1005             


Ile Ala  Ile Trp Gly Ser Ile  Ala Leu Trp Val Val  Phe Phe Gly 
    1010                 1015                 1020             


Ile Tyr  Ser Ser Leu Trp Pro  Ala Ile Pro Met Ala  Pro Asp Met 
    1025                 1030                 1035             


Ser Gly  Glu Ala Ala Met Leu  Phe Ser Ser Gly Val  Phe Trp Met 
    1040                 1045                 1050             


Gly Leu  Leu Phe Ile Pro Val  Ala Ser Leu Leu Leu  Asp Val Val 
    1055                 1060                 1065             


Tyr Lys  Val Ile Lys Arg Thr  Ala Phe Lys Thr Leu  Val Asp Glu 
    1070                 1075                 1080             


Val Gln  Glu Leu Glu Ala Lys  Ser Gln Asp Pro Gly  Ala Val Val 
    1085                 1090                 1095             


Leu Gly  Lys Ser Leu Thr Glu  Arg Ala Gln Leu Leu  Lys Asn Val 
    1100                 1105                 1110             


Phe Lys  Lys Asn His Val Asn  Leu Tyr Arg Ser Glu  Ser Leu Gln 
    1115                 1120                 1125             


Gln Asn  Leu Leu His Gly Tyr  Ala Phe Ser Gln Asp  Glu Asn Gly 
    1130                 1135                 1140             


Ile Val  Ser Gln Ser Glu Val  Ile Arg Ala Tyr Asp  Thr Thr Lys 
    1145                 1150                 1155             


Gln Arg  Pro Asp Glu Trp 
    1160                 


<210>  14
<211>  2644
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  15
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Val Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  16
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Lys Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  17
<211>  1362
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Gly Asp 
    130                 135                 140                 


Asp Ile Val Leu Met Ala Glu Ala Leu Glu Lys Leu Phe Leu Gln Lys 
145                 150                 155                 160 


Ile Asn Glu Leu Pro Thr Glu Glu Thr Glu Ile Met Ile Val Gln Ala 
                165                 170                 175     


Lys Gly Arg Gly Arg Gly Arg Lys Glu Thr Gly Thr Ala Lys Pro Gly 
            180                 185                 190         


Val Ser Thr Val Pro Asn Thr Thr Gln Ala Ser Thr Pro Pro Gln Thr 
        195                 200                 205             


Gln Thr Pro Gln Pro Asn Pro Pro Pro Val Gln Ala Thr Pro His Pro 
    210                 215                 220                 


Phe Pro Ala Val Thr Pro Asp Leu Ile Val Gln Thr Pro Val Met Thr 
225                 230                 235                 240 


Val Val Pro Pro Gln Pro Leu Gln Thr Pro Pro Pro Val Pro Pro Gln 
                245                 250                 255     


Pro Gln Pro Pro Pro Ala Pro Ala Pro Gln Pro Val Gln Ser His Pro 
            260                 265                 270         


Pro Ile Ile Ala Ala Thr Pro Gln Pro Val Lys Thr Lys Lys Gly Val 
        275                 280                 285             


Lys Arg Lys Ala Asp Thr Thr Thr Pro Thr Thr Ile Asp Pro Ile His 
    290                 295                 300                 


Glu Pro Pro Ser Leu Pro Pro Glu Pro Lys Thr Thr Lys Leu Gly Gln 
305                 310                 315                 320 


Arg Arg Glu Ser Ser Arg Pro Val Lys Pro Pro Lys Lys Asp Val Pro 
                325                 330                 335     


Asp Ser Gln Gln His Pro Ala Pro Glu Lys Ser Ser Lys Val Ser Glu 
            340                 345                 350         


Gln Leu Lys Cys Cys Ser Gly Ile Leu Lys Glu Met Phe Ala Lys Lys 
        355                 360                 365             


His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu Ala 
    370                 375                 380                 


Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp Met 
385                 390                 395                 400 


Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala Gln 
                405                 410                 415     


Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr 
            420                 425                 430         


Asn Pro Pro Asp His Glu Val Val Ala Met Ala Arg Lys Leu Gln Asp 
        435                 440                 445             


Val Phe Glu Met Arg Phe Ala Lys Met Pro Asp Glu Pro Glu Glu Pro 
    450                 455                 460                 


Val Val Ala Val Ser Ser Pro Ala Val Pro Pro Pro Thr Lys Val Val 
465                 470                 475                 480 


Ala Pro Pro Ser Ser Ser Asp Ser Ser Ser Asp Ser Ser Ser Asp Ser 
                485                 490                 495     


Asp Ser Ser Thr Asp Asp Ser Glu Glu Glu Arg Ala Gln Arg Leu Ala 
            500                 505                 510         


Glu Leu Gln Glu Gln Leu Lys Ala Val His Glu Gln Leu Ala Ala Leu 
        515                 520                 525             


Ser Gln Pro Gln Gln Asn Lys Pro Lys Lys Lys Glu Lys Asp Lys Lys 
    530                 535                 540                 


Glu Lys Lys Lys Glu Lys His Lys Arg Lys Glu Glu Val Glu Glu Asn 
545                 550                 555                 560 


Lys Lys Ser Lys Ala Lys Glu Pro Pro Pro Lys Lys Thr Lys Lys Asn 
                565                 570                 575     


Asn Ser Ser Asn Ser Asn Val Ser Lys Lys Glu Pro Ala Pro Met Lys 
            580                 585                 590         


Ser Lys Pro Pro Pro Thr Tyr Glu Ser Glu Glu Glu Asp Lys Cys Lys 
        595                 600                 605             


Pro Met Ser Tyr Glu Glu Lys Arg Gln Leu Ser Leu Asp Ile Asn Lys 
    610                 615                 620                 


Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile Gln Ser Arg 
625                 630                 635                 640 


Glu Pro Ser Leu Lys Asn Ser Asn Pro Asp Glu Ile Glu Ile Asp Phe 
                645                 650                 655     


Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg Tyr Val Thr 
            660                 665                 670         


Ser Cys Leu Arg Lys Lys Arg Lys Pro Gln Ala Glu Lys Val Asp Val 
        675                 680                 685             


Ile Ala Gly Ser Ser Lys Met Lys Gly Phe Ser Ser Ser Glu Ser Glu 
    690                 695                 700                 


Ser Ser Ser Glu Ser Ser Ser Ser Asp Ser Glu Asp Ser Glu Thr Glu 
705                 710                 715                 720 


Met Ala Pro Lys Ser Lys Lys Lys Gly His Pro Gly Arg Glu Gln Lys 
                725                 730                 735     


Lys His His His His His His Gln Gln Met Gln Gln Ala Pro Ala Pro 
            740                 745                 750         


Val Pro Gln Gln Pro Pro Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro 
        755                 760                 765             


Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Ser 
    770                 775                 780                 


Met Pro Gln Gln Ala Ala Pro Ala Met Lys Ser Ser Pro Pro Pro Phe 
785                 790                 795                 800 


Ile Ala Thr Gln Val Pro Val Leu Glu Pro Gln Leu Pro Gly Ser Val 
                805                 810                 815     


Phe Asp Pro Ile Gly His Phe Thr Gln Pro Ile Leu His Leu Pro Gln 
            820                 825                 830         


Pro Glu Leu Pro Pro His Leu Pro Gln Pro Pro Glu His Ser Thr Pro 
        835                 840                 845             


Pro His Leu Asn Gln His Ala Val Val Ser Pro Pro Ala Leu His Asn 
    850                 855                 860                 


Ala Leu Pro Gln Gln Pro Ser Arg Pro Ser Asn Arg Ala Ala Ala Leu 
865                 870                 875                 880 


Pro Pro Lys Pro Ala Arg Pro Pro Ala Val Ser Pro Ala Leu Thr Gln 
                885                 890                 895     


Thr Pro Leu Leu Pro Gln Pro Pro Met Ala Gln Pro Pro Gln Val Leu 
            900                 905                 910         


Leu Glu Asp Glu Glu Pro Pro Ala Pro Pro Leu Thr Ser Met Gln Met 
        915                 920                 925             


Gln Leu Tyr Leu Gln Gln Leu Gln Lys Val Gln Pro Pro Thr Pro Leu 
    930                 935                 940                 


Leu Pro Ser Val Lys Val Gln Ser Gln Pro Pro Pro Pro Leu Pro Pro 
945                 950                 955                 960 


Pro Pro His Pro Ser Val Gln Gln Gln Leu Gln Gln Gln Pro Pro Pro 
                965                 970                 975     


Pro Pro Pro Pro Gln Pro Gln Pro Pro Pro Gln Gln Gln His Gln Pro 
            980                 985                 990         


Pro Pro Arg Pro Val His Leu Gln  Pro Met Gln Phe Ser  Thr His Ile 
        995                 1000                 1005             


Gln Gln  Pro Pro Pro Pro Gln  Gly Gln Gln Pro Pro  His Pro Pro 
    1010                 1015                 1020             


Pro Gly  Gln Gln Pro Pro Pro  Pro Gln Pro Ala Lys  Pro Gln Gln 
    1025                 1030                 1035             


Val Ile  Gln His His His Ser  Pro Arg His His Lys  Ser Asp Pro 
    1040                 1045                 1050             


Tyr Ser  Thr Gly His Leu Arg  Glu Ala Pro Ser Pro  Leu Met Ile 
    1055                 1060                 1065             


His Ser  Pro Gln Met Ser Gln  Phe Gln Ser Leu Thr  His Gln Ser 
    1070                 1075                 1080             


Pro Pro  Gln Gln Asn Val Gln  Pro Lys Lys Gln Glu  Leu Arg Ala 
    1085                 1090                 1095             


Ala Ser  Val Val Gln Pro Gln  Pro Leu Val Val Val  Lys Glu Glu 
    1100                 1105                 1110             


Lys Ile  His Ser Pro Ile Ile  Arg Ser Glu Pro Phe  Ser Pro Ser 
    1115                 1120                 1125             


Leu Arg  Pro Glu Pro Pro Lys  His Pro Glu Ser Ile  Lys Ala Pro 
    1130                 1135                 1140             


Val His  Leu Pro Gln Arg Pro  Glu Met Lys Pro Val  Asp Val Gly 
    1145                 1150                 1155             


Arg Pro  Val Ile Arg Pro Pro  Glu Gln Asn Ala Pro  Pro Pro Gly 
    1160                 1165                 1170             


Ala Pro  Asp Lys Asp Lys Gln  Lys Gln Glu Pro Lys  Thr Pro Val 
    1175                 1180                 1185             


Ala Pro  Lys Lys Asp Leu Lys  Ile Lys Asn Met Gly  Ser Trp Ala 
    1190                 1195                 1200             


Ser Leu  Val Gln Lys His Pro  Thr Thr Pro Ser Ser  Thr Ala Lys 
    1205                 1210                 1215             


Ser Ser  Ser Asp Ser Phe Glu  Gln Phe Arg Arg Ala  Ala Arg Glu 
    1220                 1225                 1230             


Lys Glu  Glu Arg Glu Lys Ala  Leu Lys Ala Gln Ala  Glu His Ala 
    1235                 1240                 1245             


Glu Lys  Glu Lys Glu Arg Leu  Arg Gln Glu Arg Met  Arg Ser Arg 
    1250                 1255                 1260             


Glu Asp  Glu Asp Ala Leu Glu  Gln Ala Arg Arg Ala  His Glu Glu 
    1265                 1270                 1275             


Ala Arg  Arg Arg Gln Glu Gln  Gln Gln Gln Gln Arg  Gln Glu Gln 
    1280                 1285                 1290             


Gln Gln  Gln Gln Gln Gln Gln  Ala Ala Ala Val Ala  Ala Ala Ala 
    1295                 1300                 1305             


Thr Pro  Gln Ala Gln Ser Ser  Gln Pro Gln Ser Met  Leu Asp Gln 
    1310                 1315                 1320             


Gln Arg  Glu Leu Ala Arg Lys  Arg Glu Gln Glu Arg  Arg Arg Arg 
    1325                 1330                 1335             


Glu Ala  Met Ala Ala Thr Ile  Asp Met Asn Phe Gln  Ser Asp Leu 
    1340                 1345                 1350             


Leu Ser  Ile Phe Glu Glu Asn  Leu Phe 
    1355                 1360         


<210>  18
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Tyr Asp Asp Ser Tyr Val Pro Gly Phe Glu Asp Ser Glu Ala Gly 
1               5                   10                  15      


Ser Ala Asp Ser Tyr Thr Ser Arg Pro Ser Leu Asp Ser Asp Val Ser 
            20                  25                  30          


Leu Glu Glu Asp Arg Glu Ser Ala Arg Arg Glu Val Glu Ser Gln Ala 
        35                  40                  45              


Gln Gln Gln Leu Glu Arg Ala Lys His Lys Pro Val Ala Phe Ala Val 
    50                  55                  60                  


Arg Thr Asn Val Ser Tyr Cys Gly Val Leu Asp Glu Glu Cys Pro Val 
65                  70                  75                  80  


Gln Gly Ser Gly Val Asn Phe Glu Ala Lys Asp Phe Leu His Ile Lys 
                85                  90                  95      


Glu Lys Tyr Ser Asn Asp Trp Trp Ile Gly Arg Leu Val Lys Glu Gly 
            100                 105                 110         


Gly Asp Ile Ala Phe Ile Pro Ser Pro Gln Arg Leu Glu Ser Ile Arg 
        115                 120                 125             


Leu Lys Gln Glu Gln Lys Ala Arg Arg Ser Gly Asn Pro Ser Ser Leu 
    130                 135                 140                 


Ser Asp Ile Gly Asn Arg Arg Ser Pro Pro Pro Ser Leu Ala Lys Gln 
145                 150                 155                 160 


Lys Gln Lys Gln Ala Glu His Val Pro Pro Tyr Asp Val Val Pro Ser 
                165                 170                 175     


Met Arg Pro Val Val Leu Val Gly Pro Ser Leu Lys Gly Tyr Glu Val 
            180                 185                 190         


Thr Asp Met Met Gln Lys Ala Leu Phe Asp Phe Leu Lys His Arg Phe 
        195                 200                 205             


Asp Gly Arg Ile Ser Ile Thr Arg Val Thr Ala Asp Leu Ser Leu Ala 
    210                 215                 220                 


Lys Arg Ser Val Leu Asn Asn Pro Gly Lys Arg Thr Ile Ile Glu Arg 
225                 230                 235                 240 


Ser Ser Ala Arg Ser Ser Ile Ala Glu Val Gln Ser Glu Ile Glu Arg 
                245                 250                 255     


Ile Phe Glu Leu Ala Lys Ser Leu Gln Leu Val Val Leu Asp Ala Asp 
            260                 265                 270         


Thr Ile Asn His Pro Ala Gln Leu Ala Lys Thr Ser Leu Ala Pro Ile 
        275                 280                 285             


Ile Val Phe Val Lys Val Ser Ser Pro Lys Val Leu Gln Arg Leu Ile 
    290                 295                 300                 


Arg Ser Arg Gly Lys Ser Gln Met Lys His Leu Thr Val Gln Met Met 
305                 310                 315                 320 


Ala Tyr Asp Lys Leu Val Gln Cys Pro Pro Glu Ser Phe Asp Val Ile 
                325                 330                 335     


Leu Asp Glu Asn Gln Leu Glu Asp Ala Cys Glu His Leu Ala Glu Tyr 
            340                 345                 350         


Leu Glu Val Tyr Trp Arg Ala Thr His His Pro Ala Pro Gly Pro Gly 
        355                 360                 365             


Leu Leu Gly Pro Pro Ser Ala Ile Pro Gly Leu Gln Asn Gln Gln Leu 
    370                 375                 380                 


Leu Gly Glu Arg Gly Glu Glu His Ser Pro Leu Glu Arg Asp Ser Leu 
385                 390                 395                 400 


Met Pro Ser Asp Glu Ala Ser Glu Ser Ser Arg Gln Ala Trp Thr Gly 
                405                 410                 415     


Ser Ser Gln Arg Ser Ser Arg His Leu Glu Glu Asp Tyr Ala Asp Ala 
            420                 425                 430         


Tyr Gln Asp Leu Tyr Gln Pro His Arg Gln His Thr Ser Gly Leu Pro 
        435                 440                 445             


Ser Ala Asn Gly His Asp Pro Gln Asp Arg Leu Leu Ala Gln Asp Ser 
    450                 455                 460                 


Glu His Asn His Ser Asp Arg Asn Trp Gln Arg Asn Arg Pro Trp Pro 
465                 470                 475                 480 


Lys Asp Ser Tyr 
                


<210>  19
<211>  2225
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ala Leu Val Leu Glu Asp Gly Ser Val Leu Arg Gly Gln Pro 
1               5                   10                  15      


Phe Gly Ala Ala Val Ser Thr Ala Gly Glu Val Val Phe Gln Thr Gly 
            20                  25                  30          


Met Val Gly Tyr Pro Glu Ala Leu Thr Asp Pro Ser Tyr Lys Ala Gln 
        35                  40                  45              


Ile Leu Val Leu Thr Tyr Pro Leu Ile Gly Asn Tyr Gly Ile Pro Pro 
    50                  55                  60                  


Asp Glu Met Asp Glu Phe Gly Leu Cys Lys Trp Phe Glu Ser Ser Gly 
65                  70                  75                  80  


Ile His Val Ala Ala Leu Val Val Gly Glu Cys Cys Pro Thr Pro Ser 
                85                  90                  95      


His Trp Ser Ala Thr Arg Thr Leu His Glu Trp Leu Gln Gln His Gly 
            100                 105                 110         


Ile Pro Gly Leu Gln Gly Val Asp Thr Arg Glu Leu Thr Lys Lys Leu 
        115                 120                 125             


Arg Glu Gln Gly Ser Leu Leu Gly Lys Leu Val Gln Asn Gly Thr Glu 
    130                 135                 140                 


Pro Ser Ser Leu Pro Phe Leu Asp Pro Asn Ala Arg Pro Leu Val Pro 
145                 150                 155                 160 


Glu Val Ser Ile Lys Thr Pro Arg Val Phe Asn Thr Gly Gly Ala Pro 
                165                 170                 175     


Arg Ile Leu Ala Leu Asp Cys Gly Leu Lys Tyr Asn Gln Ile Arg Cys 
            180                 185                 190         


Leu Cys Gln Arg Gly Ala Glu Val Thr Val Val Pro Trp Asp His Ala 
        195                 200                 205             


Leu Asp Ser Gln Glu Tyr Glu Gly Leu Phe Leu Ser Asn Gly Pro Gly 
    210                 215                 220                 


Asp Pro Ala Ser Tyr Pro Ser Val Val Ser Thr Leu Ser Arg Val Leu 
225                 230                 235                 240 


Ser Glu Pro Asn Pro Arg Pro Val Phe Gly Ile Cys Leu Gly His Gln 
                245                 250                 255     


Leu Leu Ala Leu Ala Ile Gly Ala Lys Thr Tyr Lys Met Arg Tyr Gly 
            260                 265                 270         


Asn Arg Gly His Asn Gln Pro Cys Leu Leu Val Gly Ser Gly Arg Cys 
        275                 280                 285             


Phe Leu Thr Ser Gln Asn His Gly Phe Ala Val Glu Thr Asp Ser Leu 
    290                 295                 300                 


Pro Ala Asp Trp Ala Pro Leu Phe Thr Asn Ala Asn Asp Gly Ser Asn 
305                 310                 315                 320 


Glu Gly Ile Val His Asn Ser Leu Pro Phe Phe Ser Val Gln Phe His 
                325                 330                 335     


Pro Glu His Gln Ala Gly Pro Ser Asp Met Glu Leu Leu Phe Asp Ile 
            340                 345                 350         


Phe Leu Glu Thr Val Lys Glu Ala Thr Ala Gly Asn Pro Gly Gly Gln 
        355                 360                 365             


Thr Val Arg Glu Arg Leu Thr Glu Arg Leu Cys Pro Pro Gly Ile Pro 
    370                 375                 380                 


Thr Pro Gly Ser Gly Leu Pro Pro Pro Arg Lys Val Leu Ile Leu Gly 
385                 390                 395                 400 


Ser Gly Gly Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly 
                405                 410                 415     


Ser Gln Ala Ile Lys Ala Leu Lys Glu Glu Asn Ile Gln Thr Leu Leu 
            420                 425                 430         


Ile Asn Pro Asn Ile Ala Thr Val Gln Thr Ser Gln Gly Leu Ala Asp 
        435                 440                 445             


Lys Val Tyr Phe Leu Pro Ile Thr Pro His Tyr Val Thr Gln Val Ile 
    450                 455                 460                 


Arg Asn Glu Arg Pro Asp Gly Val Leu Leu Thr Phe Gly Gly Gln Thr 
465                 470                 475                 480 


Ala Leu Asn Cys Gly Val Glu Leu Thr Lys Ala Gly Val Leu Ala Arg 
                485                 490                 495     


Tyr Gly Val Arg Val Leu Gly Thr Pro Val Glu Thr Ile Glu Leu Thr 
            500                 505                 510         


Glu Asp Arg Arg Ala Phe Ala Ala Arg Met Ala Glu Ile Gly Glu His 
        515                 520                 525             


Val Ala Pro Ser Glu Ala Ala Asn Ser Leu Glu Gln Ala Gln Ala Ala 
    530                 535                 540                 


Ala Glu Arg Leu Gly Tyr Pro Val Leu Val Arg Ala Ala Phe Ala Leu 
545                 550                 555                 560 


Gly Gly Leu Gly Ser Gly Phe Ala Ser Asn Arg Glu Glu Leu Ser Ala 
                565                 570                 575     


Leu Val Ala Pro Ala Phe Ala His Thr Ser Gln Val Leu Val Asp Lys 
            580                 585                 590         


Ser Leu Lys Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
        595                 600                 605             


Tyr Gly Asn Cys Val Thr Val Cys Asn Met Glu Asn Leu Asp Pro Leu 
    610                 615                 620                 


Gly Ile His Thr Gly Glu Ser Ile Val Val Ala Pro Ser Gln Thr Leu 
625                 630                 635                 640 


Asn Asp Arg Glu Tyr Gln Leu Leu Arg Gln Thr Ala Ile Lys Val Thr 
                645                 650                 655     


Gln His Leu Gly Ile Val Gly Glu Cys Asn Val Gln Tyr Ala Leu Asn 
            660                 665                 670         


Pro Glu Ser Glu Gln Tyr Tyr Ile Ile Glu Val Asn Ala Arg Leu Ser 
        675                 680                 685             


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Tyr 
    690                 695                 700                 


Val Ala Ala Lys Leu Ala Leu Gly Ile Pro Leu Pro Glu Leu Arg Asn 
705                 710                 715                 720 


Ser Val Thr Gly Gly Thr Ala Ala Phe Glu Pro Ser Val Asp Tyr Cys 
                725                 730                 735     


Val Val Lys Ile Pro Arg Trp Asp Leu Ser Lys Phe Leu Arg Val Ser 
            740                 745                 750         


Thr Lys Ile Gly Ser Cys Met Lys Ser Val Gly Glu Val Met Gly Ile 
        755                 760                 765             


Gly Arg Ser Phe Glu Glu Ala Phe Gln Lys Ala Leu Arg Met Val Asp 
    770                 775                 780                 


Glu Asn Cys Val Gly Phe Asp His Thr Val Lys Pro Val Ser Asp Met 
785                 790                 795                 800 


Glu Leu Glu Thr Pro Thr Asp Lys Arg Ile Phe Val Val Ala Ala Ala 
                805                 810                 815     


Leu Trp Ala Gly Tyr Ser Val Asp Arg Leu Tyr Glu Leu Thr Arg Ile 
            820                 825                 830         


Asp Arg Trp Phe Leu His Arg Met Lys Arg Ile Ile Ala His Ala Gln 
        835                 840                 845             


Leu Leu Glu Gln His Arg Gly Gln Pro Leu Pro Pro Asp Leu Leu Gln 
    850                 855                 860                 


Gln Ala Lys Cys Leu Gly Phe Ser Asp Lys Gln Ile Ala Leu Ala Val 
865                 870                 875                 880 


Leu Ser Thr Glu Leu Ala Val Arg Lys Leu Arg Gln Glu Leu Gly Ile 
                885                 890                 895     


Cys Pro Ala Val Lys Gln Ile Asp Thr Val Ala Ala Glu Trp Pro Ala 
            900                 905                 910         


Gln Thr Asn Tyr Leu Tyr Leu Thr Tyr Trp Gly Thr Thr His Asp Leu 
        915                 920                 925             


Thr Phe Arg Thr Pro His Val Leu Val Leu Gly Ser Gly Val Tyr Arg 
    930                 935                 940                 


Ile Gly Ser Ser Val Glu Phe Asp Trp Cys Ala Val Gly Cys Ile Gln 
945                 950                 955                 960 


Gln Leu Arg Lys Met Gly Tyr Lys Thr Ile Met Val Asn Tyr Asn Pro 
                965                 970                 975     


Glu Thr Val Ser Thr Asp Tyr Asp Met Cys Asp Arg Leu Tyr Phe Asp 
            980                 985                 990         


Glu Ile Ser Phe Glu Val Val Met  Asp Ile Tyr Glu Leu  Glu Asn Pro 
        995                 1000                 1005             


Glu Gly  Val Ile Leu Ser Met  Gly Gly Gln Leu Pro  Asn Asn Met 
    1010                 1015                 1020             


Ala Met  Ala Leu His Arg Gln  Gln Cys Arg Val Leu  Gly Thr Ser 
    1025                 1030                 1035             


Pro Glu  Ala Ile Asp Ser Ala  Glu Asn Arg Phe Lys  Phe Ser Arg 
    1040                 1045                 1050             


Leu Leu  Asp Thr Ile Gly Ile  Ser Gln Pro Gln Trp  Arg Glu Leu 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ala Arg  Gln Phe Cys Gln Thr  Val Gly Tyr 
    1070                 1075                 1080             


Pro Cys  Val Val Arg Pro Ser  Tyr Val Leu Ser Gly  Ala Ala Met 
    1085                 1090                 1095             


Asn Val  Ala Tyr Thr Asp Gly  Asp Leu Glu Arg Phe  Leu Ser Ser 
    1100                 1105                 1110             


Ala Ala  Ala Val Ser Lys Glu  His Pro Val Val Ile  Ser Lys Phe 
    1115                 1120                 1125             


Ile Gln  Glu Ala Lys Glu Ile  Asp Val Asp Ala Val  Ala Ser Asp 
    1130                 1135                 1140             


Gly Val  Val Ala Ala Ile Ala  Ile Ser Glu His Val  Glu Asn Ala 
    1145                 1150                 1155             


Gly Val  His Ser Gly Asp Ala  Thr Leu Val Thr Pro  Pro Gln Asp 
    1160                 1165                 1170             


Ile Thr  Ala Lys Thr Leu Glu  Arg Ile Lys Ala Ile  Val His Ala 
    1175                 1180                 1185             


Val Gly  Gln Glu Leu Gln Val  Thr Gly Pro Phe Asn  Leu Gln Leu 
    1190                 1195                 1200             


Ile Ala  Lys Asp Asp Gln Leu  Lys Val Ile Glu Cys  Asn Val Arg 
    1205                 1210                 1215             


Val Ser  Arg Ser Phe Pro Phe  Val Ser Lys Thr Leu  Gly Val Asp 
    1220                 1225                 1230             


Leu Val  Ala Leu Ala Thr Arg  Val Ile Met Gly Glu  Glu Val Glu 
    1235                 1240                 1245             


Pro Val  Gly Leu Met Thr Gly  Ser Gly Val Val Gly  Val Lys Val 
    1250                 1255                 1260             


Pro Gln  Phe Ser Phe Ser Arg  Leu Ala Gly Ala Asp  Val Val Leu 
    1265                 1270                 1275             


Gly Val  Glu Met Thr Ser Thr  Gly Glu Val Ala Gly  Phe Gly Glu 
    1280                 1285                 1290             


Ser Arg  Cys Glu Ala Tyr Leu  Lys Ala Met Leu Ser  Thr Gly Phe 
    1295                 1300                 1305             


Lys Ile  Pro Lys Lys Asn Ile  Leu Leu Thr Ile Gly  Ser Tyr Lys 
    1310                 1315                 1320             


Asn Lys  Ser Glu Leu Leu Pro  Thr Val Arg Leu Leu  Glu Ser Leu 
    1325                 1330                 1335             


Gly Tyr  Ser Leu Tyr Ala Ser  Leu Gly Thr Ala Asp  Phe Tyr Thr 
    1340                 1345                 1350             


Glu His  Gly Val Lys Val Thr  Ala Val Asp Trp His  Phe Glu Glu 
    1355                 1360                 1365             


Ala Val  Asp Gly Glu Cys Pro  Pro Gln Arg Ser Ile  Leu Glu Gln 
    1370                 1375                 1380             


Leu Ala  Glu Lys Asn Phe Glu  Leu Val Ile Asn Leu  Ser Met Arg 
    1385                 1390                 1395             


Gly Ala  Gly Gly Arg Arg Leu  Ser Ser Phe Val Thr  Lys Gly Tyr 
    1400                 1405                 1410             


Arg Thr  Arg Arg Leu Ala Ala  Asp Phe Ser Val Pro  Leu Ile Ile 
    1415                 1420                 1425             


Asp Ile  Lys Cys Thr Lys Leu  Phe Val Glu Ala Leu  Gly Gln Ile 
    1430                 1435                 1440             


Gly Pro  Ala Pro Pro Leu Lys  Val His Val Asp Cys  Met Thr Ser 
    1445                 1450                 1455             


Gln Lys  Leu Val Arg Leu Pro  Gly Leu Ile Asp Val  His Val His 
    1460                 1465                 1470             


Leu Arg  Glu Pro Gly Gly Thr  His Lys Glu Asp Phe  Ala Ser Gly 
    1475                 1480                 1485             


Thr Ala  Ala Ala Leu Ala Gly  Gly Ile Thr Met Val  Cys Ala Met 
    1490                 1495                 1500             


Pro Asn  Thr Arg Pro Pro Ile  Ile Asp Ala Pro Ala  Leu Ala Leu 
    1505                 1510                 1515             


Ala Gln  Lys Leu Ala Glu Ala  Gly Ala Arg Cys Asp  Phe Ala Leu 
    1520                 1525                 1530             


Phe Leu  Gly Ala Ser Ser Glu  Asn Ala Gly Thr Leu  Gly Thr Val 
    1535                 1540                 1545             


Ala Gly  Ser Ala Ala Gly Leu  Lys Leu Tyr Leu Asn  Glu Thr Phe 
    1550                 1555                 1560             


Ser Glu  Leu Arg Leu Asp Ser  Val Val Gln Trp Met  Glu His Phe 
    1565                 1570                 1575             


Glu Thr  Trp Pro Ser His Leu  Pro Ile Val Ala His  Ala Glu Gln 
    1580                 1585                 1590             


Gln Thr  Val Ala Ala Val Leu  Met Val Ala Gln Leu  Thr Gln Arg 
    1595                 1600                 1605             


Ser Val  His Ile Cys His Val  Ala Arg Lys Glu Glu  Ile Leu Leu 
    1610                 1615                 1620             


Ile Lys  Ala Ala Lys Ala Arg  Gly Leu Pro Val Thr  Cys Glu Val 
    1625                 1630                 1635             


Ala Pro  His His Leu Phe Leu  Ser His Asp Asp Leu  Glu Arg Leu 
    1640                 1645                 1650             


Gly Pro  Gly Lys Gly Glu Val  Arg Pro Glu Leu Gly  Ser Arg Gln 
    1655                 1660                 1665             


Asp Val  Glu Ala Leu Trp Glu  Asn Met Ala Val Ile  Asp Cys Phe 
    1670                 1675                 1680             


Ala Ser  Asp His Ala Pro His  Thr Leu Glu Glu Lys  Cys Gly Ser 
    1685                 1690                 1695             


Arg Pro  Pro Pro Gly Phe Pro  Gly Leu Glu Thr Met  Leu Pro Leu 
    1700                 1705                 1710             


Leu Leu  Thr Ala Val Ser Glu  Gly Arg Leu Ser Leu  Asp Asp Leu 
    1715                 1720                 1725             


Leu Gln  Arg Leu His His Asn  Pro Arg Arg Ile Phe  His Leu Pro 
    1730                 1735                 1740             


Pro Gln  Glu Asp Thr Tyr Val  Glu Val Asp Leu Glu  His Glu Trp 
    1745                 1750                 1755             


Thr Ile  Pro Ser His Met Pro  Phe Ser Lys Ala His  Trp Thr Pro 
    1760                 1765                 1770             


Phe Glu  Gly Gln Lys Val Lys  Gly Thr Val Arg Arg  Val Val Leu 
    1775                 1780                 1785             


Arg Gly  Glu Val Ala Tyr Ile  Asp Gly Gln Val Leu  Val Pro Pro 
    1790                 1795                 1800             


Gly Tyr  Gly Gln Asp Val Arg  Lys Trp Pro Gln Gly  Ala Val Pro 
    1805                 1810                 1815             


Gln Leu  Pro Pro Ser Ala Pro  Ala Thr Ser Glu Met  Thr Thr Thr 
    1820                 1825                 1830             


Pro Glu  Arg Pro Arg Arg Gly  Ile Pro Gly Leu Pro  Asp Gly Arg 
    1835                 1840                 1845             


Phe His  Leu Pro Pro Arg Ile  His Arg Ala Ser Asp  Pro Gly Leu 
    1850                 1855                 1860             


Pro Ala  Glu Glu Pro Lys Glu  Lys Ser Ser Arg Lys  Val Ala Glu 
    1865                 1870                 1875             


Pro Glu  Leu Met Gly Thr Pro  Asp Gly Thr Cys Tyr  Pro Pro Pro 
    1880                 1885                 1890             


Pro Val  Pro Arg Gln Ala Ser  Pro Gln Asn Leu Gly  Thr Pro Gly 
    1895                 1900                 1905             


Leu Leu  His Pro Gln Thr Ser  Pro Leu Leu His Ser  Leu Val Gly 
    1910                 1915                 1920             


Gln His  Ile Leu Ser Val Gln  Gln Phe Thr Lys Asp  Gln Met Ser 
    1925                 1930                 1935             


His Leu  Phe Asn Val Ala His  Thr Leu Arg Met Met  Val Gln Lys 
    1940                 1945                 1950             


Glu Arg  Ser Leu Asp Ile Leu  Lys Gly Lys Val Met  Ala Ser Met 
    1955                 1960                 1965             


Phe Tyr  Glu Val Ser Thr Arg  Thr Ser Ser Ser Phe  Ala Ala Ala 
    1970                 1975                 1980             


Met Ala  Arg Leu Gly Gly Ala  Val Leu Ser Phe Ser  Glu Ala Thr 
    1985                 1990                 1995             


Ser Ser  Val Gln Lys Gly Glu  Ser Leu Ala Asp Ser  Val Gln Thr 
    2000                 2005                 2010             


Met Ser  Cys Tyr Ala Asp Val  Val Val Leu Arg His  Pro Gln Pro 
    2015                 2020                 2025             


Gly Ala  Val Glu Leu Ala Ala  Lys His Cys Arg Arg  Pro Val Ile 
    2030                 2035                 2040             


Asn Ala  Gly Asp Gly Val Gly  Glu His Pro Thr Gln  Ala Leu Leu 
    2045                 2050                 2055             


Asp Ile  Phe Thr Ile Arg Glu  Glu Leu Gly Thr Val  Asn Gly Met 
    2060                 2065                 2070             


Thr Ile  Thr Met Val Gly Asp  Leu Lys His Gly Arg  Thr Val His 
    2075                 2080                 2085             


Ser Leu  Ala Cys Leu Leu Thr  Gln Tyr Arg Val Ser  Leu Arg Tyr 
    2090                 2095                 2100             


Val Ala  Pro Pro Ser Leu Arg  Met Pro Pro Thr Val  Arg Ala Phe 
    2105                 2110                 2115             


Val Ala  Ser Arg Gly Thr Lys  Gln Glu Glu Phe Glu  Ser Ile Glu 
    2120                 2125                 2130             


Glu Ala  Leu Pro Asp Thr Asp  Val Leu Tyr Met Thr  Arg Ile Gln 
    2135                 2140                 2145             


Lys Glu  Arg Phe Gly Ser Thr  Gln Glu Tyr Glu Ala  Cys Phe Gly 
    2150                 2155                 2160             


Gln Phe  Ile Leu Thr Pro His  Ile Met Thr Arg Ala  Lys Lys Lys 
    2165                 2170                 2175             


Met Val  Val Met His Pro Met  Pro Arg Val Asn Glu  Ile Ser Val 
    2180                 2185                 2190             


Glu Val  Asp Ser Asp Pro Arg  Ala Ala Tyr Phe Arg  Gln Ala Glu 
    2195                 2200                 2205             


Asn Gly  Met Tyr Ile Arg Met  Ala Leu Leu Ala Thr  Val Leu Gly 
    2210                 2215                 2220             


Arg Phe  
    2225 


<210>  20
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Gly Asn Ser Ala Pro Gly Pro Ala Thr Arg Glu Ala Gly Ser 
1               5                   10                  15      


Ala Leu Leu Ala Leu Gln Gln Thr Ala Leu Gln Glu Asp Gln Glu Asn 
            20                  25                  30          


Ile Asn Pro Glu Lys Ala Ala Pro Val Gln Gln Pro Arg Thr Arg Ala 
        35                  40                  45              


Ala Leu Ala Val Leu Lys Ser Gly Asn Pro Arg Gly Leu Ala Gln Gln 
    50                  55                  60                  


Gln Arg Pro Lys Thr Arg Arg Val Ala Pro Leu Lys Asp Leu Pro Val 
65                  70                  75                  80  


Asn Asp Glu His Val Thr Val Pro Pro Trp Lys Ala Asn Ser Lys Gln 
                85                  90                  95      


Pro Ala Phe Thr Ile His Val Asp Glu Ala Glu Lys Glu Ala Gln Lys 
            100                 105                 110         


Lys Pro Ala Glu Ser Gln Lys Ile Glu Arg Glu Asp Ala Leu Ala Phe 
        115                 120                 125             


Asn Ser Ala Ile Ser Leu Pro Gly Pro Arg Lys Pro Leu Val Pro Leu 
    130                 135                 140                 


Asp Tyr Pro Met Asp Gly Ser Phe Glu Ser Pro His Thr Met Asp Met 
145                 150                 155                 160 


Ser Ile Ile Leu Glu Asp Glu Lys Pro Val Ser Val Asn Glu Val Pro 
                165                 170                 175     


Asp Tyr His Glu Asp Ile His Thr Tyr Leu Arg Glu Met Glu Val Lys 
            180                 185                 190         


Cys Lys Pro Lys Val Gly Tyr Met Lys Lys Gln Pro Asp Ile Thr Asn 
        195                 200                 205             


Ser Met Arg Ala Ile Leu Val Asp Trp Leu Val Glu Val Gly Glu Glu 
    210                 215                 220                 


Tyr Lys Leu Gln Asn Glu Thr Leu His Leu Ala Val Asn Tyr Ile Asp 
225                 230                 235                 240 


Arg Phe Leu Ser Ser Met Ser Val Leu Arg Gly Lys Leu Gln Leu Val 
                245                 250                 255     


Gly Thr Ala Ala Met Leu Leu Ala Ser Lys Phe Glu Glu Ile Tyr Pro 
            260                 265                 270         


Pro Glu Val Ala Glu Phe Val Tyr Ile Thr Asp Asp Thr Tyr Thr Lys 
        275                 280                 285             


Lys Gln Val Leu Arg Met Glu His Leu Val Leu Lys Val Leu Thr Phe 
    290                 295                 300                 


Asp Leu Ala Ala Pro Thr Val Asn Gln Phe Leu Thr Gln Tyr Phe Leu 
305                 310                 315                 320 


His Gln Gln Pro Ala Asn Cys Lys Val Glu Ser Leu Ala Met Phe Leu 
                325                 330                 335     


Gly Glu Leu Ser Leu Ile Asp Ala Asp Pro Tyr Leu Lys Tyr Leu Pro 
            340                 345                 350         


Ser Val Ile Ala Gly Ala Ala Phe His Leu Ala Leu Tyr Thr Val Thr 
        355                 360                 365             


Gly Gln Ser Trp Pro Glu Ser Leu Ile Arg Lys Thr Gly Tyr Thr Leu 
    370                 375                 380                 


Glu Ser Leu Lys Pro Cys Leu Met Asp Leu His Gln Thr Tyr Leu Lys 
385                 390                 395                 400 


Ala Pro Gln His Ala Gln Gln Ser Ile Arg Glu Lys Tyr Lys Asn Ser 
                405                 410                 415     


Lys Tyr His Gly Val Ser Leu Leu Asn Pro Pro Glu Thr Leu Asn Leu 
            420                 425                 430         


<210>  21
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  22
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Ser Ala Lys Ser Val Pro Val Thr Pro Ala Arg Pro Pro Pro 
1               5                   10                  15      


His Asn Lys His Leu Ala Arg Val Ala Asp Pro Arg Ser Pro Ser Ala 
            20                  25                  30          


Gly Ile Leu Arg Thr Pro Ile Gln Val Glu Ser Ser Pro Gln Pro Gly 
        35                  40                  45              


Leu Pro Ala Gly Glu Gln Leu Glu Gly Leu Lys His Ala Gln Asp Ser 
    50                  55                  60                  


Asp Pro Arg Ser Pro Thr Leu Gly Ile Ala Arg Thr Pro Met Lys Thr 
65                  70                  75                  80  


Ser Ser Gly Asp Pro Pro Ser Pro Leu Val Lys Gln Leu Ser Glu Val 
                85                  90                  95      


Phe Glu Thr Glu Asp Ser Lys Ser Asn Leu Pro Pro Glu Pro Val Leu 
            100                 105                 110         


Pro Pro Glu Ala Pro Leu Ser Ser Glu Leu Asp Leu Pro Leu Gly Thr 
        115                 120                 125             


Gln Leu Ser Val Glu Glu Gln Met Pro Pro Trp Asn Gln Thr Glu Phe 
    130                 135                 140                 


Pro Ser Lys Gln Val Phe Ser Lys Glu Glu Ala Arg Gln Pro Thr Glu 
145                 150                 155                 160 


Thr Pro Val Ala Ser Gln Ser Ser Asp Lys Pro Ser Arg Asp Pro Glu 
                165                 170                 175     


Thr Pro Arg Ser Ser Gly Ser Met Arg Asn Arg Trp Lys Pro Asn Ser 
            180                 185                 190         


Ser Lys Val Leu Gly Arg Ser Pro Leu Thr Ile Leu Gln Asp Asp Asn 
        195                 200                 205             


Ser Pro Gly Thr Leu Thr Leu Arg Gln Gly Lys Arg Pro Ser Pro Leu 
    210                 215                 220                 


Ser Glu Asn Val Ser Glu Leu Lys Glu Gly Ala Ile Leu Gly Thr Gly 
225                 230                 235                 240 


Arg Leu Leu Lys Thr Gly Gly Arg Ala Trp Glu Gln Gly Gln Asp His 
                245                 250                 255     


Asp Lys Glu Asn Gln His Phe Pro Leu Val Glu Ser 
            260                 265             


<210>  23
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Lys Gln Tyr Asp Ser Val Glu Cys Pro Phe Cys Asp Glu Val 
1               5                   10                  15      


Ser Lys Tyr Glu Lys Leu Ala Lys Ile Gly Gln Gly Thr Phe Gly Glu 
            20                  25                  30          


Val Phe Lys Ala Arg His Arg Lys Thr Gly Gln Lys Val Ala Leu Lys 
        35                  40                  45              


Lys Val Leu Met Glu Asn Glu Lys Glu Gly Phe Pro Ile Thr Ala Leu 
    50                  55                  60                  


Arg Glu Ile Lys Ile Leu Gln Leu Leu Lys His Glu Asn Val Val Asn 
65                  70                  75                  80  


Leu Ile Glu Ile Cys Arg Thr Lys Ala Ser Pro Tyr Asn Arg Cys Lys 
                85                  90                  95      


Gly Ser Ile Tyr Leu Val Phe Asp Phe Cys Glu His Asp Leu Ala Gly 
            100                 105                 110         


Leu Leu Ser Asn Val Leu Val Lys Phe Thr Leu Ser Glu Ile Lys Arg 
        115                 120                 125             


Val Met Gln Met Leu Leu Asn Gly Leu Tyr Tyr Ile His Arg Asn Lys 
    130                 135                 140                 


Ile Leu His Arg Asp Met Lys Ala Ala Asn Val Leu Ile Thr Arg Asp 
145                 150                 155                 160 


Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Arg Ala Phe Ser Leu 
                165                 170                 175     


Ala Lys Asn Ser Gln Pro Asn Arg Tyr Thr Asn Arg Val Val Thr Leu 
            180                 185                 190         


Trp Tyr Arg Pro Pro Glu Leu Leu Leu Gly Glu Arg Asp Tyr Gly Pro 
        195                 200                 205             


Pro Ile Asp Leu Trp Gly Ala Gly Cys Ile Met Ala Glu Met Trp Thr 
    210                 215                 220                 


Arg Ser Pro Ile Met Gln Gly Asn Thr Glu Gln His Gln Leu Ala Leu 
225                 230                 235                 240 


Ile Ser Gln Leu Cys Gly Ser Ile Thr Pro Glu Val Trp Pro Asn Val 
                245                 250                 255     


Asp Asn Tyr Glu Leu Tyr Glu Lys Leu Glu Leu Val Lys Gly Gln Lys 
            260                 265                 270         


Arg Lys Val Lys Asp Arg Leu Lys Ala Tyr Val Arg Asp Pro Tyr Ala 
        275                 280                 285             


Leu Asp Leu Ile Asp Lys Leu Leu Val Leu Asp Pro Ala Gln Arg Ile 
    290                 295                 300                 


Asp Ser Asp Asp Ala Leu Asn His Asp Phe Phe Trp Ser Asp Pro Met 
305                 310                 315                 320 


Pro Ser Asp Leu Lys Gly Met Leu Ser Thr His Leu Thr Ser Met Phe 
                325                 330                 335     


Glu Tyr Leu Ala Pro Pro Arg Arg Lys Gly Ser Gln Ile Thr Gln Gln 
            340                 345                 350         


Ser Thr Asn Gln Ser Arg Asn Pro Ala Thr Thr Asn Gln Thr Glu Phe 
        355                 360                 365             


Glu Arg Val Phe 
    370         


<210>  24
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Lys Pro Leu Val Val Phe Val Leu Gly Gly Pro Gly Ala Gly Lys 
1               5                   10                  15      


Gly Thr Gln Cys Ala Arg Ile Val Glu Lys Tyr Gly Tyr Thr His Leu 
            20                  25                  30          


Ser Ala Gly Glu Leu Leu Arg Asp Glu Arg Lys Asn Pro Asp Ser Gln 
        35                  40                  45              


Tyr Gly Glu Leu Ile Glu Lys Tyr Ile Lys Glu Gly Lys Ile Val Pro 
    50                  55                  60                  


Val Glu Ile Thr Ile Ser Leu Leu Lys Arg Glu Met Asp Gln Thr Met 
65                  70                  75                  80  


Ala Ala Asn Ala Gln Lys Asn Lys Phe Leu Ile Asp Gly Phe Pro Arg 
                85                  90                  95      


Asn Gln Asp Asn Leu Gln Gly Trp Asn Lys Thr Met Asp Gly Lys Ala 
            100                 105                 110         


Asp Val Ser Phe Val Leu Phe Phe Asp Cys Asn Asn Glu Ile Cys Ile 
        115                 120                 125             


Glu Arg Cys Leu Glu Arg Gly Lys Ser Ser Gly Arg Ser Asp Asp Asn 
    130                 135                 140                 


Arg Glu Ser Leu Glu Lys Arg Ile Gln Thr Tyr Leu Gln Ser Thr Lys 
145                 150                 155                 160 


Pro Ile Ile Asp Leu Tyr Glu Glu Met Gly Lys Val Lys Lys Ile Asp 
                165                 170                 175     


Ala Ser Lys Ser Val Asp Glu Val Phe Asp Glu Val Val Gln Ile Phe 
            180                 185                 190         


Asp Lys Glu Gly 
        195     


<210>  25
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Leu Gly Gln Ser Ile Arg Arg Phe Thr Thr Ser Val Val Arg Arg 
1               5                   10                  15      


Ser His Tyr Glu Glu Gly Pro Gly Lys Asn Leu Pro Phe Ser Val Glu 
            20                  25                  30          


Asn Lys Trp Ser Leu Leu Ala Lys Met Cys Leu Tyr Phe Gly Ser Ala 
        35                  40                  45              


Phe Ala Thr Pro Phe Leu Val Val Arg His Gln Leu Leu Lys Thr 
    50                  55                  60              


<210>  26
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  27
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Leu Leu Thr Ala Ala Ala Arg Leu Leu Gly Thr Lys Asn Ala 
1               5                   10                  15      


Ser Cys Leu Val Leu Ala Ala Arg His Ala Ser Ala Ser Ser Thr Asn 
            20                  25                  30          


Leu Lys Asp Ile Leu Ala Asp Leu Ile Pro Lys Glu Gln Ala Arg Ile 
        35                  40                  45              


Lys Thr Phe Arg Gln Gln His Gly Lys Thr Val Val Gly Gln Ile Thr 
    50                  55                  60                  


Val Asp Met Met Tyr Gly Gly Met Arg Gly Met Lys Gly Leu Val Tyr 
65                  70                  75                  80  


Glu Thr Ser Val Leu Asp Pro Asp Glu Gly Ile Arg Phe Arg Gly Phe 
                85                  90                  95      


Ser Ile Pro Glu Cys Gln Lys Leu Leu Pro Lys Ala Lys Gly Gly Glu 
            100                 105                 110         


Glu Pro Leu Pro Glu Gly Leu Phe Trp Leu Leu Val Thr Gly His Ile 
        115                 120                 125             


Pro Thr Glu Glu Gln Val Ser Trp Leu Ser Lys Glu Trp Ala Lys Arg 
    130                 135                 140                 


Ala Ala Leu Pro Ser His Val Val Thr Met Leu Asp Asn Phe Pro Thr 
145                 150                 155                 160 


Asn Leu His Pro Met Ser Gln Leu Ser Ala Ala Val Thr Ala Leu Asn 
                165                 170                 175     


Ser Glu Ser Asn Phe Ala Arg Ala Tyr Ala Gln Gly Ile Ser Arg Thr 
            180                 185                 190         


Lys Tyr Trp Glu Leu Ile Tyr Glu Asp Ser Met Asp Leu Ile Ala Lys 
        195                 200                 205             


Leu Pro Cys Val Ala Ala Lys Ile Tyr Arg Asn Leu Tyr Arg Glu Gly 
    210                 215                 220                 


Ser Gly Ile Gly Ala Ile Asp Ser Asn Leu Asp Trp Ser His Asn Phe 
225                 230                 235                 240 


Thr Asn Met Leu Gly Tyr Thr Asp His Gln Phe Thr Glu Leu Thr Arg 
                245                 250                 255     


Leu Tyr Leu Thr Ile His Ser Asp His Glu Gly Gly Asn Val Ser Ala 
            260                 265                 270         


His Thr Ser His Leu Val Gly Ser Ala Leu Ser Asp Pro Tyr Leu Ser 
        275                 280                 285             


Phe Ala Ala Ala Met Asn Gly Leu Ala Gly Pro Leu His Gly Leu Ala 
    290                 295                 300                 


Asn Gln Glu Val Leu Val Trp Leu Thr Gln Leu Gln Lys Glu Val Gly 
305                 310                 315                 320 


Lys Asp Val Ser Asp Glu Lys Leu Arg Asp Tyr Ile Trp Asn Thr Leu 
                325                 330                 335     


Asn Ser Gly Arg Val Val Pro Gly Tyr Gly His Ala Val Leu Arg Lys 
            340                 345                 350         


Thr Asp Pro Arg Tyr Thr Cys Gln Arg Glu Phe Ala Leu Lys His Leu 
        355                 360                 365             


Pro Asn Asp Pro Met Phe Lys Leu Val Ala Gln Leu Tyr Lys Ile Val 
    370                 375                 380                 


Pro Asn Val Leu Leu Glu Gln Gly Lys Ala Lys Asn Pro Trp Pro Asn 
385                 390                 395                 400 


Val Asp Ala His Ser Gly Val Leu Leu Gln Tyr Tyr Gly Met Thr Glu 
                405                 410                 415     


Met Asn Tyr Tyr Thr Val Leu Phe Gly Val Ser Arg Ala Leu Gly Val 
            420                 425                 430         


Leu Ala Gln Leu Ile Trp Ser Arg Ala Leu Gly Phe Pro Leu Glu Arg 
        435                 440                 445             


Pro Lys Ser Met Ser Thr Glu Gly Leu Met Lys Phe Val Asp Ser Lys 
    450                 455                 460                 


Ser Gly 
465     


<210>  28
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Tyr Phe Pro Ser Trp Leu Ser Gln Leu Tyr Arg Gly Leu Ser Arg 
1               5                   10                  15      


Pro Ile Arg Arg Thr Thr Gln Pro Ile Trp Gly Ser Leu Tyr Arg Ser 
            20                  25                  30          


Leu Leu Gln Ser Ser Gln Arg Arg Ile Pro Glu Phe Ser Ser Phe Val 
        35                  40                  45              


Val Arg Thr Asn Thr Cys Gly Glu Leu Arg Ser Ser His Leu Gly Gln 
    50                  55                  60                  


Glu Val Thr Leu Cys Gly Trp Ile Gln Tyr Arg Arg Gln Asn Thr Phe 
65                  70                  75                  80  


Leu Val Leu Arg Asp Phe Asp Gly Leu Val Gln Val Ile Ile Pro Gln 
                85                  90                  95      


Asp Glu Ser Ala Ala Ser Val Lys Lys Ile Leu Cys Glu Ala Pro Val 
            100                 105                 110         


Glu Ser Val Val Gln Val Ser Gly Thr Val Ile Ser Arg Pro Ala Gly 
        115                 120                 125             


Gln Glu Asn Pro Lys Met Pro Thr Gly Glu Ile Glu Ile Lys Val Lys 
    130                 135                 140                 


Thr Ala Glu Leu Leu Asn Ala Cys Lys Lys Leu Pro Phe Glu Ile Lys 
145                 150                 155                 160 


Asn Phe Val Lys Lys Thr Glu Ala Leu Arg Leu Gln Tyr Arg Tyr Leu 
                165                 170                 175     


Asp Leu Arg Ser Phe Gln Met Gln Tyr Asn Leu Arg Leu Arg Ser Gln 
            180                 185                 190         


Met Val Met Lys Met Arg Glu Tyr Leu Cys Asn Leu His Gly Phe Val 
        195                 200                 205             


Asp Ile Glu Thr Pro Thr Leu Phe Lys Arg Thr Pro Gly Gly Ala Lys 
    210                 215                 220                 


Glu Phe Leu Val Pro Ser Arg Glu Pro Gly Lys Phe Tyr Ser Leu Pro 
225                 230                 235                 240 


Gln Ser Pro Gln Gln Phe Lys Gln Leu Leu Met Val Gly Gly Leu Asp 
                245                 250                 255     


Arg Tyr Phe Gln Val Ala Arg Cys Tyr Arg Asp Glu Gly Ser Arg Pro 
            260                 265                 270         


Asp Arg Gln Pro Glu Phe Thr Gln Ile Asp Ile Glu Met Ser Phe Val 
        275                 280                 285             


Asp Gln Thr Gly Ile Gln Ser Leu Ile Glu Gly Leu Leu Gln Tyr Ser 
    290                 295                 300                 


Trp Pro Asn Asp Lys Asp Pro Val Val Val Pro Phe Pro Thr Met Thr 
305                 310                 315                 320 


Phe Ala Glu Val Leu Ala Thr Tyr Gly Thr Asp Lys Pro Asp Thr Arg 
                325                 330                 335     


Phe Gly Met Lys Ile Ile Asp Ile Ser Asp Val Phe Arg Asn Thr Glu 
            340                 345                 350         


Ile Gly Phe Leu Gln Asp Ala Leu Ser Lys Pro His Gly Thr Val Lys 
        355                 360                 365             


Ala Ile Cys Ile Pro Glu Gly Ala Lys Tyr Leu Lys Arg Lys Asp Ile 
    370                 375                 380                 


Glu Ser Ile Arg Asn Phe Ala Ala Asp His Phe Asn Gln Glu Ile Leu 
385                 390                 395                 400 


Pro Val Phe Leu Asn Ala Asn Arg Asn Trp Asn Ser Pro Val Ala Asn 
                405                 410                 415     


Phe Ile Met Glu Ser Gln Arg Leu Glu Leu Ile Arg Leu Met Glu Thr 
            420                 425                 430         


Gln Glu Glu Asp Val Val Leu Leu Thr Ala Gly Glu His Asn Lys Ala 
        435                 440                 445             


Cys Ser Leu Leu Gly Lys Leu Arg Leu Glu Cys Ala Asp Leu Leu Glu 
    450                 455                 460                 


Thr Arg Gly Val Val Leu Arg Asp Pro Thr Leu Phe Ser Phe Leu Trp 
465                 470                 475                 480 


Val Val Asp Phe Pro Leu Phe Leu Pro Lys Glu Glu Asn Pro Arg Glu 
                485                 490                 495     


Leu Glu Ser Ala His His Pro Phe Thr Ala Pro His Pro Ser Asp Ile 
            500                 505                 510         


His Leu Leu Tyr Thr Glu Pro Lys Lys Ala Arg Ser Gln His Tyr Asp 
        515                 520                 525             


Leu Val Leu Asn Gly Asn Glu Ile Gly Gly Gly Ser Ile Arg Ile His 
    530                 535                 540                 


Asn Ala Glu Leu Gln Arg Tyr Ile Leu Ala Thr Leu Leu Lys Glu Asp 
545                 550                 555                 560 


Val Lys Met Leu Ser His Leu Leu Gln Ala Leu Asp Tyr Gly Ala Pro 
                565                 570                 575     


Pro His Gly Gly Ile Ala Leu Gly Leu Asp Arg Leu Ile Cys Leu Val 
            580                 585                 590         


Thr Gly Ser Pro Ser Ile Arg Asp Val Ile Ala Phe Pro Lys Ser Phe 
        595                 600                 605             


Arg Gly His Asp Leu Met Ser Asn Thr Pro Asp Ser Val Pro Pro Glu 
    610                 615                 620                 


Glu Leu Lys Pro Tyr His Ile Arg Val Ser Lys Pro Thr Asp Ser Lys 
625                 630                 635                 640 


Ala Glu Arg Ala His 
                645 


<210>  29
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Asp Ala Ala Pro Gln Leu Gly Lys Arg Lys Arg Glu Leu Asp 
1               5                   10                  15      


Val Glu Glu Ala His Ala Ala Ser Thr Glu Glu Lys Glu Ala Gly Val 
            20                  25                  30          


Gly Asn Gly Thr Cys Ala Pro Val Arg Leu Pro Phe Ser Gly Phe Arg 
        35                  40                  45              


Leu Gln Lys Val Leu Arg Glu Ser Ala Arg Asp Lys Ile Ile Phe Leu 
    50                  55                  60                  


His Gly Lys Val Asn Glu Ala Ser Gly Asp Gly Asp Gly Glu Asp Ala 
65                  70                  75                  80  


Val Val Ile Leu Glu Lys Thr Pro Phe Gln Val Glu Gln Val Ala Gln 
                85                  90                  95      


Leu Leu Thr Gly Ser Pro Glu Leu Gln Leu Gln Phe Ser Asn Asp Ile 
            100                 105                 110         


Tyr Ser Thr Tyr His Leu Phe Pro Pro Arg Gln Leu Asn Asp Val Lys 
        115                 120                 125             


Thr Thr Val Val Tyr Pro Ala Thr Glu Lys His Leu Gln Lys Tyr Leu 
    130                 135                 140                 


Arg Gln Asp Leu Arg Leu Ile Arg Glu Thr Gly Asp Asp Tyr Arg Asn 
145                 150                 155                 160 


Ile Thr Leu Pro His Leu Glu Ser Gln Ser Leu Ser Ile Gln Trp Val 
                165                 170                 175     


Tyr Asn Ile Leu Asp Lys Lys Ala Glu Ala Asp Arg Ile Val Phe Glu 
            180                 185                 190         


Asn Pro Asp Pro Ser Asp Gly Phe Val Leu Ile Pro Asp Leu Lys Trp 
        195                 200                 205             


Asn Gln Gln Gln Leu Asp Asp Leu Tyr Leu Ile Ala Ile Cys His Arg 
    210                 215                 220                 


Arg Gly Ile Arg Ser Leu Arg Asp Leu Thr Pro Glu His Leu Pro Leu 
225                 230                 235                 240 


Leu Arg Asn Ile Leu His Gln Gly Gln Glu Ala Ile Leu Gln Arg Tyr 
                245                 250                 255     


Arg Met Lys Gly Asp His Leu Arg Val Tyr Leu His Tyr Leu Pro Ser 
            260                 265                 270         


Tyr Tyr His Leu His Val His Phe Thr Ala Leu Gly Phe Glu Ala Pro 
        275                 280                 285             


Gly Ser Gly Val Glu Arg Ala His Leu Leu Ala Glu Val Ile Glu Asn 
    290                 295                 300                 


Leu Glu Cys Asp Pro Arg His Tyr Gln Gln Arg Thr Leu Thr Phe Ala 
305                 310                 315                 320 


Leu Arg Ala Asp Asp Pro Leu Leu Lys Leu Leu Gln Glu Ala Gln Gln 
                325                 330                 335     


Ser 
    


<210>  30
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Trp Arg His Leu Lys Lys Arg Ala Gln Asp Ala Val Ile Ile 
1               5                   10                  15      


Leu Gly Gly Gly Gly Leu Leu Phe Ala Ser Tyr Leu Met Ala Thr Gly 
            20                  25                  30          


Asp Glu Arg Phe Tyr Ala Glu His Leu Met Pro Thr Leu Gln Gly Leu 
        35                  40                  45              


Leu Asp Pro Glu Ser Ala His Arg Leu Ala Val Arg Phe Thr Ser Leu 
    50                  55                  60                  


Gly Leu Leu Pro Arg Ala Arg Phe Gln Asp Ser Asp Met Leu Glu Val 
65                  70                  75                  80  


Arg Val Leu Gly His Lys Phe Arg Asn Pro Val Gly Ile Ala Ala Gly 
                85                  90                  95      


Phe Asp Lys His Gly Glu Ala Val Asp Gly Leu Tyr Lys Met Gly Phe 
            100                 105                 110         


Gly Phe Val Glu Ile Gly Ser Val Thr Pro Lys Pro Gln Glu Gly Asn 
        115                 120                 125             


Pro Arg Pro Arg Val Phe Arg Leu Pro Glu Asp Gln Ala Val Ile Asn 
    130                 135                 140                 


Arg Tyr Gly Phe Asn Ser His Gly Leu Ser Val Val Glu His Arg Leu 
145                 150                 155                 160 


Arg Ala Arg Gln Gln Lys Gln Ala Lys Leu Thr Glu Asp Gly Leu Pro 
                165                 170                 175     


Leu Gly Val Asn Leu Gly Lys Asn Lys Thr Ser Val Asp Ala Ala Glu 
            180                 185                 190         


Asp Tyr Ala Glu Gly Val Arg Val Leu Gly Pro Leu Ala Asp Tyr Leu 
        195                 200                 205             


Val Val Asn Val Ser Ser Pro Asn Thr Ala Gly Leu Arg Ser Leu Gln 
    210                 215                 220                 


Gly Lys Ala Glu Leu Arg Arg Leu Leu Thr Lys Val Leu Gln Glu Arg 
225                 230                 235                 240 


Asp Gly Leu Arg Arg Val His Arg Pro Ala Val Leu Val Lys Ile Ala 
                245                 250                 255     


Pro Asp Leu Thr Ser Gln Asp Lys Glu Asp Ile Ala Ser Val Val Lys 
            260                 265                 270         


Glu Leu Gly Ile Asp Gly Leu Ile Val Thr Asn Thr Thr Val Ser Arg 
        275                 280                 285             


Pro Ala Gly Leu Gln Gly Ala Leu Arg Ser Glu Thr Gly Gly Leu Ser 
    290                 295                 300                 


Gly Lys Pro Leu Arg Asp Leu Ser Thr Gln Thr Ile Arg Glu Met Tyr 
305                 310                 315                 320 


Ala Leu Thr Gln Gly Arg Val Pro Ile Ile Gly Val Gly Gly Val Ser 
                325                 330                 335     


Ser Gly Gln Asp Ala Leu Glu Lys Ile Arg Ala Gly Ala Ser Leu Val 
            340                 345                 350         


Gln Leu Tyr Thr Ala Leu Thr Phe Trp Gly Pro Pro Val Val Gly Lys 
        355                 360                 365             


Val Lys Arg Glu Leu Glu Ala Leu Leu Lys Glu Gln Gly Phe Gly Gly 
    370                 375                 380                 


Val Thr Asp Ala Ile Gly Ala Asp His Arg Arg 
385                 390                 395 


<210>  31
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gln Val Ala Met Asn Gly Lys Ala Arg Lys Glu Ala Val Gln Thr 
1               5                   10                  15      


Ala Ala Lys Glu Leu Leu Lys Phe Val Asn Arg Ser Pro Ser Pro Phe 
            20                  25                  30          


His Ala Val Ala Glu Cys Arg Asn Arg Leu Leu Gln Ala Gly Phe Ser 
        35                  40                  45              


Glu Leu Lys Glu Thr Glu Lys Trp Asn Ile Lys Pro Glu Ser Lys Tyr 
    50                  55                  60                  


Phe Met Thr Arg Asn Ser Ser Thr Ile Ile Ala Phe Ala Val Gly Gly 
65                  70                  75                  80  


Gln Tyr Val Pro Gly Asn Gly Phe Ser Leu Ile Gly Ala His Thr Asp 
                85                  90                  95      


Ser Pro Cys Leu Arg Val Lys Arg Arg Ser Arg Arg Ser Gln Val Gly 
            100                 105                 110         


Phe Gln Gln Val Gly Val Glu Thr Tyr Gly Gly Gly Ile Trp Ser Thr 
        115                 120                 125             


Trp Phe Asp Arg Asp Leu Thr Leu Ala Gly Arg Val Ile Val Lys Cys 
    130                 135                 140                 


Pro Thr Ser Gly Arg Leu Glu Gln Gln Leu Val His Val Glu Arg Pro 
145                 150                 155                 160 


Ile Leu Arg Ile Pro His Leu Ala Ile His Leu Gln Arg Asn Ile Asn 
                165                 170                 175     


Glu Asn Phe Gly Pro Asn Thr Glu Met His Leu Val Pro Ile Leu Ala 
            180                 185                 190         


Thr Ala Ile Gln Glu Glu Leu Glu Lys Gly Thr Pro Glu Pro Gly Pro 
        195                 200                 205             


Leu Asn Ala Val Asp Glu Arg His His Ser Val Leu Met Ser Leu Leu 
    210                 215                 220                 


Cys Ala His Leu Gly Leu Ser Pro Lys Asp Ile Val Glu Met Glu Leu 
225                 230                 235                 240 


Cys Leu Ala Asp Thr Gln Pro Ala Val Leu Gly Gly Ala Tyr Asp Glu 
                245                 250                 255     


Phe Ile Phe Ala Pro Arg Leu Asp Asn Leu His Ser Cys Phe Cys Ala 
            260                 265                 270         


Leu Gln Ala Leu Ile Asp Ser Cys Ala Gly Pro Gly Ser Leu Ala Thr 
        275                 280                 285             


Glu Pro His Val Arg Met Val Thr Leu Tyr Asp Asn Glu Glu Val Gly 
    290                 295                 300                 


Ser Glu Ser Ala Gln Gly Ala Gln Ser Leu Leu Thr Glu Leu Val Leu 
305                 310                 315                 320 


Arg Arg Ile Ser Ala Ser Cys Gln His Pro Thr Ala Phe Glu Glu Ala 
                325                 330                 335     


Ile Pro Lys Ser Phe Met Ile Ser Ala Asp Met Ala His Ala Val His 
            340                 345                 350         


Pro Asn Tyr Leu Asp Lys His Glu Glu Asn His Arg Pro Leu Phe His 
        355                 360                 365             


Lys Gly Pro Val Ile Lys Val Asn Ser Lys Gln Arg Tyr Ala Ser Asn 
    370                 375                 380                 


Ala Val Ser Glu Ala Leu Ile Arg Glu Val Ala Asn Lys Val Lys Val 
385                 390                 395                 400 


Pro Leu Gln Asp Leu Met Val Arg Asn Asp Thr Pro Cys Gly Thr Thr 
                405                 410                 415     


Ile Gly Pro Ile Leu Ala Ser Arg Leu Gly Leu Arg Val Leu Asp Leu 
            420                 425                 430         


Gly Ser Pro Gln Leu Ala Met His Ser Ile Arg Glu Met Ala Cys Thr 
        435                 440                 445             


Thr Gly Val Leu Gln Thr Leu Thr Leu Phe Lys Gly Phe Phe Glu Leu 
    450                 455                 460                 


Phe Pro Ser Leu Ser His Asn Leu Leu Val Asp 
465                 470                 475 


<210>  32
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ala Arg Arg Gly Ala Leu Ile Val Leu Glu Gly Val Asp Arg 
1               5                   10                  15      


Ala Gly Lys Ser Thr Gln Ser Arg Lys Leu Val Glu Ala Leu Cys Ala 
            20                  25                  30          


Ala Gly His Arg Ala Glu Leu Leu Arg Phe Pro Glu Arg Ser Thr Glu 
        35                  40                  45              


Ile Gly Lys Leu Leu Ser Ser Tyr Leu Gln Lys Lys Ser Asp Val Glu 
    50                  55                  60                  


Asp His Ser Val His Leu Leu Phe Ser Ala Asn Arg Trp Glu Gln Val 
65                  70                  75                  80  


Pro Leu Ile Lys Glu Lys Leu Ser Gln Gly Val Thr Leu Val Val Asp 
                85                  90                  95      


Arg Tyr Ala Phe Ser Gly Val Ala Phe Thr Gly Ala Lys Glu Asn Phe 
            100                 105                 110         


Ser Leu Asp Trp Cys Lys Gln Pro Asp Val Gly Leu Pro Lys Pro Asp 
        115                 120                 125             


Leu Val Leu Phe Leu Gln Leu Gln Leu Ala Asp Ala Ala Lys Arg Gly 
    130                 135                 140                 


Ala Phe Gly His Glu Arg Tyr Glu Asn Gly Ala Phe Gln Glu Arg Ala 
145                 150                 155                 160 


Leu Arg Cys Phe His Gln Leu Met Lys Asp Thr Thr Leu Asn Trp Lys 
                165                 170                 175     


Met Val Asp Ala Ser Lys Ser Ile Glu Ala Val His Glu Asp Ile Arg 
            180                 185                 190         


Val Leu Ser Glu Asp Ala Ile Arg Thr Ala Thr Glu Lys Pro Leu Gly 
        195                 200                 205             


Glu Leu Trp Lys 
    210         


<210>  33
<211>  523
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Leu Leu Arg Arg Leu Leu Gln Arg Glu Arg Pro Ser Ala 
1               5                   10                  15      


Ala Ser Gly Arg Pro Val Gly Arg Arg Glu Ala Asn Leu Gly Thr Asp 
            20                  25                  30          


Ala Gly Val Ala Val Arg Val Arg Phe Ala Pro Ser Pro Thr Gly Phe 
        35                  40                  45              


Leu His Leu Gly Gly Leu Arg Thr Ala Leu Tyr Asn Tyr Ile Phe Ala 
    50                  55                  60                  


Lys Lys Tyr Gln Gly Ser Phe Ile Leu Arg Leu Glu Asp Thr Asp Gln 
65                  70                  75                  80  


Thr Arg Val Val Pro Gly Ala Ala Glu Asn Ile Glu Asp Met Leu Glu 
                85                  90                  95      


Trp Ala Gly Ile Pro Pro Asp Glu Ser Pro Arg Arg Gly Gly Pro Ala 
            100                 105                 110         


Gly Pro Tyr Gln Gln Ser Gln Arg Leu Glu Leu Tyr Ala Gln Ala Thr 
        115                 120                 125             


Glu Ala Leu Leu Lys Thr Gly Ala Ala Tyr Pro Cys Phe Cys Ser Pro 
    130                 135                 140                 


Gln Arg Leu Glu Leu Leu Lys Lys Glu Ala Leu Arg Asn His Gln Thr 
145                 150                 155                 160 


Pro Arg Tyr Asp Asn Arg Cys Arg Asn Met Ser Gln Glu Gln Val Ala 
                165                 170                 175     


Gln Lys Leu Ala Lys Asp Pro Lys Pro Ala Ile Arg Phe Arg Leu Glu 
            180                 185                 190         


Gln Val Val Pro Ala Phe Gln Asp Leu Val Tyr Gly Trp Asn Arg His 
        195                 200                 205             


Glu Val Ala Ser Val Glu Gly Asp Pro Val Ile Met Lys Ser Asp Gly 
    210                 215                 220                 


Phe Pro Thr Tyr His Leu Ala Cys Val Val Asp Asp His His Met Gly 
225                 230                 235                 240 


Ile Ser His Val Leu Arg Gly Ser Glu Trp Leu Val Ser Thr Ala Lys 
                245                 250                 255     


His Leu Leu Leu Tyr Gln Ala Leu Gly Trp Gln Pro Pro His Phe Ala 
            260                 265                 270         


His Leu Pro Leu Leu Leu Asn Arg Asp Gly Ser Lys Leu Ser Lys Arg 
        275                 280                 285             


Gln Gly Asp Val Phe Leu Glu His Phe Ala Ala Asp Gly Phe Leu Pro 
    290                 295                 300                 


Asp Ser Leu Leu Asp Ile Ile Thr Asn Cys Gly Ser Gly Phe Ala Glu 
305                 310                 315                 320 


Asn Gln Met Gly Arg Thr Leu Pro Glu Leu Ile Thr Gln Phe Asn Leu 
                325                 330                 335     


Thr Gln Val Thr Cys His Ser Ala Leu Leu Asp Leu Glu Lys Leu Pro 
            340                 345                 350         


Glu Phe Asn Arg Leu His Leu Gln Arg Leu Val Ser Asn Glu Ser Gln 
        355                 360                 365             


Arg Arg Gln Leu Val Gly Lys Leu Gln Val Leu Val Glu Glu Ala Phe 
    370                 375                 380                 


Gly Cys Gln Leu Gln Asn Arg Asp Val Leu Asn Pro Val Tyr Val Glu 
385                 390                 395                 400 


Arg Ile Leu Leu Leu Arg Gln Gly His Ile Cys Arg Leu Gln Asp Leu 
                405                 410                 415     


Val Ser Pro Val Tyr Ser Tyr Leu Trp Thr Arg Pro Ala Val Gly Arg 
            420                 425                 430         


Ala Gln Leu Asp Ala Ile Ser Glu Lys Val Asp Val Ile Ala Lys Arg 
        435                 440                 445             


Val Leu Gly Leu Leu Glu Arg Ser Ser Met Ser Leu Thr Gln Asp Met 
    450                 455                 460                 


Leu Asn Gly Glu Leu Lys Lys Leu Ser Glu Gly Leu Glu Gly Thr Lys 
465                 470                 475                 480 


Tyr Ser Asn Val Met Lys Leu Leu Arg Met Ala Leu Ser Gly Gln Gln 
                485                 490                 495     


Gln Gly Pro Pro Val Ala Glu Met Met Leu Ala Leu Gly Pro Lys Glu 
            500                 505                 510         


Val Arg Glu Arg Ile Gln Lys Val Val Ser Ser 
        515                 520             


<210>  34
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys 
1               5                   10                  15      


Ala Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser 
        35                  40                  45              


Ala Arg Ala Gly Glu Thr Arg Phe Thr Asp Thr Arg Lys Asp Glu Gln 
    50                  55                  60                  


Glu Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu 
65                  70                  75                  80  


Leu Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala 
                85                  90                  95      


Gly Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser 
            100                 105                 110         


Ser Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val 
        115                 120                 125             


Val Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg 
    130                 135                 140                 


Gln Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met 
145                 150                 155                 160 


Asp Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln 
                165                 170                 175     


Thr Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr 
            180                 185                 190         


Gly Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val 
        195                 200                 205             


Leu Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr 
    210                 215                 220                 


Leu Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly 
225                 230                 235                 240 


Glu Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met 
                245                 250                 255     


Met Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys 
            260                 265                 270         


Phe Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr 
        275                 280                 285             


Phe Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile 
    290                 295                 300                 


Met Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp 
305                 310                 315                 320 


Ile Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu 
                325                 330                 335     


Lys Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln 
            340                 345                 350         


Met Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg 
        355                 360                 365             


Cys Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly 
    370                 375                 380                 


Ile Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys 
385                 390                 395                 400 


Met Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val 
                405                 410                 415     


Phe Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro 
            420                 425                 430         


Asn Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln 
        435                 440                 445             


Arg Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val 
    450                 455                 460                 


Pro Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val 
465                 470                 475                 480 


Lys Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val 
                485                 490                 495     


Met Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys 
            500                 505                 510         


Asn Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala 
        515                 520                 525             


Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His 
    530                 535                 540                 


Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp 
545                 550                 555                 560 


Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val 
                565                 570                 575     


Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu 
            580                 585                 590         


Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro 
        595                 600                 605             


Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala 
    610                 615                 620                 


Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu 
625                 630                 635                 640 


Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly 
                645                 650                 655     


Thr Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu 
            660                 665                 670         


Asn Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys 
        675                 680                 685             


Glu Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val 
    690                 695                 700                 


His Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln 
705                 710                 715                 720 


Ile Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala 
                725                 730                 735     


Gln Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro 
            740                 745                 750         


Glu Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly 
        755                 760                 765             


His Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val 
    770                 775                 780                 


Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu 
785                 790                 795                 800 


Arg Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His 
                805                 810                 815     


Trp Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser 
            820                 825                 830         


Gln Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile 
        835                 840                 845             


Pro Ala Leu Asp Asn Phe Leu Asp Lys Leu 
    850                 855             


<210>  35
<211>  1298
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Ala Asp Ala Glu Ala Val Pro Ala Arg Gly Glu Pro Gln 
1               5                   10                  15      


Gln Asp Cys Cys Val Lys Thr Glu Leu Leu Gly Glu Glu Thr Pro Met 
            20                  25                  30          


Ala Ala Asp Glu Gly Ser Ala Glu Lys Gln Ala Gly Glu Ala His Met 
        35                  40                  45              


Ala Ala Asp Gly Glu Thr Asn Gly Ser Cys Glu Asn Ser Asp Ala Ser 
    50                  55                  60                  


Ser His Ala Asn Ala Ala Lys His Thr Gln Asp Ser Ala Arg Val Asn 
65                  70                  75                  80  


Pro Gln Asp Gly Thr Asn Thr Leu Thr Arg Ile Ala Glu Asn Gly Val 
                85                  90                  95      


Ser Glu Arg Asp Ser Glu Ala Ala Lys Gln Asn His Val Thr Ala Asp 
            100                 105                 110         


Asp Phe Val Gln Thr Ser Val Ile Gly Ser Asn Gly Tyr Ile Leu Asn 
        115                 120                 125             


Lys Pro Ala Leu Gln Ala Gln Pro Leu Arg Thr Thr Ser Thr Leu Ala 
    130                 135                 140                 


Ser Ser Leu Pro Gly His Ala Ala Lys Thr Leu Pro Gly Gly Ala Gly 
145                 150                 155                 160 


Lys Gly Arg Thr Pro Ser Ala Phe Pro Gln Thr Pro Ala Ala Pro Pro 
                165                 170                 175     


Ala Thr Leu Gly Glu Gly Ser Ala Asp Thr Glu Asp Arg Lys Leu Pro 
            180                 185                 190         


Ala Pro Gly Ala Asp Val Lys Val His Arg Ala Arg Lys Thr Met Pro 
        195                 200                 205             


Lys Ser Val Val Gly Leu His Ala Ala Ser Lys Asp Pro Arg Glu Val 
    210                 215                 220                 


Arg Glu Ala Arg Asp His Lys Glu Pro Lys Glu Glu Ile Asn Lys Asn 
225                 230                 235                 240 


Ile Ser Asp Phe Gly Arg Gln Gln Leu Leu Pro Pro Phe Pro Ser Leu 
                245                 250                 255     


His Gln Ser Leu Pro Gln Asn Gln Cys Tyr Met Ala Thr Thr Lys Ser 
            260                 265                 270         


Gln Thr Ala Cys Leu Pro Phe Val Leu Ala Ala Ala Val Ser Arg Lys 
        275                 280                 285             


Lys Lys Arg Arg Met Gly Thr Tyr Ser Leu Val Pro Lys Lys Lys Thr 
    290                 295                 300                 


Lys Val Leu Lys Gln Arg Thr Val Ile Glu Met Phe Lys Ser Ile Thr 
305                 310                 315                 320 


His Ser Thr Val Gly Ser Lys Gly Glu Lys Asp Leu Gly Ala Ser Ser 
                325                 330                 335     


Leu His Val Asn Gly Glu Ser Leu Glu Met Asp Ser Asp Glu Asp Asp 
            340                 345                 350         


Ser Glu Glu Leu Glu Glu Asp Asp Gly His Gly Ala Glu Gln Ala Ala 
        355                 360                 365             


Ala Phe Pro Thr Glu Asp Ser Arg Thr Ser Lys Glu Ser Met Ser Glu 
    370                 375                 380                 


Ala Asp Arg Ala Gln Lys Met Asp Gly Glu Ser Glu Glu Glu Gln Glu 
385                 390                 395                 400 


Ser Val Asp Thr Gly Glu Glu Glu Glu Gly Gly Asp Glu Ser Asp Leu 
                405                 410                 415     


Ser Ser Glu Ser Ser Ile Lys Lys Lys Phe Leu Lys Arg Lys Gly Lys 
            420                 425                 430         


Thr Asp Ser Pro Trp Ile Lys Pro Ala Arg Lys Arg Arg Arg Arg Ser 
        435                 440                 445             


Arg Lys Lys Pro Ser Gly Ala Leu Gly Ser Glu Ser Tyr Lys Ser Ser 
    450                 455                 460                 


Ala Gly Ser Ala Glu Gln Thr Ala Pro Gly Asp Ser Thr Gly Tyr Met 
465                 470                 475                 480 


Glu Val Ser Leu Asp Ser Leu Asp Leu Arg Val Lys Gly Ile Leu Ser 
                485                 490                 495     


Ser Gln Ala Glu Gly Leu Ala Asn Gly Pro Asp Val Leu Glu Thr Asp 
            500                 505                 510         


Gly Leu Gln Glu Val Pro Leu Cys Ser Cys Arg Met Glu Thr Pro Lys 
        515                 520                 525             


Ser Arg Glu Ile Thr Thr Leu Ala Asn Asn Gln Cys Met Ala Thr Glu 
    530                 535                 540                 


Ser Val Asp His Glu Leu Gly Arg Cys Thr Asn Ser Val Val Lys Tyr 
545                 550                 555                 560 


Glu Leu Met Arg Pro Ser Asn Lys Ala Pro Leu Leu Val Leu Cys Glu 
                565                 570                 575     


Asp His Arg Gly Arg Met Val Lys His Gln Cys Cys Pro Gly Cys Gly 
            580                 585                 590         


Tyr Phe Cys Thr Ala Gly Asn Phe Met Glu Cys Gln Pro Glu Ser Ser 
        595                 600                 605             


Ile Ser His Arg Phe His Lys Asp Cys Ala Ser Arg Val Asn Asn Ala 
    610                 615                 620                 


Ser Tyr Cys Pro His Cys Gly Glu Glu Ser Ser Lys Ala Lys Glu Val 
625                 630                 635                 640 


Thr Ile Ala Lys Ala Asp Thr Thr Ser Thr Val Thr Pro Val Pro Gly 
                645                 650                 655     


Gln Glu Lys Gly Ser Ala Leu Glu Gly Arg Ala Asp Thr Thr Thr Gly 
            660                 665                 670         


Ser Ala Ala Gly Pro Pro Leu Ser Glu Asp Asp Lys Leu Gln Gly Ala 
        675                 680                 685             


Ala Ser His Val Pro Glu Gly Phe Asp Pro Thr Gly Pro Ala Gly Leu 
    690                 695                 700                 


Gly Arg Pro Thr Pro Gly Leu Ser Gln Gly Pro Gly Lys Glu Thr Leu 
705                 710                 715                 720 


Glu Ser Ala Leu Ile Ala Leu Asp Ser Glu Lys Pro Lys Lys Leu Arg 
                725                 730                 735     


Phe His Pro Lys Gln Leu Tyr Phe Ser Ala Arg Gln Gly Glu Leu Gln 
            740                 745                 750         


Lys Val Leu Leu Met Leu Val Asp Gly Ile Asp Pro Asn Phe Lys Met 
        755                 760                 765             


Glu His Gln Asn Lys Arg Ser Pro Leu His Ala Ala Ala Glu Ala Gly 
    770                 775                 780                 


His Val Asp Ile Cys His Met Leu Val Gln Ala Gly Ala Asn Ile Asp 
785                 790                 795                 800 


Thr Cys Ser Glu Asp Gln Arg Thr Pro Leu Met Glu Ala Ala Glu Asn 
                805                 810                 815     


Asn His Leu Glu Ala Val Lys Tyr Leu Ile Lys Ala Gly Ala Leu Val 
            820                 825                 830         


Asp Pro Lys Asp Ala Glu Gly Ser Thr Cys Leu His Leu Ala Ala Lys 
        835                 840                 845             


Lys Gly His Tyr Glu Val Val Gln Tyr Leu Leu Ser Asn Gly Gln Met 
    850                 855                 860                 


Asp Val Asn Cys Gln Asp Asp Gly Gly Trp Thr Pro Met Ile Trp Ala 
865                 870                 875                 880 


Thr Glu Tyr Lys His Val Asp Leu Val Lys Leu Leu Leu Ser Lys Gly 
                885                 890                 895     


Ser Asp Ile Asn Ile Arg Asp Asn Glu Glu Asn Ile Cys Leu His Trp 
            900                 905                 910         


Ala Ala Phe Ser Gly Cys Val Asp Ile Ala Glu Ile Leu Leu Ala Ala 
        915                 920                 925             


Lys Cys Asp Leu His Ala Val Asn Ile His Gly Asp Ser Pro Leu His 
    930                 935                 940                 


Ile Ala Ala Arg Glu Asn Arg Tyr Asp Cys Val Val Leu Phe Leu Ser 
945                 950                 955                 960 


Arg Asp Ser Asp Val Thr Leu Lys Asn Lys Glu Gly Glu Thr Pro Leu 
                965                 970                 975     


Gln Cys Ala Ser Leu Asn Ser Gln Val Trp Ser Ala Leu Gln Met Ser 
            980                 985                 990         


Lys Ala Leu Gln Asp Ser Ala Pro  Asp Arg Pro Ser Pro  Val Glu Arg 
        995                 1000                 1005             


Ile Val  Ser Arg Asp Ile Ala  Arg Gly Tyr Glu Arg  Ile Pro Ile 
    1010                 1015                 1020             


Pro Cys  Val Asn Ala Val Asp  Ser Glu Pro Cys Pro  Ser Asn Tyr 
    1025                 1030                 1035             


Lys Tyr  Val Ser Gln Asn Cys  Val Thr Ser Pro Met  Asn Ile Asp 
    1040                 1045                 1050             


Arg Asn  Ile Thr His Leu Gln  Tyr Cys Val Cys Ile  Asp Asp Cys 
    1055                 1060                 1065             


Ser Ser  Ser Asn Cys Met Cys  Gly Gln Leu Ser Met  Arg Cys Trp 
    1070                 1075                 1080             


Tyr Asp  Lys Asp Gly Arg Leu  Leu Pro Glu Phe Asn  Met Ala Glu 
    1085                 1090                 1095             


Pro Pro  Leu Ile Phe Glu Cys  Asn His Ala Cys Ser  Cys Trp Arg 
    1100                 1105                 1110             


Asn Cys  Arg Asn Arg Val Val  Gln Asn Gly Leu Arg  Ala Arg Leu 
    1115                 1120                 1125             


Gln Leu  Tyr Arg Thr Arg Asp  Met Gly Trp Gly Val  Arg Ser Leu 
    1130                 1135                 1140             


Gln Asp  Ile Pro Pro Gly Thr  Phe Val Cys Glu Tyr  Val Gly Glu 
    1145                 1150                 1155             


Leu Ile  Ser Asp Ser Glu Ala  Asp Val Arg Glu Glu  Asp Ser Tyr 
    1160                 1165                 1170             


Leu Phe  Asp Leu Asp Asn Lys  Asp Gly Glu Val Tyr  Cys Ile Asp 
    1175                 1180                 1185             


Ala Arg  Phe Tyr Gly Asn Val  Ser Arg Phe Ile Asn  His His Cys 
    1190                 1195                 1200             


Glu Pro  Asn Leu Val Pro Val  Arg Val Phe Met Ala  His Gln Asp 
    1205                 1210                 1215             


Leu Arg  Phe Pro Arg Ile Ala  Phe Phe Ser Thr Arg  Leu Ile Glu 
    1220                 1225                 1230             


Ala Gly  Glu Gln Leu Gly Phe  Asp Tyr Gly Glu Arg  Phe Trp Asp 
    1235                 1240                 1245             


Ile Lys  Gly Lys Leu Phe Ser  Cys Arg Cys Gly Ser  Pro Lys Cys 
    1250                 1255                 1260             


Arg His  Ser Ser Ala Ala Leu  Ala Gln Arg Gln Ala  Ser Ala Ala 
    1265                 1270                 1275             


Gln Glu  Ala Gln Glu Asp Gly  Leu Pro Asp Thr Ser  Ser Ala Ala 
    1280                 1285                 1290             


Ala Ala  Asp Pro Leu 
    1295             


<210>  36
<211>  2414
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210>  37
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Leu Asn Val Asp Gly Leu Leu Val Tyr Phe Pro Tyr Asp Tyr 
1               5                   10                  15      


Ile Tyr Pro Glu Gln Phe Ser Tyr Met Arg Glu Leu Lys Arg Thr Leu 
            20                  25                  30          


Asp Ala Lys Gly His Gly Val Leu Glu Met Pro Ser Gly Thr Gly Lys 
        35                  40                  45              


Thr Val Ser Leu Leu Ala Leu Ile Met Ala Tyr Gln Arg Ala Tyr Pro 
    50                  55                  60                  


Leu Glu Val Thr Lys Leu Ile Tyr Cys Ser Arg Thr Val Pro Glu Ile 
65                  70                  75                  80  


Glu Lys Val Ile Glu Glu Leu Arg Lys Leu Leu Asn Phe Tyr Glu Lys 
                85                  90                  95      


Gln Glu Gly Glu Lys Leu Pro Phe Leu Gly Leu Ala Leu Ser Ser Arg 
            100                 105                 110         


Lys Asn Leu Cys Ile His Pro Glu Val Thr Pro Leu Arg Phe Gly Lys 
        115                 120                 125             


Asp Val Asp Gly Lys Cys His Ser Leu Thr Ala Ser Tyr Val Arg Ala 
    130                 135                 140                 


Gln Tyr Gln His Asp Thr Ser Leu Pro His Cys Arg Phe Tyr Glu Glu 
145                 150                 155                 160 


Phe Asp Ala His Gly Arg Glu Val Pro Leu Pro Ala Gly Ile Tyr Asn 
                165                 170                 175     


Leu Asp Asp Leu Lys Ala Leu Gly Arg Arg Gln Gly Trp Cys Pro Tyr 
            180                 185                 190         


Phe Leu Ala Arg Tyr Ser Ile Leu His Ala Asn Val Val Val Tyr Ser 
        195                 200                 205             


Tyr His Tyr Leu Leu Asp Pro Lys Ile Ala Asp Leu Val Ser Lys Glu 
    210                 215                 220                 


Leu Ala Arg Lys Ala Val Val Val Phe Asp Glu Ala His Asn Ile Asp 
225                 230                 235                 240 


Asn Val Cys Ile Asp Ser Met Ser Val Asn Leu Thr Arg Arg Thr Leu 
                245                 250                 255     


Asp Arg Cys Gln Gly Asn Leu Glu Thr Leu Gln Lys Thr Val Leu Arg 
            260                 265                 270         


Ile Lys Glu Thr Asp Glu Gln Arg Leu Arg Asp Glu Tyr Arg Arg Leu 
        275                 280                 285             


Val Glu Gly Leu Arg Glu Ala Ser Ala Ala Arg Glu Thr Asp Ala His 
    290                 295                 300                 


Leu Ala Asn Pro Val Leu Pro Asp Glu Val Leu Gln Glu Ala Val Pro 
305                 310                 315                 320 


Gly Ser Ile Arg Thr Ala Glu His Phe Leu Gly Phe Leu Arg Arg Leu 
                325                 330                 335     


Leu Glu Tyr Val Lys Trp Arg Leu Arg Val Gln His Val Val Gln Glu 
            340                 345                 350         


Ser Pro Pro Ala Phe Leu Ser Gly Leu Ala Gln Arg Val Cys Ile Gln 
        355                 360                 365             


Arg Lys Pro Leu Arg Phe Cys Ala Glu Arg Leu Arg Ser Leu Leu His 
    370                 375                 380                 


Thr Leu Glu Ile Thr Asp Leu Ala Asp Phe Ser Pro Leu Thr Leu Leu 
385                 390                 395                 400 


Ala Asn Phe Ala Thr Leu Val Ser Thr Tyr Ala Lys Gly Phe Thr Ile 
                405                 410                 415     


Ile Ile Glu Pro Phe Asp Asp Arg Thr Pro Thr Ile Ala Asn Pro Ile 
            420                 425                 430         


Leu His Phe Ser Cys Met Asp Ala Ser Leu Ala Ile Lys Pro Val Phe 
        435                 440                 445             


Glu Arg Phe Gln Ser Val Ile Ile Thr Ser Gly Thr Leu Ser Pro Leu 
    450                 455                 460                 


Asp Ile Tyr Pro Lys Ile Leu Asp Phe His Pro Val Thr Met Ala Thr 
465                 470                 475                 480 


Phe Thr Met Thr Leu Ala Arg Val Cys Leu Cys Pro Met Ile Ile Gly 
                485                 490                 495     


Arg Gly Asn Asp Gln Val Ala Ile Ser Ser Lys Phe Glu Thr Arg Glu 
            500                 505                 510         


Asp Ile Ala Val Ile Arg Asn Tyr Gly Asn Leu Leu Leu Glu Met Ser 
        515                 520                 525             


Ala Val Val Pro Asp Gly Ile Val Ala Phe Phe Thr Ser Tyr Gln Tyr 
    530                 535                 540                 


Met Glu Ser Thr Val Ala Ser Trp Tyr Glu Gln Gly Ile Leu Glu Asn 
545                 550                 555                 560 


Ile Gln Arg Asn Lys Leu Leu Phe Ile Glu Thr Gln Asp Gly Ala Glu 
                565                 570                 575     


Thr Ser Val Ala Leu Glu Lys Tyr Gln Glu Ala Cys Glu Asn Gly Arg 
            580                 585                 590         


Gly Ala Ile Leu Leu Ser Val Ala Arg Gly Lys Val Ser Glu Gly Ile 
        595                 600                 605             


Asp Phe Val His His Tyr Gly Arg Ala Val Ile Met Phe Gly Val Pro 
    610                 615                 620                 


Tyr Val Tyr Thr Gln Ser Arg Ile Leu Lys Ala Arg Leu Glu Tyr Leu 
625                 630                 635                 640 


Arg Asp Gln Phe Gln Ile Arg Glu Asn Asp Phe Leu Thr Phe Asp Ala 
                645                 650                 655     


Met Arg His Ala Ala Gln Cys Val Gly Arg Ala Ile Arg Gly Lys Thr 
            660                 665                 670         


Asp Tyr Gly Leu Met Val Phe Ala Asp Lys Arg Phe Ala Arg Gly Asp 
        675                 680                 685             


Lys Arg Gly Lys Leu Pro Arg Trp Ile Gln Glu His Leu Thr Asp Ala 
    690                 695                 700                 


Asn Leu Asn Leu Thr Val Asp Glu Gly Val Gln Val Ala Lys Tyr Phe 
705                 710                 715                 720 


Leu Arg Gln Met Ala Gln Pro Phe His Arg Glu Asp Gln Leu Gly Leu 
                725                 730                 735     


Ser Leu Leu Ser Leu Glu Gln Leu Glu Ser Glu Glu Thr Leu Lys Arg 
            740                 745                 750         


Ile Glu Gln Ile Ala Gln Gln Leu 
        755                 760 


<210>  38
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Pro Thr Val Ser Val Lys Arg Asp Leu Leu Phe Gln Ala Leu Gly 
1               5                   10                  15      


Arg Thr Tyr Thr Asp Glu Glu Phe Asp Glu Leu Cys Phe Glu Phe Gly 
            20                  25                  30          


Leu Glu Leu Asp Glu Ile Thr Ser Glu Lys Glu Ile Ile Ser Lys Glu 
        35                  40                  45              


Gln Gly Asn Val Lys Ala Ala Gly Ala Ser Asp Val Val Leu Tyr Lys 
    50                  55                  60                  


Ile Asp Val Pro Ala Asn Arg Tyr Asp Leu Leu Cys Leu Glu Gly Leu 
65                  70                  75                  80  


Val Arg Gly Leu Gln Val Phe Lys Glu Arg Ile Lys Ala Pro Val Tyr 
                85                  90                  95      


Lys Arg Val Met Pro Asp Gly Lys Ile Gln Lys Leu Ile Ile Thr Glu 
            100                 105                 110         


Glu Thr Ala Lys Ile Arg Pro Phe Ala Val Ala Ala Val Leu Arg Asn 
        115                 120                 125             


Ile Lys Phe Thr Lys Asp Arg Tyr Asp Ser Phe Ile Glu Leu Gln Glu 
    130                 135                 140                 


Lys Leu His Gln Asn Ile Cys Arg Lys Arg Ala Leu Val Ala Ile Gly 
145                 150                 155                 160 


Thr His Asp Leu Asp Thr Leu Ser Gly Pro Phe Thr Tyr Thr Ala Lys 
                165                 170                 175     


Arg Pro Ser Asp Ile Lys Phe Lys Pro Leu Asn Lys Thr Lys Glu Tyr 
            180                 185                 190         


Thr Ala Cys Glu Leu Met Asn Ile Tyr Lys Thr Asp Asn His Leu Lys 
        195                 200                 205             


His Tyr Leu His Ile Ile Glu Asn Lys Pro Leu Tyr Pro Val Ile Tyr 
    210                 215                 220                 


Asp Ser Asn Gly Val Val Leu Ser Met Pro Pro Ile Ile Asn Gly Asp 
225                 230                 235                 240 


His Ser Arg Ile Thr Val Asn Thr Arg Asn Ile Phe Ile Glu Cys Thr 
                245                 250                 255     


Gly Thr Asp Phe Thr Lys Ala Lys Ile Val Leu Asp Ile Ile Val Thr 
            260                 265                 270         


Met Phe Ser Glu Tyr Cys Glu Asn Gln Phe Thr Val Glu Ala Ala Glu 
        275                 280                 285             


Val Val Phe Pro Asn Gly Lys Ser His Thr Phe Pro Glu Leu Ala Tyr 
    290                 295                 300                 


Arg Lys Glu Met Val Arg Ala Asp Leu Ile Asn Lys Lys Val Gly Ile 
305                 310                 315                 320 


Arg Glu Thr Pro Glu Asn Leu Ala Lys Leu Leu Thr Arg Met Tyr Leu 
                325                 330                 335     


Lys Ser Glu Val Ile Gly Asp Gly Asn Gln Ile Glu Ile Glu Ile Pro 
            340                 345                 350         


Pro Thr Arg Ala Asp Ile Ile His Ala Cys Asp Ile Val Glu Asp Ala 
        355                 360                 365             


Ala Ile Ala Tyr Gly Tyr Asn Asn Ile Gln Met Thr Leu Pro Lys Thr 
    370                 375                 380                 


Tyr Thr Ile Ala Asn Gln Phe Pro Leu Asn Lys Leu Thr Glu Leu Leu 
385                 390                 395                 400 


Arg His Asp Met Ala Ala Ala Gly Phe Thr Glu Ala Leu Thr Phe Ala 
                405                 410                 415     


Leu Cys Ser Gln Glu Asp Ile Ala Asp Lys Leu Gly Val Asp Ile Ser 
            420                 425                 430         


Ala Thr Lys Ala Val His Ile Ser Asn Pro Lys Thr Ala Glu Phe Gln 
        435                 440                 445             


Val Ala Arg Thr Thr Leu Leu Pro Gly Leu Leu Lys Thr Ile Ala Ala 
    450                 455                 460                 


Asn Arg Lys Met Pro Leu Pro Leu Lys Leu Phe Glu Ile Ser Asp Ile 
465                 470                 475                 480 


Val Ile Lys Asp Ser Asn Thr Asp Val Gly Ala Lys Asn Tyr Arg His 
                485                 490                 495     


Leu Cys Ala Val Tyr Tyr Asn Lys Asn Pro Gly Phe Glu Ile Ile His 
            500                 505                 510         


Gly Leu Leu Asp Arg Ile Met Gln Leu Leu Asp Val Pro Pro Gly Glu 
        515                 520                 525             


Asp Lys Gly Gly Tyr Val Ile Lys Ala Ser Glu Gly Pro Ala Phe Phe 
    530                 535                 540                 


Pro Gly Arg Cys Ala Glu Ile Phe Ala Arg Gly Gln Ser Val Gly Lys 
545                 550                 555                 560 


Leu Gly Val Leu His Pro Asp Val Ile Thr Lys Phe Glu Leu Thr Met 
                565                 570                 575     


Pro Cys Ser Ser Leu Glu Ile Asn Val Gly Pro Phe Leu 
            580                 585                 


<210>  39
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Ser Arg Cys Trp Arg Trp Trp Gly Trp Ser Ala Trp Pro Arg 
1               5                   10                  15      


Thr Arg Leu Pro Pro Ala Gly Ser Thr Pro Ser Phe Cys His His Phe 
            20                  25                  30          


Ser Thr Gln Glu Lys Thr Pro Gln Ile Cys Val Val Gly Ser Gly Pro 
        35                  40                  45              


Ala Gly Phe Tyr Thr Ala Gln His Leu Leu Lys His Pro Gln Ala His 
    50                  55                  60                  


Val Asp Ile Tyr Glu Lys Gln Pro Val Pro Phe Gly Leu Val Arg Phe 
65                  70                  75                  80  


Gly Val Ala Pro Asp His Pro Glu Val Lys Asn Val Ile Asn Thr Phe 
                85                  90                  95      


Thr Gln Thr Ala His Ser Gly Arg Cys Ala Phe Trp Gly Asn Val Glu 
            100                 105                 110         


Val Gly Arg Asp Val Thr Val Pro Glu Leu Arg Glu Ala Tyr His Ala 
        115                 120                 125             


Val Val Leu Ser Tyr Gly Ala Glu Asp His Arg Ala Leu Glu Ile Pro 
    130                 135                 140                 


Gly Glu Glu Leu Pro Gly Val Cys Ser Ala Arg Ala Phe Val Gly Trp 
145                 150                 155                 160 


Tyr Asn Gly Leu Pro Glu Asn Gln Glu Leu Glu Pro Asp Leu Ser Cys 
                165                 170                 175     


Asp Thr Ala Val Ile Leu Gly Gln Gly Asn Val Ala Leu Asp Val Ala 
            180                 185                 190         


Arg Ile Leu Leu Thr Pro Pro Glu His Leu Glu Arg Thr Asp Ile Thr 
        195                 200                 205             


Lys Ala Ala Leu Gly Val Leu Arg Gln Ser Arg Val Lys Thr Val Trp 
    210                 215                 220                 


Leu Val Gly Arg Arg Gly Pro Leu Gln Val Ala Phe Thr Ile Lys Glu 
225                 230                 235                 240 


Leu Arg Glu Met Ile Gln Leu Pro Gly Ala Arg Pro Ile Leu Asp Pro 
                245                 250                 255     


Val Asp Phe Leu Gly Leu Gln Asp Lys Ile Lys Glu Val Pro Arg Pro 
            260                 265                 270         


Arg Lys Arg Leu Thr Glu Leu Leu Leu Arg Thr Ala Thr Glu Lys Pro 
        275                 280                 285             


Gly Pro Ala Glu Ala Ala Arg Gln Ala Ser Ala Ser Arg Ala Trp Gly 
    290                 295                 300                 


Leu Arg Phe Phe Arg Ser Pro Gln Gln Val Leu Pro Ser Pro Asp Gly 
305                 310                 315                 320 


Arg Arg Ala Ala Gly Val Arg Leu Ala Val Thr Arg Leu Glu Gly Val 
                325                 330                 335     


Asp Glu Ala Thr Arg Ala Val Pro Thr Gly Asp Met Glu Asp Leu Pro 
            340                 345                 350         


Cys Gly Leu Val Leu Ser Ser Ile Gly Tyr Lys Ser Arg Pro Val Asp 
        355                 360                 365             


Pro Ser Val Pro Phe Asp Ser Lys Leu Gly Val Ile Pro Asn Val Glu 
    370                 375                 380                 


Gly Arg Val Met Asp Val Pro Gly Leu Tyr Cys Ser Gly Trp Val Lys 
385                 390                 395                 400 


Arg Gly Pro Thr Gly Val Ile Ala Thr Thr Met Thr Asp Ser Phe Leu 
                405                 410                 415     


Thr Gly Gln Met Leu Leu Gln Asp Leu Lys Ala Gly Leu Leu Pro Ser 
            420                 425                 430         


Gly Pro Arg Pro Gly Tyr Ala Ala Ile Gln Ala Leu Leu Ser Ser Arg 
        435                 440                 445             


Gly Val Arg Pro Val Ser Phe Ser Asp Trp Glu Lys Leu Asp Ala Glu 
    450                 455                 460                 


Glu Val Ala Arg Gly Gln Gly Thr Gly Lys Pro Arg Glu Lys Leu Val 
465                 470                 475                 480 


Asp Pro Gln Glu Met Leu Arg Leu Leu Gly His 
                485                 490     


<210>  40
<211>  587
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ser Arg Ala Arg Ser His Leu Arg Ala Ala Leu Phe Leu Ala Ala 
1               5                   10                  15      


Ala Ser Ala Arg Gly Ile Thr Thr Gln Val Ala Ala Arg Arg Gly Leu 
            20                  25                  30          


Ser Ala Trp Pro Val Pro Gln Glu Pro Ser Met Glu Tyr Gln Asp Ala 
        35                  40                  45              


Val Arg Met Leu Asn Thr Leu Gln Thr Asn Ala Gly Tyr Leu Glu Gln 
    50                  55                  60                  


Val Lys Arg Gln Arg Gly Asp Pro Gln Thr Gln Leu Glu Ala Met Glu 
65                  70                  75                  80  


Leu Tyr Leu Ala Arg Ser Gly Leu Gln Val Glu Asp Leu Asp Arg Leu 
                85                  90                  95      


Asn Ile Ile His Val Thr Gly Thr Lys Gly Lys Gly Ser Thr Cys Ala 
            100                 105                 110         


Phe Thr Glu Cys Ile Leu Arg Ser Tyr Gly Leu Lys Thr Gly Phe Phe 
        115                 120                 125             


Ser Ser Pro His Leu Val Gln Val Arg Glu Arg Ile Arg Ile Asn Gly 
    130                 135                 140                 


Gln Pro Ile Ser Pro Glu Leu Phe Thr Lys Tyr Phe Trp Arg Leu Tyr 
145                 150                 155                 160 


His Arg Leu Glu Glu Thr Lys Asp Gly Ser Cys Val Ser Met Pro Pro 
                165                 170                 175     


Tyr Phe Arg Phe Leu Thr Leu Met Ala Phe His Val Phe Leu Gln Glu 
            180                 185                 190         


Lys Val Asp Leu Ala Val Val Glu Val Gly Ile Gly Gly Ala Tyr Asp 
        195                 200                 205             


Cys Thr Asn Ile Ile Arg Lys Pro Val Val Cys Gly Val Ser Ser Leu 
    210                 215                 220                 


Gly Ile Asp His Thr Ser Leu Leu Gly Asp Thr Val Glu Lys Ile Ala 
225                 230                 235                 240 


Trp Gln Lys Gly Gly Ile Phe Lys Gln Gly Val Pro Ala Phe Thr Val 
                245                 250                 255     


Leu Gln Pro Glu Gly Pro Leu Ala Val Leu Arg Asp Arg Ala Gln Gln 
            260                 265                 270         


Ile Ser Cys Pro Leu Tyr Leu Cys Pro Met Leu Glu Ala Leu Glu Glu 
        275                 280                 285             


Gly Gly Pro Pro Leu Thr Leu Gly Leu Glu Gly Glu His Gln Arg Ser 
    290                 295                 300                 


Asn Ala Ala Leu Ala Leu Gln Leu Ala His Cys Trp Leu Gln Arg Gln 
305                 310                 315                 320 


Asp Arg His Gly Ala Gly Glu Pro Lys Ala Ser Arg Pro Gly Leu Leu 
                325                 330                 335     


Trp Gln Leu Pro Leu Ala Pro Val Phe Gln Pro Thr Ser His Met Arg 
            340                 345                 350         


Leu Gly Leu Arg Asn Thr Glu Trp Pro Gly Arg Thr Gln Val Leu Arg 
        355                 360                 365             


Arg Gly Pro Leu Thr Trp Tyr Leu Asp Gly Ala His Thr Ala Ser Ser 
    370                 375                 380                 


Ala Gln Ala Cys Val Arg Trp Phe Arg Gln Ala Leu Gln Gly Arg Glu 
385                 390                 395                 400 


Arg Pro Ser Gly Gly Pro Glu Val Arg Val Leu Leu Phe Asn Ala Thr 
                405                 410                 415     


Gly Asp Arg Asp Pro Ala Ala Leu Leu Lys Leu Leu Gln Pro Cys Gln 
            420                 425                 430         


Phe Asp Tyr Ala Val Phe Cys Pro Asn Leu Thr Glu Val Ser Ser Thr 
        435                 440                 445             


Gly Asn Ala Asp Gln Gln Asn Phe Thr Val Thr Leu Asp Gln Val Leu 
    450                 455                 460                 


Leu Arg Cys Leu Glu His Gln Gln His Trp Asn His Leu Asp Glu Glu 
465                 470                 475                 480 


Gln Ala Ser Pro Asp Leu Trp Ser Ala Pro Ser Pro Glu Pro Gly Gly 
                485                 490                 495     


Ser Ala Ser Leu Leu Leu Ala Pro His Pro Pro His Thr Cys Ser Ala 
            500                 505                 510         


Ser Ser Leu Val Phe Ser Cys Ile Ser His Ala Leu Gln Trp Ile Ser 
        515                 520                 525             


Gln Gly Arg Asp Pro Ile Phe Gln Pro Pro Ser Pro Pro Lys Gly Leu 
    530                 535                 540                 


Leu Thr His Pro Val Ala His Ser Gly Ala Ser Ile Leu Arg Glu Ala 
545                 550                 555                 560 


Ala Ala Ile His Val Leu Val Thr Gly Ser Leu His Leu Val Gly Gly 
                565                 570                 575     


Val Leu Lys Leu Leu Glu Pro Ala Leu Ser Gln 
            580                 585         


<210>  41
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Ile Arg Gly Met Leu Arg Ala Ala Val Ile Leu Leu Leu Ile 
1               5                   10                  15      


Arg Thr Trp Leu Ala Glu Gly Asn Tyr Pro Ser Pro Ile Pro Lys Phe 
            20                  25                  30          


His Phe Glu Phe Ser Ser Ala Val Pro Glu Val Val Leu Asn Leu Phe 
        35                  40                  45              


Asn Cys Lys Asn Cys Ala Asn Glu Ala Val Val Gln Lys Ile Leu Asp 
    50                  55                  60                  


Arg Val Leu Ser Arg Tyr Asp Val Arg Leu Arg Pro Asn Phe Gly Gly 
65                  70                  75                  80  


Ala Pro Val Pro Val Arg Ile Ser Ile Tyr Val Thr Ser Ile Glu Gln 
                85                  90                  95      


Ile Ser Glu Met Asn Met Asp Tyr Thr Ile Thr Met Phe Phe His Gln 
            100                 105                 110         


Thr Trp Lys Asp Ser Arg Leu Ala Tyr Tyr Glu Thr Thr Leu Asn Leu 
        115                 120                 125             


Thr Leu Asp Tyr Arg Met His Glu Lys Leu Trp Val Pro Asp Cys Tyr 
    130                 135                 140                 


Phe Leu Asn Ser Lys Asp Ala Phe Val His Asp Val Thr Val Glu Asn 
145                 150                 155                 160 


Arg Val Phe Gln Leu His Pro Asp Gly Thr Val Arg Tyr Gly Ile Arg 
                165                 170                 175     


Leu Thr Thr Thr Ala Ala Cys Ser Leu Asp Leu His Lys Phe Pro Met 
            180                 185                 190         


Asp Lys Gln Ala Cys Asn Leu Val Val Glu Ser Tyr Gly Tyr Thr Val 
        195                 200                 205             


Glu Asp Ile Ile Leu Phe Trp Asp Asp Asn Gly Asn Ala Ile His Met 
    210                 215                 220                 


Thr Glu Glu Leu His Ile Pro Gln Phe Thr Phe Leu Gly Arg Thr Ile 
225                 230                 235                 240 


Thr Ser Lys Glu Val Tyr Phe Tyr Thr Gly Ser Tyr Ile Arg Leu Ile 
                245                 250                 255     


Leu Lys Phe Gln Val Gln Arg Glu Val Asn Ser Tyr Leu Val Gln Val 
            260                 265                 270         


Tyr Trp Pro Thr Val Leu Thr Thr Ile Thr Ser Trp Ile Ser Phe Trp 
        275                 280                 285             


Met Asn Tyr Asp Ser Ser Ala Ala Arg Val Thr Ile Gly Leu Thr Ser 
    290                 295                 300                 


Met Leu Ile Leu Thr Thr Ile Asp Ser His Leu Arg Asp Lys Leu Pro 
305                 310                 315                 320 


Asn Ile Ser Cys Ile Lys Ala Ile Asp Ile Tyr Ile Leu Val Cys Leu 
                325                 330                 335     


Phe Phe Val Phe Leu Ser Leu Leu Glu Tyr Val Tyr Ile Asn Tyr Leu 
            340                 345                 350         


Phe Tyr Ser Arg Gly Pro Arg Arg Gln Pro Arg Arg His Arg Arg Pro 
        355                 360                 365             


Arg Arg Val Ile Ala Arg Tyr Arg Tyr Gln Gln Val Val Val Gly Asn 
    370                 375                 380                 


Val Gln Asp Gly Leu Ile Asn Val Glu Asp Gly Val Ser Ser Leu Pro 
385                 390                 395                 400 


Ile Thr Pro Ala Gln Ala Pro Leu Ala Ser Pro Glu Ser Leu Gly Ser 
                405                 410                 415     


Leu Thr Ser Thr Ser Glu Gln Ala Gln Leu Ala Thr Ser Glu Ser Leu 
            420                 425                 430         


Ser Pro Leu Thr Ser Leu Ser Gly Gln Ala Pro Leu Ala Thr Gly Glu 
        435                 440                 445             


Ser Leu Ser Asp Leu Pro Ser Thr Ser Glu Gln Ala Arg His Ser Tyr 
    450                 455                 460                 


Gly Val Arg Phe Asn Gly Phe Gln Ala Asp Asp Ser Ile Phe Pro Thr 
465                 470                 475                 480 


Glu Ile Arg Asn Arg Val Glu Ala His Gly His Gly Val Thr His Asp 
                485                 490                 495     


His Glu Asp Ser Asn Glu Ser Leu Ser Ser Asp Glu Arg His Gly His 
            500                 505                 510         


Gly Pro Ser Gly Lys Pro Met Leu His His Gly Glu Lys Gly Val Gln 
        515                 520                 525             


Glu Ala Gly Trp Asp Leu Asp Asp Asn Asn Asp Lys Ser Asp Cys Leu 
    530                 535                 540                 


Ala Ile Lys Glu Gln Phe Lys Cys Asp Thr Asn Ser Thr Trp Gly Leu 
545                 550                 555                 560 


Asn Asp Asp Glu Leu Met Ala His Gly Gln Glu Lys Asp Ser Ser Ser 
                565                 570                 575     


Glu Ser Glu Asp Ser Cys Pro Pro Ser Pro Gly Cys Ser Phe Thr Glu 
            580                 585                 590         


Gly Phe Ser Phe Asp Leu Phe Asn Pro Asp Tyr Val Pro Lys Val Asp 
        595                 600                 605             


Lys Trp Ser Arg Phe Leu Phe Pro Leu Ala Phe Gly Leu Phe Asn Ile 
    610                 615                 620                 


Val Tyr Trp Val Tyr His Met Tyr 
625                 630         


<210>  42
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  43
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Gly Leu Leu Ser Gln Gly Ser Pro Leu Ser Trp Glu Glu Thr Lys 
1               5                   10                  15      


Arg His Ala Asp His Val Arg Arg His Gly Ile Leu Gln Phe Leu His 
            20                  25                  30          


Ile Tyr His Ala Val Lys Asp Arg His Lys Asp Val Leu Lys Trp Gly 
        35                  40                  45              


Asp Glu Val Glu Tyr Met Leu Val Ser Phe Asp His Glu Asn Lys Lys 
    50                  55                  60                  


Val Arg Leu Val Leu Ser Gly Glu Lys Val Leu Glu Thr Leu Gln Glu 
65                  70                  75                  80  


Lys Gly Glu Arg Thr Asn Pro Asn His Pro Thr Leu Trp Arg Pro Glu 
                85                  90                  95      


Tyr Gly Ser Tyr Met Ile Glu Gly Thr Pro Gly Gln Pro Tyr Gly Gly 
            100                 105                 110         


Thr Met Ser Glu Phe Asn Thr Val Glu Ala Asn Met Arg Lys Arg Arg 
        115                 120                 125             


Lys Glu Ala Thr Ser Ile Leu Glu Glu Asn Gln Ala Leu Cys Thr Ile 
    130                 135                 140                 


Thr Ser Phe Pro Arg Leu Gly Cys Pro Gly Phe Thr Leu Pro Glu Val 
145                 150                 155                 160 


Lys Pro Asn Pro Val Glu Gly Gly Ala Ser Lys Ser Leu Phe Phe Pro 
                165                 170                 175     


Asp Glu Ala Ile Asn Lys His Pro Arg Phe Ser Thr Leu Thr Arg Asn 
            180                 185                 190         


Ile Arg His Arg Arg Gly Glu Lys Val Val Ile Asn Val Pro Ile Phe 
        195                 200                 205             


Lys Asp Lys Asn Thr Pro Ser Pro Phe Ile Glu Thr Phe Thr Glu Asp 
    210                 215                 220                 


Asp Glu Ala Ser Arg Ala Ser Lys Pro Asp His Ile Tyr Met Asp Ala 
225                 230                 235                 240 


Met Gly Phe Gly Met Gly Asn Cys Cys Leu Gln Val Thr Phe Gln Ala 
                245                 250                 255     


Cys Ser Ile Ser Glu Ala Arg Tyr Leu Tyr Asp Gln Leu Ala Thr Ile 
            260                 265                 270         


Cys Pro Ile Val Met Ala Leu Ser Ala Ala Ser Pro Phe Tyr Arg Gly 
        275                 280                 285             


Tyr Val Ser Asp Ile Asp Cys Arg Trp Gly Val Ile Ser Ala Ser Val 
    290                 295                 300                 


Asp Asp Arg Thr Arg Glu Glu Arg Gly Leu Glu Pro Leu Lys Asn Asn 
305                 310                 315                 320 


Asn Tyr Arg Ile Ser Lys Ser Arg Tyr Asp Ser Ile Asp Ser Tyr Leu 
                325                 330                 335     


Ser Lys Cys Gly Glu Lys Tyr Asn Asp Ile Asp Leu Thr Ile Asp Lys 
            340                 345                 350         


Glu Ile Tyr Glu Gln Leu Leu Gln Glu Gly Ile Asp His Leu Leu Ala 
        355                 360                 365             


Gln His Val Ala His Leu Phe Ile Arg Asp Pro Leu Thr Leu Phe Glu 
    370                 375                 380                 


Glu Lys Ile His Leu Asp Asp Ala Asn Glu Ser Asp His Phe Glu Asn 
385                 390                 395                 400 


Ile Gln Ser Thr Asn Trp Gln Thr Met Arg Phe Lys Pro Pro Pro Pro 
                405                 410                 415     


Asn Ser Asp Ile Gly Trp Arg Val Glu Phe Arg Pro Met Glu Val Gln 
            420                 425                 430         


Leu Thr Asp Phe Glu Asn Ser Ala Tyr Val Val Phe Val Val Leu Leu 
        435                 440                 445             


Thr Arg Val Ile Leu Ser Tyr Lys Leu Asp Phe Leu Ile Pro Leu Ser 
    450                 455                 460                 


Lys Val Asp Glu Asn Met Lys Val Ala Gln Lys Arg Asp Ala Val Leu 
465                 470                 475                 480 


Gln Gly Met Phe Tyr Phe Arg Lys Asp Ile Cys Lys Gly Gly Asn Ala 
                485                 490                 495     


Val Val Asp Gly Cys Gly Lys Ala Gln Asn Ser Thr Glu Leu Ala Ala 
            500                 505                 510         


Glu Glu Tyr Thr Leu Met Ser Ile Asp Thr Ile Ile Asn Gly Lys Glu 
        515                 520                 525             


Gly Val Phe Pro Gly Leu Ile Pro Ile Leu Asn Ser Tyr Leu Glu Asn 
    530                 535                 540                 


Met Glu Val Asp Val Asp Thr Arg Cys Ser Ile Leu Asn Tyr Leu Lys 
545                 550                 555                 560 


Leu Ile Lys Lys Arg Ala Ser Gly Glu Leu Met Thr Val Ala Arg Trp 
                565                 570                 575     


Met Arg Glu Phe Ile Ala Asn His Pro Asp Tyr Lys Gln Asp Ser Val 
            580                 585                 590         


Ile Thr Asp Glu Met Asn Tyr Ser Leu Ile Leu Lys Cys Asn Gln Ile 
        595                 600                 605             


Ala Asn Glu Leu Cys Glu Cys Pro Glu Leu Leu Gly Ser Ala Phe Arg 
    610                 615                 620                 


Lys Val Lys Tyr Ser Gly Ser Lys Thr Asp Ser Ser Asn 
625                 630                 635         


<210>  44
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210>  45
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  46
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Glu Arg Ala Ala Leu Glu Glu Leu Val Lys Leu Gln Gly Glu 
1               5                   10                  15      


Arg Val Arg Gly Leu Lys Gln Gln Lys Ala Ser Ala Glu Leu Ile Glu 
            20                  25                  30          


Glu Glu Val Ala Lys Leu Leu Lys Leu Lys Ala Gln Leu Gly Pro Asp 
        35                  40                  45              


Glu Ser Lys Gln Lys Phe Val Leu Lys Thr Pro Lys Gly Thr Arg Asp 
    50                  55                  60                  


Tyr Ser Pro Arg Gln Met Ala Val Arg Glu Lys Val Phe Asp Val Ile 
65                  70                  75                  80  


Ile Arg Cys Phe Lys Arg His Gly Ala Glu Val Ile Asp Thr Pro Val 
                85                  90                  95      


Phe Glu Leu Lys Glu Thr Leu Met Gly Lys Tyr Gly Glu Asp Ser Lys 
            100                 105                 110         


Leu Ile Tyr Asp Leu Lys Asp Gln Gly Gly Glu Leu Leu Ser Leu Arg 
        115                 120                 125             


Tyr Asp Leu Thr Val Pro Phe Ala Arg Tyr Leu Ala Met Asn Lys Leu 
    130                 135                 140                 


Thr Asn Ile Lys Arg Tyr His Ile Ala Lys Val Tyr Arg Arg Asp Asn 
145                 150                 155                 160 


Pro Ala Met Thr Arg Gly Arg Tyr Arg Glu Phe Tyr Gln Cys Asp Phe 
                165                 170                 175     


Asp Ile Ala Gly Asn Phe Asp Pro Met Ile Pro Asp Ala Glu Cys Leu 
            180                 185                 190         


Lys Ile Met Cys Glu Ile Leu Ser Ser Leu Gln Ile Gly Asp Phe Leu 
        195                 200                 205             


Val Lys Val Asn Asp Arg Arg Ile Leu Asp Gly Met Phe Ala Ile Cys 
    210                 215                 220                 


Gly Val Ser Asp Ser Lys Phe Arg Thr Ile Cys Ser Ser Val Asp Lys 
225                 230                 235                 240 


Leu Asp Lys Val Ser Trp Glu Glu Val Lys Asn Glu Met Val Gly Glu 
                245                 250                 255     


Lys Gly Leu Ala Pro Glu Val Ala Asp Arg Ile Gly Asp Tyr Val Gln 
            260                 265                 270         


Gln His Gly Gly Val Ser Leu Val Glu Gln Leu Leu Gln Asp Pro Lys 
        275                 280                 285             


Leu Ser Gln Asn Lys Gln Ala Leu Glu Gly Leu Gly Asp Leu Lys Leu 
    290                 295                 300                 


Leu Phe Glu Tyr Leu Thr Leu Phe Gly Ile Asp Asp Lys Ile Ser Phe 
305                 310                 315                 320 


Asp Leu Ser Leu Ala Arg Gly Leu Asp Tyr Tyr Thr Gly Val Ile Tyr 
                325                 330                 335     


Glu Ala Val Leu Leu Gln Thr Pro Ala Gln Ala Gly Glu Glu Pro Leu 
            340                 345                 350         


Gly Val Gly Ser Val Ala Ala Gly Gly Arg Tyr Asp Gly Leu Val Gly 
        355                 360                 365             


Met Phe Asp Pro Lys Gly Arg Lys Val Pro Cys Val Gly Leu Ser Ile 
    370                 375                 380                 


Gly Val Glu Arg Ile Phe Ser Ile Val Glu Gln Arg Leu Glu Ala Leu 
385                 390                 395                 400 


Glu Glu Lys Ile Arg Thr Thr Glu Thr Gln Val Leu Val Ala Ser Ala 
                405                 410                 415     


Gln Lys Lys Leu Leu Glu Glu Arg Leu Lys Leu Val Ser Glu Leu Trp 
            420                 425                 430         


Asp Ala Gly Ile Lys Ala Glu Leu Leu Tyr Lys Lys Asn Pro Lys Leu 
        435                 440                 445             


Leu Asn Gln Leu Gln Tyr Cys Glu Glu Ala Gly Ile Pro Leu Val Ala 
    450                 455                 460                 


Ile Ile Gly Glu Gln Glu Leu Lys Asp Gly Val Ile Lys Leu Arg Ser 
465                 470                 475                 480 


Val Thr Ser Arg Glu Glu Val Asp Val Arg Arg Glu Asp Leu Val Glu 
                485                 490                 495     


Glu Ile Lys Arg Arg Thr Gly Gln Pro Leu Cys Ile Cys 
            500                 505                 


<210>  47
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
1               5                   10                  15      


Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
            20                  25                  30          


Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
        35                  40                  45              


Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
    50                  55                  60                  


Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn 
                85                  90                  95      


Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln 
            100                 105                 110         


Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
        115                 120                 125             


Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
    130                 135                 140                 


Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                165                 170                 175     


Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
            180                 185                 190         


Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
        195                 200                 205             


Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
    210                 215                 220                 


Val Asn Phe Pro Met Arg Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
225                 230                 235                 240 


Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                245                 250                 255     


Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
            260                 265                 270         


Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
        275                 280                 285             


Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
    290                 295                 300                 


Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
305                 310                 315                 320 


Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                325                 330                 335     


Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
            340                 345                 350         


Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
    370                 375                 380                 


Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
385                 390                 395                 400 


Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                405                 410                 415     


Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
            420                 425                 430         


Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
        435                 440                 445             


Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
    450                 455                 460                 


Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
465                 470                 475                 480 


Lys Ser Glu Gln Leu Ser Asn Pro 
                485             


<210>  48
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Pro Gly Ser Leu Pro Leu Asn Ala Glu Ala Cys Trp Pro Lys Asp 
1               5                   10                  15      


Val Gly Ile Val Ala Leu Glu Ile Tyr Phe Pro Ser Gln Tyr Val Asp 
            20                  25                  30          


Gln Ala Glu Leu Glu Lys Tyr Asp Gly Val Asp Ala Gly Lys Tyr Thr 
        35                  40                  45              


Ile Gly Leu Gly Gln Ala Lys Met Gly Phe Cys Thr Asp Arg Glu Asp 
    50                  55                  60                  


Ile Asn Ser Leu Cys Met Thr Val Val Gln Asn Leu Met Glu Arg Asn 
65                  70                  75                  80  


Asn Leu Ser Tyr Asp Cys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
                85                  90                  95      


Ile Ile Asp Lys Ser Lys Ser Val Lys Thr Asn Leu Met Gln Leu Phe 
            100                 105                 110         


Glu Glu Ser Gly Asn Thr Asp Ile Glu Gly Ile Asp Thr Thr Asn Ala 
        115                 120                 125             


Cys Tyr Gly Gly Thr Ala Ala Val Phe Asn Ala Val Asn Trp Ile Glu 
    130                 135                 140                 


Ser Ser Ser Trp Asp Gly Arg Tyr Ala Leu Val Val Ala Gly Asp Ile 
145                 150                 155                 160 


Ala Val Tyr Ala Thr Gly Asn Ala Arg Pro Thr Gly Gly Val Gly Ala 
                165                 170                 175     


Val Ala Leu Leu Ile Gly Pro Asn Ala Pro Leu Ile Phe Glu Arg Gly 
            180                 185                 190         


Leu Arg Gly Thr His Met Gln His Ala Tyr Asp Phe Tyr Lys Pro Asp 
        195                 200                 205             


Met Leu Ser Glu Tyr Pro Ile Val Asp Gly Lys Leu Ser Ile Gln Cys 
    210                 215                 220                 


Tyr Leu Ser Ala Leu Asp Arg Cys Tyr Ser Val Tyr Cys Lys Lys Ile 
225                 230                 235                 240 


His Ala Gln Trp Gln Lys Glu Gly Asn Asp Lys Asp Phe Thr Leu Asn 
                245                 250                 255     


Asp Phe Gly Phe Met Ile Phe His Ser Pro Tyr Cys Lys Leu Val Gln 
            260                 265                 270         


Lys Ser Leu Ala Arg Met Leu Leu Asn Asp Phe Leu Asn Asp Gln Asn 
        275                 280                 285             


Arg Asp Lys Asn Ser Ile Tyr Ser Gly Leu Glu Ala Phe Gly Asp Val 
    290                 295                 300                 


Lys Leu Glu Asp Thr Tyr Phe Asp Arg Asp Val Glu Lys Ala Phe Met 
305                 310                 315                 320 


Lys Ala Ser Ser Glu Leu Phe Ser Gln Lys Thr Lys Ala Ser Leu Leu 
                325                 330                 335     


Val Ser Asn Gln Asn Gly Asn Met Tyr Thr Ser Ser Val Tyr Gly Ser 
            340                 345                 350         


Leu Ala Ser Val Leu Ala Gln Tyr Ser Pro Gln Gln Leu Ala Gly Lys 
        355                 360                 365             


Arg Ile Gly Val Phe Ser Tyr Gly Ser Gly Leu Ala Ala Thr Leu Tyr 
    370                 375                 380                 


Ser Leu Lys Val Thr Gln Asp Ala Thr Pro Gly Ser Ala Leu Asp Lys 
385                 390                 395                 400 


Ile Thr Ala Ser Leu Cys Asp Leu Lys Ser Arg Leu Asp Ser Arg Thr 
                405                 410                 415     


Gly Val Ala Pro Asp Val Phe Ala Glu Asn Met Lys Leu Arg Glu Asp 
            420                 425                 430         


Thr His His Leu Val Asn Tyr Ile Pro Gln Gly Ser Ile Asp Ser Leu 
        435                 440                 445             


Phe Glu Gly Thr Trp Tyr Leu Val Arg Val Asp Glu Lys His Arg Arg 
    450                 455                 460                 


Thr Tyr Ala Arg Arg Pro Thr Pro Asn Asp Asp Thr Leu Asp Glu Gly 
465                 470                 475                 480 


Val Gly Leu Val His Ser Asn Ile Ala Thr Glu His Ile Pro Ser Pro 
                485                 490                 495     


Ala Lys Lys Val Pro Arg Leu Pro Ala Thr Ala Ala Glu Pro Glu Ala 
            500                 505                 510         


Ala Val Ile Ser Asn Gly Glu His 
        515                 520 


<210>  49
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Glu Glu Val His His Gly Glu Glu Glu Val Glu Thr Phe Ala 
1               5                   10                  15      


Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu Ile Ile Asn Thr Phe 
            20                  25                  30          


Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser 
        35                  40                  45              


Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu Thr Asp Pro Ser Lys 
    50                  55                  60                  


Leu Asp Ser Gly Lys Glu Leu Lys Ile Asp Ile Ile Pro Asn Pro Gln 
65                  70                  75                  80  


Glu Arg Thr Leu Thr Leu Val Asp Thr Gly Ile Gly Met Thr Lys Ala 
                85                  90                  95      


Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Lys Ala 
            100                 105                 110         


Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile Ser Met Ile Gly Gln 
        115                 120                 125             


Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val Ala Glu Lys Val Val 
    130                 135                 140                 


Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr Ala Trp Glu Ser Ser 
145                 150                 155                 160 


Ala Gly Gly Ser Phe Thr Val Arg Ala Asp His Gly Glu Pro Ile Gly 
                165                 170                 175     


Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu Asp Gln Thr Glu Tyr 
            180                 185                 190         


Leu Glu Glu Arg Arg Val Lys Glu Val Val Lys Lys His Ser Gln Phe 
        195                 200                 205             


Ile Gly Tyr Pro Ile Thr Leu Tyr Leu Glu Lys Glu Arg Glu Lys Glu 
    210                 215                 220                 


Ile Ser Asp Asp Glu Ala Glu Glu Glu Lys Gly Glu Lys Glu Glu Glu 
225                 230                 235                 240 


Asp Lys Asp Asp Glu Glu Lys Pro Lys Ile Glu Asp Val Gly Ser Asp 
                245                 250                 255     


Glu Glu Asp Asp Ser Gly Lys Asp Lys Lys Lys Lys Thr Lys Lys Ile 
            260                 265                 270         


Lys Glu Lys Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile 
        275                 280                 285             


Trp Thr Arg Asn Pro Asp Asp Ile Thr Gln Glu Glu Tyr Gly Glu Phe 
    290                 295                 300                 


Tyr Lys Ser Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His 
305                 310                 315                 320 


Phe Ser Val Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Ile Pro 
                325                 330                 335     


Arg Arg Ala Pro Phe Asp Leu Phe Glu Asn Lys Lys Lys Lys Asn Asn 
            340                 345                 350         


Ile Lys Leu Tyr Val Arg Arg Val Phe Ile Met Asp Ser Cys Asp Glu 
        355                 360                 365             


Leu Ile Pro Glu Tyr Leu Asn Phe Ile Arg Gly Val Val Asp Ser Glu 
    370                 375                 380                 


Asp Leu Pro Leu Asn Ile Ser Arg Glu Met Leu Gln Gln Ser Lys Ile 
385                 390                 395                 400 


Leu Lys Val Ile Arg Lys Asn Ile Val Lys Lys Cys Leu Glu Leu Phe 
                405                 410                 415     


Ser Glu Leu Ala Glu Asp Lys Glu Asn Tyr Lys Lys Phe Tyr Glu Ala 
            420                 425                 430         


Phe Ser Lys Asn Leu Lys Leu Gly Ile His Glu Asp Ser Thr Asn Arg 
        435                 440                 445             


Arg Arg Leu Ser Glu Leu Leu Arg Tyr His Thr Ser Gln Ser Gly Asp 
    450                 455                 460                 


Glu Met Thr Ser Leu Ser Glu Tyr Val Ser Arg Met Lys Glu Thr Gln 
465                 470                 475                 480 


Lys Ser Ile Tyr Tyr Ile Thr Gly Glu Ser Lys Glu Gln Val Ala Asn 
                485                 490                 495     


Ser Ala Phe Val Glu Arg Val Arg Lys Arg Gly Phe Glu Val Val Tyr 
            500                 505                 510         


Met Thr Glu Pro Ile Asp Glu Tyr Cys Val Gln Gln Leu Lys Glu Phe 
        515                 520                 525             


Asp Gly Lys Ser Leu Val Ser Val Thr Lys Glu Gly Leu Glu Leu Pro 
    530                 535                 540                 


Glu Asp Glu Glu Glu Lys Lys Lys Met Glu Glu Ser Lys Ala Lys Phe 
545                 550                 555                 560 


Glu Asn Leu Cys Lys Leu Met Lys Glu Ile Leu Asp Lys Lys Val Glu 
                565                 570                 575     


Lys Val Thr Ile Ser Asn Arg Leu Val Ser Ser Pro Cys Cys Ile Val 
            580                 585                 590         


Thr Ser Thr Tyr Gly Trp Thr Ala Asn Met Glu Arg Ile Met Lys Ala 
        595                 600                 605             


Gln Ala Leu Arg Asp Asn Ser Thr Met Gly Tyr Met Met Ala Lys Lys 
    610                 615                 620                 


His Leu Glu Ile Asn Pro Asp His Pro Ile Val Glu Thr Leu Arg Gln 
625                 630                 635                 640 


Lys Ala Glu Ala Asp Lys Asn Asp Lys Ala Val Lys Asp Leu Val Val 
                645                 650                 655     


Leu Leu Phe Glu Thr Ala Leu Leu Ser Ser Gly Phe Ser Leu Glu Asp 
            660                 665                 670         


Pro Gln Thr His Ser Asn Arg Ile Tyr Arg Met Ile Lys Leu Gly Leu 
        675                 680                 685             


Gly Ile Asp Glu Asp Glu Val Ala Ala Glu Glu Pro Asn Ala Ala Val 
    690                 695                 700                 


Pro Asp Glu Ile Pro Pro Leu Glu Gly Asp Glu Asp Ala Ser Arg Met 
705                 710                 715                 720 


Glu Glu Val Asp 
                


<210>  50
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Arg Trp Gly Leu Arg Pro Arg Gly Pro Gly Ala Ala Ala Leu Ala 
1               5                   10                  15      


Thr Ala Arg Ser Leu Trp Gly Thr Pro Arg Leu Pro Cys Ser Pro Gly 
            20                  25                  30          


Trp Gln Gly Ala Thr Lys Arg Leu Leu Val Arg Ser Val Ser Gly Ala 
        35                  40                  45              


Ser Asn His Gln Pro Asn Ser Asn Ser Gly Arg Tyr Arg Asp Thr Val 
    50                  55                  60                  


Leu Leu Pro Gln Thr Ser Phe Pro Met Lys Leu Leu Gly Arg Gln Gln 
65                  70                  75                  80  


Pro Asp Thr Glu Leu Glu Ile Gln Gln Lys Cys Gly Phe Ser Glu Leu 
                85                  90                  95      


Tyr Ser Trp Gln Arg Glu Arg Lys Val Lys Thr Glu Phe Cys Leu His 
            100                 105                 110         


Asp Gly Pro Pro Tyr Ala Asn Gly Asp Pro His Val Gly His Ala Leu 
        115                 120                 125             


Asn Lys Ile Leu Lys Asp Ile Ala Asn Arg Phe His Met Met Asn Gly 
    130                 135                 140                 


Ser Lys Ile His Phe Val Pro Gly Trp Asp Cys His Gly Leu Pro Ile 
145                 150                 155                 160 


Glu Ile Lys Val Leu Ser Glu Leu Gly Arg Glu Ala Gln Asn Leu Ser 
                165                 170                 175     


Ala Met Glu Ile Arg Lys Lys Ala Arg Ser Phe Ala Lys Ala Ala Ile 
            180                 185                 190         


Glu Lys Gln Lys Ser Ala Phe Ile Arg Trp Gly Ile Met Ala Asp Trp 
        195                 200                 205             


Asn Asn Cys Tyr Tyr Thr Phe Asp Gly Lys Tyr Glu Ala Lys Gln Leu 
    210                 215                 220                 


Arg Thr Phe Tyr Gln Met Tyr Asp Lys Gly Leu Val Tyr Arg Ser Tyr 
225                 230                 235                 240 


Lys Pro Val Phe Trp Ser Pro Ser Ser Arg Thr Ala Leu Ala Glu Ala 
                245                 250                 255     


Glu Leu Glu Tyr Asn Pro Glu His Val Ser Arg Ser Ile Tyr Val Lys 
            260                 265                 270         


Phe Pro Leu Leu Lys Pro Ser Pro Lys Leu Ala Ser Leu Ile Asp Gly 
        275                 280                 285             


Ser Ser Pro Val Ser Ile Leu Val Trp Thr Thr Gln Pro Trp Thr Ile 
    290                 295                 300                 


Pro Ala Asn Glu Ala Val Cys Tyr Met Pro Glu Ser Lys Tyr Ala Val 
305                 310                 315                 320 


Val Lys Cys Ser Lys Ser Gly Asp Leu Tyr Val Leu Ala Ala Asp Lys 
                325                 330                 335     


Val Ala Ser Val Ala Ser Thr Leu Glu Thr Thr Phe Glu Thr Ile Ser 
            340                 345                 350         


Thr Leu Ser Gly Val Asp Leu Glu Asn Gly Thr Cys Ser His Pro Leu 
        355                 360                 365             


Ile Pro Asp Lys Ala Ser Pro Leu Leu Pro Ala Asn His Val Thr Met 
    370                 375                 380                 


Ala Lys Gly Thr Gly Leu Val His Thr Ala Pro Ala His Gly Met Glu 
385                 390                 395                 400 


Asp Tyr Gly Val Ala Ser Gln His Asn Leu Pro Met Asp Cys Leu Val 
                405                 410                 415     


Asp Glu Asp Gly Val Phe Thr Asp Val Ala Gly Pro Glu Leu Gln Asn 
            420                 425                 430         


Lys Ala Val Leu Glu Glu Gly Thr Asp Val Val Ile Lys Met Leu Gln 
        435                 440                 445             


Thr Ala Lys Asn Leu Leu Lys Glu Glu Lys Leu Val His Ser Tyr Pro 
    450                 455                 460                 


Tyr Asp Trp Arg Thr Lys Lys Pro Val Val Ile Arg Ala Ser Lys Gln 
465                 470                 475                 480 


Trp Phe Ile Asn Ile Thr Asp Ile Lys Thr Ala Ala Lys Glu Leu Leu 
                485                 490                 495     


Lys Lys Val Lys Phe Ile Pro Gly Ser Ala Leu Asn Gly Met Val Glu 
            500                 505                 510         


Met Met Asp Arg Arg Pro Tyr Trp Cys Ile Ser Arg Gln Arg Val Trp 
        515                 520                 525             


Gly Val Pro Ile Pro Val Phe His His Lys Thr Lys Asp Glu Tyr Leu 
    530                 535                 540                 


Ile Asn Ser Gln Thr Thr Glu His Ile Val Lys Leu Val Glu Gln His 
545                 550                 555                 560 


Gly Ser Asp Ile Trp Trp Thr Leu Pro Pro Glu Gln Leu Leu Pro Lys 
                565                 570                 575     


Glu Val Leu Ser Glu Val Gly Gly Pro Asp Ala Leu Glu Tyr Val Pro 
            580                 585                 590         


Gly Gln Asp Ile Leu Asp Ile Trp Phe Asp Ser Gly Thr Ser Trp Ser 
        595                 600                 605             


Tyr Val Leu Pro Gly Pro Asp Gln Arg Ala Asp Leu Tyr Leu Glu Gly 
    610                 615                 620                 


Lys Asp Gln Leu Gly Gly Trp Phe Gln Ser Ser Leu Leu Thr Ser Val 
625                 630                 635                 640 


Ala Ala Arg Lys Arg Ala Pro Tyr Lys Thr Val Ile Val His Gly Phe 
                645                 650                 655     


Thr Leu Gly Glu Lys Gly Glu Lys Met Ser Lys Ser Leu Gly Asn Val 
            660                 665                 670         


Ile His Pro Asp Val Val Val Asn Gly Gly Gln Asp Gln Ser Lys Glu 
        675                 680                 685             


Pro Pro Tyr Gly Ala Asp Val Leu Arg Trp Trp Val Ala Asp Ser Asn 
    690                 695                 700                 


Val Phe Thr Glu Val Ala Ile Gly Pro Ser Val Leu Asn Ala Ala Arg 
705                 710                 715                 720 


Asp Asp Ile Ser Lys Leu Arg Asn Thr Leu Arg Phe Leu Leu Gly Asn 
                725                 730                 735     


Val Ala Asp Phe Asn Pro Glu Thr Asp Ser Ile Pro Val Asn Asp Met 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Met Leu His Leu Leu Gln Asp Leu Ala Asn 
        755                 760                 765             


Lys Ile Thr Glu Leu Tyr Lys Gln Tyr Asp Phe Gly Lys Val Val Arg 
    770                 775                 780                 


Leu Leu Arg Thr Phe Tyr Thr Arg Glu Leu Ser Asn Phe Tyr Phe Ser 
785                 790                 795                 800 


Ile Ile Lys Asp Arg Leu Tyr Cys Glu Lys Glu Asn Asp Pro Lys Arg 
                805                 810                 815     


Arg Ser Cys Gln Thr Ala Leu Val Glu Ile Leu Asp Val Ile Val Arg 
            820                 825                 830         


Ser Phe Ala Pro Ile Leu Pro His Leu Ala Glu Glu Val Phe Gln His 
        835                 840                 845             


Ile Pro Tyr Ile Lys Glu Pro Lys Ser Val Phe Arg Thr Gly Trp Ile 
    850                 855                 860                 


Ser Thr Ser Ser Ile Trp Lys Lys Pro Gly Leu Glu Glu Ala Val Glu 
865                 870                 875                 880 


Ser Ala Cys Ala Met Arg Asp Ser Phe Leu Gly Ser Ile Pro Gly Lys 
                885                 890                 895     


Asn Ala Ala Glu Tyr Lys Val Ile Thr Val Ile Glu Pro Gly Leu Leu 
            900                 905                 910         


Phe Glu Ile Ile Glu Met Leu Gln Ser Glu Glu Thr Ser Ser Thr Ser 
        915                 920                 925             


Gln Leu Asn Glu Leu Met Met Ala Ser Glu Ser Thr Leu Leu Ala Gln 
    930                 935                 940                 


Glu Pro Arg Glu Met Thr Ala Asp Val Ile Glu Leu Lys Gly Lys Phe 
945                 950                 955                 960 


Leu Ile Asn Leu Glu Gly Gly Asp Ile Arg Glu Glu Ser Ser Tyr Lys 
                965                 970                 975     


Val Ile Val Met Pro Thr Thr Lys Glu Lys Cys Pro Arg Cys Trp Lys 
            980                 985                 990         


Tyr Thr Ala Glu Ser Ser Asp Thr  Leu Cys Pro Arg Cys  Ala Glu Val 
        995                 1000                 1005             


Val Ser  Gly Lys 
    1010         


<210>  51
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Ala Val Gln Ala Ala Glu Val Lys Val Asp Gly Ser Glu Pro 
1               5                   10                  15      


Lys Leu Ser Lys Asn Glu Leu Lys Arg Arg Leu Lys Ala Glu Lys Lys 
            20                  25                  30          


Val Ala Glu Lys Glu Ala Lys Gln Lys Glu Leu Ser Glu Lys Gln Leu 
        35                  40                  45              


Ser Gln Ala Thr Ala Ala Ala Thr Asn His Thr Thr Asp Asn Gly Val 
    50                  55                  60                  


Gly Pro Glu Glu Glu Ser Val Asp Pro Asn Gln Tyr Tyr Lys Ile Arg 
65                  70                  75                  80  


Ser Gln Ala Ile His Gln Leu Lys Val Asn Gly Glu Asp Pro Tyr Pro 
                85                  90                  95      


His Lys Phe His Val Asp Ile Ser Leu Thr Asp Phe Ile Gln Lys Tyr 
            100                 105                 110         


Ser His Leu Gln Pro Gly Asp His Leu Thr Asp Ile Thr Leu Lys Val 
        115                 120                 125             


Ala Gly Arg Ile His Ala Lys Arg Ala Ser Gly Gly Lys Leu Ile Phe 
    130                 135                 140                 


Tyr Asp Leu Arg Gly Glu Gly Val Lys Leu Gln Val Met Ala Asn Ser 
145                 150                 155                 160 


Arg Asn Tyr Lys Ser Glu Glu Glu Phe Ile His Ile Asn Asn Lys Leu 
                165                 170                 175     


Arg Arg Gly Asp Ile Ile Gly Val Gln Gly Asn Pro Gly Lys Thr Lys 
            180                 185                 190         


Lys Gly Glu Leu Ser Ile Ile Pro Tyr Glu Ile Thr Leu Leu Ser Pro 
        195                 200                 205             


Cys Leu His Met Leu Pro His Leu His Phe Gly Leu Lys Asp Lys Glu 
    210                 215                 220                 


Thr Arg Tyr Arg Gln Arg Tyr Leu Asp Leu Ile Leu Asn Asp Phe Val 
225                 230                 235                 240 


Arg Gln Lys Phe Ile Ile Arg Ser Lys Ile Ile Thr Tyr Ile Arg Ser 
                245                 250                 255     


Phe Leu Asp Glu Leu Gly Phe Leu Glu Ile Glu Thr Pro Met Met Asn 
            260                 265                 270         


Ile Ile Pro Gly Gly Ala Val Ala Lys Pro Phe Ile Thr Tyr His Asn 
        275                 280                 285             


Glu Leu Asp Met Asn Leu Tyr Met Arg Ile Ala Pro Glu Leu Tyr His 
    290                 295                 300                 


Lys Met Leu Val Val Gly Gly Ile Asp Arg Val Tyr Glu Ile Gly Arg 
305                 310                 315                 320 


Gln Phe Arg Asn Glu Gly Ile Asp Leu Thr His Asn Pro Glu Phe Thr 
                325                 330                 335     


Thr Cys Glu Phe Tyr Met Ala Tyr Ala Asp Tyr His Asp Leu Met Glu 
            340                 345                 350         


Ile Thr Glu Lys Met Val Ser Gly Met Val Lys His Ile Thr Gly Ser 
        355                 360                 365             


Tyr Lys Val Thr Tyr His Pro Asp Gly Pro Glu Gly Gln Ala Tyr Asp 
    370                 375                 380                 


Val Asp Phe Thr Pro Pro Phe Arg Arg Ile Asn Met Val Glu Glu Leu 
385                 390                 395                 400 


Glu Lys Ala Leu Gly Met Lys Leu Pro Glu Thr Asn Leu Phe Glu Thr 
                405                 410                 415     


Glu Glu Thr Arg Lys Ile Leu Asp Asp Ile Cys Val Ala Lys Ala Val 
            420                 425                 430         


Glu Cys Pro Pro Pro Arg Thr Thr Ala Arg Leu Leu Asp Lys Leu Val 
        435                 440                 445             


Gly Glu Phe Leu Glu Val Thr Cys Ile Asn Pro Thr Phe Ile Cys Asp 
    450                 455                 460                 


His Pro Gln Ile Met Ser Pro Leu Ala Lys Trp His Arg Ser Lys Glu 
465                 470                 475                 480 


Gly Leu Thr Glu Arg Phe Glu Leu Phe Val Met Lys Lys Glu Ile Cys 
                485                 490                 495     


Asn Ala Tyr Thr Glu Leu Asn Asp Pro Met Arg Gln Arg Gln Leu Phe 
            500                 505                 510         


Glu Glu Gln Ala Lys Ala Lys Ala Ala Gly Asp Asp Glu Ala Met Phe 
        515                 520                 525             


Ile Asp Glu Asn Phe Cys Thr Ala Leu Glu Tyr Gly Leu Pro Pro Thr 
    530                 535                 540                 


Ala Gly Trp Gly Met Gly Ile Asp Arg Val Ala Met Phe Leu Thr Asp 
545                 550                 555                 560 


Ser Asn Asn Ile Lys Glu Val Leu Leu Phe Pro Ala Met Lys Pro Glu 
                565                 570                 575     


Asp Lys Lys Glu Asn Val Ala Thr Thr Asp Thr Leu Glu Ser Thr Thr 
            580                 585                 590         


Val Gly Thr Ser Val 
        595         


<210>  52
<211>  1162
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Pro Glu Glu Glu Arg Ile Arg Tyr Ser Gln Arg Leu Arg Gly 
1               5                   10                  15      


Thr Met Arg Arg Arg Tyr Glu Asp Asp Gly Ile Ser Asp Asp Glu Ile 
            20                  25                  30          


Glu Gly Lys Arg Thr Phe Asp Leu Glu Glu Lys Leu His Thr Asn Lys 
        35                  40                  45              


Tyr Asn Ala Asn Phe Val Thr Phe Met Glu Gly Lys Asp Phe Asn Val 
    50                  55                  60                  


Glu Tyr Ile Gln Arg Gly Gly Leu Arg Asp Pro Leu Ile Phe Lys Asn 
65                  70                  75                  80  


Ser Asp Gly Leu Gly Ile Lys Met Pro Asp Pro Asp Phe Thr Val Asn 
                85                  90                  95      


Asp Val Lys Met Cys Val Gly Ser Arg Arg Met Val Asp Val Met Asp 
            100                 105                 110         


Val Asn Thr Gln Lys Gly Ile Glu Met Thr Met Ala Gln Trp Thr Arg 
        115                 120                 125             


Tyr Tyr Glu Thr Pro Glu Glu Glu Arg Glu Lys Leu Tyr Asn Val Ile 
    130                 135                 140                 


Ser Leu Glu Phe Ser His Thr Arg Leu Glu Asn Met Val Gln Arg Pro 
145                 150                 155                 160 


Ser Thr Val Asp Phe Ile Asp Trp Val Asp Asn Met Trp Pro Arg His 
                165                 170                 175     


Leu Lys Glu Ser Gln Thr Glu Ser Thr Asn Ala Ile Leu Glu Met Gln 
            180                 185                 190         


Tyr Pro Lys Val Gln Lys Tyr Cys Leu Met Ser Val Arg Gly Cys Tyr 
        195                 200                 205             


Thr Asp Phe His Val Asp Phe Gly Gly Thr Ser Val Trp Tyr His Ile 
    210                 215                 220                 


His Gln Gly Gly Lys Val Phe Trp Leu Ile Pro Pro Thr Ala His Asn 
225                 230                 235                 240 


Leu Glu Leu Tyr Glu Asn Trp Leu Leu Ser Gly Lys Gln Gly Asp Ile 
                245                 250                 255     


Phe Leu Gly Asp Arg Val Ser Asp Cys Gln Arg Ile Glu Leu Lys Gln 
            260                 265                 270         


Gly Tyr Thr Phe Val Ile Pro Ser Gly Trp Ile His Ala Val Tyr Thr 
        275                 280                 285             


Pro Thr Asp Thr Leu Val Phe Gly Gly Asn Phe Leu His Ser Phe Asn 
    290                 295                 300                 


Ile Pro Met Gln Leu Lys Ile Tyr Asn Ile Glu Asp Arg Thr Arg Val 
305                 310                 315                 320 


Pro Asn Lys Phe Arg Tyr Pro Phe Tyr Tyr Glu Met Cys Trp Tyr Val 
                325                 330                 335     


Leu Glu Arg Tyr Val Tyr Cys Ile Thr Asn Arg Ser His Leu Thr Lys 
            340                 345                 350         


Glu Phe Gln Lys Glu Ser Leu Ser Met Asp Leu Glu Leu Asn Gly Leu 
        355                 360                 365             


Glu Ser Gly Asn Gly Asp Glu Glu Ala Val Asp Arg Glu Pro Arg Arg 
    370                 375                 380                 


Leu Ser Ser Arg Arg Ser Val Leu Thr Ser Pro Val Ala Asn Gly Val 
385                 390                 395                 400 


Asn Leu Asp Tyr Asp Gly Leu Gly Lys Thr Cys Arg Ser Leu Pro Ser 
                405                 410                 415     


Leu Lys Lys Thr Leu Ala Gly Asp Ser Ser Ser Asp Cys Ser Arg Gly 
            420                 425                 430         


Ser His Asn Gly Gln Val Trp Asp Pro Gln Cys Ala Pro Arg Lys Asp 
        435                 440                 445             


Arg Gln Val His Leu Thr His Phe Glu Leu Glu Gly Leu Arg Cys Leu 
    450                 455                 460                 


Val Asp Lys Leu Glu Ser Leu Pro Leu His Lys Lys Cys Val Pro Thr 
465                 470                 475                 480 


Gly Ile Glu Asp Glu Asp Ala Leu Ile Ala Asp Val Lys Ile Leu Leu 
                485                 490                 495     


Glu Glu Leu Ala Asn Ser Asp Pro Lys Leu Ala Leu Thr Gly Val Pro 
            500                 505                 510         


Ile Val Gln Trp Pro Lys Arg Asp Lys Leu Lys Phe Pro Thr Arg Pro 
        515                 520                 525             


Lys Val Arg Val Pro Thr Ile Pro Ile Thr Lys Pro His Thr Met Lys 
    530                 535                 540                 


Pro Ala Pro Arg Leu Thr Pro Val Arg Pro Ala Ala Ala Ser Pro Ile 
545                 550                 555                 560 


Val Ser Gly Ala Arg Arg Arg Arg Val Arg Cys Arg Lys Cys Lys Ala 
                565                 570                 575     


Cys Val Gln Gly Glu Cys Gly Val Cys His Tyr Cys Arg Asp Met Lys 
            580                 585                 590         


Lys Phe Gly Gly Pro Gly Arg Met Lys Gln Ser Cys Val Leu Arg Gln 
        595                 600                 605             


Cys Leu Ala Pro Arg Leu Pro His Ser Val Thr Cys Ser Leu Cys Gly 
    610                 615                 620                 


Glu Val Asp Gln Asn Glu Glu Thr Gln Asp Phe Glu Lys Lys Leu Met 
625                 630                 635                 640 


Glu Cys Cys Ile Cys Asn Glu Ile Val His Pro Gly Cys Leu Gln Met 
                645                 650                 655     


Asp Gly Glu Gly Leu Leu Asn Glu Glu Leu Pro Asn Cys Trp Glu Cys 
            660                 665                 670         


Pro Lys Cys Tyr Gln Glu Asp Ser Ser Glu Lys Ala Gln Lys Arg Lys 
        675                 680                 685             


Met Glu Glu Ser Asp Glu Glu Ala Val Gln Ala Lys Val Leu Arg Pro 
    690                 695                 700                 


Leu Arg Ser Cys Asp Glu Pro Leu Thr Pro Pro Pro His Ser Pro Thr 
705                 710                 715                 720 


Ser Met Leu Gln Leu Ile His Asp Pro Val Ser Pro Arg Gly Met Val 
                725                 730                 735     


Thr Arg Ser Ser Pro Gly Ala Gly Pro Ser Asp His His Ser Ala Ser 
            740                 745                 750         


Arg Asp Glu Arg Phe Lys Arg Arg Gln Leu Leu Arg Leu Gln Ala Thr 
        755                 760                 765             


Glu Arg Thr Met Val Arg Glu Lys Glu Asn Asn Pro Ser Gly Lys Lys 
    770                 775                 780                 


Glu Leu Ser Glu Val Glu Lys Ala Lys Ile Arg Gly Ser Tyr Leu Thr 
785                 790                 795                 800 


Val Thr Leu Gln Arg Pro Thr Lys Glu Leu His Gly Thr Ser Ile Val 
                805                 810                 815     


Pro Lys Leu Gln Ala Ile Thr Ala Ser Ser Ala Asn Leu Arg His Ser 
            820                 825                 830         


Pro Arg Val Leu Val Gln His Cys Pro Ala Arg Thr Pro Gln Arg Gly 
        835                 840                 845             


Asp Glu Glu Gly Leu Gly Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu 
    850                 855                 860                 


Glu Glu Asp Asp Ser Ala Glu Glu Gly Gly Ala Ala Arg Leu Asn Gly 
865                 870                 875                 880 


Arg Gly Ser Trp Ala Gln Asp Gly Asp Glu Ser Trp Met Gln Arg Glu 
                885                 890                 895     


Val Trp Met Ser Val Phe Arg Tyr Leu Ser Arg Arg Glu Leu Cys Glu 
            900                 905                 910         


Cys Met Arg Val Cys Lys Thr Trp Tyr Lys Trp Cys Cys Asp Lys Arg 
        915                 920                 925             


Leu Trp Thr Lys Ile Asp Leu Ser Arg Cys Lys Ala Ile Val Pro Gln 
    930                 935                 940                 


Ala Leu Ser Gly Ile Ile Lys Arg Gln Pro Val Ser Leu Asp Leu Ser 
945                 950                 955                 960 


Trp Thr Asn Ile Ser Lys Lys Gln Leu Thr Trp Leu Val Asn Arg Leu 
                965                 970                 975     


Pro Gly Leu Lys Asp Leu Leu Leu Ala Gly Cys Ser Trp Ser Ala Val 
            980                 985                 990         


Ser Ala Leu Ser Thr Ser Ser Cys  Pro Leu Leu Arg Thr  Leu Asp Leu 
        995                 1000                 1005             


Arg Trp  Ala Val Gly Ile Lys  Asp Pro Gln Ile Arg  Asp Leu Leu 
    1010                 1015                 1020             


Thr Pro  Pro Ala Asp Lys Pro  Gly Gln Asp Asn Arg  Ser Lys Leu 
    1025                 1030                 1035             


Arg Asn  Met Thr Asp Phe Arg  Leu Ala Gly Leu Asp  Ile Thr Asp 
    1040                 1045                 1050             


Ala Thr  Leu Arg Leu Ile Ile  Arg His Met Pro Leu  Leu Ser Arg 
    1055                 1060                 1065             


Leu Asp  Leu Ser His Cys Ser  His Leu Thr Asp Gln  Ser Ser Asn 
    1070                 1075                 1080             


Leu Leu  Thr Ala Val Gly Ser  Ser Thr Arg Tyr Ser  Leu Thr Glu 
    1085                 1090                 1095             


Leu Asn  Met Ala Gly Cys Asn  Lys Leu Thr Asp Gln  Thr Leu Ile 
    1100                 1105                 1110             


Tyr Leu  Arg Arg Ile Ala Asn  Val Thr Leu Ile Asp  Leu Arg Gly 
    1115                 1120                 1125             


Cys Lys  Gln Ile Thr Arg Lys  Ala Cys Glu His Phe  Ile Ser Asp 
    1130                 1135                 1140             


Leu Ser  Ile Asn Ser Leu Tyr  Cys Leu Ser Asp Glu  Lys Leu Ile 
    1145                 1150                 1155             


Gln Lys  Ile Ser 
    1160         


<210>  53
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gln Pro Asp Pro Arg Pro Ser Gly Ala Gly Ala Cys Cys Arg Phe 
1               5                   10                  15      


Leu Pro Leu Gln Ser Gln Cys Pro Glu Gly Ala Gly Asp Ala Val Met 
            20                  25                  30          


Tyr Ala Ser Thr Glu Cys Lys Ala Glu Val Thr Pro Ser Gln His Gly 
        35                  40                  45              


Asn Arg Thr Phe Ser Tyr Thr Leu Glu Asp His Thr Lys Gln Ala Phe 
    50                  55                  60                  


Gly Ile Met Asn Glu Leu Arg Leu Ser Gln Gln Leu Cys Asp Val Thr 
65                  70                  75                  80  


Leu Gln Val Lys Tyr Gln Asp Ala Pro Ala Ala Gln Phe Met Ala His 
                85                  90                  95      


Lys Val Val Leu Ala Ser Ser Ser Pro Val Phe Lys Ala Met Phe Thr 
            100                 105                 110         


Asn Gly Leu Arg Glu Gln Gly Met Glu Val Val Ser Ile Glu Gly Ile 
        115                 120                 125             


His Pro Lys Val Met Glu Arg Leu Ile Glu Phe Ala Tyr Thr Ala Ser 
    130                 135                 140                 


Ile Ser Met Gly Glu Lys Cys Val Leu His Val Met Asn Gly Ala Val 
145                 150                 155                 160 


Met Tyr Gln Ile Asp Ser Val Val Arg Ala Cys Ser Asp Phe Leu Val 
                165                 170                 175     


Gln Gln Leu Asp Pro Ser Asn Ala Ile Gly Ile Ala Asn Phe Ala Glu 
            180                 185                 190         


Gln Ile Gly Cys Val Glu Leu His Gln Arg Ala Arg Glu Tyr Ile Tyr 
        195                 200                 205             


Met His Phe Gly Glu Val Ala Lys Gln Glu Glu Phe Phe Asn Leu Ser 
    210                 215                 220                 


His Cys Gln Leu Val Thr Leu Ile Ser Arg Asp Asp Leu Asn Val Arg 
225                 230                 235                 240 


Cys Glu Ser Glu Val Phe His Ala Cys Ile Asn Trp Val Lys Tyr Asp 
                245                 250                 255     


Cys Glu Gln Arg Arg Phe Tyr Val Gln Ala Leu Leu Arg Ala Val Arg 
            260                 265                 270         


Cys His Ser Leu Thr Pro Asn Phe Leu Gln Met Gln Leu Gln Lys Cys 
        275                 280                 285             


Glu Ile Leu Gln Ser Asp Ser Arg Cys Lys Asp Tyr Leu Val Lys Ile 
    290                 295                 300                 


Phe Glu Glu Leu Thr Leu His Lys Pro Thr Gln Val Met Pro Cys Arg 
305                 310                 315                 320 


Ala Pro Lys Val Gly Arg Leu Ile Tyr Thr Ala Gly Gly Tyr Phe Arg 
                325                 330                 335     


Gln Ser Leu Ser Tyr Leu Glu Ala Tyr Asn Pro Ser Asp Gly Thr Trp 
            340                 345                 350         


Leu Arg Leu Ala Asp Leu Gln Val Pro Arg Ser Gly Leu Ala Gly Cys 
        355                 360                 365             


Val Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Arg Asn Asn Ser Pro 
    370                 375                 380                 


Asp Gly Asn Thr Asp Ser Ser Ala Leu Asp Cys Tyr Asn Pro Met Thr 
385                 390                 395                 400 


Asn Gln Trp Ser Pro Cys Ala Pro Met Ser Val Pro Arg Asn Arg Ile 
                405                 410                 415     


Gly Val Gly Val Ile Asp Gly His Ile Tyr Ala Val Gly Gly Ser His 
            420                 425                 430         


Gly Cys Ile His His Asn Ser Val Glu Arg Tyr Glu Pro Glu Arg Asp 
        435                 440                 445             


Glu Trp His Leu Val Ala Pro Met Leu Thr Arg Arg Ile Gly Val Gly 
    450                 455                 460                 


Val Ala Val Leu Asn Arg Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly 
465                 470                 475                 480 


Thr Asn Arg Leu Asn Ser Ala Glu Cys Tyr Tyr Pro Glu Arg Asn Glu 
                485                 490                 495     


Trp Arg Met Ile Thr Ala Met Asn Thr Ile Arg Ser Gly Ala Gly Val 
            500                 505                 510         


Cys Val Leu His Asn Cys Ile Tyr Ala Ala Gly Gly Tyr Asp Gly Gln 
        515                 520                 525             


Asp Gln Leu Asn Ser Val Glu Arg Tyr Asp Val Glu Thr Glu Thr Trp 
    530                 535                 540                 


Thr Phe Val Ala Pro Met Lys His Arg Arg Ser Ala Leu Gly Ile Thr 
545                 550                 555                 560 


Val His Gln Gly Arg Ile Tyr Val Leu Gly Gly Tyr Asp Gly His Thr 
                565                 570                 575     


Phe Leu Asp Ser Val Glu Cys Tyr Asp Pro Asp Thr Asp Thr Trp Ser 
            580                 585                 590         


Glu Val Thr Arg Met Thr Ser Gly Arg Ser Gly Val Gly Val Ala Val 
        595                 600                 605             


Thr Met Glu Pro Cys Arg Lys Gln Ile Asp Gln Gln Asn Cys Thr Cys 
    610                 615                 620                 


<210>  54
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Met Asp Ser Ser Leu Gln Ala Arg Leu Phe Pro Gly Leu Ala 
1               5                   10                  15      


Ile Lys Ile Gln Arg Ser Asn Gly Leu Ile His Ser Ala Asn Val Arg 
            20                  25                  30          


Thr Val Asn Leu Glu Lys Ser Cys Val Ser Val Glu Trp Ala Glu Gly 
        35                  40                  45              


Gly Ala Thr Lys Gly Lys Glu Ile Asp Phe Asp Asp Val Ala Ala Ile 
    50                  55                  60                  


Asn Pro Glu Leu Leu Gln Leu Leu Pro Leu His Pro Lys Asp Asn Leu 
65                  70                  75                  80  


Pro Leu Gln Glu Asn Val Thr Ile Gln Lys Gln Lys Arg Arg Ser Val 
                85                  90                  95      


Asn Ser Lys Ile Pro Ala Pro Lys Glu Ser Leu Arg Ser Arg Ser Thr 
            100                 105                 110         


Arg Met Ser Thr Val Ser Glu Leu Arg Ile Thr Ala Gln Glu Asn Asp 
        115                 120                 125             


Met Glu Val Glu Leu Pro Ala Ala Ala Asn Ser Arg Lys Gln Phe Ser 
    130                 135                 140                 


Val Pro Pro Ala Pro Thr Arg Pro Ser Cys Pro Ala Val Ala Glu Ile 
145                 150                 155                 160 


Pro Leu Arg Met Val Ser Glu Glu Met Glu Glu Gln Val His Ser Ile 
                165                 170                 175     


Arg Gly Ser Ser Ser Ala Asn Pro Val Asn Ser Val Arg Arg Lys Ser 
            180                 185                 190         


Cys Leu Val Lys Glu Val Glu Lys Met Lys Asn Lys Arg Glu Glu Lys 
        195                 200                 205             


Lys Ala Gln Asn Ser Glu Met Arg Met Lys Arg Ala Gln Glu Tyr Asp 
    210                 215                 220                 


Ser Ser Phe Pro Asn Trp Glu Phe Ala Arg Met Ile Lys Glu Phe Arg 
225                 230                 235                 240 


Ala Thr Leu Glu Cys His Pro Leu Thr Met Thr Asp Pro Ile Glu Glu 
                245                 250                 255     


His Arg Ile Cys Val Cys Val Arg Lys Arg Pro Leu Asn Lys Gln Glu 
            260                 265                 270         


Leu Ala Lys Lys Glu Ile Asp Val Ile Ser Ile Pro Ser Lys Cys Leu 
        275                 280                 285             


Leu Leu Val His Glu Pro Lys Leu Lys Val Asp Leu Thr Lys Tyr Leu 
    290                 295                 300                 


Glu Asn Gln Ala Phe Cys Phe Asp Phe Ala Phe Asp Glu Thr Ala Ser 
305                 310                 315                 320 


Asn Glu Val Val Tyr Arg Phe Thr Ala Arg Pro Leu Val Gln Thr Ile 
                325                 330                 335     


Phe Glu Gly Gly Lys Ala Thr Cys Phe Ala Tyr Gly Gln Thr Gly Ser 
            340                 345                 350         


Gly Lys Thr His Thr Met Gly Gly Asp Leu Ser Gly Lys Ala Gln Asn 
        355                 360                 365             


Ala Ser Lys Gly Ile Tyr Ala Met Ala Ser Arg Asp Val Phe Leu Leu 
    370                 375                 380                 


Lys Asn Gln Pro Cys Tyr Arg Lys Leu Gly Leu Glu Val Tyr Val Thr 
385                 390                 395                 400 


Phe Phe Glu Ile Tyr Asn Gly Lys Leu Phe Asp Leu Leu Asn Lys Lys 
                405                 410                 415     


Ala Lys Leu Arg Val Leu Glu Asp Gly Lys Gln Gln Val Gln Val Val 
            420                 425                 430         


Gly Leu Gln Glu His Leu Val Asn Ser Ala Asp Asp Val Ile Lys Met 
        435                 440                 445             


Ile Asp Met Gly Ser Ala Cys Arg Thr Ser Gly Gln Thr Phe Ala Asn 
    450                 455                 460                 


Ser Asn Ser Ser Arg Ser His Ala Cys Phe Gln Ile Ile Leu Arg Ala 
465                 470                 475                 480 


Lys Gly Arg Met His Gly Lys Phe Ser Leu Val Asp Leu Ala Gly Asn 
                485                 490                 495     


Glu Arg Gly Ala Asp Thr Ser Ser Ala Asp Arg Gln Thr Arg Met Glu 
            500                 505                 510         


Gly Ala Glu Ile Asn Lys Ser Leu Leu Ala Leu Lys Glu Cys Ile Arg 
        515                 520                 525             


Ala Leu Gly Gln Asn Lys Ala His Thr Pro Phe Arg Glu Ser Lys Leu 
    530                 535                 540                 


Thr Gln Val Leu Arg Asp Ser Phe Ile Gly Glu Asn Ser Arg Thr Cys 
545                 550                 555                 560 


Met Ile Ala Thr Ile Ser Pro Gly Ile Ser Ser Cys Glu Tyr Thr Leu 
                565                 570                 575     


Asn Thr Leu Arg Tyr Ala Asp Arg Val Lys Glu Leu Ser Pro His Ser 
            580                 585                 590         


Gly Pro Ser Gly Glu Gln Leu Ile Gln Met Glu Thr Glu Glu Met Glu 
        595                 600                 605             


Ala Cys Ser Asn Gly Ala Leu Ile Pro Gly Asn Leu Ser Lys Glu Glu 
    610                 615                 620                 


Glu Glu Leu Ser Ser Gln Met Ser Ser Phe Asn Glu Ala Met Thr Gln 
625                 630                 635                 640 


Ile Arg Glu Leu Glu Glu Lys Ala Met Glu Glu Leu Lys Glu Ile Ile 
                645                 650                 655     


Gln Gln Gly Pro Asp Trp Leu Glu Leu Ser Glu Met Thr Glu Gln Pro 
            660                 665                 670         


Asp Tyr Asp Leu Glu Thr Phe Val Asn Lys Ala Glu Ser Ala Leu Ala 
        675                 680                 685             


Gln Gln Ala Lys His Phe Ser Ala Leu Arg Asp Val Ile Lys Ala Leu 
    690                 695                 700                 


Arg Leu Ala Met Gln Leu Glu Glu Gln Ala Ser Arg Gln Ile Ser Ser 
705                 710                 715                 720 


Lys Lys Arg Pro Gln 
                725 


<210>  55
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Ser Val Trp Gln Arg Leu Gly Phe Tyr Ala Ser Leu Leu Lys 
1               5                   10                  15      


Arg Gln Leu Asn Gly Gly Pro Asp Val Ile Lys Trp Glu Arg Arg Val 
            20                  25                  30          


Ile Pro Gly Cys Thr Arg Ser Ile Tyr Ser Ala Thr Gly Lys Trp Thr 
        35                  40                  45              


Lys Glu Tyr Thr Leu Gln Thr Arg Lys Asp Val Glu Lys Trp Trp His 
    50                  55                  60                  


Gln Arg Ile Lys Glu Gln Ala Ser Lys Ile Ser Glu Ala Asp Lys Ser 
65                  70                  75                  80  


Lys Pro Lys Phe Tyr Val Leu Ser Met Phe Pro Tyr Pro Ser Gly Lys 
                85                  90                  95      


Leu His Met Gly His Val Arg Val Tyr Thr Ile Ser Asp Thr Ile Ala 
            100                 105                 110         


Arg Phe Gln Lys Met Arg Gly Met Gln Val Ile Asn Pro Met Gly Trp 
        115                 120                 125             


Asp Ala Phe Gly Leu Pro Ala Glu Asn Ala Ala Val Glu Arg Asn Leu 
    130                 135                 140                 


His Pro Gln Ser Trp Thr Gln Ser Asn Ile Lys His Met Arg Lys Gln 
145                 150                 155                 160 


Leu Asp Arg Leu Gly Leu Cys Phe Ser Trp Asp Arg Glu Ile Thr Thr 
                165                 170                 175     


Cys Leu Pro Asp Tyr Tyr Lys Trp Thr Gln Tyr Leu Phe Ile Lys Leu 
            180                 185                 190         


Tyr Glu Ala Gly Leu Ala Tyr Gln Lys Glu Ala Leu Val Asn Trp Asp 
        195                 200                 205             


Pro Val Asp Gln Thr Val Leu Ala Asn Glu Gln Val Asp Glu His Gly 
    210                 215                 220                 


Cys Ser Trp Arg Ser Gly Ala Lys Val Glu Gln Lys Tyr Leu Arg Gln 
225                 230                 235                 240 


Trp Phe Ile Lys Thr Thr Ala Tyr Ala Lys Ala Met Gln Asp Ala Leu 
                245                 250                 255     


Ala Asp Leu Pro Glu Trp Tyr Gly Ile Lys Gly Met Gln Ala His Trp 
            260                 265                 270         


Ile Gly Asp Cys Val Gly Cys His Leu Asp Phe Thr Leu Lys Val His 
        275                 280                 285             


Gly Gln Ala Thr Gly Glu Lys Leu Thr Ala Tyr Thr Ala Thr Pro Glu 
    290                 295                 300                 


Ala Ile Tyr Gly Thr Ser His Val Ala Ile Ser Pro Ser His Arg Leu 
305                 310                 315                 320 


Leu His Gly His Ser Ser Leu Lys Glu Ala Leu Arg Met Ala Leu Val 
                325                 330                 335     


Pro Gly Lys Asp Cys Leu Thr Pro Val Met Ala Val Asn Met Leu Thr 
            340                 345                 350         


Gln Gln Glu Val Pro Val Val Ile Leu Ala Lys Ala Asp Leu Glu Gly 
        355                 360                 365             


Ser Leu Asp Ser Lys Ile Gly Ile Pro Ser Thr Ser Ser Glu Asp Thr 
    370                 375                 380                 


Ile Leu Ala Gln Thr Leu Gly Leu Ala Tyr Ser Glu Val Ile Glu Thr 
385                 390                 395                 400 


Leu Pro Asp Gly Thr Glu Arg Leu Ser Ser Ser Ala Glu Phe Thr Gly 
                405                 410                 415     


Met Thr Arg Gln Asp Ala Phe Leu Ala Leu Thr Gln Lys Ala Arg Gly 
            420                 425                 430         


Lys Arg Val Gly Gly Asp Val Thr Ser Asp Lys Leu Lys Asp Trp Leu 
        435                 440                 445             


Ile Ser Arg Gln Arg Tyr Trp Gly Thr Pro Ile Pro Ile Val His Cys 
    450                 455                 460                 


Pro Val Cys Gly Pro Thr Pro Val Pro Leu Glu Asp Leu Pro Val Thr 
465                 470                 475                 480 


Leu Pro Asn Ile Ala Ser Phe Thr Gly Lys Gly Gly Pro Pro Leu Ala 
                485                 490                 495     


Met Ala Ser Glu Trp Val Asn Cys Ser Cys Pro Arg Cys Lys Gly Ala 
            500                 505                 510         


Ala Lys Arg Glu Thr Asp Thr Met Asp Thr Phe Val Asp Ser Ala Trp 
        515                 520                 525             


Tyr Tyr Phe Arg Tyr Thr Asp Pro His Asn Pro His Ser Pro Phe Asn 
    530                 535                 540                 


Thr Ala Val Ala Asp Tyr Trp Met Pro Val Asp Leu Tyr Ile Gly Gly 
545                 550                 555                 560 


Lys Glu His Ala Val Met His Leu Phe Tyr Ala Arg Phe Phe Ser His 
                565                 570                 575     


Phe Cys His Asp Gln Lys Met Val Lys His Arg Glu Pro Phe His Lys 
            580                 585                 590         


Leu Leu Ala Gln Gly Leu Ile Lys Gly Gln Thr Phe Arg Leu Pro Ser 
        595                 600                 605             


Gly Gln Tyr Leu Gln Arg Glu Glu Val Asp Leu Thr Gly Ser Val Pro 
    610                 615                 620                 


Val His Ala Lys Thr Lys Glu Lys Leu Glu Val Thr Trp Glu Lys Met 
625                 630                 635                 640 


Ser Lys Ser Lys His Asn Gly Val Asp Pro Glu Glu Val Val Glu Gln 
                645                 650                 655     


Tyr Gly Ile Asp Thr Ile Arg Leu Tyr Ile Leu Phe Ala Ala Pro Pro 
            660                 665                 670         


Glu Lys Asp Ile Leu Trp Asp Val Lys Thr Asp Ala Leu Pro Gly Val 
        675                 680                 685             


Leu Arg Trp Gln Gln Arg Leu Trp Thr Leu Thr Thr Arg Phe Ile Glu 
    690                 695                 700                 


Ala Arg Ala Ser Gly Lys Ser Pro Gln Pro Gln Leu Leu Ser Asn Lys 
705                 710                 715                 720 


Glu Lys Ala Glu Ala Arg Lys Leu Trp Glu Tyr Lys Asn Ser Val Ile 
                725                 730                 735     


Ser Gln Val Thr Thr His Phe Thr Glu Asp Phe Ser Leu Asn Ser Ala 
            740                 745                 750         


Ile Ser Gln Leu Met Gly Leu Ser Asn Ala Leu Ser Gln Ala Ser Gln 
        755                 760                 765             


Ser Val Ile Leu His Ser Pro Glu Phe Glu Asp Ala Leu Cys Ala Leu 
    770                 775                 780                 


Met Val Met Ala Ala Pro Leu Ala Pro His Val Thr Ser Glu Ile Trp 
785                 790                 795                 800 


Ala Gly Leu Ala Leu Val Pro Arg Lys Leu Cys Ala His Tyr Thr Trp 
                805                 810                 815     


Asp Ala Ser Val Leu Leu Gln Ala Trp Pro Ala Val Asp Pro Glu Phe 
            820                 825                 830         


Leu Gln Gln Pro Glu Val Val Gln Met Ala Val Leu Ile Asn Asn Lys 
        835                 840                 845             


Ala Cys Gly Lys Ile Pro Val Pro Gln Gln Val Ala Arg Asp Gln Asp 
    850                 855                 860                 


Lys Val His Glu Phe Val Leu Gln Ser Glu Leu Gly Val Arg Leu Leu 
865                 870                 875                 880 


Gln Gly Arg Ser Ile Lys Lys Ser Phe Leu Ser Pro Arg Thr Ala Leu 
                885                 890                 895     


Ile Asn Phe Leu Val Gln Asp 
            900             


<210>  56
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  57
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ala Val Glu Thr Arg Val Cys Glu Thr Asp Gly Cys Ser Ser 
1               5                   10                  15      


Glu Ala Lys Leu Gln Cys Pro Thr Cys Ile Lys Leu Gly Ile Gln Gly 
            20                  25                  30          


Ser Tyr Phe Cys Ser Gln Glu Cys Phe Lys Gly Ser Trp Ala Thr His 
        35                  40                  45              


Lys Leu Leu His Lys Lys Ala Lys Asp Glu Lys Ala Lys Arg Glu Val 
    50                  55                  60                  


Ser Ser Trp Thr Val Glu Gly Asp Ile Asn Thr Asp Pro Trp Ala Gly 
65                  70                  75                  80  


Tyr Arg Tyr Thr Gly Lys Leu Arg Pro His Tyr Pro Leu Met Pro Thr 
                85                  90                  95      


Arg Pro Val Pro Ser Tyr Ile Gln Arg Pro Asp Tyr Ala Asp His Pro 
            100                 105                 110         


Leu Gly Met Ser Glu Ser Glu Gln Ala Leu Lys Gly Thr Ser Gln Ile 
        115                 120                 125             


Lys Leu Leu Ser Ser Glu Asp Ile Glu Gly Met Arg Leu Val Cys Arg 
    130                 135                 140                 


Leu Ala Arg Glu Val Leu Asp Val Ala Ala Gly Met Ile Lys Pro Gly 
145                 150                 155                 160 


Val Thr Thr Glu Glu Ile Asp His Ala Val His Leu Ala Cys Ile Ala 
                165                 170                 175     


Arg Asn Cys Tyr Pro Ser Pro Leu Asn Tyr Tyr Asn Phe Pro Lys Ser 
            180                 185                 190         


Cys Cys Thr Ser Val Asn Glu Val Ile Cys His Gly Ile Pro Asp Arg 
        195                 200                 205             


Arg Pro Leu Gln Glu Gly Asp Ile Val Asn Val Asp Ile Thr Leu Tyr 
    210                 215                 220                 


Arg Asn Gly Tyr His Gly Asp Leu Asn Glu Thr Phe Phe Val Gly Glu 
225                 230                 235                 240 


Val Asp Asp Gly Ala Arg Lys Leu Val Gln Thr Thr Tyr Glu Cys Leu 
                245                 250                 255     


Met Gln Ala Ile Asp Ala Val Lys Pro Gly Val Arg Tyr Arg Glu Leu 
            260                 265                 270         


Gly Asn Ile Ile Gln Lys His Ala Gln Ala Asn Gly Phe Ser Val Val 
        275                 280                 285             


Arg Ser Tyr Cys Gly His Gly Ile His Lys Leu Phe His Thr Ala Pro 
    290                 295                 300                 


Asn Val Pro His Tyr Ala Lys Asn Lys Ala Val Gly Val Met Lys Ser 
305                 310                 315                 320 


Gly His Val Phe Thr Ile Glu Pro Met Ile Cys Glu Gly Gly Trp Gln 
                325                 330                 335     


Asp Glu Thr Trp Pro Asp Gly Trp Thr Ala Val Thr Arg Asp Gly Lys 
            340                 345                 350         


Arg Ser Ala Gln Phe Glu His Thr Leu Leu Val Thr Asp Thr Gly Cys 
        355                 360                 365             


Glu Ile Leu Thr Arg Arg Leu Asp Ser Ala Arg Pro His Phe Met Ser 
    370                 375                 380                 


Gln Phe 
385     


<210>  58
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Val Ala Arg Val Gly Leu Leu Leu Arg Ala Leu Gln Leu Leu Leu 
1               5                   10                  15      


Trp Gly His Leu Asp Ala Gln Pro Ala Glu Arg Gly Gly Gln Glu Leu 
            20                  25                  30          


Arg Lys Glu Ala Glu Ala Phe Leu Glu Lys Tyr Gly Tyr Leu Asn Glu 
        35                  40                  45              


Gln Val Pro Lys Ala Pro Thr Ser Thr Arg Phe Ser Asp Ala Ile Arg 
    50                  55                  60                  


Ala Phe Gln Trp Val Ser Gln Leu Pro Val Ser Gly Val Leu Asp Arg 
65                  70                  75                  80  


Ala Thr Leu Arg Gln Met Thr Arg Pro Arg Cys Gly Val Thr Asp Thr 
                85                  90                  95      


Asn Ser Tyr Ala Ala Trp Ala Glu Arg Ile Ser Asp Leu Phe Ala Arg 
            100                 105                 110         


His Arg Thr Lys Met Arg Arg Lys Lys Arg Phe Ala Lys Gln Gly Asn 
        115                 120                 125             


Lys Trp Tyr Lys Gln His Leu Ser Tyr Arg Leu Val Asn Trp Pro Glu 
    130                 135                 140                 


His Leu Pro Glu Pro Ala Val Arg Gly Ala Val Arg Ala Ala Phe Gln 
145                 150                 155                 160 


Leu Trp Ser Asn Val Ser Ala Leu Glu Phe Trp Glu Ala Pro Ala Thr 
                165                 170                 175     


Gly Pro Ala Asp Ile Arg Leu Thr Phe Phe Gln Gly Asp His Asn Asp 
            180                 185                 190         


Gly Leu Gly Asn Ala Phe Asp Gly Pro Gly Gly Ala Leu Ala His Ala 
        195                 200                 205             


Phe Leu Pro Arg Arg Gly Glu Ala His Phe Asp Gln Asp Glu Arg Trp 
    210                 215                 220                 


Ser Leu Ser Arg Arg Arg Gly Arg Asn Leu Phe Val Val Leu Ala His 
225                 230                 235                 240 


Glu Ile Gly His Thr Leu Gly Leu Thr His Ser Pro Ala Pro Arg Ala 
                245                 250                 255     


Leu Met Ala Pro Tyr Tyr Lys Arg Leu Gly Arg Asp Ala Leu Leu Ser 
            260                 265                 270         


Trp Asp Asp Val Leu Ala Val Gln Ser Leu Tyr Gly Lys Pro Leu Gly 
        275                 280                 285             


Gly Ser Val Ala Val Gln Leu Pro Gly Lys Leu Phe Thr Asp Phe Glu 
    290                 295                 300                 


Thr Trp Asp Ser Tyr Ser Pro Gln Gly Arg Arg Pro Glu Thr Gln Gly 
305                 310                 315                 320 


Pro Lys Tyr Cys His Ser Ser Phe Asp Ala Ile Thr Val Asp Arg Gln 
                325                 330                 335     


Gln Gln Leu Tyr Ile Phe Lys Gly Ser His Phe Trp Glu Val Ala Ala 
            340                 345                 350         


Asp Gly Asn Val Ser Glu Pro Arg Pro Leu Gln Glu Arg Trp Val Gly 
        355                 360                 365             


Leu Pro Pro Asn Ile Glu Ala Ala Ala Val Ser Leu Asn Asp Gly Asp 
    370                 375                 380                 


Phe Tyr Phe Phe Lys Gly Gly Arg Cys Trp Arg Phe Arg Gly Pro Lys 
385                 390                 395                 400 


Pro Val Trp Gly Leu Pro Gln Leu Cys Arg Ala Gly Gly Leu Pro Arg 
                405                 410                 415     


His Pro Asp Ala Ala Leu Phe Phe Pro Pro Leu Arg Arg Leu Ile Leu 
            420                 425                 430         


Phe Lys Gly Ala Arg Tyr Tyr Val Leu Ala Arg Gly Gly Leu Gln Val 
        435                 440                 445             


Glu Pro Tyr Tyr Pro Arg Ser Leu Gln Asp Trp Gly Gly Ile Pro Glu 
    450                 455                 460                 


Glu Val Ser Gly Ala Leu Pro Arg Pro Asp Gly Ser Ile Ile Phe Phe 
465                 470                 475                 480 


Arg Asp Asp Arg Tyr Trp Arg Leu Asp Gln Ala Lys Leu Gln Ala Thr 
                485                 490                 495     


Thr Ser Gly Arg Trp Ala Thr Glu Leu Pro Trp Met Gly Cys Trp His 
            500                 505                 510         


Ala Asn Ser Gly Ser Ala Leu Phe 
        515                 520 


<210>  59
<211>  2549
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Leu Gly Thr Gly Pro Ala Ala Ala Thr Thr Ala Ala Thr Thr Ser 
1               5                   10                  15      


Ser Asn Val Ser Val Leu Gln Gln Phe Ala Ser Gly Leu Lys Ser Arg 
            20                  25                  30          


Asn Glu Glu Thr Arg Ala Lys Ala Ala Lys Glu Leu Gln His Tyr Val 
        35                  40                  45              


Thr Met Glu Leu Arg Glu Met Ser Gln Glu Glu Ser Thr Arg Phe Tyr 
    50                  55                  60                  


Asp Gln Leu Asn His His Ile Phe Glu Leu Val Ser Ser Ser Asp Ala 
65                  70                  75                  80  


Asn Glu Arg Lys Gly Gly Ile Leu Ala Ile Ala Ser Leu Ile Gly Val 
                85                  90                  95      


Glu Gly Gly Asn Ala Thr Arg Ile Gly Arg Phe Ala Asn Tyr Leu Arg 
            100                 105                 110         


Asn Leu Leu Pro Ser Asn Asp Pro Val Val Met Glu Met Ala Ser Lys 
        115                 120                 125             


Ala Ile Gly Arg Leu Ala Met Ala Gly Asp Thr Phe Thr Ala Glu Tyr 
    130                 135                 140                 


Val Glu Phe Glu Val Lys Arg Ala Leu Glu Trp Leu Gly Ala Asp Arg 
145                 150                 155                 160 


Asn Glu Gly Arg Arg His Ala Ala Val Leu Val Leu Arg Glu Leu Ala 
                165                 170                 175     


Ile Ser Val Pro Thr Phe Phe Phe Gln Gln Val Gln Pro Phe Phe Asp 
            180                 185                 190         


Asn Ile Phe Val Ala Val Trp Asp Pro Lys Gln Ala Ile Arg Glu Gly 
        195                 200                 205             


Ala Val Ala Ala Leu Arg Ala Cys Leu Ile Leu Thr Thr Gln Arg Glu 
    210                 215                 220                 


Pro Lys Glu Met Gln Lys Pro Gln Trp Tyr Arg His Thr Phe Glu Glu 
225                 230                 235                 240 


Ala Glu Lys Gly Phe Asp Glu Thr Leu Ala Lys Glu Lys Gly Met Asn 
                245                 250                 255     


Arg Asp Asp Arg Ile His Gly Ala Leu Leu Ile Leu Asn Glu Leu Val 
            260                 265                 270         


Arg Ile Ser Ser Met Glu Gly Glu Arg Leu Arg Glu Glu Met Glu Glu 
        275                 280                 285             


Ile Thr Gln Gln Gln Leu Val His Asp Lys Tyr Cys Lys Asp Leu Met 
    290                 295                 300                 


Gly Phe Gly Thr Lys Pro Arg His Ile Thr Pro Phe Thr Ser Phe Gln 
305                 310                 315                 320 


Ala Val Gln Pro Gln Gln Ser Asn Ala Leu Val Gly Leu Leu Gly Tyr 
                325                 330                 335     


Ser Ser His Gln Gly Leu Met Gly Phe Gly Thr Ser Pro Ser Pro Ala 
            340                 345                 350         


Lys Ser Thr Leu Val Glu Ser Arg Cys Cys Arg Asp Leu Met Glu Glu 
        355                 360                 365             


Lys Phe Asp Gln Val Cys Gln Trp Val Leu Lys Cys Arg Asn Ser Lys 
    370                 375                 380                 


Asn Ser Leu Ile Gln Met Thr Ile Leu Asn Leu Leu Pro Arg Leu Ala 
385                 390                 395                 400 


Ala Phe Arg Pro Ser Ala Phe Thr Asp Thr Gln Tyr Leu Gln Asp Thr 
                405                 410                 415     


Met Asn His Val Leu Ser Cys Val Lys Lys Glu Lys Glu Arg Thr Ala 
            420                 425                 430         


Ala Phe Gln Ala Leu Gly Leu Leu Ser Val Ala Val Arg Ser Glu Phe 
        435                 440                 445             


Lys Val Tyr Leu Pro Arg Val Leu Asp Ile Ile Arg Ala Ala Leu Pro 
    450                 455                 460                 


Pro Lys Asp Phe Ala His Lys Arg Gln Lys Ala Met Gln Val Asp Ala 
465                 470                 475                 480 


Thr Val Phe Thr Cys Ile Ser Met Leu Ala Arg Ala Met Gly Pro Gly 
                485                 490                 495     


Ile Gln Gln Asp Ile Lys Glu Leu Leu Glu Pro Met Leu Ala Val Gly 
            500                 505                 510         


Leu Ser Pro Ala Leu Thr Ala Val Leu Tyr Asp Leu Ser Arg Gln Ile 
        515                 520                 525             


Pro Gln Leu Lys Lys Asp Ile Gln Asp Gly Leu Leu Lys Met Leu Ser 
    530                 535                 540                 


Leu Val Leu Met His Lys Pro Leu Arg His Pro Gly Met Pro Lys Gly 
545                 550                 555                 560 


Leu Ala His Gln Leu Ala Ser Pro Gly Leu Thr Thr Leu Pro Glu Ala 
                565                 570                 575     


Ser Asp Val Gly Ser Ile Thr Leu Ala Leu Arg Thr Leu Gly Ser Phe 
            580                 585                 590         


Glu Phe Glu Gly His Ser Leu Thr Gln Phe Val Arg His Cys Ala Asp 
        595                 600                 605             


His Phe Leu Asn Ser Glu His Lys Glu Ile Arg Met Glu Ala Ala Arg 
    610                 615                 620                 


Thr Cys Ser Arg Leu Leu Thr Pro Ser Ile His Leu Ile Ser Gly His 
625                 630                 635                 640 


Ala His Val Val Ser Gln Thr Ala Val Gln Val Val Ala Asp Val Leu 
                645                 650                 655     


Ser Lys Leu Leu Val Val Gly Ile Thr Asp Pro Asp Pro Asp Ile Arg 
            660                 665                 670         


Tyr Cys Val Leu Ala Ser Leu Asp Glu Arg Phe Asp Ala His Leu Ala 
        675                 680                 685             


Gln Ala Glu Asn Leu Gln Ala Leu Phe Val Ala Leu Asn Asp Gln Val 
    690                 695                 700                 


Phe Glu Ile Arg Glu Leu Ala Ile Cys Thr Val Gly Arg Leu Ser Ser 
705                 710                 715                 720 


Met Asn Pro Ala Phe Val Met Pro Phe Leu Arg Lys Met Leu Ile Gln 
                725                 730                 735     


Ile Leu Thr Glu Leu Glu His Ser Gly Ile Gly Arg Ile Lys Glu Gln 
            740                 745                 750         


Ser Ala Arg Met Leu Gly His Leu Val Ser Asn Ala Pro Arg Leu Ile 
        755                 760                 765             


Arg Pro Tyr Met Glu Pro Ile Leu Lys Ala Leu Ile Leu Lys Leu Lys 
    770                 775                 780                 


Asp Pro Asp Pro Asp Pro Asn Pro Gly Val Ile Asn Asn Val Leu Ala 
785                 790                 795                 800 


Thr Ile Gly Glu Leu Ala Gln Val Ser Gly Leu Glu Met Arg Lys Trp 
                805                 810                 815     


Val Asp Glu Leu Phe Ile Ile Ile Met Asp Met Leu Gln Asp Ser Ser 
            820                 825                 830         


Leu Leu Ala Lys Arg Gln Val Ala Leu Trp Thr Leu Gly Gln Leu Val 
        835                 840                 845             


Ala Ser Thr Gly Tyr Val Val Glu Pro Tyr Arg Lys Tyr Pro Thr Leu 
    850                 855                 860                 


Leu Glu Val Leu Leu Asn Phe Leu Lys Thr Glu Gln Asn Gln Gly Thr 
865                 870                 875                 880 


Arg Arg Glu Ala Ile Arg Val Leu Gly Leu Leu Gly Ala Leu Asp Pro 
                885                 890                 895     


Tyr Lys His Lys Val Asn Ile Gly Met Ile Asp Gln Ser Arg Asp Ala 
            900                 905                 910         


Ser Ala Val Ser Leu Ser Glu Ser Lys Ser Ser Gln Asp Ser Ser Asp 
        915                 920                 925             


Tyr Ser Thr Ser Glu Met Leu Val Asn Met Gly Asn Leu Pro Leu Asp 
    930                 935                 940                 


Glu Phe Tyr Pro Ala Val Ser Met Val Ala Leu Met Arg Ile Phe Arg 
945                 950                 955                 960 


Asp Gln Ser Leu Ser His His His Thr Met Val Val Gln Ala Ile Thr 
                965                 970                 975     


Phe Ile Phe Lys Ser Leu Gly Leu Lys Cys Val Gln Phe Leu Pro Gln 
            980                 985                 990         


Val Met Pro Thr Phe Leu Asn Val  Ile Arg Val Cys Asp  Gly Ala Ile 
        995                 1000                 1005             


Arg Glu  Phe Leu Phe Gln Gln  Leu Gly Met Leu Val  Ser Phe Val 
    1010                 1015                 1020             


Lys Ser  His Ile Arg Pro Tyr  Met Asp Glu Ile Val  Thr Leu Met 
    1025                 1030                 1035             


Arg Glu  Phe Trp Val Met Asn  Thr Ser Ile Gln Ser  Thr Ile Ile 
    1040                 1045                 1050             


Leu Leu  Ile Glu Gln Ile Val  Val Ala Leu Gly Gly  Glu Phe Lys 
    1055                 1060                 1065             


Leu Tyr  Leu Pro Gln Leu Ile  Pro His Met Leu Arg  Val Phe Met 
    1070                 1075                 1080             


His Asp  Asn Ser Pro Gly Arg  Ile Val Ser Ile Lys  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ile  Gln Leu Phe Gly Ala  Asn Leu Asp Asp Tyr  Leu His Leu 
    1100                 1105                 1110             


Leu Leu  Pro Pro Ile Val Lys  Leu Phe Asp Ala Pro  Glu Ala Pro 
    1115                 1120                 1125             


Leu Pro  Ser Arg Lys Ala Ala  Leu Glu Thr Val Asp  Arg Leu Thr 
    1130                 1135                 1140             


Glu Ser  Leu Asp Phe Thr Asp  Tyr Ala Ser Arg Ile  Ile His Pro 
    1145                 1150                 1155             


Ile Val  Arg Thr Leu Asp Gln  Ser Pro Glu Leu Arg  Ser Thr Ala 
    1160                 1165                 1170             


Met Asp  Thr Leu Ser Ser Leu  Val Phe Gln Leu Gly  Lys Lys Tyr 
    1175                 1180                 1185             


Gln Ile  Phe Ile Pro Met Val  Asn Lys Val Leu Val  Arg His Arg 
    1190                 1195                 1200             


Ile Asn  His Gln Arg Tyr Asp  Val Leu Ile Cys Arg  Ile Val Lys 
    1205                 1210                 1215             


Gly Tyr  Thr Leu Ala Asp Glu  Glu Glu Asp Pro Leu  Ile Tyr Gln 
    1220                 1225                 1230             


His Arg  Met Leu Arg Ser Gly  Gln Gly Asp Ala Leu  Ala Ser Gly 
    1235                 1240                 1245             


Pro Val  Glu Thr Gly Pro Met  Lys Lys Leu His Val  Ser Thr Ile 
    1250                 1255                 1260             


Asn Leu  Gln Lys Ala Trp Gly  Ala Ala Arg Arg Val  Ser Lys Asp 
    1265                 1270                 1275             


Asp Trp  Leu Glu Trp Leu Arg  Arg Leu Ser Leu Glu  Leu Leu Lys 
    1280                 1285                 1290             


Asp Ser  Ser Ser Pro Ser Leu  Arg Ser Cys Trp Ala  Leu Ala Gln 
    1295                 1300                 1305             


Ala Tyr  Asn Pro Met Ala Arg  Asp Leu Phe Asn Ala  Ala Phe Val 
    1310                 1315                 1320             


Ser Cys  Trp Ser Glu Leu Asn  Glu Asp Gln Gln Asp  Glu Leu Ile 
    1325                 1330                 1335             


Arg Ser  Ile Glu Leu Ala Leu  Thr Ser Gln Asp Ile  Ala Glu Val 
    1340                 1345                 1350             


Thr Gln  Thr Leu Leu Asn Leu  Ala Glu Phe Met Glu  His Ser Asp 
    1355                 1360                 1365             


Lys Gly  Pro Leu Pro Leu Arg  Asp Asp Asn Gly Ile  Val Leu Leu 
    1370                 1375                 1380             


Gly Glu  Arg Ala Ala Lys Cys  Arg Ala Tyr Ala Lys  Ala Leu His 
    1385                 1390                 1395             


Tyr Lys  Glu Leu Glu Phe Gln  Lys Gly Pro Thr Pro  Ala Ile Leu 
    1400                 1405                 1410             


Glu Ser  Leu Ile Ser Ile Asn  Asn Lys Leu Gln Gln  Pro Glu Ala 
    1415                 1420                 1425             


Ala Ala  Gly Val Leu Glu Tyr  Ala Met Lys His Phe  Gly Glu Leu 
    1430                 1435                 1440             


Glu Ile  Gln Ala Thr Trp Tyr  Glu Lys Leu His Glu  Trp Glu Asp 
    1445                 1450                 1455             


Ala Leu  Val Ala Tyr Asp Lys  Lys Met Asp Thr Asn  Lys Asp Asp 
    1460                 1465                 1470             


Pro Glu  Leu Met Leu Gly Arg  Met Arg Cys Leu Glu  Ala Leu Gly 
    1475                 1480                 1485             


Glu Trp  Gly Gln Leu His Gln  Gln Cys Cys Glu Lys  Trp Thr Leu 
    1490                 1495                 1500             


Val Asn  Asp Glu Thr Gln Ala  Lys Met Ala Arg Met  Ala Ala Ala 
    1505                 1510                 1515             


Ala Ala  Trp Gly Leu Gly Gln  Trp Asp Ser Met Glu  Glu Tyr Thr 
    1520                 1525                 1530             


Cys Met  Ile Pro Arg Asp Thr  His Asp Gly Ala Phe  Tyr Arg Ala 
    1535                 1540                 1545             


Val Leu  Ala Leu His Gln Asp  Leu Phe Ser Leu Ala  Gln Gln Cys 
    1550                 1555                 1560             


Ile Asp  Lys Ala Arg Asp Leu  Leu Asp Ala Glu Leu  Thr Ala Met 
    1565                 1570                 1575             


Ala Gly  Glu Ser Tyr Ser Arg  Ala Tyr Gly Ala Met  Val Ser Cys 
    1580                 1585                 1590             


His Met  Leu Ser Glu Leu Glu  Glu Val Ile Gln Tyr  Lys Leu Val 
    1595                 1600                 1605             


Pro Glu  Arg Arg Glu Ile Ile  Arg Gln Ile Trp Trp  Glu Arg Leu 
    1610                 1615                 1620             


Gln Gly  Cys Gln Arg Ile Val  Glu Asp Trp Gln Lys  Ile Leu Met 
    1625                 1630                 1635             


Val Arg  Ser Leu Val Val Ser  Pro His Glu Asp Met  Arg Thr Trp 
    1640                 1645                 1650             


Leu Lys  Tyr Ala Ser Leu Cys  Gly Lys Ser Gly Arg  Leu Ala Leu 
    1655                 1660                 1665             


Ala His  Lys Thr Leu Val Leu  Leu Leu Gly Val Asp  Pro Ser Arg 
    1670                 1675                 1680             


Gln Leu  Asp His Pro Leu Pro  Thr Val His Pro Gln  Val Thr Tyr 
    1685                 1690                 1695             


Ala Tyr  Met Lys Asn Met Trp  Lys Ser Ala Arg Lys  Ile Asp Ala 
    1700                 1705                 1710             


Phe Gln  His Met Gln His Phe  Val Gln Thr Met Gln  Gln Gln Ala 
    1715                 1720                 1725             


Gln His  Ala Ile Ala Thr Glu  Asp Gln Gln His Lys  Gln Glu Leu 
    1730                 1735                 1740             


His Lys  Leu Met Ala Arg Cys  Phe Leu Lys Leu Gly  Glu Trp Gln 
    1745                 1750                 1755             


Leu Asn  Leu Gln Gly Ile Asn  Glu Ser Thr Ile Pro  Lys Val Leu 
    1760                 1765                 1770             


Gln Tyr  Tyr Ser Ala Ala Thr  Glu His Asp Arg Ser  Trp Tyr Lys 
    1775                 1780                 1785             


Ala Trp  His Ala Trp Ala Val  Met Asn Phe Glu Ala  Val Leu His 
    1790                 1795                 1800             


Tyr Lys  His Gln Asn Gln Ala  Arg Asp Glu Lys Lys  Lys Leu Arg 
    1805                 1810                 1815             


His Ala  Ser Gly Ala Asn Ile  Thr Asn Ala Thr Thr  Ala Ala Thr 
    1820                 1825                 1830             


Thr Ala  Ala Thr Ala Thr Thr  Thr Ala Ser Thr Glu  Gly Ser Asn 
    1835                 1840                 1845             


Ser Glu  Ser Glu Ala Glu Ser  Thr Glu Asn Ser Pro  Thr Pro Ser 
    1850                 1855                 1860             


Pro Leu  Gln Lys Lys Val Thr  Glu Asp Leu Ser Lys  Thr Leu Leu 
    1865                 1870                 1875             


Met Tyr  Thr Val Pro Ala Val  Gln Gly Phe Phe Arg  Ser Ile Ser 
    1880                 1885                 1890             


Leu Ser  Arg Gly Asn Asn Leu  Gln Asp Thr Leu Arg  Val Leu Thr 
    1895                 1900                 1905             


Leu Trp  Phe Asp Tyr Gly His  Trp Pro Asp Val Asn  Glu Ala Leu 
    1910                 1915                 1920             


Val Glu  Gly Val Lys Ala Ile  Gln Ile Asp Thr Trp  Leu Gln Val 
    1925                 1930                 1935             


Ile Pro  Gln Leu Ile Ala Arg  Ile Asp Thr Pro Arg  Pro Leu Val 
    1940                 1945                 1950             


Gly Arg  Leu Ile His Gln Leu  Leu Thr Asp Ile Gly  Arg Tyr His 
    1955                 1960                 1965             


Pro Gln  Ala Leu Ile Tyr Pro  Leu Thr Val Ala Ser  Lys Ser Thr 
    1970                 1975                 1980             


Thr Thr  Ala Arg His Asn Ala  Ala Asn Lys Ile Leu  Lys Asn Met 
    1985                 1990                 1995             


Cys Glu  His Ser Asn Thr Leu  Val Gln Gln Ala Met  Met Val Ser 
    2000                 2005                 2010             


Glu Glu  Leu Ile Arg Val Ala  Ile Leu Trp His Glu  Met Trp His 
    2015                 2020                 2025             


Glu Gly  Leu Glu Glu Ala Ser  Arg Leu Tyr Phe Gly  Glu Arg Asn 
    2030                 2035                 2040             


Val Lys  Gly Met Phe Glu Val  Leu Glu Pro Leu His  Ala Met Met 
    2045                 2050                 2055             


Glu Arg  Gly Pro Gln Thr Leu  Lys Glu Thr Ser Phe  Asn Gln Ala 
    2060                 2065                 2070             


Tyr Gly  Arg Asp Leu Met Glu  Ala Gln Glu Trp Cys  Arg Lys Tyr 
    2075                 2080                 2085             


Met Lys  Ser Gly Asn Val Lys  Asp Leu Thr Gln Ala  Trp Asp Leu 
    2090                 2095                 2100             


Tyr Tyr  His Val Phe Arg Arg  Ile Ser Lys Gln Leu  Pro Gln Leu 
    2105                 2110                 2115             


Thr Ser  Leu Glu Leu Gln Tyr  Val Ser Pro Lys Leu  Leu Met Cys 
    2120                 2125                 2130             


Arg Asp  Leu Glu Leu Ala Val  Pro Gly Thr Tyr Asp  Pro Asn Gln 
    2135                 2140                 2145             


Pro Ile  Ile Arg Ile Gln Ser  Ile Ala Pro Ser Leu  Gln Val Ile 
    2150                 2155                 2160             


Thr Ser  Lys Gln Arg Pro Arg  Lys Leu Thr Leu Met  Gly Ser Asn 
    2165                 2170                 2175             


Gly His  Glu Phe Val Phe Leu  Leu Lys Gly His Glu  Asp Leu Arg 
    2180                 2185                 2190             


Gln Asp  Glu Arg Val Met Gln  Leu Phe Gly Leu Val  Asn Thr Leu 
    2195                 2200                 2205             


Leu Ala  Asn Asp Pro Thr Ser  Leu Arg Lys Asn Leu  Ser Ile Gln 
    2210                 2215                 2220             


Arg Tyr  Ala Val Ile Pro Leu  Ser Thr Asn Ser Gly  Leu Ile Gly 
    2225                 2230                 2235             


Trp Val  Pro His Cys Asp Thr  Leu His Ala Leu Ile  Arg Asp Tyr 
    2240                 2245                 2250             


Arg Glu  Lys Lys Lys Ile Leu  Leu Asn Ile Glu His  Arg Ile Met 
    2255                 2260                 2265             


Leu Arg  Met Ala Pro Asp Tyr  Asp His Leu Thr Leu  Met Gln Lys 
    2270                 2275                 2280             


Val Glu  Val Phe Glu His Ala  Val Asn Asn Thr Ala  Gly Asp Asp 
    2285                 2290                 2295             


Leu Ala  Lys Leu Leu Trp Leu  Lys Ser Pro Ser Ser  Glu Val Trp 
    2300                 2305                 2310             


Phe Asp  Arg Arg Thr Asn Tyr  Thr Arg Ser Leu Ala  Val Met Ser 
    2315                 2320                 2325             


Met Val  Gly Tyr Ile Leu Gly  Leu Gly Asp Arg His  Pro Ser Asn 
    2330                 2335                 2340             


Leu Met  Leu Asp Arg Leu Ser  Gly Lys Ile Leu His  Ile Asp Phe 
    2345                 2350                 2355             


Gly Asp  Cys Phe Glu Val Ala  Met Thr Arg Glu Lys  Phe Pro Glu 
    2360                 2365                 2370             


Lys Ile  Pro Phe Arg Leu Thr  Arg Met Leu Thr Asn  Ala Met Glu 
    2375                 2380                 2385             


Val Thr  Gly Leu Asp Gly Asn  Tyr Arg Ile Thr Cys  His Thr Val 
    2390                 2395                 2400             


Met Glu  Val Leu Arg Glu His  Lys Asp Ser Val Met  Ala Val Leu 
    2405                 2410                 2415             


Glu Ala  Phe Val Tyr Asp Pro  Leu Leu Asn Trp Arg  Leu Met Asp 
    2420                 2425                 2430             


Thr Asn  Thr Lys Gly Asn Lys  Arg Ser Arg Thr Arg  Thr Asp Ser 
    2435                 2440                 2445             


Tyr Ser  Ala Gly Gln Ser Val  Glu Ile Leu Asp Gly  Val Glu Leu 
    2450                 2455                 2460             


Gly Glu  Pro Ala His Lys Lys  Thr Gly Thr Thr Val  Pro Glu Ser 
    2465                 2470                 2475             


Ile His  Ser Phe Ile Gly Asp  Gly Leu Val Lys Pro  Glu Ala Leu 
    2480                 2485                 2490             


Asn Lys  Lys Ala Ile Gln Ile  Ile Asn Arg Val Arg  Asp Lys Leu 
    2495                 2500                 2505             


Thr Gly  Arg Asp Phe Ser His  Asp Asp Thr Leu Asp  Val Pro Thr 
    2510                 2515                 2520             


Gln Val  Glu Leu Leu Ile Lys  Gln Ala Thr Ser His  Glu Asn Leu 
    2525                 2530                 2535             


Cys Gln  Cys Tyr Ile Gly Trp  Cys Pro Phe Trp 
    2540                 2545                 


<210>  60
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Leu Gly Val Arg Cys Leu Leu Arg Ser Val Arg Phe Cys Ser Ser 
1               5                   10                  15      


Ala Pro Phe Pro Lys His Lys Pro Ser Ala Lys Leu Ser Val Arg Asp 
            20                  25                  30          


Ala Leu Gly Ala Gln Asn Ala Ser Gly Glu Arg Ile Lys Ile Gln Gly 
        35                  40                  45              


Trp Ile Arg Ser Val Arg Ser Gln Lys Glu Val Leu Phe Leu His Val 
    50                  55                  60                  


Asn Asp Gly Ser Ser Leu Glu Ser Leu Gln Val Val Ala Asp Ser Gly 
65                  70                  75                  80  


Leu Asp Ser Arg Glu Leu Asn Phe Gly Ser Ser Val Glu Val Gln Gly 
                85                  90                  95      


Gln Leu Ile Lys Ser Pro Ser Lys Arg Gln Asn Val Glu Leu Lys Ala 
            100                 105                 110         


Glu Lys Ile Lys Val Ile Gly Asn Cys Asp Ala Lys Asp Phe Pro Ile 
        115                 120                 125             


Lys Tyr Lys Glu Arg His Pro Leu Glu Tyr Leu Arg Gln Tyr Pro His 
    130                 135                 140                 


Phe Arg Cys Arg Thr Asn Val Leu Gly Ser Ile Leu Arg Ile Arg Ser 
145                 150                 155                 160 


Glu Ala Thr Ala Ala Ile His Ser Phe Phe Lys Asp Ser Gly Phe Val 
                165                 170                 175     


His Ile His Thr Pro Ile Ile Thr Ser Asn Asp Ser Glu Gly Ala Gly 
            180                 185                 190         


Glu Leu Phe Gln Leu Glu Pro Ser Gly Lys Leu Lys Val Pro Glu Glu 
        195                 200                 205             


Asn Phe Phe Asn Val Pro Ala Phe Leu Thr Val Ser Gly Gln Leu His 
    210                 215                 220                 


Leu Glu Val Met Ser Gly Ala Phe Thr Gln Val Phe Thr Phe Gly Pro 
225                 230                 235                 240 


Thr Phe Arg Ala Glu Asn Ser Gln Ser Arg Arg His Leu Ala Glu Phe 
                245                 250                 255     


Tyr Met Ile Glu Ala Glu Ile Ser Phe Val Asp Ser Leu Gln Asp Leu 
            260                 265                 270         


Met Gln Val Ile Glu Glu Leu Phe Lys Ala Thr Thr Met Met Val Leu 
        275                 280                 285             


Ser Lys Cys Pro Glu Asp Val Glu Leu Cys His Lys Phe Ile Ala Pro 
    290                 295                 300                 


Gly Gln Lys Asp Arg Leu Glu His Met Leu Lys Asn Asn Phe Leu Ile 
305                 310                 315                 320 


Ile Ser Tyr Thr Glu Ala Val Glu Ile Leu Lys Gln Ala Ser Gln Asn 
                325                 330                 335     


Phe Thr Phe Thr Pro Glu Trp Gly Ala Asp Leu Arg Thr Glu His Glu 
            340                 345                 350         


Lys Tyr Leu Val Lys His Cys Gly Asn Ile Pro Val Phe Val Ile Asn 
        355                 360                 365             


Tyr Pro Leu Thr Leu Lys Pro Phe Tyr Met Arg Asp Asn Glu Asp Gly 
    370                 375                 380                 


Pro Gln His Thr Val Ala Ala Val Asp Leu Leu Val Pro Gly Val Gly 
385                 390                 395                 400 


Glu Leu Phe Gly Gly Gly Leu Arg Glu Glu Arg Tyr His Phe Leu Glu 
                405                 410                 415     


Glu Arg Leu Ala Arg Ser Gly Leu Thr Glu Val Tyr Gln Trp Tyr Leu 
            420                 425                 430         


Asp Leu Arg Arg Phe Gly Ser Val Pro His Gly Gly Phe Gly Met Gly 
        435                 440                 445             


Phe Glu Arg Tyr Leu Gln Cys Ile Leu Gly Val Asp Asn Ile Lys Asp 
    450                 455                 460                 


Val Ile Pro Phe Pro Arg Phe Pro His Ser Cys Leu Leu 
465                 470                 475         


<210>  61
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asn Cys Ile Ser Asp Phe Phe Thr Tyr Glu Thr Thr Lys Ser Val 
1               5                   10                  15      


Val Val Lys Ser Trp Thr Ile Gly Ile Ile Asn Arg Val Val Gln Leu 
            20                  25                  30          


Leu Ile Ile Ser Tyr Phe Val Gly Trp Val Phe Leu His Glu Lys Ala 
        35                  40                  45              


Tyr Gln Val Arg Asp Thr Ala Ile Glu Ser Ser Val Val Thr Lys Val 
    50                  55                  60                  


Lys Gly Ser Gly Leu Tyr Ala Asn Arg Val Met Asp Val Ser Asp Tyr 
65                  70                  75                  80  


Val Thr Pro Pro Gln Gly Thr Ser Val Phe Val Ile Ile Thr Lys Met 
                85                  90                  95      


Ile Val Thr Glu Asn Gln Met Gln Gly Phe Cys Pro Glu Ser Glu Glu 
            100                 105                 110         


Lys Tyr Arg Cys Val Ser Asp Ser Gln Cys Gly Pro Glu Arg Leu Pro 
        115                 120                 125             


Gly Gly Gly Ile Leu Thr Gly Arg Cys Val Asn Tyr Ser Ser Val Leu 
    130                 135                 140                 


Arg Thr Cys Glu Ile Gln Gly Trp Cys Pro Thr Glu Val Asp Thr Val 
145                 150                 155                 160 


Glu Thr Pro Ile Met Met Glu Ala Glu Asn Phe Thr Ile Phe Ile Lys 
                165                 170                 175     


Asn Ser Ile Arg Phe Pro Leu Phe Asn Phe Glu Lys Gly Asn Leu Leu 
            180                 185                 190         


Pro Asn Leu Thr Ala Arg Asp Met Lys Thr Cys Arg Phe His Pro Asp 
        195                 200                 205             


Lys Asp Pro Phe Cys Pro Ile Leu Arg Val Gly Asp Val Val Lys Phe 
    210                 215                 220                 


Ala Gly Gln Asp Phe Ala Lys Leu Ala Arg Thr Gly Gly Val Leu Gly 
225                 230                 235                 240 


Ile Lys Ile Gly Trp Val Cys Asp Leu Asp Lys Ala Trp Asp Gln Cys 
                245                 250                 255     


Ile Pro Lys Tyr Ser Phe Thr Arg Leu Asp Ser Val Ser Glu Lys Ser 
            260                 265                 270         


Ser Val Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Lys Met 
        275                 280                 285             


Glu Asn Gly Ser Glu Tyr Arg Thr Leu Leu Lys Ala Phe Gly Ile Arg 
    290                 295                 300                 


Phe Asp Val Leu Val Tyr Gly Asn Ala Gly Lys Phe Asn Ile Ile Pro 
305                 310                 315                 320 


Thr Ile Ile Ser Ser Val Ala Ala Phe Thr Ser Val Gly Val Gly Thr 
                325                 330                 335     


Val Leu Cys Asp Ile Ile Leu Leu Asn Phe Leu Lys Gly Ala Asp Gln 
            340                 345                 350         


Tyr Lys Ala Lys Lys Phe Glu Glu Val Asn Glu Thr Thr Leu Lys Ile 
        355                 360                 365             


Ala Ala Leu Thr Asn Pro Val Tyr Pro Ser Asp Gln Thr Thr Ala Glu 
    370                 375                 380                 


Lys Gln Ser Thr Asp Ser Gly Ala Phe Ser Ile Gly His 
385                 390                 395         


<210>  62
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Ala Val Ser Gly Leu Val Arg Arg Pro Leu Arg Glu Val Ser 
1               5                   10                  15      


Gly Leu Leu Lys Arg Arg Phe His Trp Thr Ala Pro Ala Ala Leu Gln 
            20                  25                  30          


Val Thr Val Arg Asp Ala Ile Asn Gln Gly Met Asp Glu Glu Leu Glu 
        35                  40                  45              


Arg Asp Glu Lys Val Phe Leu Leu Gly Glu Glu Val Ala Gln Tyr Asp 
    50                  55                  60                  


Gly Ala Tyr Lys Val Ser Arg Gly Leu Trp Lys Lys Tyr Gly Asp Lys 
65                  70                  75                  80  


Arg Ile Ile Asp Thr Pro Ile Ser Glu Met Gly Phe Ala Gly Ile Ala 
                85                  90                  95      


Val Gly Ala Ala Met Ala Gly Leu Arg Pro Ile Cys Glu Phe Met Thr 
            100                 105                 110         


Phe Asn Phe Ser Met Gln Ala Ile Asp Gln Val Ile Asn Ser Ala Ala 
        115                 120                 125             


Lys Thr Tyr Tyr Met Ser Gly Gly Leu Gln Pro Val Pro Ile Val Phe 
    130                 135                 140                 


Arg Gly Pro Asn Gly Ala Ser Ala Gly Val Ala Ala Gln His Ser Gln 
145                 150                 155                 160 


Cys Phe Ala Ala Trp Tyr Gly His Cys Pro Gly Leu Lys Val Val Ser 
                165                 170                 175     


Pro Trp Asn Ser Glu Asp Ala Lys Gly Leu Ile Lys Ser Ala Ile Arg 
            180                 185                 190         


Asp Asn Asn Pro Val Val Val Leu Glu Asn Glu Leu Met Tyr Gly Val 
        195                 200                 205             


Pro Phe Glu Phe Pro Pro Glu Ala Gln Ser Lys Asp Phe Leu Ile Pro 
    210                 215                 220                 


Ile Gly Lys Ala Lys Ile Glu Arg Gln Gly Thr His Ile Thr Val Val 
225                 230                 235                 240 


Ser His Ser Arg Pro Val Gly His Cys Leu Glu Ala Ala Ala Val Leu 
                245                 250                 255     


Ser Lys Glu Gly Val Glu Cys Glu Val Ile Asn Met Arg Thr Ile Arg 
            260                 265                 270         


Pro Met Asp Met Glu Thr Ile Glu Ala Ser Val Met Lys Thr Asn His 
        275                 280                 285             


Leu Val Thr Val Glu Gly Gly Trp Pro Gln Phe Gly Val Gly Ala Glu 
    290                 295                 300                 


Ile Cys Ala Arg Ile Met Glu Gly Pro Ala Phe Asn Phe Leu Asp Ala 
305                 310                 315                 320 


Pro Ala Val Arg Val Thr Gly Ala Asp Val Pro Met Pro Tyr Ala Lys 
                325                 330                 335     


Ile Leu Glu Asp Asn Ser Ile Pro Gln Val Lys Asp Ile Ile Phe Ala 
            340                 345                 350         


Ile Lys Lys Thr Leu Asn Ile 
        355                 


<210>  63
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ser Pro Val Leu His Phe Tyr Val Arg Pro Ser Gly His Glu Gly 
1               5                   10                  15      


Ala Ala Pro Gly His Thr Arg Arg Lys Leu Gln Gly Lys Leu Pro Glu 
            20                  25                  30          


Leu Gln Gly Val Glu Thr Glu Leu Cys Tyr Asn Val Asn Trp Thr Ala 
        35                  40                  45              


Glu Ala Leu Pro Ser Ala Glu Glu Thr Lys Lys Leu Met Trp Leu Phe 
    50                  55                  60                  


Gly Cys Pro Leu Leu Leu Asp Asp Val Ala Arg Glu Ser Trp Leu Leu 
65                  70                  75                  80  


Pro Gly Ser Asn Asp Leu Leu Leu Glu Val Gly Pro Arg Leu Asn Phe 
                85                  90                  95      


Ser Thr Pro Thr Ser Thr Asn Ile Val Ser Val Cys Arg Ala Thr Gly 
            100                 105                 110         


Leu Gly Pro Val Asp Arg Val Glu Thr Thr Arg Arg Tyr Arg Leu Ser 
        115                 120                 125             


Phe Ala His Pro Pro Ser Ala Glu Val Glu Ala Ile Ala Leu Ala Thr 
    130                 135                 140                 


Leu His Asp Arg Met Thr Glu Gln His Phe Pro His Pro Ile Gln Ser 
145                 150                 155                 160 


Phe Ser Pro Glu Ser Met Pro Glu Pro Leu Asn Gly Pro Ile Asn Ile 
                165                 170                 175     


Leu Gly Glu Gly Arg Leu Ala Leu Glu Lys Ala Asn Gln Glu Leu Gly 
            180                 185                 190         


Leu Ala Leu Asp Ser Trp Asp Leu Asp Phe Tyr Thr Lys Arg Phe Gln 
        195                 200                 205             


Glu Leu Gln Arg Asn Pro Ser Thr Val Glu Ala Phe Asp Leu Ala Gln 
    210                 215                 220                 


Ser Asn Ser Glu His Ser Arg His Trp Phe Phe Lys Gly Gln Leu His 
225                 230                 235                 240 


Val Asp Gly Gln Lys Leu Val His Ser Leu Phe Glu Ser Ile Met Ser 
                245                 250                 255     


Thr Gln Glu Ser Ser Asn Pro Asn Asn Val Leu Lys Phe Cys Asp Asn 
            260                 265                 270         


Ser Ser Ala Ile Gln Gly Lys Glu Val Arg Phe Leu Arg Pro Glu Asp 
        275                 280                 285             


Pro Thr Arg Pro Ser Arg Phe Gln Gln Gln Gln Gly Leu Arg His Val 
    290                 295                 300                 


Val Phe Thr Ala Glu Thr His Asn Phe Pro Thr Gly Val Cys Pro Phe 
305                 310                 315                 320 


Ser Gly Ala Thr Thr Gly Thr Gly Gly Arg Ile Arg Asp Val Gln Cys 
                325                 330                 335     


Thr Gly Arg Gly Ala His Val Val Ala Gly Thr Ala Gly Tyr Cys Phe 
            340                 345                 350         


Gly Asn Leu His Ile Pro Gly Tyr Asn Leu Pro Trp Glu Asp Pro Ser 
        355                 360                 365             


Phe Gln Tyr Pro Gly Asn Phe Ala Arg Pro Leu Glu Val Ala Ile Glu 
    370                 375                 380                 


Ala Ser Asn Gly Ala Ser Asp Tyr Gly Asn Lys Phe Gly Glu Pro Val 
385                 390                 395                 400 


Leu Ala Gly Phe Ala Arg Ser Leu Gly Leu Gln Leu Pro Asp Gly Gln 
                405                 410                 415     


Arg Arg Glu Trp Ile Lys Pro Ile Met Phe Ser Gly Gly Ile Gly Ser 
            420                 425                 430         


Met Glu Ala Asp His Ile Ser Lys Glu Ala Pro Glu Pro Gly Met Glu 
        435                 440                 445             


Val Val Lys Val Gly Gly Pro Val Tyr Arg Ile Gly Val Gly Gly Gly 
    450                 455                 460                 


Ala Ala Ser Ser Val Gln Val Gln Gly Asp Asn Thr Ser Asp Leu Asp 
465                 470                 475                 480 


Phe Gly Ala Val Gln Arg Gly Asp Pro Glu Met Glu Gln Lys Met Asn 
                485                 490                 495     


Arg Val Ile Arg Ala Cys Val Glu Ala Pro Lys Gly Asn Pro Ile Cys 
            500                 505                 510         


Ser Leu His Asp Gln Gly Ala Gly Gly Asn Gly Asn Val Leu Lys Glu 
        515                 520                 525             


Leu Ser Asp Pro Ala Gly Ala Ile Ile Tyr Thr Ser Arg Phe Gln Leu 
    530                 535                 540                 


Gly Asp Pro Thr Leu Asn Ala Leu Glu Ile Trp Gly Ala Glu Tyr Gln 
545                 550                 555                 560 


Glu Ser Asn Ala Leu Leu Leu Arg Ser Pro Asn Arg Asp Phe Leu Thr 
                565                 570                 575     


His Val Ser Ala Arg Glu Arg Cys Pro Ala Cys Phe Val Gly Thr Ile 
            580                 585                 590         


Thr Gly Asp Arg Arg Ile Val Leu Val Asp Asp Arg Glu Cys Pro Val 
        595                 600                 605             


Arg Arg Asn Gly Gln Gly Asp Ala Pro Pro Thr Pro Leu Pro Thr Pro 
    610                 615                 620                 


Val Asp Leu Glu Leu Glu Trp Val Leu Gly Lys Met Pro Arg Lys Glu 
625                 630                 635                 640 


Phe Phe Leu Gln Arg Lys Pro Pro Met Leu Gln Pro Leu Ala Leu Pro 
                645                 650                 655     


Pro Gly Leu Ser Val His Gln Ala Leu Glu Arg Val Leu Arg Leu Pro 
            660                 665                 670         


Ala Val Ala Ser Lys Arg Tyr Leu Thr Asn Lys Val Asp Arg Ser Val 
        675                 680                 685             


Gly Gly Leu Val Ala Gln Gln Gln Cys Val Gly Pro Leu Gln Thr Pro 
    690                 695                 700                 


Leu Ala Asp Val Ala Val Val Ala Leu Ser His Glu Glu Leu Ile Gly 
705                 710                 715                 720 


Ala Ala Thr Ala Leu Gly Glu Gln Pro Val Lys Ser Leu Leu Asp Pro 
                725                 730                 735     


Lys Val Ala Ala Arg Leu Ala Val Ala Glu Ala Leu Thr Asn Leu Val 
            740                 745                 750         


Phe Ala Leu Val Thr Asp Leu Arg Asp Val Lys Cys Ser Gly Asn Trp 
        755                 760                 765             


Met Trp Ala Ala Lys Leu Pro Gly Glu Gly Ala Ala Leu Ala Asp Ala 
    770                 775                 780                 


Cys Glu Ala Met Val Ala Val Met Ala Ala Leu Gly Val Ala Val Asp 
785                 790                 795                 800 


Gly Gly Lys Asp Ser Leu Ser Met Ala Ala Arg Val Gly Thr Glu Thr 
                805                 810                 815     


Val Arg Ala Pro Gly Ser Leu Val Ile Ser Ala Tyr Ala Val Cys Pro 
            820                 825                 830         


Asp Ile Thr Ala Thr Val Thr Pro Asp Leu Lys His Pro Glu Gly Arg 
        835                 840                 845             


Gly His Leu Leu Tyr Val Ala Leu Ser Pro Gly Gln His Arg Leu Gly 
    850                 855                 860                 


Gly Thr Ala Leu Ala Gln Cys Phe Ser Gln Leu Gly Glu His Pro Pro 
865                 870                 875                 880 


Asp Leu Asp Leu Pro Glu Asn Leu Val Arg Ala Phe Ser Ile Thr Gln 
                885                 890                 895     


Gly Leu Leu Lys Asp Arg Leu Leu Cys Ser Gly His Asp Val Ser Asp 
            900                 905                 910         


Gly Gly Leu Val Thr Cys Leu Leu Glu Met Ala Phe Ala Gly Asn Cys 
        915                 920                 925             


Gly Leu Gln Val Asp Val Pro Val Pro Arg Val Asp Val Leu Ser Val 
    930                 935                 940                 


Leu Phe Ala Glu Glu Pro Gly Leu Val Leu Glu Val Gln Glu Pro Asp 
945                 950                 955                 960 


Leu Ala Gln Val Leu Lys Arg Tyr Arg Asp Ala Gly Leu His Cys Leu 
                965                 970                 975     


Glu Leu Gly His Thr Gly Glu Ala Gly Pro His Ala Met Val Arg Val 
            980                 985                 990         


Ser Val Asn Gly Ala Val Val Leu  Glu Glu Pro Val Gly  Glu Leu Arg 
        995                 1000                 1005             


Ala Leu  Trp Glu Glu Thr Ser  Phe Gln Leu Asp Arg  Leu Gln Ala 
    1010                 1015                 1020             


Glu Pro  Arg Cys Val Ala Glu  Glu Glu Arg Gly Leu  Arg Glu Arg 
    1025                 1030                 1035             


Met Gly  Pro Ser Tyr Cys Leu  Pro Pro Thr Phe Pro  Lys Ala Ser 
    1040                 1045                 1050             


Val Pro  Arg Glu Pro Gly Gly  Pro Ser Pro Arg Val  Ala Ile Leu 
    1055                 1060                 1065             


Arg Glu  Glu Gly Ser Asn Gly  Asp Arg Glu Met Ala  Asp Ala Phe 
    1070                 1075                 1080             


His Leu  Ala Gly Phe Glu Val  Trp Asp Val Thr Met  Gln Asp Leu 
    1085                 1090                 1095             


Cys Ser  Gly Ala Ile Gly Leu  Asp Thr Phe Arg Gly  Val Ala Phe 
    1100                 1105                 1110             


Val Gly  Gly Phe Ser Tyr Ala  Asp Val Leu Gly Ser  Ala Lys Gly 
    1115                 1120                 1125             


Trp Ala  Ala Ala Val Thr Phe  His Pro Arg Ala Gly  Ala Glu Leu 
    1130                 1135                 1140             


Arg Arg  Phe Arg Lys Arg Pro  Asp Thr Phe Ser Leu  Gly Val Cys 
    1145                 1150                 1155             


Asn Gly  Cys Gln Leu Leu Ala  Leu Leu Gly Trp Val  Gly Gly Asp 
    1160                 1165                 1170             


Pro Asn  Glu Asp Ala Ala Glu  Met Gly Pro Asp Ser  Gln Pro Ala 
    1175                 1180                 1185             


Arg Pro  Gly Leu Leu Leu Arg  His Asn Leu Ser Gly  Arg Tyr Glu 
    1190                 1195                 1200             


Ser Arg  Trp Ala Ser Val Arg  Val Gly Pro Gly Pro  Ala Leu Met 
    1205                 1210                 1215             


Leu Arg  Gly Met Glu Gly Ala  Val Leu Pro Val Trp  Ser Ala His 
    1220                 1225                 1230             


Gly Glu  Gly Tyr Val Ala Phe  Ser Ser Pro Glu Leu  Gln Ala Gln 
    1235                 1240                 1245             


Ile Glu  Ala Arg Gly Leu Ala  Pro Leu His Trp Ala  Asp Asp Asp 
    1250                 1255                 1260             


Gly Asn  Pro Thr Glu Gln Tyr  Pro Leu Asn Pro Asn  Gly Ser Pro 
    1265                 1270                 1275             


Gly Gly  Val Ala Gly Ile Cys  Ser Cys Asp Gly Arg  His Leu Ala 
    1280                 1285                 1290             


Val Met  Pro His Pro Glu Arg  Ala Val Arg Pro Trp  Gln Trp Ala 
    1295                 1300                 1305             


Trp Arg  Pro Pro Pro Phe Asp  Thr Leu Thr Thr Ser  Pro Trp Leu 
    1310                 1315                 1320             


Gln Leu  Phe Ile Asn Ala Arg  Asn Trp Thr Leu Glu  Gly Ser Cys 
    1325                 1330                 1335             


<210>  64
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Ala Gln Ala Asp Ile Ala Leu Ile Gly Leu Ala Val Met Gly Gln 
1               5                   10                  15      


Asn Leu Ile Leu Asn Met Asn Asp His Gly Phe Val Val Cys Ala Phe 
            20                  25                  30          


Asn Arg Thr Val Ser Lys Val Asp Asp Phe Leu Ala Asn Glu Ala Lys 
        35                  40                  45              


Gly Thr Lys Val Val Gly Ala Gln Ser Leu Lys Glu Met Val Ser Lys 
    50                  55                  60                  


Leu Lys Lys Pro Arg Arg Ile Ile Leu Leu Val Lys Ala Gly Gln Ala 
65                  70                  75                  80  


Val Asp Asp Phe Ile Glu Lys Leu Val Pro Leu Leu Asp Thr Gly Asp 
                85                  90                  95      


Ile Ile Ile Asp Gly Gly Asn Ser Glu Tyr Arg Asp Thr Thr Arg Arg 
            100                 105                 110         


Cys Arg Asp Leu Lys Ala Lys Gly Ile Leu Phe Val Gly Ser Gly Val 
        115                 120                 125             


Ser Gly Gly Glu Glu Gly Ala Arg Tyr Gly Pro Ser Leu Met Pro Gly 
    130                 135                 140                 


Gly Asn Lys Glu Ala Trp Pro His Ile Lys Thr Ile Phe Gln Gly Ile 
145                 150                 155                 160 


Ala Ala Lys Val Gly Thr Gly Glu Pro Cys Cys Asp Trp Val Gly Asp 
                165                 170                 175     


Glu Gly Ala Gly His Phe Val Lys Met Val His Asn Gly Ile Glu Tyr 
            180                 185                 190         


Gly Asp Met Gln Leu Ile Cys Glu Ala Tyr His Leu Met Lys Asp Val 
        195                 200                 205             


Leu Gly Met Ala Gln Asp Glu Met Ala Gln Ala Phe Glu Asp Trp Asn 
    210                 215                 220                 


Lys Thr Glu Leu Asp Ser Phe Leu Ile Glu Ile Thr Ala Asn Ile Leu 
225                 230                 235                 240 


Lys Phe Gln Asp Thr Asp Gly Lys His Leu Leu Pro Lys Ile Arg Asp 
                245                 250                 255     


Ser Ala Gly Gln Lys Gly Thr Gly Lys Trp Thr Ala Ile Ser Ala Leu 
            260                 265                 270         


Glu Tyr Gly Val Pro Val Thr Leu Ile Gly Glu Ala Val Phe Ala Arg 
        275                 280                 285             


Cys Leu Ser Ser Leu Lys Asp Glu Arg Ile Gln Ala Ser Lys Lys Leu 
    290                 295                 300                 


Lys Gly Pro Gln Lys Phe Gln Phe Asp Gly Asp Lys Lys Ser Phe Leu 
305                 310                 315                 320 


Glu Asp Ile Arg Lys Ala Leu Tyr Ala Ser Lys Ile Ile Ser Tyr Ala 
                325                 330                 335     


Gln Gly Phe Met Leu Leu Arg Gln Ala Ala Thr Glu Phe Gly Trp Thr 
            340                 345                 350         


Leu Asn Tyr Gly Gly Ile Ala Leu Met Trp Arg Gly Gly Cys Ile Ile 
        355                 360                 365             


Arg Ser Val Phe Leu Gly Lys Ile Lys Asp Ala Phe Asp Arg Asn Pro 
    370                 375                 380                 


Glu Leu Gln Asn Leu Leu Leu Asp Asp Phe Phe Lys Ser Ala Val Glu 
385                 390                 395                 400 


Asn Cys Gln Asp Ser Trp Arg Arg Ala Val Ser Thr Gly Val Gln Ala 
                405                 410                 415     


Gly Ile Pro Met Pro Cys Phe Thr Thr Ala Leu Ser Phe Tyr Asp Gly 
            420                 425                 430         


Tyr Arg His Glu Met Leu Pro Ala Ser Leu Ile Gln Ala Gln Arg Asp 
        435                 440                 445             


Tyr Phe Gly Ala His Thr Tyr Glu Leu Leu Ala Lys Pro Gly Gln Phe 
    450                 455                 460                 


Ile His Thr Asn Trp Thr Gly His Gly Gly Thr Val Ser Ser Ser Ser 
465                 470                 475                 480 


Tyr Asn Ala 
            


<210>  65
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Ala Ala Glu Ala Gly Gly Asp Asp Ala Arg Cys Val Arg Leu 
1               5                   10                  15      


Ser Ala Glu Arg Ala Gln Ala Leu Leu Ala Asp Val Asp Thr Leu Leu 
            20                  25                  30          


Phe Asp Cys Asp Gly Val Leu Trp Arg Gly Glu Thr Ala Val Pro Gly 
        35                  40                  45              


Ala Pro Glu Ala Leu Arg Ala Leu Arg Ala Arg Gly Lys Arg Leu Gly 
    50                  55                  60                  


Phe Ile Thr Asn Asn Ser Ser Lys Thr Arg Ala Ala Tyr Ala Glu Lys 
65                  70                  75                  80  


Leu Arg Arg Leu Gly Phe Gly Gly Pro Ala Gly Pro Gly Ala Ser Leu 
                85                  90                  95      


Glu Val Phe Gly Thr Ala Tyr Cys Thr Ala Leu Tyr Leu Arg Gln Arg 
            100                 105                 110         


Leu Ala Gly Ala Pro Ala Pro Lys Ala Tyr Val Leu Gly Ser Pro Ala 
        115                 120                 125             


Leu Ala Ala Glu Leu Glu Ala Val Gly Val Ala Ser Val Gly Val Gly 
    130                 135                 140                 


Pro Glu Pro Leu Gln Gly Glu Gly Pro Gly Asp Trp Leu His Ala Pro 
145                 150                 155                 160 


Leu Glu Pro Asp Val Arg Ala Val Val Val Gly Phe Asp Pro His Phe 
                165                 170                 175     


Ser Tyr Met Lys Leu Thr Lys Ala Leu Arg Tyr Leu Gln Gln Pro Gly 
            180                 185                 190         


Cys Leu Leu Val Gly Thr Asn Met Asp Asn Arg Leu Pro Leu Glu Asn 
        195                 200                 205             


Gly Arg Phe Ile Ala Gly Thr Gly Cys Leu Val Arg Ala Val Glu Met 
    210                 215                 220                 


Ala Ala Gln Arg Gln Ala Asp Ile Ile Gly Lys Pro Ser Arg Phe Ile 
225                 230                 235                 240 


Phe Asp Cys Val Ser Gln Glu Tyr Gly Ile Asn Pro Glu Arg Thr Val 
                245                 250                 255     


Met Val Gly Asp Arg Leu Asp Thr Asp Ile Leu Leu Gly Ala Thr Cys 
            260                 265                 270         


Gly Leu Lys Thr Ile Leu Thr Leu Thr Gly Val Ser Thr Leu Gly Asp 
        275                 280                 285             


Val Lys Asn Asn Gln Glu Ser Asp Cys Val Ser Lys Lys Lys Met Val 
    290                 295                 300                 


Pro Asp Phe Tyr Val Asp Ser Ile Ala Asp Leu Leu Pro Ala Leu Gln 
305                 310                 315                 320 


Gly 
    


<210>  66
<211>  2102
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Ala Ala Pro Ala Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Cys Ser Gly Ser Gly Ser Ser Ala Ser Arg Gly Phe Tyr Phe 
            20                  25                  30          


Asn Thr Val Leu Ser Leu Ala Arg Ser Leu Ala Val Gln Arg Pro Ala 
        35                  40                  45              


Ser Leu Glu Lys Val Gln Lys Leu Leu Cys Met Cys Pro Val Asp Phe 
    50                  55                  60                  


His Gly Ile Phe Gln Leu Asp Glu Arg Arg Arg Asp Ala Val Ile Ala 
65                  70                  75                  80  


Leu Gly Ile Phe Leu Ile Glu Ser Asp Leu Gln His Lys Asp Cys Val 
                85                  90                  95      


Val Pro Tyr Leu Leu Arg Leu Leu Lys Gly Leu Pro Lys Val Tyr Trp 
            100                 105                 110         


Val Glu Glu Ser Thr Ala Arg Lys Gly Arg Gly Ala Leu Pro Val Ala 
        115                 120                 125             


Glu Ser Phe Ser Phe Cys Leu Val Thr Leu Leu Ser Asp Val Ala Tyr 
    130                 135                 140                 


Arg Asp Pro Ser Leu Arg Asp Glu Ile Leu Glu Val Leu Leu Gln Val 
145                 150                 155                 160 


Leu His Val Leu Leu Gly Met Cys Gln Ala Leu Glu Ile Gln Asp Lys 
                165                 170                 175     


Glu Tyr Leu Cys Lys Tyr Ala Ile Pro Cys Leu Ile Gly Ile Ser Arg 
            180                 185                 190         


Ala Phe Gly Arg Tyr Ser Asn Met Glu Glu Ser Leu Leu Ser Lys Leu 
        195                 200                 205             


Phe Pro Lys Ile Pro Pro His Ser Leu Arg Val Leu Glu Glu Leu Glu 
    210                 215                 220                 


Gly Val Arg Arg Arg Ser Phe Asn Asp Phe Arg Ser Ile Leu Pro Ser 
225                 230                 235                 240 


Asn Leu Leu Thr Val Cys Gln Glu Gly Thr Leu Lys Arg Lys Thr Ser 
                245                 250                 255     


Ser Val Ser Ser Ile Ser Gln Val Ser Pro Glu Arg Gly Met Pro Pro 
            260                 265                 270         


Pro Ser Ser Pro Gly Gly Ser Ala Phe His Tyr Phe Glu Ala Ser Cys 
        275                 280                 285             


Leu Pro Asp Gly Thr Ala Leu Glu Pro Glu Tyr Tyr Phe Ser Thr Ile 
    290                 295                 300                 


Ser Ser Ser Phe Ser Val Ser Pro Leu Phe Asn Gly Val Thr Tyr Lys 
305                 310                 315                 320 


Glu Phe Asn Ile Pro Leu Glu Met Leu Arg Glu Leu Leu Asn Leu Val 
                325                 330                 335     


Lys Lys Ile Val Glu Glu Ala Val Leu Lys Ser Leu Asp Ala Ile Val 
            340                 345                 350         


Ala Ser Val Met Glu Ala Asn Pro Ser Ala Asp Leu Tyr Tyr Thr Ser 
        355                 360                 365             


Phe Ser Asp Pro Leu Tyr Leu Thr Met Phe Lys Met Leu Arg Asp Thr 
    370                 375                 380                 


Leu Tyr Tyr Met Lys Asp Leu Pro Thr Ser Phe Val Lys Glu Ile His 
385                 390                 395                 400 


Asp Phe Val Leu Glu Gln Phe Asn Thr Ser Gln Gly Glu Leu Gln Lys 
                405                 410                 415     


Ile Leu His Asp Ala Asp Arg Ile His Asn Glu Leu Ser Pro Leu Lys 
            420                 425                 430         


Leu Arg Cys Gln Ala Asn Ala Ala Cys Val Asp Leu Met Val Trp Ala 
        435                 440                 445             


Val Lys Asp Glu Gln Gly Ala Glu Asn Leu Cys Ile Lys Leu Ser Glu 
    450                 455                 460                 


Lys Leu Gln Ser Lys Thr Ser Ser Lys Val Ile Ile Ala His Leu Pro 
465                 470                 475                 480 


Leu Leu Ile Cys Cys Leu Gln Gly Leu Gly Arg Leu Cys Glu Arg Phe 
                485                 490                 495     


Pro Val Val Val His Ser Val Thr Pro Ser Leu Arg Asp Phe Leu Val 
            500                 505                 510         


Ile Pro Ser Pro Val Leu Val Lys Leu Tyr Lys Tyr His Ser Gln Tyr 
        515                 520                 525             


His Thr Val Ala Gly Asn Asp Ile Lys Ile Ser Val Thr Asn Glu His 
    530                 535                 540                 


Ser Glu Ser Thr Leu Asn Val Met Ser Gly Lys Lys Ser Gln Pro Ser 
545                 550                 555                 560 


Met Tyr Glu Gln Leu Arg Asp Ile Ala Ile Asp Asn Ile Cys Arg Cys 
                565                 570                 575     


Leu Lys Ala Gly Leu Thr Val Asp Pro Val Ile Val Glu Ala Phe Leu 
            580                 585                 590         


Ala Ser Leu Ser Asn Arg Leu Tyr Ile Ser Gln Glu Ser Asp Lys Asp 
        595                 600                 605             


Ala His Leu Ile Pro Asp His Thr Ile Arg Ala Leu Gly His Ile Ala 
    610                 615                 620                 


Val Ala Leu Arg Asp Thr Pro Lys Val Met Glu Pro Ile Leu Gln Ile 
625                 630                 635                 640 


Leu Gln Gln Lys Phe Cys Gln Pro Pro Ser Pro Leu Asp Val Leu Ile 
                645                 650                 655     


Ile Asp Gln Leu Gly Cys Leu Val Ile Thr Gly Asn Gln Tyr Ile Tyr 
            660                 665                 670         


Gln Glu Val Trp Asn Leu Phe Gln Gln Ile Ser Val Lys Ala Ser Ser 
        675                 680                 685             


Val Val Tyr Ser Ala Thr Lys Asp Tyr Lys Asp His Gly Tyr Arg His 
    690                 695                 700                 


Cys Ser Leu Ala Val Ile Asn Ala Leu Ala Asn Ile Ala Ala Asn Ile 
705                 710                 715                 720 


Gln Asp Glu His Leu Val Asp Glu Leu Leu Met Asn Leu Leu Glu Leu 
                725                 730                 735     


Phe Val Gln Leu Gly Leu Glu Gly Lys Arg Ala Ser Glu Arg Ala Ser 
            740                 745                 750         


Glu Lys Gly Pro Ala Leu Lys Ala Ser Ser Ser Ala Gly Asn Leu Gly 
        755                 760                 765             


Val Leu Ile Pro Val Ile Ala Val Leu Thr Arg Arg Leu Pro Pro Ile 
    770                 775                 780                 


Lys Glu Ala Lys Pro Arg Leu Gln Lys Leu Phe Arg Asp Phe Trp Leu 
785                 790                 795                 800 


Tyr Ser Val Leu Met Gly Phe Ala Val Glu Gly Ser Gly Leu Trp Pro 
                805                 810                 815     


Glu Glu Trp Tyr Glu Gly Val Cys Glu Ile Ala Thr Lys Ser Pro Leu 
            820                 825                 830         


Leu Thr Phe Pro Ser Lys Glu Pro Leu Arg Ser Val Leu Gln Tyr Asn 
        835                 840                 845             


Ser Ala Met Lys Asn Asp Thr Val Thr Pro Ala Glu Leu Ser Glu Leu 
    850                 855                 860                 


Arg Ser Thr Ile Ile Asn Leu Leu Asp Pro Pro Pro Glu Val Ser Ala 
865                 870                 875                 880 


Leu Ile Asn Lys Leu Asp Phe Ala Met Ser Thr Tyr Leu Leu Ser Val 
                885                 890                 895     


Tyr Arg Leu Glu Tyr Met Arg Val Leu Arg Ser Thr Asp Pro Asp Arg 
            900                 905                 910         


Phe Gln Val Met Phe Cys Tyr Phe Glu Asp Lys Ala Ile Gln Lys Asp 
        915                 920                 925             


Lys Ser Gly Met Met Gln Cys Val Ile Ala Val Ala Asp Lys Val Phe 
    930                 935                 940                 


Asp Ala Phe Leu Asn Met Met Ala Asp Lys Ala Lys Thr Lys Glu Asn 
945                 950                 955                 960 


Glu Glu Glu Leu Glu Arg His Ala Gln Phe Leu Leu Val Asn Phe Asn 
                965                 970                 975     


His Ile His Lys Arg Ile Arg Arg Val Ala Asp Lys Tyr Leu Ser Gly 
            980                 985                 990         


Leu Val Asp Lys Phe Pro His Leu  Leu Trp Ser Gly Thr  Val Leu Lys 
        995                 1000                 1005             


Thr Met  Leu Asp Ile Leu Gln  Thr Leu Ser Leu Ser  Leu Ser Ala 
    1010                 1015                 1020             


Asp Ile  His Lys Asp Gln Pro  Tyr Tyr Asp Ile Pro  Asp Ala Pro 
    1025                 1030                 1035             


Tyr Arg  Ile Thr Val Pro Asp  Thr Tyr Glu Ala Arg  Glu Ser Ile 
    1040                 1045                 1050             


Val Lys  Asp Phe Ala Ala Arg  Cys Gly Met Ile Leu  Gln Glu Ala 
    1055                 1060                 1065             


Met Lys  Trp Ala Pro Thr Val  Thr Lys Ser His Leu  Gln Glu Tyr 
    1070                 1075                 1080             


Leu Asn  Lys His Gln Asn Trp  Val Ser Gly Leu Ser  Gln His Thr 
    1085                 1090                 1095             


Gly Leu  Ala Met Ala Thr Glu  Ser Ile Leu His Phe  Ala Gly Tyr 
    1100                 1105                 1110             


Asn Lys  Gln Asn Thr Thr Leu  Gly Ala Thr Gln Leu  Ser Glu Arg 
    1115                 1120                 1125             


Pro Ala  Cys Val Lys Lys Asp  Tyr Ser Asn Phe Met  Ala Ser Leu 
    1130                 1135                 1140             


Asn Leu  Arg Asn Arg Tyr Ala  Gly Glu Val Tyr Gly  Met Ile Arg 
    1145                 1150                 1155             


Phe Ser  Gly Thr Thr Gly Gln  Met Ser Asp Leu Asn  Lys Met Met 
    1160                 1165                 1170             


Val Gln  Asp Leu His Ser Ala  Leu Asp Arg Ser His  Pro Gln His 
    1175                 1180                 1185             


Tyr Thr  Gln Ala Met Phe Lys  Leu Thr Ala Met Leu  Ile Ser Ser 
    1190                 1195                 1200             


Lys Asp  Cys Asp Pro Gln Leu  Leu His His Leu Cys  Trp Gly Pro 
    1205                 1210                 1215             


Leu Arg  Met Phe Asn Glu His  Gly Met Glu Thr Ala  Leu Ala Cys 
    1220                 1225                 1230             


Trp Glu  Trp Leu Leu Ala Gly  Lys Asp Gly Val Glu  Val Pro Phe 
    1235                 1240                 1245             


Met Arg  Glu Met Ala Gly Ala  Trp His Met Thr Val  Glu Gln Lys 
    1250                 1255                 1260             


Phe Gly  Leu Phe Ser Ala Glu  Ile Lys Glu Ala Asp  Pro Leu Ala 
    1265                 1270                 1275             


Ala Ser  Glu Ala Ser Gln Pro  Lys Pro Cys Pro Pro  Glu Val Thr 
    1280                 1285                 1290             


Pro His  Tyr Ile Trp Ile Asp  Phe Leu Val Gln Arg  Phe Glu Ile 
    1295                 1300                 1305             


Ala Lys  Tyr Cys Ser Ser Asp  Gln Val Glu Ile Phe  Ser Ser Leu 
    1310                 1315                 1320             


Leu Gln  Arg Ser Met Ser Leu  Asn Ile Gly Gly Ala  Lys Gly Ser 
    1325                 1330                 1335             


Met Asn  Arg His Val Ala Ala  Ile Gly Pro Arg Phe  Lys Leu Leu 
    1340                 1345                 1350             


Thr Leu  Gly Leu Ser Leu Leu  His Ala Asp Val Val  Pro Asn Ala 
    1355                 1360                 1365             


Thr Ile  Arg Asn Val Leu Arg  Glu Lys Ile Tyr Ser  Thr Ala Phe 
    1370                 1375                 1380             


Asp Tyr  Phe Ser Cys Pro Pro  Lys Phe Pro Thr Gln  Gly Glu Lys 
    1385                 1390                 1395             


Arg Leu  Arg Glu Asp Ile Ser  Ile Met Ile Lys Phe  Trp Thr Ala 
    1400                 1405                 1410             


Met Phe  Ser Asp Lys Lys Tyr  Leu Thr Ala Ser Gln  Leu Val Pro 
    1415                 1420                 1425             


Pro Asp  Asn Gln Asp Thr Arg  Ser Asn Leu Asp Ile  Thr Val Gly 
    1430                 1435                 1440             


Ser Arg  Gln Gln Ala Thr Gln  Gly Trp Ile Asn Thr  Tyr Pro Leu 
    1445                 1450                 1455             


Ser Ser  Gly Met Ser Thr Ile  Ser Lys Lys Ser Gly  Met Ser Lys 
    1460                 1465                 1470             


Lys Thr  Asn Arg Gly Ser Gln  Leu His Lys Tyr Tyr  Met Lys Arg 
    1475                 1480                 1485             


Arg Thr  Leu Leu Leu Ser Leu  Leu Ala Thr Glu Ile  Glu Arg Leu 
    1490                 1495                 1500             


Ile Thr  Trp Tyr Asn Pro Leu  Ser Ala Pro Glu Leu  Glu Leu Asp 
    1505                 1510                 1515             


Gln Ala  Gly Glu Asn Ser Val  Ala Asn Trp Arg Ser  Lys Tyr Ile 
    1520                 1525                 1530             


Ser Leu  Ser Glu Lys Gln Trp  Lys Asp Asn Val Asn  Leu Ala Trp 
    1535                 1540                 1545             


Ser Ile  Ser Pro Tyr Leu Ala  Val Gln Leu Pro Ala  Arg Phe Lys 
    1550                 1555                 1560             


Asn Thr  Glu Ala Ile Gly Asn  Glu Val Thr Arg Leu  Val Arg Leu 
    1565                 1570                 1575             


Asp Pro  Gly Ala Val Ser Asp  Val Pro Glu Ala Ile  Lys Phe Leu 
    1580                 1585                 1590             


Val Thr  Trp His Thr Ile Asp  Ala Asp Ala Pro Glu  Leu Ser His 
    1595                 1600                 1605             


Val Leu  Cys Trp Ala Pro Thr  Asp Pro Pro Thr Gly  Leu Ser Tyr 
    1610                 1615                 1620             


Phe Ser  Ser Met Tyr Pro Pro  His Pro Leu Thr Ala  Gln Tyr Gly 
    1625                 1630                 1635             


Val Lys  Val Leu Arg Ser Phe  Pro Pro Asp Ala Ile  Leu Phe Tyr 
    1640                 1645                 1650             


Ile Pro  Gln Ile Val Gln Ala  Leu Arg Tyr Asp Lys  Met Gly Tyr 
    1655                 1660                 1665             


Val Arg  Glu Tyr Ile Leu Trp  Ala Ala Ser Lys Ser  Gln Leu Leu 
    1670                 1675                 1680             


Ala His  Gln Phe Ile Trp Asn  Met Lys Thr Asn Ile  Tyr Leu Asp 
    1685                 1690                 1695             


Glu Glu  Gly His Gln Lys Asp  Pro Asp Ile Gly Asp  Leu Leu Asp 
    1700                 1705                 1710             


Gln Leu  Val Glu Glu Ile Thr  Gly Ser Leu Ser Gly  Pro Ala Lys 
    1715                 1720                 1725             


Asp Phe  Tyr Gln Arg Glu Phe  Asp Phe Phe Asn Lys  Ile Thr Asn 
    1730                 1735                 1740             


Val Ser  Ala Ile Ile Lys Pro  Tyr Pro Lys Gly Asp  Glu Arg Lys 
    1745                 1750                 1755             


Lys Ala  Cys Leu Ser Ala Leu  Ser Glu Val Lys Val  Gln Pro Gly 
    1760                 1765                 1770             


Cys Tyr  Leu Pro Ser Asn Pro  Glu Ala Ile Val Leu  Asp Ile Asp 
    1775                 1780                 1785             


Tyr Lys  Ser Gly Thr Pro Met  Gln Ser Ala Ala Lys  Ala Pro Tyr 
    1790                 1795                 1800             


Leu Ala  Lys Phe Lys Val Lys  Arg Cys Gly Val Ser  Glu Leu Glu 
    1805                 1810                 1815             


Lys Glu  Gly Leu Arg Cys Arg  Ser Asp Ser Glu Asp  Glu Cys Ser 
    1820                 1825                 1830             


Thr Gln  Glu Ala Asp Gly Gln  Lys Ile Ser Trp Gln  Ala Ala Ile 
    1835                 1840                 1845             


Phe Lys  Val Gly Asp Asp Cys  Arg Gln Asp Met Leu  Ala Leu Gln 
    1850                 1855                 1860             


Ile Ile  Asp Leu Phe Lys Asn  Ile Phe Gln Leu Val  Gly Leu Asp 
    1865                 1870                 1875             


Leu Phe  Val Phe Pro Tyr Arg  Val Val Ala Thr Ala  Pro Gly Cys 
    1880                 1885                 1890             


Gly Val  Ile Glu Cys Ile Pro  Asp Cys Thr Ser Arg  Asp Gln Leu 
    1895                 1900                 1905             


Gly Arg  Gln Thr Asp Phe Gly  Met Tyr Asp Tyr Phe  Thr Arg Gln 
    1910                 1915                 1920             


Tyr Gly  Asp Glu Ser Thr Leu  Ala Phe Gln Gln Ala  Arg Tyr Asn 
    1925                 1930                 1935             


Phe Ile  Arg Ser Met Ala Ala  Tyr Ser Leu Leu Leu  Phe Leu Leu 
    1940                 1945                 1950             


Gln Ile  Lys Asp Arg His Asn  Gly Asn Ile Met Leu  Asp Lys Lys 
    1955                 1960                 1965             


Gly His  Ile Ile His Ile Asp  Phe Gly Phe Met Phe  Glu Ser Ser 
    1970                 1975                 1980             


Pro Gly  Gly Asn Leu Gly Trp  Glu Pro Asp Ile Lys  Leu Thr Asp 
    1985                 1990                 1995             


Glu Met  Val Met Ile Met Gly  Gly Lys Met Glu Ala  Thr Pro Phe 
    2000                 2005                 2010             


Lys Trp  Phe Met Glu Met Cys  Val Arg Gly Tyr Leu  Ala Val Arg 
    2015                 2020                 2025             


Pro Tyr  Met Asp Ala Val Val  Ser Leu Val Thr Leu  Met Leu Asp 
    2030                 2035                 2040             


Thr Gly  Leu Pro Cys Phe Arg  Gly Gln Thr Ile Lys  Leu Leu Lys 
    2045                 2050                 2055             


His Arg  Phe Ser Pro Asn Met  Thr Glu Arg Glu Ala  Ala Asn Phe 
    2060                 2065                 2070             


Ile Met  Lys Val Ile Gln Ser  Cys Phe Leu Ser Asn  Arg Ser Arg 
    2075                 2080                 2085             


Thr Tyr  Asp Met Ile Gln Tyr  Tyr Gln Asn Asp Ile  Pro Tyr 
    2090                 2095                 2100         


<210>  67
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Gly Asp Thr Val Val Glu Pro Ala Pro Leu Lys Pro Thr Ser Glu 
1               5                   10                  15      


Pro Thr Ser Gly Pro Pro Gly Asn Asn Gly Gly Ser Leu Leu Ser Val 
            20                  25                  30          


Ile Thr Glu Gly Val Gly Glu Leu Ser Val Ile Asp Pro Glu Val Ala 
        35                  40                  45              


Gln Lys Ala Cys Gln Glu Val Leu Glu Lys Val Lys Leu Leu His Gly 
    50                  55                  60                  


Gly Val Ala Val Ser Ser Arg Gly Thr Pro Leu Glu Leu Val Asn Gly 
65                  70                  75                  80  


Asp Gly Val Asp Ser Glu Ile Arg Cys Leu Asp Asp Pro Pro Ala Gln 
                85                  90                  95      


Ile Arg Glu Glu Glu Asp Glu Met Gly Ala Ala Val Ala Ser Gly Thr 
            100                 105                 110         


Ala Lys Gly Ala Arg Arg Arg Arg Gln Asn Asn Ser Ala Lys Gln Ser 
        115                 120                 125             


Trp Leu Leu Arg Leu Phe Glu Ser Lys Leu Phe Asp Ile Ser Met Ala 
    130                 135                 140                 


Ile Ser Tyr Leu Tyr Asn Ser Lys Glu Pro Gly Val Gln Ala Tyr Ile 
145                 150                 155                 160 


Gly Asn Arg Leu Phe Cys Phe Arg Asn Glu Asp Val Asp Phe Tyr Leu 
                165                 170                 175     


Pro Gln Leu Leu Asn Met Tyr Ile His Met Asp Glu Asp Val Gly Asp 
            180                 185                 190         


Ala Ile Lys Pro Tyr Ile Val His Arg Cys Arg Gln Ser Ile Asn Phe 
        195                 200                 205             


Ser Leu Gln Cys Ala Leu Leu Leu Gly Ala Tyr Ser Ser Asp Met His 
    210                 215                 220                 


Ile Ser Thr Gln Arg His Ser Arg Gly Thr Lys Leu Arg Lys Leu Ile 
225                 230                 235                 240 


Leu Ser Asp Glu Leu Lys Pro Ala His Arg Lys Arg Glu Leu Pro Ser 
                245                 250                 255     


Leu Ser Pro Ala Pro Asp Thr Gly Leu Ser Pro Ser Lys Arg Thr His 
            260                 265                 270         


Gln Arg Ser Lys Ser Asp Ala Thr Ala Ser Ile Ser Leu Ser Ser Asn 
        275                 280                 285             


Leu Lys Arg Thr Ala Ser Asn Pro Lys Val Glu Asn Glu Asp Glu Glu 
    290                 295                 300                 


Leu Ser Ser Ser Thr Glu Ser Ile Asp Asn Ser Phe Ser Ser Pro Val 
305                 310                 315                 320 


Arg Leu Ala Pro Glu Arg Glu Phe Ile Lys Ser Leu Met Ala Ile Gly 
                325                 330                 335     


Lys Arg Leu Ala Thr Leu Pro Thr Lys Glu Gln Lys Thr Gln Arg Leu 
            340                 345                 350         


Ile Ser Glu Leu Ser Leu Leu Asn His Lys Leu Pro Ala Arg Val Trp 
        355                 360                 365             


Leu Pro Thr Ala Gly Phe Asp His His Val Val Arg Val Pro His Thr 
    370                 375                 380                 


Gln Ala Val Val Leu Asn Ser Lys Asp Lys Ala Pro Tyr Leu Ile Tyr 
385                 390                 395                 400 


Val Glu Val Leu Glu Cys Glu Asn Phe Asp Thr Thr Ser Val Pro Ala 
                405                 410                 415     


Arg Ile Pro Glu Asn Arg Ile Arg Ser Thr Arg Ser Val Glu Asn Leu 
            420                 425                 430         


Pro Glu Cys Gly Ile Thr His Glu Gln Arg Ala Gly Ser Phe Ser Thr 
        435                 440                 445             


Val Pro Asn Tyr Asp Asn Asp Asp Glu Ala Trp Ser Val Asp Asp Ile 
    450                 455                 460                 


Gly Glu Leu Gln Val Glu Leu Pro Glu Val His Thr Asn Ser Cys Asp 
465                 470                 475                 480 


Asn Ile Ser Gln Phe Ser Val Asp Ser Ile Thr Ser Gln Glu Ser Lys 
                485                 490                 495     


Glu Pro Val Phe Ile Ala Ala Gly Asp Ile Arg Arg Arg Leu Ser Glu 
            500                 505                 510         


Gln Leu Ala His Thr Pro Thr Ala Phe Lys Arg Asp Pro Glu Asp Pro 
        515                 520                 525             


Ser Ala Val Ala Leu Lys Glu Pro Trp Gln Glu Lys Val Arg Arg Ile 
    530                 535                 540                 


Arg Glu Gly Ser Pro Tyr Gly His Leu Pro Asn Trp Arg Leu Leu Ser 
545                 550                 555                 560 


Val Ile Val Lys Cys Gly Asp Asp Leu Arg Gln Glu Leu Leu Ala Phe 
                565                 570                 575     


Gln Val Leu Lys Gln Leu Gln Ser Ile Trp Glu Gln Glu Arg Val Pro 
            580                 585                 590         


Leu Trp Ile Lys Pro Tyr Lys Ile Leu Val Ile Ser Ala Asp Ser Gly 
        595                 600                 605             


Met Ile Glu Pro Val Val Asn Ala Val Ser Ile His Gln Val Lys Lys 
    610                 615                 620                 


Gln Ser Gln Leu Ser Leu Leu Asp Tyr Phe Leu Gln Glu His Gly Ser 
625                 630                 635                 640 


Tyr Thr Thr Glu Ala Phe Leu Ser Ala Gln Arg Asn Phe Val Gln Ser 
                645                 650                 655     


Cys Ala Gly Tyr Cys Leu Val Cys Tyr Leu Leu Gln Val Lys Asp Arg 
            660                 665                 670         


His Asn Gly Asn Ile Leu Leu Asp Ala Glu Gly His Ile Ile His Ile 
        675                 680                 685             


Asp Phe Gly Phe Ile Leu Ser Ser Ser Pro Arg Asn Leu Gly Phe Glu 
    690                 695                 700                 


Thr Ser Ala Phe Lys Leu Thr Thr Glu Phe Val Asp Val Met Gly Gly 
705                 710                 715                 720 


Leu Asp Gly Asp Met Phe Asn Tyr Tyr Lys Met Leu Met Leu Gln Gly 
                725                 730                 735     


Leu Ile Ala Ala Arg Lys His Met Asp Lys Val Val Gln Ile Val Glu 
            740                 745                 750         


Ile Met Gln Gln Gly Ser Gln Leu Pro Cys Phe His Gly Ser Ser Thr 
        755                 760                 765             


Ile Arg Asn Leu Lys Glu Arg Phe His Met Ser Met Thr Glu Glu Gln 
    770                 775                 780                 


Leu Gln Leu Leu Val Glu Gln Met Val Asp Gly Ser Met Arg Ser Ile 
785                 790                 795                 800 


Thr Thr Lys Leu Tyr Asp Gly Phe Gln Tyr Leu Thr Asn Gly Ile Met 
                805                 810                 815     


<210>  68
<211>  1358
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly Asn Gln Leu Ala Gly Ile Ala Pro Ser Gln Ile Leu Ser Val 
1               5                   10                  15      


Glu Ser Tyr Phe Ser Asp Ile His Asp Phe Glu Tyr Asp Lys Ser Leu 
            20                  25                  30          


Gly Ser Thr Arg Phe Phe Lys Val Ala Arg Ala Lys His Arg Glu Gly 
        35                  40                  45              


Leu Val Val Val Lys Val Phe Ala Ile Gln Asp Pro Thr Leu Pro Leu 
    50                  55                  60                  


Thr Ser Tyr Lys Gln Glu Leu Glu Glu Leu Lys Ile Arg Leu Asn Ser 
65                  70                  75                  80  


Ala Gln Asn Cys Leu Pro Phe Gln Lys Ala Ser Glu Lys Ala Ser Glu 
                85                  90                  95      


Lys Ala Ala Met Leu Phe Arg Gln Tyr Val Arg Asp Asn Leu Tyr Asp 
            100                 105                 110         


Arg Ile Ser Thr Arg Pro Phe Leu Asn Asn Ile Glu Lys Arg Trp Ile 
        115                 120                 125             


Ala Phe Gln Ile Leu Thr Ala Val Asp Gln Ala His Lys Ser Gly Val 
    130                 135                 140                 


Arg His Gly Asp Ile Lys Thr Glu Asn Val Met Val Thr Ser Trp Asn 
145                 150                 155                 160 


Trp Val Leu Leu Thr Asp Phe Ala Ser Phe Lys Pro Thr Tyr Leu Pro 
                165                 170                 175     


Glu Asp Asn Pro Ala Asp Phe Asn Tyr Phe Phe Asp Thr Ser Arg Arg 
            180                 185                 190         


Arg Thr Cys Tyr Ile Ala Pro Glu Arg Phe Val Asp Gly Gly Met Phe 
        195                 200                 205             


Ala Thr Glu Leu Glu Tyr Met Arg Asp Pro Ser Thr Pro Leu Val Asp 
    210                 215                 220                 


Leu Asn Ser Asn Gln Arg Thr Arg Gly Glu Leu Lys Arg Ala Met Asp 
225                 230                 235                 240 


Ile Phe Ser Ala Gly Cys Val Ile Ala Glu Leu Phe Thr Glu Gly Val 
                245                 250                 255     


Pro Leu Phe Asp Leu Ser Gln Leu Leu Ala Tyr Arg Asn Gly His Phe 
            260                 265                 270         


Phe Pro Glu Gln Val Leu Asn Lys Ile Glu Asp His Ser Ile Arg Glu 
        275                 280                 285             


Leu Val Thr Gln Met Ile His Arg Glu Pro Asp Lys Arg Leu Glu Ala 
    290                 295                 300                 


Glu Asp Tyr Leu Lys Gln Gln Arg Gly Asn Ala Phe Pro Glu Ile Phe 
305                 310                 315                 320 


Tyr Thr Phe Leu Gln Pro Tyr Met Ala Gln Phe Ala Lys Glu Thr Phe 
                325                 330                 335     


Leu Ser Ala Asp Glu Arg Ile Leu Val Ile Arg Lys Asp Leu Gly Asn 
            340                 345                 350         


Ile Ile His Asn Leu Cys Gly His Asp Leu Pro Glu Lys Ala Glu Gly 
        355                 360                 365             


Glu Pro Lys Glu Asn Gly Leu Val Ile Leu Val Ser Val Ile Thr Ser 
    370                 375                 380                 


Cys Leu Gln Thr Leu Lys Tyr Cys Asp Ser Lys Leu Ala Ala Leu Glu 
385                 390                 395                 400 


Leu Ile Leu His Leu Ala Pro Arg Leu Ser Val Glu Ile Leu Leu Asp 
                405                 410                 415     


Arg Ile Thr Pro Tyr Leu Leu His Phe Ser Asn Asp Ser Val Pro Arg 
            420                 425                 430         


Val Arg Ala Glu Ala Leu Arg Thr Leu Thr Lys Val Leu Ala Leu Val 
        435                 440                 445             


Lys Glu Val Pro Arg Asn Asp Ile Asn Ile Tyr Pro Glu Tyr Ile Leu 
    450                 455                 460                 


Pro Gly Ile Ala His Leu Ala Gln Asp Asp Ala Thr Ile Val Arg Leu 
465                 470                 475                 480 


Ala Tyr Ala Glu Asn Ile Ala Leu Leu Ala Glu Thr Ala Leu Arg Phe 
                485                 490                 495     


Leu Glu Leu Val Gln Leu Lys Asn Leu Asn Met Glu Asn Asp Pro Asn 
            500                 505                 510         


Asn Glu Glu Ile Asp Glu Val Thr His Pro Asn Gly Asn Tyr Asp Thr 
        515                 520                 525             


Glu Leu Gln Ala Leu His Glu Met Val Gln Gln Lys Val Val Thr Leu 
    530                 535                 540                 


Leu Ser Asp Pro Glu Asn Ile Val Lys Gln Thr Leu Met Glu Asn Gly 
545                 550                 555                 560 


Ile Thr Arg Leu Cys Val Phe Phe Gly Arg Gln Lys Ala Asn Asp Val 
                565                 570                 575     


Leu Leu Ser His Met Ile Thr Phe Leu Asn Asp Lys Asn Asp Trp His 
            580                 585                 590         


Leu Arg Gly Ala Phe Phe Asp Ser Ile Val Gly Val Ala Ala Tyr Val 
        595                 600                 605             


Gly Trp Gln Ser Ser Ser Ile Leu Lys Pro Leu Leu Gln Gln Gly Leu 
    610                 615                 620                 


Ser Asp Ala Glu Glu Phe Val Ile Val Lys Ala Leu Tyr Ala Leu Thr 
625                 630                 635                 640 


Cys Met Cys Gln Leu Gly Leu Leu Gln Lys Pro His Val Tyr Glu Phe 
                645                 650                 655     


Ala Ser Asp Ile Ala Pro Phe Leu Cys His Pro Asn Leu Trp Ile Arg 
            660                 665                 670         


Tyr Gly Ala Val Gly Phe Ile Thr Val Val Ala Arg Gln Ile Ser Thr 
        675                 680                 685             


Ala Asp Val Tyr Cys Lys Leu Met Pro Tyr Leu Asp Pro Tyr Ile Thr 
    690                 695                 700                 


Gln Pro Ile Ile Gln Ile Glu Arg Lys Leu Val Leu Leu Ser Val Leu 
705                 710                 715                 720 


Lys Glu Pro Val Ser Arg Ser Ile Phe Asp Tyr Ala Leu Arg Ser Lys 
                725                 730                 735     


Asp Ile Thr Ser Leu Phe Arg His Leu His Met Arg Gln Lys Lys Arg 
            740                 745                 750         


Asn Gly Ser Leu Pro Asp Cys Pro Pro Pro Glu Asp Pro Ala Ile Ala 
        755                 760                 765             


Gln Leu Leu Lys Lys Leu Leu Ser Gln Gly Met Thr Glu Glu Glu Glu 
    770                 775                 780                 


Asp Lys Leu Leu Ala Leu Lys Asp Phe Met Met Lys Ser Asn Lys Ala 
785                 790                 795                 800 


Lys Ala Asn Ile Val Asp Gln Ser His Leu His Asp Ser Ser Gln Lys 
                805                 810                 815     


Gly Val Ile Asp Leu Ala Ala Leu Gly Ile Thr Gly Arg Gln Val Asp 
            820                 825                 830         


Leu Val Lys Thr Lys Gln Glu Pro Asp Asp Lys Arg Ala Arg Lys His 
        835                 840                 845             


Val Lys Gln Asp Ser Asn Val Asn Glu Glu Trp Lys Ser Met Phe Gly 
    850                 855                 860                 


Ser Leu Asp Pro Pro Asn Met Pro Gln Ala Leu Pro Lys Gly Ser Asp 
865                 870                 875                 880 


Gln Glu Val Ile Gln Thr Gly Lys Pro Pro Arg Ser Glu Ser Ser Ala 
                885                 890                 895     


Gly Ile Cys Val Pro Leu Ser Thr Ser Ser Gln Val Pro Glu Val Thr 
            900                 905                 910         


Thr Val Gln Asn Lys Lys Pro Val Ile Pro Val Leu Ser Ser Thr Ile 
        915                 920                 925             


Leu Pro Ser Thr Tyr Gln Ile Arg Ile Thr Thr Cys Lys Thr Glu Leu 
    930                 935                 940                 


Gln Gln Leu Ile Gln Gln Lys Arg Glu Gln Cys Asn Ala Glu Arg Ile 
945                 950                 955                 960 


Ala Lys Gln Met Met Glu Asn Ala Glu Trp Glu Ser Lys Pro Pro Pro 
                965                 970                 975     


Pro Gly Trp Arg Pro Lys Gly Leu Leu Val Ala His Leu His Glu His 
            980                 985                 990         


Lys Ser Ala Val Asn Arg Ile Arg  Val Ser Asp Glu His  Ser Leu Phe 
        995                 1000                 1005             


Ala Thr  Cys Ser Asn Asp Gly  Thr Val Lys Ile Trp  Asn Ser Gln 
    1010                 1015                 1020             


Lys Met  Glu Gly Lys Thr Thr  Thr Thr Arg Ser Ile  Leu Thr Tyr 
    1025                 1030                 1035             


Ser Arg  Ile Gly Gly Arg Val  Lys Thr Leu Thr Phe  Cys Gln Gly 
    1040                 1045                 1050             


Ser His  Tyr Leu Ala Ile Ala  Ser Asp Asn Gly Ala  Val Gln Leu 
    1055                 1060                 1065             


Leu Gly  Ile Glu Ala Ser Lys  Leu Pro Lys Ser Pro  Lys Ile His 
    1070                 1075                 1080             


Pro Leu  Gln Ser Arg Ile Leu  Asp Gln Lys Glu Asp  Gly Cys Val 
    1085                 1090                 1095             


Val Asp  Met His His Phe Asn  Ser Gly Ala Gln Ser  Val Leu Ala 
    1100                 1105                 1110             


Tyr Ala  Thr Val Asn Gly Ser  Leu Val Gly Trp Asp  Leu Arg Ser 
    1115                 1120                 1125             


Ser Ser  Asn Ala Trp Thr Leu  Lys His Asp Leu Lys  Ser Gly Leu 
    1130                 1135                 1140             


Ile Thr  Ser Phe Ala Val Asp  Ile His Gln Cys Trp  Leu Cys Ile 
    1145                 1150                 1155             


Gly Thr  Ser Ser Gly Thr Met  Ala Cys Trp Asp Met  Arg Phe Gln 
    1160                 1165                 1170             


Leu Pro  Ile Ser Ser His Cys  His Pro Ser Arg Ala  Arg Ile Arg 
    1175                 1180                 1185             


Arg Leu  Ser Met His Pro Leu  Tyr Gln Ser Trp Val  Ile Ala Ala 
    1190                 1195                 1200             


Val Gln  Gly Asn Asn Glu Val  Ser Met Trp Asp Met  Glu Thr Gly 
    1205                 1210                 1215             


Asp Arg  Arg Phe Thr Leu Trp  Ala Ser Ser Ala Pro  Pro Leu Ser 
    1220                 1225                 1230             


Glu Leu  Gln Pro Ser Pro His  Ser Val His Gly Ile  Tyr Cys Ser 
    1235                 1240                 1245             


Pro Ala  Asp Gly Asn Pro Ile  Leu Leu Thr Ala Gly  Ser Asp Met 
    1250                 1255                 1260             


Lys Ile  Arg Phe Trp Asp Leu  Ala Tyr Pro Glu Arg  Ser Tyr Val 
    1265                 1270                 1275             


Val Ala  Gly Ser Thr Ser Ser  Pro Ser Val Ser Tyr  Tyr Arg Lys 
    1280                 1285                 1290             


Ile Ile  Glu Gly Thr Glu Val  Val Gln Glu Ile Gln  Asn Lys Gln 
    1295                 1300                 1305             


Lys Val  Gly Pro Ser Asp Asp  Thr Pro Arg Arg Gly  Pro Glu Ser 
    1310                 1315                 1320             


Leu Pro  Val Gly His His Asp  Ile Ile Thr Asp Val  Ala Thr Phe 
    1325                 1330                 1335             


Gln Thr  Thr Gln Gly Phe Ile  Val Thr Ala Ser Arg  Asp Gly Ile 
    1340                 1345                 1350             


Val Lys  Val Trp Lys 
    1355             


<210>  69
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Leu Leu Ser Lys Phe Gly Ser Leu Ala His Leu Cys Gly Pro Gly 
1               5                   10                  15      


Gly Val Asp His Leu Pro Val Lys Ile Leu Gln Pro Ala Lys Ala Asp 
            20                  25                  30          


Lys Glu Ser Phe Glu Lys Ala Tyr Gln Val Gly Ala Val Leu Gly Ser 
        35                  40                  45              


Gly Gly Phe Gly Thr Val Tyr Ala Gly Ser Arg Ile Ala Asp Gly Leu 
    50                  55                  60                  


Pro Val Ala Val Lys His Val Val Lys Glu Arg Val Thr Glu Trp Gly 
65                  70                  75                  80  


Ser Leu Gly Gly Ala Thr Val Pro Leu Glu Val Val Leu Leu Arg Lys 
                85                  90                  95      


Val Gly Ala Ala Gly Gly Ala Arg Gly Val Ile Arg Leu Leu Asp Trp 
            100                 105                 110         


Phe Glu Arg Pro Asp Gly Phe Leu Leu Val Leu Glu Arg Pro Glu Pro 
        115                 120                 125             


Ala Gln Asp Leu Phe Asp Phe Ile Thr Glu Arg Gly Ala Leu Asp Glu 
    130                 135                 140                 


Pro Leu Ala Arg Arg Phe Phe Ala Gln Val Leu Ala Ala Val Arg His 
145                 150                 155                 160 


Cys His Ser Cys Gly Val Val His Arg Asp Ile Lys Asp Glu Asn Leu 
                165                 170                 175     


Leu Val Asp Leu Arg Ser Gly Glu Leu Lys Leu Ile Asp Phe Gly Ser 
            180                 185                 190         


Gly Ala Leu Leu Lys Asp Thr Val Tyr Thr Asp Phe Asp Gly Thr Arg 
        195                 200                 205             


Val Tyr Ser Pro Pro Glu Trp Ile Arg Tyr His Arg Tyr His Gly Arg 
    210                 215                 220                 


Ser Ala Thr Val Trp Ser Leu Gly Val Leu Leu Tyr Asp Met Val Cys 
225                 230                 235                 240 


Gly Asp Ile Pro Phe Glu Gln Asp Glu Glu Ile Leu Arg Gly Arg Leu 
                245                 250                 255     


Leu Phe Arg Arg Arg Val Ser Pro Glu Cys Gln Gln Leu Ile Arg Trp 
            260                 265                 270         


Cys Leu Ser Leu Arg Pro Ser Glu Arg Pro Ser Leu Asp Gln Ile Ala 
        275                 280                 285             


Ala His Pro Trp Met Leu Gly Ala Asp Gly Gly Val Pro Glu Ser Cys 
    290                 295                 300                 


Asp Leu Arg Leu Cys Thr Leu Asp Pro Asp Asp Val Ala Ser Thr Thr 
305                 310                 315                 320 


Ser Ser Ser Glu Ser Leu 
                325     


<210>  70
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Val Pro Pro Lys Leu His Val Leu Phe Cys Leu Cys Gly Cys Leu 
1               5                   10                  15      


Ala Val Val Tyr Pro Phe Asp Trp Gln Tyr Ile Asn Pro Val Ala His 
            20                  25                  30          


Met Lys Ser Ser Ala Trp Val Asn Lys Ile Gln Val Leu Met Ala Ala 
        35                  40                  45              


Ala Ser Phe Gly Gln Thr Lys Ile Pro Arg Gly Asn Gly Pro Tyr Ser 
    50                  55                  60                  


Val Gly Cys Thr Asp Leu Met Phe Asp His Thr Asn Lys Gly Thr Phe 
65                  70                  75                  80  


Leu Arg Leu Tyr Tyr Pro Ser Gln Asp Asn Asp Arg Leu Asp Thr Leu 
                85                  90                  95      


Trp Ile Pro Asn Lys Glu Tyr Phe Trp Gly Leu Ser Lys Phe Leu Gly 
            100                 105                 110         


Thr His Trp Leu Met Gly Asn Ile Leu Arg Leu Leu Phe Gly Ser Met 
        115                 120                 125             


Thr Thr Pro Ala Asn Trp Asn Ser Pro Leu Arg Pro Gly Glu Lys Tyr 
    130                 135                 140                 


Pro Leu Val Val Phe Ser His Gly Leu Gly Ala Phe Arg Thr Leu Tyr 
145                 150                 155                 160 


Ser Ala Ile Gly Ile Asp Leu Ala Ser His Gly Phe Ile Val Ala Ala 
                165                 170                 175     


Val Glu His Arg Asp Arg Ser Ala Ser Ala Thr Tyr Tyr Phe Lys Asp 
            180                 185                 190         


Gln Ser Ala Ala Glu Ile Gly Asp Lys Ser Trp Leu Tyr Leu Arg Thr 
        195                 200                 205             


Leu Lys Gln Glu Glu Glu Thr His Ile Arg Asn Glu Gln Val Arg Gln 
    210                 215                 220                 


Arg Ala Lys Glu Cys Ser Gln Ala Leu Ser Leu Ile Leu Asp Ile Asp 
225                 230                 235                 240 


His Gly Lys Pro Val Lys Asn Ala Leu Asp Leu Lys Phe Asp Met Glu 
                245                 250                 255     


Gln Leu Lys Asp Ser Ile Asp Arg Glu Lys Ile Ala Val Ile Gly His 
            260                 265                 270         


Ser Phe Gly Gly Ala Thr Val Ile Gln Thr Leu Ser Glu Asp Gln Arg 
        275                 280                 285             


Phe Arg Cys Gly Ile Ala Leu Asp Ala Trp Met Phe Pro Leu Gly Asp 
    290                 295                 300                 


Glu Val Tyr Ser Arg Ile Pro Gln Pro Leu Phe Phe Ile Asn Ser Glu 
305                 310                 315                 320 


Tyr Phe Gln Tyr Pro Ala Asn Ile Ile Lys Met Lys Lys Cys Tyr Ser 
                325                 330                 335     


Pro Asp Lys Glu Arg Lys Met Ile Thr Ile Arg Gly Ser Val His Gln 
            340                 345                 350         


Asn Phe Ala Asp Phe Thr Phe Ala Thr Gly Lys Ile Ile Gly His Met 
        355                 360                 365             


Leu Lys Leu Lys Gly Asp Ile Asp Ser Asn Val Ala Ile Asp Leu Ser 
    370                 375                 380                 


Asn Lys Ala Ser Leu Ala Phe Leu Gln Lys His Leu Gly Leu His Lys 
385                 390                 395                 400 


Asp Phe Asp Gln Trp Asp Cys Leu Ile Glu Gly Asp Asp Glu Asn Leu 
                405                 410                 415     


Ile Pro Gly Thr Asn Ile Asn Thr Thr Asn Gln His Ile Met Leu Gln 
            420                 425                 430         


Asn Ser Ser Gly Ile Glu Lys Tyr Asn 
        435                 440     


<210>  71
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala 
1               5                   10                  15      


Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly 
            20                  25                  30          


Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser 
        35                  40                  45              


Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp 
    50                  55                  60                  


Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly 
                85                  90                  95      


Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr 
            100                 105                 110         


His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg 
        115                 120                 125             


Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe His Lys 
145                 150                 155                 160 


Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met 
                165                 170                 175     


Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu 
            180                 185                 190         


His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys 
        195                 200                 205             


Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys 
    210                 215                 220                 


Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val 
225                 230                 235                 240 


Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala 
                245                 250                 255     


Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile 
            260                 265                 270         


Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr 
        275                 280                 285             


Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp 
    290                 295                 300                 


Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met 
305                 310                 315                 320 


Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn 
                325                 330                 335     


Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys 
            340                 345                 350         


Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu 
        355                 360                 365             


Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys 
    370                 375                 380                 


Cys Gly Asp Arg Pro Gly Leu Leu Asn Val Gly His Ile Glu Lys Met 
385                 390                 395                 400 


Gln Glu Gly Ile Val His Val Leu Arg Leu His Leu Gln Ser Asn His 
                405                 410                 415     


Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp 
            420                 425                 430         


Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val Gln Ile Ile Lys 
        435                 440                 445             


Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu Gln Glu Ile Tyr 
    450                 455                 460                 


Arg Asp Met Tyr 
465             


<210>  72
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu 
1               5                   10                  15      


Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile 
            20                  25                  30          


Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg 
        35                  40                  45              


Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu 
    50                  55                  60                  


Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val 
65                  70                  75                  80  


Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu 
                85                  90                  95      


Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu 
            100                 105                 110         


Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe 
        115                 120                 125             


Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg 
    130                 135                 140                 


Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser 
145                 150                 155                 160 


Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp 
                165                 170                 175     


Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe 
            180                 185                 190         


Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met 
        195                 200                 205             


Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala 
    210                 215                 220                 


Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu 
225                 230                 235                 240 


Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser 
                245                 250                 255     


Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys 
            260                 265                 270         


Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln 
        275                 280                 285             


Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His 
    290                 295                 300                 


Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn 
305                 310                 315                 320 


Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp 
                325                 330                 335     


Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu 
            340                 345                 350         


Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu 
        355                 360                 365             


Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile 
    370                 375                 380                 


Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu 
385                 390                 395                 400 


Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys 
                405                 410                 415     


Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly 
            420                 425                 430         


Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met 
        435                 440                 445             


Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser 
    450                 455                 460                 


Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala 
465                 470                 475                 480 


Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu 
                485                 490                 495     


His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys 
            500                 505                 510         


Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met 
        515                 520                 525             


Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu 
    530                 535                 540                 


Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val 
545                 550                 555                 560 


Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys 
                565                 570                 575     


Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala 
            580                 585                 


<210>  73
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  74
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Ala Met Ala Val Gly Gly Ala Gly Gly Ser Arg Val Ser Ser 
1               5                   10                  15      


Gly Arg Asp Leu Asn Cys Val Pro Glu Ile Ala Asp Thr Leu Gly Ala 
            20                  25                  30          


Val Ala Lys Gln Gly Phe Asp Phe Leu Cys Met Pro Val Phe His Pro 
        35                  40                  45              


Arg Phe Lys Arg Glu Phe Ile Gln Glu Pro Ala Lys Asn Arg Pro Gly 
    50                  55                  60                  


Pro Gln Thr Arg Ser Asp Leu Leu Leu Ser Gly Arg Asp Trp Asn Thr 
65                  70                  75                  80  


Leu Ile Val Gly Lys Leu Ser Pro Trp Ile Arg Pro Asp Ser Lys Val 
                85                  90                  95      


Glu Lys Ile Arg Arg Asn Ser Glu Ala Ala Met Leu Gln Glu Leu Asn 
            100                 105                 110         


Phe Gly Ala Tyr Leu Gly Leu Pro Ala Phe Leu Leu Pro Leu Asn Gln 
        115                 120                 125             


Glu Asp Asn Thr Asn Leu Ala Arg Val Leu Thr Asn His Ile His Thr 
    130                 135                 140                 


Gly His His Ser Ser Met Phe Trp Met Arg Val Pro Leu Val Ala Pro 
145                 150                 155                 160 


Glu Asp Leu Arg Asp Asp Ile Ile Glu Asn Ala Pro Thr Thr His Thr 
                165                 170                 175     


Glu Glu Tyr Ser Gly Glu Glu Lys Thr Trp Met Trp Trp His Asn Phe 
            180                 185                 190         


Arg Thr Leu Cys Asp Tyr Ser Lys Arg Ile Ala Val Ala Leu Glu Ile 
        195                 200                 205             


Gly Ala Asp Leu Pro Ser Asn His Val Ile Asp Arg Trp Leu Gly Glu 
    210                 215                 220                 


Pro Ile Lys Ala Ala Ile Leu Pro Thr Ser Ile Phe Leu Thr Asn Lys 
225                 230                 235                 240 


Lys Gly Phe Pro Val Leu Ser Lys Met His Gln Arg Leu Ile Phe Arg 
                245                 250                 255     


Leu Leu Lys Leu Glu Val Gln Phe Ile Ile Thr Gly Thr Asn His His 
            260                 265                 270         


Ser Glu Lys Glu Phe Cys Ser Tyr Leu Gln Tyr Leu Glu Tyr Leu Ser 
        275                 280                 285             


Gln Asn Arg Pro Pro Pro Asn Ala Tyr Glu Leu Phe Ala Lys Gly Tyr 
    290                 295                 300                 


Glu Asp Tyr Leu Gln Ser Pro Leu Gln Pro Leu Met Asp Asn Leu Glu 
305                 310                 315                 320 


Ser Gln Thr Tyr Glu Val Phe Glu Lys Asp Pro Ile Lys Tyr Ser Gln 
                325                 330                 335     


Tyr Gln Gln Ala Ile Tyr Lys Cys Leu Leu Asp Arg Val Pro Glu Glu 
            340                 345                 350         


Glu Lys Asp Thr Asn Val Gln Val Leu Met Val Leu Gly Ala Gly Arg 
        355                 360                 365             


Gly Pro Leu Val Asn Ala Ser Leu Arg Ala Ala Lys Gln Ala Asp Arg 
    370                 375                 380                 


Arg Ile Lys Leu Tyr Ala Val Glu Lys Asn Pro Asn Ala Val Val Thr 
385                 390                 395                 400 


Leu Glu Asn Trp Gln Phe Glu Glu Trp Gly Ser Gln Val Thr Val Val 
                405                 410                 415     


Ser Ser Asp Met Arg Glu Trp Val Ala Pro Glu Lys Ala Asp Ile Ile 
            420                 425                 430         


Val Ser Glu Leu Leu Gly Ser Phe Ala Asp Asn Glu Leu Ser Pro Glu 
        435                 440                 445             


Cys Leu Asp Gly Ala Gln His Phe Leu Lys Asp Asp Gly Val Ser Ile 
    450                 455                 460                 


Pro Gly Glu Tyr Thr Ser Phe Leu Ala Pro Ile Ser Ser Ser Lys Leu 
465                 470                 475                 480 


Tyr Asn Glu Val Arg Ala Cys Arg Glu Lys Asp Arg Asp Pro Glu Ala 
                485                 490                 495     


Gln Phe Glu Met Pro Tyr Val Val Arg Leu His Asn Phe His Gln Leu 
            500                 505                 510         


Ser Ala Pro Gln Pro Cys Phe Thr Phe Ser His Pro Asn Arg Asp Pro 
        515                 520                 525             


Met Ile Asp Asn Asn Arg Tyr Cys Thr Leu Glu Phe Pro Val Glu Val 
    530                 535                 540                 


Asn Thr Val Leu His Gly Phe Ala Gly Tyr Phe Glu Thr Val Leu Tyr 
545                 550                 555                 560 


Gln Asp Ile Thr Leu Ser Ile Arg Pro Glu Thr His Ser Pro Gly Met 
                565                 570                 575     


Phe Ser Trp Phe Pro Ile Leu Phe Pro Ile Lys Gln Pro Ile Thr Val 
            580                 585                 590         


Arg Glu Gly Gln Thr Ile Cys Val Arg Phe Trp Arg Cys Ser Asn Ser 
        595                 600                 605             


Lys Lys Val Trp Tyr Glu Trp Ala Val Thr Ala Pro Val Cys Ser Ala 
    610                 615                 620                 


Ile His Asn Pro Thr Gly Arg Ser Tyr Thr Ile Gly Leu 
625                 630                 635         


<210>  75
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Leu Ser Ser Thr Ala Met Tyr Ser Ala Pro Gly Arg Asp Leu Gly 
1               5                   10                  15      


Met Glu Pro His Arg Ala Ala Gly Pro Leu Gln Leu Arg Phe Ser Pro 
            20                  25                  30          


Tyr Val Phe Asn Gly Gly Thr Ile Leu Ala Ile Ala Gly Glu Asp Phe 
        35                  40                  45              


Ala Ile Val Ala Ser Asp Thr Arg Leu Ser Glu Gly Phe Ser Ile His 
    50                  55                  60                  


Thr Arg Asp Ser Pro Lys Cys Tyr Lys Leu Thr Asp Lys Thr Val Ile 
65                  70                  75                  80  


Gly Cys Ser Gly Phe His Gly Asp Cys Leu Thr Leu Thr Lys Ile Ile 
                85                  90                  95      


Glu Ala Arg Leu Lys Met Tyr Lys His Ser Asn Asn Lys Ala Met Thr 
            100                 105                 110         


Thr Gly Ala Ile Ala Ala Met Leu Ser Thr Ile Leu Tyr Ser Arg Arg 
        115                 120                 125             


Phe Phe Pro Tyr Tyr Val Tyr Asn Ile Ile Gly Gly Leu Asp Glu Glu 
    130                 135                 140                 


Gly Lys Gly Ala Val Tyr Ser Phe Asp Pro Val Gly Ser Tyr Gln Arg 
145                 150                 155                 160 


Asp Ser Phe Lys Ala Gly Gly Ser Ala Ser Ala Met Leu Gln Pro Leu 
                165                 170                 175     


Leu Asp Asn Gln Val Gly Phe Lys Asn Met Gln Asn Val Glu His Val 
            180                 185                 190         


Pro Leu Ser Leu Asp Arg Ala Met Arg Leu Val Lys Asp Val Phe Ile 
        195                 200                 205             


Ser Ala Ala Glu Arg Asp Val Tyr Thr Gly Asp Ala Leu Arg Ile Cys 
    210                 215                 220                 


Ile Val Thr Lys Glu Gly Ile Arg Glu Glu Thr Val Ser Leu Arg Lys 
225                 230                 235                 240 


Asp 
    


<210>  76
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro 
1               5                   10                  15      


Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met 
            20                  25                  30          


Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn 
        35                  40                  45              


Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly 
    50                  55                  60                  


Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg 
65                  70                  75                  80  


Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu 
                85                  90                  95      


Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu 
            100                 105                 110         


Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr 
        115                 120                 125             


Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg 
    130                 135                 140                 


Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr 
145                 150                 155                 160 


Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala 
                165                 170                 175     


Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln 
            180                 185                 190         


Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr 
        195                 200                 205             


Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg 
    210                 215                 220                 


Asp Ala Arg Ser Tyr Asn Arg Phe Gln Ile Ala Thr Val Thr Glu Lys 
225                 230                 235                 240 


Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile 
                245                 250                 255     


Ala His Met Ile Ser Gly Phe Glu 
            260                 


<210>  77
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ala Ala Thr Leu Leu Ala Ala Arg Gly Ala Gly Pro Ala Pro Ala 
1               5                   10                  15      


Trp Gly Pro Glu Ala Phe Thr Pro Asp Trp Glu Ser Arg Glu Val Ser 
            20                  25                  30          


Thr Gly Thr Thr Ile Met Ala Val Gln Phe Asp Gly Gly Val Val Leu 
        35                  40                  45              


Gly Ala Asp Ser Arg Thr Thr Thr Gly Ser Tyr Ile Ala Asn Arg Val 
    50                  55                  60                  


Thr Asp Lys Leu Thr Pro Ile His Asp Arg Ile Phe Cys Cys Arg Ser 
65                  70                  75                  80  


Gly Ser Ala Ala Asp Thr Gln Ala Val Ala Asp Ala Val Thr Tyr Gln 
                85                  90                  95      


Leu Gly Phe His Ser Ile Glu Leu Asn Glu Pro Pro Leu Val His Thr 
            100                 105                 110         


Ala Ala Ser Leu Phe Lys Glu Met Cys Tyr Arg Tyr Arg Glu Asp Leu 
        115                 120                 125             


Met Ala Gly Ile Ile Ile Ala Gly Trp Asp Pro Gln Glu Gly Gly Gln 
    130                 135                 140                 


Val Tyr Ser Val Pro Met Gly Gly Met Met Val Arg Gln Ser Phe Ala 
145                 150                 155                 160 


Ile Gly Gly Ser Gly Ser Ser Tyr Ile Tyr Gly Tyr Val Asp Ala Thr 
                165                 170                 175     


Tyr Arg Glu Gly Met Thr Lys Glu Glu Cys Leu Gln Phe Thr Ala Asn 
            180                 185                 190         


Ala Leu Ala Leu Ala Met Glu Arg Asp Gly Ser Ser Gly Gly Val Ile 
        195                 200                 205             


Arg Leu Ala Ala Ile Ala Glu Ser Gly Val Glu Arg Gln Val Leu Leu 
    210                 215                 220                 


Gly Asp Gln Ile Pro Lys Phe Ala Val Ala Thr Leu Pro Pro Ala 
225                 230                 235                 


<210>  78
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ala Ala Val Ser Val Tyr Ala Pro Pro Val Gly Gly Phe Ser Phe 
1               5                   10                  15      


Asp Asn Cys Arg Arg Asn Ala Val Leu Glu Ala Asp Phe Ala Lys Arg 
            20                  25                  30          


Gly Tyr Lys Leu Pro Lys Val Arg Lys Thr Gly Thr Thr Ile Ala Gly 
        35                  40                  45              


Val Val Tyr Lys Asp Gly Ile Val Leu Gly Ala Asp Thr Arg Ala Thr 
    50                  55                  60                  


Glu Gly Met Val Val Ala Asp Lys Asn Cys Ser Lys Ile His Phe Ile 
65                  70                  75                  80  


Ser Pro Asn Ile Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Asp 
                85                  90                  95      


Met Thr Thr Gln Leu Ile Ser Ser Asn Leu Glu Leu His Ser Leu Ser 
            100                 105                 110         


Thr Gly Arg Leu Pro Arg Val Val Thr Ala Asn Arg Met Leu Lys Gln 
        115                 120                 125             


Met Leu Phe Arg Tyr Gln Gly Tyr Ile Gly Ala Ala Leu Val Leu Gly 
    130                 135                 140                 


Gly Val Asp Val Thr Gly Pro His Leu Tyr Ser Ile Tyr Pro His Gly 
145                 150                 155                 160 


Ser Thr Asp Lys Leu Pro Tyr Val Thr Met Gly Ser Gly Ser Leu Ala 
                165                 170                 175     


Ala Met Ala Val Phe Glu Asp Lys Phe Arg Pro Asp Met Glu Glu Glu 
            180                 185                 190         


Glu Ala Lys Asn Leu Val Ser Glu Ala Ile Ala Ala Gly Ile Phe Asn 
        195                 200                 205             


Asp Leu Gly Ser Gly Ser Asn Ile Asp Leu Cys Val Ile Ser Lys Asn 
    210                 215                 220                 


Lys Leu Asp Phe Leu Arg Pro Tyr Thr Val Pro Asn Lys Lys Gly Thr 
225                 230                 235                 240 


Arg Leu Gly Arg Tyr Arg Cys Glu Lys Gly Thr Thr Ala Val Leu Thr 
                245                 250                 255     


Glu Lys Ile Thr Pro Leu Glu Ile Glu Val Leu Glu Glu Thr Val Gln 
            260                 265                 270         


Thr Met Asp Thr Ser 
        275         


<210>  79
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Asp Ala Ala Val Asp Thr Ser Ser Glu Ile Thr Thr Lys Asp 
1               5                   10                  15      


Leu Lys Glu Lys Lys Glu Val Val Glu Glu Ala Glu Asn Gly Arg Asp 
            20                  25                  30          


Ala Pro Ala Asn Gly Asn Ala Glu Asn Glu Glu Asn Gly Glu Gln Glu 
        35                  40                  45              


Ala Asp Asn Glu Val Asp Glu Glu Glu Glu Glu Gly Gly Glu Glu Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Asp Gly Glu Glu Glu Asp Gly Asp Glu Asp 
65                  70                  75                  80  


Glu Glu Ala Glu Ser Ala Thr Gly Lys Arg Ala Ala Glu Asp Asp Glu 
                85                  90                  95      


Asp Asp Asp Val Asp Thr Lys Lys Gln Lys Thr Asp Glu Asp Asp 
            100                 105                 110     


<210>  80
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Glu Met Glu Lys Glu Phe Glu Gln Ile Asp Lys Ser Gly Ser Trp 
1               5                   10                  15      


Ala Ala Ile Tyr Gln Asp Ile Arg His Glu Ala Ser Asp Phe Pro Cys 
            20                  25                  30          


Arg Val Ala Lys Leu Pro Lys Asn Lys Asn Arg Asn Arg Tyr Arg Asp 
        35                  40                  45              


Val Ser Pro Phe Asp His Ser Arg Ile Lys Leu His Gln Glu Asp Asn 
    50                  55                  60                  


Asp Tyr Ile Asn Ala Ser Leu Ile Lys Met Glu Glu Ala Gln Arg Ser 
65                  70                  75                  80  


Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Gly His Phe Trp 
                85                  90                  95      


Glu Met Val Trp Glu Gln Lys Ser Arg Gly Val Val Met Leu Asn Arg 
            100                 105                 110         


Val Met Glu Lys Gly Ser Leu Lys Cys Ala Gln Tyr Trp Pro Gln Lys 
        115                 120                 125             


Glu Glu Lys Glu Met Ile Phe Glu Asp Thr Asn Leu Lys Leu Thr Leu 
    130                 135                 140                 


Ile Ser Glu Asp Ile Lys Ser Tyr Tyr Thr Val Arg Gln Leu Glu Leu 
145                 150                 155                 160 


Glu Asn Leu Thr Thr Gln Glu Thr Arg Glu Ile Leu His Phe His Tyr 
                165                 170                 175     


Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe Leu 
            180                 185                 190         


Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Ser Pro Glu His 
        195                 200                 205             


Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Ser Gly Thr 
    210                 215                 220                 


Phe Cys Leu Ala Asp Thr Cys Leu Leu Leu Met Asp Lys Arg Lys Asp 
225                 230                 235                 240 


Pro Ser Ser Val Asp Ile Lys Lys Val Leu Leu Glu Met Arg Lys Phe 
                245                 250                 255     


Arg Met Gly Leu Ile Gln Thr Ala Asp Gln Leu Arg Phe Ser Tyr Leu 
            260                 265                 270         


Ala Val Ile Glu Gly Ala Lys Phe Ile Met Gly Asp Ser Ser Val Gln 
        275                 280                 285             


Asp Gln Trp Lys Glu Leu Ser His Glu Asp Leu Glu Pro Pro Pro Glu 
    290                 295                 300                 


His Ile Pro Pro Pro Pro Arg Pro Pro Lys Arg Ile Leu Glu Pro His 
305                 310                 315                 320 


Asn Gly Lys Cys Arg Glu Phe Phe Pro Asn His Gln Trp Val Lys Glu 
                325                 330                 335     


Glu Thr Gln Glu Asp Lys Asp Cys Pro Ile Lys Glu Glu Lys Gly Ser 
            340                 345                 350         


Pro Leu Asn Ala Ala Pro Tyr Gly Ile Glu Ser Met Ser Gln Asp Thr 
        355                 360                 365             


Glu Val Arg Ser Arg Val Val Gly Gly Ser Leu Arg Gly Ala Gln Ala 
    370                 375                 380                 


Ala Ser Pro Ala Lys Gly Glu Pro Ser Leu Pro Glu Lys Asp Glu Asp 
385                 390                 395                 400 


His Ala Leu Ser Tyr Trp Lys Pro Phe Leu Val Asn Met Cys Val Ala 
                405                 410                 415     


Thr Val Leu Thr Ala Gly Ala Tyr Leu Cys Tyr Arg Phe Leu Phe Asn 
            420                 425                 430         


Ser Asn Thr 
        435 


<210>  81
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  82
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ala Glu Val Gln Val Leu Val Leu Asp Gly Arg Gly His Leu Leu 
1               5                   10                  15      


Gly Arg Leu Ala Ala Ile Val Ala Lys Gln Val Leu Leu Gly Arg Lys 
            20                  25                  30          


Val Val Val Val Arg Cys Glu Gly Ile Asn Ile Ser Gly Asn Phe Tyr 
        35                  40                  45              


Arg Asn Lys Leu Lys Tyr Leu Ala Phe Leu Arg Lys Arg Met Asn Thr 
    50                  55                  60                  


Asn Pro Ser Arg Gly Pro Tyr His Phe Arg Ala Pro Ser Arg Ile Phe 
65                  70                  75                  80  


Trp Arg Thr Val Arg Gly Met Leu Pro His Lys Thr Lys Arg Gly Gln 
                85                  90                  95      


Ala Ala Leu Asp Arg Leu Lys Val Phe Asp Gly Ile Pro Pro Pro Tyr 
            100                 105                 110         


Asp Lys Lys Lys Arg Met Val Val Pro Ala Ala Leu Lys Val Val Arg 
        115                 120                 125             


Leu Lys Pro Thr Arg Lys Phe Ala Tyr Leu Gly Arg Leu Ala His Glu 
    130                 135                 140                 


Val Gly Trp Lys Tyr Gln Ala Val Thr Ala Thr Leu Glu Glu Lys Arg 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Ile His Tyr Arg Lys Lys Lys Gln Leu Met Arg 
                165                 170                 175     


Leu Arg Lys Gln Ala Glu Lys Asn Val Glu Lys Lys Ile Asp Lys Tyr 
            180                 185                 190         


Thr Glu Val Leu Lys Thr His Gly Leu Leu Val 
        195                 200             


<210>  83
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15      


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30          


Pro Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45              


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60                  


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80  


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95      


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110         


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125             


Ala Phe Thr Lys Tyr Cys Lys Lys Trp Gln Asp Glu Asp Gly Lys Lys 
    130                 135                 140                 


Gln Leu Glu Lys Asp Phe Ser Ser Met Lys Lys Tyr Cys Gln Val Ile 
145                 150                 155                 160 


Arg Val Ile Ala His Thr Gln Met Arg Leu Leu Pro Leu Arg Gln Lys 
                165                 170                 175     


Lys Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu 
            180                 185                 190         


Lys Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn 
        195                 200                 205             


Gln Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys 
    210                 215                 220                 


Gly Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu 
225                 230                 235                 240 


Pro Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala 
                245                 250                 255     


Trp His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys 
            260                 265                 270         


Gly Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly 
        275                 280                 285             


Gln Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser 
    290                 295                 300                 


Thr Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe 
305                 310                 315                 320 


Val His Tyr Gly Glu Val Thr Asn Asp Phe Val Met Leu Lys Gly Cys 
                325                 330                 335     


Val Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu 
            340                 345                 350         


Val Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile 
        355                 360                 365             


Asp Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu 
    370                 375                 380                 


Lys Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Ala 
            


<210>  84
<211>  1335
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu 
1               5                   10                  15      


Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys 
            20                  25                  30          


Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser 
        35                  40                  45              


Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu 
    50                  55                  60                  


Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro 
65                  70                  75                  80  


Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln 
                85                  90                  95      


Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn 
            100                 105                 110         


Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp 
        115                 120                 125             


Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu 
    130                 135                 140                 


Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val 
145                 150                 155                 160 


Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro 
                165                 170                 175     


Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe 
            180                 185                 190         


Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln 
        195                 200                 205             


Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro 
    210                 215                 220                 


Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys 
225                 230                 235                 240 


Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro 
                245                 250                 255     


Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys 
            260                 265                 270         


Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro 
        275                 280                 285             


Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp 
    290                 295                 300                 


Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr 
305                 310                 315                 320 


Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu 
                325                 330                 335     


Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu 
            340                 345                 350         


Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro 
        355                 360                 365             


Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu 
    370                 375                 380                 


Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly 
385                 390                 395                 400 


Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe 
                405                 410                 415     


Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln 
            420                 425                 430         


Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg 
        435                 440                 445             


Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val 
    450                 455                 460                 


Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala 
                485                 490                 495     


Lys Ile Leu Ala Val Asp Ser Ser Cys Gln Ala Asp Leu Val Lys Asp 
            500                 505                 510         


Asn Gly His Lys Tyr Phe Leu Ser Val Leu Ala Asp Pro Tyr Met Pro 
        515                 520                 525             


Ala Glu His Arg Thr Met Thr Ala Phe Ile Leu Ala Val Ile Val Asn 
    530                 535                 540                 


Ser Tyr His Thr Gly Gln Glu Ala Cys Leu Gln Gly Asn Leu Ile Ala 
545                 550                 555                 560 


Ile Cys Leu Glu Gln Leu Asn Asp Pro His Pro Leu Leu Arg Gln Trp 
                565                 570                 575     


Val Ala Ile Cys Leu Gly Arg Ile Trp Gln Asn Phe Asp Ser Ala Arg 
            580                 585                 590         


Trp Cys Gly Val Arg Asp Ser Ala His Glu Lys Leu Tyr Ser Leu Leu 
        595                 600                 605             


Ser Asp Pro Ile Pro Glu Val Arg Cys Ala Ala Val Phe Ala Leu Gly 
    610                 615                 620                 


Thr Phe Val Gly Asn Ser Ala Glu Arg Thr Asp His Ser Thr Thr Ile 
625                 630                 635                 640 


Asp His Asn Val Ala Met Met Leu Ala Gln Leu Val Ser Asp Gly Ser 
                645                 650                 655     


Pro Met Val Arg Lys Glu Leu Val Val Ala Leu Ser His Leu Val Val 
            660                 665                 670         


Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile Glu Glu 
        675                 680                 685             


Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly Gly Ser 
    690                 695                 700                 


Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg Ser Val 
705                 710                 715                 720 


Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser Leu Asn 
                725                 730                 735     


Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly Ala Val 
            740                 745                 750         


Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser Ser Thr 
        755                 760                 765             


Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu Thr Ile 
    770                 775                 780                 


Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser Leu Ile 
785                 790                 795                 800 


Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val Leu Leu 
                805                 810                 815     


His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala Met Lys 
            820                 825                 830         


Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg Pro Gln 
        835                 840                 845             


Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala Ser Pro 
    850                 855                 860                 


Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro Pro Ala 
865                 870                 875                 880 


Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys Gln Pro 
                885                 890                 895     


Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly Pro Ala 
            900                 905                 910         


Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr Arg Lys 
        915                 920                 925             


Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp Asp Ala 
    930                 935                 940                 


Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly Phe Cys 
945                 950                 955                 960 


Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile Pro Glu 
                965                 970                 975     


Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp Arg Phe 
            980                 985                 990         


Leu Arg Asn Ser Arg Val Arg Arg  Gln Ala Gln Gln Val  Ile Gln Lys 
        995                 1000                 1005             


Gly Ile  Thr Arg Leu Asp Asp  Gln Ile Phe Leu Asn  Arg Asn Pro 
    1010                 1015                 1020             


Gly Val  Pro Ser Val Val Lys  Phe His Pro Phe Thr  Pro Cys Ile 
    1025                 1030                 1035             


Ala Val  Ala Asp Lys Asp Ser  Ile Cys Phe Trp Asp  Trp Glu Lys 
    1040                 1045                 1050             


Gly Glu  Lys Leu Asp Tyr Phe  His Asn Gly Asn Pro  Arg Tyr Thr 
    1055                 1060                 1065             


Arg Val  Thr Ala Met Glu Tyr  Leu Asn Gly Gln Asp  Cys Ser Leu 
    1070                 1075                 1080             


Leu Leu  Thr Ala Thr Asp Asp  Gly Ala Ile Arg Val  Trp Lys Asn 
    1085                 1090                 1095             


Phe Ala  Asp Leu Glu Lys Asn  Pro Glu Met Val Thr  Ala Trp Gln 
    1100                 1105                 1110             


Gly Leu  Ser Asp Met Leu Pro  Thr Thr Arg Gly Ala  Gly Met Val 
    1115                 1120                 1125             


Val Asp  Trp Glu Gln Glu Thr  Gly Leu Leu Met Ser  Ser Gly Asp 
    1130                 1135                 1140             


Val Arg  Ile Val Arg Ile Trp  Asp Thr Asp Arg Glu  Met Lys Val 
    1145                 1150                 1155             


Gln Asp  Ile Pro Thr Gly Ala  Asp Ser Cys Val Thr  Ser Leu Ser 
    1160                 1165                 1170             


Cys Asp  Ser His Arg Ser Leu  Ile Val Ala Gly Leu  Gly Asp Gly 
    1175                 1180                 1185             


Ser Ile  Arg Val Tyr Asp Arg  Arg Met Ala Leu Ser  Glu Cys Arg 
    1190                 1195                 1200             


Val Met  Thr Tyr Arg Glu His  Thr Ala Trp Val Val  Lys Ala Ser 
    1205                 1210                 1215             


Leu Gln  Lys Arg Pro Asp Gly  His Ile Val Ser Val  Ser Val Asn 
    1220                 1225                 1230             


Gly Asp  Val Arg Ile Phe Asp  Pro Arg Met Pro Glu  Ser Val Asn 
    1235                 1240                 1245             


Val Leu  Gln Ile Val Lys Gly  Leu Thr Ala Leu Asp  Ile His Pro 
    1250                 1255                 1260             


Gln Ala  Asp Leu Ile Ala Cys  Gly Ser Val Asn Gln  Phe Thr Ala 
    1265                 1270                 1275             


Ile Tyr  Asn Ser Ser Gly Glu  Leu Ile Asn Asn Ile  Lys Tyr Tyr 
    1280                 1285                 1290             


Asp Gly  Phe Met Gly Gln Arg  Val Gly Ala Ile Ser  Cys Leu Ala 
    1295                 1300                 1305             


Phe His  Pro His Trp Pro His  Leu Ala Val Gly Ser  Asn Asp Tyr 
    1310                 1315                 1320             


Tyr Ile  Ser Val Tyr Ser Val  Glu Lys Arg Val Arg  
    1325                 1330                 1335 


<210>  85
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  85

Met His Val Ile Lys Arg Asp Gly Arg Gln Glu Arg Val Met Phe Asp 
1               5                   10                  15      


Lys Ile Thr Ser Arg Ile Gln Lys Leu Cys Tyr Gly Leu Asn Met Asp 
            20                  25                  30          


Phe Val Asp Pro Ala Gln Ile Thr Met Lys Val Ile Gln Gly Leu Tyr 
        35                  40                  45              


Ser Gly Val Thr Thr Val Glu Leu Asp Thr Leu Ala Ala Glu Thr Ala 
    50                  55                  60                  


Ala Thr Leu Thr Thr Lys His Pro Asp Tyr Ala Ile Leu Ala Ala Arg 
65                  70                  75                  80  


Ile Ala Val Ser Asn Leu His Lys Glu Thr Lys Lys Val Phe Ser Asp 
                85                  90                  95      


Val Met Glu Asp Leu Tyr Asn Tyr Ile Asn Pro His Asn Gly Lys His 
            100                 105                 110         


Ser Pro Met Val Ala Lys Ser Thr Leu Asp Ile Val Leu Ala Asn Lys 
        115                 120                 125             


Asp Arg Leu Asn Ser Ala Ile Ile Tyr Asp Arg Asp Phe Ser Tyr Asn 
    130                 135                 140                 


Tyr Phe Gly Phe Lys Thr Leu Glu Arg Ser Tyr Leu Leu Lys Ile Asn 
145                 150                 155                 160 


Gly Lys Val Ala Glu Arg Pro Gln His Met Leu Met Arg Val Ser Val 
                165                 170                 175     


Gly Ile His Lys Glu Asp Ile Asp Ala Ala Ile Glu Thr Tyr Asn Leu 
            180                 185                 190         


Leu Ser Glu Arg Trp Phe Thr His Ala Ser Pro Thr Leu Phe Asn Ala 
        195                 200                 205             


Gly Thr Asn Arg Pro Gln Leu Ser Ser Cys Phe Leu Leu Ser Met Lys 
    210                 215                 220                 


Asp Asp Ser Ile Glu Gly Ile Tyr Asp Thr Leu Lys Gln Cys Ala Leu 
225                 230                 235                 240 


Ile Ser Lys Ser Ala Gly Gly Ile Gly Val Ala Val Ser Cys Ile Arg 
                245                 250                 255     


Ala Thr Gly Ser Tyr Ile Ala Gly Thr Asn Gly Asn Ser Asn Gly Leu 
            260                 265                 270         


Val Pro Met Leu Arg Val Tyr Asn Asn Thr Ala Arg Tyr Val Asp Gln 
        275                 280                 285             


Gly Gly Asn Lys Arg Pro Gly Ala Phe Ala Ile Tyr Leu Glu Pro Trp 
    290                 295                 300                 


His Leu Asp Ile Phe Glu Phe Leu Asp Leu Lys Lys Asn Thr Gly Lys 
305                 310                 315                 320 


Glu Glu Gln Arg Ala Arg Asp Leu Phe Phe Ala Leu Trp Ile Pro Asp 
                325                 330                 335     


Leu Phe Met Lys Arg Val Glu Thr Asn Gln Asp Trp Ser Leu Met Cys 
            340                 345                 350         


Pro Asn Glu Cys Pro Gly Leu Asp Glu Val Trp Gly Glu Glu Phe Glu 
        355                 360                 365             


Lys Leu Tyr Ala Ser Tyr Glu Lys Gln Gly Arg Val Arg Lys Val Val 
    370                 375                 380                 


Lys Ala Gln Gln Leu Trp Tyr Ala Ile Ile Glu Ser Gln Thr Glu Thr 
385                 390                 395                 400 


Gly Thr Pro Tyr Met Leu Tyr Lys Asp Ser Cys Asn Arg Lys Ser Asn 
                405                 410                 415     


Gln Gln Asn Leu Gly Thr Ile Lys Cys Ser Asn Leu Cys Thr Glu Ile 
            420                 425                 430         


Val Glu Tyr Thr Ser Lys Asp Glu Val Ala Val Cys Asn Leu Ala Ser 
        435                 440                 445             


Leu Ala Leu Asn Met Tyr Val Thr Ser Glu His Thr Tyr Asp Phe Lys 
    450                 455                 460                 


Lys Leu Ala Glu Val Thr Lys Val Val Val Arg Asn Leu Asn Lys Ile 
465                 470                 475                 480 


Ile Asp Ile Asn Tyr Tyr Pro Val Pro Glu Ala Cys Leu Ser Asn Lys 
                485                 490                 495     


Arg His Arg Pro Ile Gly Ile Gly Val Gln Gly Leu Ala Asp Ala Phe 
            500                 505                 510         


Ile Leu Met Arg Tyr Pro Phe Glu Ser Ala Glu Ala Gln Leu Leu Asn 
        515                 520                 525             


Lys Gln Ile Phe Glu Thr Ile Tyr Tyr Gly Ala Leu Glu Ala Ser Cys 
    530                 535                 540                 


Asp Leu Ala Lys Glu Gln Gly Pro Tyr Glu Thr Tyr Glu Gly Ser Pro 
545                 550                 555                 560 


Val Ser Lys Gly Ile Leu Gln Tyr Asp Met Trp Asn Val Thr Pro Thr 
                565                 570                 575     


Asp Leu Trp Asp Trp Lys Val Leu Lys Glu Lys Ile Ala Lys Tyr Gly 
            580                 585                 590         


Ile Arg Asn Ser Leu Leu Ile Ala Pro Met Pro Thr Ala Ser Thr Ala 
        595                 600                 605             


Gln Ile Leu Gly Asn Asn Glu Ser Ile Glu Pro Tyr Thr Ser Asn Ile 
    610                 615                 620                 


Tyr Thr Arg Arg Val Leu Ser Gly Glu Phe Gln Ile Val Asn Pro His 
625                 630                 635                 640 


Leu Leu Lys Asp Leu Thr Glu Arg Gly Leu Trp His Glu Glu Met Lys 
                645                 650                 655     


Asn Gln Ile Ile Ala Cys Asn Gly Ser Ile Gln Ser Ile Pro Glu Ile 
            660                 665                 670         


Pro Asp Asp Leu Lys Gln Leu Tyr Lys Thr Val Trp Glu Ile Ser Gln 
        675                 680                 685             


Lys Thr Val Leu Lys Met Ala Ala Glu Arg Gly Ala Phe Ile Asp Gln 
    690                 695                 700                 


Ser Gln Ser Leu Asn Ile His Ile Ala Glu Pro Asn Tyr Gly Lys Leu 
705                 710                 715                 720 


Thr Ser Met His Phe Tyr Gly Trp Lys Gln Gly Leu Lys Thr Gly Met 
                725                 730                 735     


Tyr Tyr Leu Arg Thr Arg Pro Ala Ala Asn Pro Ile Gln Phe Thr Leu 
            740                 745                 750         


Asn Lys Glu Lys Leu Lys Asp Lys Glu Lys Val Ser Lys Glu Glu Glu 
        755                 760                 765             


Glu Lys Glu Arg Asn Thr Ala Ala Met Val Cys Ser Leu Glu Asn Arg 
    770                 775                 780                 


Asp Glu Cys Leu Met Cys Gly Ser 
785                 790         


<210>  86
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Met Cys Ser Ser Leu Glu Gln Ala Leu Ala Val Leu Val Thr Thr 
1               5                   10                  15      


Phe His Lys Tyr Ser Cys Gln Glu Gly Asp Lys Phe Lys Leu Ser Lys 
            20                  25                  30          


Gly Glu Met Lys Glu Leu Leu His Lys Glu Leu Pro Ser Phe Val Gly 
        35                  40                  45              


Glu Lys Val Asp Glu Glu Gly Leu Lys Lys Leu Met Gly Ser Leu Asp 
    50                  55                  60                  


Glu Asn Ser Asp Gln Gln Val Asp Phe Gln Glu Tyr Ala Val Phe Leu 
65                  70                  75                  80  


Ala Leu Ile Thr Val Met Cys Asn Asp Phe Phe Gln Gly Cys Pro Asp 
                85                  90                  95      


Arg Pro 
        


<210>  87
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Asn Ala Thr Gly Thr Pro Val Ala Pro Glu Ser Cys Gln Gln Leu 
1               5                   10                  15      


Ala Ala Gly Gly His Ser Arg Leu Ile Val Leu His Tyr Asn His Ser 
            20                  25                  30          


Gly Arg Leu Ala Gly Arg Gly Gly Pro Glu Asp Gly Gly Leu Gly Ala 
        35                  40                  45              


Leu Arg Gly Leu Ser Val Ala Ala Ser Cys Leu Val Val Leu Glu Asn 
    50                  55                  60                  


Leu Leu Val Leu Ala Ala Ile Thr Ser His Met Arg Ser Arg Arg Trp 
65                  70                  75                  80  


Val Tyr Tyr Cys Leu Val Asn Ile Thr Leu Ser Asp Leu Leu Thr Gly 
                85                  90                  95      


Ala Ala Tyr Leu Ala Asn Val Leu Leu Ser Gly Ala Arg Thr Phe Arg 
            100                 105                 110         


Leu Ala Pro Ala Gln Trp Phe Leu Arg Glu Gly Leu Leu Phe Thr Ala 
        115                 120                 125             


Leu Ala Ala Ser Thr Phe Ser Leu Leu Phe Thr Ala Gly Glu Arg Phe 
    130                 135                 140                 


Ala Thr Met Val Arg Pro Val Ala Glu Ser Gly Ala Thr Lys Thr Ser 
145                 150                 155                 160 


Arg Val Tyr Gly Phe Ile Gly Leu Cys Trp Leu Leu Ala Ala Leu Leu 
                165                 170                 175     


Gly Met Leu Pro Leu Leu Gly Trp Asn Cys Leu Cys Ala Phe Asp Arg 
            180                 185                 190         


Cys Ser Ser Leu Leu Pro Leu Tyr Ser Lys Arg Tyr Ile Leu Phe Cys 
        195                 200                 205             


Leu Val Ile Phe Ala Gly Val Leu Ala Thr Ile Met Gly Leu Tyr Gly 
    210                 215                 220                 


Ala Ile Phe Arg Leu Val Gln Ala Ser Gly Gln Lys Ala Pro Arg Pro 
225                 230                 235                 240 


Ala Ala Arg Arg Lys Ala Arg Arg Leu Leu Lys Thr Val Leu Met Ile 
                245                 250                 255     


Leu Leu Ala Phe Leu Val Cys Trp Gly Pro Leu Phe Gly Leu Leu Leu 
            260                 265                 270         


Ala Asp Val Phe Gly Ser Asn Leu Trp Ala Gln Glu Tyr Leu Arg Gly 
        275                 280                 285             


Met Asp Trp Ile Leu Ala Leu Ala Val Leu Asn Ser Ala Val Asn Pro 
    290                 295                 300                 


Ile Ile Tyr Ser Phe Arg Ser Arg Glu Val Cys Arg Ala Val Leu Ser 
305                 310                 315                 320 


Phe Leu Cys Cys Gly Cys Leu Arg Leu Gly Met Arg Gly Pro Gly Asp 
                325                 330                 335     


Cys Leu Ala Arg Ala Val Glu Ala His Ser Gly Ala Ser Thr Thr Asp 
            340                 345                 350         


Ser Ser Leu Arg Pro Arg Asp Ser Phe Arg Gly Ser Arg Ser Leu Ser 
        355                 360                 365             


Phe Arg Met Arg Glu Pro Leu Ser Ser Ile Ser Ser Val Arg Ser Ile 
    370                 375                 380                 


<210>  88
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ala Val Leu Trp Arg Leu Ser Ala Val Cys Gly Ala Leu Gly Gly 
1               5                   10                  15      


Arg Ala Leu Leu Leu Arg Thr Pro Val Val Arg Pro Ala His Ile Ser 
            20                  25                  30          


Ala Phe Leu Gln Asp Arg Pro Ile Pro Glu Trp Cys Gly Val Gln His 
        35                  40                  45              


Ile His Leu Ser Pro Ser His His Ser Gly Ser Lys Ala Ala Ser Leu 
    50                  55                  60                  


His Trp Thr Ser Glu Arg Val Val Ser Val Leu Leu Leu Gly Leu Leu 
65                  70                  75                  80  


Pro Ala Ala Tyr Leu Asn Pro Cys Ser Ala Met Asp Tyr Ser Leu Ala 
                85                  90                  95      


Ala Ala Leu Thr Leu His Gly His Trp Gly Leu Gly Gln Val Val Thr 
            100                 105                 110         


Asp Tyr Val His Gly Asp Ala Leu Gln Lys Ala Ala Lys Ala Gly Leu 
        115                 120                 125             


Leu Ala Leu Ser Ala Leu Thr Phe Ala Gly Leu Cys Tyr Phe Asn Tyr 
    130                 135                 140                 


His Asp Val Gly Ile Cys Lys Ala Val Ala Met Leu Trp Lys Leu 
145                 150                 155                 


<210>  89
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ser Val Asn Tyr Ala Ala Gly Leu Ser Pro Tyr Ala Asp Lys Gly 
1               5                   10                  15      


Lys Cys Gly Leu Pro Glu Ile Phe Asp Pro Pro Glu Glu Leu Glu Arg 
            20                  25                  30          


Lys Val Trp Glu Leu Ala Arg Leu Val Trp Gln Ser Ser Ser Val Val 
        35                  40                  45              


Phe His Thr Gly Ala Gly Ile Ser Thr Ala Ser Gly Ile Pro Asp Phe 
    50                  55                  60                  


Arg Gly Pro His Gly Val Trp Thr Met Glu Glu Arg Gly Leu Ala Pro 
65                  70                  75                  80  


Lys Phe Asp Thr Thr Phe Glu Ser Ala Arg Pro Thr Gln Thr His Met 
                85                  90                  95      


Ala Leu Val Gln Leu Glu Arg Val Gly Leu Leu Arg Phe Leu Val Ser 
            100                 105                 110         


Gln Asn Val Asp Gly Leu His Val Arg Ser Gly Phe Pro Arg Asp Lys 
        115                 120                 125             


Leu Ala Glu Leu His Gly Asn Met Phe Val Glu Glu Cys Ala Lys Cys 
    130                 135                 140                 


Lys Thr Gln Tyr Val Arg Asp Thr Val Val Gly Thr Met Gly Leu Lys 
145                 150                 155                 160 


Ala Thr Gly Arg Leu Cys Thr Val Ala Lys Ala Arg Gly Leu Arg Ala 
                165                 170                 175     


Cys Arg Gly Glu Leu Arg Asp Thr Ile Leu Asp Trp Glu Asp Ser Leu 
            180                 185                 190         


Pro Asp Arg Asp Leu Ala Leu Ala Asp Glu Ala Ser Arg Asn Ala Asp 
        195                 200                 205             


Leu Ser Ile Thr Leu Gly Thr Ser Leu Gln Ile Arg Pro Ser Gly Asn 
    210                 215                 220                 


Leu Pro Leu Ala Thr Lys Arg Arg Gly Gly Arg Leu Val Ile Val Asn 
225                 230                 235                 240 


Leu Gln Pro Thr Lys His Asp Arg His Ala Asp Leu Arg Ile His Gly 
                245                 250                 255     


Tyr Val Asp Glu Val Met Thr Arg Leu Met Lys His Leu Gly Leu Glu 
            260                 265                 270         


Ile Pro Ala Trp Asp Gly Pro Arg Val Leu Glu Arg Ala Leu Pro Pro 
        275                 280                 285             


Leu Pro Arg Pro Pro Thr Pro Lys Leu Glu Pro Lys Glu Glu Ser Pro 
    290                 295                 300                 


Thr Arg Ile Asn Gly Ser Ile Pro Ala Gly Pro Lys Gln Glu Pro Cys 
305                 310                 315                 320 


Ala Gln His Asn Gly Ser Glu Pro Ala Ser Pro Lys Arg Glu Arg Pro 
                325                 330                 335     


Thr Ser Pro Ala Pro His Arg Pro Pro Lys Arg Val Lys Ala Lys Ala 
            340                 345                 350         


Val Pro Ser 
        355 


<210>  90
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Ala Gly Gly Leu Ser Arg Ser Glu Arg Lys Ala Ala Glu Arg 
1               5                   10                  15      


Val Arg Arg Leu Arg Glu Glu Gln Gln Arg Glu Arg Leu Arg Gln Val 
            20                  25                  30          


Ser Arg Ile Leu Arg Lys Ala Ala Ala Glu Arg Ser Ala Glu Glu Gly 
        35                  40                  45              


Arg Leu Leu Ala Glu Ser Ala Asp Leu Val Thr Glu Leu Gln Gly Arg 
    50                  55                  60                  


Ser Arg Arg Arg Glu Gly Leu Lys Arg Arg Gln Glu Glu Val Cys Asp 
65                  70                  75                  80  


Asp Pro Glu Glu Leu Arg Gly Lys Val Arg Glu Leu Ala Ser Ala Val 
                85                  90                  95      


Arg Asn Ala Lys Tyr Leu Val Val Tyr Thr Gly Ala Gly Ile Ser Thr 
            100                 105                 110         


Ala Ala Ser Ile Pro Asp Tyr Arg Gly Pro Asn Gly Val Trp Thr Leu 
        115                 120                 125             


Leu Gln Lys Gly Arg Ser Val Ser Ala Ala Asp Leu Ser Glu Ala Glu 
    130                 135                 140                 


Pro Thr Leu Thr His Met Ser Ile Thr Arg Leu His Glu Gln Lys Leu 
145                 150                 155                 160 


Val Gln His Val Val Ser Gln Asn Cys Asp Gly Leu His Leu Arg Ser 
                165                 170                 175     


Gly Leu Pro Arg Thr Ala Ile Ser Glu Leu His Gly Asn Met Tyr Ile 
            180                 185                 190         


Glu Val Cys Thr Ser Cys Val Pro Asn Arg Glu Tyr Val Arg Val Phe 
        195                 200                 205             


Asp Val Thr Glu Arg Thr Ala Leu His Arg His Gln Thr Gly Arg Thr 
    210                 215                 220                 


Cys His Lys Cys Gly Thr Gln Leu Arg Asp Thr Ile Val His Phe Gly 
225                 230                 235                 240 


Glu Arg Gly Thr Leu Gly Gln Pro Leu Asn Trp Glu Ala Ala Thr Glu 
                245                 250                 255     


Ala Ala Ser Arg Ala Asp Thr Ile Leu Cys Leu Gly Ser Ser Leu Lys 
            260                 265                 270         


Val Leu Lys Lys Tyr Pro Arg Leu Trp Cys Met Thr Lys Pro Pro Ser 
        275                 280                 285             


Arg Arg Pro Lys Leu Tyr Ile Val Asn Leu Gln Trp Thr Pro Lys Asp 
    290                 295                 300                 


Asp Trp Ala Ala Leu Lys Leu His Gly Lys Cys Asp Asp Val Met Arg 
305                 310                 315                 320 


Leu Leu Met Ala Glu Leu Gly Leu Glu Ile Pro Ala Tyr Ser Arg Trp 
                325                 330                 335     


Gln Asp Pro Ile Phe Ser Leu Ala Thr Pro Leu Arg Ala Gly Glu Glu 
            340                 345                 350         


Gly Ser His Ser Arg Lys Ser Leu Cys Arg Ser Arg Glu Glu Ala Pro 
        355                 360                 365             


Pro Gly Asp Arg Gly Ala Pro Leu Ser Ser Ala Pro Ile Leu Gly Gly 
    370                 375                 380                 


Trp Phe Gly Arg Gly Cys Thr Lys Arg Thr Lys Arg Lys Lys Val Thr 
385                 390                 395                 400 


<210>  91
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Ser Phe Phe Asn Phe Arg Lys Ile Phe Lys Leu Gly Ser Glu Lys 
1               5                   10                  15      


Lys Lys Lys Gln Tyr Glu His Val Lys Arg Asp Leu Asn Pro Glu Asp 
            20                  25                  30          


Phe Trp Glu Ile Ile Gly Glu Leu Gly Asp Gly Ala Phe Gly Lys Val 
        35                  40                  45              


Tyr Lys Ala Gln Asn Lys Glu Thr Ser Val Leu Ala Ala Ala Lys Val 
    50                  55                  60                  


Ile Asp Thr Lys Ser Glu Glu Glu Leu Glu Asp Tyr Met Val Glu Ile 
65                  70                  75                  80  


Asp Ile Leu Ala Ser Cys Asp His Pro Asn Ile Val Lys Leu Leu Asp 
                85                  90                  95      


Ala Phe Tyr Tyr Glu Asn Asn Leu Trp Ile Leu Ile Glu Phe Cys Ala 
            100                 105                 110         


Gly Gly Ala Val Asp Ala Val Met Leu Glu Leu Glu Arg Pro Leu Thr 
        115                 120                 125             


Glu Ser Gln Ile Gln Val Val Cys Lys Gln Thr Leu Asp Ala Leu Asn 
    130                 135                 140                 


Tyr Leu His Asp Asn Lys Ile Ile His Arg Asp Leu Lys Ala Gly Asn 
145                 150                 155                 160 


Ile Leu Phe Thr Leu Asp Gly Asp Ile Lys Leu Ala Asp Phe Gly Val 
                165                 170                 175     


Ser Ala Lys Asn Thr Arg Thr Ile Gln Arg Arg Asp Ser Phe Ile Gly 
            180                 185                 190         


Thr Pro Tyr Trp Met Ala Pro Glu Val Val Met Cys Glu Thr Ser Lys 
        195                 200                 205             


Asp Arg Pro Tyr Asp Tyr Lys Ala Asp Val Trp Ser Leu Gly Ile Thr 
    210                 215                 220                 


Leu Ile Glu Met Ala Glu Ile Glu Pro Pro His His Glu Leu Asn Pro 
225                 230                 235                 240 


Met Arg Val Leu Leu Lys Ile Ala Lys Ser Glu Pro Pro Thr Leu Ala 
                245                 250                 255     


Gln Pro Ser Arg Trp Ser Ser Asn Phe Lys Asp Phe Leu Lys Lys Cys 
            260                 265                 270         


Leu Glu Lys Asn Val Asp Ala Arg Trp Thr Thr Ser Gln Leu Leu Gln 
        275                 280                 285             


His Pro Phe Val Thr Val Asp Ser Asn Lys Pro Ile Arg Glu Leu Ile 
    290                 295                 300                 


Ala Glu Ala Lys Ala Glu Val Thr Glu Glu Val Glu Asp Gly Lys Glu 
305                 310                 315                 320 


Glu Asp Glu Glu Glu Glu Thr Glu Asn Ser Leu Pro Ile Pro Ala Ser 
                325                 330                 335     


Lys Arg Ala Ser Ser Asp Leu Ser Ile Ala Ser Ser Glu Glu Asp Lys 
            340                 345                 350         


Leu Ser Gln Asn Ala Cys Ile Leu Glu Ser Val Ser Glu Lys Thr Glu 
        355                 360                 365             


Arg Ser Asn Ser Glu Asp Lys Leu Asn Ser Lys Ile Leu Asn Glu Lys 
    370                 375                 380                 


Pro Thr Thr Asp Glu Pro Glu Lys Ala Val Glu Asp Ile Asn Glu His 
385                 390                 395                 400 


Ile Thr Asp Ala Gln Leu Glu Ala Met Thr Glu Leu His Asp Arg Thr 
                405                 410                 415     


Ala Val Ile Lys Glu Asn Glu Arg Glu Lys Arg Pro Lys Leu Glu Asn 
            420                 425                 430         


Leu Pro Asp Thr Glu Asp Gln Glu Thr Val Asp Ile Asn Ser Val Ser 
        435                 440                 445             


Glu Gly Lys Glu Asn Asn Ile Met Ile Thr Leu Glu Thr Asn Ile Glu 
    450                 455                 460                 


His Asn Leu Lys Ser Glu Glu Glu Lys Asp Gln Glu Lys Gln Gln Met 
465                 470                 475                 480 


Phe Glu Asn Lys Leu Ile Lys Ser Glu Glu Ile Lys Asp Thr Ile Leu 
                485                 490                 495     


Gln Thr Val Asp Leu Val Ser Gln Glu Thr Gly Glu Lys Glu Ala Asn 
            500                 505                 510         


Ile Gln Ala Val Asp Ser Glu Val Gly Leu Thr Lys Glu Asp Thr Gln 
        515                 520                 525             


Glu Lys Leu Gly Glu Asp Asp Lys Thr Gln Lys Asp Val Ile Ser Asn 
    530                 535                 540                 


Thr Ser Asp Val Ile Gly Thr Cys Glu Ala Ala Asp Val Ala Gln Lys 
545                 550                 555                 560 


Val Asp Glu Asp Ser Ala Glu Asp Thr Gln Ser Asn Asp Gly Lys Glu 
                565                 570                 575     


Val Val Glu Val Gly Gln Lys Leu Ile Asn Lys Pro Met Val Gly Pro 
            580                 585                 590         


Glu Ala Gly Gly Thr Lys Glu Val Pro Ile Lys Glu Ile Val Glu Met 
        595                 600                 605             


Asn Glu Ile Glu Glu Gly Lys Asn Lys Glu Gln Ala Ile Asn Ser Ser 
    610                 615                 620                 


Glu Asn Ile Met Asp Ile Asn Glu Glu Pro Gly Thr Thr Glu Gly Glu 
625                 630                 635                 640 


Glu Ile Thr Glu Ser Ser Ser Thr Glu Glu Met Glu Val Arg Ser Val 
                645                 650                 655     


Val Ala Asp Thr Asp Gln Lys Ala Leu Gly Ser Glu Val Gln Asp Ala 
            660                 665                 670         


Ser Lys Val Thr Thr Gln Ile Asp Lys Glu Lys Lys Glu Ile Pro Val 
        675                 680                 685             


Ser Ile Lys Lys Glu Pro Glu Val Thr Val Val Ser Gln Pro Thr Glu 
    690                 695                 700                 


Pro Gln Pro Val Leu Ile Pro Ser Ile Asn Ile Asn Ser Asp Ser Gly 
705                 710                 715                 720 


Glu Asn Lys Glu Glu Ile Gly Ser Leu Ser Lys Thr Glu Thr Ile Leu 
                725                 730                 735     


Pro Pro Glu Ser Glu Asn Pro Lys Glu Asn Asp Asn Asp Ser Gly Thr 
            740                 745                 750         


Gly Ser Thr Ala Asp Thr Ser Ser Ile Asp Leu Asn Leu Ser Ile Ser 
        755                 760                 765             


Ser Phe Leu Ser Lys Thr Lys Asp Ser Gly Ser Ile Ser Leu Gln Glu 
    770                 775                 780                 


Thr Arg Arg Gln Lys Lys Thr Leu Lys Lys Thr Arg Lys Phe Ile Val 
785                 790                 795                 800 


Asp Gly Val Glu Val Ser Val Thr Thr Ser Lys Ile Val Thr Asp Ser 
                805                 810                 815     


Asp Ser Lys Thr Glu Glu Leu Arg Phe Leu Arg Arg Gln Glu Leu Arg 
            820                 825                 830         


Glu Leu Arg Phe Leu Gln Lys Glu Glu Gln Arg Ala Gln Gln Gln Leu 
        835                 840                 845             


Asn Ser Lys Leu Gln Gln Gln Arg Glu Gln Ile Phe Arg Arg Phe Glu 
    850                 855                 860                 


Gln Glu Met Met Ser Lys Lys Arg Gln Tyr Asp Gln Glu Ile Glu Asn 
865                 870                 875                 880 


Leu Glu Lys Gln Gln Lys Gln Thr Ile Glu Arg Leu Glu Gln Glu His 
                885                 890                 895     


Thr Asn Arg Leu Arg Asp Glu Ala Lys Arg Ile Lys Gly Glu Gln Glu 
            900                 905                 910         


Lys Glu Leu Ser Lys Phe Gln Asn Met Leu Lys Asn Arg Lys Lys Glu 
        915                 920                 925             


Val Ile Asn Glu Val Glu Lys Ala Pro Lys Glu Leu Arg Lys Glu Leu 
    930                 935                 940                 


Met Lys Arg Arg Lys Glu Glu Leu Ala Gln Ser Gln His Ala Gln Glu 
945                 950                 955                 960 


Gln Glu Phe Val Gln Lys Gln Gln Gln Glu Leu Asp Gly Ser Leu Lys 
                965                 970                 975     


Lys Ile Ile Gln Gln Gln Lys Ala Glu Leu Ala Asn Ile Glu Arg Glu 
            980                 985                 990         


Cys Leu Asn Asn Lys Gln Gln Leu  Met Arg Ala Arg Glu  Ala Ala Ile 
        995                 1000                 1005             


Trp Glu  Leu Glu Glu Arg His  Leu Gln Glu Lys His  Gln Leu Leu 
    1010                 1015                 1020             


Lys Gln  Gln Leu Lys Asp Gln  Tyr Phe Met Gln Arg  His Gln Leu 
    1025                 1030                 1035             


Leu Lys  Arg His Glu Lys Glu  Thr Glu Gln Met Gln  Arg Tyr Asn 
    1040                 1045                 1050             


Gln Arg  Leu Ile Glu Glu Leu  Lys Asn Arg Gln Thr  Gln Glu Arg 
    1055                 1060                 1065             


Ala Arg  Leu Pro Lys Ile Gln  Arg Ser Glu Ala Lys  Thr Arg Met 
    1070                 1075                 1080             


Ala Met  Phe Lys Lys Ser Leu  Arg Ile Asn Ser Thr  Ala Thr Pro 
    1085                 1090                 1095             


Asp Gln  Asp Arg Asp Lys Ile  Lys Gln Phe Ala Ala  Gln Glu Glu 
    1100                 1105                 1110             


Lys Arg  Gln Lys Asn Glu Arg  Met Ala Gln His Gln  Lys His Glu 
    1115                 1120                 1125             


Asn Gln  Met Arg Asp Leu Gln  Leu Gln Cys Glu Ala  Asn Val Arg 
    1130                 1135                 1140             


Glu Leu  His Gln Leu Gln Asn  Glu Lys Cys His Leu  Leu Val Glu 
    1145                 1150                 1155             


His Glu  Thr Gln Lys Leu Lys  Glu Leu Asp Glu Glu  His Ser Gln 
    1160                 1165                 1170             


Glu Leu  Lys Glu Trp Arg Glu  Lys Leu Arg Pro Arg  Lys Lys Thr 
    1175                 1180                 1185             


Leu Glu  Glu Glu Phe Ala Arg  Lys Leu Gln Glu Gln  Glu Val Phe 
    1190                 1195                 1200             


Phe Lys  Met Thr Gly Glu Ser  Glu Cys Leu Asn Pro  Ser Thr Gln 
    1205                 1210                 1215             


Ser Arg  Ile Ser Lys Phe Tyr  Pro Ile Pro Ser Leu  His Ser Thr 
    1220                 1225                 1230             


Gly Ser  
    1235 


<210>  92
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210>  93
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Gly Asn Val Leu Ala Ala Ser Ser Pro Pro Ala Gly Pro Pro Pro 
1               5                   10                  15      


Pro Pro Ala Pro Ala Leu Val Gly Leu Pro Pro Pro Pro Pro Ser Pro 
            20                  25                  30          


Pro Gly Phe Thr Leu Pro Pro Leu Gly Gly Ser Leu Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Arg Ser Ser Glu Arg Thr Pro Gly Ala Ala Thr Ala Ser 
    50                  55                  60                  


Ala Ser Gly Ala Ala Glu Asp Gly Ala Cys Gly Cys Leu Pro Asn Pro 
65                  70                  75                  80  


Gly Thr Phe Glu Glu Cys His Arg Lys Cys Lys Glu Leu Phe Pro Ile 
                85                  90                  95      


Gln Met Glu Gly Val Lys Leu Thr Val Asn Lys Gly Leu Ser Asn His 
            100                 105                 110         


Phe Gln Val Asn His Thr Val Ala Leu Ser Thr Ile Gly Glu Ser Asn 
        115                 120                 125             


Tyr His Phe Gly Val Thr Tyr Val Gly Thr Lys Gln Leu Ser Pro Thr 
    130                 135                 140                 


Glu Ala Phe Pro Val Leu Val Gly Asp Met Asp Asn Ser Gly Ser Leu 
145                 150                 155                 160 


Asn Ala Gln Val Ile His Gln Leu Gly Pro Gly Leu Arg Ser Lys Met 
                165                 170                 175     


Ala Ile Gln Thr Gln Gln Ser Lys Phe Val Asn Trp Gln Val Asp Gly 
            180                 185                 190         


Glu Tyr Arg Gly Ser Asp Phe Thr Ala Ala Val Thr Leu Gly Asn Pro 
        195                 200                 205             


Asp Val Leu Val Gly Ser Gly Ile Leu Val Ala His Tyr Leu Gln Ser 
    210                 215                 220                 


Ile Thr Pro Cys Leu Ala Leu Gly Gly Glu Leu Val Tyr His Arg Arg 
225                 230                 235                 240 


Pro Gly Glu Glu Gly Thr Val Met Ser Leu Ala Gly Lys Tyr Thr Leu 
                245                 250                 255     


Asn Asn Trp Leu Ala Thr Val Thr Leu Gly Gln Ala Gly Met His Ala 
            260                 265                 270         


Thr Tyr Tyr His Lys Ala Ser Asp Gln Leu Gln Val Gly Val Glu Phe 
        275                 280                 285             


Glu Ala Ser Thr Arg Met Gln Asp Thr Ser Val Ser Phe Gly Tyr Gln 
    290                 295                 300                 


Leu Asp Leu Pro Lys Ala Asn Leu Leu Phe Lys Gly Ser Val Asp Ser 
305                 310                 315                 320 


Asn Trp Ile Val Gly Ala Thr Leu Glu Lys Lys Leu Pro Pro Leu Pro 
                325                 330                 335     


Leu Thr Leu Ala Leu Gly Ala Phe Leu Asn His Arg Lys Asn Lys Phe 
            340                 345                 350         


Gln Cys Gly Phe Gly Leu Thr Ile Gly 
        355                 360     


<210>  94
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr 
1               5                   10                  15      


Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg 
            20                  25                  30          


Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly 
        35                  40                  45              


Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly 
    50                  55                  60                  


Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala 
65                  70                  75                  80  


Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys 
                85                  90                  95      


Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe 
            100                 105                 110         


Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp 
        115                 120                 125             


Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp 
    130                 135                 140                 


Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly 
145                 150                 155                 160 


Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile 
                165                 170                 175     


Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val 
            180                 185                 190         


Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile 
        195                 200                 205             


Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu 
    210                 215                 220                 


Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln 
225                 230                 235                 240 


Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys 
                245                 250                 255     


Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala 
            260                 265                 270         


Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln 
        275                 280                 285     


<210>  95
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Arg Gln Ala Asn Arg Gly Thr Glu Ser Lys Lys Met Ser Ser 
1               5                   10                  15      


Glu Leu Phe Thr Leu Thr Tyr Gly Ala Leu Val Thr Gln Leu Cys Lys 
            20                  25                  30          


Asp Tyr Glu Asn Asp Glu Asp Val Asn Lys Gln Leu Asp Lys Met Gly 
        35                  40                  45              


Phe Asn Ile Gly Val Arg Leu Ile Glu Asp Phe Leu Ala Arg Ser Asn 
    50                  55                  60                  


Val Gly Arg Cys His Asp Phe Arg Glu Thr Ala Asp Val Ile Ala Lys 
65                  70                  75                  80  


Val Ala Phe Lys Met Tyr Leu Gly Ile Thr Pro Ser Ile Thr Asn Trp 
                85                  90                  95      


Ser Pro Ala Gly Asp Glu Phe Ser Leu Ile Leu Glu Asn Asn Pro Leu 
            100                 105                 110         


Val Asp Phe Val Glu Leu Pro Asp Asn His Ser Ser Leu Ile Tyr Ser 
        115                 120                 125             


Asn Leu Leu Cys Gly Val Leu Arg Gly Ala Leu Glu Met Val Gln Met 
    130                 135                 140                 


Ala Val Glu Ala Lys Phe Val Gln Asp Thr Leu Lys Gly Asp Gly Val 
145                 150                 155                 160 


Thr Glu Ile Arg Met Arg Phe Ile Arg Arg Ile Glu Asp Asn Leu Pro 
                165                 170                 175     


Ala Gly Glu Glu 
            180 


<210>  96
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Arg Glu Ile Val His Leu Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Asn 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Asn Tyr Val Pro Arg Ala Val 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ala Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Phe Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ser Val Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Ala Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Gly Glu Phe Glu Glu Glu Ala Glu Glu Glu Val Ala 
        435                 440                 


<210>  97
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Pro Val Ala Gly Ser Glu Leu Pro Arg Arg Pro Leu Pro Pro Ala 
1               5                   10                  15      


Ala Gln Glu Arg Asp Ala Glu Pro Arg Pro Pro His Gly Glu Leu Gln 
            20                  25                  30          


Tyr Leu Gly Gln Ile Gln His Ile Leu Arg Cys Gly Val Arg Lys Asp 
        35                  40                  45              


Asp Arg Thr Gly Thr Gly Thr Leu Ser Val Phe Gly Met Gln Ala Arg 
    50                  55                  60                  


Tyr Ser Leu Arg Asp Glu Phe Pro Leu Leu Thr Thr Lys Arg Val Phe 
65                  70                  75                  80  


Trp Lys Gly Val Leu Glu Glu Leu Leu Trp Phe Ile Lys Gly Ser Thr 
                85                  90                  95      


Asn Ala Lys Glu Leu Ser Ser Lys Gly Val Lys Ile Trp Asp Ala Asn 
            100                 105                 110         


Gly Ser Arg Asp Phe Leu Asp Ser Leu Gly Phe Ser Thr Arg Glu Glu 
        115                 120                 125             


Gly Asp Leu Gly Pro Val Tyr Gly Phe Gln Trp Arg His Phe Gly Ala 
    130                 135                 140                 


Glu Tyr Arg Asp Met Glu Ser Asp Tyr Ser Gly Gln Gly Val Asp Gln 
145                 150                 155                 160 


Leu Gln Arg Val Ile Asp Thr Ile Lys Thr Asn Pro Asp Asp Arg Arg 
                165                 170                 175     


Ile Ile Met Cys Ala Trp Asn Pro Arg Asp Leu Pro Leu Met Ala Leu 
            180                 185                 190         


Pro Pro Cys His Ala Leu Cys Gln Phe Tyr Val Val Asn Ser Glu Leu 
        195                 200                 205             


Ser Cys Gln Leu Tyr Gln Arg Ser Gly Asp Met Gly Leu Gly Val Pro 
    210                 215                 220                 


Phe Asn Ile Ala Ser Tyr Ala Leu Leu Thr Tyr Met Ile Ala His Ile 
225                 230                 235                 240 


Thr Gly Leu Lys Pro Gly Asp Phe Ile His Thr Leu Gly Asp Ala His 
                245                 250                 255     


Ile Tyr Leu Asn His Ile Glu Pro Leu Lys Ile Gln Leu Gln Arg Glu 
            260                 265                 270         


Pro Arg Pro Phe Pro Lys Leu Arg Ile Leu Arg Lys Val Glu Lys Ile 
        275                 280                 285             


Asp Asp Phe Lys Ala Glu Asp Phe Gln Ile Glu Gly Tyr Asn Pro His 
    290                 295                 300                 


Pro Thr Ile Lys Met Glu Met Ala Val 
305                 310             


<210>  98
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Asp Gly Glu Glu Pro Glu Lys Lys Arg Arg Arg Ile Glu Glu 
1               5                   10                  15      


Leu Leu Ala Glu Lys Met Ala Val Asp Gly Gly Cys Gly Asp Thr Gly 
            20                  25                  30          


Asp Trp Glu Gly Arg Trp Asn His Val Lys Lys Phe Leu Glu Arg Ser 
        35                  40                  45              


Gly Pro Phe Thr His Pro Asp Phe Glu Pro Ser Thr Glu Ser Leu Gln 
    50                  55                  60                  


Phe Leu Leu Asp Thr Cys Lys Val Leu Val Ile Gly Ala Gly Gly Leu 
65                  70                  75                  80  


Gly Cys Glu Leu Leu Lys Asn Leu Ala Leu Ser Gly Phe Arg Gln Ile 
                85                  90                  95      


His Val Ile Asp Met Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln 
            100                 105                 110         


Phe Leu Phe Arg Pro Lys Asp Ile Gly Arg Pro Lys Ala Glu Val Ala 
        115                 120                 125             


Ala Glu Phe Leu Asn Asp Arg Val Pro Asn Cys Asn Val Val Pro His 
    130                 135                 140                 


Phe Asn Lys Ile Gln Asp Phe Asn Asp Thr Phe Tyr Arg Gln Phe His 
145                 150                 155                 160 


Ile Ile Val Cys Gly Leu Asp Ser Ile Ile Ala Arg Arg Trp Ile Asn 
                165                 170                 175     


Gly Met Leu Ile Ser Leu Leu Asn Tyr Glu Asp Gly Val Leu Asp Pro 
            180                 185                 190         


Ser Ser Ile Val Pro Leu Ile Asp Gly Gly Thr Glu Gly Phe Lys Gly 
        195                 200                 205             


Asn Ala Arg Val Ile Leu Pro Gly Met Thr Ala Cys Ile Glu Cys Thr 
    210                 215                 220                 


Leu Glu Leu Tyr Pro Pro Gln Val Asn Phe Pro Met Cys Thr Ile Ala 
225                 230                 235                 240 


Ser Met Pro Arg Leu Pro Glu His Cys Ile Glu Tyr Val Arg Met Leu 
                245                 250                 255     


Gln Trp Pro Lys Glu Gln Pro Phe Gly Glu Gly Val Pro Leu Asp Gly 
            260                 265                 270         


Asp Asp Pro Glu His Ile Gln Trp Ile Phe Gln Lys Ser Leu Glu Arg 
        275                 280                 285             


Ala Ser Gln Tyr Asn Ile Arg Gly Val Thr Tyr Arg Leu Thr Gln Gly 
    290                 295                 300                 


Val Val Lys Arg Ile Ile Pro Ala Val Ala Ser Thr Asn Ala Val Ile 
305                 310                 315                 320 


Ala Ala Val Cys Ala Thr Glu Val Phe Lys Ile Ala Thr Ser Ala Tyr 
                325                 330                 335     


Ile Pro Leu Asn Asn Tyr Leu Val Phe Asn Asp Val Asp Gly Leu Tyr 
            340                 345                 350         


Thr Tyr Thr Phe Glu Ala Glu Arg Lys Glu Asn Cys Pro Ala Cys Ser 
        355                 360                 365             


Gln Leu Pro Gln Asn Ile Gln Phe Ser Pro Ser Ala Lys Leu Gln Glu 
    370                 375                 380                 


Val Leu Asp Tyr Leu Thr Asn Ser Ala Ser Leu Gln Met Lys Ser Pro 
385                 390                 395                 400 


Ala Ile Thr Ala Thr Leu Glu Gly Lys Asn Arg Thr Leu Tyr Leu Gln 
                405                 410                 415     


Ser Val Thr Ser Ile Glu Glu Arg Thr Arg Pro Asn Leu Ser Lys Thr 
            420                 425                 430         


Leu Lys Glu Leu Gly Leu Val Asp Gly Gln Glu Leu Ala Val Ala Asp 
        435                 440                 445             


Val Thr Thr Pro Gln Thr Val Leu Phe Lys Leu His Phe Thr Ser 
    450                 455                 460             


<210>  99
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Gly Lys Gln Ala Val Ser Ala Ser Gly Lys Trp Leu Asp Gly 
1               5                   10                  15      


Ile Arg Lys Trp Tyr Tyr Asn Ala Ala Gly Phe Asn Lys Leu Gly Leu 
            20                  25                  30          


Met Arg Asp Asp Thr Ile Tyr Glu Asp Glu Asp Val Lys Glu Ala Ile 
        35                  40                  45              


Arg Arg Leu Pro Glu Asn Leu Tyr Asn Asp Arg Met Phe Arg Ile Lys 
    50                  55                  60                  


Arg Ala Leu Asp Leu Asn Leu Lys His Gln Ile Leu Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Thr Lys Tyr Glu Glu Glu Asn Phe Tyr Leu Glu Pro Tyr Leu Lys 
                85                  90                  95      


Glu Val Ile Arg Glu Arg Lys Glu Arg Glu Glu Trp Ala Lys Lys 
            100                 105                 110     


<210>  100
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Glu Ala Asn Gly Leu Gly Pro Gln Gly Phe Pro Glu Leu Lys Asn 
1               5                   10                  15      


Asp Thr Phe Leu Arg Ala Ala Trp Gly Glu Glu Thr Asp Tyr Thr Pro 
            20                  25                  30          


Val Trp Cys Met Arg Gln Ala Gly Arg Tyr Leu Pro Glu Phe Arg Glu 
        35                  40                  45              


Thr Arg Ala Ala Gln Asp Phe Phe Ser Thr Cys Arg Ser Pro Glu Ala 
    50                  55                  60                  


Cys Cys Glu Leu Thr Leu Gln Pro Leu Arg Arg Phe Pro Leu Asp Ala 
65                  70                  75                  80  


Ala Ile Ile Phe Ser Asp Ile Leu Val Val Pro Gln Ala Leu Gly Met 
                85                  90                  95      


Glu Val Thr Met Val Pro Gly Lys Gly Pro Ser Phe Pro Glu Pro Leu 
            100                 105                 110         


Arg Glu Glu Gln Asp Leu Glu Arg Leu Arg Asp Pro Glu Val Val Ala 
        115                 120                 125             


Ser Glu Leu Gly Tyr Val Phe Gln Ala Ile Thr Leu Thr Arg Gln Arg 
    130                 135                 140                 


Leu Ala Gly Arg Val Pro Leu Ile Gly Phe Ala Gly Ala Pro Trp Thr 
145                 150                 155                 160 


Leu Met Thr Tyr Met Val Glu Gly Gly Gly Ser Ser Thr Met Ala Gln 
                165                 170                 175     


Ala Lys Arg Trp Leu Tyr Gln Arg Pro Gln Ala Ser His Gln Leu Leu 
            180                 185                 190         


Arg Ile Leu Thr Asp Ala Leu Val Pro Tyr Leu Val Gly Gln Val Val 
        195                 200                 205             


Ala Gly Ala Gln Ala Leu Gln Leu Phe Glu Ser His Ala Gly His Leu 
    210                 215                 220                 


Gly Pro Gln Leu Phe Asn Lys Phe Ala Leu Pro Tyr Ile Arg Asp Val 
225                 230                 235                 240 


Ala Lys Gln Val Lys Ala Arg Leu Arg Glu Ala Gly Leu Ala Pro Val 
                245                 250                 255     


Pro Met Ile Ile Phe Ala Lys Asp Gly His Phe Ala Leu Glu Glu Leu 
            260                 265                 270         


Ala Gln Ala Gly Tyr Glu Val Val Gly Leu Asp Trp Thr Val Ala Pro 
        275                 280                 285             


Lys Lys Ala Arg Glu Cys Val Gly Lys Thr Val Thr Leu Gln Gly Asn 
    290                 295                 300                 


Leu Asp Pro Cys Ala Leu Tyr Ala Ser Glu Glu Glu Ile Gly Gln Leu 
305                 310                 315                 320 


Val Lys Gln Met Leu Asp Asp Phe Gly Pro His Arg Tyr Ile Ala Asn 
                325                 330                 335     


Leu Gly His Gly Leu Tyr Pro Asp Met Asp Pro Glu His Val Gly Ala 
            340                 345                 350         


Phe Val Asp Ala Val His Lys His Ser Arg Leu Leu Arg Gln Asn 
        355                 360                 365         


<210>  101
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


<210>  102
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Ser Gly Ala Asp Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile 
1               5                   10                  15      


Leu Lys Gln Lys Asn Arg Pro Asn Arg Leu Ile Val Asp Glu Ala Ile 
            20                  25                  30          


Asn Glu Asp Asn Ser Val Val Ser Leu Ser Gln Pro Lys Met Asp Glu 
        35                  40                  45              


Leu Gln Leu Phe Arg Gly Asp Thr Val Leu Leu Lys Gly Lys Lys Arg 
    50                  55                  60                  


Arg Glu Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser Asp Glu 
65                  70                  75                  80  


Lys Ile Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val Arg Leu 
                85                  90                  95      


Gly Asp Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys 
            100                 105                 110         


Arg Ile His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile Thr Gly 
        115                 120                 125             


Asn Leu Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg 
    130                 135                 140                 


Pro Ile Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met Arg Ala 
145                 150                 155                 160 


Val Glu Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val 
                165                 170                 175     


Ala Pro Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys Arg Glu 
            180                 185                 190         


Asp Glu Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly 
        195                 200                 205             


Cys Arg Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu Pro Leu 
    210                 215                 220                 


Arg His Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro Arg Gly 
225                 230                 235                 240 


Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg 
                245                 250                 255     


Ala Val Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro 
            260                 265                 270         


Glu Ile Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys 
        275                 280                 285             


Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp 
    290                 295                 300                 


Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu Val 
305                 310                 315                 320 


Glu Arg Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly Leu Lys 
                325                 330                 335     


Gln Arg Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro Asn Ser 
            340                 345                 350         


Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu Val Asp 
        355                 360                 365             


Ile Gly Ile Pro Asp Ala Thr Gly Arg Leu Glu Ile Leu Gln Ile His 
    370                 375                 380                 


Thr Lys Asn Met Lys Leu Ala Asp Asp Val Asp Leu Glu Gln Val Ala 
385                 390                 395                 400 


Asn Glu Thr His Gly His Val Gly Ala Asp Leu Ala Ala Leu Cys Ser 
                405                 410                 415     


Glu Ala Ala Leu Gln Ala Ile Arg Lys Lys Met Asp Leu Ile Asp Leu 
            420                 425                 430         


Glu Asp Glu Thr Ile Asp Ala Glu Val Met Asn Ser Leu Ala Val Thr 
        435                 440                 445             


Met Asp Asp Phe Arg Trp Ala Leu Ser Gln Ser Asn Pro Ser Ala Leu 
    450                 455                 460                 


Arg Glu Thr Val Val Glu Val Pro Gln Val Thr Trp Glu Asp Ile Gly 
465                 470                 475                 480 


Gly Leu Glu Asp Val Lys Arg Glu Leu Gln Glu Leu Val Gln Tyr Pro 
                485                 490                 495     


Val Glu His Pro Asp Lys Phe Leu Lys Phe Gly Met Thr Pro Ser Lys 
            500                 505                 510         


Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala 
        515                 520                 525             


Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn Phe Ile Ser Ile Lys Gly 
    530                 535                 540                 


Pro Glu Leu Leu Thr Met Trp Phe Gly Glu Ser Glu Ala Asn Val Arg 
545                 550                 555                 560 


Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala Pro Cys Val Leu Phe Phe 
                565                 570                 575     


Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg Gly Gly Asn Ile Gly Asp 
            580                 585                 590         


Gly Gly Gly Ala Ala Asp Arg Val Ile Asn Gln Ile Leu Thr Glu Met 
        595                 600                 605             


Asp Gly Met Ser Thr Lys Lys Asn Val Phe Ile Ile Gly Ala Thr Asn 
    610                 615                 620                 


Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp 
625                 630                 635                 640 


Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu Lys Ser Arg Val Ala Ile 
                645                 650                 655     


Leu Lys Ala Asn Leu Arg Lys Ser Pro Val Ala Lys Asp Val Asp Leu 
            660                 665                 670         


Glu Phe Leu Ala Lys Met Thr Asn Gly Phe Ser Gly Ala Asp Leu Thr 
        675                 680                 685             


Glu Ile Cys Gln Arg Ala Cys Lys Leu Ala Ile Arg Glu Ser Ile Glu 
    690                 695                 700                 


Ser Glu Ile Arg Arg Glu Arg Glu Arg Gln Thr Asn Pro Ser Ala Met 
705                 710                 715                 720 


Glu Val Glu Glu Asp Asp Pro Val Pro Glu Ile Arg Arg Asp His Phe 
                725                 730                 735     


Glu Glu Ala Met Arg Phe Ala Arg Arg Ser Val Ser Asp Asn Asp Ile 
            740                 745                 750         


Arg Lys Tyr Glu Met Phe Ala Gln Thr Leu Gln Gln Ser Arg Gly Phe 
        755                 760                 765             


Gly Ser Phe Arg Phe Pro Ser Gly Asn Gln Gly Gly Ala Gly Pro Ser 
    770                 775                 780                 


Gln Gly Ser Gly Gly Gly Thr Gly Gly Ser Val Tyr Thr Glu Asp Asn 
785                 790                 795                 800 


Asp Asp Asp Leu Tyr Gly 
                805     


<210>  103
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Val Pro Pro Thr Tyr Ala Asp Leu Gly Lys Ser Ala Arg Asp 
1               5                   10                  15      


Val Phe Thr Lys Gly Tyr Gly Phe Gly Leu Ile Lys Leu Asp Leu Lys 
            20                  25                  30          


Thr Lys Ser Glu Asn Gly Leu Glu Phe Thr Ser Ser Gly Ser Ala Asn 
        35                  40                  45              


Thr Glu Thr Thr Lys Val Thr Gly Ser Leu Glu Thr Lys Tyr Arg Trp 
    50                  55                  60                  


Thr Glu Tyr Gly Leu Thr Phe Thr Glu Lys Trp Asn Thr Asp Asn Thr 
65                  70                  75                  80  


Leu Gly Thr Glu Ile Thr Val Glu Asp Gln Leu Ala Arg Gly Leu Lys 
                85                  90                  95      


Leu Thr Phe Asp Ser Ser Phe Ser Pro Asn Thr Gly Lys Lys Asn Ala 
            100                 105                 110         


Lys Ile Lys Thr Gly Tyr Lys Arg Glu His Ile Asn Leu Gly Cys Asp 
        115                 120                 125             


Met Asp Phe Asp Ile Ala Gly Pro Ser Ile Arg Gly Ala Leu Val Leu 
    130                 135                 140                 


Gly Tyr Glu Gly Trp Leu Ala Gly Tyr Gln Met Asn Phe Glu Thr Ala 
145                 150                 155                 160 


Lys Ser Arg Val Thr Gln Ser Asn Phe Ala Val Gly Tyr Lys Thr Asp 
                165                 170                 175     


Glu Phe Gln Leu His Thr Asn Val Asn Asp Gly Thr Glu Phe Gly Gly 
            180                 185                 190         


Ser Ile Tyr Gln Lys Val Asn Lys Lys Leu Glu Thr Ala Val Asn Leu 
        195                 200                 205             


Ala Trp Thr Ala Gly Asn Ser Asn Thr Arg Phe Gly Ile Ala Ala Lys 
    210                 215                 220                 


Tyr Gln Ile Asp Pro Asp Ala Cys Phe Ser Ala Lys Val Asn Asn Ser 
225                 230                 235                 240 


Ser Leu Ile Gly Leu Gly Tyr Thr Gln Thr Leu Lys Pro Gly Ile Lys 
                245                 250                 255     


Leu Thr Leu Ser Ala Leu Leu Asp Gly Lys Asn Val Asn Ala Gly Gly 
            260                 265                 270         


His Lys Leu Gly Leu Gly Leu Glu Phe Gln Ala 
        275                 280             


<210>  104
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile 
1               5                   10                  15      


Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser 
            20                  25                  30          


Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met 
        35                  40                  45              


Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro 
    50                  55                  60                  


Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala 
65                  70                  75                  80  


Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys 
                85                  90                  95      


Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile 
            100                 105                 110         


Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro 
        115                 120                 125             


His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn 
    130                 135                 140                 


Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr 
145                 150                 155                 160 


Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro 
                165                 170                 175     


Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val 
            180                 185                 190         


Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu 
        195                 200                 205             


Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala 
    210                 215                 220                 


Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr 
225                 230                 235                 240 


Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys 
                245                 250                 255     


His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser 
            260                 265                 270         


Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser 
        275                 280                 285             


Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln 
    290                 295                 300                 


Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr 
305                 310                 315                 320 


Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His 
                325                 330                 335     


Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala 
            340                 345                 350         


Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile 
        355                 360                 365             


Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile 
    370                 375                 380                 


Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe 
385                 390                 395                 400 


Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile 
                405                 410                 415     


Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys 
            420                 425                 430         


Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg 
        435                 440                 445             


Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg 
    450                 455                 460                 


Lys Leu Ser Phe Asp Phe Gln 
465                 470     


<210>  105
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile 
1               5                   10                  15      


Arg Ala Leu His Lys Gly Ser Ala Ala Ala Pro Ala Leu Gln Lys Asp 
            20                  25                  30          


Ser Lys Lys Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu His 
        35                  40                  45              


Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Arg Leu Gln Asp 
    50                  55                  60                  


Glu Tyr Asp Ser Val Leu Tyr Ser Ile Val Asp Leu His Ser Ile Thr 
65                  70                  75                  80  


Val Pro Gln Asp Pro Ala Val Leu Arg Gln Ser Ile Leu Asp Met Thr 
                85                  90                  95      


Ala Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile Leu Phe 
            100                 105                 110         


Gln Gln Ser Gln Val Ser Glu His Thr Gln Leu Ser Trp Ile Leu Ser 
        115                 120                 125             


Cys Met Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp Lys Ala 
    130                 135                 140                 


Lys Thr Thr Lys Gln Lys His Asp Gly Thr Val Gly Leu Leu Thr Tyr 
145                 150                 155                 160 


Pro Val Leu Gln Ala Ala Asp Ile Leu Leu Tyr Lys Ser Thr His Val 
                165                 170                 175     


Pro Val Gly Glu Asp Gln Val Gln His Met Glu Leu Val Gln Asp Leu 
            180                 185                 190         


Ala Gln Gly Phe Asn Lys Lys Tyr Gly Glu Phe Phe Pro Val Pro Glu 
        195                 200                 205             


Ser Ile Leu Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp Pro Ser 
    210                 215                 220                 


Ala Lys Met Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val Arg Ile 
225                 230                 235                 240 


Thr Asp Ser Pro Glu Glu Ile Val Gln Lys Phe Arg Lys Ala Val Thr 
                245                 250                 255     


Asp Phe Thr Ser Glu Val Thr Tyr Asp Pro Ala Gly Arg Ala Gly Val 
            260                 265                 270         


Ser Asn Ile Val Ala Val His Ala Ala Val Thr Gly Leu Ser Val Glu 
        275                 280                 285             


Glu Val Val Arg Arg Ser Ala Gly Met Asn Thr Ala Arg Tyr Lys Leu 
    290                 295                 300                 


Ala Val Ala Asp Ala Val Ile Glu Lys Phe Ala Pro Ile Lys Arg Glu 
305                 310                 315                 320 


Ile Glu Lys Leu Lys Leu Asp Lys Asp His Leu Glu Lys Val Leu Gln 
                325                 330                 335     


Ile Gly Ser Ala Lys Ala Lys Glu Leu Ala Tyr Thr Val Cys Gln Glu 
            340                 345                 350         


Val Lys Lys Leu Val Gly Phe Leu 
        355                 360 


<210>  106
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Asp Leu Asp Leu Leu Asp Leu Asn Pro Arg Ile Ile Ala Ala Ile 
1               5                   10                  15      


Lys Lys Ala Lys Leu Lys Ser Val Lys Glu Val Leu His Phe Ser Gly 
            20                  25                  30          


Pro Asp Leu Lys Arg Leu Thr Asn Leu Ser Ser Pro Glu Val Trp His 
        35                  40                  45              


Leu Leu Arg Thr Ala Ser Leu His Leu Arg Gly Ser Ser Ile Leu Thr 
    50                  55                  60                  


Ala Leu Gln Leu His Gln Gln Lys Glu Arg Phe Pro Thr Gln His Gln 
65                  70                  75                  80  


Arg Leu Ser Leu Gly Cys Pro Val Leu Asp Ala Leu Leu Arg Gly Gly 
                85                  90                  95      


Leu Pro Leu Asp Gly Ile Thr Glu Leu Ala Gly Arg Ser Ser Ala Gly 
            100                 105                 110         


Lys Thr Gln Leu Ala Leu Gln Leu Cys Leu Ala Val Gln Phe Pro Arg 
        115                 120                 125             


Gln His Gly Gly Leu Glu Ala Gly Ala Val Tyr Ile Cys Thr Glu Asp 
    130                 135                 140                 


Ala Phe Pro His Lys Arg Leu Gln Gln Leu Met Ala Gln Gln Pro Arg 
145                 150                 155                 160 


Leu Arg Thr Asp Val Pro Gly Glu Leu Leu Gln Lys Leu Arg Phe Gly 
                165                 170                 175     


Ser Gln Ile Phe Ile Glu His Val Ala Asp Val Asp Thr Leu Leu Glu 
            180                 185                 190         


Cys Val Asn Lys Lys Val Pro Val Leu Leu Ser Arg Gly Met Ala Arg 
        195                 200                 205             


Leu Val Val Ile Asp Ser Val Ala Ala Pro Phe Arg Cys Glu Phe Asp 
    210                 215                 220                 


Ser Gln Ala Ser Ala Pro Arg Ala Arg His Leu Gln Ser Leu Gly Ala 
225                 230                 235                 240 


Thr Leu Arg Glu Leu Ser Ser Ala Phe Gln Ser Pro Val Leu Cys Ile 
                245                 250                 255     


Asn Gln Val Thr Glu Ala Met Glu Glu Gln Gly Ala Ala His Gly Pro 
            260                 265                 270         


Leu Gly Phe Trp Asp Glu Arg Val Ser Pro Ala Leu Gly Ile Thr Trp 
        275                 280                 285             


Ala Asn Gln Leu Leu Val Arg Leu Leu Ala Asp Arg Leu Arg Glu Glu 
    290                 295                 300                 


Glu Ala Ala Leu Gly Cys Pro Ala Arg Thr Leu Arg Val Leu Ser Ala 
305                 310                 315                 320 


Pro His Leu Pro Pro Ser Ser Cys Ser Tyr Thr Ile Ser Ala Glu Gly 
                325                 330                 335     


Val Arg Gly Thr Pro Gly Thr Gln Ser His 
            340                 345     


<210>  107
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Arg Asn Val Val Tyr Pro Leu Tyr Arg Leu Gly Gly Pro Gln 
1               5                   10                  15      


Leu Arg Val Phe Arg Thr Asn Phe Phe Ile Gln Leu Val Arg Pro Gly 
            20                  25                  30          


Val Ala Gln Pro Glu Asp Thr Val Gln Phe Arg Ile Pro Met Glu Met 
        35                  40                  45              


Thr Arg Val Asp Leu Arg Asn Tyr Leu Glu Gly Ile Tyr Asn Val Pro 
    50                  55                  60                  


Val Ala Ala Val Arg Thr Arg Val Gln His Gly Ser Asn Lys Arg Arg 
65                  70                  75                  80  


Asp His Arg Asn Val Arg Ile Lys Lys Pro Asp Tyr Lys Val Ala Tyr 
                85                  90                  95      


Val Gln Leu Ala His Gly Gln Thr Phe Thr Phe Pro Asp Leu Phe Pro 
            100                 105                 110         


Glu Lys Asp Glu Ser Pro Glu Gly Ser Ala Ala Asp Asp Leu Tyr Ser 
        115                 120                 125             


Met Leu Glu Glu Glu Arg Gln Gln Arg Gln Ser Ser Asp Pro Arg Arg 
    130                 135                 140                 


Gly Gly Val Pro Ser Trp Phe Gly Leu 
145                 150             


<210>  108
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Lys Phe Asn Pro Phe Val Thr Ser Asp Arg Ser Lys Asn Arg Lys 
1               5                   10                  15      


Arg His Phe Asn Ala Pro Ser His Ile Arg Arg Lys Ile Met Ser Ser 
            20                  25                  30          


Pro Leu Ser Lys Glu Leu Arg Gln Lys Tyr Asn Val Arg Ser Met Pro 
        35                  40                  45              


Ile Arg Lys Asp Asp Glu Val Gln Val Val Arg Gly His Tyr Lys Gly 
    50                  55                  60                  


Gln Gln Ile Gly Lys Val Val Gln Val Tyr Arg Lys Lys Tyr Val Ile 
65                  70                  75                  80  


Tyr Ile Glu Arg Val Gln Arg Glu Lys Ala Asn Gly Thr Thr Val His 
                85                  90                  95      


Val Gly Ile His Pro Ser Lys Val Val Ile Thr Arg Leu Lys Leu Asp 
            100                 105                 110         


Lys Asp Arg Lys Lys Ile Leu Glu Arg Lys Ala Lys Ser Arg Gln Val 
        115                 120                 125             


Gly Lys Glu Lys Gly Lys Tyr Lys Glu Glu Thr Ile Glu Lys Met Gln 
    130                 135                 140                 


Glu 
145 


<210>  109
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Ala Leu Arg Pro Leu Val Lys Pro Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Thr Lys Lys Phe Ile Arg His Gln Ser Asp Arg Tyr Val Lys Ile Lys 
            20                  25                  30          


Arg Asn Trp Arg Lys Pro Arg Gly Ile Asp Asn Arg Val Arg Arg Arg 
        35                  40                  45              


Phe Lys Gly Gln Ile Leu Met Pro Asn Ile Gly Tyr Gly Ser Asn Lys 
    50                  55                  60                  


Lys Thr Lys His Met Leu Pro Ser Gly Phe Arg Lys Phe Leu Val His 
65                  70                  75                  80  


Asn Val Lys Glu Leu Glu Val Leu Leu Met Cys Asn Lys Ser Tyr Cys 
                85                  90                  95      


Ala Glu Ile Ala His Asn Val Ser Ser Lys Asn Arg Lys Ala Ile Val 
            100                 105                 110         


Glu Arg Ala Ala Gln Leu Ala Ile Arg Val Thr Asn Pro Asn Ala Arg 
        115                 120                 125             


Leu Arg Ser Glu Glu Asn Glu 
    130                 135 


<210>  110
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ser Gly Arg Leu Trp Ser Lys Ala Ile Phe Ala Gly Tyr Lys Arg 
1               5                   10                  15      


Gly Leu Arg Asn Gln Arg Glu His Thr Ala Leu Leu Lys Ile Glu Gly 
            20                  25                  30          


Val Tyr Ala Arg Asp Glu Thr Glu Phe Tyr Leu Gly Lys Arg Cys Ala 
        35                  40                  45              


Tyr Val Tyr Lys Ala Lys Asn Asn Thr Val Thr Pro Gly Gly Lys Pro 
    50                  55                  60                  


Asn Lys Thr Arg Val Ile Trp Gly Lys Val Thr Arg Ala His Gly Asn 
65                  70                  75                  80  


Ser Gly Met Val Arg Ala Lys Phe Arg Ser Asn Leu Pro Ala Lys Ala 
                85                  90                  95      


Ile Gly His Arg Ile Arg Val Met Leu Tyr Pro Ser Arg Ile 
            100                 105                 110 


<210>  111
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Val Asn Val Pro Lys Thr Arg Arg Thr Phe Cys Lys Lys Cys Gly 
1               5                   10                  15      


Lys His Gln Pro His Lys Val Thr Gln Tyr Lys Lys Gly Lys Asp Ser 
            20                  25                  30          


Leu Tyr Ala Gln Gly Arg Arg Arg Tyr Asp Arg Lys Gln Ser Gly Tyr 
        35                  40                  45              


Gly Gly Gln Thr Lys Pro Ile Phe Arg Lys Lys Ala Lys Thr Thr Lys 
    50                  55                  60                  


Lys Ile Val Leu Arg Leu Glu Cys Val Glu Pro Asn Cys Arg Ser Lys 
65                  70                  75                  80  


Arg Met Leu Ala Ile Lys Arg Cys Lys His Phe Glu Leu Gly Gly Asp 
                85                  90                  95      


Lys Lys Arg Lys Gly Gln Val Ile Gln Phe 
            100                 105     


<210>  112
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ala Lys Arg Thr Lys Lys Val Gly Ile Val Gly Lys Tyr Gly Thr 
1               5                   10                  15      


Arg Tyr Gly Ala Ser Leu Arg Lys Met Val Lys Lys Ile Glu Ile Ser 
            20                  25                  30          


Gln His Ala Lys Tyr Thr Cys Ser Phe Cys Gly Lys Thr Lys Met Lys 
        35                  40                  45              


Arg Arg Ala Val Gly Ile Trp His Cys Gly Ser Cys Met Lys Thr Val 
    50                  55                  60                  


Ala Gly Gly Ala Trp Thr Tyr Asn Thr Thr Ser Ala Val Thr Val Lys 
65                  70                  75                  80  


Ser Ala Ile Arg Arg Leu Lys Glu Leu Lys Asp Gln 
                85                  90          


<210>  113
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ser Ser His Lys Thr Phe Arg Ile Lys Arg Phe Leu Ala Lys Lys 
1               5                   10                  15      


Gln Lys Gln Asn Arg Pro Ile Pro Gln Trp Ile Arg Met Lys Thr Gly 
            20                  25                  30          


Asn Lys Ile Arg Tyr Asn Ser Lys Arg Arg His Trp Arg Arg Thr Lys 
        35                  40                  45              


Leu Gly Leu 
    50      


<210>  114
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Ser Val Ser Glu Leu Ala Cys Ile Tyr Ser Ala Leu Ile Leu 
1               5                   10                  15      


His Asp Asp Glu Val Thr Val Thr Glu Asp Lys Ile Asn Ala Leu Ile 
            20                  25                  30          


Lys Ala Ala Gly Val Asn Val Glu Pro Phe Trp Pro Gly Leu Phe Ala 
        35                  40                  45              


Lys Ala Leu Ala Asn Val Asn Ile Gly Ser Leu Ile Cys Asn Val Gly 
    50                  55                  60                  


Ala Gly Gly Pro Ala Pro Ala Ala Gly Ala Ala Pro Ala Gly Gly Pro 
65                  70                  75                  80  


Ala Pro Ser Thr Ala Ala Ala Pro Ala Glu Glu Lys Lys Val Glu Ala 
                85                  90                  95      


Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly Leu 
            100                 105                 110         


Phe Asp 
        


<210>  115
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Leu Pro Ala Ala Ala Arg Pro Leu Trp Gly Pro Cys Leu Gly Leu 
1               5                   10                  15      


Arg Ala Ala Ala Phe Arg Leu Ala Arg Arg Gln Val Pro Cys Val Cys 
            20                  25                  30          


Ala Val Arg His Met Arg Ser Ser Gly His Gln Arg Cys Glu Ala Leu 
        35                  40                  45              


Ala Gly Ala Pro Leu Asp Asn Ala Pro Lys Glu Tyr Pro Pro Lys Ile 
    50                  55                  60                  


Gln Gln Leu Val Gln Asp Ile Ala Ser Leu Thr Leu Leu Glu Ile Ser 
65                  70                  75                  80  


Asp Leu Asn Glu Leu Leu Lys Lys Thr Leu Lys Ile Gln Asp Val Gly 
                85                  90                  95      


Leu Val Pro Met Gly Gly Val Met Ser Gly Ala Val Pro Ala Ala Ala 
            100                 105                 110         


Ala Gln Glu Ala Val Glu Glu Asp Ile Pro Ile Ala Lys Glu Arg Thr 
        115                 120                 125             


His Phe Thr Val Arg Leu Thr Glu Ala Lys Pro Val Asp Lys Val Lys 
    130                 135                 140                 


Leu Ile Lys Glu Ile Lys Asn Tyr Ile Gln Gly Ile Asn Leu Val Gln 
145                 150                 155                 160 


Ala Lys Lys Leu Val Glu Ser Leu Pro Gln Glu Ile Lys Ala Asn Val 
                165                 170                 175     


Ala Lys Ala Glu Ala Glu Lys Ile Lys Ala Ala Leu Glu Ala Val Gly 
            180                 185                 190         


Gly Thr Val Val Leu Glu 
        195             


<210>  116
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Lys Leu Asn Ile Ser Phe Pro Ala Thr Gly Cys Gln Lys Leu Ile 
1               5                   10                  15      


Glu Val Asp Asp Glu Arg Lys Leu Arg Thr Phe Tyr Glu Lys Arg Met 
            20                  25                  30          


Ala Thr Glu Val Ala Ala Asp Ala Leu Gly Glu Glu Trp Lys Gly Tyr 
        35                  40                  45              


Val Val Arg Ile Ser Gly Gly Asn Asp Lys Gln Gly Phe Pro Met Lys 
    50                  55                  60                  


Gln Gly Val Leu Thr His Gly Arg Val Arg Leu Leu Leu Ser Lys Gly 
65                  70                  75                  80  


His Ser Cys Tyr Arg Pro Arg Arg Thr Gly Glu Arg Lys Arg Lys Ser 
                85                  90                  95      


Val Arg Gly Cys Ile Val Asp Ala Asn Leu Ser Val Leu Asn Leu Val 
            100                 105                 110         


Ile Val Lys Lys Gly Glu Lys Asp Ile Pro Gly Leu Thr Asp Thr Thr 
        115                 120                 125             


Val Pro Arg Arg Leu Gly Pro Lys Arg Ala Ser Arg Ile Arg Lys Leu 
    130                 135                 140                 


Phe Asn Leu Ser Lys Glu Asp Asp Val Arg Gln Tyr Val Val Arg Lys 
145                 150                 155                 160 


Pro Leu Asn Lys Glu Gly Lys Lys Pro Arg Thr Lys Ala Pro Lys Ile 
                165                 170                 175     


Gln Arg Leu Val Thr Pro Arg Val Leu Gln His Lys Arg Arg Arg Ile 
            180                 185                 190         


Ala Leu Lys Lys Gln Arg Thr Lys Lys Asn Lys Glu Glu Ala Ala Glu 
        195                 200                 205             


Tyr Ala Lys Leu Leu Ala Lys Arg Met Lys Glu Ala Lys Glu Lys Arg 
    210                 215                 220                 


Gln Glu Gln Ile Ala Lys Arg Arg Arg Leu Ser Ser Leu Arg Ala Ser 
225                 230                 235                 240 


Thr Ser Lys Ser Glu Ser Ser Gln Lys 
                245                 


<210>  117
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly 
1               5                   10                  15      


Lys Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro 
            20                  25                  30          


Ala Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val 
        35                  40                  45              


Arg Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn 
    50                  55                  60                  


Phe Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp 
65                  70                  75                  80  


Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu 
                85                  90                  95      


Val Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp 
            100                 105                 110         


Tyr Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys 
        115                 120                 125             


Leu Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser 
145                 150                 155                 160 


Leu Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala 
                165                 170                 175     


Ser Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly 
            180                 185                 190         


Lys Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys 
        195                 200                 205             


<210>  118
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Leu Met Pro Lys Lys Asn Arg Ile Ala Ile Tyr Glu Leu Leu Phe 
1               5                   10                  15      


Lys Glu Gly Val Met Val Ala Lys Lys Asp Val His Met Pro Lys His 
            20                  25                  30          


Pro Glu Leu Ala Asp Lys Asn Val Pro Asn Leu His Val Met Lys Ala 
        35                  40                  45              


Met Gln Ser Leu Lys Ser Arg Gly Tyr Val Lys Glu Gln Phe Ala Trp 
    50                  55                  60                  


Arg His Phe Tyr Trp Tyr Leu Thr Asn Glu Gly Ile Gln Tyr Leu Arg 
65                  70                  75                  80  


Asp Tyr Leu His Leu Pro Pro Glu Ile Val Pro Ala Thr Leu Arg Arg 
                85                  90                  95      


Ser Arg Pro Glu Thr Gly Arg Pro Arg Pro Lys Gly Leu Glu Gly Glu 
            100                 105                 110         


Arg Pro Ala Arg Leu Thr Arg Gly Glu Ala Asp Arg Asp Thr Tyr Arg 
        115                 120                 125             


Arg Ser Ala Val Pro Pro Gly Ala Asp Lys Lys Ala Glu Ala Gly Ala 
    130                 135                 140                 


Gly Ser Ala Thr Glu Phe Gln Phe Arg Gly Gly Phe Gly Arg Gly Arg 
145                 150                 155                 160 


Gly Gln Pro Pro Gln 
                165 


<210>  119
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ala Glu Glu Gly Ile Ala Ala Gly Gly Val Met Asp Val Asn Thr 
1               5                   10                  15      


Ala Leu Gln Glu Val Leu Lys Thr Ala Leu Ile His Asp Gly Leu Ala 
            20                  25                  30          


Arg Gly Ile Arg Glu Ala Ala Lys Ala Leu Asp Lys Arg Gln Ala His 
        35                  40                  45              


Leu Cys Val Leu Ala Ser Asn Cys Asp Glu Pro Met Tyr Val Lys Leu 
    50                  55                  60                  


Val Glu Ala Leu Cys Ala Glu His Gln Ile Asn Leu Ile Lys Val Asp 
65                  70                  75                  80  


Asp Asn Lys Lys Leu Gly Glu Trp Val Gly Leu Cys Lys Ile Asp Arg 
                85                  90                  95      


Glu Gly Lys Pro Arg Lys Val Val Gly Cys Ser Cys Val Val Val Lys 
            100                 105                 110         


Asp Tyr Gly Lys Glu Ser Gln Ala Lys Asp Val Ile Glu Glu Tyr Phe 
        115                 120                 125             


Lys Cys Lys Lys 
    130         


<210>  120
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Val Arg Met Asn Val Leu Ala Asp Ala Leu Lys Ser Ile Asn Asn 
1               5                   10                  15      


Ala Glu Lys Arg Gly Lys Arg Gln Val Leu Ile Arg Pro Cys Ser Lys 
            20                  25                  30          


Val Ile Val Arg Phe Leu Thr Val Met Met Lys His Gly Tyr Ile Gly 
        35                  40                  45              


Glu Phe Glu Ile Ile Asp Asp His Arg Ala Gly Lys Ile Val Val Asn 
    50                  55                  60                  


Leu Thr Gly Arg Leu Asn Lys Cys Gly Val Ile Ser Pro Arg Phe Asp 
65                  70                  75                  80  


Val Gln Leu Lys Asp Leu Glu Lys Trp Gln Asn Asn Leu Leu Pro Ser 
                85                  90                  95      


Arg Gln Phe Gly Phe Ile Val Leu Thr Thr Ser Ala Gly Ile Met Asp 
            100                 105                 110         


His Glu Glu Ala Arg Arg Lys His Thr Gly Gly Lys Ile Leu Gly Phe 
        115                 120                 125             


Phe Phe 
    130 


<210>  121
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Pro Gly Val Thr Val Lys Asp Val Asn Gln Gln Glu Phe Val Arg 
1               5                   10                  15      


Ala Leu Ala Ala Phe Leu Lys Lys Ser Gly Lys Leu Lys Val Pro Glu 
            20                  25                  30          


Trp Val Asp Thr Val Lys Leu Ala Lys His Lys Glu Leu Ala Pro Tyr 
        35                  40                  45              


Asp Glu Asn Trp Phe Tyr Thr Arg Ala Ala Ser Thr Ala Arg His Leu 
    50                  55                  60                  


Tyr Leu Arg Gly Gly Ala Gly Val Gly Ser Met Thr Lys Ile Tyr Gly 
65                  70                  75                  80  


Gly Arg Gln Arg Asn Gly Val Met Pro Ser His Phe Ser Arg Gly Ser 
                85                  90                  95      


Lys Ser Val Ala Arg Arg Val Leu Gln Ala Leu Glu Gly Leu Lys Met 
            100                 105                 110         


Val Glu Lys Asp Gln Asp Gly Gly Arg Lys Leu Thr Pro Gln Gly Gln 
        115                 120                 125             


Arg Asp Leu Asp Arg Ile Ala Gly Gln Val Ala Ala Ala Asn Lys Lys 
    130                 135                 140                 


His 
145 


<210>  122
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gln Asn Asp Ala Gly Glu Phe Val Asp Leu Tyr Val Pro Arg Lys 
1               5                   10                  15      


Cys Ser Ala Ser Asn Arg Ile Ile Gly Ala Lys Asp His Ala Ser Ile 
            20                  25                  30          


Gln Met Asn Val Ala Glu Val Asp Lys Val Thr Gly Arg Phe Asn Gly 
        35                  40                  45              


Gln Phe Lys Thr Tyr Ala Ile Cys Gly Ala Ile Arg Arg Met Gly Glu 
    50                  55                  60                  


Ser Asp Asp Ser Ile Leu Arg Leu Ala Lys Ala Asp Gly Ile Val Ser 
65                  70                  75                  80  


Lys Asn Phe 
            


<210>  123
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Pro Pro Lys Asp Asp Lys Lys Lys Lys Asp Ala Gly Lys Ser Ala 
1               5                   10                  15      


Lys Lys Asp Lys Asp Pro Val Asn Lys Ser Gly Gly Lys Ala Lys Lys 
            20                  25                  30          


Lys Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn Asn Leu Val 
        35                  40                  45              


Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro Asn 
    50                  55                  60                  


Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys Ile Arg 
65                  70                  75                  80  


Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser Lys Gly Leu 
                85                  90                  95      


Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr Thr Arg Asn 
            100                 105                 110         


Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala 
        115                 120                 125 


<210>  124
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Asp Thr Ser Arg Val Gln Pro Ile Lys Leu Ala Arg Val Thr Lys 
1               5                   10                  15      


Val Leu Gly Arg Thr Gly Ser Gln Gly Gln Cys Thr Gln Val Arg Val 
            20                  25                  30          


Glu Phe Met Asp Asp Thr Ser Arg Ser Ile Ile Arg Asn Val Lys Gly 
        35                  40                  45              


Pro Val Arg Glu Gly Asp Val Leu Thr Leu Leu Glu Ser Glu Arg Glu 
    50                  55                  60                  


Ala Arg Arg Leu Arg 
65                  


<210>  125
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
        115                 120                 125 


<210>  126
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Lys His Leu Lys Phe Ile Ala Arg Thr Val Met Val Gln Glu 
1               5                   10                  15      


Gly Asn Val Glu Ser Ala Tyr Arg Thr Leu Asn Arg Ile Leu Thr Met 
            20                  25                  30          


Asp Gly Leu Ile Glu Asp Ile Lys His Arg Arg Tyr Tyr Glu Lys Pro 
        35                  40                  45              


Cys Arg Arg Arg Gln Arg Glu Ser Tyr Glu Arg Cys Arg Arg Ile Tyr 
    50                  55                  60                  


Asn Met Glu Met Ala Arg Lys Ile Asn Phe Leu Met Arg Lys Asn Arg 
65                  70                  75                  80  


Ala Asp Pro Trp Gln Gly Cys 
                85          


<210>  127
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Val Phe Leu Thr Ala Gln Leu Trp Leu Arg Asn Arg Val Thr Asp 
1               5                   10                  15      


Arg Tyr Phe Arg Ile Gln Glu Val Leu Lys His Ala Arg His Phe Arg 
            20                  25                  30          


Gly Arg Lys Asn Arg Cys Tyr Arg Leu Ala Val Arg Thr Val Ile Arg 
        35                  40                  45              


Ala Phe Val Lys Cys Thr Lys Ala Arg Tyr Leu Lys Lys Lys Asn Met 
    50                  55                  60                  


Arg Thr Leu Trp Ile Asn Arg Ile Thr Ala Ala Ser Gln Glu His Gly 
65                  70                  75                  80  


Leu Lys Tyr Pro Ala Leu Ile Gly Asn Leu Val Lys Cys Gln Val Glu 
                85                  90                  95      


Leu Asn Arg Lys Val Leu Ala Asp Leu Ala Ile Tyr Glu Pro Lys Thr 
            100                 105                 110         


Phe Lys Ser Leu Ala Ala Leu Ala Ser Arg Arg Arg His Glu Gly Phe 
        115                 120                 125             


Ala Ala Ala Leu Gly Asp Gly Lys Glu Pro Glu Gly Ile Phe Ser Arg 
    130                 135                 140                 


Val Val Gln Tyr His 
145                 


<210>  128
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ala Ala Ser Ser Leu Thr Val Thr Leu Gly Arg Leu Ala Ser Ala 
1               5                   10                  15      


Cys Ser His Ser Ile Leu Arg Pro Ser Gly Pro Gly Ala Ala Ser Leu 
            20                  25                  30          


Trp Ser Ala Ser Arg Arg Phe Asn Ser Gln Ser Thr Ser Tyr Leu Pro 
        35                  40                  45              


Gly Tyr Val Pro Lys Thr Ser Leu Ser Ser Pro Pro Trp Pro Glu Val 
    50                  55                  60                  


Val Leu Pro Asp Pro Val Glu Glu Thr Arg His His Ala Glu Val Val 
65                  70                  75                  80  


Lys Lys Val Asn Glu Met Ile Val Thr Gly Gln Tyr Gly Arg Leu Phe 
                85                  90                  95      


Ala Val Val His Phe Ala Ser Arg Gln Trp Lys Val Thr Ser Glu Asp 
            100                 105                 110         


Leu Ile Leu Ile Gly Asn Glu Leu Asp Leu Ala Cys Gly Glu Arg Ile 
        115                 120                 125             


Arg Leu Glu Lys Val Leu Leu Val Gly Ala Asp Asn Phe Thr Leu Leu 
    130                 135                 140                 


Gly Lys Pro Leu Leu Gly Lys Asp Leu Val Arg Val Glu Ala Thr Val 
145                 150                 155                 160 


Ile Glu Lys Thr Glu Ser Trp Pro Arg Ile Ile Met Arg Phe Arg Lys 
                165                 170                 175     


Arg Lys Asn Phe Lys Lys Lys Arg Ile Val Thr Thr Pro Gln Thr Val 
            180                 185                 190         


Leu Arg Ile Asn Ser Ile Glu Ile Ala Pro Cys Leu Leu 
        195                 200                 205 


<210>  129
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Ser Ser Phe Ser Arg Ala Pro Gln Gln Trp Ala Thr Phe Ala Arg 
1               5                   10                  15      


Ile Trp Tyr Leu Leu Asp Gly Lys Met Gln Pro Pro Gly Lys Leu Ala 
            20                  25                  30          


Ala Met Ala Ser Ile Arg Leu Gln Gly Leu His Lys Pro Val Tyr His 
        35                  40                  45              


Ala Leu Ser Asp Cys Gly Asp His Val Val Ile Met Asn Thr Arg His 
    50                  55                  60                  


Ile Ala Phe Ser Gly Asn Lys Trp Glu Gln Lys Val Tyr Ser Ser His 
65                  70                  75                  80  


Thr Gly Tyr Pro Gly Gly Phe Arg Gln Val Thr Ala Ala Gln Leu His 
                85                  90                  95      


Leu Arg Asp Pro Val Ala Ile Val Lys Leu Ala Ile Tyr Gly Met Leu 
            100                 105                 110         


Pro Lys Asn Leu His Arg Arg Thr Met Met Glu Arg Leu His Leu Phe 
        115                 120                 125             


Pro Asp Glu Tyr Ile Pro Glu Asp Ile Leu Lys Asn Leu Val Glu Glu 
    130                 135                 140                 


Leu Pro Gln Pro Arg Lys Ile Pro Lys Arg Leu Asp Glu Tyr Thr Gln 
145                 150                 155                 160 


Glu Glu Ile Asp Ala Phe Pro Arg Leu Trp Thr Pro Pro Glu Asp Tyr 
                165                 170                 175     


Arg Leu 
        


<210>  130
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala His Ser Val Gly Leu Met Trp Trp 
                165                 170                 175     


Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg Glu 
            180                 185                 190         


His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro Glu 
        195                 200                 205             


Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr Lys 
    210                 215                 220                 


Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr Ala 
225                 230                 235                 240 


Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro Ser 
                245                 250                 255     


Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro Ala 
            260                 265                 270         


Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp Val 
        275                 280                 285             


Gly Ala Thr Thr Asp Trp Ser 
    290                 295 


<210>  131
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Val Phe Arg Arg Phe Val Glu Val Gly Arg Val Ala Tyr Val Ser 
1               5                   10                  15      


Phe Gly Pro His Ala Gly Lys Leu Val Ala Ile Val Asp Val Ile Asp 
            20                  25                  30          


Gln Asn Arg Ala Leu Val Asp Gly Pro Cys Thr Gln Val Arg Arg Gln 
        35                  40                  45              


Ala Met Pro Phe Lys Cys Met Gln Leu Thr Asp Phe Ile Leu Lys Phe 
    50                  55                  60                  


Pro His Ser Ala His Gln Lys Tyr Val Arg Gln Ala Trp Gln Lys Ala 
65                  70                  75                  80  


Asp Ile Asn Thr Lys Trp Ala Ala Thr Arg Trp Ala Lys Lys Ile Glu 
                85                  90                  95      


Ala Arg Glu Arg Lys Ala Lys Met Thr Asp Phe Asp Arg Phe Lys Val 
            100                 105                 110         


Met Lys Ala Lys Lys Met Arg Asn Arg Ile Ile Lys Asn Glu Val Lys 
        115                 120                 125             


Lys Leu Gln Lys Ala Ala Leu Leu Lys Ala Ser Pro Lys Lys Ala Pro 
    130                 135                 140                 


Gly Thr Lys Gly Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys 
145                 150                 155                 160 


Val Pro Ala Lys Lys Ile Thr Ala Ala Ser Lys Lys Ala Pro Ala Gln 
                165                 170                 175     


Lys Val Pro Ala Gln Lys Ala Thr Gly Gln Lys Ala Ala Pro Ala Pro 
            180                 185                 190         


Lys Ala Gln Lys Gly Gln Lys Ala Pro Ala Gln Lys Ala Pro Ala Pro 
        195                 200                 205             


Lys Ala Ser Gly Lys Lys Ala 
    210                 215 


<210>  132
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Ala Leu Lys Ala Leu Val Ser Gly Cys Gly Arg Leu Leu Arg 
1               5                   10                  15      


Gly Leu Leu Ala Gly Pro Ala Ala Thr Ser Trp Ser Arg Leu Pro Ala 
            20                  25                  30          


Arg Gly Phe Arg Glu Val Val Glu Thr Gln Glu Gly Lys Thr Thr Ile 
        35                  40                  45              


Ile Glu Gly Arg Ile Thr Ala Thr Pro Lys Glu Ser Pro Asn Pro Pro 
    50                  55                  60                  


Asn Pro Ser Gly Gln Cys Pro Ile Cys Arg Trp Asn Leu Lys His Lys 
65                  70                  75                  80  


Tyr Asn Tyr Asp Asp Val Leu Leu Leu Ser Gln Phe Ile Arg Pro His 
                85                  90                  95      


Gly Gly Met Leu Pro Arg Lys Ile Thr Gly Leu Cys Gln Glu Glu His 
            100                 105                 110         


Arg Lys Ile Glu Glu Cys Val Lys Met Ala His Arg Ala Gly Leu Leu 
        115                 120                 125             


Pro Asn His Arg Pro Arg Leu Pro Glu Gly Val Val Pro Lys Ser Lys 
    130                 135                 140                 


Pro Gln Leu Asn Arg Tyr Leu Thr Arg Trp Ala Pro Gly Ser Val Lys 
145                 150                 155                 160 


Pro Ile Tyr Lys Lys Gly Pro Arg Trp Asn Arg Val Arg Met Pro Val 
                165                 170                 175     


Gly Ser Pro Leu Leu Arg Asp Asn Val Cys Tyr Ser Arg Thr Pro Trp 
            180                 185                 190         


Lys Leu Tyr His 
        195     


<210>  133
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Leu Gln Phe Val Arg Ala Gly Ala Arg Ala Trp Leu Arg Pro Thr 
1               5                   10                  15      


Gly Ser Gln Gly Leu Ser Ser Leu Ala Glu Glu Ala Ala Arg Ala Thr 
            20                  25                  30          


Glu Asn Pro Glu Gln Val Ala Ser Glu Gly Leu Pro Glu Pro Val Leu 
        35                  40                  45              


Arg Lys Val Glu Leu Pro Val Pro Thr His Arg Arg Pro Val Gln Ala 
    50                  55                  60                  


Trp Val Glu Ser Leu Arg Gly Phe Glu Gln Glu Arg Val Gly Leu Ala 
65                  70                  75                  80  


Asp Leu His Pro Asp Val Phe Ala Thr Ala Pro Arg Leu Asp Ile Leu 
                85                  90                  95      


His Gln Val Ala Met Trp Gln Lys Asn Phe Lys Arg Ile Ser Tyr Ala 
            100                 105                 110         


Lys Thr Lys Thr Arg Ala Glu Val Arg Gly Gly Gly Arg Lys Pro Trp 
        115                 120                 125             


Pro Gln Lys Gly Thr Gly Arg Ala Arg His Gly Ser Ile Arg Ser Pro 
    130                 135                 140                 


Leu Trp Arg Gly Gly Gly Val Ala His Gly Pro Arg Gly Pro Thr Ser 
145                 150                 155                 160 


Tyr Tyr Tyr Met Leu Pro Met Lys Val Arg Ala Leu Gly Leu Lys Val 
                165                 170                 175     


Ala Leu Thr Val Lys Leu Ala Gln Asp Asp Leu His Ile Met Asp Ser 
            180                 185                 190         


Leu Glu Leu Pro Thr Gly Asp Pro Gln Tyr Leu Thr Glu Leu Ala His 
        195                 200                 205             


Tyr Arg Arg Trp Gly Asp Ser Val Leu Leu Val Asp Leu Thr His Glu 
    210                 215                 220                 


Glu Met Pro Gln Ser Ile Val Glu Ala Thr Ser Arg Leu Lys Thr Phe 
225                 230                 235                 240 


Asn Leu Ile Pro Ala Val Gly Leu Asn Val His Ser Met Leu Lys His 
                245                 250                 255     


Gln Thr Leu Val Leu Thr Leu Pro Thr Val Ala Phe Leu Glu Asp Lys 
            260                 265                 270         


Leu Leu Trp Gln Asp Ser Arg Tyr Arg Pro Leu Tyr Pro Phe Ser Leu 
        275                 280                 285             


Pro Tyr Ser Asp Phe Pro Arg Pro Leu Pro His Ala Thr Gln Gly Pro 
    290                 295                 300                 


Ala Ala Thr Pro Tyr His Cys 
305                 310     


<210>  134
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Ala Asn Leu Phe Ile Arg Lys Met Val Asn Pro Leu Leu Tyr Leu 
1               5                   10                  15      


Ser Arg His Thr Val Lys Pro Arg Ala Leu Ser Thr Phe Leu Phe Gly 
            20                  25                  30          


Ser Ile Arg Gly Ala Ala Pro Val Ala Val Glu Pro Gly Ala Ala Val 
        35                  40                  45              


Arg Ser Leu Leu Ser Pro Gly Leu Leu Pro His Leu Leu Pro Ala Leu 
    50                  55                  60                  


Gly Phe Lys Asn Lys Thr Val Leu Lys Lys Arg Cys Lys Asp Cys Tyr 
65                  70                  75                  80  


Leu Val Lys Arg Arg Gly Arg Trp Tyr Val Tyr Cys Lys Thr His Pro 
                85                  90                  95      


Arg His Lys Gln Arg Gln Met 
            100             


<210>  135
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Gly Phe Val Lys Val Val Lys Asn Lys Ala Tyr Phe Lys Arg Tyr 
1               5                   10                  15      


Gln Val Lys Phe Arg Arg Arg Arg Glu Gly Lys Thr Asp Tyr Tyr Ala 
            20                  25                  30          


Arg Lys Arg Leu Val Ile Gln Asp Lys Asn Lys Tyr Asn Thr Pro Lys 
        35                  40                  45              


Tyr Arg Met Ile Val Arg Val Thr Asn Arg Asp Ile Ile Cys Gln Ile 
    50                  55                  60                  


Ala Tyr Ala Arg Ile Glu Gly Asp Met Ile Val Cys Ala Ala Tyr Ala 
65                  70                  75                  80  


His Glu Leu Pro Lys Tyr Gly Val Lys Val Gly Leu Thr Asn Tyr Ala 
                85                  90                  95      


Ala Ala Tyr Cys Thr Gly Leu Leu Leu Ala Arg Arg Leu Leu Asn Arg 
            100                 105                 110         


Phe Gly Met Asp Lys Ile Tyr Glu Gly Gln Val Glu Val Thr Gly Asp 
        115                 120                 125             


Glu Tyr Asn Val Glu Ser Ile Asp Gly Gln Pro Gly Ala Phe Thr Cys 
    130                 135                 140                 


Tyr Leu Asp Ala Gly Leu Ala Arg Thr Thr Thr Gly Asn Lys Val Phe 
145                 150                 155                 160 


Gly Ala Leu Lys Gly Ala Val Asp Gly Gly Leu Ser Ile Pro His Ser 
                165                 170                 175     


Thr Lys Arg Phe Pro Gly Tyr Asp Ser Glu Ser Lys Glu Phe Asn Ala 
            180                 185                 190         


Glu Val His Arg Lys His Ile Met Gly Gln Asn Val Ala Asp Tyr Met 
        195                 200                 205             


Arg Tyr Leu Met Glu Glu Asp Glu Asp Ala Tyr Lys Lys Gln Phe Ser 
    210                 215                 220                 


Gln Tyr Ile Lys Asn Ser Val Thr Pro Asp Met Met Glu Glu Met Tyr 
225                 230                 235                 240 


Lys Lys Ala His Ala Ala Ile Arg Glu Asn Pro Val Tyr Glu Lys Lys 
                245                 250                 255     


Pro Lys Lys Glu Val Lys Lys Lys Arg Trp Asn Arg Pro Lys Met Ser 
            260                 265                 270         


Leu Ala Gln Lys Lys Asp Arg Val Ala Gln Lys Lys Ala Ser Phe Leu 
        275                 280                 285             


Arg Ala Gln Glu Arg Ala Ala Glu Ser 
    290                 295         


<210>  136
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Glu Gly Val Glu Glu Lys Lys Lys Glu Val Pro Ala Val Pro Glu 
1               5                   10                  15      


Thr Leu Lys Lys Lys Arg Arg Asn Phe Ala Glu Leu Lys Ile Lys Arg 
            20                  25                  30          


Leu Arg Lys Lys Phe Ala Gln Lys Met Leu Arg Lys Ala Arg Arg Lys 
        35                  40                  45              


Leu Ile Tyr Glu Lys Ala Lys His Tyr His Lys Glu Tyr Arg Gln Met 
    50                  55                  60                  


Tyr Arg Thr Glu Ile Arg Met Ala Arg Met Ala Arg Lys Ala Gly Asn 
65                  70                  75                  80  


Phe Tyr Val Pro Ala Glu Pro Lys Leu Ala Phe Val Ile Arg Ile Arg 
                85                  90                  95      


Gly Ile Asn Gly Val Ser Pro Lys Val Arg Lys Val Leu Gln Leu Leu 
            100                 105                 110         


Arg Leu Arg Gln Ile Phe Asn Gly Thr Phe Val Lys Leu Asn Lys Ala 
        115                 120                 125             


Ser Ile Asn Met Leu Arg Ile Val Glu Pro Tyr Ile Ala Trp Gly Tyr 
    130                 135                 140                 


Pro Asn Leu Lys Ser Val Asn Glu Leu Ile Tyr Lys Arg Gly Tyr Gly 
145                 150                 155                 160 


Lys Ile Asn Lys Lys Arg Ile Ala Leu Thr Asp Asn Ala Leu Ile Ala 
                165                 170                 175     


Arg Ser Leu Gly Lys Tyr Gly Ile Ile Cys Met Glu Asp Leu Ile His 
            180                 185                 190         


Glu Ile Tyr Thr Val Gly Lys Arg Phe Lys Glu Ala Asn Asn Phe Leu 
        195                 200                 205             


Trp Pro Phe Lys Leu Ser Ser Pro Arg Gly Gly Met Lys Lys Lys Thr 
    210                 215                 220                 


Thr His Phe Val Glu Gly Gly Asp Ala Gly Asn Arg Glu Asp Gln Ile 
225                 230                 235                 240 


Asn Arg Leu Ile Arg Arg Met Asn 
                245             


<210>  137
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Glu Asn Arg Glu Pro Arg Gly Ala Val Glu Ala Glu Leu Asp 
1               5                   10                  15      


Pro Val Glu Tyr Thr Leu Arg Lys Arg Leu Pro Ser Arg Leu Pro Arg 
            20                  25                  30          


Arg Pro Asn Asp Ile Tyr Val Asn Met Lys Thr Asp Phe Lys Ala Gln 
        35                  40                  45              


Leu Ala Arg Cys Gln Lys Leu Leu Asp Gly Gly Ala Arg Gly Gln Asn 
    50                  55                  60                  


Ala Cys Ser Glu Ile Tyr Ile His Gly Leu Gly Leu Ala Ile Asn Arg 
65                  70                  75                  80  


Ala Ile Asn Ile Ala Leu Gln Leu Gln Ala Gly Ser Phe Gly Ser Leu 
                85                  90                  95      


Gln Val Ala Ala Asn Thr Ser Thr Val Glu Leu Val Asp Glu Leu Glu 
            100                 105                 110         


Pro Glu Thr Asp Thr Arg Glu Pro Leu Thr Arg Ile Arg Asn Asn Ser 
        115                 120                 125             


Ala Ile His Ile Arg Val Phe Arg Val Thr Pro Lys 
    130                 135                 140 


<210>  138
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Phe Val Ala Arg Ser Ile Ala Ala Asp His Lys Asp Leu Ile His 
1               5                   10                  15      


Asp Val Ser Phe Asp Phe His Gly Arg Arg Met Ala Thr Cys Ser Ser 
            20                  25                  30          


Asp Gln Ser Val Lys Val Trp Asp Lys Ser Glu Ser Gly Asp Trp His 
        35                  40                  45              


Cys Thr Ala Ser Trp Lys Thr His Ser Gly Ser Val Trp Arg Val Thr 
    50                  55                  60                  


Trp Ala His Pro Glu Phe Gly Gln Val Leu Ala Ser Cys Ser Phe Asp 
65                  70                  75                  80  


Arg Thr Ala Ala Val Trp Glu Glu Ile Val Gly Glu Ser Asn Asp Lys 
                85                  90                  95      


Leu Arg Gly Gln Ser His Trp Val Lys Arg Thr Thr Leu Val Asp Ser 
            100                 105                 110         


Arg Thr Ser Val Thr Asp Val Lys Phe Ala Pro Lys His Met Gly Leu 
        115                 120                 125             


Met Leu Ala Thr Cys Ser Ala Asp Gly Ile Val Arg Ile Tyr Glu Ala 
    130                 135                 140                 


Pro Asp Val Met Asn Leu Ser Gln Trp Ser Leu Gln His Glu Ile Ser 
145                 150                 155                 160 


Cys Lys Leu Ser Cys Ser Cys Ile Ser Trp Asn Pro Ser Ser Ser Arg 
                165                 170                 175     


Ala His Ser Pro Met Ile Ala Val Gly Ser Asp Asp Ser Ser Pro Asn 
            180                 185                 190         


Ala Met Ala Lys Val Gln Ile Phe Glu Tyr Asn Glu Asn Thr Arg Lys 
        195                 200                 205             


Tyr Ala Lys Ala Glu Thr Leu Met Thr Val Thr Asp Pro Val His Asp 
    210                 215                 220                 


Ile Ala Phe Ala Pro Asn Leu Gly Arg Ser Phe His Ile Leu Ala Ile 
225                 230                 235                 240 


Ala Thr Lys Asp Val Arg Ile Phe Thr Leu Lys Pro Val Arg Lys Glu 
                245                 250                 255     


Leu Thr Ser Ser Gly Gly Pro Thr Lys Phe Glu Ile His Ile Val Ala 
            260                 265                 270         


Gln Phe Asp Asn His Asn Ser Gln Val Trp Arg Val Ser Trp Asn Ile 
        275                 280                 285             


Thr Gly Thr Val Leu Ala Ser Ser Gly Asp Asp Gly Cys Val Arg Leu 
    290                 295                 300                 


Trp Lys Ala Asn Tyr Met Asp Asn Trp Lys Cys Thr Gly Ile Leu Lys 
305                 310                 315                 320 


Gly Asn Gly Ser Pro Val Asn Gly Ser Ser Gln Gln Gly Thr Ser Asn 
                325                 330                 335     


Pro Ser Leu Gly Ser Thr Ile Pro Ser Leu Gln Asn Ser Leu Asn Gly 
            340                 345                 350         


Ser Ser Ala Gly Arg Lys His Ser 
        355                 360 


<210>  139
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Lys Ser Val Ile Tyr His Ala Leu Ser Gln Lys Glu Ala Asn Asp 
1               5                   10                  15      


Ser Asp Val Gln Pro Ser Gly Ala Gln Arg Ala Glu Ala Phe Val Arg 
            20                  25                  30          


Ala Phe Leu Lys Arg Ser Thr Pro Arg Met Ser Pro Gln Ala Arg Glu 
        35                  40                  45              


Asp Gln Leu Gln Arg Lys Ala Val Val Leu Glu Tyr Phe Thr Arg His 
    50                  55                  60                  


Lys Arg Lys Glu Lys Lys Lys Lys Ala Lys Gly Leu Ser Ala Arg Gln 
65                  70                  75                  80  


Arg Arg Glu Leu Arg Leu Phe Asp Ile Lys Pro Glu Gln Gln Arg Tyr 
                85                  90                  95      


Ser Leu Phe Leu Pro Leu His Glu Leu Trp Lys Gln Tyr Ile Arg Asp 
            100                 105                 110         


Leu Cys Ser Gly Leu Lys Pro Asp Thr Gln Pro Gln Met Ile Gln Ala 
        115                 120                 125             


Lys Leu Leu Lys Ala Asp Leu His Gly Ala Ile Ile Ser Val Thr Lys 
    130                 135                 140                 


Ser Lys Cys Pro Ser Tyr Val Gly Ile Thr Gly Ile Leu Leu Gln Glu 
145                 150                 155                 160 


Thr Lys His Ile Phe Lys Ile Ile Thr Lys Glu Asp Arg Leu Lys Val 
                165                 170                 175     


Ile Pro Lys Leu Asn Cys Val Phe Thr Val Glu Thr Asp Gly Phe Ile 
            180                 185                 190         


Ser Tyr Ile Tyr Gly Ser Lys Phe Gln Leu Arg Ser Ser Glu Arg Ser 
        195                 200                 205             


Ala Lys Lys Phe Lys Ala Lys Gly Thr Ile Asp Leu 
    210                 215                 220 


<210>  140
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Gly Pro Val Lys Asp Arg Glu Ala Phe Gln Arg Leu Asn Phe 
1               5                   10                  15      


Leu Tyr Gln Ala Ala His Cys Val Leu Ala Gln Asp Pro Glu Asn Gln 
            20                  25                  30          


Ala Leu Ala Arg Phe Tyr Cys Tyr Thr Glu Arg Thr Ile Ala Lys Arg 
        35                  40                  45              


Leu Val Leu Arg Arg Asp Pro Ser Val Lys Arg Thr Leu Cys Arg Gly 
    50                  55                  60                  


Cys Ser Ser Leu Leu Val Pro Gly Leu Thr Cys Thr Gln Arg Gln Arg 
65                  70                  75                  80  


Arg Cys Arg Gly Gln Arg Trp Thr Val Gln Thr Cys Leu Thr Cys Gln 
                85                  90                  95      


Arg Ser Gln Arg Phe Leu Asn Asp Pro Gly His Leu Leu Trp Gly Asp 
            100                 105                 110         


Arg Pro Glu Ala Gln Leu Gly Ser Gln Ala Asp Ser Lys Pro Leu Gln 
        115                 120                 125             


Pro Leu Pro Asn Thr Ala His Ser Ile Ser Asp Arg Leu Pro Glu Glu 
    130                 135                 140                 


Lys Met Gln Thr Gln Gly Ser Ser Asn Gln 
145                 150                 


<210>  141
<211>  790
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Ser Arg Arg Arg His Ser Asp Glu Asn Asp Gly Gly Gln Pro His 
1               5                   10                  15      


Lys Arg Arg Lys Thr Ser Asp Ala Asn Glu Thr Glu Asp His Leu Glu 
            20                  25                  30          


Ser Leu Ile Cys Lys Val Gly Glu Lys Ser Ala Cys Ser Leu Glu Ser 
        35                  40                  45              


Asn Leu Glu Gly Leu Ala Gly Val Leu Glu Ala Asp Leu Pro Asn Tyr 
    50                  55                  60                  


Lys Ser Lys Ile Leu Arg Leu Leu Cys Thr Val Ala Arg Leu Leu Pro 
65                  70                  75                  80  


Glu Lys Leu Thr Ile Tyr Thr Thr Leu Val Gly Leu Leu Asn Ala Arg 
                85                  90                  95      


Asn Tyr Asn Phe Gly Gly Glu Phe Val Glu Ala Met Ile Arg Gln Leu 
            100                 105                 110         


Lys Glu Ser Leu Lys Ala Asn Asn Tyr Asn Glu Ala Val Tyr Leu Val 
        115                 120                 125             


Arg Phe Leu Ser Asp Leu Val Asn Cys His Val Ile Ala Ala Pro Ser 
    130                 135                 140                 


Met Val Ala Met Phe Glu Asn Phe Val Ser Val Thr Gln Glu Glu Asp 
145                 150                 155                 160 


Val Pro Gln Val Arg Arg Asp Trp Tyr Val Tyr Ala Phe Leu Ser Ser 
                165                 170                 175     


Leu Pro Trp Val Gly Lys Glu Leu Tyr Glu Lys Lys Asp Ala Glu Met 
            180                 185                 190         


Asp Arg Ile Phe Ala Asn Thr Glu Ser Tyr Leu Lys Arg Arg Gln Lys 
        195                 200                 205             


Thr His Val Pro Met Leu Gln Val Trp Thr Ala Asp Lys Pro His Pro 
    210                 215                 220                 


Gln Glu Glu Tyr Leu Asp Cys Leu Trp Ala Gln Ile Gln Lys Leu Lys 
225                 230                 235                 240 


Lys Asp Arg Trp Gln Glu Arg His Ile Leu Arg Pro Tyr Leu Ala Phe 
                245                 250                 255     


Asp Ser Ile Leu Cys Glu Ala Leu Gln His Asn Leu Pro Pro Phe Thr 
            260                 265                 270         


Pro Pro Pro His Thr Glu Asp Ser Val Tyr Pro Met Pro Arg Val Ile 
        275                 280                 285             


Phe Arg Met Phe Asp Tyr Thr Asp Asp Pro Glu Gly Pro Val Met Pro 
    290                 295                 300                 


Gly Ser His Ser Val Glu Arg Phe Val Ile Glu Glu Asn Leu His Cys 
305                 310                 315                 320 


Ile Ile Lys Ser His Trp Lys Glu Arg Lys Thr Cys Ala Ala Gln Leu 
                325                 330                 335     


Val Ser Tyr Pro Gly Lys Asn Lys Ile Pro Leu Asn Tyr His Ile Val 
            340                 345                 350         


Glu Val Ile Phe Ala Glu Leu Phe Gln Leu Pro Ala Pro Pro His Ile 
        355                 360                 365             


Asp Val Met Tyr Thr Thr Leu Leu Ile Glu Leu Cys Lys Leu Gln Pro 
    370                 375                 380                 


Gly Ser Leu Pro Gln Val Leu Ala Gln Ala Thr Glu Met Leu Tyr Met 
385                 390                 395                 400 


Arg Leu Asp Thr Met Asn Thr Thr Cys Val Asp Arg Phe Ile Asn Trp 
                405                 410                 415     


Phe Ser His His Leu Ser Asn Phe Gln Phe Arg Trp Ser Trp Glu Asp 
            420                 425                 430         


Trp Ser Asp Cys Leu Ser Gln Asp Pro Glu Ser Pro Lys Pro Lys Phe 
        435                 440                 445             


Val Arg Glu Val Leu Glu Lys Cys Met Arg Leu Ser Tyr His Gln Arg 
    450                 455                 460                 


Ile Leu Asp Ile Val Pro Pro Thr Phe Ser Ala Leu Cys Pro Ala Asn 
465                 470                 475                 480 


Pro Thr Cys Ile Tyr Lys Tyr Gly Asp Glu Ser Ser Asn Ser Leu Pro 
                485                 490                 495     


Gly His Ser Val Ala Leu Cys Leu Ala Val Ala Phe Lys Ser Lys Ala 
            500                 505                 510         


Thr Asn Asp Glu Ile Phe Ser Ile Leu Lys Asp Val Pro Asn Pro Asn 
        515                 520                 525             


Gln Asp Asp Asp Asp Asp Glu Gly Phe Ser Phe Asn Pro Leu Lys Ile 
    530                 535                 540                 


Glu Val Phe Val Gln Thr Leu Leu His Leu Ala Ala Lys Ser Phe Ser 
545                 550                 555                 560 


His Ser Phe Ser Ala Leu Ala Lys Phe His Glu Val Phe Lys Thr Leu 
                565                 570                 575     


Ala Glu Ser Asp Glu Gly Lys Leu His Val Leu Arg Val Met Phe Glu 
            580                 585                 590         


Val Trp Arg Asn His Pro Gln Met Ile Ala Val Leu Val Asp Lys Met 
        595                 600                 605             


Ile Arg Thr Gln Ile Val Asp Cys Ala Ala Val Ala Asn Trp Ile Phe 
    610                 615                 620                 


Ser Ser Glu Leu Ser Arg Asp Phe Thr Arg Leu Phe Val Trp Glu Ile 
625                 630                 635                 640 


Leu His Ser Thr Ile Arg Lys Met Asn Lys His Val Leu Lys Ile Gln 
                645                 650                 655     


Lys Glu Leu Glu Glu Ala Lys Glu Lys Leu Ala Arg Gln His Lys Arg 
            660                 665                 670         


Arg Ser Asp Asp Asp Asp Arg Ser Ser Asp Arg Lys Asp Gly Val Leu 
        675                 680                 685             


Glu Glu Gln Ile Glu Arg Leu Gln Glu Lys Val Glu Ser Ala Gln Ser 
    690                 695                 700                 


Glu Gln Lys Asn Leu Phe Leu Val Ile Phe Gln Arg Phe Ile Met Ile 
705                 710                 715                 720 


Leu Thr Glu His Leu Val Arg Cys Glu Thr Asp Gly Thr Ser Val Leu 
                725                 730                 735     


Thr Pro Trp Tyr Lys Asn Cys Ile Glu Arg Leu Gln Gln Ile Phe Leu 
            740                 745                 750         


Gln His His Gln Ile Ile Gln Gln Tyr Met Val Thr Leu Glu Asn Leu 
        755                 760                 765             


Leu Phe Thr Ala Glu Leu Asp Pro His Ile Leu Ala Val Phe Gln Gln 
    770                 775                 780                 


Phe Cys Ala Leu Gln Ala 
785                 790 


<210>  142
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Val Arg Phe Lys His Arg Tyr Leu Leu Cys Glu Leu Val Ser Asp 
1               5                   10                  15      


Asp Pro Arg Cys Arg Leu Ser Leu Asp Asp Arg Val Leu Ser Ser Leu 
            20                  25                  30          


Val Arg Asp Thr Ile Ala Arg Val His Gly Thr Phe Gly Ala Ala Ala 
        35                  40                  45              


Cys Ser Ile Gly Phe Ala Val Arg Tyr Leu Asn Ala Tyr Thr Gly Ile 
    50                  55                  60                  


Val Leu Leu Arg Cys Arg Lys Glu Phe Tyr Gln Leu Val Trp Ser Ala 
65                  70                  75                  80  


Leu Pro Phe Ile Thr Tyr Leu Glu Asn Lys Gly His Arg Tyr Pro Cys 
                85                  90                  95      


Phe Phe Asn Thr Leu His Val Gly Gly Thr Ile Arg Thr Cys Gln Lys 
            100                 105                 110         


Phe Leu Ile Gln Tyr Asn Arg Arg Gln Leu Leu Ile Leu Leu Gln Asn 
        115                 120                 125             


Cys Thr Asp Glu Gly Glu Arg Glu Ala Ile Gln Lys Ser Val Thr Arg 
    130                 135                 140                 


Ser Cys Leu Leu Glu Glu Glu Glu Glu Ser Gly Glu Glu Ala Ala Glu 
145                 150                 155                 160 


Ala Met Glu 
            


<210>  143
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ala Ala Val Lys Ala Ser Thr Ser Lys Ala Thr Arg Pro Trp Tyr 
1               5                   10                  15      


Ser His Pro Val Tyr Ala Arg Tyr Trp Gln His Tyr His Gln Ala Met 
            20                  25                  30          


Ala Trp Met Gln Ser His His Asn Ala Tyr Arg Lys Ala Val Glu Ser 
        35                  40                  45              


Cys Phe Asn Leu Pro Trp Tyr Leu Pro Ser Ala Leu Leu Pro Gln Ser 
    50                  55                  60                  


Ser Tyr Asp Asn Glu Ala Ala Tyr Pro Gln Ser Phe Tyr Asp His His 
65                  70                  75                  80  


Val Ala Trp Gln Asp Tyr Pro Cys Ser Ser Ser His Phe Arg Arg Ser 
                85                  90                  95      


Gly Gln His Pro Arg Tyr Ser Ser Arg Ile Gln Ala Ser Thr Lys Glu 
            100                 105                 110         


Asp Gln Ala Leu Ser Lys Glu Glu Glu Met Glu Thr Glu Ser Asp Ala 
        115                 120                 125             


Glu Val Glu Cys Asp Leu Ser Asn Met Glu Ile Thr Glu Glu Leu Arg 
    130                 135                 140                 


Gln Tyr Phe Ala Glu Thr Glu Arg His Arg Glu Glu Arg Arg Arg Gln 
145                 150                 155                 160 


Gln Gln Leu Asp Ala Glu Arg Leu Asp Ser Tyr Val Asn Ala Asp His 
                165                 170                 175     


Asp Leu Tyr Cys Asn Thr Arg Arg Ser Val Glu Ala Pro Thr Glu Arg 
            180                 185                 190         


Pro Gly Glu Arg Arg Gln Ala Glu Met Lys Arg Leu Tyr Gly Asp Ser 
        195                 200                 205             


Ala Ala Lys Ile Gln Ala Met Glu Ala Ala Val Gln Leu Ser Phe Asp 
    210                 215                 220                 


Lys His Cys Asp Arg Lys Gln Pro Lys Tyr Trp Pro Val Ile Pro Leu 
225                 230                 235                 240 


Lys Phe 
        


<210>  144
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ser Asn Ala Lys Glu Arg Lys His Ala Lys Lys Met Arg Asn Gln 
1               5                   10                  15      


Pro Thr Asn Val Thr Leu Ser Ser Gly Phe Val Ala Asp Arg Gly Val 
            20                  25                  30          


Lys His His Ser Gly Gly Glu Lys Pro Phe Gln Ala Gln Lys Gln Glu 
        35                  40                  45              


Pro His Pro Gly Thr Ser Arg Gln Arg Gln Thr Arg Val Asn Pro His 
    50                  55                  60                  


Ser Leu Pro Asp Pro Glu Val Asn Glu Gln Ser Ser Ser Lys Gly Met 
65                  70                  75                  80  


Phe Arg Lys Lys Gly Gly Trp Lys Ala Gly Pro Glu Gly Thr Ser Gln 
                85                  90                  95      


Glu Ile Pro Lys Tyr Ile Thr Ala Ser Thr Phe Ala Gln Ala Arg Ala 
            100                 105                 110         


Ala Glu Ile Ser Ala Met Leu Lys Ala Val Thr Gln Lys Ser Ser Asn 
        115                 120                 125             


Ser Leu Val Phe Gln Thr Leu Pro Arg His Met Arg Arg Arg Ala Met 
    130                 135                 140                 


Ser His Asn Val Lys Arg Leu Pro Arg Arg Leu Gln Glu Ile Ala Gln 
145                 150                 155                 160 


Lys Glu Ala Glu Lys Ala Val His Gln Lys Lys Glu His Ser Lys Asn 
                165                 170                 175     


Lys Cys His Lys Ala Arg Arg Cys His Met Asn Arg Thr Leu Glu Phe 
            180                 185                 190         


Asn Arg Arg Gln Lys Lys Asn Ile Trp Leu Glu Thr His Ile Trp His 
        195                 200                 205             


Ala Lys Arg Phe His Met Val Lys Lys Trp Gly Tyr Cys Leu Gly Glu 
    210                 215                 220                 


Arg Pro Thr Val Lys Ser His Arg Ala Cys Tyr Arg Ala Met Thr Asn 
225                 230                 235                 240 


Arg Cys Leu Leu Gln Asp Leu Ser Tyr Tyr Cys Cys Leu Glu Leu Lys 
                245                 250                 255     


Gly Lys Glu Glu Glu Ile Leu Lys Ala Leu Ser Gly Met Cys Asn Ile 
            260                 265                 270         


Asp Thr Gly Leu Thr Phe Ala Ala Val His Cys Leu Ser Gly Lys Arg 
        275                 280                 285             


Gln Gly Ser Leu Val Leu Tyr Arg Val Asn Lys Tyr Pro Arg Glu Met 
    290                 295                 300                 


Leu Gly Pro Val Thr Phe Ile Trp Lys Ser Gln Arg Thr Pro Gly Asp 
305                 310                 315                 320 


Pro Ser Glu Ser Arg Gln Leu Trp Ile Trp Leu His Pro Thr Leu Lys 
                325                 330                 335     


Gln Asp Ile Leu Glu Glu Ile Lys Ala Ala Cys Gln Cys Val Glu Pro 
            340                 345                 350         


Ile Lys Ser Ala Val Cys Ile Ala Asp Pro Leu Pro Thr Pro Ser Gln 
        355                 360                 365             


Glu Lys Ser Gln Thr Glu Leu Pro Asp Glu Lys Ile Gly Lys Lys Arg 
    370                 375                 380                 


Lys Arg Lys Asp Asp Gly Glu Asn Ala Lys Pro Ile Lys Lys Ile Ile 
385                 390                 395                 400 


Gly Asp Gly Thr Arg Asp Pro Cys Leu Pro Tyr Ser Trp Ile Ser Pro 
                405                 410                 415     


Thr Thr Gly Ile Ile Ile Ser Asp Leu Thr Met Glu Met Asn Arg Phe 
            420                 425                 430         


Arg Leu Ile Gly Pro Leu Ser His Ser Ile Leu Thr Glu Ala Ile Lys 
        435                 440                 445             


Ala Ala Ser Val His Thr Val Gly Glu Asp Thr Glu Glu Thr Pro His 
    450                 455                 460                 


Arg Trp Trp Ile Glu Thr Cys Lys Lys Pro Asp Ser Val Ser Leu His 
465                 470                 475                 480 


Cys Arg Gln Glu Ala Ile Phe Glu Leu Leu Gly Gly Ile Thr Ser Pro 
                485                 490                 495     


Ala Glu Ile Pro Ala Gly Thr Ile Leu Gly Leu Thr Val Gly Asp Pro 
            500                 505                 510         


Arg Ile Asn Leu Pro Gln Lys Lys Ser Lys Ala Leu Pro Asn Pro Glu 
        515                 520                 525             


Lys Cys Gln Asp Asn Glu Lys Val Arg Gln Leu Leu Leu Glu Gly Val 
    530                 535                 540                 


Pro Val Glu Cys Thr His Ser Phe Ile Trp Asn Gln Asp Ile Cys Lys 
545                 550                 555                 560 


Ser Val Thr Glu Asn Lys Ile Ser Asp Gln Asp Leu Asn Arg Met Arg 
                565                 570                 575     


Ser Glu Leu Leu Val Pro Gly Ser Gln Leu Ile Leu Gly Pro His Glu 
            580                 585                 590         


Ser Lys Ile Pro Ile Leu Leu Ile Gln Gln Pro Gly Lys Val Thr Gly 
        595                 600                 605             


Glu Asp Arg Leu Gly Trp Gly Ser Gly Trp Asp Val Leu Leu Pro Lys 
    610                 615                 620                 


Gly Trp Gly Met Ala Phe Trp Ile Pro Phe Ile Tyr Arg Gly Val Arg 
625                 630                 635                 640 


Val Gly Gly Leu Lys Glu Ser Ala Val His Ser Gln Tyr Lys Arg Ser 
                645                 650                 655     


Pro Asn Val Pro Gly Asp Phe Pro Asp Cys Pro Ala Gly Met Leu Phe 
            660                 665                 670         


Ala Glu Glu Gln Ala Lys Asn Leu Leu Glu Lys Tyr Lys Arg Arg Pro 
        675                 680                 685             


Pro Ala Lys Arg Pro Asn Tyr Val Lys Leu Gly Thr Leu Ala Pro Phe 
    690                 695                 700                 


Cys Cys Pro Trp Glu Gln Leu Thr Gln Asp Trp Glu Ser Arg Val Gln 
705                 710                 715                 720 


Ala Tyr Glu Glu Pro Ser Val Ala Ser Ser Pro Asn Gly Lys Glu Ser 
                725                 730                 735     


Asp Leu Arg Arg Ser Glu Val Pro Cys Ala Pro Met Pro Lys Lys Thr 
            740                 745                 750         


His Gln Pro Ser Asp Glu Val Gly Thr Ser Ile Glu His Pro Arg Glu 
        755                 760                 765             


Ala Glu Glu Val Met Asp Ala Gly Cys Gln Glu Ser Ala Gly Pro Glu 
    770                 775                 780                 


Arg Ile Thr Asp Gln Glu Ala Ser Glu Asn His Val Ala Ala Thr Gly 
785                 790                 795                 800 


Ser His Leu Cys Val Leu Arg Ser Arg Lys Leu Leu Lys Gln Leu Ser 
                805                 810                 815     


Ala Trp Cys Gly Pro Ser Ser Glu Asp Ser Arg Gly Gly Arg Arg Ala 
            820                 825                 830         


Pro Gly Arg Gly Gln Gln Gly Leu Thr Arg Glu Ala Cys Leu Ser Ile 
        835                 840                 845             


Leu Gly His Phe Pro Arg Ala Leu Val Trp Val Ser Leu Ser Leu Leu 
    850                 855                 860                 


Ser Lys Gly Ser Pro Glu Pro His Thr Met Ile Cys Val Pro Ala Lys 
865                 870                 875                 880 


Glu Asp Phe Leu Gln Leu His Glu Asp Trp His Tyr Cys Gly Pro Gln 
                885                 890                 895     


Glu Ser Lys His Ser Asp Pro Phe Arg Ser Lys Ile Leu Lys Gln Lys 
            900                 905                 910         


Glu Lys Lys Lys Arg Glu Lys Arg Gln Lys Pro Gly Arg Ala Ser Ser 
        915                 920                 925             


Asp Gly Pro Ala Gly Glu Glu Pro Val Ala Gly Gln Glu Ala Leu Thr 
    930                 935                 940                 


Leu Gly Leu Trp Ser Gly Pro Leu Pro Arg Val Thr Leu His Cys Ser 
945                 950                 955                 960 


Arg Thr Leu Leu Gly Phe Val Thr Gln Gly Asp Phe Ser Met Ala Val 
                965                 970                 975     


Gly Cys Gly Glu Ala Leu Gly Phe Val Ser Leu Thr Gly Leu Leu Asp 
            980                 985                 990         


Met Leu Ser Ser Gln Pro Ala Ala  Gln Arg Gly Leu Val  Leu Leu Arg 
        995                 1000                 1005             


Pro Pro  Ala Ser Leu Gln Tyr  Arg Phe Ala Arg Ile  Ala Ile Glu 
    1010                 1015                 1020             


Val 
    


<210>  145
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ala Asp Val Leu Asp Leu His Glu Ala Gly Gly Glu Asp Phe Ala 
1               5                   10                  15      


Met Asp Glu Asp Gly Asp Glu Ser Ile His Lys Leu Lys Glu Lys Ala 
            20                  25                  30          


Lys Lys Arg Lys Gly Arg Gly Phe Gly Ser Glu Glu Gly Ser Arg Ala 
        35                  40                  45              


Arg Met Arg Glu Asp Tyr Asp Ser Val Glu Gln Asp Gly Asp Glu Pro 
    50                  55                  60                  


Gly Pro Gln Arg Ser Val Glu Gly Trp Ile Leu Phe Val Thr Gly Val 
65                  70                  75                  80  


His Glu Glu Ala Thr Glu Glu Asp Ile His Asp Lys Phe Ala Glu Tyr 
                85                  90                  95      


Gly Glu Ile Lys Asn Ile His Leu Asn Leu Asp Arg Arg Thr Gly Tyr 
            100                 105                 110         


Leu Lys Gly Tyr Thr Leu Val Glu Tyr Glu Thr Tyr Lys Glu Ala Gln 
        115                 120                 125             


Ala Ala Met Glu Gly Leu Asn Gly Gln Asp Leu Met Gly Gln Pro Ile 
    130                 135                 140                 


Ser Val Asp Trp Cys Phe Val Arg Gly Pro Pro Lys Gly Lys Arg Arg 
145                 150                 155                 160 


Gly Gly Arg Arg Arg Ser Arg Ser Pro Asp Arg Arg Arg Arg 
                165                 170                 


<210>  146
<211>  1436
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Leu His Leu Ser Ala Ala Pro Pro Ala Pro Pro Pro Glu Val Thr 
1               5                   10                  15      


Ala Thr Ala Arg Pro Cys Leu Cys Ser Val Gly Arg Arg Gly Asp Gly 
            20                  25                  30          


Gly Lys Met Ala Ala Ala Gly Ala Leu Glu Arg Ser Phe Val Glu Leu 
        35                  40                  45              


Ser Gly Ala Glu Arg Glu Arg Pro Arg His Phe Arg Glu Phe Thr Val 
    50                  55                  60                  


Cys Ser Ile Gly Thr Ala Asn Ala Val Ala Gly Ala Val Lys Tyr Ser 
65                  70                  75                  80  


Glu Ser Ala Gly Gly Phe Tyr Tyr Val Glu Ser Gly Lys Leu Phe Ser 
                85                  90                  95      


Val Thr Arg Asn Arg Phe Ile His Trp Lys Thr Ser Gly Asp Thr Leu 
            100                 105                 110         


Glu Leu Met Glu Glu Ser Leu Asp Ile Asn Leu Leu Asn Asn Ala Ile 
        115                 120                 125             


Arg Leu Lys Phe Gln Asn Cys Ser Val Leu Pro Gly Gly Val Tyr Val 
    130                 135                 140                 


Ser Glu Thr Gln Asn Arg Val Ile Ile Leu Met Leu Thr Asn Gln Thr 
145                 150                 155                 160 


Val His Arg Leu Leu Leu Pro His Pro Ser Arg Met Tyr Arg Ser Glu 
                165                 170                 175     


Leu Val Val Asp Ser Gln Met Gln Ser Ile Phe Thr Asp Ile Gly Lys 
            180                 185                 190         


Val Asp Phe Thr Asp Pro Cys Asn Tyr Gln Leu Ile Pro Ala Val Pro 
        195                 200                 205             


Gly Ile Ser Pro Asn Ser Thr Ala Ser Thr Ala Trp Leu Ser Ser Asp 
    210                 215                 220                 


Gly Glu Ala Leu Phe Ala Leu Pro Cys Ala Ser Gly Gly Ile Phe Val 
225                 230                 235                 240 


Leu Lys Leu Pro Pro Tyr Asp Ile Pro Gly Met Val Ser Val Val Glu 
                245                 250                 255     


Leu Lys Gln Ser Ser Val Met Gln Arg Leu Leu Thr Gly Trp Met Pro 
            260                 265                 270         


Thr Ala Ile Arg Gly Asp Gln Ser Pro Ser Asp Arg Pro Leu Ser Leu 
        275                 280                 285             


Ala Val His Cys Val Glu His Asp Ala Phe Ile Phe Ala Leu Cys Gln 
    290                 295                 300                 


Asp His Lys Leu Arg Met Trp Ser Tyr Lys Glu Gln Met Cys Leu Met 
305                 310                 315                 320 


Val Ala Asp Met Leu Glu Tyr Val Pro Val Lys Lys Asp Leu Arg Leu 
                325                 330                 335     


Thr Ala Gly Thr Gly His Lys Leu Arg Leu Ala Tyr Ser Pro Thr Met 
            340                 345                 350         


Gly Leu Tyr Leu Gly Ile Tyr Met His Ala Pro Lys Arg Gly Gln Phe 
        355                 360                 365             


Cys Ile Phe Gln Leu Val Ser Thr Glu Ser Asn Arg Tyr Ser Leu Asp 
    370                 375                 380                 


His Ile Ser Ser Leu Phe Thr Ser Gln Glu Thr Leu Ile Asp Phe Ala 
385                 390                 395                 400 


Leu Thr Ser Thr Asp Ile Trp Ala Leu Trp His Asp Ala Glu Asn Gln 
                405                 410                 415     


Thr Val Val Lys Tyr Ile Asn Phe Glu His Asn Val Ala Gly Gln Trp 
            420                 425                 430         


Asn Pro Val Phe Met Gln Pro Leu Pro Glu Glu Glu Ile Val Ile Arg 
        435                 440                 445             


Asp Asp Gln Asp Pro Arg Glu Met Tyr Leu Gln Ser Leu Phe Thr Pro 
    450                 455                 460                 


Gly Gln Phe Thr Asn Glu Ala Leu Cys Lys Ala Leu Gln Ile Phe Cys 
465                 470                 475                 480 


Arg Gly Thr Glu Arg Asn Leu Asp Leu Ser Trp Ser Glu Leu Lys Lys 
                485                 490                 495     


Glu Val Thr Leu Ala Val Glu Asn Glu Leu Gln Gly Ser Val Thr Glu 
            500                 505                 510         


Tyr Glu Phe Ser Gln Glu Glu Phe Arg Asn Leu Gln Gln Glu Phe Trp 
        515                 520                 525             


Cys Lys Phe Tyr Ala Cys Cys Leu Gln Tyr Gln Glu Ala Leu Ser His 
    530                 535                 540                 


Pro Leu Ala Leu His Leu Asn Pro His Thr Asn Met Val Cys Leu Leu 
545                 550                 555                 560 


Lys Lys Gly Tyr Leu Ser Phe Leu Ile Pro Ser Ser Leu Val Asp His 
                565                 570                 575     


Leu Tyr Leu Leu Pro Tyr Glu Asn Leu Leu Thr Glu Asp Glu Thr Thr 
            580                 585                 590         


Ile Ser Asp Asp Val Asp Ile Ala Arg Asp Val Ile Cys Leu Ile Lys 
        595                 600                 605             


Cys Leu Arg Leu Ile Glu Glu Ser Val Thr Val Asp Met Ser Val Ile 
    610                 615                 620                 


Met Glu Met Ser Cys Tyr Asn Leu Gln Ser Pro Glu Lys Ala Ala Glu 
625                 630                 635                 640 


Gln Ile Leu Glu Asp Met Ile Thr Ile Asp Val Glu Asn Val Met Glu 
                645                 650                 655     


Asp Ile Cys Ser Lys Leu Gln Glu Ile Arg Asn Pro Ile His Ala Ile 
            660                 665                 670         


Gly Leu Leu Ile Arg Glu Met Asp Tyr Glu Thr Glu Val Glu Met Glu 
        675                 680                 685             


Lys Gly Phe Asn Pro Ala Gln Pro Leu Asn Ile Arg Met Asn Leu Thr 
    690                 695                 700                 


Gln Leu Tyr Gly Ser Asn Thr Ala Gly Tyr Ile Val Cys Arg Gly Val 
705                 710                 715                 720 


His Lys Ile Ala Ser Thr Arg Phe Leu Ile Cys Arg Asp Leu Leu Ile 
                725                 730                 735     


Leu Gln Gln Leu Leu Met Arg Leu Gly Asp Ala Val Ile Trp Gly Thr 
            740                 745                 750         


Gly Gln Leu Phe Gln Ala Gln Gln Asp Leu Leu His Arg Thr Ala Pro 
        755                 760                 765             


Leu Leu Leu Ser Tyr Tyr Leu Ile Lys Trp Gly Ser Glu Cys Leu Ala 
    770                 775                 780                 


Thr Asp Val Pro Leu Asp Thr Leu Glu Ser Asn Leu Gln His Leu Ser 
785                 790                 795                 800 


Val Leu Glu Leu Thr Asp Ser Gly Ala Leu Met Ala Asn Arg Phe Val 
                805                 810                 815     


Ser Ser Pro Gln Thr Ile Val Glu Leu Phe Phe Gln Glu Val Ala Arg 
            820                 825                 830         


Lys His Ile Ile Ser His Leu Phe Ser Gln Pro Lys Ala Pro Leu Ser 
        835                 840                 845             


Gln Thr Gly Leu Asn Trp Pro Glu Met Ile Thr Ala Ile Thr Ser Tyr 
    850                 855                 860                 


Leu Leu Gln Leu Leu Trp Pro Ser Asn Pro Gly Cys Leu Phe Leu Glu 
865                 870                 875                 880 


Cys Leu Met Gly Asn Cys Gln Tyr Val Gln Leu Gln Asp Tyr Ile Gln 
                885                 890                 895     


Leu Leu His Pro Trp Cys Gln Val Asn Val Gly Ser Cys Arg Phe Met 
            900                 905                 910         


Leu Gly Arg Cys Tyr Leu Val Thr Gly Glu Gly Gln Lys Ala Leu Glu 
        915                 920                 925             


Cys Phe Cys Gln Ala Ala Ser Glu Val Gly Lys Glu Glu Phe Leu Asp 
    930                 935                 940                 


Arg Leu Ile Arg Ser Glu Asp Gly Glu Ile Val Ser Thr Pro Arg Leu 
945                 950                 955                 960 


Gln Tyr Tyr Asp Lys Val Leu Arg Leu Leu Asp Val Ile Gly Leu Pro 
                965                 970                 975     


Glu Leu Val Ile Gln Leu Ala Thr Ser Ala Ile Thr Glu Ala Gly Asp 
            980                 985                 990         


Asp Trp Lys Ser Gln Ala Thr Leu  Arg Thr Cys Ile Phe  Lys His His 
        995                 1000                 1005             


Leu Asp  Leu Gly His Asn Ser  Gln Ala Tyr Glu Ala  Leu Thr Gln 
    1010                 1015                 1020             


Ile Pro  Asp Ser Ser Arg Gln  Leu Asp Cys Leu Arg  Gln Leu Val 
    1025                 1030                 1035             


Val Val  Leu Cys Glu Arg Ser  Gln Leu Gln Asp Leu  Val Glu Phe 
    1040                 1045                 1050             


Pro Tyr  Val Asn Leu His Asn  Glu Val Val Gly Ile  Ile Glu Ser 
    1055                 1060                 1065             


Arg Ala  Arg Ala Val Asp Leu  Met Thr His Asn Tyr  Tyr Glu Leu 
    1070                 1075                 1080             


Leu Tyr  Ala Phe His Ile Tyr  Arg His Asn Tyr Arg  Lys Ala Gly 
    1085                 1090                 1095             


Thr Val  Met Phe Glu Tyr Gly  Met Arg Leu Gly Arg  Glu Val Arg 
    1100                 1105                 1110             


Thr Leu  Arg Gly Leu Glu Lys  Gln Gly Asn Cys Tyr  Leu Ala Ala 
    1115                 1120                 1125             


Leu Asn  Cys Leu Arg Leu Ile  Arg Pro Glu Tyr Ala  Trp Ile Val 
    1130                 1135                 1140             


Gln Pro  Val Ser Gly Ala Val  Tyr Asp Arg Pro Gly  Ala Ser Pro 
    1145                 1150                 1155             


Lys Arg  Asn His Asp Gly Glu  Cys Thr Ala Ala Pro  Thr Asn Arg 
    1160                 1165                 1170             


Gln Ile  Glu Ile Leu Glu Leu  Glu Asp Leu Glu Lys  Glu Cys Ser 
    1175                 1180                 1185             


Leu Ala  Arg Ile Arg Leu Thr  Leu Ala Gln His Asp  Pro Ser Ala 
    1190                 1195                 1200             


Val Ala  Val Ala Gly Ser Ser  Ser Ala Glu Glu Met  Val Thr Leu 
    1205                 1210                 1215             


Leu Val  Gln Ala Gly Leu Phe  Asp Thr Ala Ile Ser  Leu Cys Gln 
    1220                 1225                 1230             


Thr Phe  Lys Leu Pro Leu Thr  Pro Val Phe Glu Gly  Leu Ala Phe 
    1235                 1240                 1245             


Lys Cys  Ile Lys Leu Gln Phe  Gly Gly Glu Ala Ala  Gln Ala Glu 
    1250                 1255                 1260             


Ala Trp  Ala Trp Leu Ala Ala  Asn Gln Leu Ser Ser  Val Ile Thr 
    1265                 1270                 1275             


Thr Lys  Glu Ser Ser Ala Thr  Asp Glu Ala Trp Arg  Leu Leu Ser 
    1280                 1285                 1290             


Thr Tyr  Leu Glu Arg Tyr Lys  Val Gln Asn Asn Leu  Tyr His His 
    1295                 1300                 1305             


Cys Val  Ile Asn Lys Leu Leu  Ser His Gly Val Pro  Leu Pro Asn 
    1310                 1315                 1320             


Trp Leu  Ile Asn Ser Tyr Lys  Lys Val Asp Ala Ala  Glu Leu Leu 
    1325                 1330                 1335             


Arg Leu  Tyr Leu Asn Tyr Asp  Leu Leu Glu Glu Ala  Val Asp Leu 
    1340                 1345                 1350             


Val Ser  Glu Tyr Val Asp Ala  Val Leu Gly Lys Gly  His Gln Tyr 
    1355                 1360                 1365             


Phe Gly  Ile Glu Phe Pro Leu  Ser Ala Thr Ala Pro  Met Val Trp 
    1370                 1375                 1380             


Leu Pro  Tyr Ser Ser Ile Asp  Gln Leu Leu Gln Ala  Leu Gly Glu 
    1385                 1390                 1395             


Asn Ser  Ala Asn Ser His Asn  Ile Ala Leu Ser Gln  Lys Ile Leu 
    1400                 1405                 1410             


Asp Lys  Leu Glu Asp Tyr Gln  Gln Lys Val Asp Lys  Ala Thr Arg 
    1415                 1420                 1425             


Asp Leu  Leu Tyr Arg Arg Thr  Leu 
    1430                 1435     


<210>  147
<211>  1475
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ala Ser Gly Ala Gly Gly Val Gly Gly Gly Gly Gly Gly Lys Ile 
1               5                   10                  15      


Arg Thr Arg Arg Cys His Gln Gly Pro Ile Lys Pro Tyr Gln Gln Gly 
            20                  25                  30          


Arg Gln Gln His Gln Gly Ile Leu Ser Arg Val Thr Glu Ser Val Lys 
        35                  40                  45              


Asn Ile Val Pro Gly Trp Leu Gln Arg Tyr Phe Asn Lys Asn Glu Asp 
    50                  55                  60                  


Val Cys Ser Cys Ser Thr Asp Thr Ser Glu Val Pro Arg Trp Pro Glu 
65                  70                  75                  80  


Asn Lys Glu Asp His Leu Val Tyr Ala Asp Glu Glu Ser Ser Asn Ile 
                85                  90                  95      


Thr Asp Gly Arg Ile Thr Pro Glu Pro Ala Val Ser Asn Thr Glu Glu 
            100                 105                 110         


Pro Ser Thr Thr Ser Thr Ala Ser Asn Tyr Pro Asp Val Leu Thr Arg 
        115                 120                 125             


Pro Ser Leu His Arg Ser His Leu Asn Phe Ser Met Leu Glu Ser Pro 
    130                 135                 140                 


Ala Leu His Cys Gln Pro Ser Thr Ser Ser Ala Phe Pro Ile Gly Ser 
145                 150                 155                 160 


Ser Gly Phe Ser Leu Val Lys Glu Ile Lys Asp Ser Thr Ser Gln His 
                165                 170                 175     


Asp Asp Asp Asn Ile Ser Thr Thr Ser Gly Phe Ser Ser Arg Ala Ser 
            180                 185                 190         


Asp Lys Asp Ile Thr Val Ser Lys Asn Thr Ser Leu Pro Pro Leu Trp 
        195                 200                 205             


Ser Pro Glu Ala Glu Arg Ser His Ser Leu Ser Gln His Thr Ala Thr 
    210                 215                 220                 


Ser Ser Lys Lys Pro Ala Phe Asn Leu Ser Ala Phe Gly Thr Leu Ser 
225                 230                 235                 240 


Pro Ser Leu Gly Asn Ser Ser Ile Leu Lys Thr Ser Gln Leu Gly Asp 
                245                 250                 255     


Ser Pro Phe Tyr Pro Gly Lys Thr Thr Tyr Gly Gly Ala Ala Ala Ala 
            260                 265                 270         


Val Arg Gln Ser Lys Leu Arg Asn Thr Pro Tyr Gln Ala Pro Val Arg 
        275                 280                 285             


Arg Gln Met Lys Ala Lys Gln Leu Ser Ala Gln Ser Tyr Gly Val Thr 
    290                 295                 300                 


Ser Ser Thr Ala Arg Arg Ile Leu Gln Ser Leu Glu Lys Met Ser Ser 
305                 310                 315                 320 


Pro Leu Ala Asp Ala Lys Arg Ile Pro Ser Ile Val Ser Ser Pro Leu 
                325                 330                 335     


Asn Ser Pro Leu Asp Arg Ser Gly Ile Asp Ile Thr Asp Phe Gln Ala 
            340                 345                 350         


Lys Arg Glu Lys Val Asp Ser Gln Tyr Pro Pro Val Gln Arg Leu Met 
        355                 360                 365             


Thr Pro Lys Pro Val Ser Ile Ala Thr Asn Arg Ser Val Tyr Phe Lys 
    370                 375                 380                 


Pro Ser Leu Thr Pro Ser Gly Glu Phe Arg Lys Thr Asn Gln Arg Ile 
385                 390                 395                 400 


Asp Asn Lys Cys Ser Thr Gly Tyr Glu Lys Asn Met Thr Pro Gly Gln 
                405                 410                 415     


Asn Arg Glu Gln Arg Glu Ser Gly Phe Ser Tyr Pro Asn Phe Ser Leu 
            420                 425                 430         


Pro Ala Ala Asn Gly Leu Ser Ser Gly Val Gly Gly Gly Gly Gly Lys 
        435                 440                 445             


Met Arg Arg Glu Arg Thr Arg Phe Val Ala Ser Lys Pro Leu Glu Glu 
    450                 455                 460                 


Glu Glu Met Glu Val Pro Val Leu Pro Lys Ile Ser Leu Pro Ile Thr 
465                 470                 475                 480 


Ser Ser Ser Leu Pro Thr Phe Asn Phe Ser Ser Pro Glu Ile Thr Thr 
                485                 490                 495     


Ser Ser Pro Ser Pro Ile Asn Ser Ser Gln Ala Leu Thr Asn Lys Val 
            500                 505                 510         


Gln Met Thr Ser Pro Ser Ser Thr Gly Ser Pro Met Phe Lys Phe Ser 
        515                 520                 525             


Ser Pro Ile Val Lys Ser Thr Glu Ala Asn Val Leu Pro Pro Ser Ser 
    530                 535                 540                 


Ile Gly Phe Thr Phe Ser Val Pro Val Ala Lys Thr Ala Glu Leu Ser 
545                 550                 555                 560 


Gly Ser Ser Ser Thr Leu Glu Pro Ile Ile Ser Ser Ser Ala His His 
                565                 570                 575     


Val Thr Thr Val Asn Ser Thr Asn Cys Lys Lys Thr Pro Pro Glu Asp 
            580                 585                 590         


Cys Glu Gly Pro Phe Arg Pro Ala Glu Ile Leu Lys Glu Gly Ser Val 
        595                 600                 605             


Leu Asp Ile Leu Lys Ser Pro Gly Phe Ala Ser Pro Lys Ile Asp Ser 
    610                 615                 620                 


Val Ala Ala Gln Pro Thr Ala Thr Ser Pro Val Val Tyr Thr Arg Pro 
625                 630                 635                 640 


Ala Ile Ser Ser Phe Ser Ser Ser Gly Ile Gly Phe Gly Glu Ser Leu 
                645                 650                 655     


Lys Ala Gly Ser Ser Trp Gln Cys Asp Thr Cys Leu Leu Gln Asn Lys 
            660                 665                 670         


Val Thr Asp Asn Lys Cys Ile Ala Cys Gln Ala Ala Lys Leu Ser Pro 
        675                 680                 685             


Arg Asp Thr Ala Lys Gln Thr Gly Ile Glu Thr Pro Asn Lys Ser Gly 
    690                 695                 700                 


Lys Thr Thr Leu Ser Ala Ser Gly Thr Gly Phe Gly Asp Lys Phe Lys 
705                 710                 715                 720 


Pro Val Ile Gly Thr Trp Asp Cys Asp Thr Cys Leu Val Gln Asn Lys 
                725                 730                 735     


Pro Glu Ala Ile Lys Cys Val Ala Cys Glu Thr Pro Lys Pro Gly Thr 
            740                 745                 750         


Cys Val Lys Arg Ala Leu Thr Leu Thr Val Val Ser Glu Ser Ala Glu 
        755                 760                 765             


Thr Met Thr Ala Ser Ser Ser Ser Cys Thr Val Thr Thr Gly Thr Leu 
    770                 775                 780                 


Gly Phe Gly Asp Lys Phe Lys Arg Pro Ile Gly Ser Trp Glu Cys Ser 
785                 790                 795                 800 


Val Cys Cys Val Ser Asn Asn Ala Glu Asp Asn Lys Cys Val Ser Cys 
                805                 810                 815     


Met Ser Glu Lys Pro Gly Ser Ser Val Pro Ala Ser Ser Ser Ser Thr 
            820                 825                 830         


Val Pro Val Ser Leu Pro Ser Gly Gly Ser Leu Gly Leu Glu Lys Phe 
        835                 840                 845             


Lys Lys Pro Glu Gly Ser Trp Asp Cys Glu Leu Cys Leu Val Gln Asn 
    850                 855                 860                 


Lys Ala Asp Ser Thr Lys Cys Leu Ala Cys Glu Ser Ala Lys Pro Gly 
865                 870                 875                 880 


Thr Lys Ser Gly Phe Lys Gly Phe Asp Thr Ser Ser Ser Ser Ser Asn 
                885                 890                 895     


Ser Ala Ala Ser Ser Ser Phe Lys Phe Gly Val Ser Ser Ser Ser Ser 
            900                 905                 910         


Gly Pro Ser Gln Thr Leu Thr Ser Thr Gly Asn Phe Lys Phe Gly Asp 
        915                 920                 925             


Gln Gly Gly Phe Lys Ile Gly Val Ser Ser Asp Ser Gly Ser Ile Asn 
    930                 935                 940                 


Pro Met Ser Glu Gly Phe Lys Phe Ser Lys Pro Ile Gly Asp Phe Lys 
945                 950                 955                 960 


Phe Gly Val Ser Ser Glu Ser Lys Pro Glu Glu Val Lys Lys Asp Ser 
                965                 970                 975     


Lys Asn Asp Asn Phe Lys Phe Gly Leu Ser Ser Gly Leu Ser Asn Pro 
            980                 985                 990         


Val Ser Leu Thr Pro Phe Gln Phe  Gly Val Ser Asn Leu  Gly Gln Glu 
        995                 1000                 1005             


Glu Lys  Lys Glu Glu Leu Pro  Lys Ser Ser Ser Ala  Gly Phe Ser 
    1010                 1015                 1020             


Phe Gly  Thr Gly Val Ile Asn  Ser Thr Pro Ala Pro  Ala Asn Thr 
    1025                 1030                 1035             


Ile Val  Thr Ser Glu Asn Lys  Ser Ser Phe Asn Leu  Gly Thr Ile 
    1040                 1045                 1050             


Glu Thr  Lys Ser Ala Ser Val  Ala Pro Phe Thr Cys  Lys Thr Ser 
    1055                 1060                 1065             


Glu Ala  Lys Lys Glu Glu Met  Pro Ala Thr Lys Gly  Gly Phe Ser 
    1070                 1075                 1080             


Phe Gly  Asn Val Glu Pro Ala  Ser Leu Pro Ser Ala  Ser Val Phe 
    1085                 1090                 1095             


Val Leu  Gly Arg Thr Glu Glu  Lys Gln Gln Glu Pro  Val Thr Ser 
    1100                 1105                 1110             


Thr Ser  Leu Val Phe Gly Lys  Lys Ala Asp Asn Glu  Glu Pro Lys 
    1115                 1120                 1125             


Cys Gln  Pro Val Phe Ser Phe  Gly Asn Ser Glu Gln  Thr Lys Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ser Lys Ser Thr  Phe Ser Phe Ser Met  Thr Lys Pro 
    1145                 1150                 1155             


Ser Glu  Lys Glu Ser Glu Gln  Pro Ala Lys Ala Thr  Phe Ala Phe 
    1160                 1165                 1170             


Gly Ala  Gln Thr Ser Thr Thr  Ala Asp Gln Gly Ala  Ala Lys Pro 
    1175                 1180                 1185             


Val Phe  Ser Phe Leu Asn Asn  Ser Ser Ser Ser Ser  Ser Thr Pro 
    1190                 1195                 1200             


Ala Thr  Ser Ala Gly Gly Gly  Ile Phe Gly Ser Ser  Thr Ser Ser 
    1205                 1210                 1215             


Ser Asn  Pro Pro Val Ala Thr  Phe Val Phe Gly Gln  Ser Ser Asn 
    1220                 1225                 1230             


Pro Val  Ser Ser Ser Ala Phe  Gly Asn Thr Ala Glu  Ser Ser Thr 
    1235                 1240                 1245             


Ser Gln  Ser Leu Leu Phe Ser  Gln Asp Ser Lys Leu  Ala Thr Thr 
    1250                 1255                 1260             


Ser Ser  Thr Gly Thr Ala Val  Thr Pro Phe Val Phe  Gly Pro Gly 
    1265                 1270                 1275             


Ala Ser  Ser Asn Asn Thr Thr  Thr Ser Gly Phe Gly  Phe Gly Ala 
    1280                 1285                 1290             


Thr Thr  Thr Ser Ser Ser Ala  Gly Ser Ser Phe Val  Phe Gly Thr 
    1295                 1300                 1305             


Gly Pro  Ser Ala Pro Ser Ala  Ser Pro Ala Phe Gly  Ala Asn Gln 
    1310                 1315                 1320             


Thr Pro  Thr Phe Gly Gln Ser  Gln Gly Ala Ser Gln  Pro Asn Pro 
    1325                 1330                 1335             


Pro Gly  Phe Gly Ser Ile Ser  Ser Ser Thr Ala Leu  Phe Pro Thr 
    1340                 1345                 1350             


Gly Ser  Gln Pro Ala Pro Pro  Thr Phe Gly Thr Val  Ser Ser Ser 
    1355                 1360                 1365             


Ser Gln  Pro Pro Val Phe Gly  Gln Gln Pro Ser Gln  Ser Ala Phe 
    1370                 1375                 1380             


Gly Ser  Gly Thr Thr Pro Asn  Ser Ser Ser Ala Phe  Gln Phe Gly 
    1385                 1390                 1395             


Ser Ser  Thr Thr Asn Phe Asn  Phe Thr Asn Asn Ser  Pro Ser Gly 
    1400                 1405                 1410             


Val Phe  Thr Phe Gly Ala Asn  Ser Ser Thr Pro Ala  Ala Ser Ala 
    1415                 1420                 1425             


Gln Pro  Ser Gly Ser Gly Gly  Phe Pro Phe Asn Gln  Ser Pro Ala 
    1430                 1435                 1440             


Ala Phe  Thr Val Gly Ser Asn  Gly Lys Asn Val Phe  Ser Ser Ser 
    1445                 1450                 1455             


Gly Thr  Ser Phe Ser Gly Arg  Lys Ile Lys Thr Ala  Val Arg Arg 
    1460                 1465                 1470             


Arg Lys  
    1475 


<210>  148
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Pro Ala Tyr Phe Gln Arg Pro Glu Asn Ala Leu Lys Arg Ala Asn 
1               5                   10                  15      


Glu Phe Leu Glu Val Gly Lys Lys Gln Pro Ala Leu Asp Val Leu Tyr 
            20                  25                  30          


Asp Val Met Lys Ser Lys Lys His Arg Thr Trp Gln Lys Ile His Glu 
        35                  40                  45              


Pro Ile Met Leu Lys Tyr Leu Glu Leu Cys Val Asp Leu Arg Lys Ser 
    50                  55                  60                  


His Leu Ala Lys Glu Gly Leu Tyr Gln Tyr Lys Asn Ile Cys Gln Gln 
65                  70                  75                  80  


Val Asn Ile Lys Ser Leu Glu Asp Val Val Arg Ala Tyr Leu Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Thr Glu Ala Ala Lys Glu Glu Ser Gln Gln Met Val 
            100                 105                 110         


Leu Asp Ile Glu Asp Leu Asp Asn Ile Gln Thr Pro Glu Ser Val Leu 
        115                 120                 125             


Leu Ser Ala Val Ser Gly Glu Asp Thr Gln Asp Arg Thr Asp Arg Leu 
    130                 135                 140                 


Leu Leu Thr Pro Trp Val Lys Phe Leu Trp Glu Ser Tyr Arg Gln Cys 
145                 150                 155                 160 


Leu Asp Leu Leu Arg Asn Asn Ser Arg Val Glu Arg Leu Tyr His Asp 
                165                 170                 175     


Ile Ala Gln Gln Ala Phe Lys Phe Cys Leu Gln Tyr Thr Arg Lys Ala 
            180                 185                 190         


Glu Phe Arg Lys Leu Cys Asp Asn Leu Arg Met His Leu Ser Gln Ile 
        195                 200                 205             


Gln Arg His His Asn Gln Ser Thr Ala Ile Asn Leu Asn Asn Pro Glu 
    210                 215                 220                 


Ser Gln Ser Met His Leu Glu Thr Arg Leu Val Gln Leu Asp Ser Ala 
225                 230                 235                 240 


Ile Ser Met Glu Leu Trp Gln Glu Ala Phe Lys Ala Val Glu Asp Ile 
                245                 250                 255     


His Gly Leu Phe Ser Leu Ser Lys Lys Pro Pro Lys Pro Gln Leu Met 
            260                 265                 270         


Ala Asn Tyr Tyr Asn Lys Val Ser Thr Val Phe Trp Lys Ser Gly Asn 
        275                 280                 285             


Ala Leu Phe His Ala Ser Thr Leu His Arg Leu Tyr His Leu Ser Arg 
    290                 295                 300                 


Glu Met Arg Lys Asn Leu Thr Gln Asp Glu Met Gln Arg Met Ser Thr 
305                 310                 315                 320 


Arg Val Leu Leu Ala Thr Leu Ser Ile Pro Ile Thr Pro Glu Arg Thr 
                325                 330                 335     


Asp Ile Ala Arg Leu Leu Asp Met Asp Gly Ile Ile Val Glu Lys Gln 
            340                 345                 350         


Arg Arg Leu Ala Thr Leu Leu Gly Leu Gln Ala Pro Pro Thr Arg Ile 
        355                 360                 365             


Gly Leu Ile Asn Asp Met Val Arg Phe Asn Val Leu Gln Tyr Val Val 
    370                 375                 380                 


Pro Glu Val Lys Asp Leu Tyr Asn Trp Leu Glu Val Glu Phe Asn Pro 
385                 390                 395                 400 


Leu Lys Leu Cys Glu Arg Val Thr Lys Val Leu Asn Trp Val Arg Glu 
                405                 410                 415     


Gln Pro Glu Lys Glu Pro Glu Leu Gln Gln Tyr Val Pro Gln Leu Gln 
            420                 425                 430         


Asn Asn Thr Ile Leu Arg Leu Leu Gln Gln Val Ser Gln Ile Tyr Gln 
        435                 440                 445             


Ser Ile Glu Phe Ser Arg Leu Thr Ser Leu Val Pro Phe Val Asp Ala 
    450                 455                 460                 


Phe Gln Leu Glu Arg Ala Ile Val Asp Ala Ala Arg His Cys Asp Leu 
465                 470                 475                 480 


Gln Val Arg Ile Asp His Thr Ser Arg Thr Leu Ser Phe Gly Ser Asp 
                485                 490                 495     


Leu Asn Tyr Ala Thr Arg Glu Asp Ala Pro Ile Gly Pro His Leu Gln 
            500                 505                 510         


Ser Met Pro Ser Glu Gln Ile Arg Asn Gln Leu Thr Ala Met Ser Ser 
        515                 520                 525             


Val Leu Ala Lys Ala Leu Glu Val Ile Lys Pro Ala His Ile Leu Gln 
    530                 535                 540                 


Glu Lys Glu Glu Gln His Gln Leu Ala Val Thr Ala Tyr Leu Lys Asn 
545                 550                 555                 560 


Ser Arg Lys Glu His Gln Arg Ile Leu Ala Arg Arg Gln Thr Ile Glu 
                565                 570                 575     


Glu Arg Lys Glu Arg Leu Glu Ser Leu Asn Ile Gln Arg Glu Lys Glu 
            580                 585                 590         


Glu Leu Glu Gln Arg Glu Ala Glu Leu Gln Lys Val Arg Lys Ala Glu 
        595                 600                 605             


Glu Glu Arg Leu Arg Gln Glu Ala Lys Glu Arg Glu Lys Glu Arg Ile 
    610                 615                 620                 


Leu Gln Glu His Glu Gln Ile Lys Lys Lys Thr Val Arg Glu Arg Leu 
625                 630                 635                 640 


Glu Gln Ile Lys Lys Thr Glu Leu Gly Ala Lys Ala Phe Lys Asp Ile 
                645                 650                 655     


Asp Ile Glu Asp Leu Glu Glu Leu Asp Pro Asp Phe Ile Met Ala Lys 
            660                 665                 670         


Gln Val Glu Gln Leu Glu Lys Glu Lys Lys Glu Leu Gln Glu Arg Leu 
        675                 680                 685             


Lys Asn Gln Glu Lys Lys Ile Asp Tyr Phe Glu Arg Ala Lys Arg Leu 
    690                 695                 700                 


Glu Glu Ile Pro Leu Ile Lys Ser Ala Tyr Glu Glu Gln Arg Ile Lys 
705                 710                 715                 720 


Asp Met Asp Leu Trp Glu Gln Gln Glu Glu Glu Arg Ile Thr Thr Met 
                725                 730                 735     


Gln Leu Glu Arg Glu Lys Ala Leu Glu His Lys Asn Arg Met Ser Arg 
            740                 745                 750         


Met Leu Glu Asp Arg Asp Leu Phe Val Met Arg Leu Lys Ala Ala Arg 
        755                 760                 765             


Gln Ser Val Tyr Glu Glu Lys Leu Lys Gln Phe Glu Glu Arg Leu Ala 
    770                 775                 780                 


Glu Glu Arg His Asn Arg Leu Glu Glu Arg Lys Arg Gln Arg Lys Glu 
785                 790                 795                 800 


Glu Arg Arg Ile Thr Tyr Tyr Arg Glu Lys Glu Glu Glu Glu Gln Arg 
                805                 810                 815     


Arg Ala Glu Glu Gln Met Leu Lys Glu Arg Glu Glu Arg Glu Arg Ala 
            820                 825                 830         


Glu Arg Ala Lys Arg Glu Glu Glu Leu Arg Glu Tyr Gln Glu Arg Val 
        835                 840                 845             


Lys Lys Leu Glu Glu Val Glu Arg Lys Lys Arg Gln Arg Glu Leu Glu 
    850                 855                 860                 


Ile Glu Glu Arg Glu Arg Arg Arg Glu Glu Glu Arg Arg Leu Gly Asp 
865                 870                 875                 880 


Ser Ser Leu Ser Arg Lys Asp Ser Arg Trp Gly Asp Arg Asp Ser Glu 
                885                 890                 895     


Gly Thr Trp Arg Lys Gly Pro Glu Ala Asp Ser Glu Trp Arg Arg Gly 
            900                 905                 910         


Pro Pro Glu Lys Glu Trp Arg Arg Gly Glu Gly Arg Asp Glu Asp Arg 
        915                 920                 925             


Ser His Arg Arg Asp Glu Glu Arg Pro Arg Arg Leu Gly Asp Asp Glu 
    930                 935                 940                 


Asp Arg Glu Pro Ser Leu Arg Pro Asp Asp Asp Arg Val Pro Arg Arg 
945                 950                 955                 960 


Gly Met Asp Asp Asp Arg Gly Pro Arg Arg Gly Pro Glu Glu Asp Arg 
                965                 970                 975     


Phe Ser Arg Arg Gly Ala Asp Asp Asp Arg Pro Ser Trp Arg Asn Thr 
            980                 985                 990         


Asp Asp Asp Arg Pro Pro Arg Arg  Ile Ala Asp Glu Asp  Arg Gly Asn 
        995                 1000                 1005             


Trp Arg  His Ala Asp Asp Asp  Arg Pro Pro Arg Arg  Gly Leu Asp 
    1010                 1015                 1020             


Glu Asp  Arg Gly Ser Trp Arg  Thr Ala Asp Glu Asp  Arg Gly Pro 
    1025                 1030                 1035             


Arg Arg  Gly Met Asp Asp Asp  Arg Gly Pro Arg Arg  Gly Gly Ala 
    1040                 1045                 1050             


Asp Asp  Glu Arg Ser Ser Trp  Arg Asn Ala Asp Asp  Asp Arg Gly 
    1055                 1060                 1065             


Pro Arg  Arg Gly Leu Asp Asp  Asp Arg Gly Pro Arg  Arg Gly Met 
    1070                 1075                 1080             


Asp Asp  Asp Arg Gly Pro Arg  Arg Gly Met Asp Asp  Asp Arg Gly 
    1085                 1090                 1095             


Pro Arg  Arg Gly Met Asp Asp  Asp Arg Gly Pro Arg  Arg Gly Leu 
    1100                 1105                 1110             


Asp Asp  Asp Arg Gly Pro Trp  Arg Asn Ala Asp Asp  Asp Arg Ile 
    1115                 1120                 1125             


Pro Arg  Arg Gly Ala Glu Asp  Asp Arg Gly Pro Trp  Arg Asn Met 
    1130                 1135                 1140             


Asp Asp  Asp Arg Leu Ser Arg  Arg Ala Asp Asp Asp  Arg Phe Pro 
    1145                 1150                 1155             


Arg Arg  Gly Asp Asp Ser Arg  Pro Gly Pro Trp Arg  Pro Leu Val 
    1160                 1165                 1170             


Lys Pro  Gly Gly Trp Arg Glu  Lys Glu Lys Ala Arg  Glu Glu Ser 
    1175                 1180                 1185             


Trp Gly  Pro Pro Arg Glu Ser  Arg Pro Ser Glu Glu  Arg Glu Trp 
    1190                 1195                 1200             


Asp Arg  Glu Lys Glu Arg Asp  Arg Asp Asn Gln Asp  Arg Glu Glu 
    1205                 1210                 1215             


Asn Asp  Lys Asp Pro Glu Arg  Glu Arg Asp Arg Glu  Arg Asp Val 
    1220                 1225                 1230             


Asp Arg  Glu Asp Arg Phe Arg  Arg Pro Arg Asp Glu  Gly Gly Trp 
    1235                 1240                 1245             


Arg Arg  Gly Pro Ala Glu Glu  Ser Ser Ser Trp Arg  Asp Ser Ser 
    1250                 1255                 1260             


Arg Arg  Asp Asp Arg Asp Arg  Asp Asp Arg Arg Arg  Glu Arg Asp 
    1265                 1270                 1275             


Asp Arg  Arg Asp Leu Arg Glu  Arg Arg Asp Leu Arg  Asp Asp Arg 
    1280                 1285                 1290             


Asp Arg  Arg Gly Pro Pro Leu  Arg Ser Glu Arg Glu  Glu Val Ser 
    1295                 1300                 1305             


Ser Trp  Arg Arg Ala Asp Asp  Arg Lys Asp Asp Arg  Val Glu Glu 
    1310                 1315                 1320             


Arg Asp  Pro Pro Arg Arg Val  Pro Pro Pro Ala Leu  Ser Arg Asp 
    1325                 1330                 1335             


Arg Glu  Arg Asp Arg Asp Arg  Glu Arg Glu Gly Glu  Lys Glu Lys 
    1340                 1345                 1350             


Ala Ser  Trp Arg Ala Glu Lys  Asp Arg Glu Ser Leu  Arg Arg Thr 
    1355                 1360                 1365             


Lys Asn  Glu Thr Asp Glu Asp  Gly Trp Thr Thr Val  Arg Arg 
    1370                 1375                 1380         


<210>  149
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Ser Pro Thr Pro Pro Leu Phe Ser Leu Pro Glu Ala Arg Thr Arg 
1               5                   10                  15      


Phe Thr Lys Ser Thr Arg Glu Ala Leu Asn Asn Lys Asn Ile Lys Pro 
            20                  25                  30          


Leu Leu Ser Thr Phe Ser Gln Val Pro Gly Ser Glu Asn Glu Lys Lys 
        35                  40                  45              


Cys Thr Leu Asp Gln Ala Phe Arg Gly Ile Leu Glu Glu Glu Ile Ile 
    50                  55                  60                  


Asn His Ser Ser Cys Glu Asn Val Leu Ala Ile Ile Ser Leu Ala Ile 
65                  70                  75                  80  


Gly Gly Val Thr Glu Gly Ile Cys Thr Ala Ser Thr Pro Phe Val Leu 
                85                  90                  95      


Leu Gly Asp Val Leu Asp Cys Leu Pro Leu Asp Gln Cys Asp Thr Ile 
            100                 105                 110         


Phe Thr Phe Val Glu Lys Asn Val Ala Thr Trp Lys Ser Asn Thr Phe 
        115                 120                 125             


Tyr Ser Ala Gly Lys Asn Tyr Leu Leu Arg Met Cys Asn Asp Leu Leu 
    130                 135                 140                 


Arg Arg Leu Ser Lys Ser Gln Asn Thr Val Phe Cys Gly Arg Ile Gln 
145                 150                 155                 160 


Leu Phe Leu Ala Arg Leu Phe Pro Leu Ser Glu Lys Ser Gly Leu Asn 
                165                 170                 175     


Leu Gln Ser Gln Phe Asn Leu Glu Asn Val Thr Val Phe Asn Thr Asn 
            180                 185                 190         


Glu Gln Glu Ser Thr Leu Gly Gln Lys His Thr Glu Asp Arg Glu Glu 
        195                 200                 205             


Gly Met Asp Val Glu Glu Gly Glu Met Gly Asp Glu Glu Ala Pro Thr 
    210                 215                 220                 


Thr Cys Ser Ile Pro Ile Asp Tyr Asn Leu Tyr Arg Lys Phe Trp Ser 
225                 230                 235                 240 


Leu Gln Asp Tyr Phe Arg Asn Pro Val Gln Cys Tyr Glu Lys Ile Ser 
                245                 250                 255     


Trp Lys Thr Phe Leu Lys Tyr Ser Glu Glu Val Leu Ala Val Phe Lys 
            260                 265                 270         


Ser Tyr Lys Leu Asp Asp Thr Gln Ala Ser Arg Lys Lys Met Glu Glu 
        275                 280                 285             


Leu Lys Thr Gly Gly Glu His Val Tyr Phe Ala Lys Phe Leu Thr Ser 
    290                 295                 300                 


Glu Lys Leu Met Asp Leu Gln Leu Ser Asp Ser Asn Phe Arg Arg His 
305                 310                 315                 320 


Ile Leu Leu Gln Tyr Leu Ile Leu Phe Gln Tyr Leu Lys Gly Gln Val 
                325                 330                 335     


Lys Phe Lys Ser Ser Asn Tyr Val Leu Thr Asp Glu Gln Ser Leu Trp 
            340                 345                 350         


Ile Glu Asp Thr Thr Lys Ser Val Tyr Gln Leu Leu Ser Glu Asn Pro 
        355                 360                 365             


Pro Asp Gly Glu Arg Phe Ser Lys Met Val Glu His Ile Leu Asn Thr 
    370                 375                 380                 


Glu Glu Asn Trp Asn Ser Trp Lys Asn Glu Gly Cys Pro Ser Phe Val 
385                 390                 395                 400 


Lys Glu Arg Thr Ser Asp Thr Lys Pro Thr Arg Ile Ile Arg Lys Arg 
                405                 410                 415     


Thr Ala Pro Glu Asp Phe Leu Gly Lys Gly Pro Thr Lys Lys Ile Leu 
            420                 425                 430         


Met Gly Asn Glu Glu Leu Thr Arg Leu Trp Asn Leu Cys Pro Asp Asn 
        435                 440                 445             


Met Glu Ala Cys Lys Ser Glu Thr Arg Glu His Met Pro Thr Leu Glu 
    450                 455                 460                 


Glu Phe Phe Glu Glu Ala Ile Glu Gln Ala Asp Pro Glu Asn Met Val 
465                 470                 475                 480 


Glu Asn Glu Tyr Lys Ala Val Asn Asn Ser Asn Tyr Gly Trp Arg Ala 
                485                 490                 495     


Leu Arg Leu Leu Ala Arg Arg Ser Pro His Phe Phe Gln Pro Thr Asn 
            500                 505                 510         


Gln Gln Phe Lys Ser Leu Pro Glu Tyr Leu Glu Asn Met Val Ile Lys 
        515                 520                 525             


Leu Ala Lys Glu Leu Pro Pro Pro Ser Glu Glu Ile Lys Thr Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Glu Asp Asn Asp Ala Leu Leu Lys Glu Asn Glu Ser 
545                 550                 555                 560 


Pro Asp Val Arg Arg Asp Lys Pro Val Thr Gly Glu Gln Ile Glu Val 
                565                 570                 575     


Phe Ala Asn Lys Leu Gly Glu Gln Trp Lys Ile Leu Ala Pro Tyr Leu 
            580                 585                 590         


Glu Met Lys Asp Ser Glu Ile Arg Gln Ile Glu Cys Asp Ser Glu Asp 
        595                 600                 605             


Met Lys Met Arg Ala Lys Gln Leu Leu Val Ala Trp Gln Asp Gln Glu 
    610                 615                 620                 


Gly Val His Ala Thr Pro Glu Asn Leu Ile Asn Ala Leu Asn Lys Ser 
625                 630                 635                 640 


Gly Leu Ser Asp Leu Ala Glu Ser Leu Thr Asn Asp Asn Glu Thr Asn 
                645                 650                 655     


Ser 
    


<210>  150
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ala Thr Pro Ala Val Pro Val Ser Ala Pro Pro Ala Thr Pro Thr 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Pro Ala Ser Val Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ala Ala Pro Val Pro Ala Ala Ala Pro Ala Ser Ser Ser Asp 
        35                  40                  45              


Pro Ala Ala Ala Ala Ala Ala Thr Ala Ala Pro Gly Gln Thr Pro Ala 
    50                  55                  60                  


Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro Ala Leu Pro Gly Pro 
65                  70                  75                  80  


Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val Arg Leu His Pro 
                85                  90                  95      


Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg Arg Asn Glu Gly 
            100                 105                 110         


Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val Asp Lys His Ser 
        115                 120                 125             


Val Glu Val Thr Asn Cys Phe Ser Val Pro His Asn Glu Ser Glu Asp 
    130                 135                 140                 


Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn Met Tyr Glu Leu His 
145                 150                 155                 160 


Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp Tyr Ala Thr Gly 
                165                 170                 175     


His Asp Ile Thr Glu His Ser Val Leu Ile His Glu Tyr Tyr Ser Arg 
            180                 185                 190         


Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr Ser Leu Gln Asn 
        195                 200                 205             


Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu Met Gly Val Pro 
    210                 215                 220                 


Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr Val Lys Tyr Ala 
225                 230                 235                 240 


Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile Met Lys Thr Cys 
                245                 250                 255     


Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp Leu Gln Gln Val 
            260                 265                 270         


Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser Thr Val Leu Gln 
        275                 280                 285             


Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala Asp Asn Thr Val 
    290                 295                 300                 


Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro Lys Ile Val Pro 
305                 310                 315                 320 


Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn Asp Leu Leu Met 
                325                 330                 335     


Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu 
            340                 345                 350         


Lys Leu Val Asn Leu 
        355         


<210>  151
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Arg Arg Ala Glu Leu Ala Gly Leu Lys Thr Met Ala Trp Val Pro 
1               5                   10                  15      


Ala Glu Ser Ala Val Glu Glu Leu Met Pro Arg Leu Leu Pro Val Glu 
            20                  25                  30          


Pro Cys Asp Leu Thr Glu Gly Phe Asp Pro Ser Val Pro Pro Arg Thr 
        35                  40                  45              


Pro Gln Glu Tyr Leu Arg Arg Val Gln Ile Glu Ala Ala Gln Cys Pro 
    50                  55                  60                  


Asp Val Val Val Ala Gln Ile Asp Pro Lys Lys Leu Lys Arg Lys Gln 
65                  70                  75                  80  


Ser Val Asn Ile Ser Leu Ser Gly Cys Gln Pro Ala Pro Glu Gly Tyr 
                85                  90                  95      


Ser Pro Thr Leu Gln Trp Gln Gln Gln Gln Val Ala Gln Phe Ser Thr 
            100                 105                 110         


Val Arg Gln Asn Val Asn Lys His Arg Ser His Trp Lys Ser Gln Gln 
        115                 120                 125             


Leu Asp Ser Asn Val Thr Met Pro Lys Ser Glu Asp Glu Glu Gly Trp 
    130                 135                 140                 


Lys Lys Phe Cys Leu Gly Glu Lys Leu Cys Ala Asp Gly Ala Val Gly 
145                 150                 155                 160 


Pro Ala Thr Asn Glu Ser Pro Gly Ile Asp Tyr Val Gln Ile Gly Phe 
                165                 170                 175     


Pro Pro Leu Leu Ser Ile Val Ser Arg Met Asn Gln Ala Thr Val Thr 
            180                 185                 190         


Ser Val Leu Glu Tyr Leu Ser Asn Trp Phe Gly Glu Arg Asp Phe Thr 
        195                 200                 205             


Pro Glu Leu Gly Arg Trp Leu Tyr Ala Leu Leu Ala Cys Leu Glu Lys 
    210                 215                 220                 


Pro Leu Leu Pro Glu Ala His Ser Leu Ile Arg Gln Leu Ala Arg Arg 
225                 230                 235                 240 


Cys Ser Glu Val Arg Leu Leu Val Asp Ser Lys Asp Asp Glu Arg Val 
                245                 250                 255     


Pro Ala Leu Asn Leu Leu Ile Cys Leu Val Ser Arg Tyr Phe Asp Gln 
            260                 265                 270         


Arg Asp Leu Ala Asp Glu Pro Ser 
        275                 280 


<210>  152
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Glu Glu Ile Tyr Ala Lys Phe Val Ser Gln Lys Ile Ser Lys Thr 
1               5                   10                  15      


Arg Trp Arg Pro Leu Pro Pro Gly Ser Leu Gln Thr Ala Glu Thr Phe 
            20                  25                  30          


Ala Thr Gly Ser Trp Asp Asn Glu Glu Asn Tyr Ile Ser Leu Trp Ser 
        35                  40                  45              


Ile Gly Asp Phe Gly Asn Leu Asp Ser Asp Gly Gly Phe Glu Gly Asp 
    50                  55                  60                  


His Gln Leu Leu Cys Asp Ile Arg His His Gly Asp Val Met Asp Leu 
65                  70                  75                  80  


Gln Phe Phe Asp Gln Glu Arg Ile Val Ala Ala Ser Ser Thr Gly Cys 
                85                  90                  95      


Val Thr Val Phe Leu His His Pro Asn Asn Gln Thr Leu Ser Val Asn 
            100                 105                 110         


Gln Gln Trp Thr Thr Ala His Tyr His Thr Gly Pro Gly Ser Pro Ser 
        115                 120                 125             


Tyr Ser Ser Ala Pro Cys Thr Gly Val Val Cys Asn Asn Pro Glu Ile 
    130                 135                 140                 


Val Thr Val Gly Glu Asp Gly Arg Ile Asn Leu Phe Arg Ala Asp His 
145                 150                 155                 160 


Lys Glu Ala Val Arg Thr Ile Asp Asn Ala Asp Ser Ser Thr Leu His 
                165                 170                 175     


Ala Val Thr Phe Leu Arg Thr Pro Glu Ile Leu Thr Val Asn Ser Ile 
            180                 185                 190         


Gly Gln Leu Lys Ile Trp Asp Phe Arg Gln Gln Gly Asn Glu Pro Ser 
        195                 200                 205             


Gln Ile Leu Ser Leu Thr Gly Asp Arg Val Pro Leu His Cys Val Asp 
    210                 215                 220                 


Arg His Pro Asn Gln Gln His Val Val Ala Thr Gly Gly Gln Asp Gly 
225                 230                 235                 240 


Met Leu Ser Ile Trp Asp Val Arg Gln Gly Thr Met Pro Val Ser Leu 
                245                 250                 255     


Leu Lys Ala His Glu Ala Glu Met Trp Glu Val His Phe His Pro Ser 
            260                 265                 270         


Asn Pro Glu His Leu Phe Thr Cys Ser Glu Asp Gly Ser Leu Trp His 
        275                 280                 285             


Trp Asp Ala Ser Thr Asp Val Pro Glu Lys Ser Ser Leu Phe His Gln 
    290                 295                 300                 


Gly Gly Arg Ser Ser Thr Phe Leu Ser His Ser Ile Ser Asn Gln Ala 
305                 310                 315                 320 


Asn Val His Gln Ser Val Ile Ser Ser Trp Leu Ser Thr Asp Pro Ala 
                325                 330                 335     


Lys Asp Arg Ile Glu Ile Thr Ser Leu Leu Pro Ser Arg Ser Leu Ser 
            340                 345                 350         


Val Asn Thr Leu Asp Val Leu Gly Pro Cys Leu Val Cys Gly Thr Asp 
        355                 360                 365             


Ala Glu Ala Ile Tyr Val Thr Arg His Leu Phe Ser 
    370                 375                 380 


<210>  153
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Glu Ala Ala Gly Ser Pro Ala Ala Thr Glu Thr Gly Lys Tyr Ile 
1               5                   10                  15      


Ala Ser Thr Gln Arg Pro Asp Gly Thr Trp Arg Lys Gln Arg Arg Val 
            20                  25                  30          


Lys Glu Gly Tyr Val Pro Gln Glu Glu Val Pro Val Tyr Glu Asn Lys 
        35                  40                  45              


Tyr Val Lys Phe Phe Lys Ser Lys Pro Glu Leu Pro Pro Gly Leu Ser 
    50                  55                  60                  


Pro Glu Ala Thr Ala Pro Val Thr Pro Ser Arg Pro Glu Gly Gly Glu 
65                  70                  75                  80  


Pro Gly Leu Ser Lys Thr Ala Lys Arg Asn Leu Lys Arg Lys Glu Lys 
                85                  90                  95      


Arg Arg Gln Gln Gln Glu Lys Gly Glu Ala Glu Ala Leu Ser Arg Thr 
            100                 105                 110         


Leu Asp Lys Val Ser Leu Glu Glu Thr Ala Gln Leu Pro Ser Ala Pro 
        115                 120                 125             


Gln Gly Ser Arg Ala Ala Pro Thr Ala Ala Ser Asp Gln Pro Asp Ser 
    130                 135                 140                 


Ala Ala Thr Thr Glu Lys Ala Lys Lys Ile Lys Asn Leu Lys Lys Lys 
145                 150                 155                 160 


Leu Arg Gln Val Glu Glu Leu Gln Gln Arg Ile Gln Ala Gly Glu Val 
                165                 170                 175     


Ser Gln Pro Ser Lys Glu Gln Leu Glu Lys Leu Ala Arg Arg Arg Ala 
            180                 185                 190         


Leu Glu Glu Glu Leu Glu Asp Leu Glu Leu Gly Leu 
        195                 200                 


<210>  154
<211>  1129
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ser Val Glu Ala Tyr Gly Pro Ser Ser Gln Thr Leu Thr Phe Leu 
1               5                   10                  15      


Asp Thr Glu Glu Ala Glu Leu Leu Gly Ala Asp Thr Gln Gly Ser Glu 
            20                  25                  30          


Phe Glu Phe Thr Asp Phe Thr Leu Pro Ser Gln Thr Gln Thr Pro Pro 
        35                  40                  45              


Gly Gly Pro Gly Gly Pro Gly Gly Gly Gly Ala Gly Gly Pro Gly Gly 
    50                  55                  60                  


Ala Gly Ala Gly Ala Ala Ala Gly Gln Leu Asp Ala Gln Val Gly Pro 
65                  70                  75                  80  


Glu Gly Ile Leu Gln Asn Gly Ala Val Asp Asp Ser Val Ala Lys Thr 
                85                  90                  95      


Ser Gln Leu Leu Ala Glu Leu Asn Phe Glu Glu Asp Glu Glu Asp Thr 
            100                 105                 110         


Tyr Tyr Thr Lys Asp Leu Pro Ile His Ala Cys Ser Tyr Cys Gly Ile 
        115                 120                 125             


His Asp Pro Ala Cys Val Val Tyr Cys Asn Thr Ser Lys Lys Trp Phe 
    130                 135                 140                 


Cys Asn Gly Arg Gly Asn Thr Ser Gly Ser His Ile Val Asn His Leu 
145                 150                 155                 160 


Val Arg Ala Lys Cys Lys Glu Val Thr Leu His Lys Asp Gly Pro Leu 
                165                 170                 175     


Gly Glu Thr Val Leu Glu Cys Tyr Asn Cys Gly Cys Arg Asn Val Phe 
            180                 185                 190         


Leu Leu Gly Phe Ile Pro Ala Lys Ala Asp Ser Val Val Val Leu Leu 
        195                 200                 205             


Cys Arg Gln Pro Cys Ala Ser Gln Ser Ser Leu Lys Asp Ile Asn Trp 
    210                 215                 220                 


Asp Ser Ser Gln Trp Gln Pro Leu Ile Gln Asp Arg Cys Phe Leu Ser 
225                 230                 235                 240 


Trp Leu Val Lys Ile Pro Ser Glu Gln Glu Gln Leu Arg Ala Arg Gln 
                245                 250                 255     


Ile Thr Ala Gln Gln Ile Asn Lys Leu Glu Glu Leu Trp Lys Glu Asn 
            260                 265                 270         


Pro Ser Ala Thr Leu Glu Asp Leu Glu Lys Pro Gly Val Asp Glu Glu 
        275                 280                 285             


Pro Gln His Val Leu Leu Arg Tyr Glu Asp Ala Tyr Gln Tyr Gln Asn 
    290                 295                 300                 


Ile Phe Gly Pro Leu Val Lys Leu Glu Ala Asp Tyr Asp Lys Lys Leu 
305                 310                 315                 320 


Lys Glu Ser Gln Thr Gln Asp Asn Ile Thr Val Arg Trp Asp Leu Gly 
                325                 330                 335     


Leu Asn Lys Lys Arg Ile Ala Tyr Phe Thr Leu Pro Lys Thr Asp Ser 
            340                 345                 350         


Gly Asn Glu Asp Leu Val Ile Ile Trp Leu Arg Asp Met Arg Leu Met 
        355                 360                 365             


Gln Gly Asp Glu Ile Cys Leu Arg Tyr Lys Gly Asp Leu Ala Pro Leu 
    370                 375                 380                 


Trp Lys Gly Ile Gly His Val Ile Lys Val Pro Asp Asn Tyr Gly Asp 
385                 390                 395                 400 


Glu Ile Ala Ile Glu Leu Arg Ser Ser Val Gly Ala Pro Val Glu Val 
                405                 410                 415     


Thr His Asn Phe Gln Val Asp Phe Val Trp Lys Ser Thr Ser Phe Asp 
            420                 425                 430         


Arg Met Gln Ser Ala Leu Lys Thr Phe Ala Val Asp Glu Thr Ser Val 
        435                 440                 445             


Ser Gly Tyr Ile Tyr His Lys Leu Leu Gly His Glu Val Glu Asp Val 
    450                 455                 460                 


Ile Ile Lys Cys Gln Leu Pro Lys Arg Phe Thr Ala Gln Gly Leu Pro 
465                 470                 475                 480 


Asp Leu Asn His Ser Gln Val Tyr Ala Val Lys Thr Val Leu Gln Arg 
                485                 490                 495     


Pro Leu Ser Leu Ile Gln Gly Pro Pro Gly Thr Gly Lys Thr Val Thr 
            500                 505                 510         


Ser Ala Thr Ile Val Tyr His Leu Ala Arg Gln Gly Asn Gly Pro Val 
        515                 520                 525             


Leu Val Cys Ala Pro Ser Asn Ile Ala Val Asp Gln Leu Thr Glu Lys 
    530                 535                 540                 


Ile His Gln Thr Gly Leu Lys Val Val Arg Leu Cys Ala Lys Ser Arg 
545                 550                 555                 560 


Glu Ala Ile Asp Ser Pro Val Ser Phe Leu Ala Leu His Asn Gln Ile 
                565                 570                 575     


Arg Asn Met Asp Ser Met Pro Glu Leu Gln Lys Leu Gln Gln Leu Lys 
            580                 585                 590         


Asp Glu Thr Gly Glu Leu Ser Ser Ala Asp Glu Lys Arg Tyr Arg Ala 
        595                 600                 605             


Leu Lys Arg Thr Ala Glu Arg Glu Leu Leu Met Asn Ala Asp Val Ile 
    610                 615                 620                 


Cys Cys Thr Cys Val Gly Ala Gly Asp Pro Arg Leu Ala Lys Met Gln 
625                 630                 635                 640 


Phe Arg Ser Ile Leu Ile Asp Glu Ser Thr Gln Ala Thr Glu Pro Glu 
                645                 650                 655     


Cys Met Val Pro Val Val Leu Gly Ala Lys Gln Leu Ile Leu Val Gly 
            660                 665                 670         


Asp His Cys Gln Leu Gly Pro Val Val Met Cys Lys Lys Ala Ala Lys 
        675                 680                 685             


Ala Gly Leu Ser Gln Ser Leu Phe Glu Arg Leu Val Val Leu Gly Ile 
    690                 695                 700                 


Arg Pro Ile Arg Leu Gln Val Gln Tyr Arg Met His Pro Ala Leu Ser 
705                 710                 715                 720 


Ala Phe Pro Ser Asn Ile Phe Tyr Glu Gly Ser Leu Gln Asn Gly Val 
                725                 730                 735     


Thr Ala Ala Asp Arg Val Lys Lys Gly Phe Asp Phe Gln Trp Pro Gln 
            740                 745                 750         


Pro Asp Lys Pro Met Phe Phe Tyr Val Thr Gln Gly Gln Glu Glu Ile 
        755                 760                 765             


Ala Ser Ser Gly Thr Ser Tyr Leu Asn Arg Thr Glu Ala Ala Asn Val 
    770                 775                 780                 


Glu Lys Ile Thr Thr Lys Leu Leu Lys Ala Gly Ala Lys Pro Asp Gln 
785                 790                 795                 800 


Ile Gly Ile Ile Thr Pro Tyr Glu Gly Gln Arg Ser Tyr Leu Val Gln 
                805                 810                 815     


Tyr Met Gln Phe Ser Gly Ser Leu His Thr Lys Leu Tyr Gln Glu Val 
            820                 825                 830         


Glu Ile Ala Ser Val Asp Ala Phe Gln Gly Arg Glu Lys Asp Phe Ile 
        835                 840                 845             


Ile Leu Ser Cys Val Arg Ala Asn Glu His Gln Gly Ile Gly Phe Leu 
    850                 855                 860                 


Asn Asp Pro Arg Arg Leu Asn Val Ala Leu Thr Arg Ala Arg Tyr Gly 
865                 870                 875                 880 


Val Ile Ile Val Gly Asn Pro Lys Ala Leu Ser Lys Gln Pro Leu Trp 
                885                 890                 895     


Asn His Leu Leu Asn Tyr Tyr Lys Glu Gln Lys Val Leu Val Glu Gly 
            900                 905                 910         


Pro Leu Asn Asn Leu Arg Glu Ser Leu Met Gln Phe Ser Lys Pro Arg 
        915                 920                 925             


Lys Leu Val Asn Thr Ile Asn Pro Gly Ala Arg Phe Met Thr Thr Ala 
    930                 935                 940                 


Met Tyr Asp Ala Arg Glu Ala Ile Ile Pro Gly Ser Val Tyr Asp Arg 
945                 950                 955                 960 


Ser Ser Gln Gly Arg Pro Ser Ser Met Tyr Phe Gln Thr His Asp Gln 
                965                 970                 975     


Ile Gly Met Ile Ser Ala Gly Pro Ser His Val Ala Ala Met Asn Ile 
            980                 985                 990         


Pro Ile Pro Phe Asn Leu Val Met  Pro Pro Met Pro Pro  Pro Gly Tyr 
        995                 1000                 1005             


Phe Gly  Gln Ala Asn Gly Pro  Ala Ala Gly Arg Gly  Thr Pro Lys 
    1010                 1015                 1020             


Gly Lys  Thr Gly Arg Gly Gly  Arg Gln Lys Asn Arg  Phe Gly Leu 
    1025                 1030                 1035             


Pro Gly  Pro Ser Gln Thr Asn  Leu Pro Asn Ser Gln  Ala Ser Gln 
    1040                 1045                 1050             


Asp Val  Ala Ser Gln Pro Phe  Ser Gln Gly Ala Leu  Thr Gln Gly 
    1055                 1060                 1065             


Tyr Ile  Ser Met Ser Gln Pro  Ser Gln Met Ser Gln  Pro Gly Leu 
    1070                 1075                 1080             


Ser Gln  Pro Glu Leu Ser Gln  Asp Ser Tyr Leu Gly  Asp Glu Phe 
    1085                 1090                 1095             


Lys Ser  Gln Ile Asp Val Ala  Leu Ser Gln Asp Ser  Thr Tyr Gln 
    1100                 1105                 1110             


Gly Glu  Arg Ala Tyr Gln His  Gly Gly Val Thr Gly  Leu Ser Gln 
    1115                 1120                 1125             


Tyr 
    


<210>  155
<211>  1071
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Pro Ala Ile Met Thr Met Leu Ala Asp His Ala Ala Arg Gln Leu 
1               5                   10                  15      


Leu Asp Phe Ser Gln Lys Leu Asp Ile Asn Leu Leu Asp Asn Val Val 
            20                  25                  30          


Asn Cys Leu Tyr His Gly Glu Gly Ala Gln Gln Arg Met Ala Gln Glu 
        35                  40                  45              


Val Leu Thr His Leu Lys Glu His Pro Asp Ala Trp Thr Arg Val Asp 
    50                  55                  60                  


Thr Ile Leu Glu Phe Ser Gln Asn Met Asn Thr Lys Tyr Tyr Gly Leu 
65                  70                  75                  80  


Gln Ile Leu Glu Asn Val Ile Lys Thr Arg Trp Lys Ile Leu Pro Arg 
                85                  90                  95      


Asn Gln Cys Glu Gly Ile Lys Lys Tyr Val Val Gly Leu Ile Ile Lys 
            100                 105                 110         


Thr Ser Ser Asp Pro Thr Cys Val Glu Lys Glu Lys Val Tyr Ile Gly 
        115                 120                 125             


Lys Leu Asn Met Ile Leu Val Gln Ile Leu Lys Gln Glu Trp Pro Lys 
    130                 135                 140                 


His Trp Pro Thr Phe Ile Ser Asp Ile Val Gly Ala Ser Arg Thr Ser 
145                 150                 155                 160 


Glu Ser Leu Cys Gln Asn Asn Met Val Ile Leu Lys Leu Leu Ser Glu 
                165                 170                 175     


Glu Val Phe Asp Phe Ser Ser Gly Gln Ile Thr Gln Val Lys Ser Lys 
            180                 185                 190         


His Leu Lys Asp Ser Met Cys Asn Glu Phe Ser Gln Ile Phe Gln Leu 
        195                 200                 205             


Cys Gln Phe Val Met Glu Asn Ser Gln Asn Ala Pro Leu Val His Ala 
    210                 215                 220                 


Thr Leu Glu Thr Leu Leu Arg Phe Leu Asn Trp Ile Pro Leu Gly Tyr 
225                 230                 235                 240 


Ile Phe Glu Thr Lys Leu Ile Ser Thr Leu Ile Tyr Lys Phe Leu Asn 
                245                 250                 255     


Val Pro Met Phe Arg Asn Val Ser Leu Lys Cys Leu Thr Glu Ile Ala 
            260                 265                 270         


Gly Val Ser Val Ser Gln Tyr Glu Glu Gln Phe Val Thr Leu Phe Thr 
        275                 280                 285             


Leu Thr Met Met Gln Leu Lys Gln Met Leu Pro Leu Asn Thr Asn Ile 
    290                 295                 300                 


Arg Leu Ala Tyr Ser Asn Gly Lys Asp Asp Glu Gln Asn Phe Ile Gln 
305                 310                 315                 320 


Asn Leu Ser Leu Phe Leu Cys Thr Phe Leu Lys Glu His Asp Gln Leu 
                325                 330                 335     


Ile Glu Lys Arg Leu Asn Leu Arg Glu Thr Leu Met Glu Ala Leu His 
            340                 345                 350         


Tyr Met Leu Leu Val Ser Glu Val Glu Glu Thr Glu Ile Phe Lys Ile 
        355                 360                 365             


Cys Leu Glu Tyr Trp Asn His Leu Ala Ala Glu Leu Tyr Arg Glu Ser 
    370                 375                 380                 


Pro Phe Ser Thr Ser Ala Ser Pro Leu Leu Ser Gly Ser Gln His Phe 
385                 390                 395                 400 


Asp Val Pro Pro Arg Arg Gln Leu Tyr Leu Pro Met Leu Phe Lys Val 
                405                 410                 415     


Arg Leu Leu Met Val Ser Arg Met Ala Lys Pro Glu Glu Val Leu Val 
            420                 425                 430         


Val Glu Asn Asp Gln Gly Glu Val Val Arg Glu Phe Met Lys Asp Thr 
        435                 440                 445             


Asp Ser Ile Asn Leu Tyr Lys Asn Met Arg Glu Thr Leu Val Tyr Leu 
    450                 455                 460                 


Thr His Leu Asp Tyr Val Asp Thr Glu Arg Ile Met Thr Glu Lys Leu 
465                 470                 475                 480 


His Asn Gln Val Asn Gly Thr Glu Trp Ser Trp Lys Asn Leu Asn Thr 
                485                 490                 495     


Leu Cys Trp Ala Ile Gly Ser Ile Ser Gly Ala Met His Glu Glu Asp 
            500                 505                 510         


Glu Lys Arg Phe Leu Val Thr Val Ile Lys Asp Leu Leu Gly Leu Cys 
        515                 520                 525             


Glu Gln Lys Arg Gly Lys Asp Asn Lys Ala Ile Ile Ala Ser Asn Ile 
    530                 535                 540                 


Met Tyr Ile Val Gly Gln Tyr Pro Arg Phe Leu Arg Ala His Trp Lys 
545                 550                 555                 560 


Phe Leu Lys Thr Val Val Asn Lys Leu Phe Glu Phe Met His Glu Thr 
                565                 570                 575     


His Asp Gly Val Gln Asp Met Ala Cys Asp Thr Phe Ile Lys Ile Ala 
            580                 585                 590         


Gln Lys Cys Arg Arg His Phe Val Gln Val Gln Val Gly Glu Val Met 
        595                 600                 605             


Pro Phe Ile Asp Glu Ile Leu Asn Asn Ile Asn Thr Ile Ile Cys Asp 
    610                 615                 620                 


Leu Gln Pro Gln Gln Val His Thr Phe Tyr Glu Ala Val Gly Tyr Met 
625                 630                 635                 640 


Ile Gly Ala Gln Thr Asp Gln Thr Val Gln Glu His Leu Ile Glu Lys 
                645                 650                 655     


Tyr Met Leu Leu Pro Asn Gln Val Trp Asp Ser Ile Ile Gln Gln Ala 
            660                 665                 670         


Thr Lys Asn Val Asp Ile Leu Lys Asp Pro Glu Thr Val Lys Gln Leu 
        675                 680                 685             


Gly Ser Ile Leu Lys Thr Asn Val Arg Ala Cys Lys Ala Val Gly His 
    690                 695                 700                 


Pro Phe Val Ile Gln Leu Gly Arg Ile Tyr Leu Asp Met Leu Asn Val 
705                 710                 715                 720 


Tyr Lys Cys Leu Ser Glu Asn Ile Ser Ala Ala Ile Gln Ala Asn Gly 
                725                 730                 735     


Glu Met Val Thr Lys Gln Pro Leu Ile Arg Ser Met Arg Thr Val Lys 
            740                 745                 750         


Arg Glu Thr Leu Lys Leu Ile Ser Gly Trp Val Ser Arg Ser Asn Asp 
        755                 760                 765             


Pro Gln Met Val Ala Glu Asn Phe Val Pro Pro Leu Leu Asp Ala Val 
    770                 775                 780                 


Leu Ile Asp Tyr Gln Arg Asn Val Pro Ala Ala Arg Glu Pro Glu Val 
785                 790                 795                 800 


Leu Ser Thr Met Ala Ile Ile Val Asn Lys Leu Gly Gly His Ile Thr 
                805                 810                 815     


Ala Glu Ile Pro Gln Ile Phe Asp Ala Val Phe Glu Cys Thr Leu Asn 
            820                 825                 830         


Met Ile Asn Lys Asp Phe Glu Glu Tyr Pro Glu His Arg Thr Asn Phe 
        835                 840                 845             


Phe Leu Leu Leu Gln Ala Val Asn Ser His Cys Phe Pro Ala Phe Leu 
    850                 855                 860                 


Ala Ile Pro Pro Thr Gln Phe Lys Leu Val Leu Asp Ser Ile Ile Trp 
865                 870                 875                 880 


Ala Phe Lys His Thr Met Arg Asn Val Ala Asp Thr Gly Leu Gln Ile 
                885                 890                 895     


Leu Phe Thr Leu Leu Gln Asn Val Ala Gln Glu Glu Ala Ala Ala Gln 
            900                 905                 910         


Ser Phe Tyr Gln Thr Tyr Phe Cys Asp Ile Leu Gln His Ile Phe Ser 
        915                 920                 925             


Val Val Thr Asp Thr Ser His Thr Ala Gly Leu Thr Met His Ala Ser 
    930                 935                 940                 


Ile Leu Ala Tyr Met Phe Asn Leu Val Glu Glu Gly Lys Ile Ser Thr 
945                 950                 955                 960 


Ser Leu Asn Pro Gly Asn Pro Val Asn Asn Gln Ile Phe Leu Gln Glu 
                965                 970                 975     


Tyr Val Ala Asn Leu Leu Lys Ser Ala Phe Pro His Leu Gln Asp Ala 
            980                 985                 990         


Gln Val Lys Leu Phe Val Thr Gly  Leu Phe Ser Leu Asn  Gln Asp Ile 
        995                 1000                 1005             


Pro Ala  Phe Lys Glu His Leu  Arg Asp Phe Leu Val  Gln Ile Lys 
    1010                 1015                 1020             


Glu Phe  Ala Gly Glu Asp Thr  Ser Asp Leu Phe Leu  Glu Glu Arg 
    1025                 1030                 1035             


Glu Ile  Ala Leu Arg Gln Ala  Asp Glu Glu Lys His  Lys Arg Gln 
    1040                 1045                 1050             


Met Ser  Val Pro Gly Ile Phe  Asn Pro His Glu Ile  Pro Glu Glu 
    1055                 1060                 1065             


Met Cys  Asp 
    1070     


<210>  156
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Asn Pro Ser Ala Pro Ser Tyr Pro Met Ala Ser Leu Tyr Val Gly 
1               5                   10                  15      


Asp Leu His Pro Asp Val Thr Glu Ala Met Leu Tyr Glu Lys Phe Ser 
            20                  25                  30          


Pro Ala Gly Pro Ile Leu Ser Ile Arg Val Cys Arg Asp Met Ile Thr 
        35                  40                  45              


Arg Arg Ser Leu Gly Tyr Ala Tyr Val Asn Phe Gln Gln Pro Ala Asp 
    50                  55                  60                  


Ala Glu Arg Ala Leu Asp Thr Met Asn Phe Asp Val Ile Lys Gly Lys 
65                  70                  75                  80  


Pro Val Arg Ile Met Trp Ser Gln Arg Asp Pro Ser Leu Arg Lys Ser 
                85                  90                  95      


Gly Val Gly Asn Ile Phe Ile Lys Asn Leu Asp Lys Ser Ile Asp Asn 
            100                 105                 110         


Lys Ala Leu Tyr Asp Thr Phe Ser Ala Phe Gly Asn Ile Leu Ser Cys 
        115                 120                 125             


Lys Val Val Cys Asp Glu Asn Gly Ser Lys Gly Tyr Gly Phe Val His 
    130                 135                 140                 


Phe Glu Thr Gln Glu Ala Ala Glu Arg Ala Ile Glu Lys Met Asn Gly 
145                 150                 155                 160 


Met Leu Leu Asn Asp Arg Lys Val Phe Val Gly Arg Phe Lys Ser Arg 
                165                 170                 175     


Lys Glu Arg Glu Ala Glu Leu Gly Ala Arg Ala Lys Glu Phe Thr Asn 
            180                 185                 190         


Val Tyr Ile Lys Asn Phe Gly Glu Asp Met Asp Asp Glu Arg Leu Lys 
        195                 200                 205             


Asp Leu Phe Gly Lys Phe Gly Pro Ala Leu Ser Val Lys Val Met Thr 
    210                 215                 220                 


Asp Glu Ser Gly Lys Ser Lys Gly Phe Gly Phe Val Ser Phe Glu Arg 
225                 230                 235                 240 


His Glu Asp Ala Gln Lys Ala Val Asp Glu Met Asn Gly Lys Glu Leu 
                245                 250                 255     


Asn Gly Lys Gln Ile Tyr Val Gly Arg Ala Gln Lys Lys Val Glu Arg 
            260                 265                 270         


Gln Thr Glu Leu Lys Arg Lys Phe Glu Gln Met Lys Gln Asp Arg Ile 
        275                 280                 285             


Thr Arg Tyr Gln Gly Val Asn Leu Tyr Val Lys Asn Leu Asp Asp Gly 
    290                 295                 300                 


Ile Asp Asp Glu Arg Leu Arg Lys Glu Phe Ser Pro Phe Gly Thr Ile 
305                 310                 315                 320 


Thr Ser Ala Lys Val Met Met Glu Gly Gly Arg Ser Lys Gly Phe Gly 
                325                 330                 335     


Phe Val Cys Phe Ser Ser Pro Glu Glu Ala Thr Lys Ala Val Thr Glu 
            340                 345                 350         


Met Asn Gly Arg Ile Val Ala Thr Lys Pro Leu Tyr Val Ala Leu Ala 
        355                 360                 365             


Gln Arg Lys Glu Glu Arg Gln Ala His Leu Thr Asn Gln Tyr Met Gln 
    370                 375                 380                 


Arg Met Ala Ser Val Arg Ala Val Pro Asn Pro Val Ile Asn Pro Tyr 
385                 390                 395                 400 


Gln Pro Ala Pro Pro Ser Gly Tyr Phe Met Ala Ala Ile Pro Gln Thr 
                405                 410                 415     


Gln Asn Arg Ala Ala Tyr Tyr Pro Pro Ser Gln Ile Ala Gln Leu Arg 
            420                 425                 430         


Pro Ser Pro Arg Trp Thr Ala Gln Gly Ala Arg Pro His Pro Phe Gln 
        435                 440                 445             


Asn Met Pro Gly Ala Ile Arg Pro Ala Ala Pro Arg Pro Pro Phe Ser 
    450                 455                 460                 


Thr Met Arg Pro Ala Ser Ser Gln Val Pro Arg Val Met Ser Thr Gln 
465                 470                 475                 480 


Arg Val Ala Asn Thr Ser Thr Gln Thr Met Gly Pro Arg Pro Ala Ala 
                485                 490                 495     


Ala Ala Ala Ala Ala Thr Pro Ala Val Arg Thr Val Pro Gln Tyr Lys 
            500                 505                 510         


Tyr Ala Ala Gly Val Arg Asn Pro Gln Gln His Leu Asn Ala Gln Pro 
        515                 520                 525             


Gln Val Thr Met Gln Gln Pro Ala Val His Val Gln Gly Gln Glu Pro 
    530                 535                 540                 


Leu Thr Ala Ser Met Leu Ala Ser Ala Pro Pro Gln Glu Gln Lys Gln 
545                 550                 555                 560 


Met Leu Gly Glu Arg Leu Phe Pro Leu Ile Gln Ala Met His Pro Thr 
                565                 570                 575     


Leu Ala Gly Lys Ile Thr Gly Met Leu Leu Glu Ile Asp Asn Ser Glu 
            580                 585                 590         


Leu Leu His Met Leu Glu Ser Pro Glu Ser Leu Arg Ser Lys Val Asp 
        595                 600                 605             


Glu Ala Val Ala Val Leu Gln Ala His Gln Ala Lys Glu Ala Ala Gln 
    610                 615                 620                 


Lys Ala Val Asn Ser Ala Thr Gly Val Pro Thr Val 
625                 630                 635     


<210>  157
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  158
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gln Thr Pro Val Asn Ile Pro Val Pro Val Leu Arg Leu Pro Arg 
1               5                   10                  15      


Gly Pro Asp Gly Phe Ser Arg Gly Phe Ala Pro Asp Gly Arg Arg Ala 
            20                  25                  30          


Pro Leu Arg Pro Glu Val Pro Glu Ile Gln Glu Cys Pro Ile Ala Gln 
        35                  40                  45              


Glu Ser Leu Glu Ser Gln Glu Gln Arg Ala Arg Ala Ala Leu Arg Glu 
    50                  55                  60                  


Arg Tyr Leu Arg Ser Leu Leu Ala Met Val Gly His Gln Val Ser Phe 
65                  70                  75                  80  


Thr Leu His Glu Gly Val Arg Val Ala Ala His Phe Gly Ala Thr Asp 
                85                  90                  95      


Leu Asp Val Ala Asn Phe Tyr Val Ser Gln Leu Gln Thr Pro Ile Gly 
            100                 105                 110         


Val Gln Ala Glu Ala Leu Leu Arg Cys Ser Asp Ile Ile Ser Tyr Thr 
        115                 120                 125             


Phe Lys Pro 
    130     


<210>  159
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Leu Arg Cys Leu Tyr His Trp His Arg Pro Val Leu Asn Arg Arg 
1               5                   10                  15      


Trp Ser Arg Leu Cys Leu Pro Lys Gln Tyr Leu Phe Thr Met Lys Leu 
            20                  25                  30          


Gln Ser Pro Glu Phe Gln Ser Leu Phe Thr Glu Gly Leu Lys Ser Leu 
        35                  40                  45              


Thr Glu Leu Phe Val Lys Glu Asn His Glu Leu Arg Ile Ala Gly Gly 
    50                  55                  60                  


Ala Val Arg Asp Leu Leu Asn Gly Val Lys Pro Gln Asp Ile Asp Phe 
65                  70                  75                  80  


Ala Thr Thr Ala Thr Pro Thr Gln Met Lys Glu Met Phe Gln Ser Ala 
                85                  90                  95      


Gly Ile Arg Met Ile Asn Asn Arg Gly Glu Lys His Gly Thr Ile Thr 
            100                 105                 110         


Ala Arg Leu His Glu Glu Asn Phe Glu Ile Thr Thr Leu Arg Ile Asp 
        115                 120                 125             


Val Thr Thr Asp Gly Arg His Ala Glu Val Glu Phe Thr Thr Asp Trp 
    130                 135                 140                 


Gln Lys Asp Ala Glu Arg Arg Asp Leu Thr Ile Asn Ser Met Phe Leu 
145                 150                 155                 160 


Gly Phe Asp Gly Thr Leu Phe Asp Tyr Phe Asn Gly Tyr Glu Asp Leu 
                165                 170                 175     


Lys Asn Lys Lys Val Arg Phe Val Gly His Ala Lys Gln Arg Ile Gln 
            180                 185                 190         


Glu Asp Tyr Leu Arg Ile Leu Arg Tyr Phe Arg Phe Tyr Gly Arg Ile 
        195                 200                 205             


Val Asp Lys Pro Gly Asp His Asp Pro Glu Thr Leu Glu Ala Ile Ala 
    210                 215                 220                 


Glu Asn Ala Lys Gly Leu Ala Gly Ile Ser Gly Glu Arg Ile Trp Val 
225                 230                 235                 240 


Glu Leu Lys Lys Ile Leu Val Gly Asn His Val Asn His Leu Ile His 
                245                 250                 255     


Leu Ile Tyr Asp Leu Asp Val Ala Pro Tyr Ile Gly Leu Pro Ala Asn 
            260                 265                 270         


Ala Ser Leu Glu Glu Phe Asp Lys Val Ser Lys Asn Val Asp Gly Phe 
        275                 280                 285             


Ser Pro Lys Pro Val Thr Leu Leu Ala Ser Leu Phe Lys Val Gln Asp 
    290                 295                 300                 


Asp Val Thr Lys Leu Asp Leu Arg Leu Lys Ile Ala Lys Glu Glu Lys 
305                 310                 315                 320 


Asn Leu Gly Leu Phe Ile Val Lys Asn Arg Lys Asp Leu Ile Lys Ala 
                325                 330                 335     


Thr Asp Ser Ser Asp Pro Leu Lys Pro Tyr Gln Asp Phe Ile Ile Asp 
            340                 345                 350         


Ser Arg Glu Pro Asp Ala Thr Thr Arg Val Cys Glu Leu Leu Lys Tyr 
        355                 360                 365             


Gln Gly Glu His Cys Leu Leu Lys Glu Met Gln Gln Trp Ser Ile Pro 
    370                 375                 380                 


Pro Phe Pro Val Ser Gly His Asp Ile Arg Lys Val Gly Ile Ser Ser 
385                 390                 395                 400 


Gly Lys Glu Ile Gly Ala Leu Leu Gln Gln Leu Arg Glu Gln Trp Lys 
                405                 410                 415     


Lys Ser Gly Tyr Gln Met Glu Lys Asp Glu Leu Leu Ser Tyr Ile Lys 
            420                 425                 430         


Lys Thr 
        


<210>  160
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Thr Ala Val Ser Arg Pro Cys Ala Gly Arg Ser Arg Asp Ile 
1               5                   10                  15      


Leu Trp Arg Val Leu Gly Trp Arg Ile Val Ala Ser Ile Val Trp Ser 
            20                  25                  30          


Val Leu Phe Leu Pro Ile Cys Thr Thr Val Phe Ile Ile Phe Ser Arg 
        35                  40                  45              


Ile Asp Leu Phe His Pro Ile Gln Trp Leu Ser Asp Ser Phe Ser Asp 
    50                  55                  60                  


Leu Tyr Ser Ser Tyr Val Ile Phe Tyr Phe Leu Leu Leu Ser Val Val 
65                  70                  75                  80  


Ile Ile Ile Ile Ser Ile Phe Asn Val Glu Phe Tyr Ala Val Val Pro 
                85                  90                  95      


Ser Ile Pro Cys Ser Arg Leu Ala Leu Ile Gly Lys Ile Ile His Pro 
            100                 105                 110         


Gln Gln Leu Met His Ser Phe Ile His Ala Ala Met Gly Met Val Met 
        115                 120                 125             


Ala Trp Cys Ala Ala Val Ile Thr Gln Gly Gln Tyr Ser Phe Leu Val 
    130                 135                 140                 


Val Pro Cys Thr Gly Thr Asn Ser Phe Gly Ser Pro Ala Ala Gln Thr 
145                 150                 155                 160 


Cys Leu Asn Glu Tyr His Leu Phe Phe Leu Leu Thr Gly Ala Phe Met 
                165                 170                 175     


Gly Tyr Ser Tyr Ser Leu Leu Tyr Phe Val Asn Asn Met Asn Tyr Leu 
            180                 185                 190         


Pro Phe Pro Ile Ile Gln Gln Tyr Lys Phe Leu Arg Phe Arg Arg Ser 
        195                 200                 205             


Leu Leu Leu Leu Val Lys His Ser Cys Val Glu Ser Leu Phe Leu Val 
    210                 215                 220                 


Arg Asn Phe Cys Ile Leu Tyr Tyr Phe Leu Gly Tyr Ile Pro Lys Ala 
225                 230                 235                 240 


Trp Ile Ser Thr Ala Met Asn Leu His Ile Asp Glu Gln Val His Arg 
                245                 250                 255     


Pro Leu Asp Thr Val Ser Gly Leu Leu Asn Leu Ser Leu Leu Tyr His 
            260                 265                 270         


Val Trp Leu Cys Gly Val Phe Leu Leu Thr Thr Trp Tyr Val Ser Trp 
        275                 280                 285             


Ile Leu Phe Lys Ile Tyr Ala Thr Glu Ala His Val Phe Pro Val Gln 
    290                 295                 300                 


Pro Pro Phe Ala Glu Gly Ser Asp Glu Cys Leu Pro Lys Val Leu Asn 
305                 310                 315                 320 


Ser Asn Pro Pro Pro Ile Ile Lys Tyr Leu Ala Leu Gln Asp Leu Met 
                325                 330                 335     


Leu Leu Ser Gln Tyr Ser Pro Ser Arg Arg Gln Glu Val Phe Ser Leu 
            340                 345                 350         


Ser Gln Pro Gly Gly His Pro His Asn Trp Thr Ala Ile Ser Arg Glu 
        355                 360                 365             


Cys Leu Asn Leu Leu Asn Gly Met Thr Gln Lys Leu Ile Leu Tyr Gln 
    370                 375                 380                 


Glu Ala Ala Ala Thr Asn Gly Arg Val Ser Ser Ser Tyr Pro Val Glu 
385                 390                 395                 400 


Pro Lys Lys Leu Asn Ser Pro Glu Glu Thr Ala Phe Gln Thr Pro Lys 
                405                 410                 415     


Ser Ser Gln Met Pro Arg Pro Ser Val Pro Pro Leu Val Lys Thr Ser 
            420                 425                 430         


Leu Phe Ser Ser Lys Leu Ser Thr Pro Asp Val Val Ser Pro Phe Gly 
        435                 440                 445             


Thr Pro Phe Gly Ser Ser Val Met Asn Arg Met Ala Gly Ile Phe Asp 
    450                 455                 460                 


Val Asn Thr Cys Tyr Gly Ser Pro Gln Ser Pro Gln Leu Ile Arg Arg 
465                 470                 475                 480 


Gly Pro Arg Leu Trp Thr Ser Ala Ser Asp Gln Gln Met Thr Glu Phe 
                485                 490                 495     


Ser Asn Pro Ser Pro Ser Thr Ser Ile Ser Ala Glu Gly Lys Thr Met 
            500                 505                 510         


Arg Gln Pro Ser Val Ile Tyr Ser Trp Ile Gln Asn Lys Arg Glu Gln 
        515                 520                 525             


Ile Lys Asn Phe Leu Ser Lys Arg Val Leu Ile Met Tyr Phe Phe Ser 
    530                 535                 540                 


Lys His Pro Glu Ala Ser Ile Gln Ala Val Phe Ser Asp Ala Gln Met 
545                 550                 555                 560 


His Ile Trp Ala Leu Glu Gly Leu Ser His Leu Val Ala Ala Ser Phe 
                565                 570                 575     


Thr Glu Asp Arg Phe Gly Val Val Gln Thr Thr Leu Pro Ala Ile Leu 
            580                 585                 590         


Asn Thr Leu Leu Thr Leu Gln Glu Ala Val Asp Lys Tyr Phe Lys Leu 
        595                 600                 605             


Pro His Ala Ser Ser Lys Pro Pro Arg Ile Ser Gly Ser Leu Val Asp 
    610                 615                 620                 


Thr Ser Tyr Lys Thr Leu Arg Phe Ala Phe Arg Ala Ser Leu Lys Thr 
625                 630                 635                 640 


Ala Ile Tyr Arg Ile Thr Thr Thr Phe Gly Glu His Leu Asn Ala Val 
                645                 650                 655     


Gln Ala Ser Ala Glu His Gln Lys Arg Leu Gln Gln Phe Leu Glu Phe 
            660                 665                 670         


Lys Glu 
        


<210>  161
<211>  1156
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Phe Pro Ala Ala Pro Ser Pro Arg Thr Pro Gly Thr Gly Ser Arg 
1               5                   10                  15      


Arg Gly Pro Leu Ala Gly Leu Gly Pro Gly Ser Thr Pro Arg Thr Ala 
            20                  25                  30          


Ser Arg Lys Gly Leu Pro Leu Gly Ser Ala Val Ser Ser Pro Val Leu 
        35                  40                  45              


Phe Ser Pro Val Gly Arg Arg Ser Ser Leu Ser Ser Arg Gly Thr Pro 
    50                  55                  60                  


Thr Arg Met Phe Pro His His Ser Ile Thr Glu Ser Val Asn Tyr Asp 
65                  70                  75                  80  


Val Lys Thr Phe Gly Ser Ser Leu Pro Val Lys Val Met Glu Ala Leu 
                85                  90                  95      


Thr Leu Ala Glu Val Asp Asp Gln Leu Thr Ile Asn Ile Asp Glu Gly 
            100                 105                 110         


Gly Trp Ala Cys Leu Val Cys Lys Glu Lys Leu Ile Ile Trp Lys Ile 
        115                 120                 125             


Ala Leu Ser Pro Ile Thr Lys Leu Ser Val Cys Lys Glu Leu Gln Leu 
    130                 135                 140                 


Pro Pro Ser Asp Phe His Trp Ser Ala Asp Leu Val Ala Leu Ser Tyr 
145                 150                 155                 160 


Ser Ser Pro Ser Gly Glu Ala His Ser Thr Gln Ala Val Ala Val Met 
                165                 170                 175     


Val Ala Thr Arg Glu Gly Ser Ile Arg Tyr Trp Pro Ser Leu Ala Gly 
            180                 185                 190         


Glu Asp Thr Tyr Thr Glu Ala Phe Val Asp Ser Gly Gly Asp Lys Thr 
        195                 200                 205             


Tyr Ser Phe Leu Thr Ala Val Gln Gly Gly Ser Phe Ile Leu Ser Ser 
    210                 215                 220                 


Ser Gly Ser Gln Leu Ile Arg Leu Ile Pro Glu Ser Ser Gly Lys Ile 
225                 230                 235                 240 


His Gln His Ile Leu Pro Gln Gly Gln Gly Met Leu Ser Gly Ile Gly 
                245                 250                 255     


Arg Lys Val Ser Ser Leu Phe Gly Ile Leu Ser Pro Ser Ser Asp Leu 
            260                 265                 270         


Thr Leu Ser Ser Val Leu Trp Asp Arg Glu Arg Ser Ser Phe Tyr Ser 
        275                 280                 285             


Leu Thr Ser Ser Asn Ile Ser Lys Trp Glu Leu Asp Asp Ser Ser Glu 
    290                 295                 300                 


Lys His Ala Tyr Ser Trp Asp Ile Asn Arg Ala Leu Lys Glu Asn Ile 
305                 310                 315                 320 


Thr Asp Ala Ile Trp Gly Ser Glu Ser Asn Tyr Glu Ala Ile Lys Glu 
                325                 330                 335     


Gly Val Asn Ile Arg Tyr Leu Asp Leu Lys Gln Asn Cys Asp Gly Leu 
            340                 345                 350         


Val Ile Leu Ala Ala Ala Trp His Ser Ala Asp Asn Pro Cys Leu Ile 
        355                 360                 365             


Tyr Tyr Ser Leu Ile Thr Ile Glu Asp Asn Gly Cys Gln Met Ser Asp 
    370                 375                 380                 


Ala Val Thr Val Glu Val Thr Gln Tyr Asn Pro Pro Phe Gln Ser Glu 
385                 390                 395                 400 


Asp Leu Ile Leu Cys Gln Leu Thr Val Pro Asn Phe Ser Asn Gln Thr 
                405                 410                 415     


Ala Tyr Leu Tyr Asn Glu Ser Ala Val Tyr Val Cys Ser Thr Gly Thr 
            420                 425                 430         


Gly Lys Phe Ser Leu Pro Gln Glu Lys Ile Val Phe Asn Ala Gln Gly 
        435                 440                 445             


Asp Ser Val Leu Gly Ala Gly Ala Cys Gly Gly Val Pro Ile Ile Phe 
    450                 455                 460                 


Ser Arg Asn Ser Gly Leu Val Ser Ile Thr Ser Arg Glu Asn Val Ser 
465                 470                 475                 480 


Ile Leu Ala Glu Asp Leu Glu Gly Ser Leu Ala Ser Ser Val Ala Gly 
                485                 490                 495     


Pro Asn Ser Glu Ser Met Ile Phe Glu Thr Thr Thr Lys Asn Glu Thr 
            500                 505                 510         


Ile Ala Gln Glu Asp Lys Ile Lys Leu Leu Lys Ala Ala Phe Leu Gln 
        515                 520                 525             


Tyr Cys Arg Lys Asp Leu Gly His Ala Gln Met Val Val Asp Glu Leu 
    530                 535                 540                 


Phe Ser Ser His Ser Asp Leu Asp Ser Asp Ser Glu Leu Asp Arg Ala 
545                 550                 555                 560 


Val Thr Gln Ile Ser Val Asp Leu Met Asp Asp Tyr Pro Ala Ser Asp 
                565                 570                 575     


Pro Arg Trp Ala Glu Ser Val Pro Glu Glu Ala Pro Gly Phe Ser Asn 
            580                 585                 590         


Thr Ser Leu Ile Ile Leu His Gln Leu Glu Asp Lys Met Lys Ala His 
        595                 600                 605             


Ser Phe Leu Met Asp Phe Ile His Gln Val Gly Leu Phe Gly Arg Leu 
    610                 615                 620                 


Gly Ser Phe Pro Val Arg Gly Thr Pro Met Ala Thr Arg Leu Leu Leu 
625                 630                 635                 640 


Cys Glu His Ala Glu Lys Leu Ser Ala Ala Ile Val Leu Lys Asn His 
                645                 650                 655     


His Ser Arg Leu Ser Asp Leu Val Asn Thr Ala Ile Leu Ile Ala Leu 
            660                 665                 670         


Asn Lys Arg Glu Tyr Glu Ile Pro Ser Asn Leu Thr Pro Ala Asp Val 
        675                 680                 685             


Phe Phe Arg Glu Val Ser Gln Val Asp Thr Ile Cys Glu Cys Leu Leu 
    690                 695                 700                 


Glu His Glu Glu Gln Val Leu Arg Asp Ala Pro Met Asp Ser Ile Glu 
705                 710                 715                 720 


Trp Ala Glu Val Val Ile Asn Val Asn Asn Ile Leu Lys Asp Met Leu 
                725                 730                 735     


Gln Ala Ala Ser His Tyr Arg Gln Asn Arg Asn Ser Leu Tyr Arg Arg 
            740                 745                 750         


Glu Glu Ser Leu Glu Lys Glu Pro Glu Tyr Val Pro Trp Thr Ala Thr 
        755                 760                 765             


Ser Gly Pro Gly Gly Ile Arg Thr Val Ile Ile Arg Gln His Glu Ile 
    770                 775                 780                 


Val Leu Lys Val Ala Tyr Pro Gln Ala Asp Ser Asn Leu Arg Asn Ile 
785                 790                 795                 800 


Val Thr Glu Gln Leu Val Ala Leu Ile Asp Cys Phe Leu Asp Gly Tyr 
                805                 810                 815     


Val Ser Gln Leu Lys Ser Val Asp Lys Ser Ser Asn Arg Glu Arg Tyr 
            820                 825                 830         


Asp Asn Leu Glu Met Glu Tyr Leu Gln Lys Arg Ser Asp Leu Leu Ser 
        835                 840                 845             


Pro Leu Leu Ser Leu Gly Gln Tyr Leu Trp Ala Ala Ser Leu Ala Glu 
    850                 855                 860                 


Lys Tyr Cys Asp Phe Asp Ile Leu Val Gln Met Cys Glu Gln Thr Asp 
865                 870                 875                 880 


Asn Gln Ser Arg Leu Gln Arg Tyr Met Thr Gln Phe Ala Asp Gln Asn 
                885                 890                 895     


Phe Ser Asp Phe Leu Phe Arg Trp Tyr Leu Glu Lys Gly Lys Arg Gly 
            900                 905                 910         


Lys Leu Leu Ser Gln Pro Ile Ser Gln His Gly Gln Leu Ala Asn Phe 
        915                 920                 925             


Leu Gln Ala His Glu His Leu Ser Trp Leu His Glu Ile Asn Ser Gln 
    930                 935                 940                 


Glu Leu Glu Lys Ala His Ala Thr Leu Leu Gly Leu Ala Asn Met Glu 
945                 950                 955                 960 


Thr Arg Tyr Phe Ala Lys Lys Lys Thr Leu Leu Gly Leu Ser Lys Leu 
                965                 970                 975     


Ala Ala Leu Ala Ser Asp Phe Ser Glu Asp Met Leu Gln Glu Lys Ile 
            980                 985                 990         


Glu Glu Met Ala Glu Gln Glu Arg  Phe Leu Leu His Gln  Glu Thr Leu 
        995                 1000                 1005             


Pro Glu  Gln Leu Leu Ala Glu  Lys Gln Leu Asn Leu  Ser Ala Met 
    1010                 1015                 1020             


Pro Val  Leu Thr Ala Pro Gln  Leu Ile Gly Leu Tyr  Ile Cys Glu 
    1025                 1030                 1035             


Glu Asn  Arg Arg Ala Asn Glu  Tyr Asp Phe Lys Lys  Ala Leu Asp 
    1040                 1045                 1050             


Leu Leu  Glu Tyr Ile Asp Glu  Glu Glu Asp Ile Asn  Ile Asn Asp 
    1055                 1060                 1065             


Leu Lys  Leu Glu Ile Leu Cys  Lys Ala Leu Gln Arg  Asp Asn Trp 
    1070                 1075                 1080             


Ser Ser  Ser Asp Gly Lys Asp  Asp Pro Ile Glu Val  Ser Lys Asp 
    1085                 1090                 1095             


Ser Ile  Phe Val Lys Ile Leu  Gln Lys Leu Leu Lys  Asp Gly Ile 
    1100                 1105                 1110             


Gln Leu  Ser Glu Tyr Leu Pro  Glu Val Lys Asp Leu  Leu Gln Ala 
    1115                 1120                 1125             


Asp Gln  Leu Gly Ser Leu Lys  Ser Asn Pro Tyr Phe  Glu Phe Val 
    1130                 1135                 1140             


Leu Lys  Ala Asn Tyr Glu Tyr  Tyr Val Gln Gly Gln  Ile 
    1145                 1150                 1155     


<210>  162
<211>  1220
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Gly Lys Lys Gln Lys Asn Lys Ser Glu Asp Ser Thr Lys Asp Asp 
1               5                   10                  15      


Ile Asp Leu Asp Ala Leu Ala Ala Glu Ile Glu Gly Ala Gly Ala Ala 
            20                  25                  30          


Lys Glu Gln Glu Pro Gln Lys Ser Lys Gly Lys Lys Lys Lys Glu Lys 
        35                  40                  45              


Lys Lys Gln Asp Phe Asp Glu Asp Asp Ile Leu Lys Glu Leu Glu Glu 
    50                  55                  60                  


Leu Ser Leu Glu Ala Gln Gly Ile Lys Ala Asp Arg Glu Thr Val Ala 
65                  70                  75                  80  


Val Lys Pro Thr Glu Asn Asn Glu Glu Glu Phe Thr Ser Lys Asp Lys 
                85                  90                  95      


Lys Lys Lys Gly Gln Lys Gly Lys Lys Gln Ser Phe Asp Asp Asn Asp 
            100                 105                 110         


Ser Glu Glu Leu Glu Asp Lys Asp Ser Lys Ser Lys Lys Thr Ala Lys 
        115                 120                 125             


Pro Lys Val Glu Met Tyr Ser Gly Ser Asp Asp Asp Asp Asp Phe Asn 
    130                 135                 140                 


Lys Leu Pro Lys Lys Ala Lys Gly Lys Ala Gln Lys Ser Asn Lys Lys 
145                 150                 155                 160 


Trp Asp Gly Ser Glu Glu Asp Glu Asp Asn Ser Lys Lys Ile Lys Glu 
                165                 170                 175     


Arg Ser Arg Ile Asn Ser Ser Gly Glu Ser Gly Asp Glu Ser Asp Glu 
            180                 185                 190         


Phe Leu Gln Ser Arg Lys Gly Gln Lys Lys Asn Gln Lys Asn Lys Pro 
        195                 200                 205             


Gly Pro Asn Ile Glu Ser Gly Asn Glu Asp Asp Asp Ala Ser Phe Lys 
    210                 215                 220                 


Ile Lys Thr Val Ala Gln Lys Lys Ala Glu Lys Lys Glu Arg Glu Arg 
225                 230                 235                 240 


Lys Lys Arg Asp Glu Glu Lys Ala Lys Leu Arg Lys Leu Lys Glu Lys 
                245                 250                 255     


Glu Glu Leu Glu Thr Gly Lys Lys Asp Gln Ser Lys Gln Lys Glu Ser 
            260                 265                 270         


Gln Arg Lys Phe Glu Glu Glu Thr Val Lys Ser Lys Val Thr Val Asp 
        275                 280                 285             


Thr Gly Val Ile Pro Ala Ser Glu Glu Lys Ala Glu Thr Pro Thr Ala 
    290                 295                 300                 


Ala Glu Asp Asp Asn Glu Gly Asp Lys Lys Lys Lys Asp Lys Lys Lys 
305                 310                 315                 320 


Lys Lys Gly Glu Lys Glu Glu Lys Glu Lys Glu Lys Lys Lys Gly Pro 
                325                 330                 335     


Ser Lys Ala Thr Val Lys Ala Met Gln Glu Ala Leu Ala Lys Leu Lys 
            340                 345                 350         


Glu Glu Glu Glu Arg Gln Lys Arg Glu Glu Glu Glu Arg Ile Lys Arg 
        355                 360                 365             


Leu Glu Glu Leu Glu Ala Lys Arg Lys Glu Glu Glu Arg Leu Glu Gln 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Lys Gln Lys Glu Lys Glu Arg Lys Glu Arg 
385                 390                 395                 400 


Leu Lys Lys Glu Gly Lys Leu Leu Thr Lys Ser Gln Arg Glu Ala Arg 
                405                 410                 415     


Ala Arg Ala Glu Ala Thr Leu Lys Leu Leu Gln Ala Gln Gly Val Glu 
            420                 425                 430         


Val Pro Ser Lys Asp Ser Leu Pro Lys Lys Arg Pro Ile Tyr Glu Asp 
        435                 440                 445             


Lys Lys Arg Lys Lys Ile Pro Gln Gln Leu Glu Ser Lys Glu Val Ser 
    450                 455                 460                 


Glu Ser Met Glu Leu Cys Ala Ala Val Glu Val Met Glu Gln Gly Val 
465                 470                 475                 480 


Pro Glu Lys Glu Glu Thr Pro Pro Pro Val Glu Pro Glu Glu Glu Glu 
                485                 490                 495     


Asp Thr Glu Asp Ala Gly Leu Asp Asp Trp Glu Ala Met Ala Ser Asp 
            500                 505                 510         


Glu Glu Thr Glu Lys Val Glu Gly Asn Lys Val His Ile Glu Val Lys 
        515                 520                 525             


Glu Asn Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp 
    530                 535                 540                 


Glu Glu Ser Glu Glu Glu Glu Glu Glu Glu Gly Glu Ser Glu Gly Ser 
545                 550                 555                 560 


Glu Gly Asp Glu Glu Asp Glu Lys Val Ser Asp Glu Lys Asp Ser Gly 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Pro Ser Lys Glu Met Ser Ser Asp Ser Glu 
            580                 585                 590         


Tyr Asp Ser Asp Asp Asp Arg Thr Lys Glu Glu Arg Ala Tyr Asp Lys 
        595                 600                 605             


Ala Lys Arg Arg Ile Glu Lys Arg Arg Leu Glu His Ser Lys Asn Val 
    610                 615                 620                 


Asn Thr Glu Lys Leu Arg Ala Pro Ile Ile Cys Val Leu Gly His Val 
625                 630                 635                 640 


Asp Thr Gly Lys Thr Lys Ile Leu Asp Lys Leu Arg His Thr His Val 
                645                 650                 655     


Gln Asp Gly Glu Ala Gly Gly Ile Thr Gln Gln Ile Gly Ala Thr Asn 
            660                 665                 670         


Val Pro Leu Glu Ala Ile Asn Glu Gln Thr Lys Met Ile Lys Asn Phe 
        675                 680                 685             


Asp Arg Glu Asn Val Arg Ile Pro Gly Met Leu Ile Ile Asp Thr Pro 
    690                 695                 700                 


Gly His Glu Ser Phe Ser Asn Leu Arg Asn Arg Gly Ser Ser Leu Cys 
705                 710                 715                 720 


Asp Ile Ala Ile Leu Val Val Asp Ile Met His Gly Leu Glu Pro Gln 
                725                 730                 735     


Thr Ile Glu Ser Ile Asn Leu Leu Lys Ser Lys Lys Cys Pro Phe Ile 
            740                 745                 750         


Val Ala Leu Asn Lys Ile Asp Arg Leu Tyr Asp Trp Lys Lys Ser Pro 
        755                 760                 765             


Asp Ser Asp Val Ala Ala Thr Leu Lys Lys Gln Lys Lys Asn Thr Lys 
    770                 775                 780                 


Asp Glu Phe Glu Glu Arg Ala Lys Ala Ile Ile Val Glu Phe Ala Gln 
785                 790                 795                 800 


Gln Gly Leu Asn Ala Ala Leu Phe Tyr Glu Asn Lys Asp Pro Arg Thr 
                805                 810                 815     


Phe Val Ser Leu Val Pro Thr Ser Ala His Thr Gly Asp Gly Met Gly 
            820                 825                 830         


Ser Leu Ile Tyr Leu Leu Val Glu Leu Thr Gln Thr Met Leu Ser Lys 
        835                 840                 845             


Arg Leu Ala His Cys Glu Glu Leu Arg Ala Gln Val Met Glu Val Lys 
    850                 855                 860                 


Ala Leu Pro Gly Met Gly Thr Thr Ile Asp Val Ile Leu Ile Asn Gly 
865                 870                 875                 880 


Arg Leu Lys Glu Gly Asp Thr Ile Ile Val Pro Gly Val Glu Gly Pro 
                885                 890                 895     


Ile Val Thr Gln Ile Arg Gly Leu Leu Leu Pro Pro Pro Met Lys Glu 
            900                 905                 910         


Leu Arg Val Lys Asn Gln Tyr Glu Lys His Lys Glu Val Glu Ala Ala 
        915                 920                 925             


Gln Gly Val Lys Ile Leu Gly Lys Asp Leu Glu Lys Thr Leu Ala Gly 
    930                 935                 940                 


Leu Pro Leu Leu Val Ala Tyr Lys Glu Asp Glu Ile Pro Val Leu Lys 
945                 950                 955                 960 


Asp Glu Leu Ile His Glu Leu Lys Gln Thr Leu Asn Ala Ile Lys Leu 
                965                 970                 975     


Glu Glu Lys Gly Val Tyr Val Gln Ala Ser Thr Leu Gly Ser Leu Glu 
            980                 985                 990         


Ala Leu Leu Glu Phe Leu Lys Thr  Ser Glu Val Pro Tyr  Ala Gly Ile 
        995                 1000                 1005             


Asn Ile  Gly Pro Val His Lys  Lys Asp Val Met Lys  Ala Ser Val 
    1010                 1015                 1020             


Met Leu  Glu His Asp Pro Gln  Tyr Ala Val Ile Leu  Ala Phe Asp 
    1025                 1030                 1035             


Val Arg  Ile Glu Arg Asp Ala  Gln Glu Met Ala Asp  Ser Leu Gly 
    1040                 1045                 1050             


Val Arg  Ile Phe Ser Ala Glu  Ile Ile Tyr His Leu  Phe Asp Ala 
    1055                 1060                 1065             


Phe Thr  Lys Tyr Arg Gln Asp  Tyr Lys Lys Gln Lys  Gln Glu Glu 
    1070                 1075                 1080             


Phe Lys  His Ile Ala Val Phe  Pro Cys Lys Ile Lys  Ile Leu Pro 
    1085                 1090                 1095             


Gln Tyr  Ile Phe Asn Ser Arg  Asp Pro Ile Val Met  Gly Val Thr 
    1100                 1105                 1110             


Val Glu  Ala Gly Gln Val Lys  Gln Gly Thr Pro Met  Cys Val Pro 
    1115                 1120                 1125             


Ser Lys  Asn Phe Val Asp Ile  Gly Ile Val Thr Ser  Ile Glu Ile 
    1130                 1135                 1140             


Asn His  Lys Gln Val Asp Val  Ala Lys Lys Gly Gln  Glu Val Cys 
    1145                 1150                 1155             


Val Lys  Ile Glu Pro Ile Pro  Gly Glu Ser Pro Lys  Met Phe Gly 
    1160                 1165                 1170             


Arg His  Phe Glu Ala Thr Asp  Ile Leu Val Ser Lys  Ile Ser Arg 
    1175                 1180                 1185             


Gln Ser  Ile Asp Ala Leu Lys  Asp Trp Phe Arg Asp  Glu Met Gln 
    1190                 1195                 1200             


Lys Ser  Asp Trp Gln Leu Ile  Val Glu Leu Lys Lys  Val Phe Glu 
    1205                 1210                 1215             


Ile Ile  
    1220 


<210>  163
<211>  1341
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Trp Arg Arg Lys His Pro Arg Thr Ser Gly Gly Thr Arg Gly Val 
1               5                   10                  15      


Leu Ser Gly Asn Arg Gly Val Glu Tyr Gly Ser Gly Arg Gly His Leu 
            20                  25                  30          


Gly Thr Phe Glu Gly Arg Trp Arg Lys Leu Pro Lys Met Pro Glu Ala 
        35                  40                  45              


Val Gly Thr Asp Pro Ser Thr Ser Arg Lys Met Ala Glu Leu Glu Glu 
    50                  55                  60                  


Val Thr Leu Asp Gly Lys Pro Leu Gln Ala Leu Arg Val Thr Asp Leu 
65                  70                  75                  80  


Lys Ala Ala Leu Glu Gln Arg Gly Leu Ala Lys Ser Gly Gln Lys Ser 
                85                  90                  95      


Ala Leu Val Lys Arg Leu Lys Gly Ala Leu Met Leu Glu Asn Leu Gln 
            100                 105                 110         


Lys His Ser Thr Pro His Ala Ala Phe Gln Pro Asn Ser Gln Ile Gly 
        115                 120                 125             


Glu Glu Met Ser Gln Asn Ser Phe Ile Lys Gln Tyr Leu Glu Lys Gln 
    130                 135                 140                 


Gln Glu Leu Leu Arg Gln Arg Leu Glu Arg Glu Ala Arg Glu Ala Ala 
145                 150                 155                 160 


Glu Leu Glu Glu Ala Ser Ala Glu Ser Glu Asp Glu Met Ile His Pro 
                165                 170                 175     


Glu Gly Val Ala Ser Leu Leu Pro Pro Asp Phe Gln Ser Ser Leu Glu 
            180                 185                 190         


Arg Pro Glu Leu Glu Leu Ser Arg His Ser Pro Arg Lys Ser Ser Ser 
        195                 200                 205             


Ile Ser Glu Glu Lys Gly Asp Ser Asp Asp Glu Lys Pro Arg Lys Gly 
    210                 215                 220                 


Glu Arg Arg Ser Ser Arg Val Arg Gln Ala Arg Ala Ala Lys Leu Ser 
225                 230                 235                 240 


Glu Gly Ser Gln Pro Ala Glu Glu Glu Glu Asp Gln Glu Thr Pro Ser 
                245                 250                 255     


Arg Asn Leu Arg Val Arg Ala Asp Arg Asn Leu Lys Thr Glu Glu Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Gly 
        275                 280                 285             


Asp Asp Glu Gly Gln Lys Ser Arg Glu Ala Pro Ile Leu Lys Glu Phe 
    290                 295                 300                 


Lys Glu Glu Gly Glu Glu Ile Pro Arg Val Lys Pro Glu Glu Met Met 
305                 310                 315                 320 


Asp Glu Arg Pro Lys Thr Arg Ser Gln Glu Gln Glu Val Leu Glu Arg 
                325                 330                 335     


Gly Gly Arg Phe Thr Arg Ser Gln Glu Glu Ala Arg Lys Ser His Leu 
            340                 345                 350         


Ala Arg Gln Gln Gln Glu Lys Glu Met Lys Thr Thr Ser Pro Leu Glu 
        355                 360                 365             


Glu Glu Glu Arg Glu Ile Lys Ser Ser Gln Gly Leu Lys Glu Lys Ser 
    370                 375                 380                 


Lys Ser Pro Ser Pro Pro Arg Leu Thr Glu Asp Arg Lys Lys Ala Ser 
385                 390                 395                 400 


Leu Val Ala Leu Pro Glu Gln Thr Ala Ser Glu Glu Glu Thr Pro Pro 
                405                 410                 415     


Pro Leu Leu Thr Lys Glu Ala Ser Ser Pro Pro Pro His Pro Gln Leu 
            420                 425                 430         


His Ser Glu Glu Glu Ile Glu Pro Met Glu Gly Pro Ala Pro Ala Val 
        435                 440                 445             


Leu Ile Gln Leu Ser Pro Pro Asn Thr Asp Ala Asp Thr Arg Glu Leu 
    450                 455                 460                 


Leu Val Ser Gln His Thr Val Gln Leu Val Gly Gly Leu Ser Pro Leu 
465                 470                 475                 480 


Ser Ser Pro Ser Asp Thr Lys Ala Glu Ser Pro Ala Glu Lys Val Pro 
                485                 490                 495     


Glu Glu Ser Val Leu Pro Leu Val Gln Lys Ser Thr Leu Ala Asp Tyr 
            500                 505                 510         


Ser Ala Gln Lys Asp Leu Glu Pro Glu Ser Asp Arg Ser Ala Gln Pro 
        515                 520                 525             


Leu Pro Leu Lys Ile Glu Glu Leu Ala Leu Ala Lys Gly Ile Thr Glu 
    530                 535                 540                 


Glu Cys Leu Lys Gln Pro Ser Leu Glu Gln Lys Glu Gly Arg Arg Ala 
545                 550                 555                 560 


Ser His Thr Leu Leu Pro Ser His Arg Leu Lys Gln Ser Ala Asp Ser 
                565                 570                 575     


Ser Ser Ser Arg Ser Ser Ser Ser Ser Ser Ser Ser Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Asp Ser Ser Gly Ser Arg Ser His Ser Pro Leu Arg 
        595                 600                 605             


Ser Lys Gln Arg Asp Val Ala Gln Ala Arg Thr His Ala Asn Pro Arg 
    610                 615                 620                 


Gly Arg Pro Lys Met Gly Ser Arg Ser Thr Ser Glu Ser Arg Ser Arg 
625                 630                 635                 640 


Ser Arg Ser Arg Ser Arg Ser Ala Ser Ser Asn Ser Arg Lys Ser Leu 
                645                 650                 655     


Ser Pro Gly Val Ser Arg Asp Ser Ser Thr Ser Tyr Thr Glu Thr Lys 
            660                 665                 670         


Asp Pro Ser Ser Gly Gln Glu Val Ala Thr Pro Pro Val Pro Gln Leu 
        675                 680                 685             


Gln Val Cys Glu Pro Lys Glu Arg Thr Ser Thr Ser Ser Ser Ser Val 
    690                 695                 700                 


Gln Ala Arg Arg Leu Ser Gln Pro Glu Ser Ala Glu Lys His Val Thr 
705                 710                 715                 720 


Gln Arg Leu Gln Pro Glu Arg Gly Ser Pro Lys Lys Cys Glu Ala Glu 
                725                 730                 735     


Glu Ala Glu Pro Pro Ala Ala Thr Gln Pro Gln Thr Ser Glu Thr Gln 
            740                 745                 750         


Thr Ser His Leu Pro Glu Ser Glu Arg Ile His His Thr Val Glu Glu 
        755                 760                 765             


Lys Glu Glu Val Thr Met Asp Thr Ser Glu Asn Arg Pro Glu Asn Asp 
    770                 775                 780                 


Val Pro Glu Pro Pro Met Pro Ile Ala Asp Gln Val Ser Asn Asp Asp 
785                 790                 795                 800 


Arg Pro Glu Gly Ser Val Glu Asp Glu Glu Lys Lys Glu Ser Ser Leu 
                805                 810                 815     


Pro Lys Ser Phe Lys Arg Lys Ile Ser Val Val Ser Ala Thr Lys Gly 
            820                 825                 830         


Val Pro Ala Gly Asn Ser Asp Thr Glu Gly Gly Gln Pro Gly Arg Lys 
        835                 840                 845             


Arg Arg Trp Gly Ala Ser Thr Ala Thr Thr Gln Lys Lys Pro Ser Ile 
    850                 855                 860                 


Ser Ile Thr Thr Glu Ser Leu Lys Ser Leu Ile Pro Asp Ile Lys Pro 
865                 870                 875                 880 


Leu Ala Gly Gln Glu Ala Val Val Asp Leu His Ala Asp Asp Ser Arg 
                885                 890                 895     


Ile Ser Glu Asp Glu Thr Glu Arg Asn Gly Asp Asp Gly Thr His Asp 
            900                 905                 910         


Lys Gly Leu Lys Ile Cys Arg Thr Val Thr Gln Val Val Pro Ala Glu 
        915                 920                 925             


Gly Gln Glu Asn Gly Gln Arg Glu Glu Glu Glu Glu Glu Lys Glu Pro 
    930                 935                 940                 


Glu Ala Glu Pro Pro Val Pro Pro Gln Val Ser Val Glu Val Ala Leu 
945                 950                 955                 960 


Pro Pro Pro Ala Glu His Glu Val Lys Lys Val Thr Leu Gly Asp Thr 
                965                 970                 975     


Leu Thr Arg Arg Ser Ile Ser Gln Gln Lys Ser Gly Val Ser Ile Thr 
            980                 985                 990         


Ile Asp Asp Pro Val Arg Thr Ala  Gln Val Pro Ser Pro  Pro Arg Gly 
        995                 1000                 1005             


Lys Ile  Ser Asn Ile Val His  Ile Ser Asn Leu Val  Arg Pro Phe 
    1010                 1015                 1020             


Thr Leu  Gly Gln Leu Lys Glu  Leu Leu Gly Arg Thr  Gly Thr Leu 
    1025                 1030                 1035             


Val Glu  Glu Ala Phe Trp Ile  Asp Lys Ile Lys Ser  His Cys Phe 
    1040                 1045                 1050             


Val Thr  Tyr Ser Thr Val Glu  Glu Ala Val Ala Thr  Arg Thr Ala 
    1055                 1060                 1065             


Leu His  Gly Val Lys Trp Pro  Gln Ser Asn Pro Lys  Phe Leu Cys 
    1070                 1075                 1080             


Ala Asp  Tyr Ala Glu Gln Asp  Glu Leu Asp Tyr His  Arg Gly Leu 
    1085                 1090                 1095             


Leu Val  Asp Arg Pro Ser Glu  Thr Lys Thr Glu Glu  Gln Gly Ile 
    1100                 1105                 1110             


Pro Arg  Pro Leu His Pro Pro  Pro Pro Pro Pro Val  Gln Pro Pro 
    1115                 1120                 1125             


Gln His  Pro Arg Ala Glu Gln  Arg Glu Gln Glu Arg  Ala Val Arg 
    1130                 1135                 1140             


Glu Gln  Trp Ala Glu Arg Glu  Arg Glu Met Glu Arg  Arg Glu Arg 
    1145                 1150                 1155             


Thr Arg  Ser Glu Arg Glu Trp  Asp Arg Asp Lys Val  Arg Glu Gly 
    1160                 1165                 1170             


Pro Arg  Ser Arg Ser Arg Ser  Arg Asp Arg Arg Arg  Lys Glu Arg 
    1175                 1180                 1185             


Ala Lys  Ser Lys Glu Lys Lys  Ser Glu Lys Lys Glu  Lys Ala Gln 
    1190                 1195                 1200             


Glu Glu  Pro Pro Ala Lys Leu  Leu Asp Asp Leu Phe  Arg Lys Thr 
    1205                 1210                 1215             


Lys Ala  Ala Pro Cys Ile Tyr  Trp Leu Pro Leu Thr  Asp Ser Gln 
    1220                 1225                 1230             


Ile Val  Gln Lys Glu Ala Glu  Arg Ala Glu Arg Ala  Lys Glu Arg 
    1235                 1240                 1245             


Glu Lys  Arg Arg Lys Glu Gln  Glu Glu Glu Glu Gln  Lys Glu Arg 
    1250                 1255                 1260             


Glu Lys  Glu Ala Glu Arg Glu  Arg Asn Arg Gln Leu  Glu Arg Glu 
    1265                 1270                 1275             


Lys Arg  Arg Glu His Ser Arg  Glu Arg Asp Arg Glu  Arg Glu Arg 
    1280                 1285                 1290             


Glu Arg  Glu Arg Asp Arg Gly  Asp Arg Asp Arg Asp  Arg Glu Arg 
    1295                 1300                 1305             


Asp Arg  Glu Arg Gly Arg Glu  Arg Asp Arg Arg Asp  Thr Lys Arg 
    1310                 1315                 1320             


His Ser  Arg Ser Arg Ser Arg  Ser Thr Pro Val Arg  Asp Arg Gly 
    1325                 1330                 1335             


Gly Arg  Arg 
    1340     


<210>  164
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ala Asp Lys Met Asp Met Ser Leu Asp Asp Ile Ile Lys Leu Asn 
1               5                   10                  15      


Arg Ser Gln Arg Gly Gly Arg Gly Gly Gly Arg Gly Arg Gly Arg Ala 
            20                  25                  30          


Gly Ser Gln Gly Gly Arg Gly Gly Gly Ala Gln Ala Ala Ala Arg Val 
        35                  40                  45              


Asn Arg Gly Gly Gly Pro Ile Arg Asn Arg Pro Ala Ile Ala Arg Gly 
    50                  55                  60                  


Ala Ala Gly Gly Gly Gly Arg Asn Arg Pro Ala Pro Tyr Ser Arg Pro 
65                  70                  75                  80  


Lys Gln Leu Pro Asp Lys Trp Gln His Asp Leu Phe Asp Ser Gly Phe 
                85                  90                  95      


Gly Gly Gly Ala Gly Val Glu Thr Gly Gly Lys Leu Leu Val Ser Asn 
            100                 105                 110         


Leu Asp Phe Gly Val Ser Asp Ala Asp Ile Gln Glu Leu Phe Ala Glu 
        115                 120                 125             


Phe Gly Thr Leu Lys Lys Ala Ala Val His Tyr Asp Arg Ser Gly Arg 
    130                 135                 140                 


Ser Leu Gly Thr Ala Asp Val His Phe Glu Arg Lys Ala Asp Ala Leu 
145                 150                 155                 160 


Lys Ala Met Lys Gln Tyr Asn Gly Val Pro Leu Asp Gly Arg Pro Met 
                165                 170                 175     


Asn Ile Gln Leu Val Thr Ser Gln Ile Asp Ala Gln Arg Arg Pro Ala 
            180                 185                 190         


Gln Ser Val Asn Arg Gly Gly Met Thr Arg Asn Arg Gly Ala Gly Gly 
        195                 200                 205             


Phe Gly Gly Gly Gly Gly Thr Arg Arg Gly Thr Arg Gly Gly Ala Arg 
    210                 215                 220                 


Gly Arg Gly Arg Gly Ala Gly Arg Asn Ser Lys Gln Gln Leu Ser Ala 
225                 230                 235                 240 


Glu Glu Leu Asp Ala Gln Leu Asp Ala Tyr Asn Ala Arg Met Asp Thr 
                245                 250                 255     


Ser 
    


<210>  165
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ala Met Ser Ser Gly Gly Ser Gly Gly Gly Val Pro Glu Gln Glu 
1               5                   10                  15      


Asp Ser Val Leu Phe Arg Arg Gly Thr Gly Gln Ser Asp Asp Ser Asp 
            20                  25                  30          


Ile Trp Asp Asp Thr Ala Leu Ile Lys Ala Tyr Asp Lys Ala Val Ala 
        35                  40                  45              


Ser Phe Lys His Ala Leu Lys Asn Gly Asp Ile Cys Glu Thr Ser Gly 
    50                  55                  60                  


Lys Pro Lys Thr Thr Pro Lys Arg Lys Pro Ala Lys Lys Asn Lys Ser 
65                  70                  75                  80  


Gln Lys Lys Asn Thr Ala Ala Ser Leu Gln Gln Trp Lys Val Gly Asp 
                85                  90                  95      


Lys Cys Ser Ala Ile Trp Ser Glu Asp Gly Cys Ile Tyr Pro Ala Thr 
            100                 105                 110         


Ile Ala Ser Ile Asp Phe Lys Arg Glu Thr Cys Val Val Val Tyr Thr 
        115                 120                 125             


Gly Tyr Gly Asn Arg Glu Glu Gln Asn Leu Ser Asp Leu Leu Ser Pro 
    130                 135                 140                 


Ile Cys Glu Val Ala Asn Asn Ile Glu Gln Asn Ala Gln Glu Asn Glu 
145                 150                 155                 160 


Asn Glu Ser Gln Val Ser Thr Asp Glu Ser Glu Asn Ser Arg Ser Pro 
                165                 170                 175     


Gly Asn Lys Ser Asp Asn Ile Lys Pro Lys Ser Ala Pro Trp Asn Ser 
            180                 185                 190         


Phe Leu Pro Pro Pro Pro Pro Met Pro Gly Pro Arg Leu Gly Pro Gly 
        195                 200                 205             


Lys Pro Gly Leu Lys Phe Asn Gly Pro Pro Pro Pro Pro Pro Pro Pro 
    210                 215                 220                 


Pro Pro His Leu Leu Ser Cys Trp Leu Pro Pro Phe Pro Ser Gly Pro 
225                 230                 235                 240 


Pro Ile Ile Pro Pro Pro Pro Pro Ile Cys Pro Asp Ser Leu Asp Asp 
                245                 250                 255     


Ala Asp Ala Leu Gly Ser Met Leu Ile Ser Trp Tyr Met Ser Gly Tyr 
            260                 265                 270         


His Thr Gly Tyr Tyr Met Gly Phe Arg Gln Asn Gln Lys Glu Gly Arg 
        275                 280                 285             


Cys Ser His Ser Leu Asn 
    290                 


<210>  166
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  167
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Gln Asp Ala Glu Asn Val Ala Val Pro Glu Ala Ala Glu Glu Arg 
1               5                   10                  15      


Ala Glu Pro Gly Gln Gln Gln Pro Ala Ala Glu Pro Pro Pro Ala Glu 
            20                  25                  30          


Gly Leu Leu Arg Pro Ala Gly Pro Gly Ala Pro Glu Ala Ala Gly Thr 
        35                  40                  45              


Glu Ala Ser Ser Glu Glu Val Gly Ile Ala Glu Ala Gly Pro Glu Ser 
    50                  55                  60                  


Glu Val Arg Thr Glu Pro Ala Ala Glu Ala Glu Ala Ala Ser Gly Pro 
65                  70                  75                  80  


Ser Glu Ser Pro Ser Pro Pro Ala Ala Glu Glu Leu Pro Gly Ser His 
                85                  90                  95      


Ala Glu Pro Pro Val Pro Ala Gln Gly Glu Ala Pro Gly Glu Gln Ala 
            100                 105                 110         


Arg Asp Glu Arg Ser Asp Ser Arg Ala Gln Ala Val Ser Glu Asp Ala 
        115                 120                 125             


Gly Gly Asn Glu Gly Arg Ala Ala Glu Ala Glu Pro Arg Ala Leu Glu 
    130                 135                 140                 


Asn Gly Asp Ala Asp Glu Pro Ser Phe Ser Asp Pro Glu Asp Phe Val 
145                 150                 155                 160 


Asp Asp Val Ser Glu Glu Glu Leu Leu Gly Asp Val Leu Lys Asp Arg 
                165                 170                 175     


Pro Gln Glu Ala Asp Gly Ile Asp Ser Val Ile Val Val Asp Asn Val 
            180                 185                 190         


Pro Gln Val Gly Pro Asp Arg Leu Glu Lys Leu Lys Asn Val Ile His 
        195                 200                 205             


Lys Ile Phe Ser Lys Phe Gly Lys Ile Thr Asn Asp Phe Tyr Pro Glu 
    210                 215                 220                 


Glu Asp Gly Lys Thr Lys Gly Tyr Ile Phe Leu Glu Tyr Ala Ser Pro 
225                 230                 235                 240 


Ala His Ala Val Asp Ala Val Lys Asn Ala Asp Gly Tyr Lys Leu Asp 
                245                 250                 255     


Lys Gln His Thr Phe Arg Val Asn Leu Phe Thr Asp Phe Asp Lys Tyr 
            260                 265                 270         


Met Thr Ile Ser Asp Glu Trp Asp Ile Pro Glu Lys Gln Pro Phe Lys 
        275                 280                 285             


Asp Leu Gly Asn Leu Arg Tyr Trp Leu Glu Glu Ala Glu Cys Arg Asp 
    290                 295                 300                 


Gln Tyr Ser Val Ile Phe Glu Ser Gly Asp Arg Thr Ser Ile Phe Trp 
305                 310                 315                 320 


Asn Asp Val Lys Asp Pro Val Ser Ile Glu Glu Arg Ala Arg Trp Thr 
                325                 330                 335     


Glu Thr Tyr Val Arg Trp Ser Pro Lys Gly Thr Tyr Leu Ala Thr Phe 
            340                 345                 350         


His Gln Arg Gly Ile Ala Leu Trp Gly Gly Glu Lys Phe Lys Gln Ile 
        355                 360                 365             


Gln Arg Phe Ser His Gln Gly Val Gln Leu Ile Asp Phe Ser Pro Cys 
    370                 375                 380                 


Glu Arg Tyr Leu Val Thr Phe Ser Pro Leu Met Asp Thr Gln Asp Asp 
385                 390                 395                 400 


Pro Gln Ala Ile Ile Ile Trp Asp Ile Leu Thr Gly His Lys Lys Arg 
                405                 410                 415     


Gly Phe His Cys Glu Ser Ser Ala His Trp Pro Ile Phe Lys Trp Ser 
            420                 425                 430         


His Asp Gly Lys Phe Phe Ala Arg Met Thr Leu Asp Thr Leu Ser Ile 
        435                 440                 445             


Tyr Glu Thr Pro Ser Met Gly Leu Leu Asp Lys Lys Ser Leu Lys Ile 
    450                 455                 460                 


Ser Gly Ile Lys Asp Phe Ser Trp Ser Pro Gly Gly Asn Ile Ile Ala 
465                 470                 475                 480 


Phe Trp Val Pro Glu Asp Lys Asp Ile Pro Ala Arg Val Thr Leu Met 
                485                 490                 495     


Gln Leu Pro Thr Arg Gln Glu Ile Arg Val Arg Asn Leu Phe Asn Val 
            500                 505                 510         


Val Asp Cys Lys Leu His Trp Gln Lys Asn Gly Asp Tyr Leu Cys Val 
        515                 520                 525             


Lys Val Asp Arg Thr Pro Lys Gly Thr Gln Gly Val Val Thr Asn Phe 
    530                 535                 540                 


Glu Ile Phe Arg Met Arg Glu Lys Gln Val Pro Val Asp Val Val Glu 
545                 550                 555                 560 


Met Lys Glu Thr Ile Ile Ala Phe Ala Trp Glu Pro Asn Gly Ser Lys 
                565                 570                 575     


Phe Ala Val Leu His Gly Glu Ala Pro Arg Ile Ser Val Ser Phe Tyr 
            580                 585                 590         


His Val Lys Asn Asn Gly Lys Ile Glu Leu Ile Lys Met Phe Asp Lys 
        595                 600                 605             


Gln Gln Ala Asn Thr Ile Phe Trp Ser Pro Gln Gly Gln Phe Val Val 
    610                 615                 620                 


Leu Ala Gly Leu Arg Ser Met Asn Gly Ala Leu Ala Phe Val Asp Thr 
625                 630                 635                 640 


Ser Asp Cys Thr Val Met Asn Ile Ala Glu His Tyr Met Ala Ser Asp 
                645                 650                 655     


Val Glu Trp Asp Pro Thr Gly Arg Tyr Val Val Thr Ser Val Ser Trp 
            660                 665                 670         


Trp Ser His Lys Val Asp Asn Ala Tyr Trp Leu Trp Thr Phe Gln Gly 
        675                 680                 685             


Arg Leu Leu Gln Lys Asn Asn Lys Asp Arg Phe Cys Gln Leu Leu Trp 
    690                 695                 700                 


Arg Pro Arg Pro Pro Thr Leu Leu Ser Gln Glu Gln Ile Lys Gln Ile 
705                 710                 715                 720 


Lys Lys Asp Leu Lys Lys Tyr Ser Lys Ile Phe Glu Gln Lys Asp Arg 
                725                 730                 735     


Leu Ser Gln Ser Lys Ala Ser Lys Glu Leu Val Glu Arg Arg Arg Thr 
            740                 745                 750         


Met Met Glu Asp Phe Arg Lys Tyr Arg Lys Met Ala Gln Glu Leu Tyr 
        755                 760                 765             


Met Glu Gln Lys Asn Glu Arg Leu Glu Leu Arg Gly Gly Val Asp Thr 
    770                 775                 780                 


Asp Glu Leu Asp Ser Asn Val Asp Asp Trp Glu Glu Glu Thr Ile Glu 
785                 790                 795                 800 


Phe Phe Val Thr Glu Glu Ile Ile Pro Leu Gly Asn Gln Glu 
                805                 810                 


<210>  168
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Asp Thr Glu Gly Phe Gly Glu Leu Leu Gln Gln Ala Glu Gln Leu 
1               5                   10                  15      


Ala Ala Glu Thr Glu Gly Ile Ser Glu Leu Pro His Val Glu Arg Asn 
            20                  25                  30          


Leu Gln Glu Ile Gln Gln Ala Gly Glu Arg Leu Arg Ser Arg Thr Leu 
        35                  40                  45              


Thr Arg Thr Ser Gln Glu Thr Ala Asp Val Lys Ala Ser Val Leu Leu 
    50                  55                  60                  


Gly Ser Arg Gly Leu Asp Ile Ser His Ile Ser Gln Arg Leu Glu Ser 
65                  70                  75                  80  


Leu Ser Ala Ala Thr Thr Phe Glu Pro Leu Glu Pro Val Lys Asp Thr 
                85                  90                  95      


Asp Ile Gln Gly Phe Leu Lys Asn Glu Lys Asp Asn Ala Leu Leu Ser 
            100                 105                 110         


Ala Ile Glu Glu Ser Arg Lys Arg Thr Phe Gly Met Ala Glu Glu Tyr 
        115                 120                 125             


His Arg Glu Ser Met Leu Val Glu Trp Glu Gln Val Lys Gln Arg Ile 
    130                 135                 140                 


Leu His Thr Leu Leu Ala Ser Gly Glu Asp Ala Leu Asp Phe Thr Gln 
145                 150                 155                 160 


Glu Ser Glu Pro Ser Tyr Ile Ser Asp Val Gly Pro Pro Gly Arg Ser 
                165                 170                 175     


Ser Leu Asp Asn Ile Glu Met Ala Tyr Ala Arg Gln Ile Tyr Ile Tyr 
            180                 185                 190         


Asn Glu Lys Ile Val Asn Gly His Leu Gln Pro Asn Leu Val Asp Leu 
        195                 200                 205             


Cys Ala Ser Val Ala Glu Leu Asp Asp Lys Ser Ile Ser Asp Met Trp 
    210                 215                 220                 


Thr Met Val Lys Gln Met Thr Asp Val Leu Leu Thr Pro Ala Thr Asp 
225                 230                 235                 240 


Ala Leu Lys Asn Arg Ser Ser Val Glu Val Arg Met Glu Phe Val Arg 
                245                 250                 255     


Gln Ala Leu Ala Tyr Leu Glu Gln Ser Tyr Lys Asn Tyr Thr Leu Val 
            260                 265                 270         


Thr Val Phe Gly Asn Leu His Gln Ala Gln Leu Gly Gly Val Pro Gly 
        275                 280                 285             


Thr Tyr Gln Leu Val Arg Ser Phe Leu Asn Ile Lys Leu Pro Ala Pro 
    290                 295                 300                 


Leu Pro Gly Leu Gln Asp Gly Glu Val Glu Gly His Pro Val Trp Ala 
305                 310                 315                 320 


Leu Ile Tyr Tyr Cys Met Arg Cys Gly Asp Leu Leu Ala Ala Ser Gln 
                325                 330                 335     


Val Val Asn Arg Ala Gln His Gln Leu Gly Glu Phe Lys Thr Trp Phe 
            340                 345                 350         


Gln Glu Tyr Met Asn Ser Lys Asp Arg Arg Leu Ser Pro Ala Thr Glu 
        355                 360                 365             


Asn Lys Leu Arg Leu His Tyr Arg Arg Ala Leu Arg Asn Asn Thr Asp 
    370                 375                 380                 


Pro Tyr Lys Arg Ala Val Tyr Cys Ile Ile Gly Arg Cys Asp Val Thr 
385                 390                 395                 400 


Asp Asn Gln Ser Glu Val Ala Asp Lys Thr Glu Asp Tyr Leu Trp Leu 
                405                 410                 415     


Lys Leu Asn Gln Val Cys Phe Asp Asp Asp Gly Thr Ser Ser Pro Gln 
            420                 425                 430         


Asp Arg Leu Thr Leu Ser Gln Phe Gln Lys Gln Leu Leu Glu Asp Tyr 
        435                 440                 445             


Gly Glu Ser His Phe Thr Val Asn Gln Gln Pro Phe Leu Tyr Phe Gln 
    450                 455                 460                 


Val Leu Phe Leu Thr Ala Gln Phe Glu Ala Ala Val Ala Phe Leu Phe 
465                 470                 475                 480 


Arg Met Glu Arg Leu Arg Cys His Ala Val His Val Ala Leu Val Leu 
                485                 490                 495     


Phe Glu Leu Lys Leu Leu Leu Lys Ser Ser Gly Gln Ser Ala Gln Leu 
            500                 505                 510         


Leu Ser His Glu Pro Gly Asp Pro Pro Cys Leu Arg Arg Leu Asn Phe 
        515                 520                 525             


Val Arg Leu Leu Met Leu Tyr Thr Arg Lys Phe Glu Ser Thr Asp Pro 
    530                 535                 540                 


Arg Glu Ala Leu Gln Tyr Phe Tyr Phe Leu Arg Asp Glu Lys Asp Ser 
545                 550                 555                 560 


Gln Gly Glu Asn Met Phe Leu Arg Cys Val Ser Glu Leu Val Ile Glu 
                565                 570                 575     


Ser Arg Glu Phe Asp Met Ile Leu Gly Lys Leu Glu Asn Asp Gly Ser 
            580                 585                 590         


Arg Lys Pro Gly Val Ile Asp Lys Phe Thr Ser Asp Thr Lys Pro Ile 
        595                 600                 605             


Ile Asn Lys Val Ala Ser Val Ala Glu Asn Lys Gly Leu Phe Glu Glu 
    610                 615                 620                 


Ala Ala Lys Leu Tyr Asp Leu Ala Lys Asn Ala Asp Lys Val Leu Glu 
625                 630                 635                 640 


Leu Met Asn Lys Leu Leu Ser Pro Val Val Pro Gln Ile Ser Ala Pro 
                645                 650                 655     


Gln Ser Asn Lys Glu Arg Leu Lys Asn Met Ala Leu Ser Ile Ala Glu 
            660                 665                 670         


Arg Tyr Arg Ala Gln Gly Ile Ser Ala Asn Lys Phe Val Asp Ser Thr 
        675                 680                 685             


Phe Tyr Leu Leu Leu Asp Leu Ile Thr Phe Phe Asp Glu Tyr His Ser 
    690                 695                 700                 


Gly His Ile Asp Arg Ala Phe Asp Ile Ile Glu Arg Leu Lys Leu Val 
705                 710                 715                 720 


Pro Leu Asn Gln Glu Ser Val Glu Glu Arg Val Ala Ala Phe Arg Asn 
                725                 730                 735     


Phe Ser Asp Glu Ile Arg His Asn Leu Ser Glu Val Leu Leu Ala Thr 
            740                 745                 750         


Met Asn Ile Leu Phe Thr Gln Phe Lys Arg Leu Lys Gly Thr Ser Pro 
        755                 760                 765             


Ser Ser Ser Ser Arg Pro Gln Arg Val Ile Glu Asp Arg Asp Ser Gln 
    770                 775                 780                 


Leu Arg Ser Gln Ala Arg Thr Leu Ile Thr Phe Ala Gly Met Ile Pro 
785                 790                 795                 800 


Tyr Arg Thr Ser Gly Asp Thr Asn Ala Arg Leu Val Gln Met Glu Val 
                805                 810                 815     


Leu Met Asn 
            


<210>  169
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Glu His Tyr Arg Lys Ala Gly Ser Val Glu Leu Pro Ala Pro Ser 
1               5                   10                  15      


Pro Met Pro Gln Leu Pro Pro Asp Thr Leu Glu Met Arg Val Arg Asp 
            20                  25                  30          


Gly Ser Lys Ile Arg Asn Leu Leu Gly Leu Ala Leu Gly Arg Leu Glu 
        35                  40                  45              


Gly Gly Ser Ala Arg His Val Val Phe Ser Gly Ser Gly Arg Ala Ala 
    50                  55                  60                  


Gly Lys Ala Val Ser Cys Ala Glu Ile Val Lys Arg Arg Val Pro Gly 
65                  70                  75                  80  


Leu His Gln Leu Thr Lys Leu Arg Phe Leu Gln Thr Glu Asp Ser Trp 
                85                  90                  95      


Val Pro Ala Ser Pro Asp Thr Gly Leu Asp Pro Leu Thr Val Arg Arg 
            100                 105                 110         


His Val Pro Ala Val Trp Val Leu Leu Ser Arg Asp Pro Leu Asp Pro 
        115                 120                 125             


Asn Glu Cys Gly Tyr Gln Pro Pro Gly Ala Pro Pro Gly Leu Gly Ser 
    130                 135                 140                 


Met Pro Ser Ser Ser Cys Gly Pro Arg Ser Arg Arg Arg Ala Arg Asp 
145                 150                 155                 160 


Thr Arg Ser 
            


<210>  170
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ser Glu Arg Glu Glu Arg Arg Phe Val Glu Ile Pro Arg Glu Ser 
1               5                   10                  15      


Val Arg Leu Met Ala Glu Ser Thr Gly Leu Glu Leu Ser Asp Glu Val 
            20                  25                  30          


Ala Ala Leu Leu Ala Glu Asp Val Cys Tyr Arg Leu Arg Glu Ala Thr 
        35                  40                  45              


Gln Asn Ser Ser Gln Phe Met Lys His Thr Lys Arg Arg Lys Leu Thr 
    50                  55                  60                  


Val Glu Asp Phe Asn Arg Ala Leu Arg Trp Ser Ser Val Glu Ala Val 
65                  70                  75                  80  


Cys Gly Tyr Gly Ser Gln Glu Ala Leu Pro Met Arg Pro Ala Arg Glu 
                85                  90                  95      


Gly Glu Leu Tyr Phe Pro Glu Asp Arg Glu Val Asn Leu Val Glu Leu 
            100                 105                 110         


Ala Leu Ala Thr Asn Ile Pro Lys Gly Cys Ala Glu Thr Ala Val Arg 
        115                 120                 125             


Val His Val Ser Tyr Leu Asp Gly Lys Gly Asn Leu Ala Pro Gln Gly 
    130                 135                 140                 


Ser Val Pro Ser Ala Val Ser Ser Leu Thr Asp Asp Leu Leu Lys Tyr 
145                 150                 155                 160 


Tyr His Gln Val Thr Arg Ala Val Leu Gly Asp Asp Pro Gln Leu Met 
                165                 170                 175     


Lys Val Ala Leu Gln Asp Leu Gln Thr Asn Ser Lys Ile Gly Ala Leu 
            180                 185                 190         


Leu Pro Tyr Phe Val Tyr Val Val Ser Gly Val Lys Ser Val Ser His 
        195                 200                 205             


Asp Leu Glu Gln Leu His Arg Leu Leu Gln Val Ala Arg Ser Leu Phe 
    210                 215                 220                 


Arg Asn Pro His Leu Cys Leu Gly Pro Tyr Val Arg Cys Leu Val Gly 
225                 230                 235                 240 


Ser Val Leu Tyr Cys Val Leu Glu Pro Leu Ala Ala Ser Ile Asn Pro 
                245                 250                 255     


Leu Asn Asp His Trp Thr Leu Arg Asp Gly Ala Ala Leu Leu Leu Ser 
            260                 265                 270         


His Ile Phe Trp Thr His Gly Asp Leu Val Ser Gly Leu Tyr Gln His 
        275                 280                 285             


Ile Leu Leu Ser Leu Gln Lys Ile Leu Ala Asp Pro Val Arg Pro Leu 
    290                 295                 300                 


Cys Cys His Tyr Gly Ala Val Val Gly Leu His Ala Leu Gly Trp Lys 
305                 310                 315                 320 


Ala Val Glu Arg Val Leu Tyr Pro His Leu Ser Thr Tyr Trp Thr Asn 
                325                 330                 335     


Leu Gln Ala Val Leu Asp Asp Tyr Ser Val Ser Asn Ala Gln Val Lys 
            340                 345                 350         


Ala Asp Gly His Lys Val Tyr Gly Ala Ile Leu Val Ala Val Glu Arg 
        355                 360                 365             


Leu Leu Lys Met Lys Ala Gln Ala Ala Glu Pro Asn Arg Gly Gly Pro 
    370                 375                 380                 


Gly Gly Arg Gly Cys Arg Arg Leu Asp Asp Leu Pro Trp Asp Ser Leu 
385                 390                 395                 400 


Leu Phe Gln Glu Ser Ser Ser Gly Gly Gly Ala Glu Pro Ser Phe Gly 
                405                 410                 415     


Ser Gly Leu Pro Leu Pro Pro Gly Gly Ala Gly Pro Glu Asp Pro Ser 
            420                 425                 430         


Leu Ser Val Thr Leu Ala Asp Ile Tyr Arg Glu Leu Tyr Ala Phe Phe 
        435                 440                 445             


Gly Asp Ser Leu Ala Thr Arg Phe Gly Thr Gly Gln Pro Ala Pro Thr 
    450                 455                 460                 


Ala Pro Arg Pro Pro Gly Asp Lys Lys Glu Pro Ala Ala Ala Pro Asp 
465                 470                 475                 480 


Ser Val Arg Lys Met Pro Gln Leu Thr Ala Ser Ala Ile Val Ser Pro 
                485                 490                 495     


His Gly Asp Glu Ser Pro Arg Gly Ser Gly Gly Gly Gly Pro Ala Ser 
            500                 505                 510         


Ala Ser Gly Pro Ala Ala Ser Glu Ser Arg Pro Leu Pro Arg Val His 
        515                 520                 525             


Arg Ala Arg Gly Ala Pro Arg Gln Gln Gly Pro Gly Thr Gly Thr Arg 
    530                 535                 540                 


Asp Val Phe Gln Lys Ser Arg Phe Ala Pro Arg Gly Ala Pro His Phe 
545                 550                 555                 560 


Arg Phe Ile Ile Ala Gly Arg Gln Ala Gly Arg Arg Cys Arg Gly Arg 
                565                 570                 575     


Leu Phe Gln Thr Ala Phe Pro Ala Pro Tyr Gly Pro Ser Pro Ala Ser 
            580                 585                 590         


Arg Tyr Val Gln Lys Leu Pro Met Ile Gly Arg Thr Ser Arg Pro Ala 
        595                 600                 605             


Arg Arg Trp Ala Leu Ser Asp Tyr Ser Leu Tyr Leu Pro Leu 
    610                 615                 620         


<210>  171
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Tyr His Asn Ser Ser Gln Lys Arg His Trp Thr Phe Ser Ser Glu 
1               5                   10                  15      


Glu Gln Leu Ala Arg Leu Arg Ala Asp Ala Asn Arg Lys Phe Arg Cys 
            20                  25                  30          


Lys Ala Val Ala Asn Gly Lys Val Leu Pro Asn Asp Pro Val Phe Leu 
        35                  40                  45              


Glu Pro His Glu Glu Met Thr Leu Cys Lys Tyr Tyr Glu Lys Arg Leu 
    50                  55                  60                  


Leu Glu Phe Cys Ser Val Phe Lys Pro Ala Met Pro Arg Ser Val Val 
65                  70                  75                  80  


Gly Thr Ala Cys Met Tyr Phe Lys Arg Phe Tyr Leu Asn Asn Ser Val 
                85                  90                  95      


Met Glu Tyr His Pro Arg Ile Ile Met Leu Thr Cys Ala Phe Leu Ala 
            100                 105                 110         


Cys Lys Val Asp Glu Phe Asn Val Ser Ser Pro Gln Phe Val Gly Asn 
        115                 120                 125             


Leu Arg Glu Ser Pro Leu Gly Gln Glu Lys Ala Leu Glu Gln Ile Leu 
    130                 135                 140                 


Glu Tyr Glu Leu Leu Leu Ile Gln Gln Leu Asn Phe His Leu Ile Val 
145                 150                 155                 160 


His Asn Pro Tyr Arg Pro Phe Glu Gly Phe Leu Ile Asp Leu Lys Thr 
                165                 170                 175     


Arg Tyr Pro Ile Leu Glu Asn Pro Glu Ile Leu Arg Lys Thr Ala Asp 
            180                 185                 190         


Asp Phe Leu Asn Arg Ile Ala Leu Thr Asp Ala Tyr Leu Leu Tyr Thr 
        195                 200                 205             


Pro Ser Gln Ile Ala Leu Thr Ala Ile Leu Ser Ser Ala Ser Arg Ala 
    210                 215                 220                 


Gly Ile Thr Met Glu Ser Tyr Leu Ser Glu Ser Leu Met Leu Lys Glu 
225                 230                 235                 240 


Asn Arg Thr Cys Leu Ser Gln Leu Leu Asp Ile Met Lys Ser Met Arg 
                245                 250                 255     


Asn Leu Val Lys Lys Tyr Glu Pro Pro Arg Ser Glu Glu Val Ala Val 
            260                 265                 270         


Leu Lys Gln Lys Leu Glu Arg Cys His Ser Ala Glu Leu Ala Leu Asn 
        275                 280                 285             


Val Ile Thr Lys Lys Arg Lys Gly Tyr Glu Asp Asp Asp Tyr Val Ser 
    290                 295                 300                 


Lys Lys Ser Lys His Glu Glu Glu Glu Trp Thr Asp Asp Asp Leu Val 
305                 310                 315                 320 


Glu Ser Leu 
            


<210>  172
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Val Ser Asp Glu Asp Glu Leu Asn Leu Leu Val Ile Val Val Asp 
1               5                   10                  15      


Ala Asn Pro Ile Trp Trp Gly Lys Gln Ala Leu Lys Glu Ser Gln Phe 
            20                  25                  30          


Thr Leu Ser Lys Cys Ile Asp Ala Val Met Val Leu Gly Asn Ser His 
        35                  40                  45              


Leu Phe Met Asn Arg Ser Asn Lys Leu Ala Val Ile Ala Ser His Ile 
    50                  55                  60                  


Gln Glu Ser Arg Phe Leu Tyr Pro Gly Lys Asn Gly Arg Leu Gly Asp 
65                  70                  75                  80  


Phe Phe Gly Asp Pro Gly Asn Pro Pro Glu Phe Asn Pro Ser Gly Ser 
                85                  90                  95      


Lys Asp Gly Lys Tyr Glu Leu Leu Thr Ser Ala Asn Glu Val Ile Val 
            100                 105                 110         


Glu Glu Ile Lys Asp Leu Met Thr Lys Ser Asp Ile Lys Gly Gln His 
        115                 120                 125             


Thr Glu Thr Leu Leu Ala Gly Ser Leu Ala Lys Ala Leu Cys Tyr Ile 
    130                 135                 140                 


His Arg Met Asn Lys Glu Val Lys Asp Asn Gln Glu Met Lys Ser Arg 
145                 150                 155                 160 


Ile Leu Val Ile Lys Ala Ala Glu Asp Ser Ala Leu Gln Tyr Met Asn 
                165                 170                 175     


Phe Met Asn Val Ile Phe Ala Ala Gln Lys Gln Asn Ile Leu Ile Asp 
            180                 185                 190         


Ala Cys Val Leu Asp Ser Asp Ser Gly Leu Leu Gln Gln Ala Cys Asp 
        195                 200                 205             


Ile Thr Gly Gly Leu Tyr Leu Lys Val Pro Gln Met Pro Ser Leu Leu 
    210                 215                 220                 


Gln Tyr Leu Leu Trp Val Phe Leu Pro Asp Gln Asp Gln Arg Ser Gln 
225                 230                 235                 240 


Leu Ile Leu Pro Pro Pro Val His Val Asp Tyr Arg Ala Ala Cys Phe 
                245                 250                 255     


Cys His Arg Asn Leu Ile Glu Ile Gly Tyr Val Cys Ser Val Cys Leu 
            260                 265                 270         


Ser Ile Phe Cys Asn Phe Ser Pro Ile Cys Thr Thr Cys Glu Thr Ala 
        275                 280                 285             


Phe Lys Ile Ser Leu Pro Pro Val Leu Lys Ala Lys Lys Lys Lys Leu 
    290                 295                 300                 


Lys Val Ser Ala 
305             


<210>  173
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ala Ser Thr Ser Arg Leu Asp Ala Leu Pro Arg Val Thr Cys Pro 
1               5                   10                  15      


Asn His Pro Asp Ala Ile Leu Val Glu Asp Tyr Arg Ala Gly Asp Met 
            20                  25                  30          


Ile Cys Pro Glu Cys Gly Leu Val Val Gly Asp Arg Val Ile Asp Val 
        35                  40                  45              


Gly Ser Glu Trp Arg Thr Phe Ser Asn Asp Lys Ala Thr Lys Asp Pro 
    50                  55                  60                  


Ser Arg Val Gly Asp Ser Gln Asn Pro Leu Leu Ser Asp Gly Asp Leu 
65                  70                  75                  80  


Ser Thr Met Ile Gly Lys Gly Thr Gly Ala Ala Ser Phe Asp Glu Phe 
                85                  90                  95      


Gly Asn Ser Lys Tyr Gln Asn Arg Arg Thr Met Ser Ser Ser Asp Arg 
            100                 105                 110         


Ala Met Met Asn Ala Phe Lys Glu Ile Thr Thr Met Ala Asp Arg Ile 
        115                 120                 125             


Asn Leu Pro Arg Asn Ile Val Asp Arg Thr Asn Asn Leu Phe Lys Gln 
    130                 135                 140                 


Val Tyr Glu Gln Lys Ser Leu Lys Gly Arg Ala Asn Asp Ala Ile Ala 
145                 150                 155                 160 


Ser Ala Cys Leu Tyr Ile Ala Cys Arg Gln Glu Gly Val Pro Arg Thr 
                165                 170                 175     


Phe Lys Glu Ile Cys Ala Val Ser Arg Ile Ser Lys Lys Glu Ile Gly 
            180                 185                 190         


Arg Cys Phe Lys Leu Ile Leu Lys Ala Leu Glu Thr Ser Val Asp Leu 
        195                 200                 205             


Ile Thr Thr Gly Asp Phe Met Ser Arg Phe Cys Ser Asn Leu Cys Leu 
    210                 215                 220                 


Pro Lys Gln Val Gln Met Ala Ala Thr His Ile Ala Arg Lys Ala Val 
225                 230                 235                 240 


Glu Leu Asp Leu Val Pro Gly Arg Ser Pro Ile Ser Val Ala Ala Ala 
                245                 250                 255     


Ala Ile Tyr Met Ala Ser Gln Ala Ser Ala Glu Lys Arg Thr Gln Lys 
            260                 265                 270         


Glu Ile Gly Asp Ile Ala Gly Val Ala Asp Val Thr Ile Arg Gln Ser 
        275                 280                 285             


Tyr Arg Leu Ile Tyr Pro Arg Ala Pro Asp Leu Phe Pro Thr Asp Phe 
    290                 295                 300                 


Lys Phe Asp Thr Pro Val Asp Lys Leu Pro Gln Leu 
305                 310                 315     


<210>  174
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ala Glu Arg Gly Glu Leu Asp Leu Thr Gly Ala Lys Gln Asn Thr 
1               5                   10                  15      


Gly Val Trp Leu Val Lys Val Pro Lys Tyr Leu Ser Gln Gln Trp Ala 
            20                  25                  30          


Lys Ala Ser Gly Arg Gly Glu Val Gly Lys Leu Arg Ile Ala Lys Thr 
        35                  40                  45              


Gln Gly Arg Thr Glu Val Ser Phe Thr Leu Asn Glu Asp Leu Ala Asn 
    50                  55                  60                  


Ile His Asp Ile Gly Gly Lys Pro Ala Ser Val Ser Ala Pro Arg Glu 
65                  70                  75                  80  


His Pro Phe Val Leu Gln Ser Val Gly Gly Gln Thr Leu Thr Val Phe 
                85                  90                  95      


Thr Glu Ser Ser Ser Asp Lys Leu Ser Leu Glu Gly Ile Val Val Gln 
            100                 105                 110         


Arg Ala Glu Cys Arg Pro Ala Ala Ser Glu Asn Tyr Met Arg Leu Lys 
        115                 120                 125             


Arg Leu Gln Ile Glu Glu Ser Ser Lys Pro Val Arg Leu Ser Gln Gln 
    130                 135                 140                 


Leu Asp Lys Val Val Thr Thr Asn Tyr Lys Pro Val Ala Asn His Gln 
145                 150                 155                 160 


Tyr Asn Ile Glu Tyr Glu Arg Lys Lys Lys Glu Asp Gly Lys Arg Ala 
                165                 170                 175     


Arg Ala Asp Lys Gln His Val Leu Asp Met Leu Phe Ser Ala Phe Glu 
            180                 185                 190         


Lys His Gln Tyr Tyr Asn Leu Lys Asp Leu Val Asp Ile Thr Lys Gln 
        195                 200                 205             


Pro Val Val Tyr Leu Lys Glu Ile Leu Lys Glu Ile Gly Val Gln Asn 
    210                 215                 220                 


Val Lys Gly Ile His Lys Asn Thr Trp Glu Leu Lys Pro Glu Tyr Arg 
225                 230                 235                 240 


His Tyr Gln Gly Glu Glu Lys Ser Asp 
                245                 


<210>  175
<211>  929
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Cys Glu Ser Tyr Ser Arg Ser Leu Leu Arg Val Ser Val Ala Gln 
1               5                   10                  15      


Ile Cys Gln Ala Leu Gly Trp Asp Ser Val Gln Leu Ser Ala Cys His 
            20                  25                  30          


Leu Leu Thr Asp Val Leu Gln Arg Tyr Leu Gln Gln Leu Gly Arg Gly 
        35                  40                  45              


Cys His Arg Tyr Ser Glu Leu Tyr Gly Arg Thr Asp Pro Ile Leu Asp 
    50                  55                  60                  


Asp Val Gly Glu Ala Phe Gln Leu Met Gly Val Ser Leu His Glu Leu 
65                  70                  75                  80  


Glu Asp Tyr Ile His Asn Ile Glu Pro Val Thr Phe Pro His Gln Ile 
                85                  90                  95      


Pro Ser Phe Pro Val Ser Lys Asn Asn Val Leu Gln Phe Pro Gln Pro 
            100                 105                 110         


Gly Ser Lys Asp Ala Glu Glu Arg Lys Glu Tyr Ile Pro Asp Tyr Leu 
        115                 120                 125             


Pro Pro Ile Val Ser Ser Gln Glu Glu Glu Glu Glu Glu Gln Val Pro 
    130                 135                 140                 


Thr Asp Gly Gly Thr Ser Ala Glu Ala Met Gln Val Pro Leu Glu Glu 
145                 150                 155                 160 


Asp Asp Glu Leu Glu Glu Glu Glu Ile Ile Asn Asp Glu Asn Phe Leu 
                165                 170                 175     


Gly Lys Arg Pro Leu Asp Ser Pro Glu Ala Glu Glu Leu Pro Ala Met 
            180                 185                 190         


Lys Arg Pro Arg Leu Leu Ser Thr Lys Gly Asp Thr Leu Asp Val Val 
        195                 200                 205             


Leu Leu Glu Ala Arg Glu Pro Leu Ser Ser Ile Asn Thr Gln Lys Ile 
    210                 215                 220                 


Pro Pro Met Leu Ser Pro Val His Val Gln Asp Ser Thr Asp Leu Ala 
225                 230                 235                 240 


Pro Pro Ser Pro Glu Pro Pro Met Leu Ala Pro Val Ala Lys Ser Gln 
                245                 250                 255     


Met Pro Thr Ala Lys Pro Leu Glu Thr Lys Ser Phe Thr Pro Lys Thr 
            260                 265                 270         


Lys Thr Lys Thr Ser Ser Pro Gly Gln Lys Thr Lys Ser Pro Lys Thr 
        275                 280                 285             


Ala Gln Ser Pro Ala Met Val Gly Ser Pro Ile Arg Ser Pro Lys Thr 
    290                 295                 300                 


Val Ser Lys Glu Lys Lys Ser Pro Gly Arg Ser Lys Ser Pro Lys Ser 
305                 310                 315                 320 


Pro Lys Ser Pro Lys Val Thr Thr His Ile Pro Gln Thr Pro Val Arg 
                325                 330                 335     


Pro Glu Thr Pro Asn Arg Thr Pro Ser Ala Thr Leu Ser Glu Lys Ile 
            340                 345                 350         


Ser Lys Glu Thr Ile Gln Val Lys Gln Ile Gln Thr Pro Pro Asp Ala 
        355                 360                 365             


Gly Lys Leu Asn Ser Glu Asn Gln Pro Lys Lys Ala Val Val Ala Asp 
    370                 375                 380                 


Lys Thr Ile Glu Ala Ser Ile Asp Ala Val Ile Ala Arg Ala Cys Ala 
385                 390                 395                 400 


Glu Arg Glu Pro Asp Pro Phe Glu Phe Ser Ser Gly Ser Glu Ser Glu 
                405                 410                 415     


Gly Asp Ile Phe Thr Ser Pro Lys Arg Ile Ser Gly Pro Glu Cys Thr 
            420                 425                 430         


Thr Pro Lys Ala Ser Thr Ser Ala Asn Asn Phe Thr Lys Ser Gly Ser 
        435                 440                 445             


Thr Pro Leu Pro Leu Ser Gly Gly Thr Ser Ser Ser Asp Asn Ser Trp 
    450                 455                 460                 


Thr Met Asp Ala Ser Ile Asp Glu Val Val Arg Lys Ala Lys Leu Gly 
465                 470                 475                 480 


Thr Pro Ser Asn Met Pro Pro Asn Phe Pro Tyr Ile Ser Ser Pro Ser 
                485                 490                 495     


Val Ser Pro Pro Thr Pro Glu Pro Leu His Lys Val Tyr Glu Glu Lys 
            500                 505                 510         


Thr Lys Leu Pro Ser Ser Val Glu Val Lys Lys Lys Leu Lys Lys Glu 
        515                 520                 525             


Leu Lys Thr Lys Met Lys Lys Lys Glu Lys Gln Arg Asp Arg Glu Arg 
    530                 535                 540                 


Glu Lys Asp Lys Asn Lys Asp Lys Ser Lys Glu Lys Asp Lys Val Lys 
545                 550                 555                 560 


Glu Lys Glu Lys Asp Lys Glu Thr Gly Arg Glu Thr Lys Tyr Pro Trp 
                565                 570                 575     


Lys Glu Phe Leu Lys Glu Glu Glu Ala Asp Pro Tyr Lys Phe Lys Ile 
            580                 585                 590         


Lys Glu Phe Glu Asp Val Asp Pro Lys Val Lys Leu Lys Asp Gly Leu 
        595                 600                 605             


Val Arg Lys Glu Lys Glu Lys His Lys Asp Lys Lys Lys Asp Arg Glu 
    610                 615                 620                 


Lys Gly Lys Lys Asp Lys Asp Lys Arg Glu Lys Glu Lys Val Lys Asp 
625                 630                 635                 640 


Lys Gly Arg Glu Asp Lys Met Lys Ala Pro Ala Pro Pro Leu Val Leu 
                645                 650                 655     


Pro Pro Lys Glu Leu Ala Leu Pro Leu Phe Ser Pro Ala Thr Ala Ser 
            660                 665                 670         


Arg Val Pro Ala Met Leu Pro Ser Leu Leu Pro Val Leu Pro Glu Lys 
        675                 680                 685             


Leu Phe Glu Glu Lys Glu Lys Val Lys Glu Lys Glu Lys Lys Lys Asp 
    690                 695                 700                 


Lys Lys Glu Lys Lys Lys Lys Lys Glu Lys Glu Lys Glu Lys Lys Glu 
705                 710                 715                 720 


Lys Glu Arg Glu Lys Glu Lys Arg Glu Arg Glu Lys Arg Glu Lys Glu 
                725                 730                 735     


Lys Glu Lys His Lys His Glu Lys Ile Lys Val Glu Pro Val Ala Leu 
            740                 745                 750         


Ala Pro Ser Pro Val Ile Pro Arg Leu Thr Leu Arg Val Gly Ala Gly 
        755                 760                 765             


Gln Asp Lys Ile Val Ile Ser Lys Val Val Pro Ala Pro Glu Ala Lys 
    770                 775                 780                 


Pro Ala Pro Ser Gln Asn Arg Pro Lys Thr Pro Pro Pro Ala Pro Ala 
785                 790                 795                 800 


Pro Ala Pro Gly Pro Met Leu Val Ser Pro Ala Pro Val Pro Leu Pro 
                805                 810                 815     


Leu Leu Ala Gln Ala Ala Ala Gly Pro Ala Leu Leu Pro Ser Pro Gly 
            820                 825                 830         


Pro Ala Ala Ser Gly Ala Ser Ala Lys Ala Pro Val Arg Ser Val Val 
        835                 840                 845             


Thr Glu Thr Val Ser Thr Tyr Val Ile Arg Asp Glu Trp Gly Asn Gln 
    850                 855                 860                 


Ile Trp Ile Cys Pro Gly Cys Asn Lys Pro Asp Asp Gly Ser Pro Met 
865                 870                 875                 880 


Ile Gly Cys Asp Asp Cys Asp Asp Trp Tyr His Trp Pro Cys Val Gly 
                885                 890                 895     


Ile Met Thr Ala Pro Pro Glu Glu Met Gln Trp Phe Cys Pro Lys Cys 
            900                 905                 910         


Ala Asn Lys Lys Lys Asp Lys Lys His Lys Lys Arg Lys His Arg Ala 
        915                 920                 925             


His 
    


<210>  176
<211>  1199
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Pro Leu Thr Gly Val Glu Pro Ala Arg Met Asn Arg Lys Lys Gly 
1               5                   10                  15      


Asp Lys Gly Phe Glu Ser Pro Arg Pro Tyr Lys Leu Thr His Gln Val 
            20                  25                  30          


Val Cys Ile Asn Asn Ile Asn Phe Gln Arg Lys Ser Val Val Gly Phe 
        35                  40                  45              


Val Glu Leu Thr Ile Phe Pro Thr Val Ala Asn Leu Asn Arg Ile Lys 
    50                  55                  60                  


Leu Asn Ser Lys Gln Cys Arg Ile Tyr Arg Val Arg Ile Asn Asp Leu 
65                  70                  75                  80  


Glu Ala Ala Phe Ile Tyr Asn Asp Pro Thr Leu Glu Val Cys His Ser 
                85                  90                  95      


Glu Ser Lys Gln Arg Asn Leu Asn Tyr Phe Ser Asn Ala Tyr Ala Ala 
            100                 105                 110         


Ala Val Ser Ala Val Asp Pro Asp Ala Gly Asn Gly Glu Leu Cys Ile 
        115                 120                 125             


Lys Val Pro Ser Glu Leu Trp Lys His Val Asp Glu Leu Lys Val Leu 
    130                 135                 140                 


Lys Ile His Ile Asn Phe Ser Leu Asp Gln Pro Lys Gly Gly Leu His 
145                 150                 155                 160 


Phe Val Val Pro Ser Val Glu Gly Ser Met Ala Glu Arg Gly Ala His 
                165                 170                 175     


Val Phe Ser Cys Gly Tyr Gln Asn Ser Thr Arg Phe Trp Phe Pro Cys 
            180                 185                 190         


Val Asp Ser Tyr Ser Glu Leu Cys Thr Trp Lys Leu Glu Phe Thr Val 
        195                 200                 205             


Asp Ala Ala Met Val Ala Val Ser Asn Gly Asp Leu Val Glu Thr Val 
    210                 215                 220                 


Tyr Thr His Asp Met Arg Lys Lys Thr Phe His Tyr Met Leu Thr Ile 
225                 230                 235                 240 


Pro Thr Ala Ala Ser Asn Ile Ser Leu Ala Ile Gly Pro Phe Glu Ile 
                245                 250                 255     


Leu Val Asp Pro Tyr Met His Glu Val Thr His Phe Cys Leu Pro Gln 
            260                 265                 270         


Leu Leu Pro Leu Leu Lys His Thr Thr Ser Tyr Leu His Glu Val Phe 
        275                 280                 285             


Glu Phe Tyr Glu Glu Ile Leu Thr Cys Arg Tyr Pro Tyr Ser Cys Phe 
    290                 295                 300                 


Lys Thr Val Phe Ile Asp Glu Ala Tyr Val Glu Val Ala Ala Tyr Ala 
305                 310                 315                 320 


Ser Met Ser Ile Phe Ser Thr Asn Leu Leu His Ser Ala Met Ile Ile 
                325                 330                 335     


Asp Glu Thr Pro Leu Thr Arg Arg Cys Leu Ala Gln Ser Leu Ala Gln 
            340                 345                 350         


Gln Phe Phe Gly Cys Phe Ile Ser Arg Met Ser Trp Ser Asp Glu Trp 
        355                 360                 365             


Val Leu Lys Gly Ile Ser Gly Tyr Ile Tyr Gly Leu Trp Met Lys Lys 
    370                 375                 380                 


Thr Phe Gly Val Asn Glu Tyr Arg His Trp Ile Lys Glu Glu Leu Asp 
385                 390                 395                 400 


Lys Ile Val Ala Tyr Glu Leu Lys Thr Gly Gly Val Leu Leu His Pro 
                405                 410                 415     


Ile Phe Gly Gly Gly Lys Glu Lys Asp Asn Pro Ala Ser His Leu His 
            420                 425                 430         


Phe Ser Ile Lys His Pro His Thr Leu Ser Trp Glu Tyr Tyr Ser Met 
        435                 440                 445             


Phe Gln Cys Lys Ala His Leu Val Met Arg Leu Ile Glu Asn Arg Ile 
    450                 455                 460                 


Ser Met Glu Phe Met Leu Gln Val Phe Asn Lys Leu Leu Ser Leu Ala 
465                 470                 475                 480 


Ser Thr Ala Ser Ser Gln Lys Phe Gln Ser His Met Trp Ser Gln Met 
                485                 490                 495     


Leu Val Ser Thr Ser Gly Phe Leu Lys Ser Ile Ser Asn Val Ser Gly 
            500                 505                 510         


Lys Asp Ile Gln Pro Leu Ile Lys Gln Trp Val Asp Gln Ser Gly Val 
        515                 520                 525             


Val Lys Phe Tyr Gly Ser Phe Ala Phe Asn Arg Lys Arg Asn Val Leu 
    530                 535                 540                 


Glu Leu Glu Ile Lys Gln Asp Tyr Thr Ser Pro Gly Thr Gln Lys Tyr 
545                 550                 555                 560 


Val Gly Pro Leu Lys Val Thr Val Gln Glu Leu Asp Gly Ser Phe Asn 
                565                 570                 575     


His Thr Leu Gln Ile Glu Glu Asn Ser Leu Lys His Asp Ile Pro Cys 
            580                 585                 590         


His Ser Lys Ser Arg Arg Asn Lys Lys Lys Lys Ile Pro Leu Met Asn 
        595                 600                 605             


Gly Glu Glu Val Asp Met Asp Leu Ser Ala Met Asp Ala Asp Ser Pro 
    610                 615                 620                 


Leu Leu Trp Ile Arg Ile Asp Pro Asp Met Ser Val Leu Arg Lys Val 
625                 630                 635                 640 


Glu Phe Glu Gln Ala Asp Phe Met Trp Gln Tyr Gln Leu Arg Tyr Glu 
                645                 650                 655     


Arg Asp Val Val Ala Gln Gln Glu Ser Ile Leu Ala Leu Glu Lys Phe 
            660                 665                 670         


Pro Thr Pro Ala Ser Arg Leu Ala Leu Thr Asp Ile Leu Glu Gln Glu 
        675                 680                 685             


Gln Cys Phe Tyr Arg Val Arg Met Ser Ala Cys Phe Cys Leu Ala Lys 
    690                 695                 700                 


Ile Ala Asn Ser Met Val Ser Thr Trp Thr Gly Pro Pro Ala Met Lys 
705                 710                 715                 720 


Ser Leu Phe Thr Arg Met Phe Cys Cys Lys Ser Cys Pro Asn Ile Val 
                725                 730                 735     


Lys Thr Asn Asn Phe Met Ser Phe Gln Ser Tyr Phe Leu Gln Lys Thr 
            740                 745                 750         


Met Pro Val Ala Met Ala Leu Leu Arg Asp Val His Asn Leu Cys Pro 
        755                 760                 765             


Lys Glu Val Leu Thr Phe Ile Leu Asp Leu Ile Lys Tyr Asn Asp Asn 
    770                 775                 780                 


Arg Lys Asn Lys Phe Ser Asp Asn Tyr Tyr Arg Ala Glu Met Ile Asp 
785                 790                 795                 800 


Ala Leu Ala Asn Ser Val Thr Pro Ala Val Ser Val Asn Asn Glu Val 
                805                 810                 815     


Arg Thr Leu Asp Asn Leu Asn Pro Asp Val Arg Leu Ile Leu Glu Glu 
            820                 825                 830         


Ile Thr Arg Phe Leu Asn Met Glu Lys Leu Leu Pro Ser Tyr Arg His 
        835                 840                 845             


Thr Ile Thr Val Ser Cys Leu Arg Ala Ile Arg Val Leu Gln Lys Asn 
    850                 855                 860                 


Gly His Val Pro Ser Asp Pro Ala Leu Phe Lys Ser Tyr Ala Glu Tyr 
865                 870                 875                 880 


Gly His Phe Val Asp Ile Arg Ile Ala Ala Leu Glu Ala Val Val Asp 
                885                 890                 895     


Tyr Thr Lys Val Asp Arg Ser Tyr Glu Glu Leu Gln Trp Leu Leu Asn 
            900                 905                 910         


Met Ile Gln Asn Asp Pro Val Pro Tyr Val Arg His Lys Ile Leu Asn 
        915                 920                 925             


Met Leu Thr Lys Asn Pro Pro Phe Thr Lys Asn Met Glu Ser Pro Leu 
    930                 935                 940                 


Cys Asn Glu Ala Leu Val Asp Gln Leu Trp Lys Leu Met Asn Ser Gly 
945                 950                 955                 960 


Thr Ser His Asp Trp Arg Leu Arg Cys Gly Ala Val Asp Leu Tyr Phe 
                965                 970                 975     


Thr Leu Phe Gly Leu Ser Arg Pro Ser Cys Leu Pro Leu Pro Glu Leu 
            980                 985                 990         


Gly Leu Val Leu Asn Leu Lys Glu  Lys Lys Ala Val Leu  Asn Pro Thr 
        995                 1000                 1005             


Ile Ile  Pro Glu Ser Val Ala  Gly Asn Gln Glu Ala  Ala Asn Asn 
    1010                 1015                 1020             


Pro Ser  Ser His Pro Gln Leu  Val Gly Phe Gln Asn  Pro Phe Ser 
    1025                 1030                 1035             


Ser Ser  Gln Asp Glu Glu Glu  Ile Asp Met Asp Thr  Val His Asp 
    1040                 1045                 1050             


Ser Gln  Ala Phe Ile Ser His  His Leu Asn Met Leu  Glu Arg Pro 
    1055                 1060                 1065             


Ser Thr  Pro Gly Leu Ser Lys  Tyr Arg Pro Ala Ser  Ser Arg Ser 
    1070                 1075                 1080             


Ala Leu  Ile Pro Gln His Ser  Ala Gly Cys Asp Ser  Thr Pro Thr 
    1085                 1090                 1095             


Thr Lys  Pro Gln Trp Ser Leu  Glu Leu Ala Arg Lys  Gly Thr Gly 
    1100                 1105                 1110             


Lys Glu  Gln Ala Pro Leu Glu  Met Ser Met His Pro  Ala Ala Ser 
    1115                 1120                 1125             


Ala Pro  Leu Ser Val Phe Thr  Lys Glu Ser Thr Ala  Ser Lys His 
    1130                 1135                 1140             


Ser Asp  His His His His His  His His Glu His Lys  Lys Lys Lys 
    1145                 1150                 1155             


Lys Lys  His Lys His Lys His  Lys His Lys His Lys  His Asp Ser 
    1160                 1165                 1170             


Lys Glu  Lys Asp Lys Glu Pro  Phe Thr Phe Ser Ser  Pro Ala Ser 
    1175                 1180                 1185             


Gly Arg  Ser Ile Arg Ser Pro  Ser Leu Ser Asp 
    1190                 1195                 


<210>  177
<211>  1872
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Gly Pro Gly Cys Asp Leu Leu Leu Arg Thr Ala Ala Thr Ile Thr 
1               5                   10                  15      


Ala Ala Ala Ile Met Ser Asp Thr Asp Ser Asp Glu Asp Ser Ala Gly 
            20                  25                  30          


Gly Gly Pro Phe Ser Leu Ala Gly Phe Leu Phe Gly Asn Ile Asn Gly 
        35                  40                  45              


Ala Gly Gln Leu Glu Gly Glu Ser Val Leu Asp Asp Glu Cys Lys Lys 
    50                  55                  60                  


His Leu Ala Gly Leu Gly Ala Leu Gly Leu Gly Ser Leu Ile Thr Glu 
65                  70                  75                  80  


Leu Thr Ala Asn Glu Glu Leu Thr Gly Thr Asp Gly Ala Leu Val Asn 
                85                  90                  95      


Asp Glu Gly Trp Val Arg Ser Thr Glu Asp Ala Val Asp Tyr Ser Asp 
            100                 105                 110         


Ile Asn Glu Val Ala Glu Asp Glu Ser Arg Arg Tyr Gln Gln Thr Met 
        115                 120                 125             


Gly Ser Leu Gln Pro Leu Cys His Ser Asp Tyr Asp Glu Asp Asp Tyr 
    130                 135                 140                 


Asp Ala Asp Cys Glu Asp Ile Asp Cys Lys Leu Met Pro Pro Pro Pro 
145                 150                 155                 160 


Pro Pro Pro Gly Pro Met Lys Lys Asp Lys Asp Gln Asp Ser Ile Thr 
                165                 170                 175     


Gly Glu Lys Val Asp Phe Ser Ser Ser Ser Asp Ser Glu Ser Glu Met 
            180                 185                 190         


Gly Pro Gln Glu Ala Thr Gln Ala Glu Ser Glu Asp Gly Lys Leu Thr 
        195                 200                 205             


Leu Pro Leu Ala Gly Ile Met Gln His Asp Ala Thr Lys Leu Leu Pro 
    210                 215                 220                 


Ser Val Thr Glu Leu Phe Pro Glu Phe Arg Pro Gly Lys Val Leu Arg 
225                 230                 235                 240 


Phe Leu Arg Leu Phe Gly Pro Gly Lys Asn Val Pro Ser Val Trp Arg 
                245                 250                 255     


Ser Ala Arg Arg Lys Arg Lys Lys Lys His Arg Glu Leu Ile Gln Glu 
            260                 265                 270         


Glu Gln Ile Gln Glu Val Glu Cys Ser Val Glu Ser Glu Val Ser Gln 
        275                 280                 285             


Lys Ser Leu Trp Asn Tyr Asp Tyr Ala Pro Pro Pro Pro Pro Glu Gln 
    290                 295                 300                 


Cys Leu Ser Asp Asp Glu Ile Thr Met Met Ala Pro Val Glu Ser Lys 
305                 310                 315                 320 


Phe Ser Gln Ser Thr Gly Asp Ile Asp Lys Val Thr Asp Thr Lys Pro 
                325                 330                 335     


Arg Val Ala Glu Trp Arg Tyr Gly Pro Ala Arg Leu Trp Tyr Asp Met 
            340                 345                 350         


Leu Gly Val Pro Glu Asp Gly Ser Gly Phe Asp Tyr Gly Phe Lys Leu 
        355                 360                 365             


Arg Lys Thr Glu His Glu Pro Val Ile Lys Ser Arg Met Ile Glu Glu 
    370                 375                 380                 


Phe Arg Lys Leu Glu Glu Asn Asn Gly Thr Asp Leu Leu Ala Asp Glu 
385                 390                 395                 400 


Asn Phe Leu Met Val Thr Gln Leu His Trp Glu Asp Asp Ile Ile Trp 
                405                 410                 415     


Asp Gly Glu Asp Val Lys His Lys Gly Thr Lys Pro Gln Arg Ala Ser 
            420                 425                 430         


Leu Ala Gly Trp Leu Pro Ser Ser Met Thr Arg Asn Ala Met Ala Tyr 
        435                 440                 445             


Asn Val Gln Gln Gly Phe Ala Ala Thr Leu Asp Asp Asp Lys Pro Trp 
    450                 455                 460                 


Tyr Ser Ile Phe Pro Ile Asp Asn Glu Asp Leu Val Tyr Gly Arg Trp 
465                 470                 475                 480 


Glu Asp Asn Ile Ile Trp Asp Ala Gln Ala Met Pro Arg Leu Leu Glu 
                485                 490                 495     


Pro Pro Val Leu Thr Leu Asp Pro Asn Asp Glu Asn Leu Ile Leu Glu 
            500                 505                 510         


Ile Pro Asp Glu Lys Glu Glu Ala Thr Ser Asn Ser Pro Ser Lys Glu 
        515                 520                 525             


Ser Lys Lys Glu Ser Ser Leu Lys Lys Ser Arg Ile Leu Leu Gly Lys 
    530                 535                 540                 


Thr Gly Val Ile Lys Glu Glu Pro Gln Gln Asn Met Ser Gln Pro Glu 
545                 550                 555                 560 


Val Lys Asp Pro Trp Asn Leu Ser Asn Asp Glu Tyr Tyr Tyr Pro Lys 
                565                 570                 575     


Gln Gln Gly Leu Arg Gly Thr Phe Gly Gly Asn Ile Ile Gln His Ser 
            580                 585                 590         


Ile Pro Ala Val Glu Leu Arg Gln Pro Phe Phe Pro Thr His Met Gly 
        595                 600                 605             


Pro Ile Lys Leu Arg Gln Phe His Arg Pro Pro Leu Lys Lys Tyr Ser 
    610                 615                 620                 


Phe Gly Ala Leu Ser Gln Pro Gly Pro His Ser Val Gln Pro Leu Leu 
625                 630                 635                 640 


Lys His Ile Lys Lys Lys Ala Lys Met Arg Glu Gln Glu Arg Gln Ala 
                645                 650                 655     


Ser Gly Gly Gly Glu Met Phe Phe Met Arg Thr Pro Gln Asp Leu Thr 
            660                 665                 670         


Gly Lys Asp Gly Asp Leu Ile Leu Ala Glu Tyr Ser Glu Glu Asn Gly 
        675                 680                 685             


Pro Leu Met Met Gln Val Gly Met Ala Thr Lys Ile Lys Asn Tyr Tyr 
    690                 695                 700                 


Lys Arg Lys Pro Gly Lys Asp Pro Gly Ala Pro Asp Cys Lys Tyr Gly 
705                 710                 715                 720 


Glu Thr Val Tyr Cys His Thr Ser Pro Phe Leu Gly Ser Leu His Pro 
                725                 730                 735     


Gly Gln Leu Leu Gln Ala Phe Glu Asn Asn Leu Phe Arg Ala Pro Ile 
            740                 745                 750         


Tyr Leu His Lys Met Pro Glu Thr Asp Phe Leu Ile Ile Arg Thr Arg 
        755                 760                 765             


Gln Gly Tyr Tyr Ile Arg Glu Leu Val Asp Ile Phe Val Val Gly Gln 
    770                 775                 780                 


Gln Cys Pro Leu Phe Glu Val Pro Gly Pro Asn Ser Lys Arg Ala Asn 
785                 790                 795                 800 


Thr His Ile Arg Asp Phe Leu Gln Val Phe Ile Tyr Arg Leu Phe Trp 
                805                 810                 815     


Lys Ser Lys Asp Arg Pro Arg Arg Ile Arg Met Glu Asp Ile Lys Lys 
            820                 825                 830         


Ala Phe Pro Ser His Ser Glu Ser Ser Ile Arg Lys Arg Leu Lys Leu 
        835                 840                 845             


Cys Ala Asp Phe Lys Arg Thr Gly Met Asp Ser Asn Trp Trp Val Leu 
    850                 855                 860                 


Lys Ser Asp Phe Arg Leu Pro Thr Glu Glu Glu Ile Arg Ala Met Val 
865                 870                 875                 880 


Ser Pro Glu Gln Cys Cys Ala Tyr Tyr Ser Met Ile Ala Ala Glu Gln 
                885                 890                 895     


Arg Leu Lys Asp Ala Gly Tyr Gly Glu Lys Ser Phe Phe Ala Pro Glu 
            900                 905                 910         


Glu Glu Asn Glu Glu Asp Phe Gln Met Lys Ile Asp Asp Glu Val Arg 
        915                 920                 925             


Thr Ala Pro Trp Asn Thr Thr Arg Ala Phe Ile Ala Ala Met Lys Gly 
    930                 935                 940                 


Lys Cys Leu Leu Glu Val Thr Gly Val Ala Asp Pro Thr Gly Cys Gly 
945                 950                 955                 960 


Glu Gly Phe Ser Tyr Val Lys Ile Pro Asn Lys Pro Thr Gln Gln Lys 
                965                 970                 975     


Asp Asp Lys Glu Pro Gln Pro Val Lys Lys Thr Val Thr Gly Thr Asp 
            980                 985                 990         


Ala Asp Leu Arg Arg Leu Ser Leu  Lys Asn Ala Lys Gln  Leu Leu Arg 
        995                 1000                 1005             


Lys Phe  Gly Val Pro Glu Glu  Glu Ile Lys Lys Leu  Ser Arg Trp 
    1010                 1015                 1020             


Glu Val  Ile Asp Val Val Arg  Thr Met Ser Thr Glu  Gln Ala Arg 
    1025                 1030                 1035             


Ser Gly  Glu Gly Pro Met Ser  Lys Phe Ala Arg Gly  Ser Arg Phe 
    1040                 1045                 1050             


Ser Val  Ala Glu His Gln Glu  Arg Tyr Lys Glu Glu  Cys Gln Arg 
    1055                 1060                 1065             


Ile Phe  Asp Leu Gln Asn Lys  Val Leu Ser Ser Thr  Glu Val Leu 
    1070                 1075                 1080             


Ser Thr  Asp Thr Asp Ser Ser  Ser Ala Glu Asp Ser  Asp Phe Glu 
    1085                 1090                 1095             


Glu Met  Gly Lys Asn Ile Glu  Asn Met Leu Gln Asn  Lys Lys Thr 
    1100                 1105                 1110             


Ser Ser  Gln Leu Ser Arg Glu  Arg Glu Glu Gln Glu  Arg Lys Glu 
    1115                 1120                 1125             


Leu Gln  Arg Met Leu Leu Ala  Ala Gly Ser Ala Ala  Ser Gly Asn 
    1130                 1135                 1140             


Asn His  Arg Asp Asp Asp Thr  Ala Ser Val Thr Ser  Leu Asn Ser 
    1145                 1150                 1155             


Ser Ala  Thr Gly Arg Cys Leu  Lys Ile Tyr Arg Thr  Phe Arg Asp 
    1160                 1165                 1170             


Glu Glu  Gly Lys Glu Tyr Val  Arg Cys Glu Thr Val  Arg Lys Pro 
    1175                 1180                 1185             


Ala Val  Ile Asp Ala Tyr Val  Arg Ile Arg Thr Thr  Lys Asp Glu 
    1190                 1195                 1200             


Glu Phe  Ile Arg Lys Phe Ala  Leu Phe Asp Glu Gln  His Arg Glu 
    1205                 1210                 1215             


Glu Met  Arg Lys Glu Arg Arg  Arg Ile Gln Glu Gln  Leu Arg Arg 
    1220                 1225                 1230             


Leu Lys  Arg Asn Gln Glu Lys  Glu Lys Leu Lys Gly  Pro Pro Glu 
    1235                 1240                 1245             


Lys Lys  Pro Lys Lys Met Lys  Glu Arg Pro Asp Leu  Lys Leu Lys 
    1250                 1255                 1260             


Cys Gly  Ala Cys Gly Ala Ile  Gly His Met Arg Thr  Asn Lys Phe 
    1265                 1270                 1275             


Cys Pro  Leu Tyr Tyr Gln Thr  Asn Ala Pro Pro Ser  Asn Pro Val 
    1280                 1285                 1290             


Ala Met  Thr Glu Glu Gln Glu  Glu Glu Leu Glu Lys  Thr Val Ile 
    1295                 1300                 1305             


His Asn  Asp Asn Glu Glu Leu  Ile Lys Val Glu Gly  Thr Lys Ile 
    1310                 1315                 1320             


Val Leu  Gly Lys Gln Leu Ile  Glu Ser Ala Asp Glu  Val Arg Arg 
    1325                 1330                 1335             


Lys Ser  Leu Val Leu Lys Phe  Pro Lys Gln Gln Leu  Pro Pro Lys 
    1340                 1345                 1350             


Lys Lys  Arg Arg Val Gly Thr  Thr Val His Cys Asp  Tyr Leu Asn 
    1355                 1360                 1365             


Arg Pro  His Lys Ser Ile His  Arg Arg Arg Thr Asp  Pro Met Val 
    1370                 1375                 1380             


Thr Leu  Ser Ser Ile Leu Glu  Ser Ile Ile Asn Asp  Met Arg Asp 
    1385                 1390                 1395             


Leu Pro  Asn Thr Tyr Pro Phe  His Thr Pro Val Asn  Ala Lys Val 
    1400                 1405                 1410             


Val Lys  Asp Tyr Tyr Lys Ile  Ile Thr Arg Pro Met  Asp Leu Gln 
    1415                 1420                 1425             


Thr Leu  Arg Glu Asn Val Arg  Lys Arg Leu Tyr Pro  Ser Arg Glu 
    1430                 1435                 1440             


Glu Phe  Arg Glu His Leu Glu  Leu Ile Val Lys Asn  Ser Ala Thr 
    1445                 1450                 1455             


Tyr Asn  Gly Pro Lys His Ser  Leu Thr Gln Ile Ser  Gln Ser Met 
    1460                 1465                 1470             


Leu Asp  Leu Cys Asp Glu Lys  Leu Lys Glu Lys Glu  Asp Lys Leu 
    1475                 1480                 1485             


Ala Arg  Leu Glu Lys Ala Ile  Asn Pro Leu Leu Asp  Asp Asp Asp 
    1490                 1495                 1500             


Gln Val  Ala Phe Ser Phe Ile  Leu Asp Asn Ile Val  Thr Gln Lys 
    1505                 1510                 1515             


Met Met  Ala Val Pro Asp Ser  Trp Pro Phe His His  Pro Val Asn 
    1520                 1525                 1530             


Lys Lys  Phe Val Pro Asp Tyr  Tyr Lys Val Ile Val  Asn Pro Met 
    1535                 1540                 1545             


Asp Leu  Glu Thr Ile Arg Lys  Asn Ile Ser Lys His  Lys Tyr Gln 
    1550                 1555                 1560             


Ser Arg  Glu Ser Phe Leu Asp  Asp Val Asn Leu Ile  Leu Ala Asn 
    1565                 1570                 1575             


Ser Val  Lys Tyr Asn Gly Pro  Glu Ser Gln Tyr Thr  Lys Thr Ala 
    1580                 1585                 1590             


Gln Glu  Ile Val Asn Val Cys  Tyr Gln Thr Leu Thr  Glu Tyr Asp 
    1595                 1600                 1605             


Glu His  Leu Thr Gln Leu Glu  Lys Asp Ile Cys Thr  Ala Lys Glu 
    1610                 1615                 1620             


Ala Ala  Leu Glu Glu Ala Glu  Leu Glu Ser Leu Asp  Pro Met Thr 
    1625                 1630                 1635             


Pro Gly  Pro Tyr Thr Pro Gln  Pro Pro Asp Leu Tyr  Asp Thr Asn 
    1640                 1645                 1650             


Thr Ser  Leu Ser Met Ser Arg  Asp Ala Ser Val Phe  Gln Asp Glu 
    1655                 1660                 1665             


Ser Asn  Met Ser Val Leu Asp  Ile Pro Ser Ala Thr  Pro Glu Lys 
    1670                 1675                 1680             


Gln Val  Thr Gln Glu Gly Glu  Asp Gly Asp Gly Asp  Leu Ala Asp 
    1685                 1690                 1695             


Glu Glu  Glu Gly Thr Val Gln  Gln Pro Gln Ala Ser  Val Leu Tyr 
    1700                 1705                 1710             


Glu Asp  Leu Leu Met Ser Glu  Gly Glu Asp Asp Glu  Glu Asp Ala 
    1715                 1720                 1725             


Gly Ser  Asp Glu Glu Gly Asp  Asn Pro Phe Ser Ala  Ile Gln Leu 
    1730                 1735                 1740             


Ser Glu  Ser Gly Ser Asp Ser  Asp Val Gly Ser Gly  Gly Ile Arg 
    1745                 1750                 1755             


Pro Lys  Gln Pro Arg Met Leu  Gln Glu Asn Thr Arg  Met Asp Met 
    1760                 1765                 1770             


Glu Asn  Glu Glu Ser Met Met  Ser Tyr Glu Gly Asp  Gly Gly Glu 
    1775                 1780                 1785             


Ala Ser  His Gly Leu Glu Asp  Ser Asn Ile Ser Tyr  Gly Ser Tyr 
    1790                 1795                 1800             


Glu Glu  Pro Asp Pro Lys Ser  Asn Thr Gln Asp Thr  Ser Phe Ser 
    1805                 1810                 1815             


Ser Ile  Gly Gly Tyr Glu Val  Ser Glu Glu Glu Glu  Asp Glu Glu 
    1820                 1825                 1830             


Glu Glu  Glu Gln Arg Ser Gly  Pro Ser Val Leu Ser  Gln Val His 
    1835                 1840                 1845             


Leu Ser  Glu Asp Glu Glu Asp  Ser Glu Asp Phe His  Ser Ile Ala 
    1850                 1855                 1860             


Gly Asp  Ser Asp Leu Asp Ser  Asp Glu 
    1865                 1870         


<210>  178
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ser Lys Ser Lys Asp Asp Ala Pro His Glu Leu Glu Ser Gln Phe 
1               5                   10                  15      


Ile Leu Arg Leu Pro Pro Glu Tyr Ala Ser Thr Val Arg Arg Ala Val 
            20                  25                  30          


Gln Ser Gly His Val Asn Leu Lys Asp Arg Leu Thr Ile Glu Leu His 
        35                  40                  45              


Pro Asp Gly Arg His Gly Ile Val Arg Val Asp Arg Val Pro Leu Ala 
    50                  55                  60                  


Ser Lys Leu Val Asp Leu Pro Cys Val Met Glu Ser Leu Lys Thr Ile 
65                  70                  75                  80  


Asp Lys Lys Thr Phe Tyr Lys Thr Ala Asp Ile Cys Gln Met Leu Val 
                85                  90                  95      


Ser Thr Val Asp Gly Asp Leu Tyr Pro Pro Val Glu Glu Pro Val Ala 
            100                 105                 110         


Ser Thr Asp Pro Lys Ala Ser Lys Lys Lys Asp Lys Asp Lys Glu Lys 
        115                 120                 125             


Lys Phe Ile Trp Asn His Gly Ile Thr Leu Pro Leu Lys Asn Val Arg 
    130                 135                 140                 


Lys Arg Arg Phe Arg Lys Thr Ala Lys Lys Lys Tyr Ile Glu Ser Pro 
145                 150                 155                 160 


Asp Val Glu Lys Glu Val Lys Arg Leu Leu Ser Thr Asp Ala Glu Ala 
                165                 170                 175     


Val Ser Thr Arg Trp Glu Ile Ile Ala Glu Asp Glu Thr Lys Glu Ala 
            180                 185                 190         


Glu Asn Gln Gly Leu Asp Ile Ser Ser Pro Gly Met Ser Gly His Arg 
        195                 200                 205             


Gln Gly His Asp Ser Leu Glu His Asp Glu Leu Arg Glu Ile Phe Asn 
    210                 215                 220                 


Asp Leu Ser Ser Ser Ser Glu Asp Glu Asp Glu Thr Gln His Gln Asp 
225                 230                 235                 240 


Glu Glu Asp Ile Asn Ile Ile Asp Thr Glu Glu Asp Leu Glu Arg Gln 
                245                 250                 255     


Leu Gln Asp Lys Leu Asn Glu Ser Asp Glu Gln His Gln Glu Asn Glu 
            260                 265                 270         


Gly Thr Asn Gln Leu Val Met Gly Ile Gln Lys Gln Ile Asp Asn Met 
        275                 280                 285             


Lys Gly Lys Leu Gln Glu Thr Gln Asp Arg Ala Lys Arg Gln Glu Asp 
    290                 295                 300                 


Leu Ile Met Lys Val Glu Asn Leu Ala Leu Lys Asn Arg Phe Gln Ala 
305                 310                 315                 320 


Val Leu Asp Glu Leu Lys Gln Lys Glu Asp Arg Glu Lys Glu Gln Leu 
                325                 330                 335     


Ser Ser Leu Gln Glu Glu Leu Glu Ser Leu Leu Glu Lys 
            340                 345                 


<210>  179
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ser Cys Ser Gly Ser Gly Ala Asp Pro Glu Ala Ala Pro Ala Ser 
1               5                   10                  15      


Ala Ala Ser Ala Pro Gly Pro Ala Pro Pro Val Ser Ala Pro Ala Ala 
            20                  25                  30          


Leu Pro Ser Ser Thr Ala Ala Glu Asn Lys Ala Ser Pro Ala Gly Thr 
        35                  40                  45              


Ala Gly Gly Pro Gly Ala Gly Ala Ala Ala Gly Gly Thr Gly Pro Leu 
    50                  55                  60                  


Ala Ala Arg Ala Gly Glu Pro Ala Glu Arg Arg Gly Ala Ala Pro Val 
65                  70                  75                  80  


Ser Ala Gly Gly Ala Ala Pro Pro Glu Gly Ala Ile Ser Asn Gly Val 
                85                  90                  95      


Tyr Val Leu Pro Ser Ala Ala Asn Gly Asp Val Lys Pro Val Val Ser 
            100                 105                 110         


Ser Thr Pro Leu Val Asp Phe Leu Met Gln Leu Glu Asp Tyr Thr Pro 
        115                 120                 125             


Thr Ile Pro Asp Ala Val Thr Gly Tyr Tyr Leu Asn Arg Ala Gly Phe 
    130                 135                 140                 


Glu Ala Ser Asp Pro Arg Ile Ile Arg Leu Ile Ser Leu Ala Ala Gln 
145                 150                 155                 160 


Lys Phe Ile Ser Asp Ile Ala Asn Asp Ala Leu Gln His Cys Lys Met 
                165                 170                 175     


Lys Gly Thr Ala Ser Gly Ser Ser Arg Ser Lys Ser Lys Asp Arg Lys 
            180                 185                 190         


Tyr Thr Leu Thr Met Glu Asp Leu Thr Pro Ala Leu Ser Glu Tyr Gly 
        195                 200                 205             


Ile Asn Val Lys Lys Pro His Tyr Phe Thr 
    210                 215             


<210>  180
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Asp Asp Ala His Glu Ser Pro Ser Asp Lys Gly Gly Glu Thr Gly 
1               5                   10                  15      


Glu Ser Asp Glu Thr Ala Ala Val Pro Gly Asp Pro Gly Ala Thr Asp 
            20                  25                  30          


Thr Asp Gly Ile Pro Glu Glu Thr Asp Gly Asp Ala Asp Val Asp Leu 
        35                  40                  45              


Lys Glu Ala Ala Ala Glu Glu Gly Glu Leu Glu Ser Gln Asp Val Ser 
    50                  55                  60                  


Asp Leu Thr Thr Val Glu Arg Glu Asp Ser Ser Leu Leu Asn Pro Ala 
65                  70                  75                  80  


Ala Lys Lys Leu Lys Ile Asp Thr Lys Glu Lys Lys Glu Lys Lys Gln 
                85                  90                  95      


Lys Val Asp Glu Asp Glu Ile Gln Lys Met Gln Ile Leu Val Ser Ser 
            100                 105                 110         


Phe Ser Glu Glu Gln Leu Asn Arg Tyr Glu Met Tyr Arg Arg Ser Ala 
        115                 120                 125             


Phe Pro Lys Ala Ala Ile Lys Arg Leu Ile Gln Ser Ile Thr Gly Thr 
    130                 135                 140                 


Ser Val Ser Gln Asn Val Val Ile Ala Met Ser Gly Ile Ser Lys Val 
145                 150                 155                 160 


Phe Val Gly Glu Val Val Glu Glu Ala Leu Asp Val Cys Glu Lys Trp 
                165                 170                 175     


Gly Glu Met Pro Pro Leu Gln Pro Lys His Met Arg Glu Ala Val Arg 
            180                 185                 190         


Arg Leu Lys Ser Lys Gly Gln Ile Pro Asn Ser Lys His Lys Lys Ile 
        195                 200                 205             


Ile Phe Phe 
    210     


<210>  181
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Ala Asp Glu Glu Glu Asp Pro Thr Phe Glu Glu Glu Asn Glu Glu 
1               5                   10                  15      


Ile Gly Gly Gly Ala Glu Gly Gly Gln Gly Lys Arg Lys Arg Leu Phe 
            20                  25                  30          


Ser Lys Glu Leu Arg Cys Met Met Tyr Gly Phe Gly Asp Asp Gln Asn 
        35                  40                  45              


Pro Tyr Thr Glu Ser Val Asp Ile Leu Glu Asp Leu Val Ile Glu Phe 
    50                  55                  60                  


Ile Thr Glu Met Thr His Lys Ala Met Ser Ile Gly Arg Gln Gly Arg 
65                  70                  75                  80  


Val Gln Val Glu Asp Ile Val Phe Leu Ile Arg Lys Asp Pro Arg Lys 
                85                  90                  95      


Phe Ala Arg Val Lys Asp Leu Leu Thr Met Asn Glu Glu Leu Lys Arg 
            100                 105                 110         


Ala Arg Lys Ala Phe Asp Glu Ala Asn Tyr Gly Ser 
        115                 120                 


<210>  182
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Gly Lys Arg Asp Arg Ala Asp Arg Asp Lys Lys Lys Ser Arg Lys 
1               5                   10                  15      


Arg His Tyr Glu Asp Glu Glu Asp Asp Glu Glu Asp Ala Pro Gly Asn 
            20                  25                  30          


Asp Pro Gln Glu Ala Val Pro Ser Ala Ala Gly Lys Gln Val Asp Glu 
        35                  40                  45              


Ser Gly Thr Lys Val Asp Glu Tyr Gly Ala Lys Asp Tyr Arg Leu Gln 
    50                  55                  60                  


Met Pro Leu Lys Asp Asp His Thr Ser Arg Pro Leu Trp Val Ala Pro 
65                  70                  75                  80  


Asp Gly His Ile Phe Leu Glu Ala Phe Ser Pro Val Tyr Lys Tyr Ala 
                85                  90                  95      


Gln Asp Phe Leu Val Ala Ile Ala Glu Pro Val Cys Arg Pro Thr His 
            100                 105                 110         


Val His Glu Tyr Lys Leu Thr Ala Tyr Ser Leu Tyr Ala Ala Val Ser 
        115                 120                 125             


Val Gly Leu Gln Thr Ser Asp Ile Thr Glu Tyr Leu Arg Lys Leu Ser 
    130                 135                 140                 


Lys Thr Gly Val Pro Asp Gly Ile Met Gln Phe Ile Lys Leu Cys Thr 
145                 150                 155                 160 


Val Ser Tyr Gly Lys Val Lys Leu Val Leu Lys His Asn Arg Tyr Phe 
                165                 170                 175     


Val Glu Ser Cys His Pro Asp Val Ile Gln His Leu Leu Gln Asp Pro 
            180                 185                 190         


Val Ile Arg Glu Cys Arg Leu Arg Asn Ser Glu Gly Glu Ala Thr Glu 
        195                 200                 205             


Leu Ile Thr Glu Thr Phe Thr Ser Lys Ser Ala Ile Ser Lys Thr Ala 
    210                 215                 220                 


Glu Ser Ser Gly Gly Pro Ser Thr Ser Arg Val Thr Asp Pro Gln Gly 
225                 230                 235                 240 


Lys Ser Asp Ile Pro Met Asp Leu Phe Asp Phe Tyr Glu Gln Met Asp 
                245                 250                 255     


Lys Asp Glu Glu Glu Glu Glu Glu Thr Gln Thr Val Ser Phe Glu Val 
            260                 265                 270         


Lys Gln Glu Met Ile Glu Glu Leu Gln Lys Arg Cys Ile His Leu Glu 
        275                 280                 285             


Tyr Pro Leu Leu Ala Glu Tyr Asp Phe Arg Asn Asp Ser Val Asn Pro 
    290                 295                 300                 


Asp Ile Asn Ile Asp Leu Lys Pro Thr Ala Val Leu Arg Pro Tyr Gln 
305                 310                 315                 320 


Glu Lys Ser Leu Arg Lys Met Phe Gly Asn Gly Arg Ala Arg Ser Gly 
                325                 330                 335     


Val Ile Val Leu Pro Cys Gly Ala Gly Lys Ser Leu Val Gly Val Thr 
            340                 345                 350         


Ala Ala Cys Thr Val Arg Lys Arg Cys Leu Val Leu Gly Asn Ser Ala 
        355                 360                 365             


Val Ser Val Glu Gln Trp Lys Ala Gln Phe Lys Met Trp Ser Thr Ile 
    370                 375                 380                 


Asp Asp Ser Gln Ile Cys Arg Phe Thr Ser Asp Ala Lys Asp Lys Pro 
385                 390                 395                 400 


Ile Gly Cys Ser Val Ala Ile Ser Thr Tyr Ser Met Leu Gly His Thr 
                405                 410                 415     


Thr Lys Arg Ser Trp Glu Ala Glu Arg Val Met Glu Trp Leu Lys Thr 
            420                 425                 430         


Gln Glu Trp Gly Leu Met Ile Leu Asp Glu Val His Thr Ile Pro Ala 
        435                 440                 445             


Lys Met Phe Arg Arg Val Leu Thr Ile Val Gln Ala His Cys Lys Leu 
    450                 455                 460                 


Gly Leu Thr Ala Thr Leu Val Arg Glu Asp Asp Lys Ile Val Asp Leu 
465                 470                 475                 480 


Asn Phe Leu Ile Gly Pro Lys Leu Tyr Glu Ala Asn Trp Met Glu Leu 
                485                 490                 495     


Gln Asn Asn Gly Tyr Ile Ala Lys Val Gln Cys Ala Glu Val Trp Cys 
            500                 505                 510         


Pro Met Ser Pro Glu Phe Tyr Arg Glu Tyr Val Ala Ile Lys Thr Lys 
        515                 520                 525             


Lys Arg Ile Leu Leu Tyr Thr Met Asn Pro Asn Lys Phe Arg Ala Cys 
    530                 535                 540                 


Gln Phe Leu Ile Lys Phe His Glu Arg Arg Asn Asp Lys Ile Ile Val 
545                 550                 555                 560 


Phe Ala Asp Asn Val Phe Ala Leu Lys Glu Tyr Ala Ile Arg Leu Asn 
                565                 570                 575     


Lys Pro Tyr Ile Tyr Gly Pro Thr Ser Gln Gly Glu Arg Met Gln Ile 
            580                 585                 590         


Leu Gln Asn Phe Lys His Asn Pro Lys Ile Asn Thr Ile Phe Ile Ser 
        595                 600                 605             


Lys Val Gly Asp Thr Ser Phe Asp Leu Pro Glu Ala Asn Val Leu Ile 
    610                 615                 620                 


Gln Ile Ser Ser His Gly Gly Ser Arg Arg Gln Glu Ala Gln Arg Leu 
625                 630                 635                 640 


Gly Arg Val Leu Arg Ala Lys Lys Gly Met Val Ala Glu Glu Tyr Asn 
                645                 650                 655     


Ala Phe Phe Tyr Ser Leu Val Ser Gln Asp Thr Gln Glu Met Ala Tyr 
            660                 665                 670         


Ser Thr Lys Arg Gln Arg Phe Leu Val Asp Gln Gly Tyr Ser Phe Lys 
        675                 680                 685             


Val Ile Thr Lys Leu Ala Gly Met Glu Glu Glu Asp Leu Ala Phe Ser 
    690                 695                 700                 


Thr Lys Glu Glu Gln Gln Gln Leu Leu Gln Lys Val Leu Ala Ala Thr 
705                 710                 715                 720 


Asp Leu Asp Ala Glu Glu Glu Val Val Ala Gly Glu Phe Gly Ser Arg 
                725                 730                 735     


Ser Ser Gln Ala Ser Arg Arg Phe Gly Thr Met Ser Ser Met Ser Gly 
            740                 745                 750         


Ala Asp Asp Thr Val Tyr Met Glu Tyr His Ser Ser Arg Ser Lys Ala 
        755                 760                 765             


Pro Ser Lys His Val His Pro Leu Phe Lys Arg Phe Arg Lys 
    770                 775                 780         


<210>  183
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Asp Gln Asn Asn Ser Leu Pro Pro Tyr Ala Gln Gly Leu Ala Ser 
1               5                   10                  15      


Pro Gln Gly Ala Met Thr Pro Gly Ile Pro Ile Phe Ser Pro Met Met 
            20                  25                  30          


Pro Tyr Gly Thr Gly Leu Thr Pro Gln Pro Ile Gln Asn Thr Asn Ser 
        35                  40                  45              


Leu Ser Ile Leu Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
                85                  90                  95      


Val Ala Ala Ala Ala Val Gln Gln Ser Thr Ser Gln Gln Ala Thr Gln 
            100                 105                 110         


Gly Thr Ser Gly Gln Ala Pro Gln Leu Phe His Ser Gln Thr Leu Thr 
        115                 120                 125             


Thr Ala Pro Leu Pro Gly Thr Thr Pro Leu Tyr Pro Ser Pro Met Thr 
    130                 135                 140                 


Pro Met Thr Pro Ile Thr Pro Ala Thr Pro Ala Ser Glu Ser Ser Gly 
145                 150                 155                 160 


Ile Val Pro Gln Leu Gln Asn Ile Val Ser Thr Val Asn Leu Gly Cys 
                165                 170                 175     


Lys Leu Asp Leu Lys Thr Ile Ala Leu Arg Ala Arg Asn Ala Glu Tyr 
            180                 185                 190         


Asn Pro Lys Arg Phe Ala Ala Val Ile Met Arg Ile Arg Glu Pro Arg 
        195                 200                 205             


Thr Thr Ala Leu Ile Phe Ser Ser Gly Lys Met Val Cys Thr Gly Ala 
    210                 215                 220                 


Lys Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg Lys Tyr Ala Arg Val 
225                 230                 235                 240 


Val Gln Lys Leu Gly Phe Pro Ala Lys Phe Leu Asp Phe Lys Ile Gln 
                245                 250                 255     


Asn Met Val Gly Ser Cys Asp Val Lys Phe Pro Ile Arg Leu Glu Gly 
            260                 265                 270         


Leu Val Leu Thr His Gln Gln Phe Ser Ser Tyr Glu Pro Glu Leu Phe 
        275                 280                 285             


Pro Gly Leu Ile Tyr Arg Met Ile Lys Pro Arg Ile Val Leu Leu Ile 
    290                 295                 300                 


Phe Val Ser Gly Lys Val Val Leu Thr Gly Ala Lys Val Arg Ala Glu 
305                 310                 315                 320 


Ile Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile Leu Lys Gly Phe Arg 
                325                 330                 335     


Lys Thr Thr 
            


<210>  184
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Leu Arg Thr Ser Val Leu Arg Leu Leu Gly Arg Thr Gly Ala Ser 
1               5                   10                  15      


Arg Leu Ser Leu Leu Glu Asp Phe Gly Pro Arg Tyr Tyr Ser Ser Gly 
            20                  25                  30          


Ser Leu Ser Ala Gly Asp Asp Ala Cys Asp Val Arg Ala Tyr Phe Thr 
        35                  40                  45              


Thr Pro Ile Phe Tyr Val Asn Ala Ala Pro His Ile Gly His Leu Tyr 
    50                  55                  60                  


Ser Ala Leu Leu Ala Asp Ala Leu Cys Arg His Arg Arg Leu Arg Gly 
65                  70                  75                  80  


Pro Ser Thr Ala Ala Thr Arg Phe Ser Thr Gly Thr Asp Glu His Gly 
                85                  90                  95      


Leu Lys Ile Gln Gln Ala Ala Ala Thr Ala Gly Leu Ala Pro Thr Glu 
            100                 105                 110         


Leu Cys Asp Arg Val Ser Glu Gln Phe Gln Gln Leu Phe Gln Glu Ala 
        115                 120                 125             


Gly Ile Ser Cys Thr Asp Phe Ile Arg Thr Thr Glu Ala Arg His Arg 
    130                 135                 140                 


Val Ala Val Gln His Phe Trp Gly Val Leu Lys Ser Arg Gly Leu Leu 
145                 150                 155                 160 


Tyr Lys Gly Val Tyr Glu Gly Trp Tyr Cys Ala Ser Asp Glu Cys Phe 
                165                 170                 175     


Leu Pro Glu Ala Lys Val Thr Gln Gln Pro Gly Pro Ser Gly Asp Ser 
            180                 185                 190         


Phe Pro Val Ser Leu Glu Ser Gly His Pro Val Ser Trp Thr Lys Glu 
        195                 200                 205             


Glu Asn Tyr Ile Phe Arg Leu Ser Gln Phe Arg Lys Pro Leu Gln Arg 
    210                 215                 220                 


Trp Leu Arg Gly Asn Pro Gln Ala Ile Thr Pro Glu Pro Phe His His 
225                 230                 235                 240 


Val Val Leu Gln Trp Leu Asp Glu Glu Leu Pro Asp Leu Ser Val Ser 
                245                 250                 255     


Arg Arg Ser Ser His Leu His Trp Gly Ile Pro Val Pro Gly Asp Asp 
            260                 265                 270         


Ser Gln Thr Ile Tyr Val Trp Leu Asp Ala Leu Val Asn Tyr Leu Thr 
        275                 280                 285             


Val Ile Gly Tyr Pro Asn Ala Glu Phe Lys Ser Trp Trp Pro Ala Thr 
    290                 295                 300                 


Ser His Ile Ile Gly Lys Asp Ile Leu Lys Phe His Ala Ile Tyr Trp 
305                 310                 315                 320 


Pro Ala Phe Leu Leu Gly Ala Gly Met Ser Pro Pro Gln Arg Ile Cys 
                325                 330                 335     


Val His Ser His Trp Thr Val Cys Gly Gln Lys Met Ser Lys Ser Leu 
            340                 345                 350         


Gly Asn Val Val Asp Pro Arg Thr Cys Leu Asn Arg Tyr Thr Val Asp 
        355                 360                 365             


Gly Phe Arg Tyr Phe Leu Leu Arg Gln Gly Val Pro Asn Trp Asp Cys 
    370                 375                 380                 


Asp Tyr Tyr Asp Glu Lys Val Val Lys Leu Leu Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Asp Ala Leu Gly Gly Leu Leu Asn Arg Cys Thr Ala Lys Arg Ile Asn 
                405                 410                 415     


Pro Ser Glu Thr Tyr Pro Ala Phe Cys Thr Thr Cys Phe Pro Ser Glu 
            420                 425                 430         


Pro Gly Leu Val Gly Pro Ser Val Arg Ala Gln Ala Glu Asp Tyr Ala 
        435                 440                 445             


Leu Val Ser Ala Val Ala Thr Leu Pro Lys Gln Val Ala Asp His Tyr 
    450                 455                 460                 


Asp Asn Phe Arg Ile Tyr Lys Ala Leu Glu Ala Val Ser Ser Cys Val 
465                 470                 475                 480 


Arg Gln Thr Asn Gly Phe Val Gln Arg His Ala Pro Trp Lys Leu Asn 
                485                 490                 495     


Trp Glu Ser Pro Val Asp Ala Pro Trp Leu Gly Thr Val Leu His Val 
            500                 505                 510         


Ala Leu Glu Cys Leu Arg Val Phe Gly Thr Leu Leu Gln Pro Val Thr 
        515                 520                 525             


Pro Ser Leu Ala Asp Lys Leu Leu Ser Arg Leu Gly Val Ser Ala Ser 
    530                 535                 540                 


Glu Arg Ser Leu Gly Glu Leu Tyr Phe Leu Pro Arg Phe Tyr Gly His 
545                 550                 555                 560 


Pro Cys Pro Phe Glu Gly Arg Arg Leu Gly Pro Glu Thr Gly Leu Leu 
                565                 570                 575     


Phe Pro Arg Leu Asp Gln Ser Arg Thr Trp Leu Val Lys Ala His Arg 
            580                 585                 590         


Thr 
    


<210>  185
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Asp Val Leu Val Ser Glu Cys Ser Ala Arg Leu Leu Gln Gln Glu 
1               5                   10                  15      


Glu Glu Ile Lys Ser Leu Thr Ala Glu Ile Asp Arg Leu Lys Asn Cys 
            20                  25                  30          


Gly Cys Leu Gly Ala Ser Pro Asn Leu Glu Gln Leu Gln Glu Glu Asn 
        35                  40                  45              


Leu Lys Leu Lys Tyr Arg Leu Asn Ile Leu Arg Lys Ser Leu Gln Ala 
    50                  55                  60                  


Glu Arg Asn Lys Pro Thr Lys Asn Met Ile Asn Ile Ile Ser Arg Leu 
65                  70                  75                  80  


Gln Glu Val Phe Gly His Ala Ile Lys Ala Ala Tyr Pro Asp Leu Glu 
                85                  90                  95      


Asn Pro Pro Leu Leu Val Thr Pro Ser Gln Gln Ala Lys Phe Gly Asp 
            100                 105                 110         


Tyr Gln Cys Asn Ser Ala Met Gly Ile Ser Gln Met Leu Lys Thr Lys 
        115                 120                 125             


Glu Gln Lys Val Asn Pro Arg Glu Ile Ala Glu Asn Ile Thr Lys His 
    130                 135                 140                 


Leu Pro Asp Asn Glu Cys Ile Glu Lys Val Glu Ile Ala Gly Pro Gly 
145                 150                 155                 160 


Phe Ile Asn Val His Leu Arg Lys Asp Phe Val Ser Glu Gln Leu Thr 
                165                 170                 175     


Ser Leu Leu Val Asn Gly Val Gln Leu Pro Ala Leu Gly Glu Asn Lys 
            180                 185                 190         


Lys Val Ile Val Asp Phe Ser Ser Pro Asn Ile Ala Lys Glu Met His 
        195                 200                 205             


Val Gly His Leu Arg Ser Thr Ile Ile Gly Glu Ser Ile Ser Arg Leu 
    210                 215                 220                 


Phe Glu Phe Ala Gly Tyr Asp Val Leu Arg Leu Asn His Val Gly Asp 
225                 230                 235                 240 


Trp Gly Thr Gln Phe Gly Met Leu Ile Ala His Leu Gln Asp Lys Phe 
                245                 250                 255     


Pro Asp Tyr Leu Thr Val Ser Pro Pro Ile Gly Asp Leu Gln Val Phe 
            260                 265                 270         


Tyr Lys Glu Ser Lys Lys Arg Phe Asp Thr Glu Glu Glu Phe Lys Lys 
        275                 280                 285             


Arg Ala Tyr Gln Cys Val Val Leu Leu Gln Gly Lys Asn Pro Asp Ile 
    290                 295                 300                 


Thr Lys Ala Trp Lys Leu Ile Cys Asp Val Ser Arg Gln Glu Leu Asn 
305                 310                 315                 320 


Lys Ile Tyr Asp Ala Leu Asp Val Ser Leu Ile Glu Arg Gly Glu Ser 
                325                 330                 335     


Phe Tyr Gln Asp Arg Met Asn Asp Ile Val Lys Glu Phe Glu Asp Arg 
            340                 345                 350         


Gly Phe Val Gln Val Asp Asp Gly Arg Lys Ile Val Phe Val Pro Gly 
        355                 360                 365             


Cys Ser Ile Pro Leu Thr Ile Val Lys Ser Asp Gly Gly Tyr Thr Tyr 
    370                 375                 380                 


Asp Thr Ser Asp Leu Ala Ala Ile Lys Gln Arg Leu Phe Glu Glu Lys 
385                 390                 395                 400 


Ala Asp Met Ile Ile Tyr Val Val Asp Asn Gly Gln Ser Val His Phe 
                405                 410                 415     


Gln Thr Ile Phe Ala Ala Ala Gln Met Ile Gly Trp Tyr Asp Pro Lys 
            420                 425                 430         


Val Thr Arg Val Phe His Ala Gly Phe Gly Val Val Leu Gly Glu Asp 
        435                 440                 445             


Lys Lys Lys Phe Lys Thr Arg Ser Gly Glu Thr Val Arg Leu Met Asp 
    450                 455                 460                 


Leu Leu Gly Glu Gly Leu Lys Arg Ser Met Asp Lys Leu Lys Glu Lys 
465                 470                 475                 480 


Glu Arg Asp Lys Val Leu Thr Ala Glu Glu Leu Asn Ala Ala Gln Thr 
                485                 490                 495     


Ser Val Ala Tyr Gly Cys Ile Lys Tyr Ala Asp Leu Ser His Asn Arg 
            500                 505                 510         


Leu Asn Asp Tyr Ile Phe Ser Phe Asp Lys Met Leu Asp Asp Arg Gly 
        515                 520                 525             


Asn Thr Ala Ala Tyr Leu Leu Tyr Ala Phe Thr Arg Ile Arg Ser Ile 
    530                 535                 540                 


Ala Arg Leu Ala Asn Ile Asp Glu Glu Met Leu Gln Lys Ala Ala Arg 
545                 550                 555                 560 


Glu Thr Lys Ile Leu Leu Asp His Glu Lys Glu Trp Lys Leu Gly Arg 
                565                 570                 575     


Cys Ile Leu Arg Phe Pro Glu Ile Leu Gln Lys Ile Leu Asp Asp Leu 
            580                 585                 590         


Phe Leu His Thr Leu Cys Asp Tyr Ile Tyr Glu Leu Ala Thr Ala Phe 
        595                 600                 605             


Thr Glu Phe Tyr Asp Ser Cys Tyr Cys Val Glu Lys Asp Arg Gln Thr 
    610                 615                 620                 


Gly Lys Ile Leu Lys Val Asn Met Trp Arg Met Leu Leu Cys Glu Ala 
625                 630                 635                 640 


Val Ala Ala Val Met Ala Lys Gly Phe Asp Ile Leu Gly Ile Lys Pro 
                645                 650                 655     


Val Gln Arg Met 
            660 


<210>  186
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Trp Ser Arg Leu Val Trp Leu Gly Leu Arg Ala Pro Leu Gly Gly 
1               5                   10                  15      


Arg Gln Gly Phe Thr Ser Lys Ala Asp Pro Gln Gly Ser Gly Arg Ile 
            20                  25                  30          


Thr Ala Ala Val Ile Glu His Leu Glu Arg Leu Ala Leu Val Asp Phe 
        35                  40                  45              


Gly Ser Arg Glu Ala Val Ala Arg Leu Glu Lys Ala Ile Ala Phe Ala 
    50                  55                  60                  


Asp Arg Leu Arg Ala Val Asp Thr Asp Gly Val Glu Pro Met Glu Ser 
65                  70                  75                  80  


Val Leu Glu Asp Arg Cys Leu Tyr Leu Arg Ser Asp Asn Val Val Glu 
                85                  90                  95      


Gly Asn Cys Ala Asp Glu Leu Leu Gln Asn Ser His Arg Val Val Glu 
            100                 105                 110         


Glu Tyr Phe Val Ala Pro Pro Gly Asn Ile Ser Leu Pro Lys Leu Asp 
        115                 120                 125             


Glu Gln Glu Pro Phe Pro His Ser 
    130                 135     


<210>  187
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Leu Gly Arg Ser Leu Arg Glu Val Ser Ala Ala Leu Lys Gln Gly 
1               5                   10                  15      


Gln Ile Thr Pro Thr Glu Leu Cys Gln Lys Cys Leu Ser Leu Ile Lys 
            20                  25                  30          


Lys Thr Lys Phe Leu Asn Ala Tyr Ile Thr Val Ser Glu Glu Val Ala 
        35                  40                  45              


Leu Lys Gln Ala Glu Glu Ser Glu Lys Arg Tyr Lys Asn Gly Gln Ser 
    50                  55                  60                  


Leu Gly Asp Leu Asp Gly Ile Pro Ile Ala Val Lys Asp Asn Phe Ser 
65                  70                  75                  80  


Thr Ser Gly Ile Glu Thr Thr Cys Ala Ser Asn Met Leu Lys Gly Tyr 
                85                  90                  95      


Ile Pro Pro Tyr Asn Ala Thr Val Val Gln Lys Leu Leu Asp Gln Gly 
            100                 105                 110         


Ala Leu Leu Met Gly Lys Thr Asn Leu Asp Glu Phe Ala Met Gly Ser 
        115                 120                 125             


Gly Ser Thr Asp Gly Val Phe Gly Pro Val Lys Asn Pro Trp Ser Tyr 
    130                 135                 140                 


Ser Lys Gln Tyr Arg Glu Lys Arg Lys Gln Asn Pro His Ser Glu Asn 
145                 150                 155                 160 


Glu Asp Ser Asp Trp Leu Ile Thr Gly Gly Ser Ser Gly Gly Ser Ala 
                165                 170                 175     


Ala Ala Val Ser Ala Phe Thr Cys Tyr Ala Ala Leu Gly Ser Asp Thr 
            180                 185                 190         


Gly Gly Ser Thr Arg Asn Pro Ala Ala His Cys Gly Leu Val Gly Phe 
        195                 200                 205             


Lys Pro Ser Tyr Gly Leu Val Ser Arg His Gly Leu Ile Pro Leu Val 
    210                 215                 220                 


Asn Ser Met Asp Val Pro Gly Ile Leu Thr Arg Cys Val Asp Asp Ala 
225                 230                 235                 240 


Ala Ile Val Leu Gly Ala Leu Ala Gly Pro Asp Pro Arg Asp Ser Thr 
                245                 250                 255     


Thr Val His Glu Pro Ile Asn Lys Pro Phe Met Leu Pro Ser Leu Ala 
            260                 265                 270         


Asp Val Ser Lys Leu Cys Ile Gly Ile Pro Lys Glu Tyr Leu Val Pro 
        275                 280                 285             


Glu Leu Ser Ser Glu Val Gln Ser Leu Trp Ser Lys Ala Ala Asp Leu 
    290                 295                 300                 


Phe Glu Ser Glu Gly Ala Lys Val Ile Glu Val Ser Leu Pro His Thr 
305                 310                 315                 320 


Ser Tyr Ser Ile Val Cys Tyr His Val Leu Cys Thr Ser Glu Val Ala 
                325                 330                 335     


Ser Asn Met Ala Arg Phe Asp Gly Leu Gln Tyr Gly His Arg Cys Asp 
            340                 345                 350         


Ile Asp Val Ser Thr Glu Ala Met Tyr Ala Ala Thr Arg Arg Glu Gly 
        355                 360                 365             


Phe Asn Asp Val Val Arg Gly Arg Ile Leu Ser Gly Asn Phe Phe Leu 
    370                 375                 380                 


Leu Lys Glu Asn Tyr Glu Asn Tyr Phe Val Lys Ala Gln Lys Val Arg 
385                 390                 395                 400 


Arg Leu Ile Ala Asn Asp Phe Val Asn Ala Phe Asn Ser Gly Val Asp 
                405                 410                 415     


Val Leu Leu Thr Pro Thr Thr Leu Ser Glu Ala Val Pro Tyr Leu Glu 
            420                 425                 430         


Phe Ile Lys Glu Asp Asn Arg Thr Arg Ser Ala Gln Asp Asp Ile Phe 
        435                 440                 445             


Thr Gln Ala Val Asn Met Ala Gly Leu Pro Ala Val Ser Ile Pro Val 
    450                 455                 460                 


Ala Leu Ser Asn Gln Gly Leu Pro Ile Gly Leu Gln Phe Ile Gly Arg 
465                 470                 475                 480 


Ala Phe Cys Asp Gln Gln Leu Leu Thr Val Ala Lys Trp Phe Glu Lys 
                485                 490                 495     


Gln Val Gln Phe Pro Val Ile Gln Leu Gln Glu Leu Met Asp Asp Cys 
            500                 505                 510         


Ser Ala Val Leu Glu Asn Glu Lys Leu Ala Ser Val Ser Leu Lys Gln 
        515                 520                 525             


<210>  188
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Leu Leu Phe Cys Pro Gly Cys Gly Asn Gly Leu Ile Val Glu Glu 
1               5                   10                  15      


Gly Gln Arg Cys His Arg Phe Ser Cys Asn Thr Cys Pro Tyr Val His 
            20                  25                  30          


Asn Ile Thr Arg Lys Val Thr Asn Arg Lys Tyr Pro Lys Leu Lys Glu 
        35                  40                  45              


Val Asp Asp Val Leu Gly Gly Ala Ala Ala Trp Glu Asn Val Asp Ser 
    50                  55                  60                  


Thr Ala Glu Ser Cys Pro Lys Cys Glu His Pro Arg Ala Tyr Phe Met 
65                  70                  75                  80  


Gln Leu Gln Thr Arg Ser Ala Asp Glu Pro Met Thr Thr Phe Tyr Lys 
                85                  90                  95      


Cys Cys Asn Ala Gln Cys Gly His Arg Trp Arg Asp 
            100                 105             


<210>  189
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Ser Val Met Asp Leu Ala Asn Thr Cys Ser Ser Phe Gln Ser Asp 
1               5                   10                  15      


Leu Asp Phe Cys Ser Asp Cys Gly Ser Val Leu Pro Leu Pro Gly Ala 
            20                  25                  30          


Gln Asp Thr Val Thr Cys Ile Arg Cys Gly Phe Asn Ile Asn Val Arg 
        35                  40                  45              


Asp Phe Glu Gly Lys Val Val Lys Thr Ser Val Val Phe His Gln Leu 
    50                  55                  60                  


Gly Thr Ala Met Pro Met Ser Val Glu Glu Gly Pro Glu Cys Gln Gly 
65                  70                  75                  80  


Pro Val Val Asp Arg Arg Cys Pro Arg Cys Gly His Glu Gly Met Ala 
                85                  90                  95      


Tyr His Thr Arg Gln Met Arg Ser Ala Asp Glu Gly Gln Thr Val Phe 
            100                 105                 110         


Tyr Thr Cys Thr Asn Cys Lys Phe Gln Glu Lys Glu Asp Ser 
        115                 120                 125     


<210>  190
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Ala Cys Arg Tyr Cys Cys Ser Cys Leu Arg Leu Arg Pro Leu 
1               5                   10                  15      


Ser Asp Gly Pro Phe Leu Leu Pro Arg Arg Asp Arg Ala Leu Thr Gln 
            20                  25                  30          


Leu Gln Val Arg Ala Leu Trp Ser Ser Ala Gly Ser Arg Ala Val Ala 
        35                  40                  45              


Val Asp Leu Gly Asn Arg Lys Leu Glu Ile Ser Ser Gly Lys Leu Ala 
    50                  55                  60                  


Arg Phe Ala Asp Gly Ser Ala Val Val Gln Ser Gly Asp Thr Ala Val 
65                  70                  75                  80  


Met Val Thr Ala Val Ser Lys Thr Lys Pro Ser Pro Ser Gln Phe Met 
                85                  90                  95      


Pro Leu Val Val Asp Tyr Arg Gln Lys Ala Ala Ala Ala Gly Arg Ile 
            100                 105                 110         


Pro Thr Asn Tyr Leu Arg Arg Glu Ile Gly Thr Ser Asp Lys Glu Ile 
        115                 120                 125             


Leu Thr Ser Arg Ile Ile Asp Arg Ser Ile Arg Pro Leu Phe Pro Ala 
    130                 135                 140                 


Gly Tyr Phe Tyr Asp Thr Gln Val Leu Cys Asn Leu Leu Ala Val Asp 
145                 150                 155                 160 


Gly Val Asn Glu Pro Asp Val Leu Ala Ile Asn Gly Ala Ser Val Ala 
                165                 170                 175     


Leu Ser Leu Ser Asp Ile Pro Trp Asn Gly Pro Val Gly Ala Val Arg 
            180                 185                 190         


Ile Gly Ile Ile Asp Gly Glu Tyr Val Val Asn Pro Thr Arg Lys Glu 
        195                 200                 205             


Met Ser Ser Ser Thr Leu Asn Leu Val Val Ala Gly Ala Pro Lys Ser 
    210                 215                 220                 


Gln Ile Val Met Leu Glu Ala Ser Ala Glu Asn Ile Leu Gln Gln Asp 
225                 230                 235                 240 


Phe Cys His Ala Ile Lys Val Gly Val Lys Tyr Thr Gln Gln Ile Ile 
                245                 250                 255     


Gln Gly Ile Gln Gln Leu Val Lys Glu Thr Gly Val Thr Lys Arg Thr 
            260                 265                 270         


Pro Gln Lys Leu Phe Thr Pro Ser Pro Glu Ile Val Lys Tyr Thr His 
        275                 280                 285             


Lys Leu Ala Met Glu Arg Leu Tyr Ala Val Phe Thr Asp Tyr Glu His 
    290                 295                 300                 


Asp Lys Val Ser Arg Asp Glu Ala Val Asn Lys Ile Arg Leu Asp Thr 
305                 310                 315                 320 


Glu Glu Gln Leu Lys Glu Lys Phe Pro Glu Ala Asp Pro Tyr Glu Ile 
                325                 330                 335     


Ile Glu Ser Phe Asn Val Val Ala Lys Glu Val Phe Arg Ser Ile Val 
            340                 345                 350         


Leu Asn Glu Tyr Lys Arg Cys Asp Gly Arg Asp Leu Thr Ser Leu Arg 
        355                 360                 365             


Asn Val Ser Cys Glu Val Asp Met Phe Lys Thr Leu His Gly Ser Ala 
    370                 375                 380                 


Leu Phe Gln Arg Gly Gln Thr Gln Val Leu Cys Thr Val Thr Phe Asp 
385                 390                 395                 400 


Ser Leu Glu Ser Gly Ile Lys Ser Asp Gln Val Ile Thr Ala Ile Asn 
                405                 410                 415     


Gly Ile Lys Asp Lys Asn Phe Met Leu His Tyr Glu Phe Pro Pro Tyr 
            420                 425                 430         


Ala Thr Asn Glu Ile Gly Lys Val Thr Gly Leu Asn Arg Arg Glu Leu 
        435                 440                 445             


Gly His Gly Ala Leu Ala Glu Lys Ala Leu Tyr Pro Val Ile Pro Arg 
    450                 455                 460                 


Asp Phe Pro Phe Thr Ile Arg Val Thr Ser Glu Val Leu Glu Ser Asn 
465                 470                 475                 480 


Gly Ser Ser Ser Met Ala Ser Ala Cys Gly Gly Ser Leu Ala Leu Met 
                485                 490                 495     


Asp Ser Gly Val Pro Ile Ser Ser Ala Val Ala Gly Val Ala Ile Gly 
            500                 505                 510         


Leu Val Thr Lys Thr Asp Pro Glu Lys Gly Glu Ile Glu Asp Tyr Arg 
        515                 520                 525             


Leu Leu Thr Asp Ile Leu Gly Ile Glu Asp Tyr Asn Gly Asp Met Asp 
    530                 535                 540                 


Phe Lys Ile Ala Gly Thr Asn Lys Gly Ile Thr Ala Leu Gln Ala Asp 
545                 550                 555                 560 


Ile Lys Leu Pro Gly Ile Pro Ile Lys Ile Val Met Glu Ala Ile Gln 
                565                 570                 575     


Gln Ala Ser Val Ala Lys Lys Glu Ile Leu Gln Ile Met Asn Lys Thr 
            580                 585                 590         


Ile Ser Lys Pro Arg Ala Ser Arg Lys Glu Asn Gly Pro Val Val Glu 
        595                 600                 605             


Thr Val Gln Val Pro Leu Ser Lys Arg Ala Lys Phe Val Gly Pro Gly 
    610                 615                 620                 


Gly Tyr Asn Leu Lys Lys Leu Gln Ala Glu Thr Gly Val Thr Ile Ser 
625                 630                 635                 640 


Gln Val Asp Glu Glu Thr Phe Ser Val Phe Ala Pro Thr Pro Ser Ala 
                645                 650                 655     


Met His Glu Ala Arg Asp Phe Ile Thr Glu Ile Cys Lys Asp Asp Gln 
            660                 665                 670         


Glu Gln Gln Leu Glu Phe Gly Ala Val Tyr Thr Ala Thr Ile Thr Glu 
        675                 680                 685             


Ile Arg Asp Thr Gly Val Met Val Lys Leu Tyr Pro Asn Met Thr Ala 
    690                 695                 700                 


Val Leu Leu His Asn Thr Gln Leu Asp Gln Arg Lys Ile Lys His Pro 
705                 710                 715                 720 


Thr Ala Leu Gly Leu Glu Val Gly Gln Glu Ile Gln Val Lys Tyr Phe 
                725                 730                 735     


Gly Arg Asp Pro Ala Asp Gly Arg Met Arg Leu Ser Arg Lys Val Leu 
            740                 745                 750         


Gln Ser Pro Ala Thr Thr Val Val Arg Thr Leu Asn Asp Arg Ser Ser 
        755                 760                 765             


Ile Val Met Gly Glu Pro Ile Ser Gln Ser Ser Ser Asn Ser Gln 
    770                 775                 780             


<210>  191
<211>  1135
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Asp Pro Gly Ser Arg Trp Arg Asn Leu Pro Ser Gly Pro Ser Leu 
1               5                   10                  15      


Lys His Leu Thr Asp Pro Ser Tyr Gly Ile Pro Arg Glu Gln Gln Lys 
            20                  25                  30          


Ala Ala Leu Gln Glu Leu Thr Arg Ala His Val Glu Ser Phe Asn Tyr 
        35                  40                  45              


Ala Val His Glu Gly Leu Gly Leu Ala Val Gln Ala Ile Pro Pro Phe 
    50                  55                  60                  


Glu Phe Ala Phe Lys Asp Glu Arg Ile Ser Phe Thr Ile Leu Asp Ala 
65                  70                  75                  80  


Val Ile Ser Pro Pro Thr Val Pro Lys Gly Thr Ile Cys Lys Glu Ala 
                85                  90                  95      


Asn Val Tyr Pro Ala Glu Cys Arg Gly Arg Arg Ser Thr Tyr Arg Gly 
            100                 105                 110         


Lys Leu Thr Ala Asp Ile Asn Trp Ala Val Asn Gly Ile Ser Lys Gly 
        115                 120                 125             


Ile Ile Lys Gln Phe Leu Gly Tyr Val Pro Ile Met Val Lys Ser Lys 
    130                 135                 140                 


Leu Cys Asn Leu Arg Asn Leu Pro Pro Gln Ala Leu Ile Glu His His 
145                 150                 155                 160 


Glu Glu Ala Glu Glu Met Gly Gly Tyr Phe Ile Ile Asn Gly Ile Glu 
                165                 170                 175     


Lys Val Ile Arg Met Leu Ile Met Pro Arg Arg Asn Phe Pro Ile Ala 
            180                 185                 190         


Met Ile Arg Pro Lys Trp Lys Thr Arg Gly Pro Gly Tyr Thr Gln Tyr 
        195                 200                 205             


Gly Val Ser Met His Cys Val Arg Glu Glu His Ser Ala Val Asn Met 
    210                 215                 220                 


Asn Leu His Tyr Leu Glu Asn Gly Thr Val Met Leu Asn Phe Ile Tyr 
225                 230                 235                 240 


Arg Lys Glu Leu Phe Phe Leu Pro Leu Gly Phe Ala Leu Lys Ala Leu 
                245                 250                 255     


Val Ser Phe Ser Asp Tyr Gln Ile Phe Gln Glu Leu Ile Lys Gly Lys 
            260                 265                 270         


Glu Asp Asp Ser Phe Leu Arg Asn Ser Val Ser Gln Met Leu Arg Ile 
        275                 280                 285             


Val Met Glu Glu Gly Cys Ser Thr Gln Lys Gln Val Leu Asn Tyr Leu 
    290                 295                 300                 


Gly Glu Cys Phe Arg Val Lys Leu Asn Val Pro Asp Trp Tyr Pro Asn 
305                 310                 315                 320 


Glu Gln Ala Ala Glu Phe Leu Phe Asn Gln Cys Ile Cys Ile His Leu 
                325                 330                 335     


Lys Ser Asn Thr Glu Lys Phe Tyr Met Leu Cys Leu Met Thr Arg Lys 
            340                 345                 350         


Leu Phe Ala Leu Ala Lys Gly Glu Cys Met Glu Asp Asn Pro Asp Ser 
        355                 360                 365             


Leu Val Asn Gln Glu Val Leu Thr Pro Gly Gln Leu Phe Leu Met Phe 
    370                 375                 380                 


Leu Lys Glu Lys Leu Glu Gly Trp Leu Val Ser Ile Lys Ile Ala Phe 
385                 390                 395                 400 


Asp Lys Lys Ala Gln Lys Thr Ser Val Ser Met Asn Thr Asp Asn Leu 
                405                 410                 415     


Met Arg Ile Phe Thr Met Gly Ile Asp Leu Thr Lys Pro Phe Glu Tyr 
            420                 425                 430         


Leu Phe Ala Thr Gly Asn Leu Arg Ser Lys Thr Gly Leu Gly Leu Leu 
        435                 440                 445             


Gln Asp Ser Gly Leu Cys Val Val Ala Asp Lys Leu Asn Phe Ile Arg 
    450                 455                 460                 


Tyr Leu Ser His Phe Arg Cys Val His Arg Gly Ala Asp Phe Ala Lys 
465                 470                 475                 480 


Met Arg Thr Thr Thr Val Arg Arg Leu Leu Pro Glu Ser Trp Gly Phe 
                485                 490                 495     


Leu Cys Pro Val His Thr Pro Asp Gly Glu Pro Cys Gly Leu Met Asn 
            500                 505                 510         


His Leu Thr Ala Val Cys Glu Val Val Thr Gln Phe Val Tyr Thr Ala 
        515                 520                 525             


Ser Ile Pro Ala Leu Leu Cys Asn Leu Gly Val Thr Pro Ile Asp Gly 
    530                 535                 540                 


Ala Pro His Arg Ser Tyr Ser Glu Cys Tyr Pro Val Leu Leu Asp Gly 
545                 550                 555                 560 


Val Met Val Gly Trp Val Asp Lys Asp Leu Ala Pro Gly Ile Ala Asp 
                565                 570                 575     


Ser Leu Arg His Phe Lys Val Leu Arg Glu Lys Arg Ile Pro Pro Trp 
            580                 585                 590         


Met Glu Val Val Leu Ile Pro Met Thr Gly Lys Pro Ser Leu Tyr Pro 
        595                 600                 605             


Gly Leu Phe Leu Phe Thr Thr Pro Cys Arg Leu Val Arg Pro Val Gln 
    610                 615                 620                 


Asn Leu Ala Leu Gly Lys Glu Glu Leu Ile Gly Thr Met Glu Gln Ile 
625                 630                 635                 640 


Phe Met Asn Val Ala Ile Phe Glu Asp Glu Val Phe Ala Gly Val Thr 
                645                 650                 655     


Thr His Gln Glu Leu Phe Pro His Ser Leu Leu Ser Val Ile Ala Asn 
            660                 665                 670         


Phe Ile Pro Phe Ser Asp His Asn Gln Ser Pro Arg Asn Met Tyr Gln 
        675                 680                 685             


Cys Gln Met Gly Lys Gln Thr Met Gly Phe Pro Leu Leu Thr Tyr Gln 
    690                 695                 700                 


Asp Arg Ser Asp Asn Lys Leu Tyr Arg Leu Gln Thr Pro Gln Ser Pro 
705                 710                 715                 720 


Leu Val Arg Pro Ser Met Tyr Asp Tyr Tyr Asp Met Asp Asn Tyr Pro 
                725                 730                 735     


Ile Gly Thr Asn Ala Ile Val Ala Val Ile Ser Tyr Thr Gly Tyr Asp 
            740                 745                 750         


Met Glu Asp Ala Met Ile Val Asn Lys Ala Ser Trp Glu Arg Gly Phe 
        755                 760                 765             


Ala His Gly Ser Val Tyr Lys Ser Glu Phe Ile Asp Leu Ser Glu Lys 
    770                 775                 780                 


Ile Lys Gln Gly Asp Ser Ser Leu Val Phe Gly Ile Lys Pro Gly Asp 
785                 790                 795                 800 


Pro Arg Val Leu Gln Lys Leu Asp Asp Asp Gly Leu Pro Phe Ile Gly 
                805                 810                 815     


Ala Lys Leu Gln Tyr Gly Asp Pro Tyr Tyr Ser Tyr Leu Asn Leu Asn 
            820                 825                 830         


Thr Gly Glu Ser Phe Val Met Tyr Tyr Lys Ser Lys Glu Asn Cys Val 
        835                 840                 845             


Val Asp Asn Ile Lys Val Cys Ser Asn Asp Thr Gly Ser Gly Lys Phe 
    850                 855                 860                 


Lys Cys Val Cys Ile Thr Met Arg Val Pro Arg Asn Pro Thr Ile Gly 
865                 870                 875                 880 


Asp Lys Phe Ala Ser Arg His Gly Gln Lys Gly Ile Leu Ser Arg Leu 
                885                 890                 895     


Trp Pro Ala Glu Asp Met Pro Phe Thr Glu Ser Gly Met Val Pro Asp 
            900                 905                 910         


Ile Leu Phe Asn Pro His Gly Phe Pro Ser Arg Met Thr Ile Gly Met 
        915                 920                 925             


Leu Ile Glu Ser Met Ala Gly Lys Ser Ala Ala Leu His Gly Leu Cys 
    930                 935                 940                 


His Asp Ala Thr Pro Phe Ile Phe Ser Glu Glu Asn Ser Ala Leu Glu 
945                 950                 955                 960 


Tyr Phe Gly Glu Met Leu Lys Ala Ala Gly Tyr Asn Phe Tyr Gly Thr 
                965                 970                 975     


Glu Arg Leu Tyr Ser Gly Ile Ser Gly Leu Glu Leu Glu Ala Asp Ile 
            980                 985                 990         


Phe Ile Gly Val Val Tyr Tyr Gln  Arg Leu Arg His Met  Val Ser Asp 
        995                 1000                 1005             


Lys Phe  Gln Val Arg Thr Thr  Gly Ala Arg Asp Arg  Val Thr Asn 
    1010                 1015                 1020             


Gln Pro  Ile Gly Gly Arg Asn  Val Gln Gly Gly Ile  Arg Phe Gly 
    1025                 1030                 1035             


Glu Met  Glu Arg Asp Ala Leu  Leu Ala His Gly Thr  Ser Phe Leu 
    1040                 1045                 1050             


Leu His  Asp Arg Leu Phe Asn  Cys Ser Asp Arg Ser  Val Ala His 
    1055                 1060                 1065             


Val Cys  Val Lys Cys Gly Ser  Leu Leu Ser Pro Leu  Leu Glu Lys 
    1070                 1075                 1080             


Pro Pro  Pro Ser Trp Ser Ala  Met Arg Asn Arg Lys  Tyr Asn Cys 
    1085                 1090                 1095             


Thr Leu  Cys Ser Arg Ser Asp  Thr Ile Asp Thr Val  Ser Val Pro 
    1100                 1105                 1110             


Tyr Val  Phe Arg Tyr Phe Val  Ala Glu Leu Ala Ala  Met Asn Ile 
    1115                 1120                 1125             


Lys Val  Lys Leu Asp Val Val  
    1130                 1135 


<210>  192
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ile Cys Leu Val Leu Thr Ile Phe Ala Asn Leu Phe Pro Ala Ala 
1               5                   10                  15      


Cys Thr Gly Ala His Glu Arg Thr Phe Leu Ala Val Lys Pro Asp Gly 
            20                  25                  30          


Val Gln Arg Arg Leu Val Gly Glu Ile Val Arg Arg Phe Glu Arg Lys 
        35                  40                  45              


Gly Phe Lys Leu Val Ala Leu Lys Leu Val Gln Ala Ser Glu Glu Leu 
    50                  55                  60                  


Leu Arg Glu His Tyr Ala Glu Leu Arg Glu Arg Pro Phe Tyr Gly Arg 
65                  70                  75                  80  


Leu Val Lys Tyr Met Ala Ser Gly Pro Val Val Ala Met Val Trp Gln 
                85                  90                  95      


Gly Leu Asp Val Val Arg Thr Ser Arg Ala Leu Ile Gly Ala Thr Asn 
            100                 105                 110         


Pro Ala Asp Ala Pro Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Glu 
        115                 120                 125             


Val Gly Lys Asn Leu Ile His Gly Ser Asp Ser Val Glu Ser Ala Arg 
    130                 135                 140                 


Arg Glu Ile Ala Leu Trp Phe Arg Ala Asp Glu Leu Leu Cys Trp Glu 
145                 150                 155                 160 


Asp Ser Ala Gly His Trp Leu Tyr Glu 
                165                 


<210>  193
<211>  1107
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Asp Gly Lys Arg Arg Pro Gly Pro Gly Pro Gly Val Pro Pro Lys 
1               5                   10                  15      


Arg Ala Arg Gly Gly Leu Trp Asp Asp Asp Asp Ala Pro Arg Pro Ser 
            20                  25                  30          


Gln Phe Glu Glu Asp Leu Ala Leu Met Glu Glu Met Glu Ala Glu His 
        35                  40                  45              


Arg Leu Gln Glu Gln Glu Glu Glu Glu Leu Gln Ser Val Leu Glu Gly 
    50                  55                  60                  


Val Ala Asp Gly Gln Val Pro Pro Ser Ala Ile Asp Pro Arg Trp Leu 
65                  70                  75                  80  


Arg Pro Thr Pro Pro Ala Leu Asp Pro Gln Thr Glu Pro Leu Ile Phe 
                85                  90                  95      


Gln Gln Leu Glu Ile Asp His Tyr Val Gly Pro Ala Gln Pro Val Pro 
            100                 105                 110         


Gly Gly Pro Pro Pro Ser Arg Gly Ser Val Pro Val Leu Arg Ala Phe 
        115                 120                 125             


Gly Val Thr Asp Glu Gly Phe Ser Val Cys Cys His Ile His Gly Phe 
    130                 135                 140                 


Ala Pro Tyr Phe Tyr Thr Pro Ala Pro Pro Gly Phe Gly Pro Glu His 
145                 150                 155                 160 


Met Gly Asp Leu Gln Arg Glu Leu Asn Leu Ala Ile Ser Arg Asp Ser 
                165                 170                 175     


Arg Gly Gly Arg Glu Leu Thr Gly Pro Ala Val Leu Ala Val Glu Leu 
            180                 185                 190         


Cys Ser Arg Glu Ser Met Phe Gly Tyr His Gly His Gly Pro Ser Pro 
        195                 200                 205             


Phe Leu Arg Ile Thr Val Ala Leu Pro Arg Leu Val Ala Pro Ala Arg 
    210                 215                 220                 


Arg Leu Leu Glu Gln Gly Ile Arg Val Ala Gly Leu Gly Thr Pro Ser 
225                 230                 235                 240 


Phe Ala Pro Tyr Glu Ala Asn Val Asp Phe Glu Ile Arg Phe Met Val 
                245                 250                 255     


Asp Thr Asp Ile Val Gly Cys Asn Trp Leu Glu Leu Pro Ala Gly Lys 
            260                 265                 270         


Tyr Ala Leu Arg Leu Lys Glu Lys Ala Thr Gln Cys Gln Leu Glu Ala 
        275                 280                 285             


Asp Val Leu Trp Ser Asp Val Val Ser His Pro Pro Glu Gly Pro Trp 
    290                 295                 300                 


Gln Arg Ile Ala Pro Leu Arg Val Leu Ser Phe Asp Ile Glu Cys Ala 
305                 310                 315                 320 


Gly Arg Lys Gly Ile Phe Pro Glu Pro Glu Arg Asp Pro Val Ile Gln 
                325                 330                 335     


Ile Cys Ser Leu Gly Leu Arg Trp Gly Glu Pro Glu Pro Phe Leu Arg 
            340                 345                 350         


Leu Ala Leu Thr Leu Arg Pro Cys Ala Pro Ile Leu Gly Ala Lys Val 
        355                 360                 365             


Gln Ser Tyr Glu Lys Glu Glu Asp Leu Leu Gln Ala Trp Ser Thr Phe 
    370                 375                 380                 


Ile Arg Ile Met Asp Pro Asp Val Ile Thr Gly Tyr Asn Ile Gln Asn 
385                 390                 395                 400 


Phe Asp Leu Pro Tyr Leu Ile Ser Arg Ala Gln Thr Leu Lys Val Gln 
                405                 410                 415     


Thr Phe Pro Phe Leu Gly Arg Val Ala Gly Leu Cys Ser Asn Ile Arg 
            420                 425                 430         


Asp Ser Ser Phe Gln Ser Lys Gln Thr Gly Arg Arg Asp Thr Lys Val 
        435                 440                 445             


Val Ser Met Val Gly Arg Val Gln Met Asp Met Leu Gln Val Leu Leu 
    450                 455                 460                 


Arg Glu Tyr Lys Leu Arg Ser Tyr Thr Leu Asn Ala Val Ser Phe His 
465                 470                 475                 480 


Phe Leu Gly Glu Gln Lys Glu Asp Val Gln His Ser Ile Ile Thr Asp 
                485                 490                 495     


Leu Gln Asn Gly Asn Asp Gln Thr Arg Arg Arg Leu Ala Val Tyr Cys 
            500                 505                 510         


Leu Lys Asp Ala Tyr Leu Pro Leu Arg Leu Leu Glu Arg Leu Met Val 
        515                 520                 525             


Leu Val Asn Ala Val Glu Met Ala Arg Val Thr Gly Val Pro Leu Ser 
    530                 535                 540                 


Tyr Leu Leu Ser Arg Gly Gln Gln Val Lys Val Val Ser Gln Leu Leu 
545                 550                 555                 560 


Arg Gln Ala Met His Glu Gly Leu Leu Met Pro Val Val Lys Ser Glu 
                565                 570                 575     


Gly Gly Glu Asp Tyr Thr Gly Ala Thr Val Ile Glu Pro Leu Lys Gly 
            580                 585                 590         


Tyr Tyr Asp Val Pro Ile Ala Thr Leu Asp Phe Ser Ser Leu Tyr Pro 
        595                 600                 605             


Ser Ile Met Met Ala His Asn Leu Cys Tyr Thr Thr Leu Leu Arg Pro 
    610                 615                 620                 


Gly Thr Ala Gln Lys Leu Gly Leu Thr Glu Asp Gln Phe Ile Arg Thr 
625                 630                 635                 640 


Pro Thr Gly Asp Glu Phe Val Lys Thr Ser Val Arg Lys Gly Leu Leu 
                645                 650                 655     


Pro Gln Ile Leu Glu Asn Leu Leu Ser Ala Arg Lys Arg Ala Lys Ala 
            660                 665                 670         


Glu Leu Ala Lys Glu Thr Asp Pro Leu Arg Arg Gln Val Leu Asp Gly 
        675                 680                 685             


Arg Gln Leu Ala Leu Lys Val Ser Ala Asn Ser Val Tyr Gly Phe Thr 
    690                 695                 700                 


Gly Ala Gln Val Gly Lys Leu Pro Cys Leu Glu Ile Ser Gln Ser Val 
705                 710                 715                 720 


Thr Gly Phe Gly Arg Gln Met Ile Glu Lys Thr Lys Gln Leu Val Glu 
                725                 730                 735     


Ser Lys Tyr Thr Val Glu Asn Gly Tyr Ser Thr Ser Ala Lys Val Val 
            740                 745                 750         


Tyr Gly Asp Thr Asp Ser Val Met Cys Arg Phe Gly Val Ser Ser Val 
        755                 760                 765             


Ala Glu Ala Met Ala Leu Gly Arg Glu Ala Ala Asp Trp Val Ser Gly 
    770                 775                 780                 


His Phe Pro Ser Pro Ile Arg Leu Glu Phe Glu Lys Val Tyr Phe Pro 
785                 790                 795                 800 


Tyr Leu Leu Ile Ser Lys Lys Arg Tyr Ala Gly Leu Leu Phe Ser Ser 
                805                 810                 815     


Arg Pro Asp Ala His Asp Arg Met Asp Cys Lys Gly Leu Glu Ala Val 
            820                 825                 830         


Arg Arg Asp Asn Cys Pro Leu Val Ala Asn Leu Val Thr Ala Ser Leu 
        835                 840                 845             


Arg Arg Leu Leu Ile Asp Arg Asp Pro Glu Gly Ala Val Ala His Ala 
    850                 855                 860                 


Gln Asp Val Ile Ser Asp Leu Leu Cys Asn Arg Ile Asp Ile Ser Gln 
865                 870                 875                 880 


Leu Val Ile Thr Lys Glu Leu Thr Arg Ala Ala Ser Asp Tyr Ala Gly 
                885                 890                 895     


Lys Gln Ala His Val Glu Leu Ala Glu Arg Met Arg Lys Arg Asp Pro 
            900                 905                 910         


Gly Ser Ala Pro Ser Leu Gly Asp Arg Val Pro Tyr Val Ile Ile Ser 
        915                 920                 925             


Ala Ala Lys Gly Val Ala Ala Tyr Met Lys Ser Glu Asp Pro Leu Phe 
    930                 935                 940                 


Val Leu Glu His Ser Leu Pro Ile Asp Thr Gln Tyr Tyr Leu Glu Gln 
945                 950                 955                 960 


Gln Leu Ala Lys Pro Leu Leu Arg Ile Phe Glu Pro Ile Leu Gly Glu 
                965                 970                 975     


Gly Arg Ala Glu Ala Val Leu Leu Arg Gly Asp His Thr Arg Cys Lys 
            980                 985                 990         


Thr Val Leu Thr Gly Lys Val Gly  Gly Leu Leu Ala Phe  Ala Lys Arg 
        995                 1000                 1005             


Arg Asn  Cys Cys Ile Gly Cys  Arg Thr Val Leu Ser  His Gln Gly 
    1010                 1015                 1020             


Ala Val  Cys Glu Phe Cys Gln  Pro Arg Glu Ser Glu  Leu Tyr Gln 
    1025                 1030                 1035             


Lys Glu  Val Ser His Leu Asn  Ala Leu Glu Glu Arg  Phe Ser Arg 
    1040                 1045                 1050             


Leu Trp  Thr Gln Cys Gln Arg  Cys Gln Gly Ser Leu  His Glu Asp 
    1055                 1060                 1065             


Val Ile  Cys Thr Ser Arg Asp  Cys Pro Ile Phe Tyr  Met Arg Lys 
    1070                 1075                 1080             


Lys Val  Arg Lys Asp Leu Glu  Asp Gln Glu Gln Leu  Leu Arg Arg 
    1085                 1090                 1095             


Phe Gly  Pro Pro Gly Pro Glu  Ala Trp 
    1100                 1105         


<210>  194
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Phe Ser Glu Gln Ala Ala Gln Arg Ala His Thr Leu Leu Ser Pro 
1               5                   10                  15      


Pro Ser Ala Asn Asn Ala Thr Phe Ala Arg Val Pro Val Ala Thr Tyr 
            20                  25                  30          


Thr Asn Ser Ser Gln Pro Phe Arg Leu Gly Glu Arg Ser Phe Ser Arg 
        35                  40                  45              


Gln Tyr Ala His Ile Tyr Ala Thr Arg Leu Ile Gln Met Arg Pro Phe 
    50                  55                  60                  


Leu Glu Asn Arg Ala Gln Gln His Trp Gly Ser Gly Val Gly Val Lys 
65                  70                  75                  80  


Lys Leu Cys Glu Leu Gln Pro Glu Glu Lys Cys Cys Val Val Gly Thr 
                85                  90                  95      


Leu Phe Lys Ala Met Pro Leu Gln Pro Ser Ile Leu Arg Glu Val Ser 
            100                 105                 110         


Glu Glu His Asn Leu Leu Pro Gln Pro Pro Arg Ser Lys Tyr Ile His 
        115                 120                 125             


Pro Asp Asp Glu Leu Val Leu Glu Asp Glu Leu Gln Arg Ile Lys Leu 
    130                 135                 140                 


Lys Gly Thr Ile Asp Val Ser Lys Leu Val Thr Gly Thr Val Leu Ala 
145                 150                 155                 160 


Val Phe Gly Ser Val Arg Asp Asp Gly Lys Phe Leu Val Glu Asp Tyr 
                165                 170                 175     


Cys Phe Ala Asp Leu Ala Pro Gln Lys Pro Ala Pro Pro Leu Asp Thr 
            180                 185                 190         


Asp Arg Phe Val Leu Leu Val Ser Gly Leu Gly Leu Gly Gly Gly Gly 
        195                 200                 205             


Gly Glu Ser Leu Leu Gly Thr Gln Leu Leu Val Asp Val Val Thr Gly 
    210                 215                 220                 


Gln Leu Gly Asp Glu Gly Glu Gln Cys Ser Ala Ala His Val Ser Arg 
225                 230                 235                 240 


Val Ile Leu Ala Gly Asn Leu Leu Ser His Ser Thr Gln Ser Arg Asp 
                245                 250                 255     


Ser Ile Asn Lys Ala Lys Tyr Leu Thr Lys Lys Thr Gln Ala Ala Ser 
            260                 265                 270         


Val Glu Ala Val Lys Met Leu Asp Glu Ile Leu Leu Gln Leu Ser Ala 
        275                 280                 285             


Ser Val Pro Val Asp Val Met Pro Gly Glu Phe Asp Pro Thr Asn Tyr 
    290                 295                 300                 


Thr Leu Pro Gln Gln Pro Leu His Pro Cys Met Phe Pro Leu Ala Thr 
305                 310                 315                 320 


Ala Tyr Ser Thr Leu Gln Leu Val Thr Asn Pro Tyr Gln Ala Thr Ile 
                325                 330                 335     


Asp Gly Val Arg Phe Leu Gly Thr Ser Gly Gln Asn Val Ser Asp Ile 
            340                 345                 350         


Phe Arg Tyr Ser Ser Met Glu Asp His Leu Glu Ile Leu Glu Trp Thr 
        355                 360                 365             


Leu Arg Val Arg His Ile Ser Pro Thr Ala Pro Asp Thr Leu Gly Cys 
    370                 375                 380                 


Tyr Pro Phe Tyr Lys Thr Asp Pro Phe Ile Phe Pro Glu Cys Pro His 
385                 390                 395                 400 


Val Tyr Phe Cys Gly Asn Thr Pro Ser Phe Gly Ser Lys Ile Ile Arg 
                405                 410                 415     


Gly Pro Glu Asp Gln Thr Val Leu Leu Val Thr Val Pro Asp Phe Ser 
            420                 425                 430         


Ala Thr Gln Thr Ala Cys Leu Val Asn Leu Arg Ser Leu Ala Cys Gln 
        435                 440                 445             


Pro Ile Ser Phe Ser Gly Phe Gly Ala Glu Asp Asp Asp Leu Gly Gly 
    450                 455                 460                 


Leu Gly Leu Gly Pro 
465                 


<210>  195
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Phe Tyr His Ile Ser Leu Glu His Glu Ile Leu Leu His Pro Arg 
1               5                   10                  15      


Tyr Phe Gly Pro Asn Leu Leu Asn Thr Val Lys Gln Lys Leu Phe Thr 
            20                  25                  30          


Glu Val Glu Gly Thr Cys Thr Gly Lys Tyr Gly Phe Val Ile Ala Val 
        35                  40                  45              


Thr Thr Ile Asp Asn Ile Gly Ala Gly Val Ile Gln Pro Gly Arg Gly 
    50                  55                  60                  


Phe Val Leu Tyr Pro Val Lys Tyr Lys Ala Ile Val Phe Arg Pro Phe 
65                  70                  75                  80  


Lys Gly Glu Val Val Asp Ala Val Val Thr Gln Val Asn Lys Val Gly 
                85                  90                  95      


Leu Phe Thr Glu Ile Gly Pro Met Ser Cys Phe Ile Ser Arg His Ser 
            100                 105                 110         


Ile Pro Ser Glu Met Glu Phe Asp Pro Asn Ser Asn Pro Pro Cys Tyr 
        115                 120                 125             


Lys Thr Met Asp Glu Asp Ile Val Ile Gln Gln Asp Asp Glu Ile Arg 
    130                 135                 140                 


Leu Lys Ile Val Gly Thr Arg Val Asp Lys Asn Asp Ile Phe Ala Ile 
145                 150                 155                 160 


Gly Ser Leu Met Asp Asp Tyr Leu Gly Leu Val Ser 
                165                 170         


<210>  196
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Ala Ala Ser Gln Ala Val Glu Glu Met Arg Ser Arg Val Val Leu 
1               5                   10                  15      


Gly Glu Phe Gly Val Arg Asn Val His Thr Thr Asp Phe Pro Gly Asn 
            20                  25                  30          


Tyr Ser Gly Tyr Asp Asp Ala Trp Asp Gln Asp Arg Phe Glu Lys Asn 
        35                  40                  45              


Phe Arg Val Asp Val Val His Met Asp Glu Asn Ser Leu Glu Phe Asp 
    50                  55                  60                  


Met Val Gly Ile Asp Ala Ala Ile Ala Asn Ala Phe Arg Arg Ile Leu 
65                  70                  75                  80  


Leu Ala Glu Val Pro Thr Met Ala Val Glu Lys Val Leu Val Tyr Asn 
                85                  90                  95      


Asn Thr Ser Ile Val Gln Asp Glu Ile Leu Ala His Arg Leu Gly Leu 
            100                 105                 110         


Ile Pro Ile His Ala Asp Pro Arg Leu Phe Glu Tyr Arg Asn Gln Gly 
        115                 120                 125             


Asp Glu Glu Gly Thr Glu Ile Asp Thr Leu Gln Phe Arg Leu Gln Val 
    130                 135                 140                 


Arg Cys Thr Arg Asn Pro His Ala Ala Lys Asp Ser Ser Asp Pro Asn 
145                 150                 155                 160 


Glu Leu Tyr Val Asn His Lys Val Tyr Thr Arg His Met Thr Trp Ile 
                165                 170                 175     


Pro Leu Gly Asn Gln Ala Asp Leu Phe Pro Glu Gly Thr Ile Arg Pro 
            180                 185                 190         


Val His Asp Asp Ile Leu Ile Ala Gln Leu Arg Pro Gly Gln Glu Ile 
        195                 200                 205             


Asp Leu Leu Met His Cys Val Lys Gly Ile Gly Lys Asp His Ala Lys 
    210                 215                 220                 


Phe Ser Pro Val Ala Thr Ala Ser Tyr Arg Leu Leu Pro Asp Ile Thr 
225                 230                 235                 240 


Leu Leu Glu Pro Val Glu Gly Glu Ala Ala Glu Glu Leu Ser Arg Cys 
                245                 250                 255     


Phe Ser Pro Gly Val Ile Glu Val Gln Glu Val Gln Gly Lys Lys Val 
            260                 265                 270         


Ala Arg Val Ala Asn Pro Arg Leu Asp Thr Phe Ser Arg Glu Ile Phe 
        275                 280                 285             


Arg Asn Glu Lys Leu Lys Lys Val Val Arg Leu Ala Arg Val Arg Asp 
    290                 295                 300                 


His Tyr Ile Phe Ser Val Glu Ser Thr Gly Val Leu Pro Pro Asp Val 
305                 310                 315                 320 


Leu Val Ser Glu Ala Ile Lys Val Leu Met Gly Lys Cys Arg Arg Phe 
                325                 330                 335     


Leu Asp Glu Leu Asp Ala Val Gln Met Asp 
            340                 345     


<210>  197
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Asn Ala Pro Pro Ala Phe Glu Ser Phe Leu Leu Phe Glu Gly Glu 
1               5                   10                  15      


Lys Lys Ile Thr Ile Asn Lys Asp Thr Lys Val Pro Asn Ala Cys Leu 
            20                  25                  30          


Phe Thr Ile Asn Lys Glu Asp His Thr Leu Gly Asn Ile Ile Lys Ser 
        35                  40                  45              


Gln Leu Leu Lys Asp Pro Gln Val Leu Phe Ala Gly Tyr Lys Val Pro 
    50                  55                  60                  


His Pro Leu Glu His Lys Ile Ile Ile Arg Val Gln Thr Thr Pro Asp 
65                  70                  75                  80  


Tyr Ser Pro Gln Glu Ala Phe Thr Asn Ala Ile Thr Asp Leu Ile Ser 
                85                  90                  95      


Glu Leu Ser Leu Leu Glu Glu Arg Phe Arg Val Ala Ile Lys Asp Lys 
            100                 105                 110         


Gln Glu Gly Ile Glu 
        115         


<210>  198
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Ile Ile Pro Val Arg Cys Phe Thr Cys Gly Lys Ile Val Gly Asn 
1               5                   10                  15      


Lys Trp Glu Ala Tyr Leu Gly Leu Leu Gln Ala Glu Tyr Thr Glu Gly 
            20                  25                  30          


Asp Ala Leu Asp Ala Leu Gly Leu Lys Arg Tyr Cys Cys Arg Arg Met 
        35                  40                  45              


Leu Leu Ala His Val Asp Leu Ile Glu Lys Leu Leu Asn Tyr Ala Pro 
    50                  55                  60                  


Leu Glu Lys 
65          


<210>  199
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Thr Pro Leu Cys Pro Arg Pro Ala Leu Cys Tyr His Phe Leu Thr 
1               5                   10                  15      


Ser Leu Leu Arg Ser Ala Met Gln Asn Ala Arg Gly Ala Arg Gln Arg 
            20                  25                  30          


Ala Glu Ala Ala Val Leu Ser Gly Pro Gly Pro Pro Leu Gly Arg Ala 
        35                  40                  45              


Ala Gln His Gly Ile Pro Arg Pro Leu Ser Ser Ala Gly Arg Leu Ser 
    50                  55                  60                  


Gln Gly Cys Arg Gly Ala Ser Thr Val Gly Ala Ala Gly Trp Lys Gly 
65                  70                  75                  80  


Glu Leu Pro Lys Ala Gly Gly Ser Pro Ala Pro Gly Pro Glu Thr Pro 
                85                  90                  95      


Ala Ile Ser Pro Ser Lys Arg Ala Arg Pro Ala Glu Val Gly Gly Met 
            100                 105                 110         


Gln Leu Arg Phe Ala Arg Leu Ser Glu His Ala Thr Ala Pro Thr Arg 
        115                 120                 125             


Gly Ser Ala Arg Ala Ala Gly Tyr Asp Leu Tyr Ser Ala Tyr Asp Tyr 
    130                 135                 140                 


Thr Ile Pro Pro Met Glu Lys Ala Val Val Lys Thr Asp Ile Gln Ile 
145                 150                 155                 160 


Ala Leu Pro Ser Gly Cys Tyr Gly Arg Val Ala Pro Arg Ser Gly Leu 
                165                 170                 175     


Ala Ala Lys His Phe Ile Asp Val Gly Ala Gly Val Ile Asp Glu Asp 
            180                 185                 190         


Tyr Arg Gly Asn Val Gly Val Val Leu Phe Asn Phe Gly Lys Glu Lys 
        195                 200                 205             


Phe Glu Val Lys Lys Gly Asp Arg Ile Ala Gln Leu Ile Cys Glu Arg 
    210                 215                 220                 


Ile Phe Tyr Pro Glu Ile Glu Glu Val Gln Ala Leu Asp Asp Thr Glu 
225                 230                 235                 240 


Arg Gly Ser Gly Gly Phe Gly Ser Thr Gly Lys Asn 
                245                 250         


<210>  200
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Tyr Gln Ala Ser Ala Val Ser Leu Leu Pro Arg Asp Ile Pro Ser 
1               5                   10                  15      


Cys His Ser Pro Ser Pro Gly Phe Ser His Leu Pro Thr Ser Ser Ser 
            20                  25                  30          


Gln Leu Ala Pro Asp Leu Leu Gln Phe Pro Leu Gly Gln Asp Pro Ser 
        35                  40                  45              


Phe Leu Ala Ile Pro Ile Leu Thr Leu Pro Pro Ser Asp Ser Leu Val 
    50                  55                  60                  


Pro Pro Tyr Ile Val Trp Tyr Ile Val Trp Pro Ser Ala Leu Ile Ser 
65                  70                  75                  80  


Phe Leu Gly Cys Thr Leu Thr Val Gln Phe Ser Asn Gly Lys Leu Gln 
                85                  90                  95      


Ser Pro Gly Asn Met Arg Phe Thr Leu Tyr Glu Asn Lys Asp Ser Thr 
            100                 105                 110         


Asn Pro Arg Lys Arg Asn Gln Arg Ile Leu Ala Ala Glu Thr Asp Arg 
        115                 120                 125             


Leu Ser Tyr Val Gly Asn Asn Phe Gly Thr Gly Ala Leu Lys Cys Asn 
    130                 135                 140                 


Thr Leu Cys Arg His Phe Val Gly Ile Leu Asn Lys Thr Ser Gly Gln 
145                 150                 155                 160 


Met Glu Val Tyr Asp Ala Glu Leu Phe Asn Met Gln Pro Leu Phe Ser 
                165                 170                 175     


Asp Val Ser Val Glu Ser Glu Leu Ala Leu Glu Ser Gln Thr Lys Thr 
            180                 185                 190         


Tyr Arg Glu Lys Met Asp Ser Cys Ile Glu Ala Phe Gly Thr Thr Lys 
        195                 200                 205             


Gln Lys Arg Ala Leu Asn Thr Arg Arg Met Asn Arg Val Gly Asn Glu 
    210                 215                 220                 


Ser Leu Asn Arg Ala Val Ala Lys Ala Ala Glu Thr Ile Ile Asp Thr 
225                 230                 235                 240 


Lys Gly Val Thr Ala Leu Val Ser Asp Ala Ile His Asn Asp Leu Gln 
                245                 250                 255     


Asp Asp Ser Leu Tyr Leu Pro Pro Cys Tyr Asp Asp Ala Ala Lys Pro 
            260                 265                 270         


Glu Asp Val Tyr Lys Phe Glu Asp Leu Leu Ser Pro Ala Glu Tyr Glu 
        275                 280                 285             


Ala Leu Gln Ser Pro Ser Glu Ala Phe Arg Asn Val Thr Ser Glu Glu 
    290                 295                 300                 


Ile Leu Lys Met Ile Glu Glu Asn Ser His Cys Thr Phe Val Ile Glu 
305                 310                 315                 320 


Ala Leu Lys Ser Leu Pro Ser Asp Val Glu Ser Arg Asp Arg Gln Ala 
                325                 330                 335     


Arg Cys Ile Trp Phe Leu Asp Thr Leu Ile Lys Phe Arg Ala His Arg 
            340                 345                 350         


Val Val Lys Arg Lys Ser Ala Leu Gly Pro Gly Val Pro His Ile Ile 
        355                 360                 365             


Asn Thr Lys Leu Leu Lys His Phe Thr Cys Leu Thr Tyr Asn Asn Gly 
    370                 375                 380                 


Arg Leu Arg Asn Leu Ile Ser Asp Ser Met Lys Ala Lys Ile Thr Ala 
385                 390                 395                 400 


Tyr Val Ile Ile Leu Ala Leu His Ile His Asp Phe Gln Ile Asp Leu 
                405                 410                 415     


Thr Val Leu Gln Arg Asp Leu Lys Leu Ser Glu Lys Arg Met Met Glu 
            420                 425                 430         


Ile Ala Lys Ala Met Arg Leu Lys Ile Ser Lys Arg Arg Val Ser Val 
        435                 440                 445             


Ala Ala Gly Ser Glu Glu Asp His Lys Leu Gly Thr Leu Ser Leu Pro 
    450                 455                 460                 


Leu Pro Pro Ala Gln Thr Ser Asp Arg Leu Ala Lys Arg Arg Lys Ile 
465                 470                 475                 480 


Thr 
    


<210>  201
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Ala Asp Gln Leu Tyr Leu Glu Asn Ile Asp Glu Phe Val Thr Asp 
1               5                   10                  15      


Gln Asn Lys Ile Val Thr Tyr Lys Trp Leu Ser Tyr Thr Leu Gly Val 
            20                  25                  30          


His Val Asn Gln Ala Lys Gln Met Leu Tyr Asp Tyr Val Glu Arg Lys 
        35                  40                  45              


Arg Lys Glu Asn Ser Gly Ala Gln Leu His Val Thr Tyr Leu Val Ser 
    50                  55                  60                  


Gly Ser Leu Ile Gln Asn Gly His Ser Cys His Lys Val Ala Val Val 
65                  70                  75                  80  


Arg Glu Asp Lys Leu Glu Ala Val Lys Ser Lys Leu Ala Val Thr Ala 
                85                  90                  95      


Ser Ile His Val Tyr Ser Ile Gln Lys Ala Met Leu Lys Asp Ser Gly 
            100                 105                 110         


Pro Leu Phe Asn Thr Asp Tyr Asp Ile Leu Lys Ser Asn Leu Gln Asn 
        115                 120                 125             


Cys Ser Lys Phe Ser Ala Ile Gln Cys Ala Ala Ala Val Pro Arg Ala 
    130                 135                 140                 


Pro Ala Glu Ser Ser Ser Ser Ser Lys Lys Phe Glu Gln Ser His Leu 
145                 150                 155                 160 


His Met Ser Ser Glu Thr Gln Ala Asn Asn Glu Leu Thr Thr Asn Gly 
                165                 170                 175     


His Gly Pro Pro Ala Ser Lys Gln Val Ser Gln Gln Pro Lys Gly Ile 
            180                 185                 190         


Met Gly Met Phe Ala Ser Lys Ala Ala Ala Lys Thr Gln Glu Thr Asn 
        195                 200                 205             


Lys Glu Thr Lys Thr Glu Ala Lys Glu Val Thr Asn Ala Ser Ala Ala 
    210                 215                 220                 


Gly Asn Lys Ala Pro Gly Lys Gly Asn Met Met Ser Asn Phe Phe Gly 
225                 230                 235                 240 


Lys Ala Ala Met Asn Lys Phe Lys Val Asn Leu Asp Ser Glu Gln Ala 
                245                 250                 255     


Val Lys Glu Glu Lys Ile Val Glu Gln Pro Thr Val Ser Val Thr Glu 
            260                 265                 270         


Pro Lys Leu Ala Thr Pro Ala Gly Leu Lys Lys Ser Ser Lys Lys Ala 
        275                 280                 285             


Glu Pro Val Lys Val Leu Gln Lys Glu Lys Lys Arg Gly Lys Arg Val 
    290                 295                 300                 


Ala Leu Ser Asp Asp Glu Thr Lys Glu Thr Glu Asn Met Arg Lys Lys 
305                 310                 315                 320 


Arg Arg Arg Ile Lys Leu Pro Glu Ser Asp Ser Ser Glu Asp Glu Val 
                325                 330                 335     


Phe Pro Asp Ser Pro Gly Ala Tyr Glu Ala Glu Ser Pro Ser Pro Pro 
            340                 345                 350         


Pro Pro Pro Ser Pro Pro Leu Glu Pro Val Pro Lys Thr Glu Pro Glu 
        355                 360                 365             


Pro Pro Ser Val Lys Ser Ser Ser Gly Glu Asn Lys Arg Lys Arg Lys 
    370                 375                 380                 


Arg Val Leu Lys Ser Lys Thr Tyr Leu Asp Gly Glu Gly Cys Ile Val 
385                 390                 395                 400 


Thr Glu Lys Val Tyr Glu Ser Glu Ser Cys Thr Asp Ser Glu Glu Glu 
                405                 410                 415     


Leu Asn Met Lys Thr Ser Ser Val His Arg Pro Pro Ala Met Thr Val 
            420                 425                 430         


Lys Lys Glu Pro Arg Glu Glu Arg Lys Gly Pro Lys Lys Gly Thr Ala 
        435                 440                 445             


Ala Leu Gly Lys Ala Asn Arg Gln Val Ser Ile Thr Gly Phe Phe Gln 
    450                 455                 460                 


Arg Lys 
465     


<210>  202
<211>  711
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ala Thr Ser Ser Met Ser Lys Gly Cys Phe Val Phe Lys Pro Asn 
1               5                   10                  15      


Ser Lys Lys Arg Lys Ile Ser Leu Pro Ile Glu Asp Tyr Phe Asn Lys 
            20                  25                  30          


Gly Lys Asn Glu Pro Glu Asp Ser Lys Leu Arg Phe Glu Thr Tyr Gln 
        35                  40                  45              


Leu Ile Trp Gln Gln Met Lys Ser Glu Asn Glu Arg Leu Gln Glu Glu 
    50                  55                  60                  


Leu Asn Lys Asn Leu Phe Asp Asn Leu Ile Glu Phe Leu Gln Lys Ser 
65                  70                  75                  80  


His Ser Gly Phe Gln Lys Asn Ser Arg Asp Leu Gly Gly Gln Ile Lys 
                85                  90                  95      


Leu Arg Glu Ile Pro Thr Ala Ala Leu Val Leu Gly Val Asn Val Thr 
            100                 105                 110         


Asp His Asp Leu Thr Phe Gly Ser Leu Thr Glu Ala Leu Gln Asn Asn 
        115                 120                 125             


Val Thr Pro Tyr Val Val Ser Leu Gln Ala Lys Asp Cys Pro Asp Met 
    130                 135                 140                 


Lys His Phe Leu Gln Lys Leu Ile Ser Gln Leu Met Asp Cys Cys Val 
145                 150                 155                 160 


Asp Ile Lys Ser Lys Glu Glu Glu Ser Val His Val Thr Gln Arg Lys 
                165                 170                 175     


Thr His Tyr Ser Met Asp Ser Leu Ser Ser Trp Tyr Met Thr Val Thr 
            180                 185                 190         


Gln Lys Thr Asp Pro Lys Met Leu Ser Lys Lys Arg Thr Thr Ser Ser 
        195                 200                 205             


Gln Trp Gln Ser Pro Pro Val Val Val Ile Leu Lys Asp Met Glu Ser 
    210                 215                 220                 


Phe Ala Thr Lys Val Leu Gln Asp Phe Ile Ile Ile Ser Ser Gln His 
225                 230                 235                 240 


Leu His Glu Phe Pro Leu Ile Leu Ile Phe Gly Ile Ala Thr Ser Pro 
                245                 250                 255     


Ile Ile Ile His Arg Leu Leu Pro His Ala Val Ser Ser Leu Leu Cys 
            260                 265                 270         


Ile Glu Leu Phe Gln Ser Leu Ser Cys Lys Glu His Leu Thr Thr Val 
        275                 280                 285             


Leu Asp Lys Leu Leu Leu Thr Thr Gln Phe Pro Phe Lys Ile Asn Glu 
    290                 295                 300                 


Lys Val Leu Gln Val Leu Thr Asn Ile Phe Leu Tyr His Asp Phe Ser 
305                 310                 315                 320 


Val Gln Asn Phe Ile Lys Gly Leu Gln Leu Ser Leu Leu Glu His Phe 
                325                 330                 335     


Tyr Ser Gln Pro Leu Ser Val Leu Cys Cys Asn Leu Pro Glu Ala Lys 
            340                 345                 350         


Arg Arg Ile Asn Phe Leu Ser Asn Asn Gln Cys Glu Asn Ile Arg Arg 
        355                 360                 365             


Leu Pro Ser Phe Arg Arg Tyr Val Glu Lys Gln Ala Ser Glu Lys Gln 
    370                 375                 380                 


Val Ala Leu Leu Thr Asn Glu Arg Tyr Leu Lys Glu Glu Thr Gln Leu 
385                 390                 395                 400 


Leu Leu Glu Asn Leu His Val Tyr His Met Asn Tyr Phe Leu Val Leu 
                405                 410                 415     


Arg Cys Leu His Lys Phe Thr Ser Ser Leu Pro Lys Tyr Pro Leu Gly 
            420                 425                 430         


Arg Gln Ile Arg Glu Leu Tyr Cys Thr Cys Leu Glu Lys Asn Ile Trp 
        435                 440                 445             


Asp Ser Glu Glu Tyr Ala Ser Val Leu Gln Leu Leu Arg Met Leu Ala 
    450                 455                 460                 


Lys Asp Glu Leu Met Thr Ile Leu Glu Lys Cys Phe Lys Val Phe Lys 
465                 470                 475                 480 


Ser Tyr Cys Glu Asn His Leu Gly Ser Thr Ala Lys Arg Ile Glu Glu 
                485                 490                 495     


Phe Leu Ala Gln Phe Gln Ser Leu Asp Glu Thr Lys Glu Glu Glu Asp 
            500                 505                 510         


Ala Ser Gly Ser Gln Pro Lys Gly Leu Gln Lys Thr Asp Leu Tyr His 
        515                 520                 525             


Leu Gln Lys Ser Leu Leu Glu Met Lys Glu Leu Arg Arg Ser Lys Lys 
    530                 535                 540                 


Gln Thr Lys Phe Glu Val Leu Arg Glu Asn Val Val Asn Phe Ile Asp 
545                 550                 555                 560 


Cys Leu Val Arg Glu Tyr Leu Leu Pro Pro Glu Thr Gln Pro Leu His 
                565                 570                 575     


Glu Val Val Tyr Phe Ser Ala Ala His Ala Leu Arg Glu His Leu Asn 
            580                 585                 590         


Ala Ala Pro Arg Ile Ala Leu His Thr Ala Leu Asn Asn Pro Tyr Tyr 
        595                 600                 605             


Tyr Leu Lys Asn Glu Ala Leu Lys Ser Glu Glu Gly Cys Ile Pro Asn 
    610                 615                 620                 


Ile Ala Pro Asp Ile Cys Ile Ala Tyr Lys Leu His Leu Glu Cys Ser 
625                 630                 635                 640 


Arg Leu Ile Asn Leu Val Asp Trp Ser Glu Ala Phe Ala Thr Val Val 
                645                 650                 655     


Thr Ala Ala Glu Lys Met Asp Ala Asn Ser Ala Thr Ser Glu Glu Met 
            660                 665                 670         


Asn Glu Ile Ile His Ala Arg Phe Ile Arg Ala Val Ser Glu Leu Glu 
        675                 680                 685             


Leu Leu Gly Phe Ile Lys Pro Thr Lys Gln Lys Thr Asp His Val Ala 
    690                 695                 700                 


Arg Leu Thr Trp Gly Gly Cys 
705                 710     


<210>  203
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 
1               5                   10                  15      


Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 
            20                  25                  30          


Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 
        35                  40                  45              


Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 
    50                  55                  60                  


Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 
65                  70                  75                  80  


Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 
                85                  90                  95      


Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 
            100                 105                 110         


Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 
        115                 120                 125             


Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 
    130                 135                 140                 


Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 
145                 150                 155                 160 


Ser Gly Glu Leu Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 
                165                 170                 175     


Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 
            180                 185                 190         


Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 
        195                 200                 205             


Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 
    210                 215                 220                 


Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 
225                 230                 235                 240 


Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 
                245                 250                 255     


Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 
            260                 265                 270         


Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 
        275                 280                 285             


Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
    290                 295                 300                 


Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 
305                 310                 315                 320 


Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 
                325                 330                 335     


Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 
            340                 345                 350         


Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 
        355                 360                 365             


Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 
    370                 375                 380                 


Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 
385                 390                 395                 400 


Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 
                405                 410                 415     


Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 
            420                 425                 430         


Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 
        435                 440                 445             


Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 
    450                 455                 460                 


Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 
465                 470                 475                 480 


Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 
                485                 490                 495     


Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 
            500                 505                 510         


Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 
        515                 520                 525             


Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 
    530                 535                 540                 


Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 
545                 550                 555                 560 


Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 
                565                 570                 575     


Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 
            580                 585                 590         


Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 
        595                 600                 605             


Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 
    610                 615                 620                 


Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 
625                 630                 635                 640 


Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 
                645                 650                 655     


Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 
            660                 665                 670         


Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 
        675                 680                 685             


Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 
    690                 695                 700                 


Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 
705                 710                 715                 720 


Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 
                725                 730                 735     


Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 
            740                 745                 750         


Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 
        755                 760                 765             


Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 
    770                 775                 780                 


Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 
785                 790                 795                 800 


Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 
                805                 810                 815     


Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 
            820                 825                 830         


Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 
        835                 840                 845             


Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 
    850                 855                 860                 


Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 
865                 870                 875                 880 


Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 
                885                 890                 895     


Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 
            900                 905                 910         


Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 
        915                 920                 925             


Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 
    930                 935                 940                 


Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu 
945                 950                 955                 960 


Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu 
                965                 970                 975     


Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 
            980                 985                 990         


Ala Gln Ala Glu Glu Glu Ile Lys  Gln Glu Met Asn Thr  Leu Gln Gln 
        995                 1000                 1005             


Lys Leu  Asn Glu Gln Gln Ser  Val Leu Gln Arg Ile  Ala Ala Pro 
    1010                 1015                 1020             


Asn Met  Lys Ala Met Glu Lys  Leu Glu Ser Val Arg  Asp Lys Phe 
    1025                 1030                 1035             


Gln Glu  Thr Ser Asp Glu Phe  Glu Ala Ala Arg Lys  Arg Ala Lys 
    1040                 1045                 1050             


Lys Ala  Lys Gln Ala Phe Glu  Gln Ile Lys Lys Glu  Arg Phe Asp 
    1055                 1060                 1065             


Arg Phe  Asn Ala Cys Phe Glu  Ser Val Ala Thr Asn  Ile Asp Glu 
    1070                 1075                 1080             


Ile Tyr  Lys Ala Leu Ser Arg  Asn Ser Ser Ala Gln  Ala Phe Leu 
    1085                 1090                 1095             


Gly Pro  Glu Asn Pro Glu Glu  Pro Tyr Leu Asp Gly  Ile Asn Tyr 
    1100                 1105                 1110             


Asn Cys  Val Ala Pro Gly Lys  Arg Phe Arg Pro Met  Asp Asn Leu 
    1115                 1120                 1125             


Ser Gly  Gly Glu Lys Thr Val  Ala Ala Leu Ala Leu  Leu Phe Ala 
    1130                 1135                 1140             


Ile His  Ser Tyr Lys Pro Ala  Pro Phe Phe Val Leu  Asp Glu Ile 
    1145                 1150                 1155             


Asp Ala  Ala Leu Asp Asn Thr  Asn Ile Gly Lys Val  Ala Asn Tyr 
    1160                 1165                 1170             


Ile Lys  Glu Gln Ser Thr Cys  Asn Phe Gln Ala Ile  Val Ile Ser 
    1175                 1180                 1185             


Leu Lys  Glu Glu Phe Tyr Thr  Lys Ala Glu Ser Leu  Ile Gly Val 
    1190                 1195                 1200             


Tyr Pro  Glu Gln Gly Asp Cys  Val Ile Ser Lys Val  Leu Thr Phe 
    1205                 1210                 1215             


Asp Leu  Thr Lys Tyr Pro Asp  Ala Asn Pro Asn Pro  Asn Glu Gln 
    1220                 1225                 1230             


<210>  204
<211>  808
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Ala Gly Thr Val Val Leu Asp Asp Val Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Arg Asp Tyr Leu Asp Phe Leu Asp Asp Glu Glu Asp Gln Gly Ile Tyr 
            20                  25                  30          


Gln Ser Lys Val Arg Glu Leu Ile Ser Asp Asn Gln Tyr Arg Leu Ile 
        35                  40                  45              


Val Asn Val Asn Asp Leu Arg Arg Lys Asn Glu Lys Arg Ala Asn Arg 
    50                  55                  60                  


Leu Leu Asn Asn Ala Phe Glu Glu Leu Val Ala Phe Gln Arg Ala Leu 
65                  70                  75                  80  


Lys Asp Phe Val Ala Ser Ile Asp Ala Thr Tyr Ala Lys Gln Tyr Glu 
                85                  90                  95      


Glu Phe Tyr Val Gly Leu Glu Gly Ser Phe Gly Ser Lys His Val Ser 
            100                 105                 110         


Pro Arg Thr Leu Thr Ser Cys Phe Leu Ser Cys Val Val Cys Val Glu 
        115                 120                 125             


Gly Ile Val Thr Lys Cys Ser Leu Val Arg Pro Lys Val Val Arg Ser 
    130                 135                 140                 


Val His Tyr Cys Pro Ala Thr Lys Lys Thr Ile Glu Arg Arg Tyr Ser 
145                 150                 155                 160 


Asp Leu Thr Thr Leu Val Ala Phe Pro Ser Ser Ser Val Tyr Pro Thr 
                165                 170                 175     


Lys Asp Glu Glu Asn Asn Pro Leu Glu Thr Glu Tyr Gly Leu Ser Val 
            180                 185                 190         


Tyr Lys Asp His Gln Thr Ile Thr Ile Gln Glu Met Pro Glu Lys Ala 
        195                 200                 205             


Pro Ala Gly Gln Leu Pro Arg Ser Val Asp Val Ile Leu Asp Asp Asp 
    210                 215                 220                 


Leu Val Asp Lys Ala Lys Pro Gly Asp Arg Val Gln Val Val Gly Thr 
225                 230                 235                 240 


Tyr Arg Cys Leu Pro Gly Lys Lys Gly Gly Tyr Thr Ser Gly Thr Phe 
                245                 250                 255     


Arg Thr Val Leu Ile Ala Cys Asn Val Lys Gln Met Ser Lys Asp Ala 
            260                 265                 270         


Gln Pro Ser Phe Ser Ala Glu Asp Ile Ala Lys Ile Lys Lys Phe Ser 
        275                 280                 285             


Lys Thr Arg Ser Lys Asp Ile Phe Asp Gln Leu Ala Lys Ser Leu Ala 
    290                 295                 300                 


Pro Ser Ile His Gly His Asp Tyr Val Lys Lys Ala Ile Leu Cys Leu 
305                 310                 315                 320 


Leu Leu Gly Gly Val Glu Arg Asp Leu Glu Asn Gly Ser His Ile Arg 
                325                 330                 335     


Gly Asp Ile Asn Ile Leu Leu Ile Gly Asp Pro Ser Val Ala Lys Ser 
            340                 345                 350         


Gln Leu Leu Arg Tyr Val Leu Cys Thr Ala Pro Arg Ala Ile Pro Thr 
        355                 360                 365             


Thr Gly Arg Gly Ser Ser Gly Val Gly Leu Thr Ala Ala Val Thr Thr 
    370                 375                 380                 


Asp Gln Glu Thr Gly Glu Arg Arg Leu Glu Ala Gly Ala Met Val Leu 
385                 390                 395                 400 


Ala Asp Arg Gly Val Val Cys Ile Asp Glu Phe Asp Lys Met Ser Asp 
                405                 410                 415     


Met Asp Arg Thr Ala Ile His Glu Val Met Glu Gln Gly Arg Val Thr 
            420                 425                 430         


Ile Ala Lys Ala Gly Ile His Ala Arg Leu Asn Ala Arg Cys Ser Val 
        435                 440                 445             


Leu Ala Ala Ala Asn Pro Val Tyr Gly Arg Tyr Asp Gln Tyr Lys Thr 
    450                 455                 460                 


Pro Met Glu Asn Ile Gly Leu Gln Asp Ser Leu Leu Ser Arg Phe Asp 
465                 470                 475                 480 


Leu Leu Phe Ile Met Leu Asp Gln Met Asp Pro Glu Gln Asp Arg Glu 
                485                 490                 495     


Ile Ser Asp His Val Leu Arg Met His Arg Tyr Arg Ala Pro Gly Glu 
            500                 505                 510         


Gln Asp Gly Asp Ala Met Pro Leu Gly Ser Ala Val Asp Ile Leu Ala 
        515                 520                 525             


Thr Asp Asp Pro Asn Phe Ser Gln Glu Asp Gln Gln Asp Thr Gln Ile 
    530                 535                 540                 


Tyr Glu Lys His Asp Asn Leu Leu His Gly Thr Lys Lys Lys Lys Glu 
545                 550                 555                 560 


Lys Met Val Ser Ala Ala Phe Met Lys Lys Tyr Ile His Val Ala Lys 
                565                 570                 575     


Ile Ile Lys Pro Val Leu Thr Gln Glu Ser Ala Thr Tyr Ile Ala Glu 
            580                 585                 590         


Glu Tyr Ser Arg Leu Arg Ser Gln Asp Ser Met Ser Ser Asp Thr Ala 
        595                 600                 605             


Arg Thr Ser Pro Val Thr Ala Arg Thr Leu Glu Thr Leu Ile Arg Leu 
    610                 615                 620                 


Ala Thr Ala His Ala Lys Ala Arg Met Ser Lys Thr Val Asp Leu Gln 
625                 630                 635                 640 


Asp Ala Glu Glu Ala Val Glu Leu Val Gln Tyr Ala Tyr Phe Lys Lys 
                645                 650                 655     


Val Leu Glu Lys Glu Lys Lys Arg Lys Lys Arg Ser Glu Asp Glu Ser 
            660                 665                 670         


Glu Thr Glu Asp Glu Glu Glu Lys Ser Gln Glu Asp Gln Glu Gln Lys 
        675                 680                 685             


Arg Lys Arg Arg Lys Thr Arg Gln Pro Asp Ala Lys Asp Gly Asp Ser 
    690                 695                 700                 


Tyr Asp Pro Tyr Asp Phe Ser Asp Thr Glu Glu Glu Met Pro Gln Val 
705                 710                 715                 720 


His Thr Pro Lys Thr Ala Asp Ser Gln Glu Thr Lys Glu Ser Gln Lys 
                725                 730                 735     


Val Glu Leu Ser Glu Ser Arg Leu Lys Ala Phe Lys Val Ala Leu Leu 
            740                 745                 750         


Asp Val Phe Arg Glu Ala His Ala Gln Ser Ile Gly Met Asn Arg Leu 
        755                 760                 765             


Thr Glu Ser Ile Asn Arg Asp Ser Glu Glu Pro Phe Ser Ser Val Glu 
    770                 775                 780                 


Ile Gln Ala Ala Leu Ser Lys Met Gln Asp Asp Asn Gln Val Met Val 
785                 790                 795                 800 


Ser Glu Gly Ile Ile Phe Leu Ile 
                805             


<210>  205
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Asp Leu Ala Ala Ala Ala Glu Pro Gly Ala Gly Ser Gln His Leu 
1               5                   10                  15      


Glu Val Arg Asp Glu Val Ala Glu Lys Cys Gln Lys Leu Phe Leu Asp 
            20                  25                  30          


Phe Leu Glu Glu Phe Gln Ser Ser Asp Gly Glu Ile Lys Tyr Leu Gln 
        35                  40                  45              


Leu Ala Glu Glu Leu Ile Arg Pro Glu Arg Asn Thr Leu Val Val Ser 
    50                  55                  60                  


Phe Val Asp Leu Glu Gln Phe Asn Gln Gln Leu Ser Thr Thr Ile Gln 
65                  70                  75                  80  


Glu Glu Phe Tyr Arg Val Tyr Pro Tyr Leu Cys Arg Ala Leu Lys Thr 
                85                  90                  95      


Phe Val Lys Asp Arg Lys Glu Ile Pro Leu Ala Lys Asp Phe Tyr Val 
            100                 105                 110         


Ala Phe Gln Asp Leu Pro Thr Arg His Lys Ile Arg Glu Leu Thr Ser 
        115                 120                 125             


Ser Arg Ile Gly Leu Leu Thr Arg Ile Ser Gly Gln Val Val Arg Thr 
    130                 135                 140                 


His Pro Val His Pro Glu Leu Val Ser Gly Thr Phe Leu Cys Leu Asp 
145                 150                 155                 160 


Cys Gln Thr Val Ile Arg Asp Val Glu Gln Gln Phe Lys Tyr Thr Gln 
                165                 170                 175     


Pro Asn Ile Cys Arg Asn Pro Val Cys Ala Asn Arg Arg Arg Phe Leu 
            180                 185                 190         


Leu Asp Thr Asn Lys Ser Arg Phe Val Asp Phe Gln Lys Val Arg Ile 
        195                 200                 205             


Gln Glu Thr Gln Ala Glu Leu Pro Arg Gly Ser Ile Pro Arg Ser Leu 
    210                 215                 220                 


Glu Val Ile Leu Arg Ala Glu Ala Val Glu Ser Ala Gln Ala Gly Asp 
225                 230                 235                 240 


Lys Cys Asp Phe Thr Gly Thr Leu Ile Val Val Pro Asp Val Ser Lys 
                245                 250                 255     


Leu Ser Thr Pro Gly Ala Arg Ala Glu Thr Asn Ser Arg Val Ser Gly 
            260                 265                 270         


Val Asp Gly Tyr Glu Thr Glu Gly Ile Arg Gly Leu Arg Ala Leu Gly 
        275                 280                 285             


Val Arg Asp Leu Ser Tyr Arg Leu Val Phe Leu Ala Cys Cys Val Ala 
    290                 295                 300                 


Pro Thr Asn Pro Arg Phe Gly Gly Lys Glu Leu Arg Asp Glu Glu Gln 
305                 310                 315                 320 


Thr Ala Glu Ser Ile Lys Asn Gln Met Thr Val Lys Glu Trp Glu Lys 
                325                 330                 335     


Val Phe Glu Met Ser Gln Asp Lys Asn Leu Tyr His Asn Leu Cys Thr 
            340                 345                 350         


Ser Leu Phe Pro Thr Ile His Gly Asn Asp Glu Val Lys Arg Gly Val 
        355                 360                 365             


Leu Leu Met Leu Phe Gly Gly Val Pro Lys Thr Thr Gly Glu Gly Thr 
    370                 375                 380                 


Ser Leu Arg Gly Asp Ile Asn Val Cys Ile Val Gly Asp Pro Ser Thr 
385                 390                 395                 400 


Ala Lys Ser Gln Phe Leu Lys His Val Glu Glu Phe Ser Pro Arg Ala 
                405                 410                 415     


Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala Ala Gly Leu Thr Ala Ala 
            420                 425                 430         


Val Val Arg Asp Glu Glu Ser His Glu Phe Val Ile Glu Ala Gly Ala 
        435                 440                 445             


Leu Met Leu Ala Asp Asn Gly Val Cys Cys Ile Asp Glu Phe Asp Lys 
    450                 455                 460                 


Met Asp Val Arg Asp Gln Val Ala Ile His Glu Ala Met Glu Gln Gln 
465                 470                 475                 480 


Thr Ile Ser Ile Thr Lys Ala Gly Val Lys Ala Thr Leu Asn Ala Arg 
                485                 490                 495     


Thr Ser Ile Leu Ala Ala Ala Asn Pro Ile Ser Gly His Tyr Asp Arg 
            500                 505                 510         


Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu Ser Ala Pro Ile Met Ser 
        515                 520                 525             


Arg Phe Asp Leu Phe Phe Ile Leu Val Asp Glu Cys Asn Glu Val Thr 
    530                 535                 540                 


Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp Leu His Ser Arg Ile Glu 
545                 550                 555                 560 


Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp Asp Ile Arg Arg Tyr Leu 
                565                 570                 575     


Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile Ser Lys Glu Ser Glu Asp 
            580                 585                 590         


Phe Ile Val Glu Gln Tyr Lys His Leu Arg Gln Arg Asp Gly Ser Gly 
        595                 600                 605             


Val Thr Lys Ser Ser Trp Arg Ile Thr Val Arg Gln Leu Glu Ser Met 
    610                 615                 620                 


Ile Arg Leu Ser Glu Ala Met Ala Arg Met His Cys Cys Asp Glu Val 
625                 630                 635                 640 


Gln Pro Lys His Val Lys Glu Ala Phe Arg Leu Leu Asn Lys Ser Ile 
                645                 650                 655     


Ile Arg Val Glu Thr Pro Asp Val Asn Leu Asp Gln Glu Glu Glu Ile 
            660                 665                 670         


Gln Met Glu Val Asp Glu Gly Ala Gly Gly Ile Asn Gly His Ala Asp 
        675                 680                 685             


Ser Pro Ala Pro Val Asn Gly Ile Asn Gly Tyr Asn Glu Asp Ile Asn 
    690                 695                 700                 


Gln Glu Ser Ala Pro Lys Ala Ser Leu Arg Leu Gly Phe Ser Glu Tyr 
705                 710                 715                 720 


Cys Arg Ile Ser Asn Leu Ile Val Leu His Leu Arg Lys Val Glu Glu 
                725                 730                 735     


Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser Glu Leu Val Asn Trp Tyr 
            740                 745                 750         


Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser Glu Glu Glu Leu Ile Asn 
        755                 760                 765             


Lys Lys Arg Ile Ile Glu Lys Val Ile His Arg Leu Thr His Tyr Asp 
    770                 775                 780                 


His Val Leu Ile Glu Leu Thr Gln Ala Gly Leu Lys Gly Ser Thr Glu 
785                 790                 795                 800 


Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr Leu Val Val Asn Pro Asn 
                805                 810                 815     


Tyr Leu Leu Glu Asp 
            820     


<210>  206
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Phe Val Ser Asp Phe Arg Lys Glu Phe Tyr Glu Val Val Gln Ser 
1               5                   10                  15      


Gln Arg Val Leu Leu Phe Val Ala Ser Asp Val Asp Ala Leu Cys Ala 
            20                  25                  30          


Cys Lys Ile Leu Gln Ala Leu Phe Gln Cys Asp His Val Gln Tyr Thr 
        35                  40                  45              


Leu Val Pro Val Ser Gly Trp Gln Glu Leu Glu Thr Ala Phe Leu Glu 
    50                  55                  60                  


His Lys Glu Gln Phe His Tyr Phe Ile Leu Ile Asn Cys Gly Ala Asn 
65                  70                  75                  80  


Val Asp Leu Leu Asp Ile Leu Gln Pro Asp Glu Asp Thr Ile Phe Phe 
                85                  90                  95      


Val Cys Asp Thr His Arg Pro Val Asn Val Val Asn Val Tyr Asn Asp 
            100                 105                 110         


Thr Gln Ile Lys Leu Leu Ile Lys Gln Asp Asp Asp Leu Glu Val Pro 
        115                 120                 125             


Ala Tyr Glu Asp Ile Phe Arg Asp Glu Glu Glu Asp Glu Glu His Ser 
    130                 135                 140                 


Gly Asn Asp Ser Asp Gly Ser Glu Pro Ser Glu Lys Arg Thr Arg Leu 
145                 150                 155                 160 


Glu Glu Glu Ile Val Glu Gln Thr Met Arg Arg Arg Gln Arg Arg Glu 
                165                 170                 175     


Trp Glu Ala Arg Arg Arg Asp Ile Leu Phe Asp Tyr Glu Gln Tyr Glu 
            180                 185                 190         


Tyr His Gly Thr Ser Ser Ala Met Val Met Phe Glu Leu Ala Trp Met 
        195                 200                 205             


Leu Ser Lys Asp Leu Asn Asp Met Leu Trp Trp Ala Ile Val Gly Leu 
    210                 215                 220                 


Thr Asp Gln Trp Val Gln Asp Lys Ile Thr Gln Met Lys Tyr Val Thr 
225                 230                 235                 240 


Asp Val Gly Val Leu Gln Arg His Val Ser Arg His Asn His Arg Asn 
                245                 250                 255     


Glu Asp Glu Glu Asn Thr Leu Ser Val Asp Cys Thr Arg Ile Ser Phe 
            260                 265                 270         


Glu Tyr Asp Leu Arg Leu Val Leu Tyr Gln His Trp Ser Leu His Asp 
        275                 280                 285             


Ser Leu Cys Asn Thr Ser Tyr Thr Ala Ala Arg Phe Lys Leu Trp Ser 
    290                 295                 300                 


Val His Gly Gln Lys Arg Leu Gln Glu Phe Leu Ala Asp Met Gly Leu 
305                 310                 315                 320 


Pro Leu Lys Gln Val Lys Gln Lys Phe Gln Ala Met Asp Ile Ser Leu 
                325                 330                 335     


Lys Glu Asn Leu Arg Glu Met Ile Glu Glu Ser Ala Asn Lys Phe Gly 
            340                 345                 350         


Met Lys Asp Met Arg Val Gln Thr Phe Ser Ile His Phe Gly Phe Lys 
        355                 360                 365             


His Lys Phe Leu Ala Ser Asp Val Val Phe Ala Thr Met Ser Leu Met 
    370                 375                 380                 


Glu Ser Pro Glu Lys Asp Gly Ser Gly Thr Asp His Phe Ile Gln Ala 
385                 390                 395                 400 


Leu Asp Ser Leu Ser Arg Ser Asn Leu Asp Lys Leu Tyr His Gly Leu 
                405                 410                 415     


Glu Leu Ala Lys Lys Gln Leu Arg Ala Thr Gln Gln Thr Ile Ala Ser 
            420                 425                 430         


Cys Leu Cys Thr Asn Leu Val Ile Ser Gln Gly Pro Phe Leu Tyr Cys 
        435                 440                 445             


Ser Leu Met Glu Gly Thr Pro Asp Val Met Leu Phe Ser Arg Pro Ala 
    450                 455                 460                 


Ser Leu Ser Leu Leu Ser Lys His Leu Leu Lys Ser Phe Val Cys Ser 
465                 470                 475                 480 


Thr Lys Asn Arg Arg Cys Lys Leu Leu Pro Leu Val Met Ala Ala Pro 
                485                 490                 495     


Leu Ser Met Glu His Gly Thr Val Thr Val Val Gly Ile Pro Pro Glu 
            500                 505                 510         


Thr Asp Ser Ser Asp Arg Lys Asn Phe Phe Gly Arg Ala Phe Glu Lys 
        515                 520                 525             


Ala Ala Glu Ser Thr Ser Ser Arg Met Leu His Asn His Phe Asp Leu 
    530                 535                 540                 


Ser Val Ile Glu Leu Lys Ala Glu Asp Arg Ser Lys Phe Leu Asp Ala 
545                 550                 555                 560 


Leu Ile Ser Leu Leu Ser 
                565     


<210>  207
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Thr Thr Pro Asn Lys Thr Pro Pro Gly Ala Asp Pro Lys Gln Leu 
1               5                   10                  15      


Glu Arg Thr Gly Thr Val Arg Glu Ile Gly Ser Gln Ala Val Trp Ser 
            20                  25                  30          


Leu Ser Ser Cys Lys Pro Gly Phe Gly Val Asp Gln Leu Arg Asp Asp 
        35                  40                  45              


Asn Leu Glu Thr Tyr Trp Gln Ser Asp Gly Ser Gln Pro His Leu Val 
    50                  55                  60                  


Asn Ile Gln Phe Arg Arg Lys Thr Thr Val Lys Thr Leu Cys Ile Tyr 
65                  70                  75                  80  


Ala Asp Tyr Lys Ser Asp Glu Ser Tyr Thr Pro Ser Lys Ile Ser Val 
                85                  90                  95      


Arg Val Gly Asn Asn Phe His Asn Leu Gln Glu Ile Arg Gln Leu Glu 
            100                 105                 110         


Leu Val Glu Pro Ser Gly Trp Ile His Val Pro Leu Thr Asp Asn His 
        115                 120                 125             


Lys Lys Pro Thr Arg Thr Phe Met Ile Gln Ile Ala Val Leu Ala Asn 
    130                 135                 140                 


His Gln Asn Gly Arg Asp Thr His Met Arg Gln Ile Lys Ile Tyr Thr 
145                 150                 155                 160 


Pro Val Glu Glu Ser Ser Ile Gly Lys Phe Pro Arg Cys Thr Thr Ile 
                165                 170                 175     


Asp Phe Met Met Tyr Arg Ser Ile Arg 
            180                 185 


<210>  208
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Thr Leu Glu Glu Val Arg Gly Gln Asp Thr Val Pro Glu Ser Thr 
1               5                   10                  15      


Ala Arg Met Gln Gly Ala Gly Lys Ala Leu His Glu Leu Leu Leu Ser 
            20                  25                  30          


Ala Gln Arg Gln Gly Cys Leu Thr Ala Gly Val Tyr Glu Ser Ala Lys 
        35                  40                  45              


Val Leu Asn Val Asp Pro Asp Asn Val Thr Phe Cys Val Leu Ala Ala 
    50                  55                  60                  


Gly Glu Glu Asp Glu Gly Asp Ile Ala Leu Gln Ile His Phe Thr Leu 
65                  70                  75                  80  


Ile Gln Ala Phe Cys Cys Glu Asn Asp Ile Asp Ile Val Arg Val Gly 
                85                  90                  95      


Asp Val Gln Arg Leu Ala Ala Ile Val Gly Ala Gly Glu Glu Ala Gly 
            100                 105                 110         


Ala Pro Gly Asp Leu His Cys Ile Leu Ile Ser Asn Pro Asn Glu Asp 
        115                 120                 125             


Ala Trp Lys Asp Pro Ala Leu Glu Lys Leu Ser Leu Phe Cys Glu Glu 
    130                 135                 140                 


Ser Arg Ser Val Asn Asp Trp Val Pro Ser Ile Thr Leu Pro Glu 
145                 150                 155                 


<210>  209
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Phe Tyr Ala His Phe Val Leu Ser Lys Arg Gly Pro Leu Ala Lys 
1               5                   10                  15      


Ile Trp Leu Ala Ala His Trp Asp Lys Lys Leu Thr Lys Ala His Val 
            20                  25                  30          


Phe Glu Cys Asn Leu Glu Ser Ser Val Glu Ser Ile Ile Ser Pro Lys 
        35                  40                  45              


Val Lys Met Ala Leu Arg Thr Ser Gly His Leu Leu Leu Gly Val Val 
    50                  55                  60                  


Arg Ile Tyr His Arg Lys Ala Lys Tyr Leu Leu Ala Asp Cys Asn Glu 
65                  70                  75                  80  


Ala Phe Ile Lys Ile Lys Met Ala Phe Arg Pro Gly Val Val Asp Leu 
                85                  90                  95      


Pro Glu Glu Asn Arg Glu Ala Ala Tyr Asn Ala Ile Thr Leu Pro Glu 
            100                 105                 110         


Glu Phe His Asp Phe Asp Gln Pro Leu Pro Asp Leu Asp Asp Ile Asp 
        115                 120                 125             


Val Ala Gln Gln Phe Ser Leu Asn Gln Ser Arg Val Glu Glu Ile Thr 
    130                 135                 140                 


Met Arg Glu Glu Val Gly Asn Ile Ser Ile Leu Gln Glu Asn Asp Phe 
145                 150                 155                 160 


Gly Asp Phe Gly Met Asp Asp Arg Glu Ile Met Arg Glu Gly Ser Ala 
                165                 170                 175     


Phe Glu Asp Asp Asp Met Leu Val Ser Thr Thr Thr Ser Asn Leu Leu 
            180                 185                 190         


Leu Glu Ser Glu Gln Ser Thr Ser Asn Leu Asn Glu Lys Ile Asn His 
        195                 200                 205             


Leu Glu Tyr Glu Asp Gln Tyr Lys Asp Asp Asn Phe Gly Glu Gly Asn 
    210                 215                 220                 


Asp Gly Gly Ile Leu Asp Asp Lys Leu Ile Ser Asn Asn Asp Gly Gly 
225                 230                 235                 240 


Ile Phe Asp Asp Pro Pro Ala Leu Ser Glu Ala Gly Val Met Leu Pro 
                245                 250                 255     


Glu Gln Pro Ala His Asp Asp Met Asp Glu Asp Asp Asn Val Ser Met 
            260                 265                 270         


Gly Gly Pro Asp Ser Pro Asp Ser Val Asp Pro Val Glu Pro Met Pro 
        275                 280                 285             


Thr Met Thr Asp Gln Thr Thr Leu Val Pro Asn Glu Glu Glu Ala Phe 
    290                 295                 300                 


Ala Leu Glu Pro Ile Asp Ile Thr Val Lys Glu Thr Lys Ala Lys Arg 
305                 310                 315                 320 


Lys Arg Lys Leu Ile Val Asp Ser Val Lys Glu Leu Asp Ser Lys Thr 
                325                 330                 335     


Ile Arg Ala Gln Leu Ser Asp Tyr Ser Asp Ile Val Thr Thr Leu Asp 
            340                 345                 350         


Leu Ala Pro Pro Thr Lys Lys Leu Met Met Trp Lys Glu Thr Gly Gly 
        355                 360                 365             


Val Glu Lys Leu Phe Ser Leu Pro Ala Gln Pro Leu Trp Asn Asn Arg 
    370                 375                 380                 


Leu Leu Lys Leu Phe Thr Arg Cys Leu Thr Pro Leu Val Pro Glu Asp 
385                 390                 395                 400 


Leu Arg Lys Arg Arg Lys Gly Gly Glu Ala Asp Asn Leu Asp Glu Phe 
                405                 410                 415     


Leu Lys Glu Phe Glu Asn Pro Glu Val Pro Arg Glu Asp Gln Gln Gln 
            420                 425                 430         


Gln His Gln Gln Arg Asp Val Ile Asp Glu Pro Ile Ile Glu Glu Pro 
        435                 440                 445             


Ser Arg Leu Gln Glu Ser Val Met Glu Ala Ser Arg Thr Asn Ile Asp 
    450                 455                 460                 


Glu Ser Ala Met Pro Pro Pro Pro Pro Gln Gly Val Lys Arg Lys Ala 
465                 470                 475                 480 


Gly Gln Ile Asp Pro Glu Pro Val Met Pro Pro Gln Gln Val Glu Gln 
                485                 490                 495     


Met Glu Ile Pro Pro Val Glu Leu Pro Pro Glu Glu Pro Pro Asn Ile 
            500                 505                 510         


Cys Gln Leu Ile Pro Glu Leu Glu Leu Leu Pro Glu Lys Glu Lys Glu 
        515                 520                 525             


Lys Glu Lys Glu Lys Glu Asp Asp Glu Glu Glu Glu Asp Glu Asp Ala 
    530                 535                 540                 


Ser Gly Gly Asp Gln Asp Gln Glu Glu Arg Arg Trp Asn Lys Arg Thr 
545                 550                 555                 560 


Gln Gln Met Leu His Gly Leu Gln Arg Ala Leu Ala Lys Thr Gly Ala 
                565                 570                 575     


Glu Ser Ile Ser Leu Leu Glu Leu Cys Arg Asn Thr Asn Arg Lys Gln 
            580                 585                 590         


Ala Ala Ala Lys Phe Tyr Ser Phe Leu Val Leu Lys Lys Gln Gln Ala 
        595                 600                 605             


Ile Glu Leu Thr Gln Glu Glu Pro Tyr Ser Asp Ile Ile Ala Thr Pro 
    610                 615                 620                 


Gly Pro Arg Phe His Ile Ile 
625                 630     


<210>  210
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Leu Gln Gly Pro Arg Ala Leu Ala Ser Ala Ala Gly Gln Thr Pro 
1               5                   10                  15      


Lys Val Val Pro Ala Met Ser Pro Thr Glu Leu Trp Pro Ser Gly Leu 
            20                  25                  30          


Ser Ser Pro Gln Leu Cys Pro Ala Thr Ala Thr Tyr Tyr Thr Pro Leu 
        35                  40                  45              


Tyr Pro Gln Thr Ala Pro Pro Ala Ala Ala Pro Gly Thr Cys Leu Asp 
    50                  55                  60                  


Ala Thr Pro His Gly Pro Glu Gly Gln Val Val Arg Cys Leu Pro Ala 
65                  70                  75                  80  


Gly Arg Leu Pro Ala Lys Arg Lys Leu Asp Leu Glu Gly Ile Gly Arg 
                85                  90                  95      


Pro Val Val Pro Glu Phe Pro Thr Pro Lys Gly Lys Cys Ile Arg Val 
            100                 105                 110         


Asp Gly Leu Pro Ser Pro Lys Thr Pro Lys Ser Pro Gly Glu Lys Thr 
        115                 120                 125             


Arg Tyr Asp Thr Ser Leu Gly Leu Leu Thr Lys Lys Phe Ile Tyr Leu 
    130                 135                 140                 


Leu Ser Glu Ser Glu Asp Gly Val Leu Asp Leu Asn Trp Ala Ala Glu 
145                 150                 155                 160 


Val Leu Asp Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val Leu 
                165                 170                 175     


Glu Gly Ile Gln Leu Ile Arg Lys Lys Ala Lys Asn Asn Ile Gln Trp 
            180                 185                 190         


Val Gly Arg Gly Met Phe Glu Asp Pro Thr Arg Pro Gly Lys Gln Gln 
        195                 200                 205             


Gln Leu Gly Gln Glu Leu Lys Glu Leu Met Asn Thr Glu Gln Ala Leu 
    210                 215                 220                 


Asp Gln Leu Ile Gln Ser Cys Ser Leu Ser Phe Lys His Leu Thr Glu 
225                 230                 235                 240 


Asp Lys Ala Asn Lys Arg Leu Ala Tyr Val Thr Tyr Gln Asp Ile Arg 
                245                 250                 255     


Ala Val Gly Asn Phe Lys Glu Gln Thr Val Ile Ala Val Lys Ala Pro 
            260                 265                 270         


Pro Gln Thr Arg Leu Glu Val Pro Asp Arg Thr Glu Asp Asn Leu Gln 
        275                 280                 285             


Ile Tyr Leu Lys Ser Thr Gln Gly Pro Ile Glu Val Tyr Leu Cys Pro 
    290                 295                 300                 


Glu Glu Val Gln Glu Pro Asp Ser Pro Ser Glu Glu Pro Leu Pro Ser 
305                 310                 315                 320 


Thr Ser Thr Leu Cys Pro Ser Pro Asp Ser Ala Gln Pro Ser Ser Ser 
                325                 330                 335     


Thr Asp Pro Ser Ile Met Glu Pro Thr Ala Ser Ser Val Pro Ala Pro 
            340                 345                 350         


Ala Pro Thr Pro Gln Gln Ala Pro Pro Pro Pro Ser Leu Val Pro Leu 
        355                 360                 365             


Glu Ala Thr Asp Ser Leu Leu Glu Leu Pro His Pro Leu Leu Gln Gln 
    370                 375                 380                 


Thr Glu Asp Gln Phe Leu Ser Pro Thr Leu Ala Cys Ser Ser Pro Leu 
385                 390                 395                 400 


Ile Ser Phe Ser Pro Ser Leu Asp Gln Asp Asp Tyr Leu Trp Gly Leu 
                405                 410                 415     


Glu Ala Gly Glu Gly Ile Ser Asp Leu Phe Asp Ser Tyr Asp Leu Gly 
            420                 425                 430         


Asp Leu Leu Ile Asn 
        435         


<210>  211
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Arg Lys Gly Ile Gln Pro Ala Leu Glu Gln Tyr Leu Val Thr Ala 
1               5                   10                  15      


Gly Gly Gly Glu Gly Ala Ala Val Val Ala Ala Ala Ala Ala Ala Ser 
            20                  25                  30          


Met Asp Lys Arg Ala Leu Leu Ala Ser Pro Gly Phe Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Pro Gly Ala Tyr Ile Gln Ile Leu Thr Thr Asn 
    50                  55                  60                  


Thr Ser Thr Thr Ser Cys Ser Ser Ser Leu Gln Ser Gly Ala Val Ala 
65                  70                  75                  80  


Ala Gly Pro Leu Leu Pro Ser Ala Pro Gly Ala Glu Gln Thr Ala Gly 
                85                  90                  95      


Ser Leu Leu Tyr Thr Thr Pro His Gly Pro Ser Ser Arg Ala Gly Leu 
            100                 105                 110         


Leu Gln Gln Pro Pro Ala Leu Gly Arg Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Gly Pro Pro Ala Lys Arg Arg Leu Glu Leu Gly Glu Ser Gly His Gln 
    130                 135                 140                 


Tyr Leu Ser Asp Gly Leu Lys Thr Pro Lys Gly Lys Gly Arg Ala Ala 
145                 150                 155                 160 


Leu Arg Ser Pro Asp Ser Pro Lys Thr Pro Lys Ser Pro Ser Glu Lys 
                165                 170                 175     


Thr Arg Tyr Asp Thr Ser Leu Gly Leu Leu Thr Lys Lys Phe Ile Gln 
            180                 185                 190         


Leu Leu Ser Gln Ser Pro Asp Gly Val Leu Asp Leu Asn Lys Ala Ala 
        195                 200                 205             


Glu Val Leu Lys Val Gln Lys Arg Arg Ile Tyr Asp Ile Thr Asn Val 
    210                 215                 220                 


Leu Glu Gly Ile His Leu Ile Lys Lys Lys Ser Lys Asn Asn Val Gln 
225                 230                 235                 240 


Trp Met Gly Cys Ser Leu Ser Glu Asp Gly Gly Met Leu Ala Gln Cys 
                245                 250                 255     


Gln Gly Leu Ser Lys Glu Val Thr Glu Leu Ser Gln Glu Glu Lys Lys 
            260                 265                 270         


Leu Asp Glu Leu Ile Gln Ser Cys Thr Leu Asp Leu Lys Leu Leu Thr 
        275                 280                 285             


Glu Asp Ser Glu Asn Gln Arg Leu Ala Tyr Val Thr Tyr Gln Asp Ile 
    290                 295                 300                 


Arg Lys Ile Ser Gly Leu Lys Asp Gln Thr Val Ile Val Val Lys Ala 
305                 310                 315                 320 


Pro Pro Glu Thr Arg Leu Glu Val Pro Asp Ser Ile Glu Ser Leu Gln 
                325                 330                 335     


Ile His Leu Ala Ser Thr Gln Gly Pro Ile Glu Val Tyr Leu Cys Pro 
            340                 345                 350         


Glu Glu Thr Glu Thr His Ser Pro Met Lys Thr Asn Asn Gln Asp His 
        355                 360                 365             


Asn Gly Asn Ile Pro Lys Pro Ala Ser Lys Asp Leu Ala Ser Thr Asn 
    370                 375                 380                 


Ser Gly His Ser Asp Cys Ser Val Ser Met Gly Asn Leu Ser Pro Leu 
385                 390                 395                 400 


Ala Ser Pro Ala Asn Leu Leu Gln Gln Thr Glu Asp Gln Ile Pro Ser 
                405                 410                 415     


Asn Leu Glu Gly Pro Phe Val Asn Leu Leu Pro Pro Leu Leu Gln Glu 
            420                 425                 430         


Asp Tyr Leu Leu Ser Leu Gly Glu Glu Glu Gly Ile Ser Asp Leu Phe 
        435                 440                 445             


Asp Ala Tyr Asp Leu Glu Lys Leu Pro Leu Val Glu Asp Phe Met Cys 
    450                 455                 460                 


Ser 
465 


<210>  212
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ser Ser Arg Lys Ser Lys Ser Asn Ser Leu Ile His Thr Glu Cys 
1               5                   10                  15      


Leu Ser Gln Val Gln Arg Ile Leu Arg Glu Arg Phe Cys Arg Gln Ser 
            20                  25                  30          


Pro His Ser Asn Leu Phe Gly Val Gln Val Gln Tyr Lys His Leu Ser 
        35                  40                  45              


Glu Leu Leu Lys Arg Thr Ala Leu His Gly Glu Ser Asn Ser Val Leu 
    50                  55                  60                  


Ile Ile Gly Pro Arg Gly Ser Gly Lys Thr Met Leu Ile Asn His Ala 
65                  70                  75                  80  


Leu Lys Glu Leu Met Glu Ile Glu Glu Val Ser Glu Asn Val Leu Gln 
                85                  90                  95      


Val His Leu Asn Gly Leu Leu Gln Ile Asn Asp Lys Ile Ala Leu Lys 
            100                 105                 110         


Glu Ile Thr Arg Gln Leu Asn Leu Glu Asn Val Val Gly Asp Lys Val 
        115                 120                 125             


Phe Gly Ser Phe Ala Glu Asn Leu Ser Phe Leu Leu Glu Ala Leu Lys 
    130                 135                 140                 


Lys Gly Asp Arg Thr Ser Ser Cys Pro Val Ile Phe Ile Leu Asp Glu 
145                 150                 155                 160 


Phe Asp Leu Phe Ala His His Lys Asn Gln Thr Leu Leu Tyr Asn Leu 
                165                 170                 175     


Phe Asp Ile Ser Gln Ser Ala Gln Thr Pro Ile Ala Val Ile Gly Leu 
            180                 185                 190         


Thr Cys Arg Leu Asp Ile Leu Glu Leu Leu Glu Lys Arg Val Lys Ser 
        195                 200                 205             


Arg Phe Ser His Arg Gln Ile His Leu Met Asn Ser Phe Gly Phe Pro 
    210                 215                 220                 


Gln Tyr Val Lys Ile Phe Lys Glu Gln Leu Ser Leu Pro Ala Glu Phe 
225                 230                 235                 240 


Pro Asp Lys Val Phe Ala Glu Lys Trp Asn Glu Asn Val Gln Tyr Leu 
                245                 250                 255     


Ser Glu Asp Arg Ser Val Gln Glu Val Leu Gln Lys His Phe Asn Ile 
            260                 265                 270         


Ser Lys Asn Leu Arg Ser Leu His Met Leu Leu Met Leu Ala Leu Asn 
        275                 280                 285             


Arg Val Thr Ala Ser His Pro Phe Met Thr Ala Val Asp Leu Met Glu 
    290                 295                 300                 


Ala Ser Gln Leu Cys Ser Met Asp Ser Lys Ala Asn Ile Val His Gly 
305                 310                 315                 320 


Leu Ser Val Leu Glu Ile Cys Leu Ile Ile Ala Met Lys His Leu Asn 
                325                 330                 335     


Asp Ile Tyr Glu Glu Glu Pro Phe Asn Phe Gln Met Val Tyr Asn Glu 
            340                 345                 350         


Phe Gln Lys Phe Val Gln Arg Lys Ala His Ser Val Tyr Asn Phe Glu 
        355                 360                 365             


Lys Pro Val Val Met Lys Ala Phe Glu His Leu Gln Gln Leu Glu Leu 
    370                 375                 380                 


Ile Lys Pro Met Glu Arg Thr Ser Gly Asn Ser Gln Arg Glu Tyr Gln 
385                 390                 395                 400 


Leu Met Lys Leu Leu Leu Asp Asn Thr Gln Ile Met Asn Ala Leu Gln 
                405                 410                 415     


Lys Tyr Pro Asn Cys Pro Thr Asp Val Arg Gln Trp Ala Thr Ser Ser 
            420                 425                 430         


Leu Ser Trp Leu 
        435     


<210>  213
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Pro His Leu Glu Asn Val Val Leu Cys Arg Glu Ser Gln Val Ser 
1               5                   10                  15      


Ile Leu Gln Ser Leu Phe Gly Glu Arg His His Phe Ser Phe Pro Ser 
            20                  25                  30          


Ile Phe Ile Tyr Gly His Thr Ala Ser Gly Lys Thr Tyr Val Thr Gln 
        35                  40                  45              


Thr Leu Leu Lys Thr Leu Glu Leu Pro His Val Phe Val Asn Cys Val 
    50                  55                  60                  


Glu Cys Phe Thr Leu Arg Leu Leu Leu Glu Gln Ile Leu Asn Lys Leu 
65                  70                  75                  80  


Asn His Leu Ser Ser Ser Glu Asp Gly Cys Ser Thr Glu Ile Thr Cys 
                85                  90                  95      


Glu Thr Phe Asn Asp Phe Val Arg Leu Phe Lys Gln Val Thr Thr Ala 
            100                 105                 110         


Glu Asn Leu Lys Asp Gln Thr Val Tyr Ile Val Leu Asp Lys Ala Glu 
        115                 120                 125             


Tyr Leu Arg Asp Met Glu Ala Asn Leu Leu Pro Gly Phe Leu Arg Leu 
    130                 135                 140                 


Gln Glu Leu Ala Asp Arg Asn Val Thr Val Leu Phe Leu Ser Glu Ile 
145                 150                 155                 160 


Val Trp Glu Lys Phe Arg Pro Asn Thr Gly Cys Phe Glu Pro Phe Val 
                165                 170                 175     


Leu Tyr Phe Pro Asp Tyr Ser Ile Gly Asn Leu Gln Lys Ile Leu Ser 
            180                 185                 190         


His Asp His Pro Pro Glu Tyr Ser Ala Asp Phe Tyr Ala Ala Tyr Ile 
        195                 200                 205             


Asn Ile Leu Leu Gly Val Phe Tyr Thr Val Cys Arg Asp Leu Lys Glu 
    210                 215                 220                 


Leu Arg His Leu Ala Val Leu Asn Phe Pro Lys Tyr Cys Glu Pro Val 
225                 230                 235                 240 


Val Lys Gly Glu Ala Ser Glu Arg Asp Thr Arg Lys Leu Trp Arg Asn 
                245                 250                 255     


Ile Glu Pro His Leu Lys Lys Ala Met Gln Thr Val Tyr Leu Arg Glu 
            260                 265                 270         


Ile Ser Ser Ser Gln Trp Glu Lys Leu Gln Lys Asp Asp Thr Asp Pro 
        275                 280                 285             


Gly Gln Leu Lys Gly Leu Ser Ala His Thr His Val Glu Leu Pro Tyr 
    290                 295                 300                 


Tyr Ser Lys Phe Ile Leu Ile Ala Ala Tyr Leu Ala Ser Tyr Asn Pro 
305                 310                 315                 320 


Ala Arg Thr Asp Lys Arg Phe Phe Leu Lys His His Gly Lys Ile Lys 
                325                 330                 335     


Lys Thr Asn Phe Leu Lys Lys His Glu Lys Thr Ser Asn His Leu Leu 
            340                 345                 350         


Gly Pro Lys Pro Phe Pro Leu Asp Arg Leu Leu Ala Ile Leu Tyr Ser 
        355                 360                 365             


Ile Val Asp Ser Arg Val Ala Pro Thr Ala Asn Ile Phe Ser Gln Ile 
    370                 375                 380                 


Thr Ser Leu Val Thr Leu Gln Leu Leu Thr Leu Val Gly His Asp Asp 
385                 390                 395                 400 


Gln Leu Asp Gly Pro Lys Tyr Lys Cys Thr Val Ser Leu Asp Phe Ile 
                405                 410                 415     


Arg Ala Ile Ala Arg Thr Val Asn Phe Asp Ile Ile Lys Tyr Leu Tyr 
            420                 425                 430         


Asp Phe Leu 
        435 


<210>  214
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Leu Arg Arg Lys Pro Thr Arg Leu Glu Leu Lys Leu Asp Asp Ile 
1               5                   10                  15      


Glu Glu Phe Glu Asn Ile Arg Lys Asp Leu Glu Thr Arg Lys Lys Gln 
            20                  25                  30          


Lys Glu Asp Val Glu Val Val Gly Gly Ser Asp Gly Glu Gly Ala Ile 
        35                  40                  45              


Gly Leu Ser Ser Asp Pro Lys Ser Arg Glu Gln Met Ile Asn Asp Arg 
    50                  55                  60                  


Ile Gly Tyr Lys Pro Gln Pro Lys Pro Asn Asn Arg Ser Ser Gln Phe 
65                  70                  75                  80  


Gly Ser Leu Glu Phe 
                85  


<210>  215
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ser Gly Phe Asp Asp Pro Gly Ile Phe Tyr Ser Asp Ser Phe Gly 
1               5                   10                  15      


Gly Asp Ala Gln Ala Asp Glu Gly Gln Ala Arg Lys Ser Gln Leu Gln 
            20                  25                  30          


Arg Arg Phe Lys Glu Phe Leu Arg Gln Tyr Arg Val Gly Thr Asp Arg 
        35                  40                  45              


Thr Gly Phe Thr Phe Lys Tyr Arg Asp Glu Leu Lys Arg His Tyr Asn 
    50                  55                  60                  


Leu Gly Glu Tyr Trp Ile Glu Val Glu Met Glu Asp Leu Ala Ser Phe 
65                  70                  75                  80  


Asp Glu Asp Leu Ala Asp Tyr Leu Tyr Lys Gln Pro Ala Glu His Leu 
                85                  90                  95      


Gln Leu Leu Glu Glu Ala Ala Lys Glu Val Ala Asp Glu Val Thr Arg 
            100                 105                 110         


Pro Arg Pro Ser Gly Glu Glu Val Leu Gln Asp Ile Gln Val Met Leu 
        115                 120                 125             


Lys Ser Asp Ala Ser Pro Ser Ser Ile Arg Ser Leu Lys Ser Asp Met 
    130                 135                 140                 


Met Ser His Leu Val Lys Ile Pro Gly Ile Ile Ile Ala Ala Ser Ala 
145                 150                 155                 160 


Val Arg Ala Lys Ala Thr Arg Ile Ser Ile Gln Cys Arg Ser Cys Arg 
                165                 170                 175     


Asn Thr Leu Thr Asn Ile Ala Met Arg Pro Gly Leu Glu Gly Tyr Ala 
            180                 185                 190         


Leu Pro Arg Lys Cys Asn Thr Asp Gln Ala Gly Arg Pro Lys Cys Pro 
        195                 200                 205             


Leu Asp Pro Tyr Phe Ile Met Pro Asp Lys Cys Lys Cys Val Asp Phe 
    210                 215                 220                 


Gln Thr Leu Lys Leu Gln Glu Leu Pro Asp Ala Val Pro His Gly Glu 
225                 230                 235                 240 


Met Pro Arg His Met Gln Leu Tyr Cys Asp Arg Tyr Leu Cys Asp Lys 
                245                 250                 255     


Val Val Pro Gly Asn Arg Val Thr Ile Met Gly Ile Tyr Ser Ile Lys 
            260                 265                 270         


Lys Phe Gly Leu Thr Thr Ser Arg Gly Arg Asp Arg Val Gly Val Gly 
        275                 280                 285             


Ile Arg Ser Ser Tyr Ile Arg Val Leu Gly Ile Gln Val Asp Thr Asp 
    290                 295                 300                 


Gly Ser Gly Arg Ser Phe Ala Gly Ala Val Ser Pro Gln Glu Glu Glu 
305                 310                 315                 320 


Glu Phe Arg Arg Leu Ala Ala Leu Pro Asn Val Tyr Glu Val Ile Ser 
                325                 330                 335     


Lys Ser Ile Ala Pro Ser Ile Phe Gly Gly Thr Asp Met Lys Lys Ala 
            340                 345                 350         


Ile Ala Cys Leu Leu Phe Gly Gly Ser Arg Lys Arg Leu Pro Asp Gly 
        355                 360                 365             


Leu Thr Arg Arg Gly Asp Ile Asn Leu Leu Met Leu Gly Asp Pro Gly 
    370                 375                 380                 


Thr Ala Lys Ser Gln Leu Leu Lys Phe Val Glu Lys Cys Ser Pro Ile 
385                 390                 395                 400 


Gly Val Tyr Thr Ser Gly Lys Gly Ser Ser Ala Ala Gly Leu Thr Ala 
                405                 410                 415     


Ser Val Met Arg Asp Pro Ser Ser Arg Asn Phe Ile Met Glu Gly Gly 
            420                 425                 430         


Ala Met Val Leu Ala Asp Gly Gly Val Val Cys Ile Asp Glu Phe Asp 
        435                 440                 445             


Lys Met Arg Glu Asp Asp Arg Val Ala Ile His Glu Ala Met Glu Gln 
    450                 455                 460                 


Gln Thr Ile Ser Ile Ala Lys Ala Gly Ile Thr Thr Thr Leu Asn Ser 
465                 470                 475                 480 


Arg Cys Ser Val Leu Ala Ala Ala Asn Ser Val Phe Gly Arg Trp Asp 
                485                 490                 495     


Glu Thr Lys Gly Glu Asp Asn Ile Asp Phe Met Pro Thr Ile Leu Ser 
            500                 505                 510         


Arg Phe Asp Met Ile Phe Ile Val Lys Asp Glu His Asn Glu Glu Arg 
        515                 520                 525             


Asp Val Met Leu Ala Lys His Val Ile Thr Leu His Val Ser Ala Leu 
    530                 535                 540                 


Thr Gln Thr Gln Ala Val Glu Gly Glu Ile Asp Leu Ala Lys Leu Lys 
545                 550                 555                 560 


Lys Phe Ile Ala Tyr Cys Arg Val Lys Cys Gly Pro Arg Leu Ser Ala 
                565                 570                 575     


Glu Ala Ala Glu Lys Leu Lys Asn Arg Tyr Ile Ile Met Arg Ser Gly 
            580                 585                 590         


Ala Arg Gln His Glu Arg Asp Ser Asp Arg Arg Ser Ser Ile Pro Ile 
        595                 600                 605             


Thr Val Arg Gln Leu Glu Ala Ile Val Arg Ile Ala Glu Ala Leu Ser 
    610                 615                 620                 


Lys Met Lys Leu Gln Pro Phe Ala Thr Glu Ala Asp Val Glu Glu Ala 
625                 630                 635                 640 


Leu Arg Leu Phe Gln Val Ser Thr Leu Asp Ala Ala Leu Ser Gly Thr 
                645                 650                 655     


Leu Ser Gly Val Glu Gly Phe Thr Ser Gln Glu Asp Gln Glu Met Leu 
            660                 665                 670         


Ser Arg Ile Glu Lys Gln Leu Lys Arg Arg Phe Ala Ile Gly Ser Gln 
        675                 680                 685             


Val Ser Glu His Ser Ile Ile Lys Asp Phe Thr Lys Gln Lys Tyr Pro 
    690                 695                 700                 


Glu His Ala Ile His Lys Val Leu Gln Leu Met Leu Arg Arg Gly Glu 
705                 710                 715                 720 


Ile Gln His Arg Met Gln Arg Lys Val Leu Tyr Arg Leu Lys 
                725                 730                 


<210>  216
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Ile Ala Ala Pro Glu Ile Pro Thr Asp Phe Asn Leu Leu Gln Glu 
1               5                   10                  15      


Ser Glu Thr His Phe Ser Ser Asp Thr Asp Phe Glu Asp Ile Glu Gly 
            20                  25                  30          


Lys Asn Gln Lys Gln Gly Lys Gly Lys Thr Cys Lys Lys Gly Lys Lys 
        35                  40                  45              


Gly Pro Ala Glu Lys Gly Lys Gly Gly Asn Gly Gly Gly Lys Pro Pro 
    50                  55                  60                  


Ser Gly Pro Asn Arg Met Asn Gly His His Gln Gln Asn Gly Val Glu 
65                  70                  75                  80  


Asn Met Met Leu Phe Glu Val Val Lys Met Gly Lys Ser Ala Met Gln 
                85                  90                  95      


Ser Val Val Asp Asp Trp Ile Glu Ser Tyr Lys His Asp Arg Asp Ile 
            100                 105                 110         


Ala Leu Leu Asp Leu Ile Asn Phe Phe Ile Gln Cys Ser Gly Cys Lys 
        115                 120                 125             


Gly Val Val Thr Ala Glu Met Phe Arg His Met Gln Asn Ser Glu Ile 
    130                 135                 140                 


Ile Arg Lys Met Thr Glu Glu Phe Asp Glu Asp Ser Gly Asp Tyr Pro 
145                 150                 155                 160 


Leu Thr Met Ala Gly Pro Gln Trp Lys Lys Phe Lys Ser Ser Phe Cys 
                165                 170                 175     


Glu Phe Ile Gly Val Leu Val Arg Gln Cys Gln Tyr Ser Ile Ile Tyr 
            180                 185                 190         


Asp Glu Tyr Met Met Asp Thr Val Ile Ser Leu Leu Thr Gly Leu Ser 
        195                 200                 205             


Asp Ser Gln Val Arg Ala Phe Arg His Thr Ser Thr Leu Ala Ala Met 
    210                 215                 220                 


Lys Leu Met Thr Ala Leu Val Asn Val Ala Leu Asn Leu Ser Ile Asn 
225                 230                 235                 240 


Met Asp Asn Thr Gln Arg Gln Tyr Glu Ala Glu Arg Asn Lys Met Ile 
                245                 250                 255     


Gly Lys Arg Ala Asn Glu Arg Leu Glu Leu Leu Leu Gln Lys Arg Lys 
            260                 265                 270         


Glu Leu Gln Glu Asn Gln Asp Glu Ile Glu Asn Met Met Asn Ala Ile 
        275                 280                 285             


Phe Lys Gly Val Phe Val His Arg Tyr Arg Asp Ala Ile Ala Glu Ile 
    290                 295                 300                 


Arg Ala Ile Cys Ile Glu Glu Ile Gly Ile Trp Met Lys Met Tyr Ser 
305                 310                 315                 320 


Asp Ala Phe Leu Asn Asp Ser Tyr Leu Lys Tyr Val Gly Trp Thr Met 
                325                 330                 335     


His Asp Lys Gln Gly Glu Val Arg Leu Lys Cys Leu Thr Ala Leu Gln 
            340                 345                 350         


Gly Leu Tyr Tyr Asn Lys Glu Leu Asn Ser Lys Leu Glu Leu Phe Thr 
        355                 360                 365             


Ser Arg Phe Lys Asp Arg Ile Val Ser Met Thr Leu Asp Lys Glu Tyr 
    370                 375                 380                 


Asp Val Ala Val Gln Ala Ile Lys Leu Leu Thr Leu Val Leu Gln Ser 
385                 390                 395                 400 


Ser Glu Glu Val Leu Thr Ala Glu Asp Cys Glu Asn Val Tyr His Leu 
                405                 410                 415     


Val Tyr Ser Ala His Arg Pro Val Ala Val Ala Ala Gly Glu Phe Leu 
            420                 425                 430         


Tyr Lys Lys Leu Phe Ser Arg Arg Asp Pro Glu Glu Asp Gly Met Met 
        435                 440                 445             


Lys Arg Arg Gly Arg Gln Gly Pro Asn Ala Asn Leu Val Lys Thr Leu 
    450                 455                 460                 


Val Phe Phe Phe Leu Glu Ser Glu Leu His Glu His Ala Ala Tyr Leu 
465                 470                 475                 480 


Val Asp Ser Met Trp Asp Cys Ala Thr Glu Leu Leu Lys Asp Trp Glu 
                485                 490                 495     


Cys Met Asn Ser Leu Leu Leu Glu Glu Pro Leu Ser Gly Glu Glu Ala 
            500                 505                 510         


Leu Thr Asp Arg Gln Glu Ser Ala Leu Ile Glu Ile Met Leu Cys Thr 
        515                 520                 525             


Ile Arg Gln Ala Ala Glu Cys His Pro Pro Val Gly Arg Gly Thr Gly 
    530                 535                 540                 


Lys Arg Val Leu Thr Ala Lys Glu Lys Lys Thr Gln Leu Asp Asp Arg 
545                 550                 555                 560 


Thr Lys Ile Thr Glu Leu Phe Ala Val Ala Leu Pro Gln Leu Leu Ala 
                565                 570                 575     


Lys Tyr Ser Val Asp Ala Glu Lys Val Thr Asn Leu Leu Gln Leu Pro 
            580                 585                 590         


Gln Tyr Phe Asp Leu Glu Ile Tyr Thr Thr Gly Arg Leu Glu Lys His 
        595                 600                 605             


Leu Asp Ala Leu Leu Arg Gln Ile Arg Asn Ile Val Glu Lys His Thr 
    610                 615                 620                 


Asp Thr Asp Val Leu Glu Ala Cys Ser Lys Thr Tyr His Ala Leu Cys 
625                 630                 635                 640 


Asn Glu Glu Phe Thr Ile Phe Asn Arg Val Asp Ile Ser Arg Ser Gln 
                645                 650                 655     


Leu Ile Asp Glu Leu Ala Asp Lys Phe Asn Arg Leu Leu Glu Asp Phe 
            660                 665                 670         


Leu Gln Glu Gly Glu Glu Pro Asp Glu Asp Asp Ala Tyr Gln Val Leu 
        675                 680                 685             


Ser Thr Leu Lys Arg Ile Thr Ala Phe His Asn Ala His Asp Leu Ser 
    690                 695                 700                 


Lys Trp Asp Leu Phe Ala Cys Asn Tyr Lys Leu Leu Lys Thr Gly Ile 
705                 710                 715                 720 


Glu Asn Gly Asp Met Pro Glu Gln Ile Val Ile His Ala Leu Gln Cys 
                725                 730                 735     


Thr His Tyr Val Ile Leu Trp Gln Leu Ala Lys Ile Thr Glu Ser Ser 
            740                 745                 750         


Ser Thr Lys Glu Asp Leu Leu Arg Leu Lys Lys Gln Met Arg Val Phe 
        755                 760                 765             


Cys Gln Ile Cys Gln His Tyr Leu Thr Asn Val Asn Thr Thr Val Lys 
    770                 775                 780                 


Glu Gln Ala Phe Thr Ile Leu Cys Asp Ile Leu Met Ile Phe Ser His 
785                 790                 795                 800 


Gln Ile Met Ser Gly Gly Arg Asp Met Leu Glu Pro Leu Val Tyr Thr 
                805                 810                 815     


Pro Asp Ser Ser Leu Gln Ser Glu Leu Leu Ser Phe Ile Leu Asp His 
            820                 825                 830         


Val Phe Ile Glu Gln Asp Asp Asp Asn Asn Ser Ala Asp Gly Gln Gln 
        835                 840                 845             


Glu Asp Glu Ala Ser Lys Ile Glu Ala Leu His Lys Arg Arg Asn Leu 
    850                 855                 860                 


Leu Ala Ala Phe Cys Lys Leu Ile Val Tyr Thr Val Val Glu Met Asn 
865                 870                 875                 880 


Thr Ala Ala Asp Ile Phe Lys Gln Tyr Met Lys Tyr Tyr Asn Asp Tyr 
                885                 890                 895     


Gly Asp Ile Ile Lys Glu Thr Met Ser Lys Thr Arg Gln Ile Asp Lys 
            900                 905                 910         


Ile Gln Cys Ala Lys Thr Leu Ile Leu Ser Leu Gln Gln Leu Phe Asn 
        915                 920                 925             


Glu Met Ile Gln Glu Asn Gly Tyr Asn Phe Asp Arg Ser Ser Ser Thr 
    930                 935                 940                 


Phe Ser Gly Ile Lys Glu Leu Ala Arg Arg Phe Ala Leu Thr Phe Gly 
945                 950                 955                 960 


Leu Asp Gln Leu Lys Thr Arg Glu Ala Ile Ala Met Leu His Lys Asp 
                965                 970                 975     


Gly Ile Glu Phe Ala Phe Lys Glu Pro Asn Pro Gln Gly Glu Ser His 
            980                 985                 990         


Pro Pro Leu Asn Leu Ala Phe Leu  Asp Ile Leu Ser Glu  Phe Ser Ser 
        995                 1000                 1005             


Lys Leu  Leu Arg Gln Asp Lys  Arg Thr Val Tyr Val  Tyr Leu Glu 
    1010                 1015                 1020             


Lys Phe  Met Thr Phe Gln Met  Ser Leu Arg Arg Glu  Asp Val Trp 
    1025                 1030                 1035             


Leu Pro  Leu Met Ser Tyr Arg  Asn Ser Leu Leu Ala  Gly Gly Asp 
    1040                 1045                 1050             


Asp Asp  Thr Met Ser Val Ile  Ser Gly Ile Ser Ser  Arg Gly Ser 
    1055                 1060                 1065             


Thr Val  Arg Ser Lys Lys Ser  Lys Pro Ser Thr Gly  Lys Arg Lys 
    1070                 1075                 1080             


Val Val  Glu Gly Met Gln Leu  Ser Leu Thr Glu Glu  Ser Ser Ser 
    1085                 1090                 1095             


Ser Asp  Ser Met Trp Leu Ser  Arg Glu Gln Thr Leu  His Thr Pro 
    1100                 1105                 1110             


Val Met  Met Gln Thr Pro Gln  Leu Thr Ser Thr Ile  Met Arg Glu 
    1115                 1120                 1125             


Pro Lys  Arg Leu Arg Pro Glu  Asp Ser Phe Met Ser  Val Tyr Pro 
    1130                 1135                 1140             


Met Gln  Thr Glu His His Gln  Thr Pro Leu Asp Tyr  Asn Arg Arg 
    1145                 1150                 1155             


Gly Thr  Ser Leu Met Glu Asp  Asp Glu Glu Pro Ile  Val Glu Asp 
    1160                 1165                 1170             


Val Met  Met Ser Ser Glu Gly  Arg Ile Glu Asp Leu  Asn Glu Gly 
    1175                 1180                 1185             


Met Asp  Phe Asp Thr Met Asp  Ile Asp Leu Pro Pro  Ser Lys Asn 
    1190                 1195                 1200             


Arg Arg  Glu Arg Thr Glu Leu  Lys Pro Asp Phe Phe  Asp Pro Ala 
    1205                 1210                 1215             


Ser Ile  Met Asp Glu Ser Val  Leu Gly Val Ser Met  Phe 
    1220                 1225                 1230     


<210>  217
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15      


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30          


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45              


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60                  


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95      


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly 
            100                 105                 110         


Ile Asp Val Val Arg Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val 
        115                 120                 125             


Thr Leu Pro Lys Gly Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp 
    130                 135                 140                 


Ser Met Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile 
145                 150                 155                 160 


Tyr Ser Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys 
                165                 170                 175     


Ile Ile Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys 
            180                 185                 190         


Leu Thr Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys 
        195                 200                 205             


Glu Arg Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr 
    210                 215                 220                 


Ala Gln Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe 
225                 230                 235                 240 


Ser Gly Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp 
                245                 250                 255     


Glu Pro His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn 
            260                 265                 270         


Ala Asn Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu 
        275                 280                 285             


Gly Tyr Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys 
    290                 295                 300                 


Thr Phe Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile 
305                 310                 315                 320 


Gly Tyr Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln 
                325                 330                 335     


Met Ala Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val 
            340                 345                 350         


Ala Ser 
        


<210>  218
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Gln Ala Phe Leu Lys Gly Thr Ser Ile Ser Thr Lys Pro Pro Leu 
1               5                   10                  15      


Thr Lys Asp Arg Gly Val Ala Ala Ser Ala Gly Ser Ser Gly Glu Asn 
            20                  25                  30          


Lys Lys Ala Lys Pro Val Pro Trp Val Glu Lys Tyr Arg Pro Lys Cys 
        35                  40                  45              


Val Asp Glu Val Ala Phe Gln Glu Glu Val Val Ala Val Leu Lys Lys 
    50                  55                  60                  


Ser Leu Glu Gly Ala Asp Leu Pro Asn Leu Leu Phe Tyr Gly Pro Pro 
65                  70                  75                  80  


Gly Thr Gly Lys Thr Ser Thr Ile Leu Ala Ala Ala Arg Glu Leu Phe 
                85                  90                  95      


Gly Pro Glu Leu Phe Arg Leu Arg Val Leu Glu Leu Asn Ala Ser Asp 
            100                 105                 110         


Glu Arg Gly Ile Gln Val Val Arg Glu Lys Val Lys Asn Phe Ala Gln 
        115                 120                 125             


Leu Thr Val Ser Gly Ser Arg Ser Asp Gly Lys Pro Cys Pro Pro Phe 
    130                 135                 140                 


Lys Ile Val Ile Leu Asp Glu Ala Asp Ser Met Thr Ser Ala Ala Gln 
145                 150                 155                 160 


Ala Ala Leu Arg Arg Thr Met Glu Lys Glu Ser Lys Thr Thr Arg Phe 
                165                 170                 175     


Cys Leu Ile Cys Asn Tyr Val Ser Arg Ile Ile Glu Pro Leu Thr Ser 
            180                 185                 190         


Arg Cys Ser Lys Phe Arg Phe Lys Pro Leu Ser Asp Lys Ile Gln Gln 
        195                 200                 205             


Gln Arg Leu Leu Asp Ile Ala Lys Lys Glu Asn Val Lys Ile Ser Asp 
    210                 215                 220                 


Glu Gly Ile Ala Tyr Leu Val Lys Val Ser Glu Gly Asp Leu Arg Lys 
225                 230                 235                 240 


Ala Ile Thr Phe Leu Gln Ser Ala Thr Arg Leu Thr Gly Gly Lys Glu 
                245                 250                 255     


Ile Thr Glu Lys Val Ile Thr Asp Ile Ala Gly Val Ile Pro Ala Glu 
            260                 265                 270         


Lys Ile Asp Gly Val Phe Ala Ala Cys Gln Ser Gly Ser Phe Asp Lys 
        275                 280                 285             


Leu Glu Ala Val Val Lys Asp Leu Ile Asp Glu Gly His Ala Ala Thr 
    290                 295                 300                 


Gln Leu Val Asn Gln Leu His Asp Val Val Val Glu Asn Asn Leu Ser 
305                 310                 315                 320 


Asp Lys Gln Lys Ser Ile Ile Thr Glu Lys Leu Ala Glu Val Asp Lys 
                325                 330                 335     


Cys Leu Ala Asp Gly Ala Asp Glu His Leu Gln Leu Ile Ser Leu Cys 
            340                 345                 350         


Ala Thr Val Met Gln Gln Leu Ser Gln Asn Cys 
        355                 360             


<210>  219
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Glu Thr Ser Ala Leu Lys Gln Gln Glu Gln Pro Ala Ala Thr Lys 
1               5                   10                  15      


Ile Arg Asn Leu Pro Trp Val Glu Lys Tyr Arg Pro Gln Thr Leu Asn 
            20                  25                  30          


Asp Leu Ile Ser His Gln Asp Ile Leu Ser Thr Ile Gln Lys Phe Ile 
        35                  40                  45              


Asn Glu Asp Arg Leu Pro His Leu Leu Leu Tyr Gly Pro Pro Gly Thr 
    50                  55                  60                  


Gly Lys Thr Ser Thr Ile Leu Ala Cys Ala Lys Gln Leu Tyr Lys Asp 
65                  70                  75                  80  


Lys Glu Phe Gly Ser Met Val Leu Glu Leu Asn Ala Ser Asp Asp Arg 
                85                  90                  95      


Gly Ile Asp Ile Ile Arg Gly Pro Ile Leu Ser Phe Ala Ser Thr Arg 
            100                 105                 110         


Thr Ile Phe Lys Lys Gly Phe Lys Leu Val Ile Leu Asp Glu Ala Asp 
        115                 120                 125             


Ala Met Thr Gln Asp Ala Gln Asn Ala Leu Arg Arg Val Ile Glu Lys 
    130                 135                 140                 


Phe Thr Glu Asn Thr Arg Phe Cys Leu Ile Cys Asn Tyr Leu Ser Lys 
145                 150                 155                 160 


Ile Ile Pro Ala Leu Gln Ser Arg Cys Thr Arg Phe Arg Phe Gly Pro 
                165                 170                 175     


Leu Thr Pro Glu Leu Met Val Pro Arg Leu Glu His Val Val Glu Glu 
            180                 185                 190         


Glu Lys Val Asp Ile Ser Glu Asp Gly Met Lys Ala Leu Val Thr Leu 
        195                 200                 205             


Ser Ser Gly Asp Met Arg Arg Ala Leu Asn Ile Leu Gln Ser Thr Asn 
    210                 215                 220                 


Met Ala Phe Gly Lys Val Thr Glu Glu Thr Val Tyr Thr Cys Thr Gly 
225                 230                 235                 240 


His Pro Leu Lys Ser Asp Ile Ala Asn Ile Leu Asp Trp Met Leu Asn 
                245                 250                 255     


Gln Asp Phe Thr Thr Ala Tyr Arg Asn Ile Thr Glu Leu Lys Thr Leu 
            260                 265                 270         


Lys Gly Leu Ala Leu His Asp Ile Leu Thr Glu Ile His Leu Phe Val 
        275                 280                 285             


His Arg Val Asp Phe Pro Ser Ser Val Arg Ile His Leu Leu Thr Lys 
    290                 295                 300                 


Met Ala Asp Ile Glu Tyr Arg Leu Ser Val Gly Thr Asn Glu Lys Ile 
305                 310                 315                 320 


Gln Leu Ser Ser Leu Ile Ala Ala Phe Gln Val Thr Arg Asp Leu Ile 
                325                 330                 335     


Val Ala Glu Ala 
            340 


<210>  220
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 
1               5                   10                  15      


Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 
        35                  40                  45              


Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 
    50                  55                  60                  


Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 
65                  70                  75                  80  


Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 
                85                  90                  95      


Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 
            100                 105                 110         


Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 
        115                 120                 125             


Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 
    130                 135                 140                 


Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 
145                 150                 155                 160 


Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 
                165                 170                 175     


Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 
            180                 185                 190         


Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 
        195                 200                 205             


Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 
    210                 215                 220                 


Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 
225                 230                 235                 240 


Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 
                245                 250                 255     


Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 
            260                 265                 270 


<210>  221
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     


<210>  222
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Ala Pro Lys Lys Arg Pro Glu Thr Gln Lys Thr Ser Glu Ile Val 
1               5                   10                  15      


Leu Arg Pro Arg Asn Lys Arg Ser Arg Ser Pro Leu Glu Leu Glu Pro 
            20                  25                  30          


Glu Ala Lys Lys Leu Cys Ala Lys Gly Ser Gly Pro Ser Arg Arg Cys 
        35                  40                  45              


Asp Ser Asp Cys Leu Trp Val Gly Leu Ala Gly Pro Gln Ile Leu Pro 
    50                  55                  60                  


Pro Cys Arg Ser Ile Val Arg Thr Leu His Gln His Lys Leu Gly Arg 
65                  70                  75                  80  


Ala Ser Trp Pro Ser Val Gln Gln Gly Leu Gln Gln Ser Phe Leu His 
                85                  90                  95      


Thr Leu Asp Ser Tyr Arg Ile Leu Gln Lys Ala Ala Pro Phe Asp Arg 
            100                 105                 110         


Arg Ala Thr Ser Leu Ala Trp His Pro Thr His Pro Ser Thr Val Ala 
        115                 120                 125             


Val Gly Ser Lys Gly Gly Asp Ile Met Leu Trp Asn Phe Gly Ile Lys 
    130                 135                 140                 


Asp Lys Pro Thr Phe Ile Lys Gly Ile Gly Ala Gly Gly Ser Ile Thr 
145                 150                 155                 160 


Gly Leu Lys Phe Asn Pro Leu Asn Thr Asn Gln Phe Tyr Ala Ser Ser 
                165                 170                 175     


Met Glu Gly Thr Thr Arg Leu Gln Asp Phe Lys Gly Asn Ile Leu Arg 
            180                 185                 190         


Val Phe Ala Ser Ser Asp Thr Ile Asn Ile Trp Phe Cys Ser Leu Asp 
        195                 200                 205             


Val Ser Ala Ser Ser Arg Met Val Val Thr Gly Asp Asn Val Gly Asn 
    210                 215                 220                 


Val Ile Leu Leu Asn Met Asp Gly Lys Glu Leu Trp Asn Leu Arg Met 
225                 230                 235                 240 


His Lys Lys Lys Val Thr His Val Ala Leu Asn Pro Cys Cys Asp Trp 
                245                 250                 255     


Phe Leu Ala Thr Ala Ser Val Asp Gln Thr Val Lys Ile Trp Asp Leu 
            260                 265                 270         


Arg Gln Val Arg Gly Lys Ala Ser Phe Leu Tyr Ser Leu Pro His Arg 
        275                 280                 285             


His Pro Val Asn Ala Ala Cys Phe Ser Pro Asp Gly Ala Arg Leu Leu 
    290                 295                 300                 


Thr Thr Asp Gln Lys Ser Glu Ile Arg Val Tyr Ser Ala Ser Gln Trp 
305                 310                 315                 320 


Asp Cys Pro Leu Gly Leu Ile Pro His Pro His Arg His Phe Gln His 
                325                 330                 335     


Leu Thr Pro Ile Lys Ala Ala Trp His Pro Arg Tyr Asn Leu Ile Val 
            340                 345                 350         


Val Gly Arg Tyr Pro Asp Pro Asn Phe Lys Ser Cys Thr Pro Tyr Glu 
        355                 360                 365             


Leu Arg Thr Ile Asp Val Phe Asp Gly Asn Ser Gly Lys Met Met Cys 
    370                 375                 380                 


Gln Leu Tyr Asp Pro Glu Ser Ser Gly Ile Ser Ser Leu Asn Glu Phe 
385                 390                 395                 400 


Asn Pro Met Gly Asp Thr Leu Ala Ser Ala Met Gly Tyr His Ile Leu 
                405                 410                 415     


Ile Trp Ser Gln Glu Glu Ala Arg Thr Arg Lys 
            420                 425         


<210>  223
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Ser Glu Asp Leu Ala Lys Gln Leu Ala Ser Tyr Lys Ala Gln Leu 
1               5                   10                  15      


Gln Gln Val Glu Ala Ala Leu Ser Gly Asn Gly Glu Asn Glu Asp Leu 
            20                  25                  30          


Leu Lys Leu Lys Lys Asp Leu Gln Glu Val Ile Glu Leu Thr Lys Asp 
        35                  40                  45              


Leu Leu Ser Thr Gln Pro Ser Glu Thr Leu Ala Ser Ser Asp Ser Phe 
    50                  55                  60                  


Ala Ser Thr Gln Pro Thr His Ser Trp Lys Val Gly Asp Lys Cys Met 
65                  70                  75                  80  


Ala Val Trp Ser Glu Asp Gly Gln Cys Tyr Glu Ala Glu Ile Glu Glu 
                85                  90                  95      


Ile Asp Glu Glu Asn Gly Thr Ala Ala Ile Thr Phe Ala Gly Tyr Gly 
            100                 105                 110         


Asn Ala Glu Val Thr Pro Leu Leu Asn Leu Lys Pro Val Glu Glu Gly 
        115                 120                 125             


Arg Lys Ala Lys Glu Asp Ser Gly Asn Lys Pro Met Ser Lys Lys Glu 
    130                 135                 140                 


Met Ile Ala Gln Gln Arg Glu Tyr Lys Lys Lys Lys Ala Leu Lys Lys 
145                 150                 155                 160 


Ala Gln Arg Ile Lys Glu Leu Glu Gln Glu Arg Glu Asp Gln Lys Val 
                165                 170                 175     


Lys Trp Gln Gln Phe Asn Asn Arg Ala Tyr Ser Lys Asn Lys Lys Gly 
            180                 185                 190         


Gln Val Lys Arg Ser Ile Phe Ala Ser Pro Glu Ser Val Thr Gly Lys 
        195                 200                 205             


Val Gly Val Gly Thr Cys Gly Ile Ala Asp Lys Pro Met Thr Gln Tyr 
    210                 215                 220                 


Gln Asp Thr Ser Lys Tyr Asn Val Arg His Leu Met Pro Gln 
225                 230                 235             


<210>  224
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Pro Ala Gly Pro Val Gln Ala Val Pro Pro Pro Pro Pro Val Pro 
1               5                   10                  15      


Thr Glu Pro Lys Gln Pro Thr Glu Glu Glu Ala Ser Ser Lys Glu Asp 
            20                  25                  30          


Ser Ala Pro Ser Lys Pro Val Val Gly Ile Ile Tyr Pro Pro Pro Glu 
        35                  40                  45              


Val Arg Asn Ile Val Asp Lys Thr Ala Ser Phe Val Ala Arg Asn Gly 
    50                  55                  60                  


Pro Glu Phe Glu Ala Arg Ile Arg Gln Asn Glu Ile Asn Asn Pro Lys 
65                  70                  75                  80  


Phe Asn Phe Leu Asn Pro Asn Asp Pro Tyr His Ala Tyr Tyr Arg His 
                85                  90                  95      


Lys Val Ser Glu Phe Lys Glu Gly Lys Ala Gln Glu Pro Ser Ala Ala 
            100                 105                 110         


Ile Pro Lys Val Met Gln Gln Gln Gln Gln Thr Thr Gln Gln Gln Leu 
        115                 120                 125             


Pro Gln Lys Val Gln Ala Gln Val Ile Gln Glu Thr Ile Val Pro Lys 
    130                 135                 140                 


Glu Pro Pro Pro Glu Phe Glu Phe Ile Ala Asp Pro Pro Ser Ile Ser 
145                 150                 155                 160 


Ala Phe Asp Leu Asp Val Val Lys Leu Thr Ala Gln Phe Val Ala Arg 
                165                 170                 175     


Asn Gly Arg Gln Phe Leu Thr Gln Leu Met Gln Lys Glu Gln Arg Asn 
            180                 185                 190         


Tyr Gln Phe Asp Phe Leu Arg Pro Gln His Ser Leu Phe Asn Tyr Phe 
        195                 200                 205             


Thr Lys Leu Val Glu Gln Tyr Thr Lys Ile Leu Ile Pro Pro Lys Gly 
    210                 215                 220                 


Leu Phe Ser Lys Leu Lys Lys Glu Ala Glu Asn Pro Arg Glu Val Leu 
225                 230                 235                 240 


Asp Gln Val Cys Tyr Arg Val Glu Trp Ala Lys Phe Gln Glu Arg Glu 
                245                 250                 255     


Arg Lys Lys Glu Glu Glu Glu Lys Glu Lys Glu Arg Val Ala Tyr Ala 
            260                 265                 270         


Gln Ile Asp Trp His Asp Phe Val Val Val Glu Thr Val Asp Phe Gln 
        275                 280                 285             


Pro Asn Glu Gln Gly Asn Phe Pro Pro Pro Thr Thr Pro Glu Glu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Ile Gln Glu Arg Tyr Glu Lys Phe Gly Glu Ser 
305                 310                 315                 320 


Glu Glu Val Glu Met Glu Val Glu Ser Asp Glu Glu Asp Asp Lys Gln 
                325                 330                 335     


Glu Lys Ala Glu Glu Pro Pro Ser Gln Leu Asp Gln Asp Thr Gln Val 
            340                 345                 350         


Gln Asp Met Asp Glu Gly Ser Asp Asp Glu Glu Glu Gly Gln Lys Val 
        355                 360                 365             


Pro Pro Pro Pro Glu Thr Pro Met Pro Pro Pro Leu Pro Pro Thr Pro 
    370                 375                 380                 


Asp Gln Val Ile Val Arg Lys Asp Tyr Asp Pro Lys Ala Ser Lys Pro 
385                 390                 395                 400 


Leu Pro Pro Ala Pro Ala Pro Asp Glu Tyr Leu Val Ser Pro Ile Thr 
                405                 410                 415     


Gly Glu Lys Ile Pro Ala Ser Lys Met Gln Glu His Met Arg Ile Gly 
            420                 425                 430         


Leu Leu Asp Pro Arg Trp Leu Glu Gln Arg Asp Arg Ser Ile Arg Glu 
        435                 440                 445             


Lys Gln Ser Asp Asp Glu Val Tyr Ala Pro Gly Leu Asp Ile Glu Ser 
    450                 455                 460                 


Ser Leu Lys Gln Leu Ala Glu Arg Arg Thr Asp Ile Phe Gly Val Glu 
465                 470                 475                 480 


Glu Thr Ala Ile Gly Lys Lys Ile Gly Glu Glu Glu Ile Gln Lys Pro 
                485                 490                 495     


Glu Glu Lys Val Thr Trp Asp Gly His Ser Gly Ser Met Ala Arg Thr 
            500                 505                 510         


Gln Gln Ala Ala Gln Ala Asn Ile Thr Leu Gln Glu Gln Ile Glu Ala 
        515                 520                 525             


Ile His Lys Ala Lys Gly Leu Val Pro Glu Asp Asp Thr Lys Glu Lys 
    530                 535                 540                 


Ile Gly Pro Ser Lys Pro Asn Glu Ile Pro Gln Gln Pro Pro Pro Pro 
545                 550                 555                 560 


Ser Ser Ala Thr Asn Ile Pro Ser Ser Ala Pro Pro Ile Thr Ser Val 
                565                 570                 575     


Pro Arg Pro Pro Thr Met Pro Pro Pro Val Arg Thr Thr Val Val Ser 
            580                 585                 590         


Ala Val Pro Val Met Pro Arg Pro Pro Met Ala Ser Val Val Arg Leu 
        595                 600                 605             


Pro Pro Gly Ser Val Ile Ala Pro Met Pro Pro Ile Ile His Ala Pro 
    610                 615                 620                 


Arg Ile Asn Val Val Pro Met Pro Pro Ser Ala Pro Pro Ile Met Ala 
625                 630                 635                 640 


Pro Arg Pro Pro Pro Met Ile Val Pro Thr Ala Phe Val Pro Ala Pro 
                645                 650                 655     


Pro Val Ala Pro Val Pro Ala Pro Ala Pro Met Pro Pro Val His Pro 
            660                 665                 670         


Pro Pro Pro Met Glu Asp Glu Pro Thr Ser Lys Lys Leu Lys Thr Glu 
        675                 680                 685             


Asp Ser Leu Met Pro Glu Glu Glu Phe Leu Arg Arg Asn Lys Gly Pro 
    690                 695                 700                 


Val Ser Ile Lys Val Gln Val Pro Asn Met Gln Asp Lys Thr Glu Trp 
705                 710                 715                 720 


Lys Leu Asn Gly Gln Val Leu Val Phe Thr Leu Pro Leu Thr Asp Gln 
                725                 730                 735     


Val Ser Val Ile Lys Val Lys Ile His Glu Ala Thr Gly Met Pro Ala 
            740                 745                 750         


Gly Lys Gln Lys Leu Gln Tyr Glu Gly Ile Phe Ile Lys Asp Ser Asn 
        755                 760                 765             


Ser Leu Ala Tyr Tyr Asn Met Ala Asn Gly Ala Val Ile His Leu Ala 
    770                 775                 780                 


Leu Lys Glu Arg Gly Gly Arg Lys Lys 
785                 790             


<210>  225
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Ser Asp Phe Asp Glu Phe Glu Arg Gln Leu Asn Glu Asn Lys Gln 
1               5                   10                  15      


Glu Arg Asp Lys Glu Asn Arg His Arg Lys Arg Ser His Ser Arg Ser 
            20                  25                  30          


Arg Ser Arg Asp Arg Lys Arg Arg Ser Arg Ser Arg Asp Arg Arg Asn 
        35                  40                  45              


Arg Asp Gln Arg Ser Ala Ser Arg Asp Arg Arg Arg Arg Ser Lys Pro 
    50                  55                  60                  


Leu Thr Arg Gly Ala Lys Glu Glu His Gly Gly Leu Ile Arg Ser Pro 
65                  70                  75                  80  


Arg His Glu Lys Lys Lys Lys Val Arg Lys Tyr Trp Asp Val Pro Pro 
                85                  90                  95      


Pro Gly Phe Glu His Ile Thr Pro Met Gln Tyr Lys Ala Met Gln Ala 
            100                 105                 110         


Ala Gly Gln Ile Pro Ala Thr Ala Leu Leu Pro Thr Met Thr Pro Asp 
        115                 120                 125             


Gly Leu Ala Val Thr Pro Thr Pro Val Pro Val Val Gly Ser Gln Met 
    130                 135                 140                 


Thr Arg Gln Ala Arg Arg Leu Tyr Val Gly Asn Ile Pro Phe Gly Ile 
145                 150                 155                 160 


Thr Glu Glu Ala Met Met Asp Phe Phe Asn Ala Gln Met Arg Leu Gly 
                165                 170                 175     


Gly Leu Thr Gln Ala Pro Gly Asn Pro Val Leu Ala Val Gln Ile Asn 
            180                 185                 190         


Gln Asp Lys Asn Phe Ala Phe Leu Glu Phe Arg Ser Val Asp Glu Thr 
        195                 200                 205             


Thr Gln Ala Met Ala Phe Asp Gly Ile Ile Phe Gln Gly Gln Ser Leu 
    210                 215                 220                 


Lys Ile Arg Arg Pro His Asp Tyr Gln Pro Leu Pro Gly Met Ser Glu 
225                 230                 235                 240 


Asn Pro Ser Val Tyr Val Pro Gly Val Val Ser Thr Val Val Pro Asp 
                245                 250                 255     


Ser Ala His Lys Leu Phe Ile Gly Gly Leu Pro Asn Tyr Leu Asn Asp 
            260                 265                 270         


Asp Gln Val Lys Glu Leu Leu Thr Ser Phe Gly Pro Leu Lys Ala Phe 
        275                 280                 285             


Asn Leu Val Lys Asp Ser Ala Thr Gly Leu Ser Lys Gly Tyr Ala Phe 
    290                 295                 300                 


Cys Glu Tyr Val Asp Ile Asn Val Thr Asp Gln Ala Ile Ala Gly Leu 
305                 310                 315                 320 


Asn Gly Met Gln Leu Gly Asp Lys Lys Leu Leu Val Gln Arg Ala Ser 
                325                 330                 335     


Val Gly Ala Lys Asn Ala Thr Leu Val Ser Pro Pro Ser Thr Ile Asn 
            340                 345                 350         


Gln Thr Pro Val Thr Leu Gln Val Pro Gly Leu Met Ser Ser Gln Val 
        355                 360                 365             


Gln Met Gly Gly His Pro Thr Glu Val Leu Cys Leu Met Asn Met Val 
    370                 375                 380                 


Leu Pro Glu Glu Leu Leu Asp Asp Glu Glu Tyr Glu Glu Ile Val Glu 
385                 390                 395                 400 


Asp Val Arg Asp Glu Cys Ser Lys Tyr Gly Leu Val Lys Ser Ile Glu 
                405                 410                 415     


Ile Pro Arg Pro Val Asp Gly Val Glu Val Pro Gly Cys Gly Lys Ile 
            420                 425                 430         


Phe Val Glu Phe Thr Ser Val Phe Asp Cys Gln Lys Ala Met Gln Gly 
        435                 440                 445             


Leu Thr Gly Arg Lys Phe Ala Asn Arg Val Val Val Thr Lys Tyr Cys 
    450                 455                 460                 


Asp Pro Asp Ser Tyr His Arg Arg Asp Phe Trp 
465                 470                 475 


<210>  226
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ala Ala Asn Ala Thr Thr Asn Pro Ser Gln Leu Leu Pro Leu Glu 
1               5                   10                  15      


Leu Val Asp Lys Cys Ile Gly Ser Arg Ile His Ile Val Met Lys Ser 
            20                  25                  30          


Asp Lys Glu Ile Val Gly Thr Leu Leu Gly Phe Asp Asp Phe Val Asn 
        35                  40                  45              


Met Val Leu Glu Asp Val Thr Glu Phe Glu Ile Thr Pro Glu Gly Arg 
    50                  55                  60                  


Arg Ile Thr Lys Leu Asp Gln Ile Leu Leu Asn Gly Asn Asn Ile Thr 
65                  70                  75                  80  


Met Leu Val Pro Gly Gly Glu Gly Pro Glu Val 
                85                  90      


<210>  227
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Ser Ser Ser Pro Val Asn Val Lys Lys Leu Lys Val Ser Glu Leu 
1               5                   10                  15      


Lys Glu Glu Leu Lys Lys Arg Arg Leu Ser Asp Lys Gly Leu Lys Ala 
            20                  25                  30          


Glu Leu Met Glu Arg Leu Gln Ala Ala Leu Asp Asp Glu Glu Ala Gly 
        35                  40                  45              


Gly Arg Pro Ala Met Glu Pro Gly Asn Gly Ser Leu Asp Leu Gly Gly 
    50                  55                  60                  


Asp Ser Ala Gly Arg Ser Gly Ala Gly Leu Glu Gln Glu Ala Ala Ala 
65                  70                  75                  80  


Gly Gly Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ile 
                85                  90                  95      


Ser Ala Leu Asp Gly Asp Gln Met Glu Leu Gly Glu Glu Asn Gly Ala 
            100                 105                 110         


Ala Gly Ala Ala Asp Ser Gly Pro Met Glu Glu Glu Glu Ala Ala Ser 
        115                 120                 125             


Glu Asp Glu Asn Gly Asp Asp Gln Gly Phe Gln Glu Gly Glu Asp Glu 
    130                 135                 140                 


Leu Gly Asp Glu Glu Glu Gly Ala Gly Asp Glu Asn Gly His Gly Glu 
145                 150                 155                 160 


Gln Gln Pro Gln Pro Pro Ala Thr Gln Gln Gln Gln Pro Gln Gln Gln 
                165                 170                 175     


Arg Gly Ala Ala Lys Glu Ala Ala Gly Lys Ser Ser Gly Pro Thr Ser 
            180                 185                 190         


Leu Phe Ala Val Thr Val Ala Pro Pro Gly Ala Arg Gln Gly Gln Gln 
        195                 200                 205             


Gln Ala Gly Gly Lys Lys Lys Ala Glu Gly Gly Gly Gly Gly Gly Arg 
    210                 215                 220                 


Pro Gly Ala Pro Ala Ala Gly Asp Gly Lys Thr Glu Gln Lys Gly Gly 
225                 230                 235                 240 


Asp Lys Lys Arg Gly Val Lys Arg Pro Arg Glu Asp His Gly Arg Gly 
                245                 250                 255     


Tyr Phe Glu Tyr Ile Glu Glu Asn Lys Tyr Ser Arg Ala Lys Ser Pro 
            260                 265                 270         


Gln Pro Pro Val Glu Glu Glu Asp Glu His Phe Asp Asp Thr Val Val 
        275                 280                 285             


Cys Leu Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Ile Ser Arg Asp 
    290                 295                 300                 


Arg Leu Ser Ala Ser Ser Leu Thr Met Glu Ser Phe Ala Phe Leu Trp 
305                 310                 315                 320 


Ala Gly Gly Arg Ala Ser Tyr Gly Val Ser Lys Gly Lys Val Cys Phe 
                325                 330                 335     


Glu Met Lys Val Thr Glu Lys Ile Pro Val Arg His Leu Tyr Thr Lys 
            340                 345                 350         


Asp Ile Asp Ile His Glu Val Arg Ile Gly Trp Ser Leu Thr Thr Ser 
        355                 360                 365             


Gly Met Leu Leu Gly Glu Glu Glu Phe Ser Tyr Gly Tyr Ser Leu Lys 
    370                 375                 380                 


Gly Ile Lys Thr Cys Asn Cys Glu Thr Glu Asp Tyr Gly Glu Lys Phe 
385                 390                 395                 400 


Asp Glu Asn Asp Val Ile Thr Cys Phe Ala Asn Phe Glu Ser Asp Glu 
                405                 410                 415     


Val Glu Leu Ser Tyr Ala Lys Asn Gly Gln Asp Leu Gly Val Ala Phe 
            420                 425                 430         


Lys Ile Ser Lys Glu Val Leu Ala Gly Arg Pro Leu Phe Pro His Val 
        435                 440                 445             


Leu Cys His Asn Cys Ala Val Glu Phe Asn Phe Gly Gln Lys Glu Lys 
    450                 455                 460                 


Pro Tyr Phe Pro Ile Pro Glu Glu Tyr Thr Phe Ile Gln Asn Val Pro 
465                 470                 475                 480 


Leu Glu Asp Arg Val Arg Gly Pro Lys Gly Pro Glu Glu Lys Lys Asp 
                485                 490                 495     


Cys Glu Val Val Met Met Ile Gly Leu Pro Gly Ala Gly Lys Thr Thr 
            500                 505                 510         


Trp Val Thr Lys His Ala Ala Glu Asn Pro Gly Lys Tyr Asn Ile Leu 
        515                 520                 525             


Gly Thr Asn Thr Ile Met Asp Lys Met Met Val Ala Gly Phe Lys Lys 
    530                 535                 540                 


Gln Met Ala Asp Thr Gly Lys Leu Asn Thr Leu Leu Gln Arg Ala Pro 
545                 550                 555                 560 


Gln Cys Leu Gly Lys Phe Ile Glu Ile Ala Ala Arg Lys Lys Arg Asn 
                565                 570                 575     


Phe Ile Leu Asp Gln Thr Asn Val Ser Ala Ala Ala Gln Arg Arg Lys 
            580                 585                 590         


Met Cys Leu Phe Ala Gly Phe Gln Arg Lys Ala Val Val Val Cys Pro 
        595                 600                 605             


Lys Asp Glu Asp Tyr Lys Gln Arg Thr Gln Lys Lys Ala Glu Val Glu 
    610                 615                 620                 


Gly Lys Asp Leu Pro Glu His Ala Val Leu Lys Met Lys Gly Asn Phe 
625                 630                 635                 640 


Thr Leu Pro Glu Val Ala Glu Cys Phe Asp Glu Ile Thr Tyr Val Glu 
                645                 650                 655     


Leu Gln Lys Glu Glu Ala Gln Lys Leu Leu Glu Gln Tyr Lys Glu Glu 
            660                 665                 670         


Ser Lys Lys Ala Leu Pro Pro Glu Lys Lys Gln Asn Thr Gly Ser Lys 
        675                 680                 685             


Lys Ser Asn Lys Asn Lys Ser Gly Lys Asn Gln Phe Asn Arg Gly Gly 
    690                 695                 700                 


Gly His Arg Gly Arg Gly Gly Phe Asn Met Arg Gly Gly Asn Phe Arg 
705                 710                 715                 720 


Gly Gly Ala Pro Gly Asn Arg Gly Gly Tyr Asn Arg Arg Gly Asn Met 
                725                 730                 735     


Pro Gln Arg Gly Gly Gly Gly Gly Gly Ser Gly Gly Ile Gly Tyr Pro 
            740                 745                 750         


Tyr Pro Arg Ala Pro Val Phe Pro Gly Arg Gly Ser Tyr Ser Asn Arg 
        755                 760                 765             


Gly Asn Tyr Asn Arg Gly Gly Met Pro Asn Arg Gly Asn Tyr Asn Gln 
    770                 775                 780                 


Asn Phe Arg Gly Arg Gly Asn Asn Arg Gly Tyr Lys Asn Gln Ser Gln 
785                 790                 795                 800 


Gly Tyr Asn Gln Trp Gln Gln Gly Gln Phe Trp Gly Gln Lys Pro Trp 
                805                 810                 815     


Ser Gln His Tyr His Gln Gly Tyr Tyr 
            820                 825 


<210>  228
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210>  229
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Leu Arg Lys Glu Glu Leu Asn Ala Ile Ser Gly Pro Asn Glu 
65                  70                  75                  80  


Phe Ala Glu Phe Tyr Asn Arg Leu Lys Gln Ile Lys Glu Phe His Arg 
                85                  90                  95      


Lys His Pro Asn Glu Ile Cys Val Pro Met Ser Val Glu Phe Glu Glu 
            100                 105                 110         


Leu Leu Lys Ala Arg Glu Asn Pro Ser Glu Glu Ala Gln Asn Leu Val 
        115                 120                 125             


Glu Phe Thr Asp Glu Glu Gly Tyr Gly Arg Tyr Leu Asp Leu His Asp 
    130                 135                 140                 


Cys Tyr Leu Lys Tyr Ile Asn Leu Lys Ala Ser Glu Lys Leu Asp Tyr 
145                 150                 155                 160 


Ile Thr Tyr Leu Ser Ile Phe Asp Gln Leu Phe Asp Ile Pro Lys Glu 
                165                 170                 175     


Arg Lys Asn Ala Glu Tyr Lys Arg Tyr Leu Glu Met Leu Leu Glu Tyr 
            180                 185                 190         


Leu Gln Asp Tyr Thr Asp Arg Val Lys Pro Leu Gln Asp Gln Asn Glu 
        195                 200                 205             


Leu Phe Gly Lys Ile Gln Ala Glu Phe Glu Lys Lys Trp Glu Asn Gly 
    210                 215                 220                 


Thr Phe Pro Gly Trp Pro Lys Glu Thr Ser Ser Ala Leu Thr His Ala 
225                 230                 235                 240 


Gly Ala His Leu Asp Leu Ser Ala Phe Ser Ser Trp Glu Glu Leu Ala 
                245                 250                 255     


Ser Leu Gly Leu Asp Arg Leu Lys Ser Ala Leu Leu Ala Leu Gly Leu 
            260                 265                 270         


Lys Cys Gly Gly Thr Leu Glu Glu Arg Ala Gln Arg Leu Phe Ser Thr 
        275                 280                 285             


Lys Gly Lys Ser Leu Glu Ser Leu Asp Thr Ser Leu Phe Ala Lys Asn 
    290                 295                 300                 


Pro Lys Ser Lys Gly Thr Lys Arg Asp Thr Glu Arg Asn Lys Asp Ile 
305                 310                 315                 320 


Ala Phe Leu Glu Ala Gln Ile Tyr Glu Tyr Val Glu Ile Leu Gly Glu 
                325                 330                 335     


Gln Arg His Leu Thr His Glu Asn Val Gln Arg Lys Gln Ala Arg Thr 
            340                 345                 350         


Gly Glu Glu Arg Glu Glu Glu Glu Glu Glu Gln Ile Ser Glu Ser Glu 
        355                 360                 365             


Ser Glu Asp Glu Glu Asn Glu Ile Ile Tyr Asn Pro Lys Asn Leu Pro 
    370                 375                 380                 


Leu Gly Trp Asp Gly Lys Pro Ile Pro Tyr Trp Leu Tyr Lys Leu His 
385                 390                 395                 400 


Gly Leu Asn Ile Asn Tyr Asn Cys Glu Ile Cys Gly Asn Tyr Thr Tyr 
                405                 410                 415     


Arg Gly Pro Lys Ala Phe Gln Arg His Phe Ala Glu Trp Arg His Ala 
            420                 425                 430         


His Gly Met Arg Cys Leu Gly Ile Pro Asn Thr Ala His Phe Ala Asn 
        435                 440                 445             


Val Thr Gln Ile Glu Asp Ala Val Ser Leu Trp Ala Lys Leu Lys Leu 
    450                 455                 460                 


Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp Thr Glu Glu Glu Tyr Glu 
465                 470                 475                 480 


Asp Ser Ser Gly Asn Val Val Asn Lys Lys Thr Tyr Glu Asp Leu Lys 
                485                 490                 495     


Arg Gln Gly Leu Leu 
            500     


<210>  230
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  230

Met His Arg Asp Ser Cys Pro Leu Asp Cys Lys Val Tyr Val Gly Asn 
1               5                   10                  15      


Leu Gly Asn Asn Gly Asn Lys Thr Glu Leu Glu Arg Ala Phe Gly Tyr 
            20                  25                  30          


Tyr Gly Pro Leu Arg Ser Val Trp Val Ala Arg Asn Pro Pro Gly Phe 
        35                  40                  45              


Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Ala Asp Ala Val Arg 
    50                  55                  60                  


Glu Leu Asp Gly Arg Thr Leu Cys Gly Cys Arg Val Arg Val Glu Leu 
65                  70                  75                  80  


Ser Asn Gly Glu Lys Arg Ser Arg Asn Arg Gly Pro Pro Pro Ser Trp 
                85                  90                  95      


Gly Arg Arg Pro Arg Asp Asp Tyr Arg Arg Arg Ser Pro Pro Pro Arg 
            100                 105                 110         


Arg Arg Ser Pro Arg Arg Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser 
        115                 120                 125             


Leu Ser Arg Asp Arg Arg Arg Glu Arg Ser Leu Ser Arg Glu Arg Asn 
    130                 135                 140                 


His Lys Pro Ser Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser Arg Ser 
145                 150                 155                 160 


Asn Glu Arg Lys 
                


<210>  231
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Ser Arg Tyr Gly Arg Tyr Gly Gly Glu Thr Lys Val Tyr Val Gly 
1               5                   10                  15      


Asn Leu Gly Thr Gly Ala Gly Lys Gly Glu Leu Glu Arg Ala Phe Ser 
            20                  25                  30          


Tyr Tyr Gly Pro Leu Arg Thr Val Trp Ile Ala Arg Asn Pro Pro Gly 
        35                  40                  45              


Phe Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Glu Asp Ala Val 
    50                  55                  60                  


Arg Gly Leu Asp Gly Lys Val Ile Cys Gly Ser Arg Val Arg Val Glu 
65                  70                  75                  80  


Leu Ser Thr Gly Met Pro Arg Arg Ser Arg Phe Asp Arg Pro Pro Ala 
                85                  90                  95      


Arg Arg Pro Phe Asp Pro Asn Asp Arg Cys Tyr Glu Cys Gly Glu Lys 
            100                 105                 110         


Gly His Tyr Ala Tyr Asp Cys His Arg Tyr Ser Arg Arg Arg Arg Ser 
        115                 120                 125             


Arg Ser Arg Ser Arg Ser His Ser Arg Ser Arg Gly Arg Arg Tyr Ser 
    130                 135                 140                 


Arg Ser Arg Ser Arg Ser Arg Gly Arg Arg Ser Arg Ser Ala Ser Pro 
145                 150                 155                 160 


Arg Arg Ser Arg Ser Ile Ser Leu Arg Arg Ser Arg Ser Ala Ser Leu 
                165                 170                 175     


Arg Arg Ser Arg Ser Gly Ser Ile Lys Gly Ser Arg Tyr Phe Gln Ser 
            180                 185                 190         


Pro Ser Arg Ser Arg Ser Arg Ser Arg Ser Ile Ser Arg Pro Arg Ser 
        195                 200                 205             


Ser Arg Ser Lys Ser Arg Ser Pro Ser Pro Lys Arg Ser Arg Ser Pro 
    210                 215                 220                 


Ser Gly Ser Pro Arg Arg Ser Ala Ser Pro Glu Arg Met Asp 
225                 230                 235             


<210>  232
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Ser Asp Ser Gly Glu Gln Asn Tyr Gly Glu Arg Glu Ser Arg Ser 
1               5                   10                  15      


Ala Ser Arg Ser Gly Ser Ala His Gly Ser Gly Lys Ser Ala Arg His 
            20                  25                  30          


Thr Pro Ala Arg Ser Arg Ser Lys Glu Asp Ser Arg Arg Ser Arg Ser 
        35                  40                  45              


Lys Ser Arg Ser Arg Ser Glu Ser Arg Ser Arg Ser Arg Arg Ser Ser 
    50                  55                  60                  


Arg Arg His Tyr Thr Arg Ser Arg Ser Arg Ser Arg Ser His Arg Arg 
65                  70                  75                  80  


Ser Arg Ser Arg Ser Tyr Ser Arg Asp Tyr Arg Arg Arg His Ser His 
                85                  90                  95      


Ser His Ser Pro Met Ser Thr Arg Arg Arg His Val Gly Asn Arg Ala 
            100                 105                 110         


Asn Pro Asp Pro Asn Cys Cys Leu Gly Val Phe Gly Leu Ser Leu Tyr 
        115                 120                 125             


Thr Thr Glu Arg Asp Leu Arg Glu Val Phe Ser Lys Tyr Gly Pro Ile 
    130                 135                 140                 


Ala Asp Val Ser Ile Val Tyr Asp Gln Gln Ser Arg Arg Ser Arg Gly 
145                 150                 155                 160 


Phe Ala Phe Val Tyr Phe Glu Asn Val Asp Asp Ala Lys Glu Ala Lys 
                165                 170                 175     


Glu Arg Ala Asn Gly Met Glu Leu Asp Gly Arg Arg Ile Arg Val Asp 
            180                 185                 190         


Phe Ser Ile Thr Lys Arg Pro His Thr Pro Thr Pro Gly Ile Tyr Met 
        195                 200                 205             


Gly Arg Pro Thr Tyr Gly Ser Ser Arg Arg Arg Asp Tyr Tyr Asp Arg 
    210                 215                 220                 


Gly Tyr Asp Arg Gly Tyr Asp Asp Arg Asp Tyr Tyr Ser Arg Ser Tyr 
225                 230                 235                 240 


Arg Gly Gly Gly Gly Gly Gly Gly Gly Trp Arg Ala Ala Gln Asp Arg 
                245                 250                 255     


Asp Gln Ile Tyr Arg Arg Arg Ser Pro Ser Pro Tyr Tyr Ser Arg Gly 
            260                 265                 270         


Gly Tyr Arg Ser Arg Ser Arg Ser Arg Ser Tyr Ser Pro Arg Arg Tyr 
        275                 280                 285             


<210>  233
<211>  2335
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210>  234
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Ser Leu Pro Leu Asn Pro Lys Pro Phe Leu Asn Gly Leu Thr Gly 
1               5                   10                  15      


Lys Pro Val Met Val Lys Leu Lys Trp Gly Met Glu Tyr Lys Gly Tyr 
            20                  25                  30          


Leu Val Ser Val Asp Gly Tyr Met Asn Met Gln Leu Ala Asn Thr Glu 
        35                  40                  45              


Glu Tyr Ile Asp Gly Ala Leu Ser Gly His Leu Gly Glu Val Leu Ile 
    50                  55                  60                  


Arg Cys Asn Asn Val Leu Tyr Ile Arg Gly Val Glu Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Gly Glu Met Arg Glu 
                85      


<210>  235
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Val Lys Leu Thr Ala Glu Leu Ile Glu Gln Ala Ala Gln Tyr Thr 
1               5                   10                  15      


Asn Ala Val Arg Asp Arg Glu Leu Asp Leu Arg Gly Tyr Lys Ile Pro 
            20                  25                  30          


Val Ile Glu Asn Leu Gly Ala Thr Leu Asp Gln Phe Asp Ala Ile Asp 
        35                  40                  45              


Phe Ser Asp Asn Glu Ile Arg Lys Leu Asp Gly Phe Pro Leu Leu Arg 
    50                  55                  60                  


Arg Leu Lys Thr Leu Leu Val Asn Asn Asn Arg Ile Cys Arg Ile Gly 
65                  70                  75                  80  


Glu Gly Leu Asp Gln Ala Leu Pro Cys Leu Thr Glu Leu Ile Leu Thr 
                85                  90                  95      


Asn Asn Ser Leu Val Glu Leu Gly Asp Leu Asp Pro Leu Ala Ser Leu 
            100                 105                 110         


Lys Ser Leu Thr Tyr Leu Ser Ile Leu Arg Asn Pro Val Thr Asn Lys 
        115                 120                 125             


Lys His Tyr Arg Leu Tyr Val Ile Tyr Lys Val Pro Gln Val Arg Val 
    130                 135                 140                 


Leu Asp Phe Gln Lys Val Lys Leu Lys Glu Arg Gln Glu Ala Glu Lys 
145                 150                 155                 160 


Met Phe Lys Gly Lys Arg Gly Ala Gln Leu Ala Lys Asp Ile Ala Arg 
                165                 170                 175     


Arg Ser Lys Thr Phe Asn Pro Gly Ala Gly Leu Pro Thr Asp Lys Lys 
            180                 185                 190         


Lys Gly Gly Pro Ser Pro Gly Asp Val Glu Ala Ile Lys Asn Ala Ile 
        195                 200                 205             


Ala Asn Ala Ser Thr Leu Ala Glu Val Glu Arg Leu Lys Gly Leu Leu 
    210                 215                 220                 


Gln Ser Gly Gln Ile Pro Gly Arg Glu Arg Arg Ser Gly Pro Thr Asp 
225                 230                 235                 240 


Asp Gly Glu Glu Glu Met Glu Glu Asp Thr Val Thr Asn Gly Ser 
                245                 250                 255 


<210>  236
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Ser Leu Leu Asn Lys Pro Lys Ser Glu Met Thr Pro Glu Glu Leu 
1               5                   10                  15      


Gln Lys Arg Glu Glu Glu Glu Phe Asn Thr Gly Pro Leu Ser Val Leu 
            20                  25                  30          


Thr Gln Ser Val Lys Asn Asn Thr Gln Val Leu Ile Asn Cys Arg Asn 
        35                  40                  45              


Asn Lys Lys Leu Leu Gly Arg Val Lys Ala Phe Asp Arg His Cys Asn 
    50                  55                  60                  


Met Val Leu Glu Asn Val Lys Glu Met Trp Thr Glu Val Pro Lys Ser 
65                  70                  75                  80  


Gly Lys Gly Lys Lys Lys Ser Lys Pro Val Asn Lys Asp Arg Tyr Ile 
                85                  90                  95      


Ser Lys Met Phe Leu Arg Gly Asp Ser Val Ile Val Val Leu Arg Asn 
            100                 105                 110         


Pro Leu Ile Ala Gly Lys 
        115             


<210>  237
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ala Asp Lys Glu Lys Lys Lys Lys Glu Ser Ile Leu Asp Leu Ser 
1               5                   10                  15      


Lys Tyr Ile Asp Lys Thr Ile Arg Val Lys Phe Gln Gly Gly Arg Glu 
            20                  25                  30          


Ala Ser Gly Ile Leu Lys Gly Phe Asp Pro Leu Leu Asn Leu Val Leu 
        35                  40                  45              


Asp Gly Thr Ile Glu Tyr Met Arg Asp Pro Asp Asp Gln Tyr Lys Leu 
    50                  55                  60                  


Thr Glu Asp Thr Arg Gln Leu Gly Leu Val Val Cys Arg Gly Thr Ser 
65                  70                  75                  80  


Val Val Leu Ile Cys Pro Gln Asp Gly Met Glu Ala Ile Pro Asn Pro 
                85                  90                  95      


Phe Ile Gln Gln Gln Asp Ala 
            100             


<210>  238
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Asp Phe Gln His Arg Pro Gly Gly Lys Thr Gly Ser Gly Gly Val 
1               5                   10                  15      


Ala Ser Ser Ser Glu Ser Asn Arg Asp Arg Arg Glu Arg Leu Arg Gln 
            20                  25                  30          


Leu Ala Leu Glu Thr Ile Asp Ile Asn Lys Asp Pro Tyr Phe Met Lys 
        35                  40                  45              


Asn His Leu Gly Ser Tyr Glu Cys Lys Leu Cys Leu Thr Leu His Asn 
    50                  55                  60                  


Asn Glu Gly Ser Tyr Leu Ala His Thr Gln Gly Lys Lys His Gln Thr 
65                  70                  75                  80  


Asn Leu Ala Arg Arg Ala Ala Lys Glu Ala Lys Glu Ala Pro Ala Gln 
                85                  90                  95      


Pro Ala Pro Glu Lys Val Lys Val Glu Val Lys Lys Phe Val Lys Ile 
            100                 105                 110         


Gly Arg Pro Gly Tyr Lys Val Thr Lys Gln Arg Asp Ser Glu Met Gly 
        115                 120                 125             


Gln Gln Ser Leu Leu Phe Gln Ile Asp Tyr Pro Glu Ile Ala Glu Gly 
    130                 135                 140                 


Ile Met Pro Arg His Arg Phe Met Ser Ala Tyr Glu Gln Arg Ile Glu 
145                 150                 155                 160 


Pro Pro Asp Arg Arg Trp Gln Tyr Leu Leu Met Ala Ala Glu Pro Tyr 
                165                 170                 175     


Glu Thr Ile Ala Phe Lys Val Pro Ser Arg Glu Ile Asp Lys Ala Glu 
            180                 185                 190         


Gly Lys Phe Trp Thr His Trp Asn Arg Glu Thr Lys Gln Phe Phe Leu 
        195                 200                 205             


Gln Phe His Phe Lys Met Glu Lys Pro Pro Ala Pro Pro Ser Leu Pro 
    210                 215                 220                 


Ala Gly Pro Pro Gly Val Lys Arg Pro Pro Pro Pro Leu Met Asn Gly 
225                 230                 235                 240 


Leu Pro Pro Arg Pro Pro Leu Pro Glu Ser Leu Pro Pro Pro Pro Pro 
                245                 250                 255     


Gly Gly Leu Pro Leu Pro Pro Met Pro Pro Thr Gly Pro Ala Pro Ser 
            260                 265                 270         


Gly Pro Pro Gly Pro Pro Gln Leu Pro Pro Pro Ala Pro Gly Val His 
        275                 280                 285             


Pro Pro Ala Pro Val Val His Pro Pro Ala Ser Gly Val His Pro Pro 
    290                 295                 300                 


Ala Pro Gly Val His Pro Pro Ala Pro Gly Val His Pro Pro Ala Pro 
305                 310                 315                 320 


Gly Val His Pro Pro Thr Ser Gly Val His Pro Pro Ala Pro Gly Val 
                325                 330                 335     


His Pro Pro Ala Pro Gly Val His Pro Pro Ala Pro Gly Val His Pro 
            340                 345                 350         


Pro Ala Pro Gly Val His Pro Pro Ala Pro Gly Val His Pro Pro Pro 
        355                 360                 365             


Ser Ala Gly Val His Pro Gln Ala Pro Gly Val His Pro Ala Ala Pro 
    370                 375                 380                 


Ala Val His Pro Gln Ala Pro Gly Val His Pro Pro Ala Pro Gly Met 
385                 390                 395                 400 


His Pro Gln Ala Pro Gly Val His Pro Gln Pro Pro Gly Val His Pro 
                405                 410                 415     


Ser Ala Pro Gly Val His Pro Gln Pro Pro Gly Val His Pro Ser Asn 
            420                 425                 430         


Pro Gly Val His Pro Pro Thr Pro Met Pro Pro Met Leu Arg Pro Pro 
        435                 440                 445             


Leu Pro Ser Glu Gly Pro Gly Asn Ile Pro Pro Pro Pro Pro Thr Asn 
    450                 455                 460                 


<210>  239
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Thr Asp Arg Tyr Thr Ile His Ser Gln Leu Glu His Leu Gln Ser 
1               5                   10                  15      


Lys Tyr Ile Gly Thr Gly His Ala Asp Thr Thr Lys Trp Glu Trp Leu 
            20                  25                  30          


Val Asn Gln His Arg Asp Ser Tyr Cys Ser Tyr Met Gly His Phe Asp 
        35                  40                  45              


Leu Leu Asn Tyr Phe Ala Ile Ala Glu Asn Glu Ser Lys Ala Arg Val 
    50                  55                  60                  


Arg Phe Asn Leu Met Glu Lys Met Leu Gln Pro Cys Gly Pro Pro Ala 
65                  70                  75                  80  


Asp Lys Pro Glu Glu Asn 
                85      


<210>  240
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  241
<211>  1001
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ile Phe Pro Val Ala Arg Tyr Ala Leu Arg Trp Leu Arg Arg Pro 
1               5                   10                  15      


Glu Asp Arg Ala Phe Ser Arg Ala Ala Met Glu Met Ala Leu Arg Gly 
            20                  25                  30          


Val Arg Lys Val Leu Cys Val Ala Glu Lys Asn Asp Ala Ala Lys Gly 
        35                  40                  45              


Ile Ala Asp Leu Leu Ser Asn Gly Arg Met Arg Arg Arg Glu Gly Leu 
    50                  55                  60                  


Ser Lys Phe Asn Lys Ile Tyr Glu Phe Asp Tyr His Leu Tyr Gly Gln 
65                  70                  75                  80  


Asn Val Thr Met Val Met Thr Ser Val Ser Gly His Leu Leu Ala His 
                85                  90                  95      


Asp Phe Gln Met Gln Phe Arg Lys Trp Gln Ser Cys Asn Pro Leu Val 
            100                 105                 110         


Leu Phe Glu Ala Glu Ile Glu Lys Tyr Cys Pro Glu Asn Phe Val Asp 
        115                 120                 125             


Ile Lys Lys Thr Leu Glu Arg Glu Thr Arg Gln Cys Gln Ala Leu Val 
    130                 135                 140                 


Ile Trp Thr Asp Cys Asp Arg Glu Gly Glu Asn Ile Gly Phe Glu Ile 
145                 150                 155                 160 


Ile His Val Cys Lys Ala Val Lys Pro Asn Leu Gln Val Leu Arg Ala 
                165                 170                 175     


Arg Phe Ser Glu Ile Thr Pro His Ala Val Arg Thr Ala Cys Glu Asn 
            180                 185                 190         


Leu Thr Glu Pro Asp Gln Arg Val Ser Asp Ala Val Asp Val Arg Gln 
        195                 200                 205             


Glu Leu Asp Leu Arg Ile Gly Ala Ala Phe Thr Arg Phe Gln Thr Leu 
    210                 215                 220                 


Arg Leu Gln Arg Ile Phe Pro Glu Val Leu Ala Glu Gln Leu Ile Ser 
225                 230                 235                 240 


Tyr Gly Ser Cys Gln Phe Pro Thr Leu Gly Phe Val Val Glu Arg Phe 
                245                 250                 255     


Lys Ala Ile Gln Ala Phe Val Pro Glu Ile Phe His Arg Ile Lys Val 
            260                 265                 270         


Thr His Asp His Lys Asp Gly Ile Val Glu Phe Asn Trp Lys Arg His 
        275                 280                 285             


Arg Leu Phe Asn His Thr Ala Cys Leu Val Leu Tyr Gln Leu Cys Val 
    290                 295                 300                 


Glu Asp Pro Met Ala Thr Val Val Glu Val Arg Ser Lys Pro Lys Ser 
305                 310                 315                 320 


Lys Trp Arg Pro Gln Ala Leu Asp Thr Val Glu Leu Glu Lys Leu Ala 
                325                 330                 335     


Ser Arg Lys Leu Arg Ile Asn Ala Lys Glu Thr Met Arg Ile Ala Glu 
            340                 345                 350         


Lys Leu Tyr Thr Gln Gly Tyr Ile Ser Tyr Pro Arg Thr Glu Thr Asn 
        355                 360                 365             


Ile Phe Pro Arg Asp Leu Asn Leu Thr Val Leu Val Glu Gln Gln Thr 
    370                 375                 380                 


Pro Asp Pro Arg Trp Gly Ala Phe Ala Gln Ser Ile Leu Glu Arg Gly 
385                 390                 395                 400 


Gly Pro Thr Pro Arg Asn Gly Asn Lys Ser Asp Gln Ala His Pro Pro 
                405                 410                 415     


Ile His Pro Thr Lys Tyr Thr Asn Asn Leu Gln Gly Asp Glu Gln Arg 
            420                 425                 430         


Leu Tyr Glu Phe Ile Val Arg His Phe Leu Ala Cys Cys Ser Gln Asp 
        435                 440                 445             


Ala Gln Gly Gln Glu Thr Thr Val Glu Ile Asp Ile Ala Gln Glu Arg 
    450                 455                 460                 


Phe Val Ala His Gly Leu Met Ile Leu Ala Arg Asn Tyr Leu Asp Val 
465                 470                 475                 480 


Tyr Pro Tyr Asp His Trp Ser Asp Lys Ile Leu Pro Val Tyr Glu Gln 
                485                 490                 495     


Gly Ser His Phe Gln Pro Ser Thr Val Glu Met Val Asp Gly Glu Thr 
            500                 505                 510         


Ser Pro Pro Lys Leu Leu Thr Glu Ala Asp Leu Ile Ala Leu Met Glu 
        515                 520                 525             


Lys His Gly Ile Gly Thr Asp Ala Thr His Ala Glu His Ile Glu Thr 
    530                 535                 540                 


Ile Lys Ala Arg Met Tyr Val Gly Leu Thr Pro Asp Lys Arg Phe Leu 
545                 550                 555                 560 


Pro Gly His Leu Gly Met Gly Leu Val Glu Gly Tyr Asp Ser Met Gly 
                565                 570                 575     


Tyr Glu Met Ser Lys Pro Asp Leu Arg Ala Glu Leu Glu Ala Asp Leu 
            580                 585                 590         


Lys Leu Ile Cys Asp Gly Lys Lys Asp Lys Phe Val Val Leu Arg Gln 
        595                 600                 605             


Gln Val Gln Lys Tyr Lys Gln Val Phe Ile Glu Ala Val Ala Lys Ala 
    610                 615                 620                 


Lys Lys Leu Asp Glu Ala Leu Ala Gln Tyr Phe Gly Asn Gly Thr Glu 
625                 630                 635                 640 


Leu Ala Gln Gln Glu Asp Ile Tyr Pro Ala Met Pro Glu Pro Ile Arg 
                645                 650                 655     


Lys Cys Pro Gln Cys Asn Lys Asp Met Val Leu Lys Thr Lys Lys Asn 
            660                 665                 670         


Gly Gly Phe Tyr Leu Ser Cys Met Gly Phe Pro Glu Cys Arg Ser Ala 
        675                 680                 685             


Val Trp Leu Pro Asp Ser Val Leu Glu Ala Ser Arg Asp Ser Ser Val 
    690                 695                 700                 


Cys Pro Val Cys Gln Pro His Pro Val Tyr Arg Leu Lys Leu Lys Phe 
705                 710                 715                 720 


Lys Arg Gly Ser Leu Pro Pro Thr Met Pro Leu Glu Phe Val Cys Cys 
                725                 730                 735     


Ile Gly Gly Cys Asp Asp Thr Leu Arg Glu Ile Leu Asp Leu Arg Phe 
            740                 745                 750         


Ser Gly Gly Pro Pro Arg Ala Ser Gln Pro Ser Gly Arg Leu Gln Ala 
        755                 760                 765             


Asn Gln Ser Leu Asn Arg Met Asp Asn Ser Gln His Pro Gln Pro Ala 
    770                 775                 780                 


Asp Ser Arg Gln Thr Gly Ser Ser Lys Ala Leu Ala Gln Thr Leu Pro 
785                 790                 795                 800 


Pro Pro Thr Ala Ala Gly Glu Ser Asn Ser Val Thr Cys Asn Cys Gly 
                805                 810                 815     


Gln Glu Ala Val Leu Leu Thr Val Arg Lys Glu Gly Pro Asn Arg Gly 
            820                 825                 830         


Arg Gln Phe Phe Lys Cys Asn Gly Gly Ser Cys Asn Phe Phe Leu Trp 
        835                 840                 845             


Ala Asp Ser Pro Asn Pro Gly Ala Gly Gly Pro Pro Ala Leu Ala Tyr 
    850                 855                 860                 


Arg Pro Leu Gly Ala Ser Leu Gly Cys Pro Pro Gly Pro Gly Ile His 
865                 870                 875                 880 


Leu Gly Gly Phe Gly Asn Pro Gly Asp Gly Ser Gly Ser Gly Thr Ser 
                885                 890                 895     


Cys Leu Cys Ser Gln Pro Ser Val Thr Arg Thr Val Gln Lys Asp Gly 
            900                 905                 910         


Pro Asn Lys Gly Arg Gln Phe His Thr Cys Ala Lys Pro Arg Glu Gln 
        915                 920                 925             


Gln Cys Gly Phe Phe Gln Trp Val Asp Glu Asn Thr Ala Pro Gly Thr 
    930                 935                 940                 


Ser Gly Ala Pro Ser Trp Thr Gly Asp Arg Gly Arg Thr Leu Glu Ser 
945                 950                 955                 960 


Glu Ala Arg Ser Lys Arg Pro Arg Ala Ser Ser Ser Asp Met Gly Ser 
                965                 970                 975     


Thr Ala Lys Lys Pro Arg Lys Cys Ser Leu Cys His Gln Pro Gly His 
            980                 985                 990         


Thr Arg Pro Phe Cys Pro Gln Asn  Arg 
        995                 1000     


<210>  242
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ala His Asn Lys Ile Pro Pro Arg Trp Leu Asn Cys Pro Arg Arg 
1               5                   10                  15      


Gly Gln Pro Val Ala Gly Arg Phe Leu Pro Leu Lys Thr Met Leu Gly 
            20                  25                  30          


Pro Arg Tyr Asp Ser Gln Val Ala Glu Glu Asn Arg Phe His Pro Ser 
        35                  40                  45              


Met Leu Ser Asn Tyr Leu Lys Ser Leu Lys Val Lys Met Gly Leu Leu 
    50                  55                  60                  


Val Asp Leu Thr Asn Thr Ser Arg Phe Tyr Asp Arg Asn Asp Ile Glu 
65                  70                  75                  80  


Lys Glu Gly Ile Lys Tyr Ile Lys Leu Gln Cys Lys Gly His Gly Glu 
                85                  90                  95      


Cys Pro Thr Thr Glu Asn Thr Glu Thr Phe Ile Arg Leu Cys Glu Arg 
            100                 105                 110         


Phe Asn Glu Arg Asn Pro Pro Glu Leu Ile Gly Val His Cys Thr His 
        115                 120                 125             


Gly Phe Asn Arg Thr Gly Phe Leu Ile Cys Ala Phe Leu Val Glu Lys 
    130                 135                 140                 


Met Asp Trp Ser Ile Glu Ala Ala Val Ala Thr Phe Ala Gln Ala Arg 
145                 150                 155                 160 


Pro Pro Gly Ile Tyr Lys Gly Asp Tyr Leu Lys Glu Leu Phe Arg Arg 
                165                 170                 175     


Tyr Gly Asp Ile Glu Glu Ala Pro Pro Pro Pro Leu Leu Pro Asp Trp 
            180                 185                 190         


Cys Phe Glu Asp Asp Glu Asp Glu Asp Glu Asp Glu Asp Gly Lys Lys 
        195                 200                 205             


Glu Ser Glu Pro Gly Ser Ser Ala Ser Phe Gly Lys Arg Arg Lys Glu 
    210                 215                 220                 


Arg Leu Lys Leu Gly Ala Ile Phe Leu Glu Gly Val Thr Val Lys Gly 
225                 230                 235                 240 


Val Thr Gln Val Thr Thr Gln Pro Lys Leu Gly Glu Val Gln Gln Lys 
                245                 250                 255     


Cys His Gln Phe Cys Gly Trp Glu Gly Ser Gly Phe Pro Gly Ala Gln 
            260                 265                 270         


Pro Val Ser Met Asp Lys Gln Asn Ile Lys Leu Leu Asp Leu Lys Pro 
        275                 280                 285             


Tyr Lys Val Ser Trp Lys Ala Asp Gly Thr Arg Tyr Met Met Leu Ile 
    290                 295                 300                 


Asp Gly Thr Asn Glu Val Phe Met Ile Asp Arg Asp Asn Ser Val Phe 
305                 310                 315                 320 


His Val Ser Asn Leu Glu Phe Pro Phe Arg Lys Asp Leu Arg Met His 
                325                 330                 335     


Leu Ser Asn Thr Leu Leu Asp Gly Glu Met Ile Ile Asp Arg Val Asn 
            340                 345                 350         


Gly Gln Ala Val Pro Arg Tyr Leu Ile Tyr Asp Ile Ile Lys Phe Asn 
        355                 360                 365             


Ser Gln Pro Val Gly Asp Cys Asp Phe Asn Val Arg Leu Gln Cys Ile 
    370                 375                 380                 


Glu Arg Glu Ile Ile Ser Pro Arg His Glu Lys Met Lys Thr Gly Leu 
385                 390                 395                 400 


Ile Asp Lys Thr Gln Glu Pro Phe Ser Val Arg Asn Lys Pro Phe Phe 
                405                 410                 415     


Asp Ile Cys Thr Ser Arg Lys Leu Leu Glu Gly Asn Phe Ala Lys Glu 
            420                 425                 430         


Val Ser His Glu Met Asp Gly Leu Ile Phe Gln Pro Thr Gly Lys Tyr 
        435                 440                 445             


Lys Pro Gly Arg Cys Asp Asp Ile Leu Lys Trp Lys Pro Pro Ser Leu 
    450                 455                 460                 


Asn Ser Val Asp Phe Arg Leu Lys Ile Thr Arg Met Gly Gly Glu Gly 
465                 470                 475                 480 


Leu Leu Pro Gln Asn Val Gly Leu Leu Tyr Val Gly Gly Tyr Glu Arg 
                485                 490                 495     


Pro Phe Ala Gln Ile Lys Val Thr Lys Glu Leu Lys Gln Tyr Asp Asn 
            500                 505                 510         


Lys Ile Ile Glu Cys Lys Phe Glu Asn Asn Ser Trp Val Phe Met Arg 
        515                 520                 525             


Gln Arg Thr Asp Lys Ser Phe Pro Asn Ala Tyr Asn Thr Ala Met Ala 
    530                 535                 540                 


Val Cys Asn Ser Ile Ser Asn Pro Val Thr Lys Glu Met Leu Phe Glu 
545                 550                 555                 560 


Phe Ile Asp Arg Cys Thr Ala Ala Ser Gln Gly Gln Lys Arg Lys His 
                565                 570                 575     


His Leu Asp Pro Asp Thr Glu Leu Met Pro Pro Pro Pro Pro Lys Arg 
            580                 585                 590         


Pro Arg Pro Leu Thr 
        595         


<210>  243
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Gly Ala Gly Gly Gly Gly Cys Pro Ala Gly Gly Asn Asp Phe 
1               5                   10                  15      


Gln Trp Cys Phe Ser Gln Val Lys Gly Ala Ile Asp Glu Asp Val Ala 
            20                  25                  30          


Glu Ala Asp Ile Ile Ser Thr Val Glu Phe Asn Tyr Ser Gly Asp Leu 
        35                  40                  45              


Leu Ala Thr Gly Asp Lys Gly Gly Arg Val Val Ile Phe Gln Arg Glu 
    50                  55                  60                  


Gln Glu Asn Lys Ser Arg Pro His Ser Arg Gly Glu Tyr Asn Val Tyr 
65                  70                  75                  80  


Ser Thr Phe Gln Ser His Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu 
                85                  90                  95      


Glu Ile Glu Glu Lys Ile Asn Lys Ile Arg Trp Leu Pro Gln Gln Asn 
            100                 105                 110         


Ala Ala His Phe Leu Leu Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp 
        115                 120                 125             


Lys Ile Ser Glu Arg Asp Lys Arg Ala Glu Gly Tyr Asn Leu Lys Asp 
    130                 135                 140                 


Glu Asp Gly Arg Leu Arg Asp Pro Phe Arg Ile Thr Ala Leu Arg Val 
145                 150                 155                 160 


Pro Ile Leu Lys Pro Met Asp Leu Met Val Glu Ala Ser Pro Arg Arg 
                165                 170                 175     


Ile Phe Ala Asn Ala His Thr Tyr His Ile Asn Ser Ile Ser Val Asn 
            180                 185                 190         


Ser Asp His Glu Thr Tyr Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu 
        195                 200                 205             


Trp His Leu Glu Ile Thr Asp Arg Ser Phe Asn Ile Val Asp Ile Lys 
    210                 215                 220                 


Pro Ala Asn Met Glu Glu Leu Thr Glu Val Ile Thr Ala Ala Glu Phe 
225                 230                 235                 240 


His Pro His Gln Cys Asn Val Phe Val Tyr Ser Ser Ser Lys Gly Thr 
                245                 250                 255     


Ile Arg Leu Cys Asp Met Arg Ser Ser Ala Leu Cys Asp Arg His Ser 
            260                 265                 270         


Lys Phe Phe Glu Glu Pro Glu Asp Pro Ser Ser Arg Ser Phe Phe Ser 
        275                 280                 285             


Glu Ile Ile Ser Ser Ile Ser Asp Val Lys Phe Ser His Ser Gly Arg 
    290                 295                 300                 


Tyr Met Met Thr Arg Asp Tyr Leu Ser Val Lys Val Trp Asp Leu Asn 
305                 310                 315                 320 


Met Glu Ser Arg Pro Val Glu Thr His Gln Val His Glu Tyr Leu Arg 
                325                 330                 335     


Ser Lys Leu Cys Ser Leu Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe 
            340                 345                 350         


Glu Cys Cys Trp Asn Gly Ser Asp Ser Ala Ile Met Thr Gly Ser Tyr 
        355                 360                 365             


Asn Asn Phe Phe Arg Met Phe Asp Arg Asp Thr Arg Arg Asp Val Thr 
    370                 375                 380                 


Leu Glu Ala Ser Arg Glu Ser Ser Lys Pro Arg Ala Ser Leu Lys Pro 
385                 390                 395                 400 


Arg Lys Val Cys Thr Gly Gly Lys Arg Arg Lys Asp Glu Ile Ser Val 
                405                 410                 415     


Asp Ser Leu Asp Phe Asn Lys Lys Ile Leu His Thr Ala Trp His Pro 
            420                 425                 430         


Val Asp Asn Val Ile Ala Val Ala Ala Thr Asn Asn Leu Tyr Ile Phe 
        435                 440                 445             


Gln Asp Lys Ile Asn 
    450             


<210>  244
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Ser Leu Gln Ser Ala Gln Tyr Leu Arg Gln Ala Glu Val Leu Lys 
1               5                   10                  15      


Ala Asp Met Thr Asp Ser Lys Leu Gly Pro Ala Glu Val Trp Thr Ser 
            20                  25                  30          


Arg Gln Ala Leu Gln Asp Leu Tyr Gln Lys Met Leu Val Thr Asp Leu 
        35                  40                  45              


Glu Tyr Ala Leu Asp Lys Lys Val Glu Gln Asp Leu Trp Asn His Ala 
    50                  55                  60                  


Phe Lys Asn Gln Ile Thr Thr Leu Gln Gly Gln Ala Lys Asn Arg Ala 
65                  70                  75                  80  


Asn Pro Asn Arg Ser Glu Val Gln Ala Asn Leu Ser Leu Phe Leu Glu 
                85                  90                  95      


Ala Ala Ser Gly Phe Tyr Thr Gln Leu Leu Gln Glu Leu Cys Thr Val 
            100                 105                 110         


Phe Asn Val Asp Leu Pro Cys Arg Val Lys Ser Ser Gln Leu Gly Ile 
        115                 120                 125             


Ile Ser Asn Lys Gln Thr His Thr Ser Ala Ile Val Lys Pro Gln Ser 
    130                 135                 140                 


Ser Ser Cys Ser Tyr Ile Cys Gln His Cys Leu Val His Leu Gly Asp 
145                 150                 155                 160 


Ile Ala Arg Tyr Arg Asn Gln Thr Ser Gln Ala Glu Ser Tyr Tyr Arg 
                165                 170                 175     


His Ala Ala Gln Leu Val Pro Ser Asn Gly Gln Pro Tyr Asn Gln Leu 
            180                 185                 190         


Ala Ile Leu Ala Ser Ser Lys Gly Asp His Leu Thr Thr Ile Phe Tyr 
        195                 200                 205             


Tyr Cys Arg Ser Ile Ala Val Lys Phe Pro Phe Pro Ala Ala Ser Thr 
    210                 215                 220                 


Asn Leu Gln Lys Ala Leu Ser Lys Ala Leu Glu Ser Arg Asp Glu Val 
225                 230                 235                 240 


Lys Thr Lys Trp Gly Val Ser Asp Phe Ile Lys Ala Phe Ile Lys Phe 
                245                 250                 255     


His Gly His Val Tyr Leu Ser Lys Ser Leu Glu Lys Leu Ser Pro Leu 
            260                 265                 270         


Arg Glu Lys Leu Glu Glu Gln Phe Lys Arg Leu Leu Phe Gln Lys Ala 
        275                 280                 285             


Phe Asn Ser Gln Gln Leu Val His Val Thr Val Ile Asn Leu Phe Gln 
    290                 295                 300                 


Leu His His Leu Arg Asp Phe Ser Asn Glu Thr Glu Gln His Thr Tyr 
305                 310                 315                 320 


Ser Gln Asp Glu Gln Leu Cys Trp Thr Gln Leu Leu Ala Leu Phe Met 
                325                 330                 335     


Ser Phe Leu Gly Ile Leu Cys Lys Cys Pro Leu Gln Asn Glu Ser Gln 
            340                 345                 350         


Glu Glu Ser Tyr Asn Ala Tyr Pro Leu Pro Ala Val Lys Val Ser Met 
        355                 360                 365             


Asp Trp Leu Arg Leu Arg Pro Arg Val Phe Gln Glu Ala Val Val Asp 
    370                 375                 380                 


Glu Arg Gln Tyr Ile Trp Pro Trp Leu Ile Ser Leu Leu Asn Ser Phe 
385                 390                 395                 400 


His Pro His Glu Glu Asp Leu Ser Ser Ile Ser Ala Thr Pro Leu Pro 
                405                 410                 415     


Glu Glu Phe Glu Leu Gln Gly Phe Leu Ala Leu Arg Pro Ser Phe Arg 
            420                 425                 430         


Asn Leu Asp Phe Ser Lys Gly His Gln Gly Ile Thr Gly Asp Lys Glu 
        435                 440                 445             


Gly Gln Gln Arg Arg Ile Arg Gln Gln Arg Leu Ile Ser Ile Gly Lys 
    450                 455                 460                 


Trp Ile Ala Asp Asn Gln Pro Arg Leu Ile Gln Cys Glu Asn Glu Val 
465                 470                 475                 480 


Gly Lys Leu Leu Phe Ile Thr Glu Ile Pro Glu Leu Ile Leu Glu Asp 
                485                 490                 495     


Pro Ser Glu Ala Lys Glu Asn Leu Ile Leu Gln Glu Thr Ser Val Ile 
            500                 505                 510         


Glu Ser Leu Ala Ala Asp Gly Ser Pro Gly Leu Lys Ser Val Leu Ser 
        515                 520                 525             


Thr Ser Arg Asn Leu Ser Asn Asn Cys Asp Thr Gly Glu Lys Pro Val 
    530                 535                 540                 


Val Thr Phe Lys Glu Asn Ile Lys Thr Arg Glu Val Asn Arg Asp Gln 
545                 550                 555                 560 


Gly Arg Ser Phe Pro Pro Lys Glu Val Arg Arg Asp Tyr Ser Lys Gly 
                565                 570                 575     


Ile Thr Val Thr Lys Asn Asp Gly Lys Lys Asp Asn Asn Lys Arg Lys 
            580                 585                 590         


Thr Glu Thr Lys Lys Cys Thr Leu Glu Lys Leu Gln Glu Thr Gly Lys 
        595                 600                 605             


Gln Asn Val Ala Val Gln Val Lys Ser Gln Thr Glu Leu Arg Lys Thr 
    610                 615                 620                 


Pro Val Ser Glu Ala Arg Lys Thr Pro Val Thr Gln Thr Pro Thr Gln 
625                 630                 635                 640 


Ala Ser Asn Ser Gln Phe Ile Pro Ile His His Pro Gly Ala Phe Pro 
                645                 650                 655     


Pro Leu Pro Ser Arg Pro Gly Phe Pro Pro Pro Thr Tyr Val Ile Pro 
            660                 665                 670         


Pro Pro Val Ala Phe Ser Met Gly Ser Gly Tyr Thr Phe Pro Ala Gly 
        675                 680                 685             


Val Ser Val Pro Gly Thr Phe Leu Gln Pro Thr Ala His Ser Pro Ala 
    690                 695                 700                 


Gly Asn Gln Val Gln Ala Gly Lys Gln Ser His Ile Pro Tyr Ser Gln 
705                 710                 715                 720 


Gln Arg Pro Ser Gly Pro Gly Pro Met Asn Gln Gly Pro Gln Gln Ser 
                725                 730                 735     


Gln Pro Pro Ser Gln Gln Pro Leu Thr Ser Leu Pro Ala Gln Pro Thr 
            740                 745                 750         


Ala Gln Ser Thr Ser Gln Leu Gln Val Gln Ala Leu Thr Gln Gln Gln 
        755                 760                 765             


Gln Ser Pro Thr Lys Ala Val Pro Ala Leu Gly Lys Ser Pro Pro His 
    770                 775                 780                 


His Ser Gly Phe Gln Gln Tyr Gln Gln Ala Asp Ala Ser Lys Gln Leu 
785                 790                 795                 800 


Trp Asn Pro Pro Gln Val Gln Gly Pro Leu Gly Lys Ile Met Pro Val 
                805                 810                 815     


Lys Gln Pro Tyr Tyr Leu Gln Thr Gln Asp Pro Ile Lys Leu Phe Glu 
            820                 825                 830         


Pro Ser Leu Gln Pro Pro Val Met Gln Gln Gln Pro Leu Glu Lys Lys 
        835                 840                 845             


Met Lys Pro Phe Pro Met Glu Pro Tyr Asn His Asn Pro Ser Glu Val 
    850                 855                 860                 


Lys Val Pro Glu Phe Tyr Trp Asp Ser Ser Tyr Ser Met Ala Asp Asn 
865                 870                 875                 880 


Arg Ser Val Met Ala Gln Gln Ala Asn Ile Asp Arg Arg Gly Lys Arg 
                885                 890                 895     


Ser Pro Gly Val Phe Arg Pro Glu Gln Asp Pro Val Pro Arg Met Pro 
            900                 905                 910         


Phe Glu Lys Ser Leu Leu Glu Lys Pro Ser Glu Leu Met Ser His Ser 
        915                 920                 925             


Ser Ser Phe Leu Ser Leu Thr Gly Phe Ser Leu Asn Gln Glu Arg Tyr 
    930                 935                 940                 


Pro Asn Asn Ser Met Phe Asn Glu Val Tyr Gly Lys Asn Leu Thr Ser 
945                 950                 955                 960 


Ser Ser Lys Ala Glu Leu Ser Pro Ser Met Ala Pro Gln Glu Thr Ser 
                965                 970                 975     


Leu Tyr Ser Leu Phe Glu Gly Thr Pro Trp Ser Pro Ser Leu Pro Ala 
            980                 985                 990         


Ser Ser Asp His Ser Thr Pro Ala  Ser Gln Ser Pro His  Ser Ser Asn 
        995                 1000                 1005             


Pro Ser  Ser Leu Pro Ser Ser  Pro Pro Thr His Asn  His Asn Ser 
    1010                 1015                 1020             


Val Pro  Phe Ser Asn Phe Gly  Pro Ile Gly Thr Pro  Asp Asn Arg 
    1025                 1030                 1035             


Asp Arg  Arg Thr Ala Asp Arg  Trp Lys Thr Asp Lys  Pro Ala Met 
    1040                 1045                 1050             


Gly Gly  Phe Gly Ile Asp Tyr  Leu Ser Ala Thr Ser  Ser Ser Glu 
    1055                 1060                 1065             


Ser Ser  Trp His Gln Ala Ser  Thr Pro Ser Gly Thr  Trp Thr Gly 
    1070                 1075                 1080             


His Gly  Pro Ser Met Glu Asp  Ser Ser Ala Val Leu  Met Glu Ser 
    1085                 1090                 1095             


Leu Lys  Ser Ile Trp Ser Ser  Ser Met Met His Pro  Gly Pro Ser 
    1100                 1105                 1110             


Ala Leu  Glu Gln Leu Leu Met  Gln Gln Lys Gln Lys  Gln Gln Arg 
    1115                 1120                 1125             


Gly Gln  Gly Thr Met Asn Pro  Pro His 
    1130                 1135         


<210>  245
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Asn Asn Ser Gly Ala Asp Glu Ile Gly Lys Leu Phe Val Gly Gly 
1               5                   10                  15      


Leu Asp Trp Ser Thr Thr Gln Glu Thr Leu Arg Ser Tyr Phe Ser Gln 
            20                  25                  30          


Tyr Gly Glu Val Val Asp Cys Val Ile Met Lys Asp Lys Thr Thr Asn 
        35                  40                  45              


Gln Ser Arg Gly Phe Gly Phe Val Lys Phe Lys Asp Pro Asn Cys Val 
    50                  55                  60                  


Gly Thr Val Leu Ala Ser Arg Pro His Thr Leu Asp Gly Arg Asn Ile 
65                  70                  75                  80  


Asp Pro Lys Pro Cys Thr Pro Arg Gly Met Gln Pro Glu Arg Thr Arg 
                85                  90                  95      


Pro Lys Glu Gly Trp Gln Lys Gly Pro Arg Ser Asp Asn Ser Lys Ser 
            100                 105                 110         


Asn Lys Ile Phe Val Gly Gly Ile Pro His Asn Cys Gly Glu Thr Glu 
        115                 120                 125             


Leu Arg Glu Tyr Phe Lys Lys Phe Gly Val Val Thr Glu Val Val Met 
    130                 135                 140                 


Ile Tyr Asp Ala Glu Lys Gln Arg Pro Arg Gly Phe Gly Phe Ile Thr 
145                 150                 155                 160 


Phe Glu Asp Glu Gln Ser Val Asp Gln Ala Val Asn Met His Phe His 
                165                 170                 175     


Asp Ile Met Gly Lys Lys Val Glu Val Lys Arg Ala Glu Pro Arg Asp 
            180                 185                 190         


Ser Lys Ser Gln Ala Pro Gly Gln Pro Gly Ala Ser Gln Trp Gly Ser 
        195                 200                 205             


Arg Val Val Pro Asn Ala Ala Asn Gly Trp Ala Gly Gln Pro Pro Pro 
    210                 215                 220                 


Thr Trp Gln Gln Gly Tyr Gly Pro Gln Gly Met Trp Val Pro Ala Gly 
225                 230                 235                 240 


Gln Ala Ile Gly Gly Tyr Gly Pro Pro Pro Ala Gly Arg Gly Ala Pro 
                245                 250                 255     


Pro Pro Pro Pro Pro Phe Thr Ser Tyr Ile Val Ser Thr Pro Pro Gly 
            260                 265                 270         


Gly Phe Pro Pro Pro Gln Gly Phe Pro Gln Gly Tyr Gly Ala Pro Pro 
        275                 280                 285             


Gln Phe Ser Phe Gly Tyr Gly Pro Pro Pro Pro Pro Pro Asp Gln Phe 
    290                 295                 300                 


Ala Pro Pro Gly Val Pro Pro Pro Pro Ala Thr Pro Gly Ala Ala Pro 
305                 310                 315                 320 


Leu Ala Phe Pro Pro Pro Pro Ser Gln Ala Ala Pro Asp Met Ser Lys 
                325                 330                 335     


Pro Pro Thr Ala Gln Pro Asp Phe Pro Tyr Gly Gln Tyr Ala Gly Tyr 
            340                 345                 350         


Gly Gln Asp Leu Ser Gly Phe Gly Gln Gly Phe Ser Asp Pro Ser Gln 
        355                 360                 365             


Gln Pro Pro Ser Tyr Gly Gly Pro Ser Val Pro Gly Ser Gly Gly Pro 
    370                 375                 380                 


Pro Ala Gly Gly Ser Gly Phe Gly Arg Gly Gln Asn His Asn Val Gln 
385                 390                 395                 400 


Gly Phe His Pro Tyr Arg Arg 
                405         


<210>  246
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Lys Leu Thr Asp Ser Val Leu Arg Ser Phe Arg Val Ala Lys Val 
1               5                   10                  15      


Phe Arg Glu Asn Ser Asp Lys Ile Asn Cys Phe Asp Phe Ser Pro Asn 
            20                  25                  30          


Gly Glu Thr Val Ile Ser Ser Ser Asp Asp Asp Ser Ile Val Leu Tyr 
        35                  40                  45              


Asp Cys Gln Glu Gly Lys Pro Lys Arg Thr Leu Tyr Ser Lys Lys Tyr 
    50                  55                  60                  


Gly Val Asp Leu Ile Arg Tyr Thr His Ala Ala Asn Thr Val Val Tyr 
65                  70                  75                  80  


Ser Ser Asn Lys Ile Asp Asp Thr Ile Arg Tyr Leu Ser Leu His Asp 
                85                  90                  95      


Asn Lys Tyr Ile Arg Tyr Phe Pro Gly His Ser Lys Arg Val Val Ala 
            100                 105                 110         


Leu Ser Met Ser Pro Val Asp Asp Thr Phe Ile Ser Gly Ser Leu Asp 
        115                 120                 125             


Lys Thr Ile Arg Leu Trp Asp Leu Arg Ser Pro Asn Cys Gln Gly Leu 
    130                 135                 140                 


Met His Leu Gln Gly Lys Pro Val Cys Ser Phe Asp Pro Glu Gly Leu 
145                 150                 155                 160 


Ile Phe Ala Ala Gly Val Asn Ser Glu Met Val Lys Leu Tyr Asp Leu 
                165                 170                 175     


Arg Ser Phe Asp Lys Gly Pro Phe Ala Thr Phe Lys Met Gln Tyr Asp 
            180                 185                 190         


Arg Thr Cys Glu Trp Thr Gly Leu Lys Phe Ser Asn Asp Gly Lys Leu 
        195                 200                 205             


Ile Leu Ile Ser Thr Asn Gly Ser Phe Ile Arg Leu Ile Asp Ala Phe 
    210                 215                 220                 


Lys Gly Val Val Met His Thr Phe Gly Gly Tyr Ala Asn Ser Lys Ala 
225                 230                 235                 240 


Val Thr Leu Glu Ala Ser Phe Thr Pro Asp Ser Gln Phe Ile Met Ile 
                245                 250                 255     


Gly Ser Glu Asp Gly Lys Ile His Val Trp Asn Gly Glu Ser Gly Ile 
            260                 265                 270         


Lys Val Ala Val Leu Asp Gly Lys His Thr Gly Pro Ile Thr Cys Leu 
        275                 280                 285             


Gln Phe Asn Pro Lys Phe Met Thr Phe Ala Ser Ala Cys Ser Asn Met 
    290                 295                 300                 


Ala Phe Trp Leu Pro Thr Ile Asp Asp 
305                 310             


<210>  247
<211>  684
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Ser Ala Ile Pro Ala Glu Glu Ser Asp Gln Leu Leu Ile Arg Pro 
1               5                   10                  15      


Leu Gly Ala Gly Gln Glu Val Gly Arg Ser Cys Ile Ile Leu Glu Phe 
            20                  25                  30          


Lys Gly Arg Lys Ile Met Leu Asp Cys Gly Ile His Pro Gly Leu Glu 
        35                  40                  45              


Gly Met Asp Ala Leu Pro Tyr Ile Asp Leu Ile Asp Pro Ala Glu Ile 
    50                  55                  60                  


Asp Leu Leu Leu Ile Ser His Phe His Leu Asp His Cys Gly Ala Leu 
65                  70                  75                  80  


Pro Trp Phe Leu Gln Lys Thr Ser Phe Lys Gly Arg Thr Phe Met Thr 
                85                  90                  95      


His Ala Thr Lys Ala Ile Tyr Arg Trp Leu Leu Ser Asp Tyr Val Lys 
            100                 105                 110         


Val Ser Asn Ile Ser Ala Asp Asp Met Leu Tyr Thr Glu Thr Asp Leu 
        115                 120                 125             


Glu Glu Ser Met Asp Lys Ile Glu Thr Ile Asn Phe His Glu Val Lys 
    130                 135                 140                 


Glu Val Ala Gly Ile Lys Phe Trp Cys Tyr His Ala Gly His Val Leu 
145                 150                 155                 160 


Gly Ala Ala Met Phe Met Ile Glu Ile Ala Gly Val Lys Leu Leu Tyr 
                165                 170                 175     


Thr Gly Asp Phe Ser Arg Gln Glu Asp Arg His Leu Met Ala Ala Glu 
            180                 185                 190         


Ile Pro Asn Ile Lys Pro Asp Ile Leu Ile Ile Glu Ser Thr Tyr Gly 
        195                 200                 205             


Thr His Ile His Glu Lys Arg Glu Glu Arg Glu Ala Arg Phe Cys Asn 
    210                 215                 220                 


Thr Val His Asp Ile Val Asn Arg Gly Gly Arg Gly Leu Ile Pro Val 
225                 230                 235                 240 


Phe Ala Leu Gly Arg Ala Gln Glu Leu Leu Leu Ile Leu Asp Glu Tyr 
                245                 250                 255     


Trp Gln Asn His Pro Glu Leu His Asp Ile Pro Ile Tyr Tyr Ala Ser 
            260                 265                 270         


Ser Leu Ala Lys Lys Cys Met Ala Val Tyr Gln Thr Tyr Val Asn Ala 
        275                 280                 285             


Met Asn Asp Lys Ile Arg Lys Gln Ile Asn Ile Asn Asn Pro Phe Val 
    290                 295                 300                 


Phe Lys His Ile Ser Asn Leu Lys Ser Met Asp His Phe Asp Asp Ile 
305                 310                 315                 320 


Gly Pro Ser Val Val Met Ala Ser Pro Gly Met Met Gln Ser Gly Leu 
                325                 330                 335     


Ser Arg Glu Leu Phe Glu Ser Trp Cys Thr Asp Lys Arg Asn Gly Val 
            340                 345                 350         


Ile Ile Ala Gly Tyr Cys Val Glu Gly Thr Leu Ala Lys His Ile Met 
        355                 360                 365             


Ser Glu Pro Glu Glu Ile Thr Thr Met Ser Gly Gln Lys Leu Pro Leu 
    370                 375                 380                 


Lys Met Ser Val Asp Tyr Ile Ser Phe Ser Ala His Thr Asp Tyr Gln 
385                 390                 395                 400 


Gln Thr Ser Glu Phe Ile Arg Ala Leu Lys Pro Pro His Val Ile Leu 
                405                 410                 415     


Val His Gly Glu Gln Asn Glu Met Ala Arg Leu Lys Ala Ala Leu Ile 
            420                 425                 430         


Arg Glu Tyr Glu Asp Asn Asp Glu Val His Ile Glu Val His Asn Pro 
        435                 440                 445             


Arg Asn Thr Glu Ala Val Thr Leu Asn Phe Arg Gly Glu Lys Leu Ala 
    450                 455                 460                 


Lys Val Met Gly Phe Leu Ala Asp Lys Lys Pro Glu Gln Gly Gln Arg 
465                 470                 475                 480 


Val Ser Gly Ile Leu Val Lys Arg Asn Phe Asn Tyr His Ile Leu Ser 
                485                 490                 495     


Pro Cys Asp Leu Ser Asn Tyr Thr Asp Leu Ala Met Ser Thr Val Lys 
            500                 505                 510         


Gln Thr Gln Ala Ile Pro Tyr Thr Gly Pro Phe Asn Leu Leu Cys Tyr 
        515                 520                 525             


Gln Leu Gln Lys Leu Thr Gly Asp Val Glu Glu Leu Glu Ile Gln Glu 
    530                 535                 540                 


Lys Pro Ala Leu Lys Val Phe Lys Asn Ile Thr Val Ile Gln Glu Pro 
545                 550                 555                 560 


Gly Met Val Val Leu Glu Trp Leu Ala Asn Pro Ser Asn Asp Met Tyr 
                565                 570                 575     


Ala Asp Thr Val Thr Thr Val Ile Leu Glu Val Gln Ser Asn Pro Lys 
            580                 585                 590         


Ile Arg Lys Gly Ala Val Gln Lys Val Ser Lys Lys Leu Glu Met His 
        595                 600                 605             


Val Tyr Ser Lys Arg Leu Glu Ile Met Leu Gln Asp Ile Phe Gly Glu 
    610                 615                 620                 


Asp Cys Val Ser Val Lys Asp Asp Ser Ile Leu Ser Val Thr Val Asp 
625                 630                 635                 640 


Gly Lys Thr Ala Asn Leu Asn Leu Glu Thr Arg Thr Val Glu Cys Glu 
                645                 650                 655     


Glu Gly Ser Glu Asp Asp Glu Ser Leu Arg Glu Met Val Glu Leu Ala 
            660                 665                 670         


Ala Gln Arg Leu Tyr Glu Ala Leu Thr Pro Val His 
        675                 680                 


<210>  248
<211>  1274
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ala Ser Gly Ser Gly Asp Ser Val Thr Arg Arg Ser Val Ala Ser 
1               5                   10                  15      


Gln Phe Phe Thr Gln Glu Glu Gly Pro Gly Ile Asp Gly Met Thr Thr 
            20                  25                  30          


Ser Glu Arg Val Val Asp Leu Leu Asn Gln Ala Ala Leu Ile Thr Asn 
        35                  40                  45              


Asp Ser Lys Ile Thr Val Leu Lys Gln Val Gln Glu Leu Ile Ile Asn 
    50                  55                  60                  


Lys Asp Pro Thr Leu Leu Asp Asn Phe Leu Asp Glu Ile Ile Ala Phe 
65                  70                  75                  80  


Gln Ala Asp Lys Ser Ile Glu Val Arg Lys Phe Val Ile Gly Phe Ile 
                85                  90                  95      


Glu Glu Ala Cys Lys Arg Asp Ile Glu Leu Leu Leu Lys Leu Ile Ala 
            100                 105                 110         


Asn Leu Asn Met Leu Leu Arg Asp Glu Asn Val Asn Val Val Lys Lys 
        115                 120                 125             


Ala Ile Leu Thr Met Thr Gln Leu Tyr Lys Val Ala Leu Gln Trp Met 
    130                 135                 140                 


Val Lys Ser Arg Val Ile Ser Glu Leu Gln Glu Ala Cys Trp Asp Met 
145                 150                 155                 160 


Val Ser Ala Met Ala Gly Asp Ile Ile Leu Leu Leu Asp Ser Asp Asn 
                165                 170                 175     


Asp Gly Ile Arg Thr His Ala Ile Lys Phe Val Glu Gly Leu Ile Val 
            180                 185                 190         


Thr Leu Ser Pro Arg Met Ala Asp Ser Glu Ile Pro Arg Arg Gln Glu 
        195                 200                 205             


His Asp Ile Ser Leu Asp Arg Ile Pro Arg Asp His Pro Tyr Ile Gln 
    210                 215                 220                 


Tyr Asn Val Leu Trp Glu Glu Gly Lys Ala Ala Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Lys Phe Met Val His Pro Ala Ile Ser Ser Ile Asn Leu Thr Thr Ala 
                245                 250                 255     


Leu Gly Ser Leu Ala Asn Ile Ala Arg Gln Arg Pro Met Phe Met Ser 
            260                 265                 270         


Glu Val Ile Gln Ala Tyr Glu Thr Leu His Ala Asn Leu Pro Pro Thr 
        275                 280                 285             


Leu Ala Lys Ser Gln Val Ser Ser Val Arg Lys Asn Leu Lys Leu His 
    290                 295                 300                 


Leu Leu Ser Val Leu Lys His Pro Ala Ser Leu Glu Phe Gln Ala Gln 
305                 310                 315                 320 


Ile Thr Thr Leu Leu Val Asp Leu Gly Thr Pro Gln Ala Glu Ile Ala 
                325                 330                 335     


Arg Asn Met Pro Ser Ser Lys Asp Thr Arg Lys Arg Pro Arg Asp Asp 
            340                 345                 350         


Ser Asp Ser Thr Leu Lys Lys Met Lys Leu Glu Pro Asn Leu Gly Glu 
        355                 360                 365             


Asp Asp Glu Asp Lys Asp Leu Glu Pro Gly Pro Ser Gly Thr Ser Lys 
    370                 375                 380                 


Ala Ser Ala Gln Ile Ser Gly Gln Ser Asp Thr Asp Ile Thr Ala Glu 
385                 390                 395                 400 


Phe Leu Gln Pro Leu Leu Thr Pro Asp Asn Val Ala Asn Leu Val Leu 
                405                 410                 415     


Ile Ser Met Val Tyr Leu Pro Glu Ala Met Pro Ala Ser Phe Gln Ala 
            420                 425                 430         


Ile Tyr Thr Pro Val Glu Ser Ala Gly Thr Glu Ala Gln Ile Lys His 
        435                 440                 445             


Leu Ala Arg Leu Met Ala Thr Gln Met Thr Ala Ala Gly Leu Gly Pro 
    450                 455                 460                 


Gly Val Glu Gln Thr Lys Gln Cys Lys Glu Glu Pro Lys Glu Glu Lys 
465                 470                 475                 480 


Val Val Lys Thr Glu Ser Val Leu Ile Lys Arg Arg Leu Ser Ala Gln 
                485                 490                 495     


Gly Gln Ala Ile Ser Val Val Gly Ser Leu Ser Ser Met Ser Pro Leu 
            500                 505                 510         


Glu Glu Glu Ala Pro Gln Ala Lys Arg Arg Pro Glu Pro Ile Ile Pro 
        515                 520                 525             


Val Thr Gln Pro Arg Leu Ala Gly Ala Gly Gly Arg Lys Lys Ile Phe 
    530                 535                 540                 


Arg Leu Ser Asp Val Leu Lys Pro Leu Thr Asp Ala Gln Val Glu Ala 
545                 550                 555                 560 


Met Lys Leu Gly Ala Val Lys Arg Ile Leu Arg Ala Glu Lys Ala Val 
                565                 570                 575     


Ala Cys Ser Gly Ala Ala Gln Val Arg Ile Lys Ile Leu Ala Ser Leu 
            580                 585                 590         


Val Thr Gln Phe Asn Ser Gly Leu Lys Ala Glu Val Leu Ser Phe Ile 
        595                 600                 605             


Leu Glu Asp Val Arg Ala Arg Leu Asp Leu Ala Phe Ala Trp Leu Tyr 
    610                 615                 620                 


Gln Glu Tyr Asn Ala Tyr Leu Ala Ala Gly Ala Ser Gly Ser Leu Asp 
625                 630                 635                 640 


Lys Tyr Glu Asp Cys Leu Ile Arg Leu Leu Ser Gly Leu Gln Glu Lys 
                645                 650                 655     


Pro Asp Gln Lys Asp Gly Ile Phe Thr Lys Val Val Leu Glu Ala Pro 
            660                 665                 670         


Leu Ile Thr Glu Ser Ala Leu Glu Val Val Arg Lys Tyr Cys Glu Asp 
        675                 680                 685             


Glu Ser Arg Thr Tyr Leu Gly Met Ser Thr Leu Arg Asp Leu Ile Phe 
    690                 695                 700                 


Lys Arg Pro Ser Arg Gln Phe Gln Tyr Leu His Val Leu Leu Asp Leu 
705                 710                 715                 720 


Ser Ser His Glu Lys Asp Lys Val Arg Ser Gln Ala Leu Leu Phe Ile 
                725                 730                 735     


Lys Arg Met Tyr Glu Lys Glu Gln Leu Arg Glu Tyr Val Glu Lys Phe 
            740                 745                 750         


Ala Leu Asn Tyr Leu Gln Leu Leu Val His Pro Asn Pro Pro Ser Val 
        755                 760                 765             


Leu Phe Gly Ala Asp Lys Asp Thr Glu Val Ala Ala Pro Trp Thr Glu 
    770                 775                 780                 


Glu Thr Val Lys Gln Cys Leu Tyr Leu Tyr Leu Ala Leu Leu Pro Gln 
785                 790                 795                 800 


Asn His Lys Leu Ile His Glu Leu Ala Ala Val Tyr Thr Glu Ala Ile 
                805                 810                 815     


Ala Asp Ile Lys Arg Thr Val Leu Arg Val Ile Glu Gln Pro Ile Arg 
            820                 825                 830         


Gly Met Gly Met Asn Ser Pro Glu Leu Leu Leu Leu Val Glu Asn Cys 
        835                 840                 845             


Pro Lys Gly Ala Glu Thr Leu Val Thr Arg Cys Leu His Ser Leu Thr 
    850                 855                 860                 


Asp Lys Val Pro Pro Ser Pro Glu Leu Val Lys Arg Val Arg Asp Leu 
865                 870                 875                 880 


Tyr His Lys Arg Leu Pro Asp Val Arg Phe Leu Ile Pro Val Leu Asn 
                885                 890                 895     


Gly Leu Glu Lys Lys Glu Val Ile Gln Ala Leu Pro Lys Leu Ile Lys 
            900                 905                 910         


Leu Asn Pro Ile Val Val Lys Glu Val Phe Asn Arg Leu Leu Gly Thr 
        915                 920                 925             


Gln His Gly Glu Gly Asn Ser Ala Leu Ser Pro Leu Asn Pro Gly Glu 
    930                 935                 940                 


Leu Leu Ile Ala Leu His Asn Ile Asp Ser Val Lys Cys Asp Met Lys 
945                 950                 955                 960 


Ser Ile Ile Lys Ala Thr Asn Leu Cys Phe Ala Glu Arg Asn Val Tyr 
                965                 970                 975     


Thr Ser Glu Val Leu Ala Val Val Met Gln Gln Leu Met Glu Gln Ser 
            980                 985                 990         


Pro Leu Pro Met Leu Leu Met Arg  Thr Val Ile Gln Ser  Leu Thr Met 
        995                 1000                 1005             


Tyr Pro  Arg Leu Gly Gly Phe  Val Met Asn Ile Leu  Ser Arg Leu 
    1010                 1015                 1020             


Ile Met  Lys Gln Val Trp Lys  Tyr Pro Lys Val Trp  Glu Gly Phe 
    1025                 1030                 1035             


Ile Lys  Cys Cys Gln Arg Thr  Lys Pro Gln Ser Phe  Gln Val Ile 
    1040                 1045                 1050             


Leu Gln  Leu Pro Pro Gln Gln  Leu Gly Ala Val Phe  Asp Lys Cys 
    1055                 1060                 1065             


Pro Glu  Leu Arg Glu Pro Leu  Leu Ala His Val Arg  Ser Phe Thr 
    1070                 1075                 1080             


Pro His  Gln Gln Ala His Ile  Pro Asn Ser Ile Met  Thr Ile Leu 
    1085                 1090                 1095             


Glu Ala  Ser Gly Lys Gln Glu  Pro Glu Ala Lys Glu  Ala Pro Ala 
    1100                 1105                 1110             


Gly Pro  Leu Glu Glu Asp Asp  Leu Glu Pro Leu Thr  Leu Ala Pro 
    1115                 1120                 1125             


Ala Pro  Ala Pro Arg Pro Pro  Gln Asp Leu Ile Gly  Leu Arg Leu 
    1130                 1135                 1140             


Ala Gln  Glu Lys Ala Leu Lys  Arg Gln Leu Glu Glu  Glu Gln Lys 
    1145                 1150                 1155             


Leu Lys  Pro Gly Gly Val Gly  Ala Pro Ser Ser Ser  Ser Pro Ser 
    1160                 1165                 1170             


Pro Ser  Pro Ser Ala Arg Pro  Gly Pro Pro Pro Ser  Glu Glu Ala 
    1175                 1180                 1185             


Met Asp  Phe Arg Glu Glu Gly  Pro Glu Cys Glu Thr  Pro Gly Ile 
    1190                 1195                 1200             


Phe Ile  Ser Met Asp Asp Asp  Ser Gly Leu Thr Glu  Ala Ala Leu 
    1205                 1210                 1215             


Leu Asp  Ser Ser Leu Glu Gly  Pro Leu Pro Lys Glu  Thr Ala Ala 
    1220                 1225                 1230             


Gly Gly  Leu Thr Leu Lys Glu  Glu Arg Ser Pro Gln  Thr Leu Ala 
    1235                 1240                 1245             


Pro Val  Gly Glu Asp Ala Met  Lys Thr Pro Ser Pro  Ala Ala Glu 
    1250                 1255                 1260             


Asp Ala  Arg Glu Pro Glu Ala  Lys Gly Asn Ser 
    1265                 1270                 


<210>  249
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Gly Val Pro Ala Phe Phe Arg Trp Leu Ser Arg Lys Tyr Pro Ser 
1               5                   10                  15      


Ile Ile Val Asn Cys Val Glu Glu Lys Pro Lys Glu Cys Asn Gly Val 
            20                  25                  30          


Lys Ile Pro Val Asp Ala Ser Lys Pro Asn Pro Asn Asp Val Glu Phe 
        35                  40                  45              


Asp Asn Leu Tyr Leu Asp Met Asn Gly Ile Ile His Pro Cys Thr His 
    50                  55                  60                  


Pro Glu Asp Lys Pro Ala Pro Lys Asn Glu Asp Glu Met Met Val Ala 
65                  70                  75                  80  


Ile Phe Glu Tyr Ile Asp Arg Leu Phe Ser Ile Val Arg Pro Arg Arg 
                85                  90                  95      


Leu Leu Tyr Met Ala Ile Asp Gly Val Ala Pro Arg Ala Lys Met Asn 
            100                 105                 110         


Gln Gln Arg Ser Arg Arg Phe Arg Ala Ser Lys Glu Gly Met Glu Ala 
        115                 120                 125             


Ala Val Glu Lys Gln Arg Val Arg Glu Glu Ile Leu Ala Lys Gly Gly 
    130                 135                 140                 


Phe Leu Pro Pro Glu Glu Ile Lys Glu Arg Phe Asp Ser Asn Cys Ile 
145                 150                 155                 160 


Thr Pro Gly Thr Glu Phe Met Asp Asn Leu Ala Lys Cys Leu Arg Tyr 
                165                 170                 175     


Tyr Ile Ala Asp Arg Leu Asn Asn Asp Pro Gly Trp Lys Asn Leu Thr 
            180                 185                 190         


Val Ile Leu Ser Asp Ala Ser Ala Pro Gly Glu Gly Glu His Lys Ile 
        195                 200                 205             


Met Asp Tyr Ile Arg Arg Gln Arg Ala Gln Pro Asn His Asp Pro Asn 
    210                 215                 220                 


Thr His His Cys Leu Cys Gly Ala Asp Ala Asp Leu Ile Met Leu Gly 
225                 230                 235                 240 


Leu Ala Thr His Glu Pro Asn Phe Thr Ile Ile Arg Glu Glu Phe Lys 
                245                 250                 255     


Pro Asn Lys Pro Lys Pro Cys Gly Leu Cys Asn Gln Phe Gly His Glu 
            260                 265                 270         


Val Lys Asp Cys Glu Gly Leu Pro Arg Glu Lys Lys Gly Lys His Asp 
        275                 280                 285             


Glu Leu Ala Asp Ser Leu Pro Cys Ala Glu Gly Glu Phe Ile Phe Leu 
    290                 295                 300                 


Arg Leu Asn Val Leu Arg Glu Tyr Leu Glu Arg Glu Leu Thr Met Ala 
305                 310                 315                 320 


Ser Leu Pro Phe Thr Phe Asp Val Glu Arg Ser Ile Asp Asp Trp Val 
                325                 330                 335     


Phe Met Cys Phe Phe Val Gly Asn Asp Phe Leu Pro His Leu Pro Ser 
            340                 345                 350         


Leu Glu Ile Arg Glu Asn Ala Ile Asp Arg Leu Val Asn Ile Tyr Lys 
        355                 360                 365             


Asn Val Val His Lys Thr Gly Gly Tyr Leu Thr Glu Ser Gly Tyr Val 
    370                 375                 380                 


Asn Leu Gln Arg Val Gln Met Ile Met Leu Ala Val Gly Glu Val Glu 
385                 390                 395                 400 


Asp Ser Ile Phe Lys Lys Arg Lys Asp Asp Glu Asp Ser Phe Arg Arg 
                405                 410                 415     


Arg Gln Lys Glu Lys Arg Lys Arg Met Lys Arg Asp Gln Pro Ala Phe 
            420                 425                 430         


Thr Pro Ser Gly Ile Leu Thr Pro His Ala Leu Gly Ser Arg Asn Ser 
        435                 440                 445             


Pro Gly Ser Gln Val Ala Ser Asn Pro Arg Gln Ala Ala Tyr Glu Met 
    450                 455                 460                 


Arg Met Gln Asn Asn Ser Ser Pro Ser Ile Ser Pro Asn Thr Ser Phe 
465                 470                 475                 480 


Thr Ser Asp Gly Ser Pro Ser Pro Leu Gly Gly Ile Lys Arg Lys Ala 
                485                 490                 495     


Glu Asp Ser Asp Ser Glu Pro Glu Pro Glu Asp Asn Val Arg Leu Trp 
            500                 505                 510         


Glu Ala Gly Trp Lys Gln Arg Tyr Tyr Lys Asn Lys Phe Asp Val Asp 
        515                 520                 525             


Ala Ala Asp Glu Lys Phe Arg Arg Lys Val Val Gln Ser Tyr Val Glu 
    530                 535                 540                 


Gly Leu Cys Trp Val Leu Arg Tyr Tyr Tyr Gln Gly Cys Ala Ser Trp 
545                 550                 555                 560 


Lys Trp Tyr Tyr Pro Phe His Tyr Ala Pro Phe Ala Ser Asp Phe Glu 
                565                 570                 575     


Gly Ile Ala Asp Met Pro Ser Asp Phe Glu Lys Gly Thr Lys Pro Phe 
            580                 585                 590         


Lys Pro Leu Glu Gln Leu Met Gly Val Phe Pro Ala Ala Ser Gly Asn 
        595                 600                 605             


Phe Leu Pro Pro Ser Trp Arg Lys Leu Met Ser Asp Pro Asp Ser Ser 
    610                 615                 620                 


Ile Ile Asp Phe Tyr Pro Glu Asp Phe Ala Ile Asp Leu Asn Gly Lys 
625                 630                 635                 640 


Lys Tyr Ala Trp Gln Gly Val Ala Leu Leu Pro Phe Val Asp Glu Arg 
                645                 650                 655     


Arg Leu Arg Ala Ala Leu Glu Glu Val Tyr Pro Asp Leu Thr Pro Glu 
            660                 665                 670         


Glu Thr Arg Arg Asn Ser Leu Gly Gly Asp Val Leu Phe Val Gly Lys 
        675                 680                 685             


His His Pro Leu His Asp Phe Ile Leu Glu Leu Tyr Gln Thr Gly Ser 
    690                 695                 700                 


Thr Glu Pro Val Glu Val Pro Pro Glu Leu Cys His Gly Ile Gln Gly 
705                 710                 715                 720 


Lys Phe Ser Leu Asp Glu Glu Ala Ile Leu Pro Asp Gln Ile Val Cys 
                725                 730                 735     


Ser Pro Val Pro Met Leu Arg Asp Leu Thr Gln Asn Thr Val Val Ser 
            740                 745                 750         


Ile Asn Phe Lys Asp Pro Gln Phe Ala Glu Asp Tyr Ile Phe Lys Ala 
        755                 760                 765             


Val Met Leu Pro Gly Ala Arg Lys Pro Ala Ala Val Leu Lys Pro Ser 
    770                 775                 780                 


Asp Trp Glu Lys Ser Ser Asn Gly Arg Gln Trp Lys Pro Gln Leu Gly 
785                 790                 795                 800 


Phe Asn Arg Asp Arg Arg Pro Val His Leu Asp Gln Ala Ala Phe Arg 
                805                 810                 815     


Thr Leu Gly His Val Met Pro Arg Gly Ser Gly Thr Gly Ile Tyr Ser 
            820                 825                 830         


Asn Ala Ala Pro Pro Pro Val Thr Tyr Gln Gly Asn Leu Tyr Arg Pro 
        835                 840                 845             


Leu Leu Arg Gly Gln Ala Gln Ile Pro Lys Leu Met Ser Asn Met Arg 
    850                 855                 860                 


Pro Gln Asp Ser Trp Arg Gly Pro Pro Pro Leu Phe Gln Gln Gln Arg 
865                 870                 875                 880 


Phe Asp Arg Gly Val Gly Ala Glu Pro Leu Leu Pro Trp Asn Arg Met 
                885                 890                 895     


Leu Gln Thr Gln Asn Ala Ala Phe Gln Pro Asn Gln Tyr Gln Met Leu 
            900                 905                 910         


Ala Gly Pro Gly Gly Tyr Pro Pro Arg Arg Asp Asp Arg Gly Gly Arg 
        915                 920                 925             


Gln Gly Tyr Pro Arg Glu Gly Arg Lys Tyr Pro Leu Pro Pro Pro Ser 
    930                 935                 940                 


Gly Arg Tyr Asn Trp Asn 
945                 950 


<210>  250
<211>  744
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Ala Ala Asp Lys Pro Ala Asp Gln Gly Ala Glu Lys His Glu Gly 
1               5                   10                  15      


Thr Gly Gln Ser Ser Gly Ile Thr Asp Gln Glu Lys Glu Leu Ser Thr 
            20                  25                  30          


Asn Ala Phe Gln Ala Phe Thr Ser Gly Asn Tyr Asp Ala Cys Leu Gln 
        35                  40                  45              


His Leu Ala Cys Leu Gln Asp Ile Asn Lys Asp Asp Tyr Lys Ile Ile 
    50                  55                  60                  


Leu Asn Thr Ala Val Ala Glu Phe Phe Lys Ser Asn Gln Thr Thr Thr 
65                  70                  75                  80  


Asp Asn Leu Arg Gln Thr Leu Asn Gln Leu Lys Asn Gln Val His Ser 
                85                  90                  95      


Ala Val Glu Glu Met Asp Gly Leu Asp Asp Val Glu Asn Ser Met Leu 
            100                 105                 110         


Tyr Tyr Asn Gln Ala Val Ile Leu Tyr His Leu Arg Gln Tyr Thr Glu 
        115                 120                 125             


Ala Ile Ser Val Gly Glu Lys Leu Tyr Gln Phe Ile Glu Pro Phe Glu 
    130                 135                 140                 


Glu Lys Phe Ala Gln Ala Val Cys Phe Leu Leu Val Asp Leu Tyr Ile 
145                 150                 155                 160 


Leu Thr Tyr Gln Ala Glu Lys Ala Leu His Leu Leu Ala Val Leu Glu 
                165                 170                 175     


Lys Met Ile Ser Gln Gly Asn Asn Asn Lys Asn Gly Lys Asn Glu Thr 
            180                 185                 190         


Gly Asn Asn Asn Asn Lys Asp Gly Ser Asn His Lys Ala Glu Ser Gly 
        195                 200                 205             


Ala Leu Ile Glu Ala Ala Lys Ser Lys Ile His Gln Tyr Lys Val Arg 
    210                 215                 220                 


Ala Tyr Ile Gln Met Lys Ser Leu Lys Ala Cys Lys Arg Glu Ile Lys 
225                 230                 235                 240 


Ser Val Met Asn Thr Ala Gly Asn Ser Ala Pro Ser Leu Phe Leu Lys 
                245                 250                 255     


Ser Asn Phe Glu Tyr Leu Arg Gly Asn Tyr Arg Lys Ala Val Lys Leu 
            260                 265                 270         


Leu Asn Ser Ser Asn Ile Ala Glu His Pro Gly Phe Met Lys Thr Gly 
        275                 280                 285             


Glu Cys Leu Arg Cys Met Phe Trp Asn Asn Leu Gly Cys Ile His Phe 
    290                 295                 300                 


Ala Met Ser Lys His Asn Leu Gly Ile Phe Tyr Phe Lys Lys Ala Leu 
305                 310                 315                 320 


Gln Glu Asn Asp Asn Val Cys Ala Gln Leu Ser Ala Gly Ser Thr Asp 
                325                 330                 335     


Pro Gly Lys Lys Phe Ser Gly Arg Pro Met Cys Thr Leu Leu Thr Asn 
            340                 345                 350         


Lys Arg Tyr Glu Leu Leu Tyr Asn Cys Gly Ile Gln Leu Leu His Ile 
        355                 360                 365             


Gly Arg Pro Leu Ala Ala Phe Glu Cys Leu Ile Glu Ala Val Gln Val 
    370                 375                 380                 


Tyr His Ala Asn Pro Arg Leu Trp Leu Arg Leu Ala Glu Cys Cys Ile 
385                 390                 395                 400 


Ala Ala Asn Lys Gly Thr Ser Glu Gln Glu Thr Lys Gly Leu Pro Ser 
                405                 410                 415     


Lys Lys Gly Ile Val Gln Ser Ile Val Gly Gln Gly Tyr His Arg Lys 
            420                 425                 430         


Ile Val Leu Ala Ser Gln Ser Ile Gln Asn Thr Val Tyr Asn Asp Gly 
        435                 440                 445             


Gln Ser Ser Ala Ile Pro Val Ala Ser Met Glu Phe Ala Ala Ile Cys 
    450                 455                 460                 


Leu Arg Asn Ala Leu Leu Leu Leu Pro Glu Glu Gln Gln Asp Pro Lys 
465                 470                 475                 480 


Gln Glu Asn Gly Ala Lys Asn Ser Asn Gln Leu Gly Gly Asn Thr Glu 
                485                 490                 495     


Ser Ser Glu Ser Ser Glu Thr Cys Ser Ser Lys Ser His Asp Gly Asp 
            500                 505                 510         


Lys Phe Ile Pro Ala Pro Pro Ser Ser Pro Leu Arg Lys Gln Glu Leu 
        515                 520                 525             


Glu Asn Leu Lys Cys Ser Ile Leu Ala Cys Ser Ala Tyr Val Ala Leu 
    530                 535                 540                 


Ala Leu Gly Asp Asn Leu Met Ala Leu Asn His Ala Asp Lys Leu Leu 
545                 550                 555                 560 


Gln Gln Pro Lys Leu Ser Gly Ser Leu Lys Phe Leu Gly His Leu Tyr 
                565                 570                 575     


Ala Ala Glu Ala Leu Ile Ser Leu Asp Arg Ile Ser Asp Ala Ile Thr 
            580                 585                 590         


His Leu Asn Pro Glu Asn Val Thr Asp Val Ser Leu Gly Ile Ser Ser 
        595                 600                 605             


Asn Glu Gln Asp Gln Gly Ser Asp Lys Gly Glu Asn Glu Ala Met Glu 
    610                 615                 620                 


Ser Ser Gly Lys Arg Ala Pro Gln Cys Tyr Pro Ser Ser Val Asn Ser 
625                 630                 635                 640 


Ala Arg Thr Val Met Leu Phe Asn Leu Gly Ser Ala Tyr Cys Leu Arg 
                645                 650                 655     


Ser Glu Tyr Asp Lys Ala Arg Lys Cys Leu His Gln Ala Ala Ser Met 
            660                 665                 670         


Ile His Pro Lys Glu Val Pro Pro Glu Ala Ile Leu Leu Ala Val Tyr 
        675                 680                 685             


Leu Glu Leu Gln Asn Gly Asn Thr Gln Leu Ala Leu Gln Ile Ile Lys 
    690                 695                 700                 


Arg Asn Gln Leu Leu Pro Ala Val Lys Thr His Ser Glu Val Arg Lys 
705                 710                 715                 720 


Lys Pro Val Phe Gln Pro Val His Pro Ile Gln Pro Ile Gln Met Pro 
                725                 730                 735     


Ala Phe Thr Thr Val Gln Arg Lys 
            740                 


<210>  251
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ala Gly Glu Glu Ile Asn Glu Asp Tyr Pro Val Glu Ile His Glu 
1               5                   10                  15      


Tyr Leu Ser Ala Phe Glu Asn Ser Ile Gly Ala Val Asp Glu Met Leu 
            20                  25                  30          


Lys Thr Met Met Ser Val Ser Arg Asn Glu Leu Leu Gln Lys Leu Asp 
        35                  40                  45              


Pro Leu Glu Gln Ala Lys Val Asp Leu Val Ser Ala Tyr Thr Leu Asn 
    50                  55                  60                  


Ser Met Phe Trp Val Tyr Leu Ala Thr Gln Gly Val Asn Pro Lys Glu 
65                  70                  75                  80  


His Pro Val Lys Gln Glu Leu Glu Arg Ile Arg Val Tyr Met Asn Arg 
                85                  90                  95      


Val Lys Glu Ile Thr Asp Lys Lys Lys Ala Gly Lys Leu Asp Arg Gly 
            100                 105                 110         


Ala Ala Ser Arg Phe Val Lys Asn Ala Leu Trp Glu Pro Lys Ser Lys 
        115                 120                 125             


Asn Ala Ser Lys Val Ala Asn Lys Gly Lys Ser Lys Ser 
    130                 135                 140     


<210>  252
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  253
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Ala Ser Val Thr Leu Ser Glu Ala Glu Lys Val Tyr Ile Val His 
1               5                   10                  15      


Gly Val Gln Glu Asp Leu Arg Val Asp Gly Arg Gly Cys Glu Asp Tyr 
            20                  25                  30          


Arg Cys Val Glu Val Glu Thr Asp Val Val Ser Asn Thr Ser Gly Ser 
        35                  40                  45              


Ala Arg Val Lys Leu Gly His Thr Asp Ile Leu Val Gly Val Lys Ala 
    50                  55                  60                  


Glu Met Gly Thr Pro Lys Leu Glu Lys Pro Asn Glu Gly Tyr Leu Glu 
65                  70                  75                  80  


Phe Phe Val Asp Cys Ser Ala Ser Ala Thr Pro Glu Phe Glu Gly Arg 
                85                  90                  95      


Gly Gly Asp Asp Leu Gly Thr Glu Ile Ala Asn Thr Leu Tyr Arg Ile 
            100                 105                 110         


Phe Asn Asn Lys Ser Ser Val Asp Leu Lys Thr Leu Cys Ile Ser Pro 
        115                 120                 125             


Arg Glu His Cys Trp Val Leu Tyr Val Asp Val Leu Leu Leu Glu Cys 
    130                 135                 140                 


Gly Gly Asn Leu Phe Asp Ala Ile Ser Ile Ala Val Lys Ala Ala Leu 
145                 150                 155                 160 


Phe Asn Thr Arg Ile Pro Arg Val Arg Val Leu Glu Asp Glu Glu Gly 
                165                 170                 175     


Ser Lys Asp Ile Glu Leu Ser Asp Asp Pro Tyr Asp Cys Ile Arg Leu 
            180                 185                 190         


Ser Val Glu Asn Val Pro Cys Ile Val Thr Leu Cys Lys Ile Gly Tyr 
        195                 200                 205             


Arg His Val Val Asp Ala Thr Leu Gln Glu Glu Ala Cys Ser Leu Ala 
    210                 215                 220                 


Ser Leu Leu Val Ser Val Thr Ser Lys Gly Val Val Thr Cys Met Arg 
225                 230                 235                 240 


Lys Val Gly Lys Gly Ser Leu Asp Pro Glu Ser Ile Phe Glu Met Met 
                245                 250                 255     


Glu Thr Gly Lys Arg Val Gly Lys Val Leu His Ala Ser Leu Gln Ser 
            260                 265                 270         


Val Val His Lys Glu Glu Ser Leu Gly Pro Lys Arg Gln Lys Val Gly 
        275                 280                 285             


Phe Leu Gly 
    290     


<210>  254
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Ala Met Glu Met Arg Leu Pro Val Ala Arg Lys Pro Leu Ser Glu 
1               5                   10                  15      


Arg Leu Gly Arg Asp Thr Lys Lys His Leu Val Val Pro Gly Asp Thr 
            20                  25                  30          


Ile Thr Thr Asp Thr Gly Phe Met Arg Gly His Gly Thr Tyr Met Gly 
        35                  40                  45              


Glu Glu Lys Leu Ile Ala Ser Val Ala Gly Ser Val Glu Arg Val Asn 
    50                  55                  60                  


Lys Leu Ile Cys Val Lys Ala Leu Lys Thr Arg Tyr Ile Gly Glu Val 
65                  70                  75                  80  


Gly Asp Ile Val Val Gly Arg Ile Thr Glu Val Gln Gln Lys Arg Trp 
                85                  90                  95      


Lys Val Glu Thr Asn Ser Arg Leu Asp Ser Val Leu Leu Leu Ser Ser 
            100                 105                 110         


Met Asn Leu Pro Gly Gly Glu Leu Arg Arg Arg Ser Ala Glu Asp Glu 
        115                 120                 125             


Leu Ala Met Arg Gly Phe Leu Gln Glu Gly Asp Leu Ile Ser Ala Glu 
    130                 135                 140                 


Val Gln Ala Val Phe Ser Asp Gly Ala Val Ser Leu His Thr Arg Ser 
145                 150                 155                 160 


Leu Lys Tyr Gly Lys Leu Gly Gln Gly Val Leu Val Gln Val Ser Pro 
                165                 170                 175     


Ser Leu Val Lys Arg Gln Lys Thr His Phe His Asp Leu Pro Cys Gly 
            180                 185                 190         


Ala Ser Val Ile Leu Gly Asn Asn Gly Phe Ile Trp Ile Tyr Pro Thr 
        195                 200                 205             


Pro Glu His Lys Glu Glu Glu Ala Gly Gly Phe Ile Ala Asn Leu Glu 
    210                 215                 220                 


Pro Val Ser Leu Ala Asp Arg Glu Val Ile Ser Arg Leu Arg Asn Cys 
225                 230                 235                 240 


Ile Ile Ser Leu Val Thr Gln Arg Met Met Leu Tyr Asp Thr Ser Ile 
                245                 250                 255     


Leu Tyr Cys Tyr Glu Ala Ser Leu Pro His Gln Ile Lys Asp Ile Leu 
            260                 265                 270         


Lys Pro Glu Ile Met Glu Glu Ile Val Met Glu Thr Arg Gln Arg Leu 
        275                 280                 285             


Leu Glu Gln Glu Gly 
    290             


<210>  255
<211>  958
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Leu Lys Ser Lys Thr Phe Leu Lys Lys Thr Arg Ala Gly Gly Val 
1               5                   10                  15      


Met Lys Ile Val Arg Glu His Tyr Leu Arg Asp Asp Ile Gly Cys Gly 
            20                  25                  30          


Ala Pro Gly Cys Ala Ala Cys Gly Gly Ala His Glu Gly Pro Ala Leu 
        35                  40                  45              


Glu Pro Gln Pro Gln Asp Pro Ala Ser Ser Val Cys Pro Gln Pro His 
    50                  55                  60                  


Tyr Leu Leu Pro Asp Thr Asn Val Leu Leu His Gln Ile Asp Val Leu 
65                  70                  75                  80  


Glu Asp Pro Ala Ile Arg Asn Val Ile Val Leu Gln Thr Val Leu Gln 
                85                  90                  95      


Glu Val Arg Asn Arg Ser Ala Pro Val Tyr Lys Arg Ile Arg Asp Val 
            100                 105                 110         


Thr Asn Asn Gln Glu Lys His Phe Tyr Thr Phe Thr Asn Glu His His 
        115                 120                 125             


Arg Glu Thr Tyr Val Glu Gln Glu Gln Gly Glu Asn Ala Asn Asp Arg 
    130                 135                 140                 


Asn Asp Arg Ala Ile Arg Val Ala Ala Lys Trp Tyr Asn Glu His Leu 
145                 150                 155                 160 


Lys Lys Met Ser Ala Asp Asn Gln Leu Gln Val Ile Phe Ile Thr Asn 
                165                 170                 175     


Asp Arg Arg Asn Lys Glu Lys Ala Ile Glu Glu Gly Ile Pro Ala Phe 
            180                 185                 190         


Thr Cys Glu Glu Tyr Val Lys Ser Leu Thr Ala Asn Pro Glu Leu Ile 
        195                 200                 205             


Asp Arg Leu Ala Cys Leu Ser Glu Glu Gly Asn Glu Ile Glu Ser Gly 
    210                 215                 220                 


Lys Ile Ile Phe Ser Glu His Leu Pro Leu Ser Lys Leu Gln Gln Gly 
225                 230                 235                 240 


Ile Lys Ser Gly Thr Tyr Leu Gln Gly Thr Phe Arg Ala Ser Arg Glu 
                245                 250                 255     


Asn Tyr Leu Glu Ala Thr Val Trp Ile His Gly Asp Asn Glu Glu Asn 
            260                 265                 270         


Lys Glu Ile Ile Leu Gln Gly Leu Lys His Leu Asn Arg Ala Val His 
        275                 280                 285             


Glu Asp Ile Val Ala Val Glu Leu Leu Pro Lys Ser Gln Trp Val Ala 
    290                 295                 300                 


Pro Ser Ser Val Val Leu His Asp Glu Gly Gln Asn Glu Glu Asp Val 
305                 310                 315                 320 


Glu Lys Glu Glu Glu Thr Glu Arg Met Leu Lys Thr Ala Val Ser Glu 
                325                 330                 335     


Lys Met Leu Lys Pro Thr Gly Arg Val Val Gly Ile Ile Lys Arg Asn 
            340                 345                 350         


Trp Arg Pro Tyr Cys Gly Met Leu Ser Lys Ser Asp Ile Lys Glu Ser 
        355                 360                 365             


Arg Arg His Leu Phe Thr Pro Ala Asp Lys Arg Ile Pro Arg Ile Arg 
    370                 375                 380                 


Ile Glu Thr Arg Gln Ala Ser Thr Leu Glu Gly Arg Arg Ile Ile Val 
385                 390                 395                 400 


Ala Ile Asp Gly Trp Pro Arg Asn Ser Arg Tyr Pro Asn Gly His Phe 
                405                 410                 415     


Val Arg Asn Leu Gly Asp Val Gly Glu Lys Glu Thr Glu Thr Glu Val 
            420                 425                 430         


Leu Leu Leu Glu His Asp Val Pro His Gln Pro Phe Ser Gln Ala Val 
        435                 440                 445             


Leu Ser Phe Leu Pro Lys Met Pro Trp Ser Ile Thr Glu Lys Asp Met 
    450                 455                 460                 


Lys Asn Arg Glu Asp Leu Arg His Leu Cys Ile Cys Ser Val Asp Pro 
465                 470                 475                 480 


Pro Gly Cys Thr Asp Ile Asp Asp Ala Leu His Cys Arg Glu Leu Glu 
                485                 490                 495     


Asn Gly Asn Leu Glu Val Gly Val His Ile Ala Asp Val Ser His Phe 
            500                 505                 510         


Ile Arg Pro Gly Asn Ala Leu Asp Gln Glu Ser Ala Arg Arg Gly Thr 
        515                 520                 525             


Thr Val Tyr Leu Cys Glu Lys Arg Ile Asp Met Val Pro Glu Leu Leu 
    530                 535                 540                 


Ser Ser Asn Leu Cys Ser Leu Lys Cys Asp Val Asp Arg Leu Ala Phe 
545                 550                 555                 560 


Ser Cys Ile Trp Glu Met Asn His Asn Ala Glu Ile Leu Lys Thr Lys 
                565                 570                 575     


Phe Thr Lys Ser Val Ile Asn Ser Lys Ala Ser Leu Thr Tyr Ala Glu 
            580                 585                 590         


Ala Gln Leu Arg Ile Asp Ser Ala Asn Met Asn Asp Asp Ile Thr Thr 
        595                 600                 605             


Ser Leu Arg Gly Leu Asn Lys Leu Ala Lys Ile Leu Lys Lys Arg Arg 
    610                 615                 620                 


Ile Glu Lys Gly Ala Leu Thr Leu Ser Ser Pro Glu Val Arg Phe His 
625                 630                 635                 640 


Met Asp Ser Glu Thr His Asp Pro Ile Asp Leu Gln Thr Lys Glu Leu 
                645                 650                 655     


Arg Glu Thr Asn Ser Met Val Glu Glu Phe Met Leu Leu Ala Asn Ile 
            660                 665                 670         


Ser Val Ala Lys Lys Ile His Glu Glu Phe Ser Glu His Ala Leu Leu 
        675                 680                 685             


Arg Lys His Pro Ala Pro Pro Pro Ser Asn Tyr Glu Ile Leu Val Lys 
    690                 695                 700                 


Ala Ala Arg Ser Arg Asn Leu Glu Ile Lys Thr Asp Thr Ala Lys Ser 
705                 710                 715                 720 


Leu Ala Glu Ser Leu Asp Gln Ala Glu Ser Pro Thr Phe Pro Tyr Leu 
                725                 730                 735     


Asn Thr Leu Leu Arg Ile Leu Ala Thr Arg Cys Met Met Gln Ala Val 
            740                 745                 750         


Tyr Phe Cys Ser Gly Met Asp Asn Asp Phe His His Tyr Gly Leu Ala 
        755                 760                 765             


Ser Pro Ile Tyr Thr His Phe Thr Ser Pro Ile Arg Arg Tyr Ala Asp 
    770                 775                 780                 


Val Ile Val His Arg Leu Leu Ala Val Ala Ile Gly Ala Asp Cys Thr 
785                 790                 795                 800 


Tyr Pro Glu Leu Thr Asp Lys His Lys Leu Ala Asp Ile Cys Lys Asn 
                805                 810                 815     


Leu Asn Phe Arg His Lys Met Ala Gln Tyr Ala Gln Arg Ala Ser Val 
            820                 825                 830         


Ala Phe His Thr Gln Leu Phe Phe Lys Ser Lys Gly Ile Val Ser Glu 
        835                 840                 845             


Glu Ala Tyr Ile Leu Phe Val Arg Lys Asn Ala Ile Val Val Leu Ile 
    850                 855                 860                 


Pro Lys Tyr Gly Leu Glu Gly Thr Val Phe Phe Glu Glu Lys Asp Lys 
865                 870                 875                 880 


Pro Asn Pro Gln Leu Ile Tyr Asp Asp Glu Ile Pro Ser Leu Lys Ile 
                885                 890                 895     


Glu Asp Thr Val Phe His Val Phe Asp Lys Val Lys Val Lys Ile Met 
            900                 905                 910         


Leu Asp Ser Ser Asn Leu Gln His Gln Lys Ile Arg Met Ser Leu Val 
        915                 920                 925             


Glu Pro Gln Ile Pro Gly Ile Ser Ile Pro Thr Asp Thr Ser Asn Met 
    930                 935                 940                 


Asp Leu Asn Gly Pro Lys Lys Lys Lys Met Lys Leu Gly Lys 
945                 950                 955             


<210>  256
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ala Ala Leu Gly Gly Asp Gly Leu Arg Leu Leu Ser Val Ser Arg 
1               5                   10                  15      


Pro Glu Arg Pro Pro Glu Ser Ala Ala Leu Gly Gly Leu Gly Pro Gly 
            20                  25                  30          


Leu Cys Cys Trp Val Ser Val Phe Ser Cys Leu Ser Leu Ala Cys Ser 
        35                  40                  45              


Tyr Val Gly Ser Leu Tyr Val Trp Lys Ser Glu Leu Pro Arg Asp His 
    50                  55                  60                  


Pro Ala Val Ile Lys Arg Arg Phe Thr Ser Val Leu Val Val Ser Ser 
65                  70                  75                  80  


Leu Ser Pro Leu Cys Val Leu Leu Trp Arg Glu Leu Thr Gly Ile Gln 
                85                  90                  95      


Pro Gly Thr Ser Leu Leu Thr Leu Met Gly Phe Arg Leu Glu Gly Ile 
            100                 105                 110         


Phe Pro Ala Ala Leu Leu Pro Leu Leu Leu Thr Met Ile Leu Phe Leu 
        115                 120                 125             


Gly Pro Leu Met Gln Leu Ser Met Asp Cys Pro Cys Asp Leu Ala Asp 
    130                 135                 140                 


Gly Leu Lys Val Val Leu Ala Pro Arg Ser Trp Ala Arg Cys Leu Thr 
145                 150                 155                 160 


Asp Met Arg Trp Leu Arg Asn Gln Val Ile Ala Pro Leu Thr Glu Glu 
                165                 170                 175     


Leu Val Phe Arg Ala Cys Met Leu Pro Met Leu Ala Pro Cys Met Gly 
            180                 185                 190         


Leu Gly Pro Ala Val Phe Thr Cys Pro Leu Phe Phe Gly Val Ala His 
        195                 200                 205             


Phe His His Ile Ile Glu Gln Leu Arg Phe Arg Gln Ser Ser Val Gly 
    210                 215                 220                 


Asn Ile Phe Leu Ser Ala Ala Phe Gln Phe Ser Tyr Thr Ala Val Phe 
225                 230                 235                 240 


Gly Ala Tyr Thr Ala Phe Leu Phe Ile Arg Thr Gly His Leu Ile Gly 
                245                 250                 255     


Pro Val Leu Cys His Ser Phe Cys Asn Tyr Met Gly Phe Pro Ala Val 
            260                 265                 270         


Cys Ala Ala Leu Glu His Pro Gln Arg Arg Pro Leu Leu Ala Gly Tyr 
        275                 280                 285             


Ala Leu Gly Val Gly Leu Phe Leu Leu Leu Leu Gln Pro Leu Thr Asp 
    290                 295                 300                 


Pro Lys Leu Tyr Gly Ser Leu Pro Leu Cys Val Leu Leu Glu Arg Ala 
305                 310                 315                 320 


Gly Asp Ser Glu Ala Pro Leu Cys Ser 
                325                 


<210>  257
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Thr Gly Leu Tyr Glu Leu Val Trp Arg Val Leu His Ala Leu Leu 
1               5                   10                  15      


Cys Leu His Arg Thr Leu Thr Ser Trp Leu Arg Val Arg Phe Gly Thr 
            20                  25                  30          


Trp Asn Trp Ile Trp Arg Arg Cys Cys Arg Ala Ala Ser Ala Ala Val 
        35                  40                  45              


Leu Ala Pro Leu Gly Phe Thr Leu Arg Lys Pro Pro Ala Val Gly Arg 
    50                  55                  60                  


Asn Arg Arg His His Arg His Pro Arg Gly Gly Ser Cys Leu Ala Ala 
65                  70                  75                  80  


Ala His His Arg Met Arg Trp Arg Ala Asp Gly Arg Ser Leu Glu Lys 
                85                  90                  95      


Leu Pro Val His Met Gly Leu Val Ile Thr Glu Val Glu Gln Glu Pro 
            100                 105                 110         


Ser Phe Ser Asp Ile Ala Ser Leu Val Val Trp Cys Met Ala Val Gly 
        115                 120                 125             


Ile Ser Tyr Ile Ser Val Tyr Asp His Gln Gly Ile Phe Lys Arg Asn 
    130                 135                 140                 


Asn Ser Arg Leu Met Asp Glu Ile Leu Lys Gln Gln Gln Glu Leu Leu 
145                 150                 155                 160 


Gly Leu Asp Cys Ser Lys Tyr Ser Pro Glu Phe Ala Asn Ser Asn Asp 
                165                 170                 175     


Lys Asp Asp Gln Val Leu Asn Cys His Leu Ala Val Lys Val Leu Ser 
            180                 185                 190         


Pro Glu Asp Gly Lys Ala Asp Ile Val Arg Ala Ala Gln Asp Phe Cys 
        195                 200                 205             


Gln Leu Val Ala Gln Lys Gln Lys Arg Pro Thr Asp Leu Asp Val Asp 
    210                 215                 220                 


Thr Leu Ala Ser Leu Leu Ser Ser Asn Gly Cys Pro Asp Pro Asp Leu 
225                 230                 235                 240 


Val Leu Lys Phe Gly Pro Val Asp Ser Thr Leu Gly Phe Leu Pro Trp 
                245                 250                 255     


His Ile Arg Leu Thr Glu Ile Val Ser Leu Pro Ser His Leu Asn Ile 
            260                 265                 270         


Ser Tyr Glu Asp Phe Phe Ser Ala Leu Arg Gln Tyr Ala Ala Cys Glu 
        275                 280                 285             


Gln Arg Leu Gly Lys 
    290             


<210>  258
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Pro Glu Ile Asn Thr Asn His Leu Asp Lys Gln Gln Val Gln Leu 
1               5                   10                  15      


Leu Ala Glu Met Cys Ile Leu Ile Asp Glu Asn Asp Asn Lys Ile Gly 
            20                  25                  30          


Ala Glu Thr Lys Lys Asn Cys His Leu Asn Glu Asn Ile Glu Lys Gly 
        35                  40                  45              


Leu Leu His Arg Ala Phe Ser Val Phe Leu Phe Asn Thr Glu Asn Lys 
    50                  55                  60                  


Leu Leu Leu Gln Gln Arg Ser Asp Ala Lys Ile Thr Phe Pro Gly Cys 
65                  70                  75                  80  


Phe Thr Asn Thr Cys Cys Ser His Pro Leu Ser Asn Pro Ala Glu Leu 
                85                  90                  95      


Glu Glu Ser Asp Ala Leu Gly Val Arg Arg Ala Ala Gln Arg Arg Leu 
            100                 105                 110         


Lys Ala Glu Leu Gly Ile Pro Leu Glu Glu Val Pro Pro Glu Glu Ile 
        115                 120                 125             


Asn Tyr Leu Thr Arg Ile His Tyr Lys Ala Gln Ser Asp Gly Ile Trp 
    130                 135                 140                 


Gly Glu His Glu Ile Asp Tyr Ile Leu Leu Val Arg Lys Asn Val Thr 
145                 150                 155                 160 


Leu Asn Pro Asp Pro Asn Glu Ile Lys Ser Tyr Cys Tyr Val Ser Lys 
                165                 170                 175     


Glu Glu Leu Lys Glu Leu Leu Lys Lys Ala Ala Ser Gly Glu Ile Lys 
            180                 185                 190         


Ile Thr Pro Trp Phe Lys Ile Ile Ala Ala Thr Phe Leu Phe Lys Trp 
        195                 200                 205             


Trp Asp Asn Leu Asn His Leu Asn Gln Phe Val Asp His Glu Lys Ile 
    210                 215                 220                 


Tyr Arg Met 
225         


<210>  259
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Ala Ser Glu Lys Pro Leu Ala Ala Val Thr Cys Thr Ala Pro Val 
1               5                   10                  15      


Asn Ile Ala Val Ile Lys Tyr Trp Gly Lys Arg Asp Glu Glu Leu Val 
            20                  25                  30          


Leu Pro Ile Asn Ser Ser Leu Ser Val Thr Leu His Gln Asp Gln Leu 
        35                  40                  45              


Lys Thr Thr Thr Thr Ala Val Ile Ser Lys Asp Phe Thr Glu Asp Arg 
    50                  55                  60                  


Ile Trp Leu Asn Gly Arg Glu Glu Asp Val Gly Gln Pro Arg Leu Gln 
65                  70                  75                  80  


Ala Cys Leu Arg Glu Ile Arg Cys Leu Ala Arg Lys Arg Arg Asn Ser 
                85                  90                  95      


Arg Asp Gly Asp Pro Leu Pro Ser Ser Leu Ser Cys Lys Val His Val 
            100                 105                 110         


Ala Ser Val Asn Asn Phe Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala 
        115                 120                 125             


Ala Gly Tyr Ala Cys Leu Ala Tyr Thr Leu Ala Arg Val Tyr Gly Val 
    130                 135                 140                 


Glu Ser Asp Leu Ser Glu Val Ala Arg Arg Gly Ser Gly Ser Ala Cys 
145                 150                 155                 160 


Arg Ser Leu Tyr Gly Gly Phe Val Glu Trp Gln Met Gly Glu Gln Ala 
                165                 170                 175     


Asp Gly Lys Asp Ser Ile Ala Arg Gln Val Ala Pro Glu Ser His Trp 
            180                 185                 190         


Pro Glu Leu Arg Val Leu Ile Leu Val Val Ser Ala Glu Lys Lys Leu 
        195                 200                 205             


Thr Gly Ser Thr Val Gly Met Arg Ala Ser Val Glu Thr Ser Pro Leu 
    210                 215                 220                 


Leu Arg Phe Arg Ala Glu Ser Val Val Pro Ala Arg Met Ala Glu Met 
225                 230                 235                 240 


Ala Arg Cys Ile Arg Glu Arg Asp Phe Pro Ser Phe Ala Gln Leu Thr 
                245                 250                 255     


Met Lys Asp Ser Asn Gln Phe His Ala Thr Cys Leu Asp Thr Phe Pro 
            260                 265                 270         


Pro Ile Ser Tyr Leu Asn Ala Ile Ser Trp Arg Ile Ile His Leu Val 
        275                 280                 285             


His Arg Phe Asn Ala His His Gly Asp Thr Lys Val Ala Tyr Thr Phe 
    290                 295                 300                 


Asp Ala Gly Pro Asn Ala Val Ile Phe Thr Leu Asp Asp Thr Val Ala 
305                 310                 315                 320 


Glu Phe Val Ala Ala Val Trp His Gly Phe Pro Pro Gly Ser Asn Gly 
                325                 330                 335     


Asp Thr Phe Leu Lys Gly Leu Gln Val Arg Pro Ala Pro Leu Ser Ala 
            340                 345                 350         


Glu Leu Gln Ala Ala Leu Ala Met Glu Pro Thr Pro Gly Gly Val Lys 
        355                 360                 365             


Tyr Ile Ile Val Thr Gln Val Gly Pro Gly Pro Gln Ile Leu Asp Asp 
    370                 375                 380                 


Pro Cys Ala His Leu Leu Gly Pro Asp Gly Leu Pro Lys Pro Ala Ala 
385                 390                 395                 400 


