                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
       The Walter and Eliza Hall Institute of Medical Research
       INSERM (Insitut National De La Santé Et De La Recherche 
       Médicale)
       Universitätsmedizin Göttingen
 
<120>  MUTANT SMCHD1 FOR THERAPY

<130>  9869Sg4891

<150>  Singapore patent application No. 10201700129W
<151>  2017-01-06

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr 
1               5                   10                  15      


Glu Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp 
            20                  25                  30          


Arg Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly 
        35                  40                  45              


Glu Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu 
    50                  55                  60                  


Gly Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys 
65                  70                  75                  80  


Glu Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr 
                85                  90                  95      


Leu Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys 
            100                 105                 110         


Glu Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly 
        115                 120                 125             


Met Tyr Glu Tyr Tyr Ala Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala 
    130                 135                 140                 


Leu Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile 
145                 150                 155                 160 


Gly Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly 
                165                 170                 175     


Lys Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys 
            180                 185                 190         


Gln Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln 
        195                 200                 205             


Gly Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val 
    210                 215                 220                 


Pro Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys 
225                 230                 235                 240 


Gln Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro 
                245                 250                 255     


Ala Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe 
            260                 265                 270         


Glu Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg 
        275                 280                 285             


Asn Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Phe Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr 
305                 310                 315                 320 


Ala Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys 
                325                 330                 335     


Asn Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr 
            340                 345                 350         


Tyr Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val 
        355                 360                 365             


Glu Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly 
    370                 375                 380                 


Lys Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln 
385                 390                 395                 400 


Thr Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His 
                405                 410                 415     


Val Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe 
            420                 425                 430         


Leu Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys 
        435                 440                 445             


Leu Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala 
    450                 455                 460                 


Ala Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu 
465                 470                 475                 480 


Ile Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys 
                485                 490                 495     


Lys Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala 
            500                 505                 510         


Leu Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe 
        515                 520                 525             


Met Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg 
    530                 535                 540                 


Ile Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe 
                565                 570                 575     


Thr Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys 
            580                 585                 590         


Gln Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile 
        595                 600                 605             


Tyr Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe 
    610                 615                 620                 


Tyr Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu 
625                 630                 635                 640 


Val Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala 
                645                 650                 655     


Leu Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr 
            660                 665                 670         


Val Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg 
        675                 680                 685             


Leu Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu 
    690                 695                 700                 


Pro Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile 
705                 710                 715                 720 


Glu Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr 
                725                 730                 735     


Ser His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu 
            740                 745                 750         


His Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His 
        755                 760                 765             


Gly Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys 
    770                 775                 780                 


Leu Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn 
785                 790                 795                 800 


Ala Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe 
                805                 810                 815     


Ser Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp 
            820                 825                 830         


Leu Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln 
        835                 840                 845             


Asp Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val 
    850                 855                 860                 


Leu Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly 
865                 870                 875                 880 


Pro Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser 
                885                 890                 895     


Cys Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys 
            900                 905                 910         


Glu Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg 
        915                 920                 925             


Arg Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly 
    930                 935                 940                 


Thr Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile 
945                 950                 955                 960 


Thr Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro 
                965                 970                 975     


Asn Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Leu Thr Gly Ser Ala Ile Gln Val  Gln Asn Ile Lys Lys  Asp Gln Thr 
        995                 1000                 1005             


Leu Lys  Ala Arg Ile Glu Ile  Pro Ser Cys Lys Asp  Val Ala Pro 
    1010                 1015                 1020             


Val Glu  Lys Thr Ile Lys Leu  Leu Pro Ser Ser His  Val Ala Arg 
    1025                 1030                 1035             


Leu Gln  Ile Phe Ser Val Glu  Gly Gln Lys Ala Ile  Gln Ile Lys 
    1040                 1045                 1050             


His Gln  Asp Glu Val Asn Trp  Ile Ala Gly Asp Ile  Met His Asn 
    1055                 1060                 1065             


Leu Ile  Phe Gln Met Tyr Asp  Glu Gly Glu Arg Glu  Ile Asn Ile 
    1070                 1075                 1080             


Thr Ser  Ala Leu Ala Glu Lys  Ile Lys Val Asn Trp  Thr Pro Glu 
    1085                 1090                 1095             


Ile Asn  Lys Glu His Leu Leu  Gln Gly Leu Leu Pro  Asp Val Gln 
    1100                 1105                 1110             


Val Pro  Thr Ser Val Lys Asp  Met Arg Tyr Cys Gln  Val Ser Phe 
    1115                 1120                 1125             


Gln Asp  Asp His Val Ser Leu  Glu Ser Ala Phe Thr  Val Arg Pro 
    1130                 1135                 1140             


Leu Pro  Asp Glu Pro Lys His  Leu Lys Cys Glu Met  Lys Gly Gly 
    1145                 1150                 1155             


Lys Thr  Val Gln Met Gly Gln  Glu Leu Gln Gly Glu  Val Val Ile 
    1160                 1165                 1170             


Ile Ile  Thr Asp Gln Tyr Gly  Asn Gln Ile Gln Ala  Phe Ser Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Ser Leu Ser  Ile Ala Gly Val Gly  Leu Asp Ser 
    1190                 1195                 1200             


Ser Asn  Leu Lys Thr Thr Phe  Gln Glu Asn Thr Gln  Ser Ile Ser 
    1205                 1210                 1215             


Val Arg  Gly Ile Lys Phe Ile  Pro Gly Pro Pro Gly  Asn Lys Asp 
    1220                 1225                 1230             


Leu Cys  Phe Thr Trp Arg Glu  Phe Ser Asp Phe Ile  Arg Val Gln 
    1235                 1240                 1245             


Leu Ile  Ser Gly Pro Pro Ala  Lys Leu Leu Leu Ile  Asp Trp Pro 
    1250                 1255                 1260             


Glu Leu  Lys Glu Ser Ile Pro  Val Ile Asn Gly Arg  Asp Leu Gln 
    1265                 1270                 1275             


Asn Pro  Ile Ile Val Gln Leu  Cys Asp Gln Trp Asp  Asn Pro Ala 
    1280                 1285                 1290             


Pro Val  Gln His Val Lys Ile  Ser Leu Thr Lys Ala  Ser Asn Leu 
    1295                 1300                 1305             


Lys Leu  Met Pro Ser Asn Gln  Gln His Lys Thr Asp  Glu Lys Gly 
    1310                 1315                 1320             


Arg Ala  Asn Leu Gly Val Phe  Ser Val Phe Ala Pro  Arg Gly Glu 
    1325                 1330                 1335             


His Thr  Leu Gln Val Lys Ala  Ile Tyr Asn Lys Ser  Ile Ile Glu 
    1340                 1345                 1350             


Gly Pro  Ile Ile Lys Leu Met  Ile Leu Pro Asp Pro  Glu Lys Pro 
    1355                 1360                 1365             


Val Arg  Leu Asn Val Lys Tyr  Asp Lys Asp Ala Ser  Phe Leu Ala 
    1370                 1375                 1380             


Gly Gly  Leu Phe Thr Asp Phe  Met Ile Ser Val Ile  Ser Glu Asp 
    1385                 1390                 1395             


Asp Ser  Ile Ile Lys Asn Ile  Asn Pro Ala Arg Ile  Ser Met Lys 
    1400                 1405                 1410             


Met Trp  Lys Leu Ser Thr Ser  Gly Asn Arg Pro Pro  Ala Asn Ala 
    1415                 1420                 1425             


Glu Thr  Phe Ser Cys Asn Lys  Ile Lys Asp Asn Asp  Lys Glu Asp 
    1430                 1435                 1440             


Gly Cys  Phe Tyr Phe Arg Asp  Lys Val Ile Pro Asn  Lys Val Gly 
    1445                 1450                 1455             


Thr Tyr  Cys Ile Gln Phe Gly  Phe Met Met Asp Lys  Thr Asn Ile 
    1460                 1465                 1470             


Leu Asn  Ser Glu Gln Val Ile  Val Glu Val Leu Pro  Asn Gln Pro 
    1475                 1480                 1485             


Val Lys  Leu Val Pro Lys Ile  Lys Pro Pro Thr Pro  Ala Val Ser 
    1490                 1495                 1500             


Asn Val  Arg Ser Val Ala Ser  Arg Thr Leu Val Arg  Asp Leu His 
    1505                 1510                 1515             


Leu Ser  Ile Thr Asp Asp Tyr  Asp Asn His Thr Gly  Ile Asp Leu 
    1520                 1525                 1530             


Val Gly  Thr Ile Ile Ala Thr  Ile Lys Gly Ser Asn  Glu Glu Asp 
    1535                 1540                 1545             


Thr Asp  Thr Pro Leu Phe Ile  Gly Lys Val Arg Thr  Leu Glu Phe 
    1550                 1555                 1560             


Pro Phe  Val Asn Gly Ser Ala  Glu Ile Met Ser Leu  Val Leu Ala 
    1565                 1570                 1575             


Glu Ser  Ser Pro Gly Arg Asp  Ser Thr Glu Tyr Phe  Ile Val Phe 
    1580                 1585                 1590             


Glu Pro  Arg Leu Pro Leu Leu  Ser Arg Thr Leu Glu  Pro Tyr Ile 
    1595                 1600                 1605             


Leu Pro  Phe Met Phe Tyr Asn  Asp Val Lys Lys Gln  Gln Gln Met 
    1610                 1615                 1620             


Ala Ala  Leu Thr Lys Glu Lys  Asp Gln Leu Ser Gln  Ser Ile Val 
    1625                 1630                 1635             


Met Tyr  Lys Ser Leu Phe Glu  Ala Ser Gln Gln Leu  Leu Asn Glu 
    1640                 1645                 1650             


Met Lys  Cys Gln Val Glu Glu  Ala Arg Leu Lys Glu  Ala Gln Leu 
    1655                 1660                 1665             


Arg Asn  Glu Leu Lys Ile His  Asn Ile Asp Ile Pro  Thr Thr Gln 
    1670                 1675                 1680             


Gln Val  Pro His Ile Glu Ala  Leu Leu Lys Arg Lys  Leu Ser Glu 
    1685                 1690                 1695             


Gln Glu  Glu Leu Lys Lys Lys  Pro Arg Arg Ser Cys  Thr Leu Pro 
    1700                 1705                 1710             


Asn Tyr  Thr Lys Gly Ser Gly  Asp Val Leu Gly Lys  Ile Ala His 
    1715                 1720                 1725             


Leu Ala  Gln Ile Glu Asp Asp  Arg Ala Ala Met Val  Ile Ser Trp 
    1730                 1735                 1740             


His Leu  Ala Ser Asp Met Asp  Cys Val Val Thr Leu  Thr Thr Asp 
    1745                 1750                 1755             


Ala Ala  Arg Arg Ile Tyr Asp  Glu Thr Gln Gly Arg  Gln Gln Val 
    1760                 1765                 1770             


Leu Pro  Leu Asp Ser Ile Tyr  Lys Lys Thr Leu Pro  Asp Trp Lys 
    1775                 1780                 1785             


Arg Ser  Leu Pro His Phe Arg  Asn Gly Lys Leu Tyr  Phe Lys Pro 
    1790                 1795                 1800             


Ile Gly  Asp Pro Val Phe Ala  Arg Asp Leu Leu Thr  Phe Pro Asp 
    1805                 1810                 1815             


Asn Val  Glu His Cys Glu Thr  Val Phe Gly Met Leu  Leu Gly Asp 
    1820                 1825                 1830             


Thr Ile  Ile Leu Asp Asn Leu  Asp Ala Ala Asn His  Tyr Arg Lys 
    1835                 1840                 1845             


Glu Val  Val Lys Ile Thr His  Cys Pro Thr Leu Leu  Thr Arg Asp 
    1850                 1855                 1860             


Gly Asp  Arg Ile Arg Ser Asn  Gly Lys Phe Gly Gly  Leu Gln Asn 
    1865                 1870                 1875             


Lys Ala  Pro Pro Met Asp Lys  Leu Arg Gly Met Val  Phe Gly Ala 
    1880                 1885                 1890             


Pro Val  Pro Lys Gln Cys Leu  Ile Leu Gly Glu Gln  Ile Asp Leu 
    1895                 1900                 1905             


Leu Gln  Gln Tyr Arg Ser Ala  Val Cys Lys Leu Asp  Ser Val Asn 
    1910                 1915                 1920             


Lys Asp  Leu Asn Ser Gln Leu  Glu Tyr Leu Arg Thr  Pro Asp Met 
    1925                 1930                 1935             


Arg Lys  Lys Lys Gln Glu Leu  Asp Glu His Glu Lys  Asn Leu Lys 
    1940                 1945                 1950             


Leu Ile  Glu Glu Lys Leu Gly  Met Thr Pro Ile Arg  Lys Cys Asn 
    1955                 1960                 1965             


Asp Ser  Leu Arg His Ser Pro  Lys Val Glu Thr Thr  Asp Cys Pro 
    1970                 1975                 1980             


Val Pro  Pro Lys Arg Met Arg  Arg Glu Ala Thr Arg  Gln Asn Arg 
    1985                 1990                 1995             


Ile Ile  Thr Lys Thr Asp Val  
    2000                 2005 


<210>  2
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr 
1               5                   10                  15      


Glu Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp 
            20                  25                  30          


Arg Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly 
        35                  40                  45              


Glu Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu 
    50                  55                  60                  


Gly Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys 
65                  70                  75                  80  


Glu Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr 
                85                  90                  95      


Leu Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys 
            100                 105                 110         


Glu Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly 
        115                 120                 125             


Met Tyr Glu Tyr Tyr Ser Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala 
    130                 135                 140                 


Leu Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile 
145                 150                 155                 160 


Gly Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly 
                165                 170                 175     


Lys Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys 
            180                 185                 190         


Gln Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln 
        195                 200                 205             


Gly Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val 
    210                 215                 220                 


Pro Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys 
225                 230                 235                 240 


Gln Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro 
                245                 250                 255     


Ala Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe 
            260                 265                 270         


Glu Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg 
        275                 280                 285             


Asn Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Phe Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr 
305                 310                 315                 320 


Ala Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys 
                325                 330                 335     


Asn Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr 
            340                 345                 350         


Tyr Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val 
        355                 360                 365             


Glu Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly 
    370                 375                 380                 


Lys Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln 
385                 390                 395                 400 


Thr Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His 
                405                 410                 415     


Val Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe 
            420                 425                 430         


Leu Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys 
        435                 440                 445             


Leu Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala 
    450                 455                 460                 


Ala Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu 
465                 470                 475                 480 


Ile Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys 
                485                 490                 495     


Lys Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala 
            500                 505                 510         


Leu Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe 
        515                 520                 525             


Met Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg 
    530                 535                 540                 


Ile Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe 
                565                 570                 575     


Thr Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys 
            580                 585                 590         


Gln Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile 
        595                 600                 605             


Tyr Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe 
    610                 615                 620                 


Tyr Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu 
625                 630                 635                 640 


Val Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala 
                645                 650                 655     


Leu Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr 
            660                 665                 670         


Val Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg 
        675                 680                 685             


Leu Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu 
    690                 695                 700                 


Pro Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile 
705                 710                 715                 720 


Glu Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr 
                725                 730                 735     


Ser His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu 
            740                 745                 750         


His Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His 
        755                 760                 765             


Gly Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys 
    770                 775                 780                 


Leu Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn 
785                 790                 795                 800 


Ala Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe 
                805                 810                 815     


Ser Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp 
            820                 825                 830         


Leu Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln 
        835                 840                 845             


Asp Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val 
    850                 855                 860                 


Leu Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly 
865                 870                 875                 880 


Pro Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser 
                885                 890                 895     


Cys Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys 
            900                 905                 910         


Glu Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg 
        915                 920                 925             


Arg Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly 
    930                 935                 940                 


Thr Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile 
945                 950                 955                 960 


Thr Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro 
                965                 970                 975     


Asn Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Leu Thr Gly Ser Ala Ile Gln Val  Gln Asn Ile Lys Lys  Asp Gln Thr 
        995                 1000                 1005             


Leu Lys  Ala Arg Ile Glu Ile  Pro Ser Cys Lys Asp  Val Ala Pro 
    1010                 1015                 1020             


Val Glu  Lys Thr Ile Lys Leu  Leu Pro Ser Ser His  Val Ala Arg 
    1025                 1030                 1035             


Leu Gln  Ile Phe Ser Val Glu  Gly Gln Lys Ala Ile  Gln Ile Lys 
    1040                 1045                 1050             


His Gln  Asp Glu Val Asn Trp  Ile Ala Gly Asp Ile  Met His Asn 
    1055                 1060                 1065             


Leu Ile  Phe Gln Met Tyr Asp  Glu Gly Glu Arg Glu  Ile Asn Ile 
    1070                 1075                 1080             


Thr Ser  Ala Leu Ala Glu Lys  Ile Lys Val Asn Trp  Thr Pro Glu 
    1085                 1090                 1095             


Ile Asn  Lys Glu His Leu Leu  Gln Gly Leu Leu Pro  Asp Val Gln 
    1100                 1105                 1110             


Val Pro  Thr Ser Val Lys Asp  Met Arg Tyr Cys Gln  Val Ser Phe 
    1115                 1120                 1125             


Gln Asp  Asp His Val Ser Leu  Glu Ser Ala Phe Thr  Val Arg Pro 
    1130                 1135                 1140             


Leu Pro  Asp Glu Pro Lys His  Leu Lys Cys Glu Met  Lys Gly Gly 
    1145                 1150                 1155             


Lys Thr  Val Gln Met Gly Gln  Glu Leu Gln Gly Glu  Val Val Ile 
    1160                 1165                 1170             


Ile Ile  Thr Asp Gln Tyr Gly  Asn Gln Ile Gln Ala  Phe Ser Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Ser Leu Ser  Ile Ala Gly Val Gly  Leu Asp Ser 
    1190                 1195                 1200             


Ser Asn  Leu Lys Thr Thr Phe  Gln Glu Asn Thr Gln  Ser Ile Ser 
    1205                 1210                 1215             


Val Arg  Gly Ile Lys Phe Ile  Pro Gly Pro Pro Gly  Asn Lys Asp 
    1220                 1225                 1230             


Leu Cys  Phe Thr Trp Arg Glu  Phe Ser Asp Phe Ile  Arg Val Gln 
    1235                 1240                 1245             


Leu Ile  Ser Gly Pro Pro Ala  Lys Leu Leu Leu Ile  Asp Trp Pro 
    1250                 1255                 1260             


Glu Leu  Lys Glu Ser Ile Pro  Val Ile Asn Gly Arg  Asp Leu Gln 
    1265                 1270                 1275             


Asn Pro  Ile Ile Val Gln Leu  Cys Asp Gln Trp Asp  Asn Pro Ala 
    1280                 1285                 1290             


Pro Val  Gln His Val Lys Ile  Ser Leu Thr Lys Ala  Ser Asn Leu 
    1295                 1300                 1305             


Lys Leu  Met Pro Ser Asn Gln  Gln His Lys Thr Asp  Glu Lys Gly 
    1310                 1315                 1320             


Arg Ala  Asn Leu Gly Val Phe  Ser Val Phe Ala Pro  Arg Gly Glu 
    1325                 1330                 1335             


His Thr  Leu Gln Val Lys Ala  Ile Tyr Asn Lys Ser  Ile Ile Glu 
    1340                 1345                 1350             


Gly Pro  Ile Ile Lys Leu Met  Ile Leu Pro Asp Pro  Glu Lys Pro 
    1355                 1360                 1365             


Val Arg  Leu Asn Val Lys Tyr  Asp Lys Asp Ala Ser  Phe Leu Ala 
    1370                 1375                 1380             


Gly Gly  Leu Phe Thr Asp Phe  Met Ile Ser Val Ile  Ser Glu Asp 
    1385                 1390                 1395             


Asp Ser  Ile Ile Lys Asn Ile  Asn Pro Ala Arg Ile  Ser Met Lys 
    1400                 1405                 1410             


Met Trp  Lys Leu Ser Thr Ser  Gly Asn Arg Pro Pro  Ala Asn Ala 
    1415                 1420                 1425             


Glu Thr  Phe Ser Cys Asn Lys  Ile Lys Asp Asn Asp  Lys Glu Asp 
    1430                 1435                 1440             


Gly Cys  Phe Tyr Phe Arg Asp  Lys Val Ile Pro Asn  Lys Val Gly 
    1445                 1450                 1455             


Thr Tyr  Cys Ile Gln Phe Gly  Phe Met Met Asp Lys  Thr Asn Ile 
    1460                 1465                 1470             


Leu Asn  Ser Glu Gln Val Ile  Val Glu Val Leu Pro  Asn Gln Pro 
    1475                 1480                 1485             


Val Lys  Leu Val Pro Lys Ile  Lys Pro Pro Thr Pro  Ala Val Ser 
    1490                 1495                 1500             


Asn Val  Arg Ser Val Ala Ser  Arg Thr Leu Val Arg  Asp Leu His 
    1505                 1510                 1515             


Leu Ser  Ile Thr Asp Asp Tyr  Asp Asn His Thr Gly  Ile Asp Leu 
    1520                 1525                 1530             


Val Gly  Thr Ile Ile Ala Thr  Ile Lys Gly Ser Asn  Glu Glu Asp 
    1535                 1540                 1545             


Thr Asp  Thr Pro Leu Phe Ile  Gly Lys Val Arg Thr  Leu Glu Phe 
    1550                 1555                 1560             


Pro Phe  Val Asn Gly Ser Ala  Glu Ile Met Ser Leu  Val Leu Ala 
    1565                 1570                 1575             


Glu Ser  Ser Pro Gly Arg Asp  Ser Thr Glu Tyr Phe  Ile Val Phe 
    1580                 1585                 1590             


Glu Pro  Arg Leu Pro Leu Leu  Ser Arg Thr Leu Glu  Pro Tyr Ile 
    1595                 1600                 1605             


Leu Pro  Phe Met Phe Tyr Asn  Asp Val Lys Lys Gln  Gln Gln Met 
    1610                 1615                 1620             


Ala Ala  Leu Thr Lys Glu Lys  Asp Gln Leu Ser Gln  Ser Ile Val 
    1625                 1630                 1635             


Met Tyr  Lys Ser Leu Phe Glu  Ala Ser Gln Gln Leu  Leu Asn Glu 
    1640                 1645                 1650             


Met Lys  Cys Gln Val Glu Glu  Ala Arg Leu Lys Glu  Ala Gln Leu 
    1655                 1660                 1665             


Arg Asn  Glu Leu Lys Ile His  Asn Ile Asp Ile Pro  Thr Thr Gln 
    1670                 1675                 1680             


Gln Val  Pro His Ile Glu Ala  Leu Leu Lys Arg Lys  Leu Ser Glu 
    1685                 1690                 1695             


Gln Glu  Glu Leu Lys Lys Lys  Pro Arg Arg Ser Cys  Thr Leu Pro 
    1700                 1705                 1710             


Asn Tyr  Thr Lys Gly Ser Gly  Asp Val Leu Gly Lys  Ile Ala His 
    1715                 1720                 1725             


Leu Ala  Gln Ile Glu Asp Asp  Arg Ala Ala Met Val  Ile Ser Trp 
    1730                 1735                 1740             


His Leu  Ala Ser Asp Met Asp  Cys Val Val Thr Leu  Thr Thr Asp 
    1745                 1750                 1755             


Ala Ala  Arg Arg Ile Tyr Asp  Glu Thr Gln Gly Arg  Gln Gln Val 
    1760                 1765                 1770             


Leu Pro  Leu Asp Ser Ile Tyr  Lys Lys Thr Leu Pro  Asp Trp Lys 
    1775                 1780                 1785             


Arg Ser  Leu Pro His Phe Arg  Asn Gly Lys Leu Tyr  Phe Lys Pro 
    1790                 1795                 1800             


Ile Gly  Asp Pro Val Phe Ala  Arg Asp Leu Leu Thr  Phe Pro Asp 
    1805                 1810                 1815             


Asn Val  Glu His Cys Glu Thr  Val Phe Gly Met Leu  Leu Gly Asp 
    1820                 1825                 1830             


Thr Ile  Ile Leu Asp Asn Leu  Asp Ala Ala Asn His  Tyr Arg Lys 
    1835                 1840                 1845             


Glu Val  Val Lys Ile Thr His  Cys Pro Thr Leu Leu  Thr Arg Asp 
    1850                 1855                 1860             


Gly Asp  Arg Ile Arg Ser Asn  Gly Lys Phe Gly Gly  Leu Gln Asn 
    1865                 1870                 1875             


Lys Ala  Pro Pro Met Asp Lys  Leu Arg Gly Met Val  Phe Gly Ala 
    1880                 1885                 1890             


Pro Val  Pro Lys Gln Cys Leu  Ile Leu Gly Glu Gln  Ile Asp Leu 
    1895                 1900                 1905             


Leu Gln  Gln Tyr Arg Ser Ala  Val Cys Lys Leu Asp  Ser Val Asn 
    1910                 1915                 1920             


Lys Asp  Leu Asn Ser Gln Leu  Glu Tyr Leu Arg Thr  Pro Asp Met 
    1925                 1930                 1935             


Arg Lys  Lys Lys Gln Glu Leu  Asp Glu His Glu Lys  Asn Leu Lys 
    1940                 1945                 1950             


Leu Ile  Glu Glu Lys Leu Gly  Met Thr Pro Ile Arg  Lys Cys Asn 
    1955                 1960                 1965             


Asp Ser  Leu Arg His Ser Pro  Lys Val Glu Thr Thr  Asp Cys Pro 
    1970                 1975                 1980             


Val Pro  Pro Lys Arg Met Arg  Arg Glu Ala Thr Arg  Gln Asn Arg 
    1985                 1990                 1995             


Ile Ile  Thr Lys Thr Asp Val  
    2000                 2005 


<210>  3
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr 
1               5                   10                  15      


Glu Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp 
            20                  25                  30          


Arg Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly 
        35                  40                  45              


Glu Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu 
    50                  55                  60                  


Gly Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys 
65                  70                  75                  80  


Glu Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr 
                85                  90                  95      


Leu Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys 
            100                 105                 110         


Glu Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly 
        115                 120                 125             


Met Tyr Glu Tyr Tyr Ala Cys Glu Gly Gln Asn Pro Leu Pro Phe Ala 
    130                 135                 140                 


Leu Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile 
145                 150                 155                 160 


Gly Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly 
                165                 170                 175     


Lys Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys 
            180                 185                 190         


Gln Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln 
        195                 200                 205             


Gly Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val 
    210                 215                 220                 


Pro Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys 
225                 230                 235                 240 


Gln Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro 
                245                 250                 255     


Ala Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe 
            260                 265                 270         


Glu Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg 
        275                 280                 285             


Asn Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Phe Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr 
305                 310                 315                 320 


Ala Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys 
                325                 330                 335     


Asn Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr 
            340                 345                 350         


Tyr Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val 
        355                 360                 365             


Glu Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly 
    370                 375                 380                 


Lys Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln 
385                 390                 395                 400 


Thr Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His 
                405                 410                 415     


Val Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe 
            420                 425                 430         


Leu Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys 
        435                 440                 445             


Leu Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala 
    450                 455                 460                 


Ala Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu 
465                 470                 475                 480 


Ile Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys 
                485                 490                 495     


Lys Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala 
            500                 505                 510         


Leu Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe 
        515                 520                 525             


Met Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg 
    530                 535                 540                 


Ile Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe 
                565                 570                 575     


Thr Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys 
            580                 585                 590         


Gln Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile 
        595                 600                 605             


Tyr Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe 
    610                 615                 620                 


Tyr Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu 
625                 630                 635                 640 


Val Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala 
                645                 650                 655     


Leu Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr 
            660                 665                 670         


Val Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg 
        675                 680                 685             


Leu Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu 
    690                 695                 700                 


Pro Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile 
705                 710                 715                 720 


Glu Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr 
                725                 730                 735     


Ser His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu 
            740                 745                 750         


His Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His 
        755                 760                 765             


Gly Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys 
    770                 775                 780                 


Leu Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn 
785                 790                 795                 800 


Ala Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe 
                805                 810                 815     


Ser Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp 
            820                 825                 830         


Leu Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln 
        835                 840                 845             


Asp Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val 
    850                 855                 860                 


Leu Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly 
865                 870                 875                 880 


Pro Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser 
                885                 890                 895     


Cys Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys 
            900                 905                 910         


Glu Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg 
        915                 920                 925             


Arg Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly 
    930                 935                 940                 


Thr Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile 
945                 950                 955                 960 


Thr Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro 
                965                 970                 975     


Asn Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Leu Thr Gly Ser Ala Ile Gln Val  Gln Asn Ile Lys Lys  Asp Gln Thr 
        995                 1000                 1005             


Leu Lys  Ala Arg Ile Glu Ile  Pro Ser Cys Lys Asp  Val Ala Pro 
    1010                 1015                 1020             


Val Glu  Lys Thr Ile Lys Leu  Leu Pro Ser Ser His  Val Ala Arg 
    1025                 1030                 1035             


Leu Gln  Ile Phe Ser Val Glu  Gly Gln Lys Ala Ile  Gln Ile Lys 
    1040                 1045                 1050             


His Gln  Asp Glu Val Asn Trp  Ile Ala Gly Asp Ile  Met His Asn 
    1055                 1060                 1065             


Leu Ile  Phe Gln Met Tyr Asp  Glu Gly Glu Arg Glu  Ile Asn Ile 
    1070                 1075                 1080             


Thr Ser  Ala Leu Ala Glu Lys  Ile Lys Val Asn Trp  Thr Pro Glu 
    1085                 1090                 1095             


Ile Asn  Lys Glu His Leu Leu  Gln Gly Leu Leu Pro  Asp Val Gln 
    1100                 1105                 1110             


Val Pro  Thr Ser Val Lys Asp  Met Arg Tyr Cys Gln  Val Ser Phe 
    1115                 1120                 1125             


Gln Asp  Asp His Val Ser Leu  Glu Ser Ala Phe Thr  Val Arg Pro 
    1130                 1135                 1140             


Leu Pro  Asp Glu Pro Lys His  Leu Lys Cys Glu Met  Lys Gly Gly 
    1145                 1150                 1155             


Lys Thr  Val Gln Met Gly Gln  Glu Leu Gln Gly Glu  Val Val Ile 
    1160                 1165                 1170             


Ile Ile  Thr Asp Gln Tyr Gly  Asn Gln Ile Gln Ala  Phe Ser Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Ser Leu Ser  Ile Ala Gly Val Gly  Leu Asp Ser 
    1190                 1195                 1200             


Ser Asn  Leu Lys Thr Thr Phe  Gln Glu Asn Thr Gln  Ser Ile Ser 
    1205                 1210                 1215             


Val Arg  Gly Ile Lys Phe Ile  Pro Gly Pro Pro Gly  Asn Lys Asp 
    1220                 1225                 1230             


Leu Cys  Phe Thr Trp Arg Glu  Phe Ser Asp Phe Ile  Arg Val Gln 
    1235                 1240                 1245             


Leu Ile  Ser Gly Pro Pro Ala  Lys Leu Leu Leu Ile  Asp Trp Pro 
    1250                 1255                 1260             


Glu Leu  Lys Glu Ser Ile Pro  Val Ile Asn Gly Arg  Asp Leu Gln 
    1265                 1270                 1275             


Asn Pro  Ile Ile Val Gln Leu  Cys Asp Gln Trp Asp  Asn Pro Ala 
    1280                 1285                 1290             


Pro Val  Gln His Val Lys Ile  Ser Leu Thr Lys Ala  Ser Asn Leu 
    1295                 1300                 1305             


Lys Leu  Met Pro Ser Asn Gln  Gln His Lys Thr Asp  Glu Lys Gly 
    1310                 1315                 1320             


Arg Ala  Asn Leu Gly Val Phe  Ser Val Phe Ala Pro  Arg Gly Glu 
    1325                 1330                 1335             


His Thr  Leu Gln Val Lys Ala  Ile Tyr Asn Lys Ser  Ile Ile Glu 
    1340                 1345                 1350             


Gly Pro  Ile Ile Lys Leu Met  Ile Leu Pro Asp Pro  Glu Lys Pro 
    1355                 1360                 1365             


Val Arg  Leu Asn Val Lys Tyr  Asp Lys Asp Ala Ser  Phe Leu Ala 
    1370                 1375                 1380             


Gly Gly  Leu Phe Thr Asp Phe  Met Ile Ser Val Ile  Ser Glu Asp 
    1385                 1390                 1395             


Asp Ser  Ile Ile Lys Asn Ile  Asn Pro Ala Arg Ile  Ser Met Lys 
    1400                 1405                 1410             


Met Trp  Lys Leu Ser Thr Ser  Gly Asn Arg Pro Pro  Ala Asn Ala 
    1415                 1420                 1425             


Glu Thr  Phe Ser Cys Asn Lys  Ile Lys Asp Asn Asp  Lys Glu Asp 
    1430                 1435                 1440             


Gly Cys  Phe Tyr Phe Arg Asp  Lys Val Ile Pro Asn  Lys Val Gly 
    1445                 1450                 1455             


Thr Tyr  Cys Ile Gln Phe Gly  Phe Met Met Asp Lys  Thr Asn Ile 
    1460                 1465                 1470             


Leu Asn  Ser Glu Gln Val Ile  Val Glu Val Leu Pro  Asn Gln Pro 
    1475                 1480                 1485             


Val Lys  Leu Val Pro Lys Ile  Lys Pro Pro Thr Pro  Ala Val Ser 
    1490                 1495                 1500             


Asn Val  Arg Ser Val Ala Ser  Arg Thr Leu Val Arg  Asp Leu His 
    1505                 1510                 1515             


Leu Ser  Ile Thr Asp Asp Tyr  Asp Asn His Thr Gly  Ile Asp Leu 
    1520                 1525                 1530             


Val Gly  Thr Ile Ile Ala Thr  Ile Lys Gly Ser Asn  Glu Glu Asp 
    1535                 1540                 1545             


Thr Asp  Thr Pro Leu Phe Ile  Gly Lys Val Arg Thr  Leu Glu Phe 
    1550                 1555                 1560             


Pro Phe  Val Asn Gly Ser Ala  Glu Ile Met Ser Leu  Val Leu Ala 
    1565                 1570                 1575             


Glu Ser  Ser Pro Gly Arg Asp  Ser Thr Glu Tyr Phe  Ile Val Phe 
    1580                 1585                 1590             


Glu Pro  Arg Leu Pro Leu Leu  Ser Arg Thr Leu Glu  Pro Tyr Ile 
    1595                 1600                 1605             


Leu Pro  Phe Met Phe Tyr Asn  Asp Val Lys Lys Gln  Gln Gln Met 
    1610                 1615                 1620             


Ala Ala  Leu Thr Lys Glu Lys  Asp Gln Leu Ser Gln  Ser Ile Val 
    1625                 1630                 1635             


Met Tyr  Lys Ser Leu Phe Glu  Ala Ser Gln Gln Leu  Leu Asn Glu 
    1640                 1645                 1650             


Met Lys  Cys Gln Val Glu Glu  Ala Arg Leu Lys Glu  Ala Gln Leu 
    1655                 1660                 1665             


Arg Asn  Glu Leu Lys Ile His  Asn Ile Asp Ile Pro  Thr Thr Gln 
    1670                 1675                 1680             


Gln Val  Pro His Ile Glu Ala  Leu Leu Lys Arg Lys  Leu Ser Glu 
    1685                 1690                 1695             


Gln Glu  Glu Leu Lys Lys Lys  Pro Arg Arg Ser Cys  Thr Leu Pro 
    1700                 1705                 1710             


Asn Tyr  Thr Lys Gly Ser Gly  Asp Val Leu Gly Lys  Ile Ala His 
    1715                 1720                 1725             


Leu Ala  Gln Ile Glu Asp Asp  Arg Ala Ala Met Val  Ile Ser Trp 
    1730                 1735                 1740             


His Leu  Ala Ser Asp Met Asp  Cys Val Val Thr Leu  Thr Thr Asp 
    1745                 1750                 1755             


Ala Ala  Arg Arg Ile Tyr Asp  Glu Thr Gln Gly Arg  Gln Gln Val 
    1760                 1765                 1770             


Leu Pro  Leu Asp Ser Ile Tyr  Lys Lys Thr Leu Pro  Asp Trp Lys 
    1775                 1780                 1785             


Arg Ser  Leu Pro His Phe Arg  Asn Gly Lys Leu Tyr  Phe Lys Pro 
    1790                 1795                 1800             


Ile Gly  Asp Pro Val Phe Ala  Arg Asp Leu Leu Thr  Phe Pro Asp 
    1805                 1810                 1815             


Asn Val  Glu His Cys Glu Thr  Val Phe Gly Met Leu  Leu Gly Asp 
    1820                 1825                 1830             


Thr Ile  Ile Leu Asp Asn Leu  Asp Ala Ala Asn His  Tyr Arg Lys 
    1835                 1840                 1845             


Glu Val  Val Lys Ile Thr His  Cys Pro Thr Leu Leu  Thr Arg Asp 
    1850                 1855                 1860             


Gly Asp  Arg Ile Arg Ser Asn  Gly Lys Phe Gly Gly  Leu Gln Asn 
    1865                 1870                 1875             


Lys Ala  Pro Pro Met Asp Lys  Leu Arg Gly Met Val  Phe Gly Ala 
    1880                 1885                 1890             


Pro Val  Pro Lys Gln Cys Leu  Ile Leu Gly Glu Gln  Ile Asp Leu 
    1895                 1900                 1905             


Leu Gln  Gln Tyr Arg Ser Ala  Val Cys Lys Leu Asp  Ser Val Asn 
    1910                 1915                 1920             


Lys Asp  Leu Asn Ser Gln Leu  Glu Tyr Leu Arg Thr  Pro Asp Met 
    1925                 1930                 1935             


Arg Lys  Lys Lys Gln Glu Leu  Asp Glu His Glu Lys  Asn Leu Lys 
    1940                 1945                 1950             


Leu Ile  Glu Glu Lys Leu Gly  Met Thr Pro Ile Arg  Lys Cys Asn 
    1955                 1960                 1965             


Asp Ser  Leu Arg His Ser Pro  Lys Val Glu Thr Thr  Asp Cys Pro 
    1970                 1975                 1980             


Val Pro  Pro Lys Arg Met Arg  Arg Glu Ala Thr Arg  Gln Asn Arg 
    1985                 1990                 1995             


Ile Ile  Thr Lys Thr Asp Val  
    2000                 2005 


<210>  4
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr 
1               5                   10                  15      


Glu Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp 
            20                  25                  30          


Arg Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly 
        35                  40                  45              


Glu Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu 
    50                  55                  60                  


Gly Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys 
65                  70                  75                  80  


Glu Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr 
                85                  90                  95      


Leu Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys 
            100                 105                 110         


Glu Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly 
        115                 120                 125             


Met Tyr Glu Tyr Tyr Ala Asn Glu Gly Gln Asn Pro Leu Pro Phe Ala 
    130                 135                 140                 


Leu Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile 
145                 150                 155                 160 


Gly Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly 
                165                 170                 175     


Lys Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys 
            180                 185                 190         


Gln Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln 
        195                 200                 205             


Gly Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val 
    210                 215                 220                 


Pro Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys 
225                 230                 235                 240 


Gln Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro 
                245                 250                 255     


Ala Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe 
            260                 265                 270         


Glu Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg 
        275                 280                 285             


Asn Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Phe Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr 
305                 310                 315                 320 


Ala Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys 
                325                 330                 335     


Asn Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr 
            340                 345                 350         


Tyr Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val 
        355                 360                 365             


Glu Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly 
    370                 375                 380                 


Lys Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln 
385                 390                 395                 400 


Thr Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His 
                405                 410                 415     


Val Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe 
            420                 425                 430         


Leu Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys 
        435                 440                 445             


Leu Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala 
    450                 455                 460                 


Ala Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu 
465                 470                 475                 480 


Ile Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys 
                485                 490                 495     


Lys Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala 
            500                 505                 510         


Leu Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe 
        515                 520                 525             


Met Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg 
    530                 535                 540                 


Ile Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe 
                565                 570                 575     


Thr Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys 
            580                 585                 590         


Gln Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile 
        595                 600                 605             


Tyr Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe 
    610                 615                 620                 


Tyr Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu 
625                 630                 635                 640 


Val Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala 
                645                 650                 655     


Leu Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr 
            660                 665                 670         


Val Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg 
        675                 680                 685             


Leu Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu 
    690                 695                 700                 


Pro Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile 
705                 710                 715                 720 


Glu Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr 
                725                 730                 735     


Ser His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu 
            740                 745                 750         


His Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His 
        755                 760                 765             


Gly Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys 
    770                 775                 780                 


Leu Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn 
785                 790                 795                 800 


Ala Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe 
                805                 810                 815     


Ser Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp 
            820                 825                 830         


Leu Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln 
        835                 840                 845             


Asp Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val 
    850                 855                 860                 


Leu Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly 
865                 870                 875                 880 


Pro Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser 
                885                 890                 895     


Cys Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys 
            900                 905                 910         


Glu Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg 
        915                 920                 925             


Arg Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly 
    930                 935                 940                 


Thr Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile 
945                 950                 955                 960 


Thr Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro 
                965                 970                 975     


Asn Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Leu Thr Gly Ser Ala Ile Gln Val  Gln Asn Ile Lys Lys  Asp Gln Thr 
        995                 1000                 1005             


Leu Lys  Ala Arg Ile Glu Ile  Pro Ser Cys Lys Asp  Val Ala Pro 
    1010                 1015                 1020             


Val Glu  Lys Thr Ile Lys Leu  Leu Pro Ser Ser His  Val Ala Arg 
    1025                 1030                 1035             


Leu Gln  Ile Phe Ser Val Glu  Gly Gln Lys Ala Ile  Gln Ile Lys 
    1040                 1045                 1050             


His Gln  Asp Glu Val Asn Trp  Ile Ala Gly Asp Ile  Met His Asn 
    1055                 1060                 1065             


Leu Ile  Phe Gln Met Tyr Asp  Glu Gly Glu Arg Glu  Ile Asn Ile 
    1070                 1075                 1080             


Thr Ser  Ala Leu Ala Glu Lys  Ile Lys Val Asn Trp  Thr Pro Glu 
    1085                 1090                 1095             


Ile Asn  Lys Glu His Leu Leu  Gln Gly Leu Leu Pro  Asp Val Gln 
    1100                 1105                 1110             


Val Pro  Thr Ser Val Lys Asp  Met Arg Tyr Cys Gln  Val Ser Phe 
    1115                 1120                 1125             


Gln Asp  Asp His Val Ser Leu  Glu Ser Ala Phe Thr  Val Arg Pro 
    1130                 1135                 1140             


Leu Pro  Asp Glu Pro Lys His  Leu Lys Cys Glu Met  Lys Gly Gly 
    1145                 1150                 1155             


Lys Thr  Val Gln Met Gly Gln  Glu Leu Gln Gly Glu  Val Val Ile 
    1160                 1165                 1170             


Ile Ile  Thr Asp Gln Tyr Gly  Asn Gln Ile Gln Ala  Phe Ser Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Ser Leu Ser  Ile Ala Gly Val Gly  Leu Asp Ser 
    1190                 1195                 1200             


Ser Asn  Leu Lys Thr Thr Phe  Gln Glu Asn Thr Gln  Ser Ile Ser 
    1205                 1210                 1215             


Val Arg  Gly Ile Lys Phe Ile  Pro Gly Pro Pro Gly  Asn Lys Asp 
    1220                 1225                 1230             


Leu Cys  Phe Thr Trp Arg Glu  Phe Ser Asp Phe Ile  Arg Val Gln 
    1235                 1240                 1245             


Leu Ile  Ser Gly Pro Pro Ala  Lys Leu Leu Leu Ile  Asp Trp Pro 
    1250                 1255                 1260             


Glu Leu  Lys Glu Ser Ile Pro  Val Ile Asn Gly Arg  Asp Leu Gln 
    1265                 1270                 1275             


Asn Pro  Ile Ile Val Gln Leu  Cys Asp Gln Trp Asp  Asn Pro Ala 
    1280                 1285                 1290             


Pro Val  Gln His Val Lys Ile  Ser Leu Thr Lys Ala  Ser Asn Leu 
    1295                 1300                 1305             


Lys Leu  Met Pro Ser Asn Gln  Gln His Lys Thr Asp  Glu Lys Gly 
    1310                 1315                 1320             


Arg Ala  Asn Leu Gly Val Phe  Ser Val Phe Ala Pro  Arg Gly Glu 
    1325                 1330                 1335             


His Thr  Leu Gln Val Lys Ala  Ile Tyr Asn Lys Ser  Ile Ile Glu 
    1340                 1345                 1350             


Gly Pro  Ile Ile Lys Leu Met  Ile Leu Pro Asp Pro  Glu Lys Pro 
    1355                 1360                 1365             


Val Arg  Leu Asn Val Lys Tyr  Asp Lys Asp Ala Ser  Phe Leu Ala 
    1370                 1375                 1380             


Gly Gly  Leu Phe Thr Asp Phe  Met Ile Ser Val Ile  Ser Glu Asp 
    1385                 1390                 1395             


Asp Ser  Ile Ile Lys Asn Ile  Asn Pro Ala Arg Ile  Ser Met Lys 
    1400                 1405                 1410             


Met Trp  Lys Leu Ser Thr Ser  Gly Asn Arg Pro Pro  Ala Asn Ala 
    1415                 1420                 1425             


Glu Thr  Phe Ser Cys Asn Lys  Ile Lys Asp Asn Asp  Lys Glu Asp 
    1430                 1435                 1440             


Gly Cys  Phe Tyr Phe Arg Asp  Lys Val Ile Pro Asn  Lys Val Gly 
    1445                 1450                 1455             


Thr Tyr  Cys Ile Gln Phe Gly  Phe Met Met Asp Lys  Thr Asn Ile 
    1460                 1465                 1470             


Leu Asn  Ser Glu Gln Val Ile  Val Glu Val Leu Pro  Asn Gln Pro 
    1475                 1480                 1485             


Val Lys  Leu Val Pro Lys Ile  Lys Pro Pro Thr Pro  Ala Val Ser 
    1490                 1495                 1500             


Asn Val  Arg Ser Val Ala Ser  Arg Thr Leu Val Arg  Asp Leu His 
    1505                 1510                 1515             


Leu Ser  Ile Thr Asp Asp Tyr  Asp Asn His Thr Gly  Ile Asp Leu 
    1520                 1525                 1530             


Val Gly  Thr Ile Ile Ala Thr  Ile Lys Gly Ser Asn  Glu Glu Asp 
    1535                 1540                 1545             


Thr Asp  Thr Pro Leu Phe Ile  Gly Lys Val Arg Thr  Leu Glu Phe 
    1550                 1555                 1560             


Pro Phe  Val Asn Gly Ser Ala  Glu Ile Met Ser Leu  Val Leu Ala 
    1565                 1570                 1575             


Glu Ser  Ser Pro Gly Arg Asp  Ser Thr Glu Tyr Phe  Ile Val Phe 
    1580                 1585                 1590             


Glu Pro  Arg Leu Pro Leu Leu  Ser Arg Thr Leu Glu  Pro Tyr Ile 
    1595                 1600                 1605             


Leu Pro  Phe Met Phe Tyr Asn  Asp Val Lys Lys Gln  Gln Gln Met 
    1610                 1615                 1620             


Ala Ala  Leu Thr Lys Glu Lys  Asp Gln Leu Ser Gln  Ser Ile Val 
    1625                 1630                 1635             


Met Tyr  Lys Ser Leu Phe Glu  Ala Ser Gln Gln Leu  Leu Asn Glu 
    1640                 1645                 1650             


Met Lys  Cys Gln Val Glu Glu  Ala Arg Leu Lys Glu  Ala Gln Leu 
    1655                 1660                 1665             


Arg Asn  Glu Leu Lys Ile His  Asn Ile Asp Ile Pro  Thr Thr Gln 
    1670                 1675                 1680             


Gln Val  Pro His Ile Glu Ala  Leu Leu Lys Arg Lys  Leu Ser Glu 
    1685                 1690                 1695             


Gln Glu  Glu Leu Lys Lys Lys  Pro Arg Arg Ser Cys  Thr Leu Pro 
    1700                 1705                 1710             


Asn Tyr  Thr Lys Gly Ser Gly  Asp Val Leu Gly Lys  Ile Ala His 
    1715                 1720                 1725             


Leu Ala  Gln Ile Glu Asp Asp  Arg Ala Ala Met Val  Ile Ser Trp 
    1730                 1735                 1740             


His Leu  Ala Ser Asp Met Asp  Cys Val Val Thr Leu  Thr Thr Asp 
    1745                 1750                 1755             


Ala Ala  Arg Arg Ile Tyr Asp  Glu Thr Gln Gly Arg  Gln Gln Val 
    1760                 1765                 1770             


Leu Pro  Leu Asp Ser Ile Tyr  Lys Lys Thr Leu Pro  Asp Trp Lys 
    1775                 1780                 1785             


Arg Ser  Leu Pro His Phe Arg  Asn Gly Lys Leu Tyr  Phe Lys Pro 
    1790                 1795                 1800             


Ile Gly  Asp Pro Val Phe Ala  Arg Asp Leu Leu Thr  Phe Pro Asp 
    1805                 1810                 1815             


Asn Val  Glu His Cys Glu Thr  Val Phe Gly Met Leu  Leu Gly Asp 
    1820                 1825                 1830             


Thr Ile  Ile Leu Asp Asn Leu  Asp Ala Ala Asn His  Tyr Arg Lys 
    1835                 1840                 1845             


Glu Val  Val Lys Ile Thr His  Cys Pro Thr Leu Leu  Thr Arg Asp 
    1850                 1855                 1860             


Gly Asp  Arg Ile Arg Ser Asn  Gly Lys Phe Gly Gly  Leu Gln Asn 
    1865                 1870                 1875             


Lys Ala  Pro Pro Met Asp Lys  Leu Arg Gly Met Val  Phe Gly Ala 
    1880                 1885                 1890             


Pro Val  Pro Lys Gln Cys Leu  Ile Leu Gly Glu Gln  Ile Asp Leu 
    1895                 1900                 1905             


Leu Gln  Gln Tyr Arg Ser Ala  Val Cys Lys Leu Asp  Ser Val Asn 
    1910                 1915                 1920             


Lys Asp  Leu Asn Ser Gln Leu  Glu Tyr Leu Arg Thr  Pro Asp Met 
    1925                 1930                 1935             


Arg Lys  Lys Lys Gln Glu Leu  Asp Glu His Glu Lys  Asn Leu Lys 
    1940                 1945                 1950             


Leu Ile  Glu Glu Lys Leu Gly  Met Thr Pro Ile Arg  Lys Cys Asn 
    1955                 1960                 1965             


Asp Ser  Leu Arg His Ser Pro  Lys Val Glu Thr Thr  Asp Cys Pro 
    1970                 1975                 1980             


Val Pro  Pro Lys Arg Met Arg  Arg Glu Ala Thr Arg  Gln Asn Arg 
    1985                 1990                 1995             


Ile Ile  Thr Lys Thr Asp Val  
    2000                 2005 


<210>  5
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr 
1               5                   10                  15      


Glu Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp 
            20                  25                  30          


Arg Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly 
        35                  40                  45              


Glu Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu 
    50                  55                  60                  


Gly Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys 
65                  70                  75                  80  


Glu Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr 
                85                  90                  95      


Leu Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys 
            100                 105                 110         


Glu Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly 
        115                 120                 125             


Met Tyr Glu Tyr Tyr Ala Ser Gly Gly Gln Asn Pro Leu Pro Phe Ala 
    130                 135                 140                 


Leu Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile 
145                 150                 155                 160 


Gly Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly 
                165                 170                 175     


Lys Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys 
            180                 185                 190         


Gln Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln 
        195                 200                 205             


Gly Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val 
    210                 215                 220                 


Pro Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys 
225                 230                 235                 240 


Gln Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro 
                245                 250                 255     


Ala Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe 
            260                 265                 270         


Glu Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg 
        275                 280                 285             


Asn Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Phe Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr 
305                 310                 315                 320 


Ala Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys 
                325                 330                 335     


Asn Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr 
            340                 345                 350         


Tyr Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val 
        355                 360                 365             


Glu Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly 
    370                 375                 380                 


Lys Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln 
385                 390                 395                 400 


Thr Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His 
                405                 410                 415     


Val Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe 
            420                 425                 430         


Leu Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys 
        435                 440                 445             


Leu Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala 
    450                 455                 460                 


Ala Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu 
465                 470                 475                 480 


Ile Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys 
                485                 490                 495     


Lys Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala 
            500                 505                 510         


Leu Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe 
        515                 520                 525             


Met Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg 
    530                 535                 540                 


Ile Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe 
                565                 570                 575     


Thr Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys 
            580                 585                 590         


Gln Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile 
        595                 600                 605             


Tyr Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe 
    610                 615                 620                 


Tyr Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu 
625                 630                 635                 640 


Val Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala 
                645                 650                 655     


Leu Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr 
            660                 665                 670         


Val Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg 
        675                 680                 685             


Leu Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu 
    690                 695                 700                 


Pro Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile 
705                 710                 715                 720 


Glu Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr 
                725                 730                 735     


Ser His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu 
            740                 745                 750         


His Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His 
        755                 760                 765             


Gly Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys 
    770                 775                 780                 


Leu Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn 
785                 790                 795                 800 


Ala Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe 
                805                 810                 815     


Ser Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp 
            820                 825                 830         


Leu Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln 
        835                 840                 845             


Asp Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val 
    850                 855                 860                 


Leu Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly 
865                 870                 875                 880 


Pro Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser 
                885                 890                 895     


Cys Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys 
            900                 905                 910         


Glu Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg 
        915                 920                 925             


Arg Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly 
    930                 935                 940                 


Thr Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile 
945                 950                 955                 960 


Thr Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro 
                965                 970                 975     


Asn Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Leu Thr Gly Ser Ala Ile Gln Val  Gln Asn Ile Lys Lys  Asp Gln Thr 
        995                 1000                 1005             


Leu Lys  Ala Arg Ile Glu Ile  Pro Ser Cys Lys Asp  Val Ala Pro 
    1010                 1015                 1020             


Val Glu  Lys Thr Ile Lys Leu  Leu Pro Ser Ser His  Val Ala Arg 
    1025                 1030                 1035             


Leu Gln  Ile Phe Ser Val Glu  Gly Gln Lys Ala Ile  Gln Ile Lys 
    1040                 1045                 1050             


His Gln  Asp Glu Val Asn Trp  Ile Ala Gly Asp Ile  Met His Asn 
    1055                 1060                 1065             


Leu Ile  Phe Gln Met Tyr Asp  Glu Gly Glu Arg Glu  Ile Asn Ile 
    1070                 1075                 1080             


Thr Ser  Ala Leu Ala Glu Lys  Ile Lys Val Asn Trp  Thr Pro Glu 
    1085                 1090                 1095             


Ile Asn  Lys Glu His Leu Leu  Gln Gly Leu Leu Pro  Asp Val Gln 
    1100                 1105                 1110             


Val Pro  Thr Ser Val Lys Asp  Met Arg Tyr Cys Gln  Val Ser Phe 
    1115                 1120                 1125             


Gln Asp  Asp His Val Ser Leu  Glu Ser Ala Phe Thr  Val Arg Pro 
    1130                 1135                 1140             


Leu Pro  Asp Glu Pro Lys His  Leu Lys Cys Glu Met  Lys Gly Gly 
    1145                 1150                 1155             


Lys Thr  Val Gln Met Gly Gln  Glu Leu Gln Gly Glu  Val Val Ile 
    1160                 1165                 1170             


Ile Ile  Thr Asp Gln Tyr Gly  Asn Gln Ile Gln Ala  Phe Ser Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Ser Leu Ser  Ile Ala Gly Val Gly  Leu Asp Ser 
    1190                 1195                 1200             


Ser Asn  Leu Lys Thr Thr Phe  Gln Glu Asn Thr Gln  Ser Ile Ser 
    1205                 1210                 1215             


Val Arg  Gly Ile Lys Phe Ile  Pro Gly Pro Pro Gly  Asn Lys Asp 
    1220                 1225                 1230             


Leu Cys  Phe Thr Trp Arg Glu  Phe Ser Asp Phe Ile  Arg Val Gln 
    1235                 1240                 1245             


Leu Ile  Ser Gly Pro Pro Ala  Lys Leu Leu Leu Ile  Asp Trp Pro 
    1250                 1255                 1260             


Glu Leu  Lys Glu Ser Ile Pro  Val Ile Asn Gly Arg  Asp Leu Gln 
    1265                 1270                 1275             


Asn Pro  Ile Ile Val Gln Leu  Cys Asp Gln Trp Asp  Asn Pro Ala 
    1280                 1285                 1290             


Pro Val  Gln His Val Lys Ile  Ser Leu Thr Lys Ala  Ser Asn Leu 
    1295                 1300                 1305             


Lys Leu  Met Pro Ser Asn Gln  Gln His Lys Thr Asp  Glu Lys Gly 
    1310                 1315                 1320             


Arg Ala  Asn Leu Gly Val Phe  Ser Val Phe Ala Pro  Arg Gly Glu 
    1325                 1330                 1335             


His Thr  Leu Gln Val Lys Ala  Ile Tyr Asn Lys Ser  Ile Ile Glu 
    1340                 1345                 1350             


Gly Pro  Ile Ile Lys Leu Met  Ile Leu Pro Asp Pro  Glu Lys Pro 
    1355                 1360                 1365             


Val Arg  Leu Asn Val Lys Tyr  Asp Lys Asp Ala Ser  Phe Leu Ala 
    1370                 1375                 1380             


Gly Gly  Leu Phe Thr Asp Phe  Met Ile Ser Val Ile  Ser Glu Asp 
    1385                 1390                 1395             


Asp Ser  Ile Ile Lys Asn Ile  Asn Pro Ala Arg Ile  Ser Met Lys 
    1400                 1405                 1410             


Met Trp  Lys Leu Ser Thr Ser  Gly Asn Arg Pro Pro  Ala Asn Ala 
    1415                 1420                 1425             


Glu Thr  Phe Ser Cys Asn Lys  Ile Lys Asp Asn Asp  Lys Glu Asp 
    1430                 1435                 1440             


Gly Cys  Phe Tyr Phe Arg Asp  Lys Val Ile Pro Asn  Lys Val Gly 
    1445                 1450                 1455             


Thr Tyr  Cys Ile Gln Phe Gly  Phe Met Met Asp Lys  Thr Asn Ile 
    1460                 1465                 1470             


Leu Asn  Ser Glu Gln Val Ile  Val Glu Val Leu Pro  Asn Gln Pro 
    1475                 1480                 1485             


Val Lys  Leu Val Pro Lys Ile  Lys Pro Pro Thr Pro  Ala Val Ser 
    1490                 1495                 1500             


Asn Val  Arg Ser Val Ala Ser  Arg Thr Leu Val Arg  Asp Leu His 
    1505                 1510                 1515             


Leu Ser  Ile Thr Asp Asp Tyr  Asp Asn His Thr Gly  Ile Asp Leu 
    1520                 1525                 1530             


Val Gly  Thr Ile Ile Ala Thr  Ile Lys Gly Ser Asn  Glu Glu Asp 
    1535                 1540                 1545             


Thr Asp  Thr Pro Leu Phe Ile  Gly Lys Val Arg Thr  Leu Glu Phe 
    1550                 1555                 1560             


Pro Phe  Val Asn Gly Ser Ala  Glu Ile Met Ser Leu  Val Leu Ala 
    1565                 1570                 1575             


Glu Ser  Ser Pro Gly Arg Asp  Ser Thr Glu Tyr Phe  Ile Val Phe 
    1580                 1585                 1590             


Glu Pro  Arg Leu Pro Leu Leu  Ser Arg Thr Leu Glu  Pro Tyr Ile 
    1595                 1600                 1605             


Leu Pro  Phe Met Phe Tyr Asn  Asp Val Lys Lys Gln  Gln Gln Met 
    1610                 1615                 1620             


Ala Ala  Leu Thr Lys Glu Lys  Asp Gln Leu Ser Gln  Ser Ile Val 
    1625                 1630                 1635             


Met Tyr  Lys Ser Leu Phe Glu  Ala Ser Gln Gln Leu  Leu Asn Glu 
    1640                 1645                 1650             


Met Lys  Cys Gln Val Glu Glu  Ala Arg Leu Lys Glu  Ala Gln Leu 
    1655                 1660                 1665             


Arg Asn  Glu Leu Lys Ile His  Asn Ile Asp Ile Pro  Thr Thr Gln 
    1670                 1675                 1680             


Gln Val  Pro His Ile Glu Ala  Leu Leu Lys Arg Lys  Leu Ser Glu 
    1685                 1690                 1695             


Gln Glu  Glu Leu Lys Lys Lys  Pro Arg Arg Ser Cys  Thr Leu Pro 
    1700                 1705                 1710             


Asn Tyr  Thr Lys Gly Ser Gly  Asp Val Leu Gly Lys  Ile Ala His 
    1715                 1720                 1725             


Leu Ala  Gln Ile Glu Asp Asp  Arg Ala Ala Met Val  Ile Ser Trp 
    1730                 1735                 1740             


His Leu  Ala Ser Asp Met Asp  Cys Val Val Thr Leu  Thr Thr Asp 
    1745                 1750                 1755             


Ala Ala  Arg Arg Ile Tyr Asp  Glu Thr Gln Gly Arg  Gln Gln Val 
    1760                 1765                 1770             


Leu Pro  Leu Asp Ser Ile Tyr  Lys Lys Thr Leu Pro  Asp Trp Lys 
    1775                 1780                 1785             


Arg Ser  Leu Pro His Phe Arg  Asn Gly Lys Leu Tyr  Phe Lys Pro 
    1790                 1795                 1800             


Ile Gly  Asp Pro Val Phe Ala  Arg Asp Leu Leu Thr  Phe Pro Asp 
    1805                 1810                 1815             


Asn Val  Glu His Cys Glu Thr  Val Phe Gly Met Leu  Leu Gly Asp 
    1820                 1825                 1830             


Thr Ile  Ile Leu Asp Asn Leu  Asp Ala Ala Asn His  Tyr Arg Lys 
    1835                 1840                 1845             


Glu Val  Val Lys Ile Thr His  Cys Pro Thr Leu Leu  Thr Arg Asp 
    1850                 1855                 1860             


Gly Asp  Arg Ile Arg Ser Asn  Gly Lys Phe Gly Gly  Leu Gln Asn 
    1865                 1870                 1875             


Lys Ala  Pro Pro Met Asp Lys  Leu Arg Gly Met Val  Phe Gly Ala 
    1880                 1885                 1890             


Pro Val  Pro Lys Gln Cys Leu  Ile Leu Gly Glu Gln  Ile Asp Leu 
    1895                 1900                 1905             


Leu Gln  Gln Tyr Arg Ser Ala  Val Cys Lys Leu Asp  Ser Val Asn 
    1910                 1915                 1920             


Lys Asp  Leu Asn Ser Gln Leu  Glu Tyr Leu Arg Thr  Pro Asp Met 
    1925                 1930                 1935             


Arg Lys  Lys Lys Gln Glu Leu  Asp Glu His Glu Lys  Asn Leu Lys 
    1940                 1945                 1950             


Leu Ile  Glu Glu Lys Leu Gly  Met Thr Pro Ile Arg  Lys Cys Asn 
    1955                 1960                 1965             


Asp Ser  Leu Arg His Ser Pro  Lys Val Glu Thr Thr  Asp Cys Pro 
    1970                 1975                 1980             


Val Pro  Pro Lys Arg Met Arg  Arg Glu Ala Thr Arg  Gln Asn Arg 
    1985                 1990                 1995             


Ile Ile  Thr Lys Thr Asp Val  
    2000                 2005 


<210>  6
<211>  2004
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr Glu 
1               5                   10                  15      


Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp Arg 
            20                  25                  30          


Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly Glu 
        35                  40                  45              


Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu Gly 
    50                  55                  60                  


Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys Glu 
65                  70                  75                  80  


Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr Leu 
                85                  90                  95      


Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys Glu 
            100                 105                 110         


Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly Met 
        115                 120                 125             


Tyr Glu Tyr Tyr Ala Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala Leu 
    130                 135                 140                 


Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile Gly 
145                 150                 155                 160 


Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly Lys 
                165                 170                 175     


Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys Gln 
            180                 185                 190         


Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln Gly 
        195                 200                 205             


Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val Pro 
    210                 215                 220                 


Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys Gln 
225                 230                 235                 240 


Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro Ala 
                245                 250                 255     


Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe Glu 
            260                 265                 270         


Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg Asn 
        275                 280                 285             


Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg Phe 
    290                 295                 300                 


Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr Ala 
305                 310                 315                 320 


Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys Asn 
                325                 330                 335     


Tyr Phe His Leu Ser Thr Arg Gln Leu Ala His Ile Tyr His Tyr Tyr 
            340                 345                 350         


Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val Glu 
        355                 360                 365             


Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly Lys 
    370                 375                 380                 


Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln Thr 
385                 390                 395                 400 


Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His Val 
                405                 410                 415     


Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe Leu 
            420                 425                 430         


Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys Leu 
        435                 440                 445             


Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala Ala 
    450                 455                 460                 


Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu Ile 
465                 470                 475                 480 


Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys Lys 
                485                 490                 495     


Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala Leu 
            500                 505                 510         


Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe Met 
        515                 520                 525             


Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg Ile 
    530                 535                 540                 


Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala Leu 
545                 550                 555                 560 


Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe Thr 
                565                 570                 575     


Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys Gln 
            580                 585                 590         


Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile Tyr 
        595                 600                 605             


Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe Tyr 
    610                 615                 620                 


Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu Val 
625                 630                 635                 640 


Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala Leu 
                645                 650                 655     


Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr Val 
            660                 665                 670         


Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg Leu 
        675                 680                 685             


Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu Pro 
    690                 695                 700                 


Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile Glu 
705                 710                 715                 720 


Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr Ser 
                725                 730                 735     


His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu His 
            740                 745                 750         


Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His Gly 
        755                 760                 765             


Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys Leu 
    770                 775                 780                 


Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn Ala 
785                 790                 795                 800 


Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe Ser 
                805                 810                 815     


Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp Leu 
            820                 825                 830         


Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln Asp 
        835                 840                 845             


Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val Leu 
    850                 855                 860                 


Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly Pro 
865                 870                 875                 880 


Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser Cys 
                885                 890                 895     


Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys Glu 
            900                 905                 910         


Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg Arg 
        915                 920                 925             


Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly Thr 
    930                 935                 940                 


Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile Thr 
945                 950                 955                 960 


Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro Asn 
                965                 970                 975     


Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile Leu 
            980                 985                 990         


Thr Gly Ser Ala Ile Gln Val Gln  Asn Ile Lys Lys Asp  Gln Thr Leu 
        995                 1000                 1005             


Lys Ala  Arg Ile Glu Ile Pro  Ser Cys Lys Asp Val  Ala Pro Val 
    1010                 1015                 1020             


Glu Lys  Thr Ile Lys Leu Leu  Pro Ser Ser His Val  Ala Arg Leu 
    1025                 1030                 1035             


Gln Ile  Phe Ser Val Glu Gly  Gln Lys Ala Ile Gln  Ile Lys His 
    1040                 1045                 1050             


Gln Asp  Glu Val Asn Trp Ile  Ala Gly Asp Ile Met  His Asn Leu 
    1055                 1060                 1065             


Ile Phe  Gln Met Tyr Asp Glu  Gly Glu Arg Glu Ile  Asn Ile Thr 
    1070                 1075                 1080             


Ser Ala  Leu Ala Glu Lys Ile  Lys Val Asn Trp Thr  Pro Glu Ile 
    1085                 1090                 1095             


Asn Lys  Glu His Leu Leu Gln  Gly Leu Leu Pro Asp  Val Gln Val 
    1100                 1105                 1110             


Pro Thr  Ser Val Lys Asp Met  Arg Tyr Cys Gln Val  Ser Phe Gln 
    1115                 1120                 1125             


Asp Asp  His Val Ser Leu Glu  Ser Ala Phe Thr Val  Arg Pro Leu 
    1130                 1135                 1140             


Pro Asp  Glu Pro Lys His Leu  Lys Cys Glu Met Lys  Gly Gly Lys 
    1145                 1150                 1155             


Thr Val  Gln Met Gly Gln Glu  Leu Gln Gly Glu Val  Val Ile Ile 
    1160                 1165                 1170             


Ile Thr  Asp Gln Tyr Gly Asn  Gln Ile Gln Ala Phe  Ser Pro Ser 
    1175                 1180                 1185             


Ser Leu  Ser Ser Leu Ser Ile  Ala Gly Val Gly Leu  Asp Ser Ser 
    1190                 1195                 1200             


Asn Leu  Lys Thr Thr Phe Gln  Glu Asn Thr Gln Ser  Ile Ser Val 
    1205                 1210                 1215             


Arg Gly  Ile Lys Phe Ile Pro  Gly Pro Pro Gly Asn  Lys Asp Leu 
    1220                 1225                 1230             


Cys Phe  Thr Trp Arg Glu Phe  Ser Asp Phe Ile Arg  Val Gln Leu 
    1235                 1240                 1245             


Ile Ser  Gly Pro Pro Ala Lys  Leu Leu Leu Ile Asp  Trp Pro Glu 
    1250                 1255                 1260             


Leu Lys  Glu Ser Ile Pro Val  Ile Asn Gly Arg Asp  Leu Gln Asn 
    1265                 1270                 1275             


Pro Ile  Ile Val Gln Leu Cys  Asp Gln Trp Asp Asn  Pro Ala Pro 
    1280                 1285                 1290             


Val Gln  His Val Lys Ile Ser  Leu Thr Lys Ala Ser  Asn Leu Lys 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Gln Gln  His Lys Thr Asp Glu  Lys Gly Arg 
    1310                 1315                 1320             


Ala Asn  Leu Gly Val Phe Ser  Val Phe Ala Pro Arg  Gly Glu His 
    1325                 1330                 1335             


Thr Leu  Gln Val Lys Ala Ile  Tyr Asn Lys Ser Ile  Ile Glu Gly 
    1340                 1345                 1350             


Pro Ile  Ile Lys Leu Met Ile  Leu Pro Asp Pro Glu  Lys Pro Val 
    1355                 1360                 1365             


Arg Leu  Asn Val Lys Tyr Asp  Lys Asp Ala Ser Phe  Leu Ala Gly 
    1370                 1375                 1380             


Gly Leu  Phe Thr Asp Phe Met  Ile Ser Val Ile Ser  Glu Asp Asp 
    1385                 1390                 1395             


Ser Ile  Ile Lys Asn Ile Asn  Pro Ala Arg Ile Ser  Met Lys Met 
    1400                 1405                 1410             


Trp Lys  Leu Ser Thr Ser Gly  Asn Arg Pro Pro Ala  Asn Ala Glu 
    1415                 1420                 1425             


Thr Phe  Ser Cys Asn Lys Ile  Lys Asp Asn Asp Lys  Glu Asp Gly 
    1430                 1435                 1440             


Cys Phe  Tyr Phe Arg Asp Lys  Val Ile Pro Asn Lys  Val Gly Thr 
    1445                 1450                 1455             


Tyr Cys  Ile Gln Phe Gly Phe  Met Met Asp Lys Thr  Asn Ile Leu 
    1460                 1465                 1470             


Asn Ser  Glu Gln Val Ile Val  Glu Val Leu Pro Asn  Gln Pro Val 
    1475                 1480                 1485             


Lys Leu  Val Pro Lys Ile Lys  Pro Pro Thr Pro Ala  Val Ser Asn 
    1490                 1495                 1500             


Val Arg  Ser Val Ala Ser Arg  Thr Leu Val Arg Asp  Leu His Leu 
    1505                 1510                 1515             


Ser Ile  Thr Asp Asp Tyr Asp  Asn His Thr Gly Ile  Asp Leu Val 
    1520                 1525                 1530             


Gly Thr  Ile Ile Ala Thr Ile  Lys Gly Ser Asn Glu  Glu Asp Thr 
    1535                 1540                 1545             


Asp Thr  Pro Leu Phe Ile Gly  Lys Val Arg Thr Leu  Glu Phe Pro 
    1550                 1555                 1560             


Phe Val  Asn Gly Ser Ala Glu  Ile Met Ser Leu Val  Leu Ala Glu 
    1565                 1570                 1575             


Ser Ser  Pro Gly Arg Asp Ser  Thr Glu Tyr Phe Ile  Val Phe Glu 
    1580                 1585                 1590             


Pro Arg  Leu Pro Leu Leu Ser  Arg Thr Leu Glu Pro  Tyr Ile Leu 
    1595                 1600                 1605             


Pro Phe  Met Phe Tyr Asn Asp  Val Lys Lys Gln Gln  Gln Met Ala 
    1610                 1615                 1620             


Ala Leu  Thr Lys Glu Lys Asp  Gln Leu Ser Gln Ser  Ile Val Met 
    1625                 1630                 1635             


Tyr Lys  Ser Leu Phe Glu Ala  Ser Gln Gln Leu Leu  Asn Glu Met 
    1640                 1645                 1650             


Lys Cys  Gln Val Glu Glu Ala  Arg Leu Lys Glu Ala  Gln Leu Arg 
    1655                 1660                 1665             


Asn Glu  Leu Lys Ile His Asn  Ile Asp Ile Pro Thr  Thr Gln Gln 
    1670                 1675                 1680             


Val Pro  His Ile Glu Ala Leu  Leu Lys Arg Lys Leu  Ser Glu Gln 
    1685                 1690                 1695             


Glu Glu  Leu Lys Lys Lys Pro  Arg Arg Ser Cys Thr  Leu Pro Asn 
    1700                 1705                 1710             


Tyr Thr  Lys Gly Ser Gly Asp  Val Leu Gly Lys Ile  Ala His Leu 
    1715                 1720                 1725             


Ala Gln  Ile Glu Asp Asp Arg  Ala Ala Met Val Ile  Ser Trp His 
    1730                 1735                 1740             


Leu Ala  Ser Asp Met Asp Cys  Val Val Thr Leu Thr  Thr Asp Ala 
    1745                 1750                 1755             


Ala Arg  Arg Ile Tyr Asp Glu  Thr Gln Gly Arg Gln  Gln Val Leu 
    1760                 1765                 1770             


Pro Leu  Asp Ser Ile Tyr Lys  Lys Thr Leu Pro Asp  Trp Lys Arg 
    1775                 1780                 1785             


Ser Leu  Pro His Phe Arg Asn  Gly Lys Leu Tyr Phe  Lys Pro Ile 
    1790                 1795                 1800             


Gly Asp  Pro Val Phe Ala Arg  Asp Leu Leu Thr Phe  Pro Asp Asn 
    1805                 1810                 1815             


Val Glu  His Cys Glu Thr Val  Phe Gly Met Leu Leu  Gly Asp Thr 
    1820                 1825                 1830             


Ile Ile  Leu Asp Asn Leu Asp  Ala Ala Asn His Tyr  Arg Lys Glu 
    1835                 1840                 1845             


Val Val  Lys Ile Thr His Cys  Pro Thr Leu Leu Thr  Arg Asp Gly 
    1850                 1855                 1860             


Asp Arg  Ile Arg Ser Asn Gly  Lys Phe Gly Gly Leu  Gln Asn Lys 
    1865                 1870                 1875             


Ala Pro  Pro Met Asp Lys Leu  Arg Gly Met Val Phe  Gly Ala Pro 
    1880                 1885                 1890             


Val Pro  Lys Gln Cys Leu Ile  Leu Gly Glu Gln Ile  Asp Leu Leu 
    1895                 1900                 1905             


Gln Gln  Tyr Arg Ser Ala Val  Cys Lys Leu Asp Ser  Val Asn Lys 
    1910                 1915                 1920             


Asp Leu  Asn Ser Gln Leu Glu  Tyr Leu Arg Thr Pro  Asp Met Arg 
    1925                 1930                 1935             


Lys Lys  Lys Gln Glu Leu Asp  Glu His Glu Lys Asn  Leu Lys Leu 
    1940                 1945                 1950             


Ile Glu  Glu Lys Leu Gly Met  Thr Pro Ile Arg Lys  Cys Asn Asp 
    1955                 1960                 1965             


Ser Leu  Arg His Ser Pro Lys  Val Glu Thr Thr Asp  Cys Pro Val 
    1970                 1975                 1980             


Pro Pro  Lys Arg Met Arg Arg  Glu Ala Thr Arg Gln  Asn Arg Ile 
    1985                 1990                 1995             


Ile Thr  Lys Thr Asp Val 
    2000                 


<210>  7
<211>  2004
<212>  PRT
<213>  Homo Sapiens

<400>  7

Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr Glu 
1               5                   10                  15      


Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp Arg 
            20                  25                  30          


Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly Glu 
        35                  40                  45              


Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu Gly 
    50                  55                  60                  


Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys Glu 
65                  70                  75                  80  


Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr Leu 
                85                  90                  95      


Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys Glu 
            100                 105                 110         


Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly Met 
        115                 120                 125             


Tyr Glu Tyr Tyr Ala Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala Leu 
    130                 135                 140                 


Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile Gly 
145                 150                 155                 160 


Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly Lys 
                165                 170                 175     


Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys Gln 
            180                 185                 190         


Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln Gly 
        195                 200                 205             


Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val Pro 
    210                 215                 220                 


Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys Gln 
225                 230                 235                 240 


Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro Ala 
                245                 250                 255     


Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe Glu 
            260                 265                 270         


Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg Asn 
        275                 280                 285             


Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg Phe 
    290                 295                 300                 


Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr Ala 
305                 310                 315                 320 


Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys Asn 
                325                 330                 335     


Tyr Phe His Leu Trp Thr Arg Gln Leu Ala Arg Ile Tyr His Tyr Tyr 
            340                 345                 350         


Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val Glu 
        355                 360                 365             


Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly Lys 
    370                 375                 380                 


Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln Thr 
385                 390                 395                 400 


Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His Val 
                405                 410                 415     


Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe Leu 
            420                 425                 430         


Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys Leu 
        435                 440                 445             


Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala Ala 
    450                 455                 460                 


Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu Ile 
465                 470                 475                 480 


Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys Lys 
                485                 490                 495     


Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala Leu 
            500                 505                 510         


Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe Met 
        515                 520                 525             


Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg Ile 
    530                 535                 540                 


Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala Leu 
545                 550                 555                 560 


Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe Thr 
                565                 570                 575     


Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys Gln 
            580                 585                 590         


Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile Tyr 
        595                 600                 605             


Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe Tyr 
    610                 615                 620                 


Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu Val 
625                 630                 635                 640 


Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala Leu 
                645                 650                 655     


Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr Val 
            660                 665                 670         


Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg Leu 
        675                 680                 685             


Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu Pro 
    690                 695                 700                 


Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile Glu 
705                 710                 715                 720 


Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr Ser 
                725                 730                 735     


His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu His 
            740                 745                 750         


Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His Gly 
        755                 760                 765             


Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys Leu 
    770                 775                 780                 


Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn Ala 
785                 790                 795                 800 


Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe Ser 
                805                 810                 815     


Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp Leu 
            820                 825                 830         


Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln Asp 
        835                 840                 845             


Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val Leu 
    850                 855                 860                 


Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly Pro 
865                 870                 875                 880 


Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser Cys 
                885                 890                 895     


Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys Glu 
            900                 905                 910         


Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg Arg 
        915                 920                 925             


Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly Thr 
    930                 935                 940                 


Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile Thr 
945                 950                 955                 960 


Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro Asn 
                965                 970                 975     


Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile Leu 
            980                 985                 990         


Thr Gly Ser Ala Ile Gln Val Gln  Asn Ile Lys Lys Asp  Gln Thr Leu 
        995                 1000                 1005             


Lys Ala  Arg Ile Glu Ile Pro  Ser Cys Lys Asp Val  Ala Pro Val 
    1010                 1015                 1020             


Glu Lys  Thr Ile Lys Leu Leu  Pro Ser Ser His Val  Ala Arg Leu 
    1025                 1030                 1035             


Gln Ile  Phe Ser Val Glu Gly  Gln Lys Ala Ile Gln  Ile Lys His 
    1040                 1045                 1050             


Gln Asp  Glu Val Asn Trp Ile  Ala Gly Asp Ile Met  His Asn Leu 
    1055                 1060                 1065             


Ile Phe  Gln Met Tyr Asp Glu  Gly Glu Arg Glu Ile  Asn Ile Thr 
    1070                 1075                 1080             


Ser Ala  Leu Ala Glu Lys Ile  Lys Val Asn Trp Thr  Pro Glu Ile 
    1085                 1090                 1095             


Asn Lys  Glu His Leu Leu Gln  Gly Leu Leu Pro Asp  Val Gln Val 
    1100                 1105                 1110             


Pro Thr  Ser Val Lys Asp Met  Arg Tyr Cys Gln Val  Ser Phe Gln 
    1115                 1120                 1125             


Asp Asp  His Val Ser Leu Glu  Ser Ala Phe Thr Val  Arg Pro Leu 
    1130                 1135                 1140             


Pro Asp  Glu Pro Lys His Leu  Lys Cys Glu Met Lys  Gly Gly Lys 
    1145                 1150                 1155             


Thr Val  Gln Met Gly Gln Glu  Leu Gln Gly Glu Val  Val Ile Ile 
    1160                 1165                 1170             


Ile Thr  Asp Gln Tyr Gly Asn  Gln Ile Gln Ala Phe  Ser Pro Ser 
    1175                 1180                 1185             


Ser Leu  Ser Ser Leu Ser Ile  Ala Gly Val Gly Leu  Asp Ser Ser 
    1190                 1195                 1200             


Asn Leu  Lys Thr Thr Phe Gln  Glu Asn Thr Gln Ser  Ile Ser Val 
    1205                 1210                 1215             


Arg Gly  Ile Lys Phe Ile Pro  Gly Pro Pro Gly Asn  Lys Asp Leu 
    1220                 1225                 1230             


Cys Phe  Thr Trp Arg Glu Phe  Ser Asp Phe Ile Arg  Val Gln Leu 
    1235                 1240                 1245             


Ile Ser  Gly Pro Pro Ala Lys  Leu Leu Leu Ile Asp  Trp Pro Glu 
    1250                 1255                 1260             


Leu Lys  Glu Ser Ile Pro Val  Ile Asn Gly Arg Asp  Leu Gln Asn 
    1265                 1270                 1275             


Pro Ile  Ile Val Gln Leu Cys  Asp Gln Trp Asp Asn  Pro Ala Pro 
    1280                 1285                 1290             


Val Gln  His Val Lys Ile Ser  Leu Thr Lys Ala Ser  Asn Leu Lys 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Gln Gln  His Lys Thr Asp Glu  Lys Gly Arg 
    1310                 1315                 1320             


Ala Asn  Leu Gly Val Phe Ser  Val Phe Ala Pro Arg  Gly Glu His 
    1325                 1330                 1335             


Thr Leu  Gln Val Lys Ala Ile  Tyr Asn Lys Ser Ile  Ile Glu Gly 
    1340                 1345                 1350             


Pro Ile  Ile Lys Leu Met Ile  Leu Pro Asp Pro Glu  Lys Pro Val 
    1355                 1360                 1365             


Arg Leu  Asn Val Lys Tyr Asp  Lys Asp Ala Ser Phe  Leu Ala Gly 
    1370                 1375                 1380             


Gly Leu  Phe Thr Asp Phe Met  Ile Ser Val Ile Ser  Glu Asp Asp 
    1385                 1390                 1395             


Ser Ile  Ile Lys Asn Ile Asn  Pro Ala Arg Ile Ser  Met Lys Met 
    1400                 1405                 1410             


Trp Lys  Leu Ser Thr Ser Gly  Asn Arg Pro Pro Ala  Asn Ala Glu 
    1415                 1420                 1425             


Thr Phe  Ser Cys Asn Lys Ile  Lys Asp Asn Asp Lys  Glu Asp Gly 
    1430                 1435                 1440             


Cys Phe  Tyr Phe Arg Asp Lys  Val Ile Pro Asn Lys  Val Gly Thr 
    1445                 1450                 1455             


Tyr Cys  Ile Gln Phe Gly Phe  Met Met Asp Lys Thr  Asn Ile Leu 
    1460                 1465                 1470             


Asn Ser  Glu Gln Val Ile Val  Glu Val Leu Pro Asn  Gln Pro Val 
    1475                 1480                 1485             


Lys Leu  Val Pro Lys Ile Lys  Pro Pro Thr Pro Ala  Val Ser Asn 
    1490                 1495                 1500             


Val Arg  Ser Val Ala Ser Arg  Thr Leu Val Arg Asp  Leu His Leu 
    1505                 1510                 1515             


Ser Ile  Thr Asp Asp Tyr Asp  Asn His Thr Gly Ile  Asp Leu Val 
    1520                 1525                 1530             


Gly Thr  Ile Ile Ala Thr Ile  Lys Gly Ser Asn Glu  Glu Asp Thr 
    1535                 1540                 1545             


Asp Thr  Pro Leu Phe Ile Gly  Lys Val Arg Thr Leu  Glu Phe Pro 
    1550                 1555                 1560             


Phe Val  Asn Gly Ser Ala Glu  Ile Met Ser Leu Val  Leu Ala Glu 
    1565                 1570                 1575             


Ser Ser  Pro Gly Arg Asp Ser  Thr Glu Tyr Phe Ile  Val Phe Glu 
    1580                 1585                 1590             


Pro Arg  Leu Pro Leu Leu Ser  Arg Thr Leu Glu Pro  Tyr Ile Leu 
    1595                 1600                 1605             


Pro Phe  Met Phe Tyr Asn Asp  Val Lys Lys Gln Gln  Gln Met Ala 
    1610                 1615                 1620             


Ala Leu  Thr Lys Glu Lys Asp  Gln Leu Ser Gln Ser  Ile Val Met 
    1625                 1630                 1635             


Tyr Lys  Ser Leu Phe Glu Ala  Ser Gln Gln Leu Leu  Asn Glu Met 
    1640                 1645                 1650             


Lys Cys  Gln Val Glu Glu Ala  Arg Leu Lys Glu Ala  Gln Leu Arg 
    1655                 1660                 1665             


Asn Glu  Leu Lys Ile His Asn  Ile Asp Ile Pro Thr  Thr Gln Gln 
    1670                 1675                 1680             


Val Pro  His Ile Glu Ala Leu  Leu Lys Arg Lys Leu  Ser Glu Gln 
    1685                 1690                 1695             


Glu Glu  Leu Lys Lys Lys Pro  Arg Arg Ser Cys Thr  Leu Pro Asn 
    1700                 1705                 1710             


Tyr Thr  Lys Gly Ser Gly Asp  Val Leu Gly Lys Ile  Ala His Leu 
    1715                 1720                 1725             


Ala Gln  Ile Glu Asp Asp Arg  Ala Ala Met Val Ile  Ser Trp His 
    1730                 1735                 1740             


Leu Ala  Ser Asp Met Asp Cys  Val Val Thr Leu Thr  Thr Asp Ala 
    1745                 1750                 1755             


Ala Arg  Arg Ile Tyr Asp Glu  Thr Gln Gly Arg Gln  Gln Val Leu 
    1760                 1765                 1770             


Pro Leu  Asp Ser Ile Tyr Lys  Lys Thr Leu Pro Asp  Trp Lys Arg 
    1775                 1780                 1785             


Ser Leu  Pro His Phe Arg Asn  Gly Lys Leu Tyr Phe  Lys Pro Ile 
    1790                 1795                 1800             


Gly Asp  Pro Val Phe Ala Arg  Asp Leu Leu Thr Phe  Pro Asp Asn 
    1805                 1810                 1815             


Val Glu  His Cys Glu Thr Val  Phe Gly Met Leu Leu  Gly Asp Thr 
    1820                 1825                 1830             


Ile Ile  Leu Asp Asn Leu Asp  Ala Ala Asn His Tyr  Arg Lys Glu 
    1835                 1840                 1845             


Val Val  Lys Ile Thr His Cys  Pro Thr Leu Leu Thr  Arg Asp Gly 
    1850                 1855                 1860             


Asp Arg  Ile Arg Ser Asn Gly  Lys Phe Gly Gly Leu  Gln Asn Lys 
    1865                 1870                 1875             


Ala Pro  Pro Met Asp Lys Leu  Arg Gly Met Val Phe  Gly Ala Pro 
    1880                 1885                 1890             


Val Pro  Lys Gln Cys Leu Ile  Leu Gly Glu Gln Ile  Asp Leu Leu 
    1895                 1900                 1905             


Gln Gln  Tyr Arg Ser Ala Val  Cys Lys Leu Asp Ser  Val Asn Lys 
    1910                 1915                 1920             


Asp Leu  Asn Ser Gln Leu Glu  Tyr Leu Arg Thr Pro  Asp Met Arg 
    1925                 1930                 1935             


Lys Lys  Lys Gln Glu Leu Asp  Glu His Glu Lys Asn  Leu Lys Leu 
    1940                 1945                 1950             


Ile Glu  Glu Lys Leu Gly Met  Thr Pro Ile Arg Lys  Cys Asn Asp 
    1955                 1960                 1965             


Ser Leu  Arg His Ser Pro Lys  Val Glu Thr Thr Asp  Cys Pro Val 
    1970                 1975                 1980             


Pro Pro  Lys Arg Met Arg Arg  Glu Ala Thr Arg Gln  Asn Arg Ile 
    1985                 1990                 1995             


Ile Thr  Lys Thr Asp Val 
    2000                 


<210>  8
<211>  2005
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr 
1               5                   10                  15      


Glu Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp 
            20                  25                  30          


Arg Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly 
        35                  40                  45              


Glu Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu 
    50                  55                  60                  


Gly Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys 
65                  70                  75                  80  


Glu Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr 
                85                  90                  95      


Leu Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys 
            100                 105                 110         


Glu Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly 
        115                 120                 125             


Met Tyr Glu Tyr Tyr Ala Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala 
    130                 135                 140                 


Leu Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile 
145                 150                 155                 160 


Gly Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly 
                165                 170                 175     


Lys Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys 
            180                 185                 190         


Gln Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln 
        195                 200                 205             


Gly Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val 
    210                 215                 220                 


Pro Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys 
225                 230                 235                 240 


Gln Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro 
                245                 250                 255     


Ala Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe 
            260                 265                 270         


Glu Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg 
        275                 280                 285             


Asn Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Phe Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr 
305                 310                 315                 320 


Ala Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys 
                325                 330                 335     


Asn Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr 
            340                 345                 350         


Tyr Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val 
        355                 360                 365             


Glu Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly 
    370                 375                 380                 


Lys Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln 
385                 390                 395                 400 


Thr Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His 
                405                 410                 415     


Val Glu Gly Val Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe 
            420                 425                 430         


Leu Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys 
        435                 440                 445             


Leu Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala 
    450                 455                 460                 


Ala Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu 
465                 470                 475                 480 


Ile Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys 
                485                 490                 495     


Lys Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala 
            500                 505                 510         


Leu Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe 
        515                 520                 525             


Met Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg 
    530                 535                 540                 


Ile Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala 
545                 550                 555                 560 


Leu Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe 
                565                 570                 575     


Thr Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys 
            580                 585                 590         


Gln Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile 
        595                 600                 605             


Tyr Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe 
    610                 615                 620                 


Tyr Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu 
625                 630                 635                 640 


Val Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala 
                645                 650                 655     


Leu Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr 
            660                 665                 670         


Val Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg 
        675                 680                 685             


Leu Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu 
    690                 695                 700                 


Pro Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile 
705                 710                 715                 720 


Glu Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr 
                725                 730                 735     


Ser His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu 
            740                 745                 750         


His Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His 
        755                 760                 765             


Gly Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys 
    770                 775                 780                 


Leu Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn 
785                 790                 795                 800 


Ala Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe 
                805                 810                 815     


Ser Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp 
            820                 825                 830         


Leu Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln 
        835                 840                 845             


Asp Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val 
    850                 855                 860                 


Leu Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly 
865                 870                 875                 880 


Pro Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser 
                885                 890                 895     


Cys Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys 
            900                 905                 910         


Glu Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg 
        915                 920                 925             


Arg Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly 
    930                 935                 940                 


Thr Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile 
945                 950                 955                 960 


Thr Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro 
                965                 970                 975     


Asn Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile 
            980                 985                 990         


Leu Thr Gly Ser Ala Ile Gln Val  Gln Asn Ile Lys Lys  Asp Gln Thr 
        995                 1000                 1005             


Leu Lys  Ala Arg Ile Glu Ile  Pro Ser Cys Lys Asp  Val Ala Pro 
    1010                 1015                 1020             


Val Glu  Lys Thr Ile Lys Leu  Leu Pro Ser Ser His  Val Ala Arg 
    1025                 1030                 1035             


Leu Gln  Ile Phe Ser Val Glu  Gly Gln Lys Ala Ile  Gln Ile Lys 
    1040                 1045                 1050             


His Gln  Asp Glu Val Asn Trp  Ile Ala Gly Asp Ile  Met His Asn 
    1055                 1060                 1065             


Leu Ile  Phe Gln Met Tyr Asp  Glu Gly Glu Arg Glu  Ile Asn Ile 
    1070                 1075                 1080             


Thr Ser  Ala Leu Ala Glu Lys  Ile Lys Val Asn Trp  Thr Pro Glu 
    1085                 1090                 1095             


Ile Asn  Lys Glu His Leu Leu  Gln Gly Leu Leu Pro  Asp Val Gln 
    1100                 1105                 1110             


Val Pro  Thr Ser Val Lys Asp  Met Arg Tyr Cys Gln  Val Ser Phe 
    1115                 1120                 1125             


Gln Asp  Asp His Val Ser Leu  Glu Ser Ala Phe Thr  Val Arg Pro 
    1130                 1135                 1140             


Leu Pro  Asp Glu Pro Lys His  Leu Lys Cys Glu Met  Lys Gly Gly 
    1145                 1150                 1155             


Lys Thr  Val Gln Met Gly Gln  Glu Leu Gln Gly Glu  Val Val Ile 
    1160                 1165                 1170             


Ile Ile  Thr Asp Gln Tyr Gly  Asn Gln Ile Gln Ala  Phe Ser Pro 
    1175                 1180                 1185             


Ser Ser  Leu Ser Ser Leu Ser  Ile Ala Gly Val Gly  Leu Asp Ser 
    1190                 1195                 1200             


Ser Asn  Leu Lys Thr Thr Phe  Gln Glu Asn Thr Gln  Ser Ile Ser 
    1205                 1210                 1215             


Val Arg  Gly Ile Lys Phe Ile  Pro Gly Pro Pro Gly  Asn Lys Asp 
    1220                 1225                 1230             


Leu Cys  Phe Thr Trp Arg Glu  Phe Ser Asp Phe Ile  Arg Val Gln 
    1235                 1240                 1245             


Leu Ile  Ser Gly Pro Pro Ala  Lys Leu Leu Leu Ile  Asp Trp Pro 
    1250                 1255                 1260             


Glu Leu  Lys Glu Ser Ile Pro  Val Ile Asn Gly Arg  Asp Leu Gln 
    1265                 1270                 1275             


Asn Pro  Ile Ile Val Gln Leu  Cys Asp Gln Trp Asp  Asn Pro Ala 
    1280                 1285                 1290             


Pro Val  Gln His Val Lys Ile  Ser Leu Thr Lys Ala  Ser Asn Leu 
    1295                 1300                 1305             


Lys Leu  Met Pro Ser Asn Gln  Gln His Lys Thr Asp  Glu Lys Gly 
    1310                 1315                 1320             


Arg Ala  Asn Leu Gly Val Phe  Ser Val Phe Ala Pro  Arg Gly Glu 
    1325                 1330                 1335             


His Thr  Leu Gln Val Lys Ala  Ile Tyr Asn Lys Ser  Ile Ile Glu 
    1340                 1345                 1350             


Gly Pro  Ile Ile Lys Leu Met  Ile Leu Pro Asp Pro  Glu Lys Pro 
    1355                 1360                 1365             


Val Arg  Leu Asn Val Lys Tyr  Asp Lys Asp Ala Ser  Phe Leu Ala 
    1370                 1375                 1380             


Gly Gly  Leu Phe Thr Asp Phe  Met Ile Ser Val Ile  Ser Glu Asp 
    1385                 1390                 1395             


Asp Ser  Ile Ile Lys Asn Ile  Asn Pro Ala Arg Ile  Ser Met Lys 
    1400                 1405                 1410             


Met Trp  Lys Leu Ser Thr Ser  Gly Asn Arg Pro Pro  Ala Asn Ala 
    1415                 1420                 1425             


Glu Thr  Phe Ser Cys Asn Lys  Ile Lys Asp Asn Asp  Lys Glu Asp 
    1430                 1435                 1440             


Gly Cys  Phe Tyr Phe Arg Asp  Lys Val Ile Pro Asn  Lys Val Gly 
    1445                 1450                 1455             


Thr Tyr  Cys Ile Gln Phe Gly  Phe Met Met Asp Lys  Thr Asn Ile 
    1460                 1465                 1470             


Leu Asn  Ser Glu Gln Val Ile  Val Glu Val Leu Pro  Asn Gln Pro 
    1475                 1480                 1485             


Val Lys  Leu Val Pro Lys Ile  Lys Pro Pro Thr Pro  Ala Val Ser 
    1490                 1495                 1500             


Asn Val  Arg Ser Val Ala Ser  Arg Thr Leu Val Arg  Asp Leu His 
    1505                 1510                 1515             


Leu Ser  Ile Thr Asp Asp Tyr  Asp Asn His Thr Gly  Ile Asp Leu 
    1520                 1525                 1530             


Val Gly  Thr Ile Ile Ala Thr  Ile Lys Gly Ser Asn  Glu Glu Asp 
    1535                 1540                 1545             


Thr Asp  Thr Pro Leu Phe Ile  Gly Lys Val Arg Thr  Leu Glu Phe 
    1550                 1555                 1560             


Pro Phe  Val Asn Gly Ser Ala  Glu Ile Met Ser Leu  Val Leu Ala 
    1565                 1570                 1575             


Glu Ser  Ser Pro Gly Arg Asp  Ser Thr Glu Tyr Phe  Ile Val Phe 
    1580                 1585                 1590             


Glu Pro  Arg Leu Pro Leu Leu  Ser Arg Thr Leu Glu  Pro Tyr Ile 
    1595                 1600                 1605             


Leu Pro  Phe Met Phe Tyr Asn  Asp Val Lys Lys Gln  Gln Gln Met 
    1610                 1615                 1620             


Ala Ala  Leu Thr Lys Glu Lys  Asp Gln Leu Ser Gln  Ser Ile Val 
    1625                 1630                 1635             


Met Tyr  Lys Ser Leu Phe Glu  Ala Ser Gln Gln Leu  Leu Asn Glu 
    1640                 1645                 1650             


Met Lys  Cys Gln Val Glu Glu  Ala Arg Leu Lys Glu  Ala Gln Leu 
    1655                 1660                 1665             


Arg Asn  Glu Leu Lys Ile His  Asn Ile Asp Ile Pro  Thr Thr Gln 
    1670                 1675                 1680             


Gln Val  Pro His Ile Glu Ala  Leu Leu Lys Arg Lys  Leu Ser Glu 
    1685                 1690                 1695             


Gln Glu  Glu Leu Lys Lys Lys  Pro Arg Arg Ser Cys  Thr Leu Pro 
    1700                 1705                 1710             


Asn Tyr  Thr Lys Gly Ser Gly  Asp Val Leu Gly Lys  Ile Ala His 
    1715                 1720                 1725             


Leu Ala  Gln Ile Glu Asp Asp  Arg Ala Ala Met Val  Ile Ser Trp 
    1730                 1735                 1740             


His Leu  Ala Ser Asp Met Asp  Cys Val Val Thr Leu  Thr Thr Asp 
    1745                 1750                 1755             


Ala Ala  Arg Arg Ile Tyr Asp  Glu Thr Gln Gly Arg  Gln Gln Val 
    1760                 1765                 1770             


Leu Pro  Leu Asp Ser Ile Tyr  Lys Lys Thr Leu Pro  Asp Trp Lys 
    1775                 1780                 1785             


Arg Ser  Leu Pro His Phe Arg  Asn Gly Lys Leu Tyr  Phe Lys Pro 
    1790                 1795                 1800             


Ile Gly  Asp Pro Val Phe Ala  Arg Asp Leu Leu Thr  Phe Pro Asp 
    1805                 1810                 1815             


Asn Val  Glu His Cys Glu Thr  Val Phe Gly Met Leu  Leu Gly Asp 
    1820                 1825                 1830             


Thr Ile  Ile Leu Asp Asn Leu  Asp Ala Ala Asn His  Tyr Arg Lys 
    1835                 1840                 1845             


Glu Val  Val Lys Ile Thr His  Cys Pro Thr Leu Leu  Thr Arg Asp 
    1850                 1855                 1860             


Gly Asp  Arg Ile Arg Ser Asn  Gly Lys Phe Gly Gly  Leu Gln Asn 
    1865                 1870                 1875             


Lys Ala  Pro Pro Met Asp Lys  Leu Arg Gly Met Val  Phe Gly Ala 
    1880                 1885                 1890             


Pro Val  Pro Lys Gln Cys Leu  Ile Leu Gly Glu Gln  Ile Asp Leu 
    1895                 1900                 1905             


Leu Gln  Gln Tyr Arg Ser Ala  Val Cys Lys Leu Asp  Ser Val Asn 
    1910                 1915                 1920             


Lys Asp  Leu Asn Ser Gln Leu  Glu Tyr Leu Arg Thr  Pro Asp Met 
    1925                 1930                 1935             


Arg Lys  Lys Lys Gln Glu Leu  Asp Glu His Glu Lys  Asn Leu Lys 
    1940                 1945                 1950             


Leu Ile  Glu Glu Lys Leu Gly  Met Thr Pro Ile Arg  Lys Cys Asn 
    1955                 1960                 1965             


Asp Ser  Leu Arg His Ser Pro  Lys Val Glu Thr Thr  Asp Cys Pro 
    1970                 1975                 1980             


Val Pro  Pro Lys Arg Met Arg  Arg Glu Ala Thr Arg  Gln Asn Arg 
    1985                 1990                 1995             


Ile Ile  Thr Lys Thr Asp Val  
    2000                 2005 


<210>  9
<211>  2004
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr Glu 
1               5                   10                  15      


Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp Arg 
            20                  25                  30          


Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly Glu 
        35                  40                  45              


Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu Gly 
    50                  55                  60                  


Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys Glu 
65                  70                  75                  80  


Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr Leu 
                85                  90                  95      


Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys Glu 
            100                 105                 110         


Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly Met 
        115                 120                 125             


Tyr Glu Tyr Tyr Ala Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala Leu 
    130                 135                 140                 


Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile Gly 
145                 150                 155                 160 


Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly Lys 
                165                 170                 175     


Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys Gln 
            180                 185                 190         


Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln Gly 
        195                 200                 205             


Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val Pro 
    210                 215                 220                 


Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys Gln 
225                 230                 235                 240 


Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro Ala 
                245                 250                 255     


Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe Glu 
            260                 265                 270         


Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg Asn 
        275                 280                 285             


Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg Phe 
    290                 295                 300                 


Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr Ala 
305                 310                 315                 320 


Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys Asn 
                325                 330                 335     


Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr Tyr 
            340                 345                 350         


Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val Glu 
        355                 360                 365             


Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly Lys 
    370                 375                 380                 


Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln Thr 
385                 390                 395                 400 


Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His Val 
                405                 410                 415     


Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe Leu 
            420                 425                 430         


Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys Leu 
        435                 440                 445             


Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala Ala 
    450                 455                 460                 


Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu Ile 
465                 470                 475                 480 


Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys Lys 
                485                 490                 495     


Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala Leu 
            500                 505                 510         


Phe Thr Asn Asp Glu Phe Gln Val Ser Thr Asn Lys Leu Thr Phe Met 
        515                 520                 525             


Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg Ile 
    530                 535                 540                 


Leu Asn Gly Gln Glu Gln Arg Met Lys Ile Asp Arg Glu Phe Ala Leu 
545                 550                 555                 560 


Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe Thr 
                565                 570                 575     


Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys Gln 
            580                 585                 590         


Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile Tyr 
        595                 600                 605             


Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe Tyr 
    610                 615                 620                 


Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu Val 
625                 630                 635                 640 


Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala Leu 
                645                 650                 655     


Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr Val 
            660                 665                 670         


Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg Leu 
        675                 680                 685             


Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu Pro 
    690                 695                 700                 


Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile Glu 
705                 710                 715                 720 


Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr Ser 
                725                 730                 735     


His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu His 
            740                 745                 750         


Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His Gly 
        755                 760                 765             


Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys Leu 
    770                 775                 780                 


Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn Ala 
785                 790                 795                 800 


Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe Ser 
                805                 810                 815     


Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp Leu 
            820                 825                 830         


Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln Asp 
        835                 840                 845             


Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val Leu 
    850                 855                 860                 


Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly Pro 
865                 870                 875                 880 


Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser Cys 
                885                 890                 895     


Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys Glu 
            900                 905                 910         


Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg Arg 
        915                 920                 925             


Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly Thr 
    930                 935                 940                 


Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile Thr 
945                 950                 955                 960 


Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro Asn 
                965                 970                 975     


Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile Leu 
            980                 985                 990         


Thr Gly Ser Ala Ile Gln Val Gln  Asn Ile Lys Lys Asp  Gln Thr Leu 
        995                 1000                 1005             


Lys Ala  Arg Ile Glu Ile Pro  Ser Cys Lys Asp Val  Ala Pro Val 
    1010                 1015                 1020             


Glu Lys  Thr Ile Lys Leu Leu  Pro Ser Ser His Val  Ala Arg Leu 
    1025                 1030                 1035             


Gln Ile  Phe Ser Val Glu Gly  Gln Lys Ala Ile Gln  Ile Lys His 
    1040                 1045                 1050             


Gln Asp  Glu Val Asn Trp Ile  Ala Gly Asp Ile Met  His Asn Leu 
    1055                 1060                 1065             


Ile Phe  Gln Met Tyr Asp Glu  Gly Glu Arg Glu Ile  Asn Ile Thr 
    1070                 1075                 1080             


Ser Ala  Leu Ala Glu Lys Ile  Lys Val Asn Trp Thr  Pro Glu Ile 
    1085                 1090                 1095             


Asn Lys  Glu His Leu Leu Gln  Gly Leu Leu Pro Asp  Val Gln Val 
    1100                 1105                 1110             


Pro Thr  Ser Val Lys Asp Met  Arg Tyr Cys Gln Val  Ser Phe Gln 
    1115                 1120                 1125             


Asp Asp  His Val Ser Leu Glu  Ser Ala Phe Thr Val  Arg Pro Leu 
    1130                 1135                 1140             


Pro Asp  Glu Pro Lys His Leu  Lys Cys Glu Met Lys  Gly Gly Lys 
    1145                 1150                 1155             


Thr Val  Gln Met Gly Gln Glu  Leu Gln Gly Glu Val  Val Ile Ile 
    1160                 1165                 1170             


Ile Thr  Asp Gln Tyr Gly Asn  Gln Ile Gln Ala Phe  Ser Pro Ser 
    1175                 1180                 1185             


Ser Leu  Ser Ser Leu Ser Ile  Ala Gly Val Gly Leu  Asp Ser Ser 
    1190                 1195                 1200             


Asn Leu  Lys Thr Thr Phe Gln  Glu Asn Thr Gln Ser  Ile Ser Val 
    1205                 1210                 1215             


Arg Gly  Ile Lys Phe Ile Pro  Gly Pro Pro Gly Asn  Lys Asp Leu 
    1220                 1225                 1230             


Cys Phe  Thr Trp Arg Glu Phe  Ser Asp Phe Ile Arg  Val Gln Leu 
    1235                 1240                 1245             


Ile Ser  Gly Pro Pro Ala Lys  Leu Leu Leu Ile Asp  Trp Pro Glu 
    1250                 1255                 1260             


Leu Lys  Glu Ser Ile Pro Val  Ile Asn Gly Arg Asp  Leu Gln Asn 
    1265                 1270                 1275             


Pro Ile  Ile Val Gln Leu Cys  Asp Gln Trp Asp Asn  Pro Ala Pro 
    1280                 1285                 1290             


Val Gln  His Val Lys Ile Ser  Leu Thr Lys Ala Ser  Asn Leu Lys 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Gln Gln  His Lys Thr Asp Glu  Lys Gly Arg 
    1310                 1315                 1320             


Ala Asn  Leu Gly Val Phe Ser  Val Phe Ala Pro Arg  Gly Glu His 
    1325                 1330                 1335             


Thr Leu  Gln Val Lys Ala Ile  Tyr Asn Lys Ser Ile  Ile Glu Gly 
    1340                 1345                 1350             


Pro Ile  Ile Lys Leu Met Ile  Leu Pro Asp Pro Glu  Lys Pro Val 
    1355                 1360                 1365             


Arg Leu  Asn Val Lys Tyr Asp  Lys Asp Ala Ser Phe  Leu Ala Gly 
    1370                 1375                 1380             


Gly Leu  Phe Thr Asp Phe Met  Ile Ser Val Ile Ser  Glu Asp Asp 
    1385                 1390                 1395             


Ser Ile  Ile Lys Asn Ile Asn  Pro Ala Arg Ile Ser  Met Lys Met 
    1400                 1405                 1410             


Trp Lys  Leu Ser Thr Ser Gly  Asn Arg Pro Pro Ala  Asn Ala Glu 
    1415                 1420                 1425             


Thr Phe  Ser Cys Asn Lys Ile  Lys Asp Asn Asp Lys  Glu Asp Gly 
    1430                 1435                 1440             


Cys Phe  Tyr Phe Arg Asp Lys  Val Ile Pro Asn Lys  Val Gly Thr 
    1445                 1450                 1455             


Tyr Cys  Ile Gln Phe Gly Phe  Met Met Asp Lys Thr  Asn Ile Leu 
    1460                 1465                 1470             


Asn Ser  Glu Gln Val Ile Val  Glu Val Leu Pro Asn  Gln Pro Val 
    1475                 1480                 1485             


Lys Leu  Val Pro Lys Ile Lys  Pro Pro Thr Pro Ala  Val Ser Asn 
    1490                 1495                 1500             


Val Arg  Ser Val Ala Ser Arg  Thr Leu Val Arg Asp  Leu His Leu 
    1505                 1510                 1515             


Ser Ile  Thr Asp Asp Tyr Asp  Asn His Thr Gly Ile  Asp Leu Val 
    1520                 1525                 1530             


Gly Thr  Ile Ile Ala Thr Ile  Lys Gly Ser Asn Glu  Glu Asp Thr 
    1535                 1540                 1545             


Asp Thr  Pro Leu Phe Ile Gly  Lys Val Arg Thr Leu  Glu Phe Pro 
    1550                 1555                 1560             


Phe Val  Asn Gly Ser Ala Glu  Ile Met Ser Leu Val  Leu Ala Glu 
    1565                 1570                 1575             


Ser Ser  Pro Gly Arg Asp Ser  Thr Glu Tyr Phe Ile  Val Phe Glu 
    1580                 1585                 1590             


Pro Arg  Leu Pro Leu Leu Ser  Arg Thr Leu Glu Pro  Tyr Ile Leu 
    1595                 1600                 1605             


Pro Phe  Met Phe Tyr Asn Asp  Val Lys Lys Gln Gln  Gln Met Ala 
    1610                 1615                 1620             


Ala Leu  Thr Lys Glu Lys Asp  Gln Leu Ser Gln Ser  Ile Val Met 
    1625                 1630                 1635             


Tyr Lys  Ser Leu Phe Glu Ala  Ser Gln Gln Leu Leu  Asn Glu Met 
    1640                 1645                 1650             


Lys Cys  Gln Val Glu Glu Ala  Arg Leu Lys Glu Ala  Gln Leu Arg 
    1655                 1660                 1665             


Asn Glu  Leu Lys Ile His Asn  Ile Asp Ile Pro Thr  Thr Gln Gln 
    1670                 1675                 1680             


Val Pro  His Ile Glu Ala Leu  Leu Lys Arg Lys Leu  Ser Glu Gln 
    1685                 1690                 1695             


Glu Glu  Leu Lys Lys Lys Pro  Arg Arg Ser Cys Thr  Leu Pro Asn 
    1700                 1705                 1710             


Tyr Thr  Lys Gly Ser Gly Asp  Val Leu Gly Lys Ile  Ala His Leu 
    1715                 1720                 1725             


Ala Gln  Ile Glu Asp Asp Arg  Ala Ala Met Val Ile  Ser Trp His 
    1730                 1735                 1740             


Leu Ala  Ser Asp Met Asp Cys  Val Val Thr Leu Thr  Thr Asp Ala 
    1745                 1750                 1755             


Ala Arg  Arg Ile Tyr Asp Glu  Thr Gln Gly Arg Gln  Gln Val Leu 
    1760                 1765                 1770             


Pro Leu  Asp Ser Ile Tyr Lys  Lys Thr Leu Pro Asp  Trp Lys Arg 
    1775                 1780                 1785             


Ser Leu  Pro His Phe Arg Asn  Gly Lys Leu Tyr Phe  Lys Pro Ile 
    1790                 1795                 1800             


Gly Asp  Pro Val Phe Ala Arg  Asp Leu Leu Thr Phe  Pro Asp Asn 
    1805                 1810                 1815             


Val Glu  His Cys Glu Thr Val  Phe Gly Met Leu Leu  Gly Asp Thr 
    1820                 1825                 1830             


Ile Ile  Leu Asp Asn Leu Asp  Ala Ala Asn His Tyr  Arg Lys Glu 
    1835                 1840                 1845             


Val Val  Lys Ile Thr His Cys  Pro Thr Leu Leu Thr  Arg Asp Gly 
    1850                 1855                 1860             


Asp Arg  Ile Arg Ser Asn Gly  Lys Phe Gly Gly Leu  Gln Asn Lys 
    1865                 1870                 1875             


Ala Pro  Pro Met Asp Lys Leu  Arg Gly Met Val Phe  Gly Ala Pro 
    1880                 1885                 1890             


Val Pro  Lys Gln Cys Leu Ile  Leu Gly Glu Gln Ile  Asp Leu Leu 
    1895                 1900                 1905             


Gln Gln  Tyr Arg Ser Ala Val  Cys Lys Leu Asp Ser  Val Asn Lys 
    1910                 1915                 1920             


Asp Leu  Asn Ser Gln Leu Glu  Tyr Leu Arg Thr Pro  Asp Met Arg 
    1925                 1930                 1935             


Lys Lys  Lys Gln Glu Leu Asp  Glu His Glu Lys Asn  Leu Lys Leu 
    1940                 1945                 1950             


Ile Glu  Glu Lys Leu Gly Met  Thr Pro Ile Arg Lys  Cys Asn Asp 
    1955                 1960                 1965             


Ser Leu  Arg His Ser Pro Lys  Val Glu Thr Thr Asp  Cys Pro Val 
    1970                 1975                 1980             


Pro Pro  Lys Arg Met Arg Arg  Glu Ala Thr Arg Gln  Asn Arg Ile 
    1985                 1990                 1995             


Ile Thr  Lys Thr Asp Val 
    2000                 


<210>  10
<211>  2004
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ala Ala Asp Gly Gly Gly Pro Gly Gly Ala Ser Val Gly Thr Glu 
1               5                   10                  15      


Glu Asp Gly Gly Gly Val Gly His Arg Thr Val Tyr Leu Phe Asp Arg 
            20                  25                  30          


Arg Glu Lys Glu Ser Glu Leu Gly Asp Arg Pro Leu Gln Val Gly Glu 
        35                  40                  45              


Arg Ser Asp Tyr Ala Gly Phe Arg Ala Cys Val Cys Gln Thr Leu Gly 
    50                  55                  60                  


Ile Ser Pro Glu Glu Lys Phe Val Ile Thr Thr Thr Ser Arg Lys Glu 
65                  70                  75                  80  


Ile Thr Cys Asp Asn Phe Asp Glu Thr Val Lys Asp Gly Val Thr Leu 
                85                  90                  95      


Tyr Leu Leu Gln Ser Val Asn Gln Leu Leu Leu Thr Ala Thr Lys Glu 
            100                 105                 110         


Arg Ile Asp Phe Leu Pro His Tyr Asp Thr Leu Val Lys Ser Gly Met 
        115                 120                 125             


Tyr Glu Tyr Tyr Ala Ser Glu Gly Gln Asn Pro Leu Pro Phe Ala Leu 
    130                 135                 140                 


Ala Glu Leu Ile Asp Asn Ser Leu Ser Ala Thr Ser Arg Asn Ile Gly 
145                 150                 155                 160 


Val Arg Arg Ile Gln Ile Lys Leu Leu Phe Asp Glu Thr Gln Gly Lys 
                165                 170                 175     


Pro Ala Val Ala Val Ile Asp Asn Gly Arg Gly Met Thr Ser Lys Gln 
            180                 185                 190         


Leu Asn Asn Trp Ala Val Tyr Arg Leu Ser Lys Phe Thr Arg Gln Gly 
        195                 200                 205             


Asp Phe Glu Ser Asp His Ser Gly Tyr Val Arg Pro Val Pro Val Pro 
    210                 215                 220                 


Arg Ser Leu Asn Ser Asp Ile Ser Tyr Phe Gly Val Gly Gly Lys Gln 
225                 230                 235                 240 


Ala Val Phe Phe Val Gly Gln Ser Ala Arg Met Ile Ser Lys Pro Ala 
                245                 250                 255     


Asp Ser Gln Asp Val His Glu Leu Val Leu Ser Lys Glu Asp Phe Glu 
            260                 265                 270         


Lys Lys Glu Lys Asn Lys Glu Ala Ile Tyr Ser Gly Tyr Ile Arg Asn 
        275                 280                 285             


Arg Lys Pro Ser Asp Ser Val His Ile Thr Asn Asp Asp Glu Arg Phe 
    290                 295                 300                 


Leu His His Leu Ile Ile Glu Glu Lys Glu Lys Asp Ser Phe Thr Ala 
305                 310                 315                 320 


Val Val Ile Thr Gly Val Gln Pro Glu His Ile Gln Tyr Leu Lys Asn 
                325                 330                 335     


Tyr Phe His Leu Trp Thr Arg Gln Leu Ala His Ile Tyr His Tyr Tyr 
            340                 345                 350         


Ile His Gly Pro Lys Gly Asn Glu Ile Arg Thr Ser Lys Glu Val Glu 
        355                 360                 365             


Pro Phe Asn Asn Ile Asp Ile Glu Ile Ser Met Phe Glu Lys Gly Lys 
    370                 375                 380                 


Val Pro Lys Ile Val Asn Leu Arg Glu Ile Gln Asp Asp Met Gln Thr 
385                 390                 395                 400 


Leu Tyr Val Asn Thr Ala Ala Asp Ser Phe Glu Phe Lys Ala His Val 
                405                 410                 415     


Glu Gly Asp Gly Val Val Glu Gly Ile Ile Arg Tyr His Pro Phe Leu 
            420                 425                 430         


Tyr Asp Arg Glu Thr Tyr Pro Asp Asp Pro Cys Phe Pro Ser Lys Leu 
        435                 440                 445             


Lys Asp Glu Asp Asp Glu Asp Asp Cys Phe Ile Leu Glu Lys Ala Ala 
    450                 455                 460                 


Arg Gly Lys Arg Pro Ile Phe Glu Cys Phe Trp Asn Gly Arg Leu Ile 
465                 470                 475                 480 


Pro Tyr Thr Ser Val Glu Asp Phe Asp Trp Cys Thr Pro Pro Lys Lys 
                485                 490                 495     


Arg Gly Leu Ala Pro Ile Glu Cys Tyr Asn Arg Ile Ser Gly Ala Leu 
            500                 505                 510         


Phe Thr Asn Asp Lys Phe Gln Val Ser Thr Asn Lys Leu Thr Phe Met 
        515                 520                 525             


Asp Leu Glu Leu Lys Leu Lys Asp Lys Asn Thr Leu Phe Thr Arg Ile 
    530                 535                 540                 


Leu Asn Gly Gln Glu Gln Gln Met Lys Ile Asp Arg Glu Phe Ala Leu 
545                 550                 555                 560 


Trp Leu Lys Asp Cys His Glu Lys Tyr Asp Lys Gln Ile Lys Phe Thr 
                565                 570                 575     


Leu Phe Lys Gly Val Ile Thr Arg Pro Asp Leu Pro Ser Lys Lys Gln 
            580                 585                 590         


Gly Pro Trp Ala Thr Tyr Ala Ala Ile Glu Trp Asp Gly Lys Ile Tyr 
        595                 600                 605             


Lys Ala Gly Gln Leu Val Lys Thr Ile Lys Thr Leu Pro Leu Phe Tyr 
    610                 615                 620                 


Gly Ser Ile Val Arg Phe Phe Leu Tyr Gly Asp His Asp Gly Glu Val 
625                 630                 635                 640 


Tyr Ala Thr Gly Gly Glu Val Gln Ile Ala Met Glu Pro Gln Ala Leu 
                645                 650                 655     


Tyr Asp Glu Val Arg Thr Val Pro Ile Ala Lys Leu Asp Arg Thr Val 
            660                 665                 670         


Ala Glu Lys Ala Val Lys Lys Tyr Val Glu Asp Glu Met Ala Arg Leu 
        675                 680                 685             


Pro Asp Arg Leu Ser Val Thr Trp Pro Glu Gly Asp Glu Leu Leu Pro 
    690                 695                 700                 


Asn Glu Val Arg Pro Ala Gly Thr Pro Ile Gly Ala Leu Arg Ile Glu 
705                 710                 715                 720 


Ile Leu Asn Lys Lys Gly Glu Ala Met Gln Lys Leu Pro Gly Thr Ser 
                725                 730                 735     


His Gly Gly Ser Lys Lys Leu Leu Val Glu Leu Lys Val Ile Leu His 
            740                 745                 750         


Ser Ser Ser Gly Asn Lys Glu Ile Ile Ser His Ile Ser Gln His Gly 
        755                 760                 765             


Gly Lys Trp Pro Tyr Trp Phe Lys Lys Met Glu Asn Ile Gln Lys Leu 
    770                 775                 780                 


Gly Asn Tyr Thr Leu Lys Leu Gln Val Val Leu Asn Glu Ser Asn Ala 
785                 790                 795                 800 


Asp Thr Tyr Ala Gly Arg Pro Leu Pro Ser Lys Ala Ile Lys Phe Ser 
                805                 810                 815     


Val Lys Glu Gly Lys Pro Glu Lys Phe Ser Phe Gly Leu Leu Asp Leu 
            820                 825                 830         


Pro Phe Arg Val Gly Val Pro Phe Asn Ile Pro Leu Glu Phe Gln Asp 
        835                 840                 845             


Glu Phe Gly His Thr Ser Gln Leu Val Thr Asp Ile Gln Pro Val Leu 
    850                 855                 860                 


Glu Ala Ser Gly Leu Ser Leu His Tyr Glu Glu Ile Thr Lys Gly Pro 
865                 870                 875                 880 


Asn Cys Val Ile Arg Gly Val Thr Ala Lys Gly Pro Val Asn Ser Cys 
                885                 890                 895     


Gln Gly Lys Asn Tyr Asn Leu Lys Val Thr Leu Pro Gly Leu Lys Glu 
            900                 905                 910         


Asp Ser Gln Ile Leu Lys Ile Arg Leu Leu Pro Gly His Pro Arg Arg 
        915                 920                 925             


Leu Lys Val Lys Pro Asp Ser Glu Ile Leu Val Ile Glu Asn Gly Thr 
    930                 935                 940                 


Ala Phe Pro Phe Gln Val Glu Val Leu Asp Glu Ser Asp Asn Ile Thr 
945                 950                 955                 960 


Ala Gln Pro Lys Leu Ile Val His Cys Lys Phe Ser Gly Ala Pro Asn 
                965                 970                 975     


Leu Pro Val Tyr Val Val Asp Cys Ser Ser Ser Gly Thr Ser Ile Leu 
            980                 985                 990         


Thr Gly Ser Ala Ile Gln Val Gln  Asn Ile Lys Lys Asp  Gln Thr Leu 
        995                 1000                 1005             


Lys Ala  Arg Ile Glu Ile Pro  Ser Cys Lys Asp Val  Ala Pro Val 
    1010                 1015                 1020             


Glu Lys  Thr Ile Lys Leu Leu  Pro Ser Ser His Val  Ala Arg Leu 
    1025                 1030                 1035             


Gln Ile  Phe Ser Val Glu Gly  Gln Lys Ala Ile Gln  Ile Lys His 
    1040                 1045                 1050             


Gln Asp  Glu Val Asn Trp Ile  Ala Gly Asp Ile Met  His Asn Leu 
    1055                 1060                 1065             


Ile Phe  Gln Met Tyr Asp Glu  Gly Glu Arg Glu Ile  Asn Ile Thr 
    1070                 1075                 1080             


Ser Ala  Leu Ala Glu Lys Ile  Lys Val Asn Trp Thr  Pro Glu Ile 
    1085                 1090                 1095             


Asn Lys  Glu His Leu Leu Gln  Gly Leu Leu Pro Asp  Val Gln Val 
    1100                 1105                 1110             


Pro Thr  Ser Val Lys Asp Met  Arg Tyr Cys Gln Val  Ser Phe Gln 
    1115                 1120                 1125             


Asp Asp  His Val Ser Leu Glu  Ser Ala Phe Thr Val  Arg Pro Leu 
    1130                 1135                 1140             


Pro Asp  Glu Pro Lys His Leu  Lys Cys Glu Met Lys  Gly Gly Lys 
    1145                 1150                 1155             


Thr Val  Gln Met Gly Gln Glu  Leu Gln Gly Glu Val  Val Ile Ile 
    1160                 1165                 1170             


Ile Thr  Asp Gln Tyr Gly Asn  Gln Ile Gln Ala Phe  Ser Pro Ser 
    1175                 1180                 1185             


Ser Leu  Ser Ser Leu Ser Ile  Ala Gly Val Gly Leu  Asp Ser Ser 
    1190                 1195                 1200             


Asn Leu  Lys Thr Thr Phe Gln  Glu Asn Thr Gln Ser  Ile Ser Val 
    1205                 1210                 1215             


Arg Gly  Ile Lys Phe Ile Pro  Gly Pro Pro Gly Asn  Lys Asp Leu 
    1220                 1225                 1230             


Cys Phe  Thr Trp Arg Glu Phe  Ser Asp Phe Ile Arg  Val Gln Leu 
    1235                 1240                 1245             


Ile Ser  Gly Pro Pro Ala Lys  Leu Leu Leu Ile Asp  Trp Pro Glu 
    1250                 1255                 1260             


Leu Lys  Glu Ser Ile Pro Val  Ile Asn Gly Arg Asp  Leu Gln Asn 
    1265                 1270                 1275             


Pro Ile  Ile Val Gln Leu Cys  Asp Gln Trp Asp Asn  Pro Ala Pro 
    1280                 1285                 1290             


Val Gln  His Val Lys Ile Ser  Leu Thr Lys Ala Ser  Asn Leu Lys 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Gln Gln  His Lys Thr Asp Glu  Lys Gly Arg 
    1310                 1315                 1320             


Ala Asn  Leu Gly Val Phe Ser  Val Phe Ala Pro Arg  Gly Glu His 
    1325                 1330                 1335             


Thr Leu  Gln Val Lys Ala Ile  Tyr Asn Lys Ser Ile  Ile Glu Gly 
    1340                 1345                 1350             


Pro Ile  Ile Lys Leu Met Ile  Leu Pro Asp Pro Glu  Lys Pro Val 
    1355                 1360                 1365             


Arg Leu  Asn Val Lys Tyr Asp  Lys Asp Ala Ser Phe  Leu Ala Gly 
    1370                 1375                 1380             


Gly Leu  Phe Thr Asp Phe Met  Ile Ser Val Ile Ser  Glu Asp Asp 
    1385                 1390                 1395             


Ser Ile  Ile Lys Asn Ile Asn  Pro Ala Arg Ile Ser  Met Lys Met 
    1400                 1405                 1410             


Trp Lys  Leu Ser Thr Ser Gly  Asn Arg Pro Pro Ala  Asn Ala Glu 
    1415                 1420                 1425             


Thr Phe  Ser Cys Asn Lys Ile  Lys Asp Asn Asp Lys  Glu Asp Gly 
    1430                 1435                 1440             


Cys Phe  Tyr Phe Arg Asp Lys  Val Ile Pro Asn Lys  Val Gly Thr 
    1445                 1450                 1455             


Tyr Cys  Ile Gln Phe Gly Phe  Met Met Asp Lys Thr  Asn Ile Leu 
    1460                 1465                 1470             


Asn Ser  Glu Gln Val Ile Val  Glu Val Leu Pro Asn  Gln Pro Val 
    1475                 1480                 1485             


Lys Leu  Val Pro Lys Ile Lys  Pro Pro Thr Pro Ala  Val Ser Asn 
    1490                 1495                 1500             


Val Arg  Ser Val Ala Ser Arg  Thr Leu Val Arg Asp  Leu His Leu 
    1505                 1510                 1515             


Ser Ile  Thr Asp Asp Tyr Asp  Asn His Thr Gly Ile  Asp Leu Val 
    1520                 1525                 1530             


Gly Thr  Ile Ile Ala Thr Ile  Lys Gly Ser Asn Glu  Glu Asp Thr 
    1535                 1540                 1545             


Asp Thr  Pro Leu Phe Ile Gly  Lys Val Arg Thr Leu  Glu Phe Pro 
    1550                 1555                 1560             


Phe Val  Asn Gly Ser Ala Glu  Ile Met Ser Leu Val  Leu Ala Glu 
    1565                 1570                 1575             


Ser Ser  Pro Gly Arg Asp Ser  Thr Glu Tyr Phe Ile  Val Phe Glu 
    1580                 1585                 1590             


Pro Arg  Leu Pro Leu Leu Ser  Arg Thr Leu Glu Pro  Tyr Ile Leu 
    1595                 1600                 1605             


Pro Phe  Met Phe Tyr Asn Asp  Val Lys Lys Gln Gln  Gln Met Ala 
    1610                 1615                 1620             


Ala Leu  Thr Lys Glu Lys Asp  Gln Leu Ser Gln Ser  Ile Val Met 
    1625                 1630                 1635             


Tyr Lys  Ser Leu Phe Glu Ala  Ser Gln Gln Leu Leu  Asn Glu Met 
    1640                 1645                 1650             


Lys Cys  Gln Val Glu Glu Ala  Arg Leu Lys Glu Ala  Gln Leu Arg 
    1655                 1660                 1665             


Asn Glu  Leu Lys Ile His Asn  Ile Asp Ile Pro Thr  Thr Gln Gln 
    1670                 1675                 1680             


Val Pro  His Ile Glu Ala Leu  Leu Lys Arg Lys Leu  Ser Glu Gln 
    1685                 1690                 1695             


Glu Glu  Leu Lys Lys Lys Pro  Arg Arg Ser Cys Thr  Leu Pro Asn 
    1700                 1705                 1710             


Tyr Thr  Lys Gly Ser Gly Asp  Val Leu Gly Lys Ile  Ala His Leu 
    1715                 1720                 1725             


Ala Gln  Ile Glu Asp Asp Arg  Ala Ala Met Val Ile  Ser Trp His 
    1730                 1735                 1740             


Leu Ala  Ser Asp Met Asp Cys  Val Val Thr Leu Thr  Thr Asp Ala 
    1745                 1750                 1755             


Ala Arg  Arg Ile Tyr Asp Glu  Thr Gln Gly Arg Gln  Gln Val Leu 
    1760                 1765                 1770             


Pro Leu  Asp Ser Ile Tyr Lys  Lys Thr Leu Pro Asp  Trp Lys Arg 
    1775                 1780                 1785             


Ser Leu  Pro His Phe Arg Asn  Gly Lys Leu Tyr Phe  Lys Pro Ile 
    1790                 1795                 1800             


Gly Asp  Pro Val Phe Ala Arg  Asp Leu Leu Thr Phe  Pro Asp Asn 
    1805                 1810                 1815             


Val Glu  His Cys Glu Thr Val  Phe Gly Met Leu Leu  Gly Asp Thr 
    1820                 1825                 1830             


Ile Ile  Leu Asp Asn Leu Asp  Ala Ala Asn His Tyr  Arg Lys Glu 
    1835                 1840                 1845             


Val Val  Lys Ile Thr His Cys  Pro Thr Leu Leu Thr  Arg Asp Gly 
    1850                 1855                 1860             


Asp Arg  Ile Arg Ser Asn Gly  Lys Phe Gly Gly Leu  Gln Asn Lys 
    1865                 1870                 1875             


Ala Pro  Pro Met Asp Lys Leu  Arg Gly Met Val Phe  Gly Ala Pro 
    1880                 1885                 1890             


Val Pro  Lys Gln Cys Leu Ile  Leu Gly Glu Gln Ile  Asp Leu Leu 
    1895                 1900                 1905             


Gln Gln  Tyr Arg Ser Ala Val  Cys Lys Leu Asp Ser  Val Asn Lys 
    1910                 1915                 1920             


Asp Leu  Asn Ser Gln Leu Glu  Tyr Leu Arg Thr Pro  Asp Met Arg 
    1925                 1930                 1935             


Lys Lys  Lys Gln Glu Leu Asp  Glu His Glu Lys Asn  Leu Lys Leu 
    1940                 1945                 1950             


Ile Glu  Glu Lys Leu Gly Met  Thr Pro Ile Arg Lys  Cys Asn Asp 
    1955                 1960                 1965             


Ser Leu  Arg His Ser Pro Lys  Val Glu Thr Thr Asp  Cys Pro Val 
    1970                 1975                 1980             


Pro Pro  Lys Arg Met Arg Arg  Glu Ala Thr Arg Gln  Asn Arg Ile 
    1985                 1990                 1995             


Ile Thr  Lys Thr Asp Val 
    2000                 


<210>  11
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  11
gaaggtaggg aggaaaag                                                     18


<210>  12
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  12
actcaaccta aaaatataca atct                                              24


<210>  13
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  13
aaatatgtag ggaagggtgt aagtt                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  14
ggagagaggg tttggtatat ttaag                                             25


<210>  15
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  15
attcatgaag gggtggagcc t                                                 21


<210>  16
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  16
cagagaacgg ctggcccagg ccat                                              24


<210>  17
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  17
cgcggatcca cgaaagaaag aattgacttt ctacctc                                37


<210>  18
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  18
cggaattcat tcatctcctt caggccaagt tacagac                                37


<210>  19
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  19
atgtatgagt attattcgag tgaaggacag aat                                    33


<210>  20
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  20
attctgtcct tcactcgaat aatactcata cat                                    33


<210>  21
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  21
gtatgagtat tatgcgtgtg aaggacagaa tcct                                   34


<210>  22
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  22
aggattctgt ccttcacacg cataatactc atac                                   34


<210>  23
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  23
gagtattatg cgagtggagg acagaatcct ttg                                    33


<210>  24
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  24
caaaggattc tgtcctccac tcgcataata ctc                                    33


<210>  25
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  25
cacgttgaag gagtcggtgt agtggaag                                          28


<210>  26
<211>  28
<212>  DNA
<213>  Homo sapiens

<400>  26
cttccactac accgactcct tcaacgtg                                          28


<210>  27
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  27
catatttatc attactgtat tcatggacca aaag                                   34


<210>  28
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  28
cttttggtcc atgaatacag taatgataaa tatg                                   34


<210>  29
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  29
cagcacaaat aaactgatgt ttatggatct tgagctg                                37


<210>  30
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  30
cagctcaaga tccataaaca tcagtttatt tgtgctg                                37


<210>  31
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  31
cagtgggtgt catggatgct                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  32
tccatggcta gaccacttgc                                                   20


<210>  33
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  33
gcaattattt cccatgaacg a                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  34
atcaacgcga gcttatgacc                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  35
cgaatgcaaa gtccttgggc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  36
gcatccatga cacccactga                                                   20


