                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior
       University
 
<120>  CILIARY NEUROTROPHIC FACTOR RECEPTOR LIGANDS AND METHODS OF USING
        THE SAME

<130>  STAN-1369WO

<150>  US 62/515,746
<151>  2017-06-06

<150>  US 62/443,554
<151>  2017-01-06

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  2
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Phe Thr Glu His Ser Pro Leu Thr Pro His Arg Arg Asp Leu 
1               5                   10                  15      


Cys Ser Arg Ser Ile Trp Leu Ala Arg Lys Ile Arg Ser Asp Leu Thr 
            20                  25                  30          


Ala Leu Thr Glu Ser Tyr Val Lys His Gln Gly Leu Asn Lys Asn Ile 
        35                  40                  45              


Asn Leu Asp Ser Ala Asp Gly Met Pro Val Ala Ser Thr Asp Gln Trp 
    50                  55                  60                  


Ser Glu Leu Thr Glu Ala Glu Arg Leu Gln Glu Asn Leu Gln Ala Tyr 
65                  70                  75                  80  


Arg Thr Phe His Val Leu Leu Ala Arg Leu Leu Glu Asp Gln Gln Val 
                85                  90                  95      


His Phe Thr Pro Thr Glu Gly Asp Phe His Gln Ala Ile His Thr Leu 
            100                 105                 110         


Leu Leu Gln Val Ala Ala Phe Ala Tyr Gln Ile Glu Glu Leu Met Ile 
        115                 120                 125             


Leu Leu Glu Tyr Lys Ile Pro Arg Asn Glu Ala Asp Gly Met Pro Ile 
    130                 135                 140                 


Asn Val Gly Asp Gly Gly Leu Phe Glu Lys Lys Leu Trp Gly Leu Lys 
145                 150                 155                 160 


Val Leu Gln Glu Leu Ser Gln Trp Thr Val Arg Ser Ile His Asp Leu 
                165                 170                 175     


Arg Phe Ile Ser Ser His Gln Thr Gly Ile Pro Ala Arg Gly Ser His 
            180                 185                 190         


Tyr Ile Ala Asn Asn Lys Lys Met 
        195                 200 


<210>  3
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Leu Arg Ala Gly Asp Ser Trp Gly Met Leu Ala Cys Leu Cys 
1               5                   10                  15      


Thr Val Leu Trp His Leu Pro Ala Val Pro Ala Leu Asn Arg Thr Gly 
            20                  25                  30          


Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr Tyr Asp Leu Thr Arg 
        35                  40                  45              


Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly Thr Tyr Leu Asn Tyr 
    50                  55                  60                  


Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn Pro Pro Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu Glu Val Trp Arg Ser 
                85                  90                  95      


Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr Glu Ala Tyr Ser His 
            100                 105                 110         


Leu Leu Cys Tyr Leu Arg Gly Leu Asn Arg Gln Ala Ala Thr Ala Glu 
        115                 120                 125             


Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser Leu Gln Gly Leu Leu 
    130                 135                 140                 


Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly Tyr Pro Leu Pro Gln 
145                 150                 155                 160 


Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro Gly Pro Ala His Ser 
                165                 170                 175     


Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu Leu Lys Glu Leu Gln 
            180                 185                 190         


Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn Arg Leu Lys Lys Lys 
        195                 200                 205             


Met Gln Pro Pro Ala Ala Ala Val Thr Leu His Leu Gly Ala His Gly 
    210                 215                 220                 


Phe 
225 


<210>  4
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Tyr Cys Leu Leu Ala Thr Pro Leu Cys Leu Leu Ser Leu Leu Leu 
1               5                   10                  15      


Pro Pro Leu Ser Pro Ala Ala Pro Ile Ser Pro Ser Glu Pro Ile Gly 
            20                  25                  30          


Gln Ala Tyr Ser Leu Ala Leu Tyr Met Gln Lys Asn Thr Ser Ala Leu 
        35                  40                  45              


Leu Gln Thr Tyr Leu Gln His Gln Gly Ser Pro Phe Ser Asp Pro Gly 
    50                  55                  60                  


Phe Ser Ala Pro Glu Leu Gln Leu Ser Thr Leu Pro Ser Ala Ala Val 
65                  70                  75                  80  


Ser Phe Lys Thr Trp His Ala Met Glu Asp Ala Glu Arg Leu Ser Arg 
                85                  90                  95      


Ala Gln Gly Ala Phe Leu Ala Leu Thr Gln His Leu Gln Leu Val Gly 
            100                 105                 110         


Asp Asp Gln Ser Tyr Leu Asn Pro Gly Ser Pro Ile Leu Leu Ala Gln 
        115                 120                 125             


Leu Gly Ala Ala Arg Leu Arg Ala Gln Gly Leu Leu Gly Asn Met Ala 
    130                 135                 140                 


Ala Ile Met Thr Ala Leu Gly Leu Pro Ile Pro Pro Glu Glu Asp Thr 
145                 150                 155                 160 


Leu Gly Phe Val Pro Phe Gly Ala Ser Ala Phe Glu Arg Lys Cys Arg 
                165                 170                 175     


Gly Tyr Ile Val Thr Arg Glu Tyr Gly His Trp Thr Asp Arg Ala Val 
            180                 185                 190         


Arg Asp Leu Ala Leu Leu Lys Ala Lys Tyr Ser Ala 
        195                 200                 


<210>  5
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  5

Leu Asn Arg Thr Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr 
1               5                   10                  15      


Tyr Asp Leu Thr Arg Tyr Leu Glu His Gln Leu Arg Ser Leu Ala Gly 
            20                  25                  30          


Thr Tyr Leu Asn Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn 
        35                  40                  45              


Pro Pro Arg Leu Gly Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu 
    50                  55                  60                  


Glu Val Trp Arg Ser Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr 
65                  70                  75                  80  


Glu Ala Tyr Ser His Phe Leu Cys Tyr Leu Arg Gly Leu Asn Arg Arg 
                85                  90                  95      


Ala Ala Thr Ala Glu Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly 
        115                 120                 125             


Tyr Pro Leu Pro Gln Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro 
    130                 135                 140                 


Gly Pro Ala Arg Ser Asp Phe Leu Gln Lys Met Asp Asp Phe Trp Leu 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Thr Trp Leu Trp Arg Ser Ala Lys Asp Phe Asn 
                165                 170                 175     


Arg Leu Lys Lys Lys Met Gln Pro Pro Ala Ala Ala Val Thr Leu His 
            180                 185                 190         


Leu Gly Ala His Gly Phe 
        195             


<210>  6
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  6

Leu Asn Arg Thr Gly Asp Pro Gly Pro Gly Pro Ser Ile Gln Lys Thr 
1               5                   10                  15      


Tyr Asp Leu Thr Arg Cys Leu Glu His Gln Leu Arg Ser Leu Ala Gly 
            20                  25                  30          


Thr Tyr Leu Asn Tyr Leu Gly Pro Pro Phe Asn Glu Pro Asp Phe Asn 
        35                  40                  45              


Pro Pro Arg Leu Gly Ala Glu Thr Leu Pro Arg Ala Thr Val Asp Leu 
    50                  55                  60                  


Glu Val Trp Arg Ser Leu Asn Asp Lys Leu Arg Leu Thr Gln Asn Tyr 
65                  70                  75                  80  


Glu Ala Tyr Ser His Phe Leu Cys Tyr Leu Arg Gly Leu Asn Arg Arg 
                85                  90                  95      


Ala Ala Thr Ala Glu Leu Arg Arg Ser Leu Ala His Phe Cys Thr Ser 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Ser Ile Ala Gly Val Met Ala Ala Leu Gly 
        115                 120                 125             


Tyr Pro Leu Pro Gln Pro Leu Pro Gly Thr Glu Pro Thr Trp Thr Pro 
    130                 135                 140                 


Gly Pro Ala Arg Ser Asp Ala Leu Gln Ala Met Asp Asp Phe Trp Leu 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Thr Trp Leu Leu Arg Ser Ala Lys Asp Phe Asn 
                165                 170                 175     


Arg Leu Lys Arg Lys Met Gln Pro Pro Ala Ala Ala Val Thr Leu His 
            180                 185                 190         


Leu Gly Ala His Gly Phe 
        195             


<210>  7
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


