                         SEQUENCE LISTING

<110>  Johns Hopkins Technology Ventures
 
<120>  MODULAR, INDUCIBLE REPRESSORS FOR THE

<130>  P14178-02

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  1
aattgtgagc ggataacaat t                                                 21


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  2
tctttttatg atgtggcgta atc                                               23


<210>  3
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  3

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
                85                  90                  95      


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile 
            100                 105                 110         


Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg 
        115                 120                 125             


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val 
    130                 135                 140                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                165                 170                 175     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            180                 185                 190         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        195                 200                 205             


Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    210                 215                 220                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
225                 230                 235                 240 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                245                 250                 255     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            260                 265                 270         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        275                 280                 285             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    290                 295                 300                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn 
305                 310                 315                 320 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                325                 330                 335     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            340                 345                 350         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        355                 360                 365             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    370                 375                 380                 


Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
385                 390                 395                 400 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
                405                 410                 415     


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            420                 425                 430         


Arg Leu Leu Pro Val Leu Ala Asp Leu Pro Gly Lys Gly Ile Thr Val 
        435                 440                 445             


Asn Pro Val Gln Ser Thr Ile Thr Glu Glu Thr Phe Gln Thr Leu Leu 
    450                 455                 460                 


Val Ser Arg Ala Leu Glu Lys Leu Gly Tyr Thr Val Asn Lys Pro Ser 
465                 470                 475                 480 


Glu Val Asp Tyr Asn Val Gly Tyr Thr Ser Leu Ala Ser Gly Asp Ala 
                485                 490                 495     


Thr Phe Thr Ala Val Asn Trp Thr Pro Leu His Asp Asn Met Tyr Glu 
            500                 505                 510         


Ala Ala Gly Gly Asp Lys Lys Phe Tyr Arg Glu Gly Val Phe Val Asn 
        515                 520                 525             


Gly Ala Ala Gln Gly Tyr Leu Ile Asp Lys Lys Thr Ala Asp Gln Tyr 
    530                 535                 540                 


Lys Ile Thr Asn Ile Ala Gln Leu Lys Asp Pro Lys Ile Ala Lys Leu 
545                 550                 555                 560 


Phe Asp Thr Asn Gly Asp Gly Lys Ala Asp Leu Thr Gly Cys Asn Pro 
                565                 570                 575     


Gly Trp Gly Cys Glu Gly Ala Ile Asn His Gln Leu Ala Ala Tyr Glu 
            580                 585                 590         


Leu Thr Asn Thr Val Thr His Asn Gln Gly Asn Tyr Ala Ala Met Met 
        595                 600                 605             


Ala Asp Thr Ile Ser Arg Tyr Lys Glu Gly Lys Pro Val Phe Tyr Tyr 
    610                 615                 620                 


Thr Trp Thr Pro Tyr Trp Val Ser Asn Glu Leu Lys Pro Gly Lys Asp 
625                 630                 635                 640 


Val Val Trp Leu Gln Val Pro Phe Ser Ala Leu Pro Gly Asp Lys Asn 
                645                 650                 655     


Ala Asp Thr Lys Leu Pro Asn Gly Ala Asn Tyr Gly Phe Pro Val Ser 
            660                 665                 670         


Thr Met His Ile Val Ala Asn Lys Ala Trp Ala Glu Lys Asn Pro Ala 
        675                 680                 685             


Ala Ala Lys Leu Phe Ala Ile Met Gln Leu Pro Val Ala Asp Ile Asn 
    690                 695                 700                 


Ala Gln Asn Ala Ile Met His Asp Gly Lys Ala Ser Glu Gly Asp Ile 
705                 710                 715                 720 


Gln Gly His Val Asp Gly Trp Ile Lys Ala His Gln Gln Gln Phe Asp 
                725                 730                 735     


Gly Trp Val Asn Glu Ala Leu Ala Ala Gln Lys Cys Gln Ala His Gly 
            740                 745                 750         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        755                 760                 765             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    770                 775                 780                 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
785                 790                 795                 800 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                805                 810                 815     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            820                 825                 830         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        835                 840                 845             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    850                 855                 860                 


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
865                 870                 875                 880 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                885                 890                 895     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            900                 905                 910         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        915                 920                 925             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    930                 935                 940                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
945                 950                 955                 960 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                965                 970                 975     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            980                 985                 990         


Pro Glu Gln Val Val Ala Ile Ala  Ser Asn Gly Gly Gly  Lys Gln Ala 
        995                 1000                 1005             


Leu Glu  Thr Val Gln Arg Leu  Leu Pro Val Leu Cys  Gln Ala His 
    1010                 1015                 1020             


Gly Leu  Thr Pro Glu Gln Val  Val Ala Ile Ala Ser  Asn Gly Gly 
    1025                 1030                 1035             


Gly Arg  Pro Ala Leu Glu Ser  Ile Val Ala Gln Leu  Ser Arg Pro 
    1040                 1045                 1050             


Asp Pro  Ala Leu Ala Ala Leu  Thr Asn Asp His Leu  Val Ala Leu 
    1055                 1060                 1065             


Ala Cys  Leu Gly Gly Arg Pro  Ala Leu Asp Ala Val  Lys Lys Gly 
    1070                 1075                 1080             


Leu Pro  His Ala Pro Ala Leu  Ile Lys Arg Thr Asn  Arg Arg Ile 
    1085                 1090                 1095             


Pro Glu  Arg Thr Ser His Arg  Val Ala Asp His Ala  Gln Val Val 
    1100                 1105                 1110             


Arg Val  Leu Gly Phe Phe Gln  Cys His Ser His Pro  Ala Gln Ala 
    1115                 1120                 1125             


Phe Asp  Asp Ala Met Thr Gln  Phe Gly Met Ser Asp  Tyr Lys Asp 
    1130                 1135                 1140             


Asp Asp  Asp Lys 
    1145         


<210>  4
<211>  1152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
                85                  90                  95      


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile 
            100                 105                 110         


Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg 
        115                 120                 125             


Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val 
    130                 135                 140                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
                165                 170                 175     


Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr 
            180                 185                 190         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        195                 200                 205             


Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
    210                 215                 220                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
225                 230                 235                 240 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln 
                245                 250                 255     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            260                 265                 270         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        275                 280                 285             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    290                 295                 300                 


Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn 
305                 310                 315                 320 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                325                 330                 335     


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
            340                 345                 350         


His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        355                 360                 365             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
    370                 375                 380                 


Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
385                 390                 395                 400 


Leu Pro Val Leu Cys Gln Ala Pro Ser Glu Val Asp Tyr Asn Val Gly 
                405                 410                 415     


Tyr Thr Ser Leu Ala Ser Gly Asp Ala Thr Phe Thr Ala Val Asn Trp 
            420                 425                 430         


Thr Pro Leu His Asp Asn Met Tyr Glu Ala Ala Gly Gly Asp Lys Lys 
        435                 440                 445             


Phe Tyr Arg Glu Gly Val Phe Val Asn Gly Ala Ala Gln Gly Tyr Leu 
    450                 455                 460                 


Ile Asp Lys Lys Thr Ala Asp Gln Tyr Lys Ile Thr Asn Ile Ala Gln 
465                 470                 475                 480 


Leu Lys Asp Pro Lys Ile Ala Lys Leu Phe Asp Thr Asn Gly Asp Gly 
                485                 490                 495     


Lys Ala Asp Leu Thr Gly Cys Asn Pro Gly Trp Gly Cys Glu Gly Ala 
            500                 505                 510         


Ile Asn His Gln Leu Ala Ala Tyr Glu Leu Thr Asn Thr Val Thr His 
        515                 520                 525             


Asn Gln Gly Asn Tyr Ala Ala Met Met Ala Asp Thr Ile Ser Arg Tyr 
    530                 535                 540                 


Lys Glu Gly Lys Pro Val Phe Tyr Tyr Thr Trp Thr Pro Tyr Trp Val 
545                 550                 555                 560 


Ser Asn Glu Leu Lys Pro Gly Lys Asp Val Val Trp Leu Gln Val Pro 
                565                 570                 575     


Phe Ser Ala Leu Pro Gly Asp Lys Asn Ala Asp Thr Lys Leu Pro Asn 
            580                 585                 590         


Gly Ala Asn Tyr Gly Phe Pro Val Ser Thr Met His Ile Val Ala Asn 
        595                 600                 605             


Lys Ala Trp Ala Glu Lys Asn Pro Ala Ala Ala Lys Leu Phe Ala Ile 
    610                 615                 620                 


Met Gln Leu Pro Val Ala Asp Ile Asn Ala Gln Asn Ala Ile Met His 
625                 630                 635                 640 


Asp Gly Lys Ala Ser Glu Gly Asp Ile Gln Gly His Val Asp Gly Trp 
                645                 650                 655     


Ile Lys Ala His Gln Gln Gln Phe Asp Gly Trp Val Asn Glu Ala Leu 
            660                 665                 670         


Ala Ala Gln Lys Gly Ser Gly Gly Ala Asp Leu Pro Gly Lys Gly Ile 
        675                 680                 685             


Thr Val Asn Pro Val Gln Ser Thr Ile Thr Glu Glu Thr Phe Gln Thr 
    690                 695                 700                 


Leu Leu Val Ser Arg Ala Leu Glu Lys Leu Gly Tyr Thr Val Asn Lys 
705                 710                 715                 720 


Tyr His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn 
                725                 730                 735     


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
            740                 745                 750         


Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser 
        755                 760                 765             


Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
    770                 775                 780                 


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
785                 790                 795                 800 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
                805                 810                 815     


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val 
            820                 825                 830         


Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
        835                 840                 845             


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
    850                 855                 860                 


Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr 
865                 870                 875                 880 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
                885                 890                 895     


Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu 
            900                 905                 910         


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
        915                 920                 925             


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
    930                 935                 940                 


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
945                 950                 955                 960 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
                965                 970                 975     


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
            980                 985                 990         


Ala His Gly Leu Thr Pro Glu Gln  Val Val Ala Ile Ala  Ser Asn Gly 
        995                 1000                 1005             


Gly Gly  Lys Gln Ala Leu Glu  Thr Val Gln Arg Leu  Leu Pro Val 
    1010                 1015                 1020             


Leu Cys  Gln Ala His Gly Leu  Thr Pro Glu Gln Val  Val Ala Ile 
    1025                 1030                 1035             


Ala Ser  Asn Gly Gly Gly Arg  Pro Ala Leu Glu Ser  Ile Val Ala 
    1040                 1045                 1050             


Gln Leu  Ser Arg Pro Asp Pro  Ala Leu Ala Ala Leu  Thr Asn Asp 
    1055                 1060                 1065             


His Leu  Val Ala Leu Ala Cys  Leu Gly Gly Arg Pro  Ala Leu Asp 
    1070                 1075                 1080             


Ala Val  Lys Lys Gly Leu Pro  His Ala Pro Ala Leu  Ile Lys Arg 
    1085                 1090                 1095             


Thr Asn  Arg Arg Ile Pro Glu  Arg Thr Ser His Arg  Val Ala Asp 
    1100                 1105                 1110             


His Ala  Gln Val Val Arg Val  Leu Gly Phe Phe Gln  Cys His Ser 
    1115                 1120                 1125             


His Pro  Ala Gln Ala Phe Asp  Asp Ala Met Thr Gln  Phe Gly Met 
    1130                 1135                 1140             


Ser Asp  Tyr Lys Asp Asp Asp  Asp Lys 
    1145                 1150         


<210>  5
<211>  1155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  5

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
                85                  90                  95      


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile 
            100                 105                 110         


Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg 
        115                 120                 125             


Asn Ala Leu Thr Gly Ala Gly Thr Glu Gly Val Phe Val Asn Gly Ala 
    130                 135                 140                 


Ala Gln Gly Tyr Leu Ile Asp Lys Lys Thr Ala Asp Gln Tyr Lys Ile 
145                 150                 155                 160 


Thr Asn Ile Ala Gln Leu Lys Asp Pro Lys Ile Ala Lys Leu Phe Asp 
                165                 170                 175     


Thr Asn Gly Asp Gly Lys Ala Asp Leu Thr Gly Cys Asn Pro Gly Trp 
            180                 185                 190         


Gly Cys Glu Gly Ala Ile Asn His Gln Leu Ala Ala Tyr Glu Leu Thr 
        195                 200                 205             


Asn Thr Val Thr His Asn Gln Gly Asn Tyr Ala Ala Met Met Ala Asp 
    210                 215                 220                 


Thr Ile Ser Arg Tyr Lys Glu Gly Lys Pro Val Phe Tyr Tyr Thr Trp 
225                 230                 235                 240 


Thr Pro Tyr Trp Val Ser Asn Glu Leu Lys Pro Gly Lys Asp Val Val 
                245                 250                 255     


Trp Leu Gln Val Pro Phe Ser Ala Leu Pro Gly Asp Lys Asn Ala Asp 
            260                 265                 270         


Thr Lys Leu Pro Asn Gly Ala Asn Tyr Gly Phe Pro Val Ser Thr Met 
        275                 280                 285             


His Ile Val Ala Asn Lys Ala Trp Ala Glu Lys Asn Pro Ala Ala Ala 
    290                 295                 300                 


Lys Leu Phe Ala Ile Met Gln Leu Pro Val Ala Asp Ile Asn Ala Gln 
305                 310                 315                 320 


Asn Ala Ile Met His Asp Gly Lys Ala Ser Glu Gly Asp Ile Gln Gly 
                325                 330                 335     


His Val Asp Gly Trp Ile Lys Ala His Gln Gln Gln Phe Asp Gly Trp 
            340                 345                 350         


Val Asn Glu Ala Leu Ala Ala Gln Lys Gly Ser Gly Gly Ala Asp Leu 
        355                 360                 365             


Pro Gly Lys Gly Ile Thr Val Asn Pro Val Gln Ser Thr Ile Thr Glu 
    370                 375                 380                 


Glu Thr Phe Gln Thr Leu Leu Val Ser Arg Ala Leu Glu Lys Leu Gly 
385                 390                 395                 400 


Tyr Thr Val Asn Lys Pro Ser Glu Val Asp Tyr Asn Val Gly Tyr Thr 
                405                 410                 415     


Ser Leu Ala Ser Gly Asp Ala Thr Phe Thr Ala Val Asn Trp Thr Pro 
            420                 425                 430         


Leu His Asp Asn Met Tyr Glu Ala Ala Gly Gly Asp Lys Lys Phe Tyr 
        435                 440                 445             


Arg Arg His Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    530                 535                 540                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                565                 570                 575     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            580                 585                 590         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
        595                 600                 605             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    610                 615                 620                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
625                 630                 635                 640 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                645                 650                 655     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            660                 665                 670         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        675                 680                 685             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    690                 695                 700                 


His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
705                 710                 715                 720 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                725                 730                 735     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            740                 745                 750         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        755                 760                 765             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    770                 775                 780                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
785                 790                 795                 800 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
                805                 810                 815     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            820                 825                 830         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        835                 840                 845             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    850                 855                 860                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
865                 870                 875                 880 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                885                 890                 895     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            900                 905                 910         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        915                 920                 925             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
    930                 935                 940                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
945                 950                 955                 960 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                965                 970                 975     


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            980                 985                 990         


Leu Cys Gln Ala His Gly Leu Thr  Pro Glu Gln Val Val  Ala Ile Ala 
        995                 1000                 1005             


Ser Asn  Gly Gly Gly Lys Gln  Ala Leu Glu Thr Val  Gln Arg Leu 
    1010                 1015                 1020             


Leu Pro  Val Leu Cys Gln Ala  His Gly Leu Thr Pro  Glu Gln Val 
    1025                 1030                 1035             


Val Ala  Ile Ala Ser Asn Gly  Gly Gly Arg Pro Ala  Leu Glu Ser 
    1040                 1045                 1050             


Ile Val  Ala Gln Leu Ser Arg  Pro Asp Pro Ala Leu  Ala Ala Leu 
    1055                 1060                 1065             


Thr Asn  Asp His Leu Val Ala  Leu Ala Cys Leu Gly  Gly Arg Pro 
    1070                 1075                 1080             


Ala Leu  Asp Ala Val Lys Lys  Gly Leu Pro His Ala  Pro Ala Leu 
    1085                 1090                 1095             


Ile Lys  Arg Thr Asn Arg Arg  Ile Pro Glu Arg Thr  Ser His Arg 
    1100                 1105                 1110             


Val Ala  Asp His Ala Gln Val  Val Arg Val Leu Gly  Phe Phe Gln 
    1115                 1120                 1125             


Cys His  Ser His Pro Ala Gln  Ala Phe Asp Asp Ala  Met Thr Gln 
    1130                 1135                 1140             


Phe Gly  Met Ser Asp Tyr Lys  Asp Asp Asp Asp Lys  
    1145                 1150                 1155 


<210>  6
<211>  1155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  6

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
                85                  90                  95      


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile 
            100                 105                 110         


Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg 
        115                 120                 125             


Asn Ala Leu Thr Gly Ala Gly Thr Glu Gly Val Phe Val Asn Gly Ala 
    130                 135                 140                 


Ala Gln Gly Tyr Leu Ile Asp Lys Lys Thr Ala Asp Gln Tyr Lys Ile 
145                 150                 155                 160 


Thr Asn Ile Ala Gln Leu Lys Asp Pro Lys Ile Ala Lys Leu Phe Asp 
                165                 170                 175     


Thr Asn Gly Asp Gly Lys Ala Asp Leu Thr Gly Cys Asn Pro Gly Trp 
            180                 185                 190         


Gly Cys Glu Gly Ala Ile Asn His Gln Leu Ala Ala Tyr Glu Leu Thr 
        195                 200                 205             


Asn Thr Val Thr His Asn Gln Gly Asn Tyr Ala Ala Met Met Ala Asp 
    210                 215                 220                 


Thr Ile Ser Arg Tyr Lys Glu Gly Lys Pro Val Phe Tyr Tyr Thr Trp 
225                 230                 235                 240 


Thr Pro Tyr Trp Val Ser Asn Glu Leu Lys Pro Gly Lys Asp Val Val 
                245                 250                 255     


Trp Leu Gln Val Pro Phe Ser Ala Leu Pro Gly Asp Lys Asn Ala Asp 
            260                 265                 270         


Thr Lys Leu Pro Asn Gly Ala Asn Tyr Gly Phe Pro Val Ser Thr Met 
        275                 280                 285             


His Ile Val Ala Asn Lys Ala Trp Ala Glu Lys Asn Pro Ala Ala Ala 
    290                 295                 300                 


Lys Leu Phe Ala Ile Met Gln Leu Pro Val Ala Asp Ile Asn Ala Gln 
305                 310                 315                 320 


Asn Ala Ile Met His Asp Gly Lys Ala Ser Glu Gly Asp Ile Gln Gly 
                325                 330                 335     


His Val Asp Gly Trp Ile Lys Ala His Gln Gln Gln Phe Asp Gly Trp 
            340                 345                 350         


Val Asn Glu Ala Leu Ala Ala Gln Lys Gly Ser Gly Gly Ala Asp Leu 
        355                 360                 365             


Pro Gly Lys Gly Ile Thr Val Asn Pro Val Gln Ser Thr Ile Thr Glu 
    370                 375                 380                 


Glu Thr Phe Gln Thr Leu Leu Val Ser Arg Ala Leu Glu Lys Leu Gly 
385                 390                 395                 400 


Tyr Thr Val Asn Lys Pro Ser Glu Val Asp Tyr Asn Val Gly Tyr Thr 
                405                 410                 415     


Ser Leu Ala Ser Gly Asp Ala Thr Phe Thr Ala Val Asn Trp Thr Pro 
            420                 425                 430         


Leu His Asp Asn Met Tyr Glu Ala Ala Gly Gly Asp Lys Lys Phe Tyr 
        435                 440                 445             


Arg Leu Asn Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    530                 535                 540                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                565                 570                 575     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            580                 585                 590         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
        595                 600                 605             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    610                 615                 620                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
625                 630                 635                 640 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                645                 650                 655     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            660                 665                 670         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        675                 680                 685             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    690                 695                 700                 


His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
705                 710                 715                 720 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                725                 730                 735     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            740                 745                 750         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        755                 760                 765             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    770                 775                 780                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
785                 790                 795                 800 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
                805                 810                 815     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            820                 825                 830         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        835                 840                 845             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    850                 855                 860                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
865                 870                 875                 880 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                885                 890                 895     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            900                 905                 910         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        915                 920                 925             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
    930                 935                 940                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
945                 950                 955                 960 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                965                 970                 975     


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            980                 985                 990         


Leu Cys Gln Ala His Gly Leu Thr  Pro Glu Gln Val Val  Ala Ile Ala 
        995                 1000                 1005             


Ser Asn  Gly Gly Gly Lys Gln  Ala Leu Glu Thr Val  Gln Arg Leu 
    1010                 1015                 1020             


Leu Pro  Val Leu Cys Gln Ala  His Gly Leu Thr Pro  Glu Gln Val 
    1025                 1030                 1035             


Val Ala  Ile Ala Ser Asn Gly  Gly Gly Arg Pro Ala  Leu Glu Ser 
    1040                 1045                 1050             


Ile Val  Ala Gln Leu Ser Arg  Pro Asp Pro Ala Leu  Ala Ala Leu 
    1055                 1060                 1065             


Thr Asn  Asp His Leu Val Ala  Leu Ala Cys Leu Gly  Gly Arg Pro 
    1070                 1075                 1080             


Ala Leu  Asp Ala Val Lys Lys  Gly Leu Pro His Ala  Pro Ala Leu 
    1085                 1090                 1095             


Ile Lys  Arg Thr Asn Arg Arg  Ile Pro Glu Arg Thr  Ser His Arg 
    1100                 1105                 1110             


Val Ala  Asp His Ala Gln Val  Val Arg Val Leu Gly  Phe Phe Gln 
    1115                 1120                 1125             


Cys His  Ser His Pro Ala Gln  Ala Phe Asp Asp Ala  Met Thr Gln 
    1130                 1135                 1140             


Phe Gly  Met Ser Asp Tyr Lys  Asp Asp Asp Asp Lys  
    1145                 1150                 1155 


<210>  7
<211>  1155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
                85                  90                  95      


Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile 
            100                 105                 110         


Ala Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg 
        115                 120                 125             


Asn Ala Leu Thr Gly Ala Pro Leu Val Gln Lys Ala Asp Leu Thr Gly 
    130                 135                 140                 


Cys Asn Pro Gly Trp Gly Cys Glu Gly Ala Ile Asn His Gln Leu Ala 
145                 150                 155                 160 


Ala Tyr Glu Leu Thr Asn Thr Val Thr His Asn Gln Gly Asn Tyr Ala 
                165                 170                 175     


Ala Met Met Ala Asp Thr Ile Ser Arg Tyr Lys Glu Gly Lys Pro Val 
            180                 185                 190         


Phe Tyr Tyr Thr Trp Thr Pro Tyr Trp Val Ser Asn Glu Leu Lys Pro 
        195                 200                 205             


Gly Lys Asp Val Val Trp Leu Gln Val Pro Phe Ser Ala Leu Pro Gly 
    210                 215                 220                 


Asp Lys Asn Ala Asp Thr Lys Leu Pro Asn Gly Ala Asn Tyr Gly Phe 
225                 230                 235                 240 


Pro Val Ser Thr Met His Ile Val Ala Asn Lys Ala Trp Ala Glu Lys 
                245                 250                 255     


Asn Pro Ala Ala Ala Lys Leu Phe Ala Ile Met Gln Leu Pro Val Ala 
            260                 265                 270         


Asp Ile Asn Ala Gln Asn Ala Ile Met His Asp Gly Lys Ala Ser Glu 
        275                 280                 285             


Gly Asp Ile Gln Gly His Val Asp Gly Trp Ile Lys Ala His Gln Gln 
    290                 295                 300                 


Gln Phe Asp Gly Trp Val Asn Glu Ala Leu Ala Ala Gln Lys Gly Ser 
305                 310                 315                 320 


Gly Gly Ala Asp Leu Pro Gly Lys Gly Ile Thr Val Asn Pro Val Gln 
                325                 330                 335     


Ser Thr Ile Thr Glu Glu Thr Phe Gln Thr Leu Leu Val Ser Arg Ala 
            340                 345                 350         


Leu Glu Lys Leu Gly Tyr Thr Val Asn Lys Pro Ser Glu Val Asp Tyr 
        355                 360                 365             


Asn Val Gly Tyr Thr Ser Leu Ala Ser Gly Asp Ala Thr Phe Thr Ala 
    370                 375                 380                 


Val Asn Trp Thr Pro Leu His Asp Asn Met Tyr Glu Ala Ala Gly Gly 
385                 390                 395                 400 


Asp Lys Lys Phe Tyr Arg Glu Gly Val Phe Val Asn Gly Ala Ala Gln 
                405                 410                 415     


Gly Tyr Leu Ile Asp Lys Lys Thr Ala Asp Gln Tyr Lys Ile Thr Asn 
            420                 425                 430         


Ile Ala Gln Leu Lys Asp Pro Lys Ile Ala Lys Leu Phe Asp Thr Asn 
        435                 440                 445             


Gly Asp Gly Ile His Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    450                 455                 460                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
465                 470                 475                 480 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                485                 490                 495     


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            500                 505                 510         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        515                 520                 525             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    530                 535                 540                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
545                 550                 555                 560 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                565                 570                 575     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            580                 585                 590         


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
        595                 600                 605             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
    610                 615                 620                 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
625                 630                 635                 640 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
                645                 650                 655     


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly 
            660                 665                 670         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        675                 680                 685             


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    690                 695                 700                 


His Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
705                 710                 715                 720 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                725                 730                 735     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            740                 745                 750         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        755                 760                 765             


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    770                 775                 780                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
785                 790                 795                 800 


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
                805                 810                 815     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            820                 825                 830         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        835                 840                 845             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    850                 855                 860                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
865                 870                 875                 880 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                885                 890                 895     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            900                 905                 910         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        915                 920                 925             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
    930                 935                 940                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
945                 950                 955                 960 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                965                 970                 975     


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            980                 985                 990         


Leu Cys Gln Ala His Gly Leu Thr  Pro Glu Gln Val Val  Ala Ile Ala 
        995                 1000                 1005             


Ser Asn  Gly Gly Gly Lys Gln  Ala Leu Glu Thr Val  Gln Arg Leu 
    1010                 1015                 1020             


Leu Pro  Val Leu Cys Gln Ala  His Gly Leu Thr Pro  Glu Gln Val 
    1025                 1030                 1035             


Val Ala  Ile Ala Ser Asn Gly  Gly Gly Arg Pro Ala  Leu Glu Ser 
    1040                 1045                 1050             


Ile Val  Ala Gln Leu Ser Arg  Pro Asp Pro Ala Leu  Ala Ala Leu 
    1055                 1060                 1065             


Thr Asn  Asp His Leu Val Ala  Leu Ala Cys Leu Gly  Gly Arg Pro 
    1070                 1075                 1080             


Ala Leu  Asp Ala Val Lys Lys  Gly Leu Pro His Ala  Pro Ala Leu 
    1085                 1090                 1095             


Ile Lys  Arg Thr Asn Arg Arg  Ile Pro Glu Arg Thr  Ser His Arg 
    1100                 1105                 1110             


Val Ala  Asp His Ala Gln Val  Val Arg Val Leu Gly  Phe Phe Gln 
    1115                 1120                 1125             


Cys His  Ser His Pro Ala Gln  Ala Phe Asp Asp Ala  Met Thr Gln 
    1130                 1135                 1140             


Phe Gly  Met Ser Asp Tyr Lys  Asp Asp Asp Asp Lys  
    1145                 1150                 1155 


<210>  8
<211>  1153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Pro 
                85                  90                  95      


Val Ser Thr Met His Ile Val Ala Asn Lys Ala Trp Ala Glu Lys Asn 
            100                 105                 110         


Pro Ala Ala Ala Lys Leu Phe Ala Ile Met Gln Leu Pro Val Ala Asp 
        115                 120                 125             


Ile Asn Ala Gln Asn Ala Ile Met His Asp Gly Lys Ala Ser Glu Gly 
    130                 135                 140                 


Asp Ile Gln Gly His Val Asp Gly Trp Ile Lys Ala His Gln Gln Gln 
145                 150                 155                 160 


Phe Asp Gly Trp Val Asn Glu Ala Leu Ala Ala Gln Lys Gly Ser Gly 
                165                 170                 175     


Gly Ala Asp Leu Pro Gly Lys Gly Ile Thr Val Asn Pro Val Gln Ser 
            180                 185                 190         


Thr Ile Thr Glu Glu Thr Phe Gln Thr Leu Leu Val Ser Arg Ala Leu 
        195                 200                 205             


Glu Lys Leu Gly Tyr Thr Val Asn Lys Pro Ser Glu Val Asp Tyr Asn 
    210                 215                 220                 


Val Gly Tyr Thr Ser Leu Ala Ser Gly Asp Ala Thr Phe Thr Ala Val 
225                 230                 235                 240 


Asn Trp Thr Pro Leu His Asp Asn Met Tyr Glu Ala Ala Gly Gly Asp 
                245                 250                 255     


Lys Lys Phe Tyr Arg Glu Gly Val Phe Val Asn Gly Ala Ala Gln Gly 
            260                 265                 270         


Tyr Leu Ile Asp Lys Lys Thr Ala Asp Gln Tyr Lys Ile Thr Asn Ile 
        275                 280                 285             


Ala Gln Leu Lys Asp Pro Lys Ile Ala Lys Leu Phe Asp Thr Asn Gly 
    290                 295                 300                 


Asp Gly Lys Ala Asp Leu Thr Gly Cys Asn Pro Gly Trp Gly Cys Glu 
305                 310                 315                 320 


Gly Ala Ile Asn His Gln Leu Ala Ala Tyr Glu Leu Thr Asn Thr Val 
                325                 330                 335     


Thr His Asn Gln Gly Asn Tyr Ala Ala Met Met Ala Asp Thr Ile Ser 
            340                 345                 350         


Arg Tyr Lys Glu Gly Lys Pro Val Phe Tyr Tyr Thr Trp Thr Pro Tyr 
        355                 360                 365             


Trp Val Ser Asn Glu Leu Lys Pro Gly Lys Asp Val Val Trp Leu Gln 
    370                 375                 380                 


Val Pro Phe Ser Ala Leu Pro Gly Asp Lys Asn Ala Asp Thr Lys Leu 
385                 390                 395                 400 


Pro Asn Gly Ala Asn Tyr Gly Phe His Arg Glu Leu Arg Gly Pro Pro 
                405                 410                 415     


Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly 
            420                 425                 430         


Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly 
        435                 440                 445             


Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    450                 455                 460                 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
465                 470                 475                 480 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                485                 490                 495     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            500                 505                 510         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        515                 520                 525             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    530                 535                 540                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
545                 550                 555                 560 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
                565                 570                 575     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            580                 585                 590         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        595                 600                 605             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    610                 615                 620                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
625                 630                 635                 640 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                645                 650                 655     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            660                 665                 670         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        675                 680                 685             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly 
    690                 695                 700                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
705                 710                 715                 720 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                725                 730                 735     


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            740                 745                 750         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        755                 760                 765             


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    770                 775                 780                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
785                 790                 795                 800 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                805                 810                 815     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            820                 825                 830         


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
        835                 840                 845             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    850                 855                 860                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
865                 870                 875                 880 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                885                 890                 895     


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
            900                 905                 910         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        915                 920                 925             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
    930                 935                 940                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
945                 950                 955                 960 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                965                 970                 975     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            980                 985                 990         


Gln Ala His Gly Leu Thr Pro Glu  Gln Val Val Ala Ile  Ala Ser Asn 
        995                 1000                 1005             


Gly Gly  Gly Lys Gln Ala Leu  Glu Thr Val Gln Arg  Leu Leu Pro 
    1010                 1015                 1020             


Val Leu  Cys Gln Ala His Gly  Leu Thr Pro Glu Gln  Val Val Ala 
    1025                 1030                 1035             


Ile Ala  Ser Asn Gly Gly Gly  Arg Pro Ala Leu Glu  Ser Ile Val 
    1040                 1045                 1050             


Ala Gln  Leu Ser Arg Pro Asp  Pro Ala Leu Ala Ala  Leu Thr Asn 
    1055                 1060                 1065             


Asp His  Leu Val Ala Leu Ala  Cys Leu Gly Gly Arg  Pro Ala Leu 
    1070                 1075                 1080             


Asp Ala  Val Lys Lys Gly Leu  Pro His Ala Pro Ala  Leu Ile Lys 
    1085                 1090                 1095             


Arg Thr  Asn Arg Arg Ile Pro  Glu Arg Thr Ser His  Arg Val Ala 
    1100                 1105                 1110             


Asp His  Ala Gln Val Val Arg  Val Leu Gly Phe Phe  Gln Cys His 
    1115                 1120                 1125             


Ser His  Pro Ala Gln Ala Phe  Asp Asp Ala Met Thr  Gln Phe Gly 
    1130                 1135                 1140             


Met Ser  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1145                 1150             


<210>  9
<211>  1153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Met Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys 
1               5                   10                  15      


Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu 
            20                  25                  30          


Val Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His 
        35                  40                  45              


Pro Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala 
    50                  55                  60                  


Ala Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln 
65                  70                  75                  80  


Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu 
                85                  90                  95      


Leu Arg Gly Thr Gly Cys Asn Pro Gly Trp Gly Cys Glu Gly Ala Ile 
            100                 105                 110         


Asn His Gln Leu Ala Ala Tyr Glu Leu Thr Asn Thr Val Thr His Asn 
        115                 120                 125             


Gln Gly Asn Tyr Ala Ala Met Met Ala Asp Thr Ile Ser Arg Tyr Lys 
    130                 135                 140                 


Glu Gly Lys Pro Val Phe Tyr Tyr Thr Trp Thr Pro Tyr Trp Val Ser 
145                 150                 155                 160 


Asn Glu Leu Lys Pro Gly Lys Asp Val Val Trp Leu Gln Val Pro Phe 
                165                 170                 175     


Ser Ala Leu Pro Gly Asp Lys Asn Ala Asp Thr Lys Leu Pro Asn Gly 
            180                 185                 190         


Ala Asn Tyr Gly Phe Pro Val Ser Thr Met His Ile Val Ala Asn Lys 
        195                 200                 205             


Ala Trp Ala Glu Lys Asn Pro Ala Ala Ala Lys Leu Phe Ala Ile Met 
    210                 215                 220                 


Gln Leu Pro Val Ala Asp Ile Asn Ala Gln Asn Ala Ile Met His Asp 
225                 230                 235                 240 


Gly Lys Ala Ser Glu Gly Asp Ile Gln Gly His Val Asp Gly Trp Ile 
                245                 250                 255     


Lys Ala His Gln Gln Gln Phe Asp Gly Trp Val Asn Glu Ala Leu Ala 
            260                 265                 270         


Ala Gln Lys Gly Ser Gly Gly Ala Asp Leu Pro Gly Lys Gly Ile Thr 
        275                 280                 285             


Val Asn Pro Val Gln Ser Thr Ile Thr Glu Glu Thr Phe Gln Thr Leu 
    290                 295                 300                 


Leu Val Ser Arg Ala Leu Glu Lys Leu Gly Tyr Thr Val Asn Lys Pro 
305                 310                 315                 320 


Ser Glu Val Asp Tyr Asn Val Gly Tyr Thr Ser Leu Ala Ser Gly Asp 
                325                 330                 335     


Ala Thr Phe Thr Ala Val Asn Trp Thr Pro Leu His Asp Asn Met Tyr 
            340                 345                 350         


Glu Ala Ala Gly Gly Asp Lys Lys Phe Tyr Arg Glu Gly Val Phe Val 
        355                 360                 365             


Asn Gly Ala Ala Gln Gly Tyr Leu Ile Asp Lys Lys Thr Ala Asp Gln 
    370                 375                 380                 


Tyr Lys Ile Thr Asn Ile Ala Gln Leu Lys Asp Pro Lys Ile Ala Lys 
385                 390                 395                 400 


Leu Phe Asp Thr Asn Gly Asp Gly Lys Ala Asp Leu Arg Pro Pro Pro 
                405                 410                 415     


Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly 
            420                 425                 430         


Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly 
        435                 440                 445             


Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
    450                 455                 460                 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
465                 470                 475                 480 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                485                 490                 495     


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            500                 505                 510         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
        515                 520                 525             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    530                 535                 540                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
545                 550                 555                 560 


Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val 
                565                 570                 575     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            580                 585                 590         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        595                 600                 605             


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    610                 615                 620                 


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
625                 630                 635                 640 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                645                 650                 655     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            660                 665                 670         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        675                 680                 685             


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn His Gly 
    690                 695                 700                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
705                 710                 715                 720 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
                725                 730                 735     


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            740                 745                 750         


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
        755                 760                 765             


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    770                 775                 780                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
785                 790                 795                 800 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                805                 810                 815     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            820                 825                 830         


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
        835                 840                 845             


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    850                 855                 860                 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
865                 870                 875                 880 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                885                 890                 895     


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
            900                 905                 910         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        915                 920                 925             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
    930                 935                 940                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
945                 950                 955                 960 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
                965                 970                 975     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            980                 985                 990         


Gln Ala His Gly Leu Thr Pro Glu  Gln Val Val Ala Ile  Ala Ser Asn 
        995                 1000                 1005             


Gly Gly  Gly Lys Gln Ala Leu  Glu Thr Val Gln Arg  Leu Leu Pro 
    1010                 1015                 1020             


Val Leu  Cys Gln Ala His Gly  Leu Thr Pro Glu Gln  Val Val Ala 
    1025                 1030                 1035             


Ile Ala  Ser Asn Gly Gly Gly  Arg Pro Ala Leu Glu  Ser Ile Val 
    1040                 1045                 1050             


Ala Gln  Leu Ser Arg Pro Asp  Pro Ala Leu Ala Ala  Leu Thr Asn 
    1055                 1060                 1065             


Asp His  Leu Val Ala Leu Ala  Cys Leu Gly Gly Arg  Pro Ala Leu 
    1070                 1075                 1080             


Asp Ala  Val Lys Lys Gly Leu  Pro His Ala Pro Ala  Leu Ile Lys 
    1085                 1090                 1095             


Arg Thr  Asn Arg Arg Ile Pro  Glu Arg Thr Ser His  Arg Val Ala 
    1100                 1105                 1110             


Asp His  Ala Gln Val Val Arg  Val Leu Gly Phe Phe  Gln Cys His 
    1115                 1120                 1125             


Ser His  Pro Ala Gln Ala Phe  Asp Asp Ala Met Thr  Gln Phe Gly 
    1130                 1135                 1140             


Met Ser  Asp Tyr Lys Asp Asp  Asp Asp Lys 
    1145                 1150             


<210>  10
<211>  1161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Met His His His His His His Val Asp Leu Arg Thr Leu Gly Tyr Ser 
1               5                   10                  15      


Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala 
            20                  25                  30          


Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile 
        35                  40                  45              


Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Lys 
    50                  55                  60                  


Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala Ile 
65                  70                  75                  80  


Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu 
                85                  90                  95      


Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr 
            100                 105                 110         


Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val Glu 
        115                 120                 125             


Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Val Gln 
    130                 135                 140                 


Lys Ala Asp Leu Thr Gly Cys Asn Pro Gly Trp Gly Cys Glu Gly Ala 
145                 150                 155                 160 


Ile Asn His Gln Leu Ala Ala Tyr Glu Leu Thr Asn Thr Val Thr His 
                165                 170                 175     


Asn Gln Gly Asn Tyr Ala Ala Met Met Ala Asp Thr Ile Ser Arg Tyr 
            180                 185                 190         


Lys Glu Gly Lys Pro Val Phe Tyr Tyr Thr Trp Thr Pro Tyr Trp Val 
        195                 200                 205             


Ser Asn Glu Leu Lys Pro Gly Lys Asp Val Val Trp Leu Gln Val Pro 
    210                 215                 220                 


Phe Ser Ala Leu Pro Gly Asp Lys Asn Ala Asp Thr Lys Leu Pro Asn 
225                 230                 235                 240 


Gly Ala Asn Tyr Gly Phe Pro Val Ser Thr Met His Ile Val Ala Asn 
                245                 250                 255     


Lys Ala Trp Ala Glu Lys Asn Pro Ala Ala Ala Lys Leu Phe Ala Ile 
            260                 265                 270         


Met Gln Leu Pro Val Ala Asp Ile Asn Ala Gln Asn Ala Ile Met His 
        275                 280                 285             


Asp Gly Lys Ala Ser Glu Gly Asp Ile Gln Gly His Val Asp Gly Trp 
    290                 295                 300                 


Ile Lys Ala His Gln Gln Gln Phe Asp Gly Trp Val Asn Glu Ala Leu 
305                 310                 315                 320 


Ala Ala Gln Lys Gly Ser Gly Gly Ala Asp Leu Pro Gly Lys Gly Ile 
                325                 330                 335     


Thr Val Asn Pro Val Gln Ser Thr Ile Thr Glu Glu Thr Phe Gln Thr 
            340                 345                 350         


Leu Leu Val Ser Arg Ala Leu Glu Lys Leu Gly Tyr Thr Val Asn Lys 
        355                 360                 365             


Pro Ser Glu Val Asp Tyr Asn Val Gly Tyr Thr Ser Leu Ala Ser Gly 
    370                 375                 380                 


Asp Ala Thr Phe Thr Ala Val Asn Trp Thr Pro Leu His Asp Asn Met 
385                 390                 395                 400 


Tyr Glu Ala Ala Gly Gly Asp Lys Lys Phe Tyr Arg Glu Gly Val Phe 
                405                 410                 415     


Val Asn Gly Ala Ala Gln Gly Tyr Leu Ile Asp Lys Lys Thr Ala Asp 
            420                 425                 430         


Gln Tyr Lys Ile Thr Asn Ile Ala Gln Leu Lys Asp Pro Lys Ile Ala 
        435                 440                 445             


Lys Leu Phe Asp Thr Asn Gly Asp Gly Ile His Asn Leu Thr Pro Glu 
    450                 455                 460                 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
465                 470                 475                 480 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                485                 490                 495     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
            500                 505                 510         


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        515                 520                 525             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
    530                 535                 540                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
545                 550                 555                 560 


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
                565                 570                 575     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            580                 585                 590         


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
        595                 600                 605             


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
    610                 615                 620                 


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
625                 630                 635                 640 


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
                645                 650                 655     


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
            660                 665                 670         


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
        675                 680                 685             


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
    690                 695                 700                 


Val Ala Ile Ala Ser Asn His Gly Gly Lys Gln Ala Leu Glu Thr Val 
705                 710                 715                 720 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
                725                 730                 735     


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
            740                 745                 750         


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
        755                 760                 765             


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
    770                 775                 780                 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
785                 790                 795                 800 


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                805                 810                 815     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            820                 825                 830         


His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
        835                 840                 845             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    850                 855                 860                 


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
865                 870                 875                 880 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                885                 890                 895     


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            900                 905                 910         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        915                 920                 925             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    930                 935                 940                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
945                 950                 955                 960 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                965                 970                 975     


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
            980                 985                 990         


Gln Arg Leu Leu Pro Val Leu Cys  Gln Ala His Gly Leu  Thr Pro Glu 
        995                 1000                 1005             


Gln Val  Val Ala Ile Ala Ser  Asn Gly Gly Gly Lys  Gln Ala Leu 
    1010                 1015                 1020             


Glu Thr  Val Gln Arg Leu Leu  Pro Val Leu Cys Gln  Ala His Gly 
    1025                 1030                 1035             


Leu Thr  Pro Glu Gln Val Val  Ala Ile Ala Ser Asn  Gly Gly Gly 
    1040                 1045                 1050             


Arg Pro  Ala Leu Glu Ser Ile  Val Ala Gln Leu Ser  Arg Pro Asp 
    1055                 1060                 1065             


Pro Ala  Leu Ala Ala Leu Thr  Asn Asp His Leu Val  Ala Leu Ala 
    1070                 1075                 1080             


Cys Leu  Gly Gly Arg Pro Ala  Leu Asp Ala Val Lys  Lys Gly Leu 
    1085                 1090                 1095             


Pro His  Ala Pro Ala Leu Ile  Lys Arg Thr Asn Arg  Arg Ile Pro 
    1100                 1105                 1110             


Glu Arg  Thr Ser His Arg Val  Ala Asp His Ala Gln  Val Val Arg 
    1115                 1120                 1125             


Val Leu  Gly Phe Phe Gln Cys  His Ser His Pro Ala  Gln Ala Phe 
    1130                 1135                 1140             


Asp Asp  Ala Met Thr Gln Phe  Gly Met Ser Asp Tyr  Lys Asp Asp 
    1145                 1150                 1155             


Asp Asp  Lys 
    1160     


