                               SEQUENCE LISTING

<110> CRESCENDO BIOLOGICS LTD
 
<120> SINGLE DOMAIN ANTIBODIES TO PROGRAMMED CELL DEATH (PD-1)

<130> P33862WO1

<140>
<141>

<150> GB 1700207.2
<151> 2017-01-06

<150> GB 1700208.0
<151> 2017-01-06

<150> GB 1700210.6
<151> 2017-01-06

<160> 529   

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 4"

<400> 1
Asp His Ala Met His 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 4"

<400> 2
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 3
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 4"

<400> 3
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 4
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.1"

<400> 4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp His 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 5
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 8"

<400> 5
Asp Tyr Ala Met His 
1               5   


<210> 6
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 8"

<400> 6
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 7
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 8"

<400> 7
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 8
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.2"

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 9
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 12"

<400> 9
Asp Tyr Ala Met His 
1               5   


<210> 10
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 12"

<400> 10
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 11
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 12"

<400> 11
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 12
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.3"

<400> 12
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 13
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 16"

<400> 13
Asp Tyr Ala Met His 
1               5   


<210> 14
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 16"

<400> 14
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 15
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 16"

<400> 15
Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 16
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.4"

<400> 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 17
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 20"

<400> 17
Asp Tyr Ala Met His 
1               5   


<210> 18
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 20"

<400> 18
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 19
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 20"

<400> 19
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 20
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.5"

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 21
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 24"

<400> 21
Ser Tyr Ala Met His 
1               5   


<210> 22
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 24"

<400> 22
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 23
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 24"

<400> 23
Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 24
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.6"

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 25
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 28"

<400> 25
Asp Tyr Ala Met His 
1               5   


<210> 26
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 28"

<400> 26
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 27
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 28"

<400> 27
Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 28
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.7"

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Ile Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 29
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 32"

<400> 29
Asp Tyr Ala Met His 
1               5   


<210> 30
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 32"

<400> 30
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 31
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 32"

<400> 31
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 32
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.8"

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 33
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 36"

<400> 33
Asp Tyr Ala Met His 
1               5   


<210> 34
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 36"

<400> 34
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 35
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 36"

<400> 35
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 36
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.9"

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Cys Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 37
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 40"

<400> 37
Asp Tyr Ala Met His 
1               5   


<210> 38
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 40"

<400> 38
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 39
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 40"

<400> 39
Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 40
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.10"

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Thr Gly Thr Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 41
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 44"

<400> 41
Asp Tyr Ala Met His 
1               5   


<210> 42
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 44"

<400> 42
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 43
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 44"

<400> 43
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 44
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.11"

<400> 44
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Lys Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 45
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 48"

<400> 45
Asp Tyr Ala Met His 
1               5   


<210> 46
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 48"

<400> 46
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 47
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 48"

<400> 47
Asp Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr His Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 48
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.12"

<400> 48
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr His 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 49
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 52"

<400> 49
Asp Tyr Ala Met His 
1               5   


<210> 50
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 52"

<400> 50
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 51
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 52"

<400> 51
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 52
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.13"

<400> 52
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 53
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 56"

<400> 53
Gly Tyr Ala Met His 
1               5   


<210> 54
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 56"

<400> 54
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 55
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 56"

<400> 55
Asp Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 56
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.14"

<400> 56
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 57
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 60"

<400> 57
Asp Tyr Ala Met His 
1               5   


<210> 58
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 60"

<400> 58
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 59
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 60"

<400> 59
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 60
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.15"

<400> 60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 61
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 64"

<400> 61
Asp Tyr Ala Met His 
1               5   


<210> 62
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 64"

<400> 62
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 63
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 64"

<400> 63
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210> 64
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.16"

<400> 64
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 65
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 68"

<400> 65
Asp Tyr Ala Met His 
1               5   


<210> 66
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 68"

<400> 66
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 67
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 68"

<400> 67
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 68
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.17"

<400> 68
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr His 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 69
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 72"

<400> 69
Asp Tyr Ala Met His 
1               5   


<210> 70
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 72"

<400> 70
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 71
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 72"

<400> 71
Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 72
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.18"

<400> 72
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Lys Gly Pro Gly Leu Ile Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210> 73
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 76"

<400> 73
Asp Tyr Ala Met His 
1               5   


<210> 74
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 76"

<400> 74
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 75
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 76"

<400> 75
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 76
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.19"

<400> 76
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 77
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 80"

<400> 77
Asp Tyr Ala Met His 
1               5   


<210> 78
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 80"

<400> 78
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 79
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 80"

<400> 79
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 80
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.20"

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 81
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.1"


<400> 81
gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gatcatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggaatg ggtctcaggt attagttgga atagtggcag tatgggctat      180

gcggactctg tgaaggaccg attcaccatc tccagagaca acgccaagag ctccctgtat      240

ctccaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accatggtca ccgtctcttc a                                                381


<210> 82
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.2"

<400> 82
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccggggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aaaagataag      300

gggcccggct taattggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcctc a                                                381


<210> 83
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.3"

<400> 83
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gccgggagtg ggtctcaggt attagttgga atagtggtag catgggctat      180

gcggactctg tgaaggaccg cttcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agcagaggac acggccctgt attattgtgt gaaagataag      300

gggcccggct taattggaag tacggccgat taccacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcttc a                                                381


<210> 84
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.4"

<400> 84
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgcc gattatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atggtggtag catgggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctgtat      240

ctgcaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggct taactggaac tacggccgat tactacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcttc a                                                381


<210> 85
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.5"

<400> 85
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccaggaaagg gcctggagtg ggtctcaggt attagttgga atggtggttc catgggctat      180

gcggactctg tgaaggaccg cttcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagactgag agctgaggac acggccttgt attattgtgt gaaagataag      300

gggcccggct taattggaag tacggccgat taccacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcttc a                                                381


<210> 86
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.6"

<400> 86
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atagtggtag tatgggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggcc taactggaac tacggccgat tattacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 87
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.7"

<400> 87
gaagtgcagc tggtggagtc tgggggaggc gtgatacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atggtggtag catgggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgcccagaa ttccctgtat      240

ctgcaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggct taactggaac tacggccgat tactacggta tggacgtctg gggccaaggg      360

accacggtca ctgtctcctc a                                                381


<210> 88
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.8"

<400> 88
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catgggctat      180

gcggactctg tgaaggaccg cttcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aaaagataag      300

gggcccggct taattggaag tacggccgat taccacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcctc a                                                381


<210> 89
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.9"

<400> 89
gaagtgcagc tggtggagtc tgggggaggc tgtgtacagc ctggcaggtc cctgagaatt       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atggtggtag catgggctat      180

gcggagtctg ttaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctacaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggct taattggaag tacggccgat tactacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 90
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.10"


<220>
<221> modified_base
<222> (226)..(226)
<223> a, c, t, g, unknown or other

<400> 90
gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gatcatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggaatg ggtctcaggt attagttgga atagtggcag tatgggctat      180

gcggactctg tgaaggaccg attcaccatc tccagagaca acgccnagag ctccctgtat      240

ctccaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accatggtca ccgtctcttc a                                                381


<210> 91
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.11"

<400> 91
gaggtgcagc tgttggagtc tgggggaggc tttgtacagc ctggcaggtc cctgagaatt       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctatat      240

ctgaaaatga acagtctgag agttgaggac acggccttgt attattgtgt aaaagataag      300

gggcccgggt taattggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcttc a                                                381


<210> 92
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.12"

<400> 92
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gactatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atggtggtag catgggctat      180

gcggactctg tgaaggaccg cttcaccatc tccagagaca acgccaagaa ctcactatat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt gaaagataag      300

gggcccggct taactggaag tacggccgat taccacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 93
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.13"

<400> 93
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgcccagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aaaagataag      300

gggcccggct taattggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcttc a                                                381


<210> 94
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.14"

<400> 94
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac ggttatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atagtggtag catgggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggct taactggaag tacggccgat tactacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 95
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.15"

<400> 95
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtacag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atagtggtag catgggctat      180

gcggagtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggct taattggaag tacggccgat tactacggta tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc a                                                381


<210> 96
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.16"

<400> 96
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gactatgcca tgcactgggt ccggcaggct      120

ccagggaagg gccgggagtg ggtctcagga attagttgga atggtggtag catgggctat      180

gcggagtctg ttaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctacaaatga acagtctgag agctgaggac tcggccttgt attattgtgt aaaagataag      300

gggcccggct taattggaag tacggccgat tactacggta tggacgtctg gggccaaggg      360

accacggtca ctgtctcctc a                                                381


<210> 97
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.17"

<400> 97
gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag catgggctat      180

gcggcctctg tgaaggaccg cttcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgac aactgaggac acggccttgt attattgtgt gaaagataag      300

gggcccggct taattggaag tacggccgat tatcacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcctc a                                                381


<210> 98
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.18"

<400> 98
caggtgcagc tggtggagtc tgggggaggc cttgtacagc ctggcaggtc cctgagactt       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctat      180

gcggcgtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctatat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aaaagataag      300

gggcccgggt taattggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcttc a                                                381


<210> 99
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.19"

<400> 99
caggtgcagc tggtggagtc tgggggaggc cttgtacagc ctggcaggtc cctgagactt       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctat      180

gcggcgtctg tgaagggccg attcaccatc tccagagaca acgccaagaa ttccctatat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aaaagataag      300

gggcccgggt taattggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accacggtca ctgtctcttc a                                                381


<210> 100
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.20"

<400> 100
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 101
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 104"

<400> 101
Asp Tyr Ala Met His 
1               5   


<210> 102
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 104"

<400> 102
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 103
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 104"

<400> 103
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 104
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.21"

<400> 104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 105
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 108"

<400> 105
Asp Tyr Ala Met His 
1               5   


<210> 106
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 108"

<400> 106
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 107
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 108"

<400> 107
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 108
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.22"

<400> 108
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 109
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 112"

<400> 109
Asp Tyr Ala Met His 
1               5   


<210> 110
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 112"

<400> 110
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 111
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 112"

<400> 111
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 112
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.23"

<400> 112
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 113
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 116"

<400> 113
Asp Tyr Ala Met His 
1               5   


<210> 114
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 116"

<400> 114
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 115
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 116"

<400> 115
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 116
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.24"

<400> 116
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 117
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 120"

<400> 117
Asp Tyr Ala Met His 
1               5   


<210> 118
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 120"

<400> 118
Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 119
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 120"

<400> 119
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 120
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.25"

<400> 120
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 121
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 124"

<400> 121
Asp Tyr Ala Met His 
1               5   


<210> 122
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 124"

<400> 122
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 123
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 124"

<400> 123
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 124
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.26"

<400> 124
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 125
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 128"

<400> 125
Asp Tyr Ala Met His 
1               5   


<210> 126
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 128"

<400> 126
Gly Ile Ser Trp Asn Gly Gly Ser Arg Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 127
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 128"

<400> 127
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 128
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.27"

<400> 128
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Arg Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 129
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 132"

<400> 129
Asp Tyr Ala Met His 
1               5   


<210> 130
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 132"

<400> 130
Gly Ile Ser Trp Asn Ala Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 131
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 132"

<400> 131
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 132
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.28"

<400> 132
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ala Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 133
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 136"

<400> 133
Asp Tyr Ala Met His 
1               5   


<210> 134
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 136"

<400> 134
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 135
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 136"

<400> 135
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210> 136
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.29"

<400> 136
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 137
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 140"

<400> 137
Asp Tyr Ala Gly His 
1               5   


<210> 138
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 140"

<400> 138
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 139
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 140"

<400> 139
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 140
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.30"

<400> 140
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Gly His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 141
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 144"

<400> 141
Asp Tyr Ala Leu His 
1               5   


<210> 142
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 144"

<400> 142
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 143
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 144"

<400> 143
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 144
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.31"

<400> 144
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 145
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 148"

<400> 145
Asp Tyr Ala Met His 
1               5   


<210> 146
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 148"

<400> 146
Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 147
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 148"

<400> 147
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 148
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.32"

<400> 148
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 149
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 152"

<400> 149
Asp Tyr Ala Met His 
1               5   


<210> 150
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 152"

<400> 150
Gly Ile Ser Trp Asn Gly Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 151
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 152"

<400> 151
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 152
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.33"

<400> 152
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 153
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 156"

<400> 153
Asp Tyr Ala Met His 
1               5   


<210> 154
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 156"

<400> 154
Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 155
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 156"

<400> 155
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 156
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.34"

<400> 156
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 157
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 160"

<400> 157
Asp Tyr Ala Met His 
1               5   


<210> 158
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 160"

<400> 158
Gly Ile Ser Trp Asn Gly Gly Ser Lys Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 159
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 160"

<400> 159
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 160
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.35"

<400> 160
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Lys Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 161
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 164"

<400> 161
Asp Tyr Ala Met His 
1               5   


<210> 162
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 164"

<400> 162
Gly Ile Ser Trp Asn Ala Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 163
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 164"

<400> 163
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 164
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.36"

<400> 164
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ala Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 165
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 168"

<400> 165
Asp Tyr Ala Phe His 
1               5   


<210> 166
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 168"

<400> 166
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 167
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 168"

<400> 167
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 168
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.37"

<400> 168
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 169
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 172"

<400> 169
Asp Tyr Ala Leu His 
1               5   


<210> 170
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 172"

<400> 170
Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 171
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 172"

<400> 171
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 172
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.38"

<400> 172
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 173
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 176"

<400> 173
Asp Tyr Ala Leu His 
1               5   


<210> 174
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 176"

<400> 174
Gly Ile Ser Trp Asn Gly Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 175
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 176"

<400> 175
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 176
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.39"

<400> 176
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 177
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 180"

<400> 177
Asp Tyr Ala Leu His 
1               5   


<210> 178
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 180"

<400> 178
Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 179
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 180"

<400> 179
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 180
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.40"

<400> 180
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 181
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 184"

<400> 181
Asp Tyr Ala Phe His 
1               5   


<210> 182
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 184"

<400> 182
Gly Ile Ser Trp Asn Gly Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 183
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 184"

<400> 183
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 184
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.41"

<400> 184
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 185
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 188"

<400> 185
Asp Tyr Ala Phe His 
1               5   


<210> 186
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 188"

<400> 186
Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 187
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 188"

<400> 187
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 188
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.42"

<400> 188
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 189
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 192"

<400> 189
Asp Tyr Ala Phe His 
1               5   


<210> 190
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 192"

<400> 190
Gly Ile Ser Trp Asn Ala Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 191
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 192"

<400> 191
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 192
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.43"

<400> 192
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ala Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 193
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 196"

<400> 193
Asp Tyr Ala Leu His 
1               5   


<210> 194
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 196"

<400> 194
Gly Ile Ser Trp Asn Ser Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 195
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 196"

<400> 195
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 196
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.44"

<400> 196
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 197
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 200"

<400> 197
Asp Tyr Ala Leu His 
1               5   


<210> 198
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 200"

<400> 198
Gly Ile Ser Trp Asn Ala Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 199
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 200"

<400> 199
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 200
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.45"

<400> 200
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ala Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 201
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 204"

<400> 201
Asp Tyr Ala Leu His 
1               5   


<210> 202
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 204"

<400> 202
Gly Ile Ser Trp Asn Ala Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 203
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 204"

<400> 203
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 204
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.46"

<400> 204
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ala Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 205
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 208"

<400> 205
Asp Tyr Ala Phe His 
1               5   


<210> 206
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 208"

<400> 206
Gly Ile Ser Trp Asn Ser Gly Ser Tyr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 207
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 208"

<400> 207
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 208
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.47"

<400> 208
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Tyr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 209
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 212"

<400> 209
Asp Tyr Ala Leu His 
1               5   


<210> 210
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 212"

<400> 210
Gly Ile Ser Trp Asn Ser Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 211
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 212"

<400> 211
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 212
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.48"

<400> 212
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 213
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 216"

<400> 213
Asp Tyr Ala Phe His 
1               5   


<210> 214
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 216"

<400> 214
Gly Ile Ser Trp Asn Ser Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 215
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 216"

<400> 215
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 216
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.49"

<400> 216
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 217
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 220"

<400> 217
Asp Tyr Ala Phe His 
1               5   


<210> 218
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 220"

<400> 218
Gly Ile Ser Trp Asn Ala Gly Ser Gln Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 219
<211> 18
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 220"

<400> 219
Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Ala 
        


<210> 220
<211> 127
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.50"

<400> 220
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe His Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ala Gly Ser Gln Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Lys Gly Pro Gly Leu Thr Gly Ser Thr Ala Asp Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Ala Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210> 221
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.21"

<400> 221
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 222
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.22"

<400> 222
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 223
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.23"

<400> 223
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 224
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.24"

<400> 224
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 225
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.25"

<400> 225
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ccagggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 226
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.26"

<400> 226
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 227
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.27"

<400> 227
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag caggggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 228
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.28"

<400> 228
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atgcgggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 229
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.29"

<400> 229
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgtctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 230
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.30"

<400> 230
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccg ggcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 231
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.31"

<400> 231
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggcctctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 232
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.32"

<400> 232
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 233
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.33"

<400> 233
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 234
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.34"

<400> 234
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 235
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.35"

<400> 235
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag caagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 236
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.36"

<400> 236
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atgcgggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 237
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.37"

<400> 237
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 238
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.38"

<400> 238
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag catgggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 239
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.39"

<400> 239
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tacactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 240
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.40"

<400> 240
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tacactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 241
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.41"

<400> 241
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 242
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.42"

<400> 242
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atggtggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 243
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.43"

<400> 243
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atgctggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 244
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.44"

<400> 244
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tacactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 245
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.45"

<400> 245
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tacactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atgctggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 246
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.46"

<400> 246
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tacactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atgctggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 247
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.47"

<400> 247
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag ctacggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 248
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.48"

<400> 248
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgccc tacactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 249
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.49"

<400> 249
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atagtggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 250
<211> 381
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 1.50"

<400> 250
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgac gattatgcct tccactgggt ccggcaagct      120

ccagggaagg acctggagtg ggtctcaggt attagttgga atgctggtag ccagggctac      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attattgtgt aagagaaaag      300

gggcccggct taactggaag tacggccgat tactacggtt tggacgcctg gggccaaggg      360

accatggtca ccgtctcctc a                                                381


<210> 251
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 254"

<400> 251
Asp Tyr Ala Met Ser 
1               5   


<210> 252
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 254"

<400> 252
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 253
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 254"

<400> 253
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 254
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.1"

<400> 254
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 255
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 258"

<400> 255
Asp Tyr Gly Met Ser 
1               5   


<210> 256
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 258"

<400> 256
Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala Lys 
1               5                   10                  15      


Asp 
    


<210> 257
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 258"

<400> 257
Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 258
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.2"

<400> 258
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 259
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 262"

<400> 259
Asp Tyr Gly Met Ser 
1               5   


<210> 260
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 262"

<400> 260
Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala Lys 
1               5                   10                  15      


Asp 
    


<210> 261
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 262"

<400> 261
Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 262
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.3"

<400> 262
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 263
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 266"

<400> 263
Asp Tyr Gly Met Ser 
1               5   


<210> 264
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 266"

<400> 264
Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala Lys 
1               5                   10                  15      


Asp 
    


<210> 265
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 266"

<400> 265
Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 266
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.4"

<400> 266
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 267
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 270"

<400> 267
Asp Tyr Gly Met Ser 
1               5   


<210> 268
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 270"

<400> 268
Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala Lys 
1               5                   10                  15      


Asp 
    


<210> 269
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 270"

<400> 269
Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 270
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.5"

<400> 270
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asn Gly Gly Ser Ala Gly Tyr Ser Asp Ser Ala 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 271
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 274"

<400> 271
Asp Tyr Gly Met Ser 
1               5   


<210> 272
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 274"

<400> 272
Gly Ile Ser Arg Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 273
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 274"

<400> 273
Asp Pro Tyr Ser Ser Gly Trp Ser Tyr Asp Ser Phe Asp Ile 
1               5                   10                  


<210> 274
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.6"

<400> 274
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Leu Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Val Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Ser Ser Gly Trp Ser Tyr Asp Ser Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 275
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 278"

<400> 275
Asp Tyr Gly Met Ser 
1               5   


<210> 276
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 278"

<400> 276
Gly Ile Ser Arg Asn Gly Gly Ser Thr Gly Tyr Thr Ala Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 277
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 278"

<400> 277
Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 278
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.7"

<400> 278
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Arg Asn Gly Gly Ser Thr Gly Tyr Thr Ala Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Tyr Ser Ser Gly Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 279
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 282"

<400> 279
Asp Tyr Ala Met Ser 
1               5   


<210> 280
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 282"

<400> 280
Gly Ile Ser Trp Asn Gly Gly Ser Ala Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 281
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 282"

<400> 281
Asp Pro His Ser Ser Ala Trp Ser Tyr Asp Ala Phe Asp Ile 
1               5                   10                  


<210> 282
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.8"

<400> 282
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Ala Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro His Ser Ser Ala Trp Ser Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 283
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 286"

<400> 283
Asp Tyr Ala Met Ser 
1               5   


<210> 284
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 286"

<400> 284
Gly Ile Ser Trp Asn Gly Gly Ser Lys Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 285
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 286"

<400> 285
Asp Pro Tyr Ser Gly Ala Trp Ser Tyr Asp Ala Phe Asp Ile 
1               5                   10                  


<210> 286
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.9"

<400> 286
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Lys Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Ser Gly Ala Trp Ser Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 287
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 290"

<400> 287
Asp Tyr Ala Met Ser 
1               5   


<210> 288
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 290"

<400> 288
Gly Ile Ser Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 289
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 290"

<400> 289
Asp Pro Tyr Ser Gly Ala Trp Ser Tyr Asp Ala Phe Asp Ile 
1               5                   10                  


<210> 290
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.10"

<400> 290
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Tyr Ser Gly Ala Trp Ser Tyr Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 291
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 294"

<400> 291
Asn Tyr Ala Met Ser 
1               5   


<210> 292
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 294"

<400> 292
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 293
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 294"

<400> 293
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Thr Phe Asp Ile 
1               5                   10                  


<210> 294
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.11"

<400> 294
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Thr Phe Asp Ile 
            100                 105                 110         


Arg Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 295
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 298"

<400> 295
Asp Tyr Ala Met Ser 
1               5   


<210> 296
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 298"

<400> 296
Gly Ile Thr Trp Asn Ala Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 297
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 298"

<400> 297
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 298
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.12"

<400> 298
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Ala Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 299
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 302"

<400> 299
Asp Tyr Ala Met Ser 
1               5   


<210> 300
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 302"

<400> 300
Gly Ile Thr Trp Asn Arg Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 301
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 302"

<400> 301
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 302
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.13"

<400> 302
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Arg Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 303
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 306"

<400> 303
Asp Tyr Ala Phe Ser 
1               5   


<210> 304
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 306"

<400> 304
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 305
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 306"

<400> 305
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 306
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.14"

<400> 306
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 307
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 310"

<400> 307
Asp Tyr Ala Gln Ser 
1               5   


<210> 308
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 310"

<400> 308
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 309
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 310"

<400> 309
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 310
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.15"

<400> 310
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Gln Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 311
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 314"

<400> 311
Asp Tyr Ala Asn Ser 
1               5   


<210> 312
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 314"

<400> 312
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 313
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 314"

<400> 313
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 314
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.16"

<400> 314
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Asn Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 315
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 318"

<400> 315
Asp Tyr Ala Gly Ser 
1               5   


<210> 316
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 318"

<400> 316
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 317
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 318"

<400> 317
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 318
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.17"

<400> 318
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Gly Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 319
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 322"

<400> 319
Asp Tyr Ala Glu Ser 
1               5   


<210> 320
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 322"

<400> 320
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 321
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 322"

<400> 321
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 322
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.18"

<400> 322
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Glu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 323
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 326"

<400> 323
Asp Tyr Ala Trp Ser 
1               5   


<210> 324
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 326"

<400> 324
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 325
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 326"

<400> 325
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 326
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.19"

<400> 326
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Trp Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 327
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 330"

<400> 327
Asp Tyr Ala Val Ser 
1               5   


<210> 328
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 330"

<400> 328
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 329
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 330"

<400> 329
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 330
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.20"

<400> 330
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 331
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 334"

<400> 331
Asp Tyr Ala Leu Ser 
1               5   


<210> 332
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 334"

<400> 332
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 333
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 334"

<400> 333
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 334
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.21"

<400> 334
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 335
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 338"

<400> 335
Asp Tyr Ala Ser Ser 
1               5   


<210> 336
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 338"

<400> 336
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 337
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 338"

<400> 337
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 338
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.22"

<400> 338
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ser Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 339
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 342"

<400> 339
Asp Tyr Ala Arg Ser 
1               5   


<210> 340
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 342"

<400> 340
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 341
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 342"

<400> 341
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 342
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.23"

<400> 342
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Arg Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 343
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 346"

<400> 343
Asp Tyr Ala Met Ser 
1               5   


<210> 344
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 346"

<400> 344
Gly Ile Thr Trp Asn Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 345
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 346"

<400> 345
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 346
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.24"

<400> 346
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Ser Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 347
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 350"

<400> 347
Asp Tyr Ala Met Ser 
1               5   


<210> 348
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 350"

<400> 348
Gly Ile Thr Trp Asn Gln Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 349
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 350"

<400> 349
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 350
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.25"

<400> 350
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gln Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 351
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 354"

<400> 351
Asp Tyr Ala Met Ser 
1               5   


<210> 352
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 354"

<400> 352
Gly Ile Thr Trp Asn His Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 353
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 354"

<400> 353
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Val Phe Asp Ile 
1               5                   10                  


<210> 354
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.26"

<400> 354
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn His Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 355
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 358"

<400> 355
Asp Tyr Ala Met Ser 
1               5   


<210> 356
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 358"

<400> 356
Gly Ile Thr Trp Asn Ala Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 357
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 358"

<400> 357
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 358
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.27"

<400> 358
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Ala Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 359
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 362"

<400> 359
Asp Tyr Ala Met Ser 
1               5   


<210> 360
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 362"

<400> 360
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 361
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 362"

<400> 361
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Val Phe Asp Ile 
1               5                   10                  


<210> 362
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.28"

<400> 362
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 363
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 366"

<400> 363
Asp Tyr Ala Met Ser 
1               5   


<210> 364
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 366"

<400> 364
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 365
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 366"

<400> 365
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 366
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.29"

<400> 366
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 367
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 370"

<400> 367
Asp Tyr Ala Met Ser 
1               5   


<210> 368
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 370"

<400> 368
Gly Ile Thr Trp Asn Lys Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 369
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 370"

<400> 369
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 370
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.30"

<400> 370
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Lys Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 371
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 374"

<400> 371
Asp Tyr Ala Met Ser 
1               5   


<210> 372
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 374"

<400> 372
Gly Ile Thr Trp Asn Arg Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 373
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 374"

<400> 373
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 374
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.31"

<400> 374
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Arg Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 375
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 378"

<400> 375
Asp Tyr Ala Ile Ser 
1               5   


<210> 376
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 378"

<400> 376
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 377
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 378"

<400> 377
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 378
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.32"

<400> 378
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 379
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 382"

<400> 379
Asp Tyr Ala Thr Ser 
1               5   


<210> 380
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 382"

<400> 380
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 381
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 382"

<400> 381
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 382
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.33"

<400> 382
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Thr Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 383
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 386"

<400> 383
Asp Tyr Ala Asn Ser 
1               5   


<210> 384
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 386"

<400> 384
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 385
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 386"

<400> 385
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 386
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.34"

<400> 386
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Asn Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 387
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 390"

<400> 387
Asp Tyr Ala Asp Ser 
1               5   


<210> 388
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 390"

<400> 388
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 389
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 390"

<400> 389
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 390
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.35"

<400> 390
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Asp Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 391
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 394"

<400> 391
Asp Tyr Ala Ser Ser 
1               5   


<210> 392
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 394"

<400> 392
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 393
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 394"

<400> 393
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 394
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.36"

<400> 394
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Ser Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 395
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 398"

<400> 395
Asp Tyr Ala Leu Ser 
1               5   


<210> 396
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 398"

<400> 396
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 397
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 398"

<400> 397
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 398
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.37"

<400> 398
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 399
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 402"

<400> 399
Asp Tyr Ala Gly Ser 
1               5   


<210> 400
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 402"

<400> 400
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 401
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 402"

<400> 401
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 402
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.38"

<400> 402
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Gly Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 403
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 406"

<400> 403
Asp Tyr Ala Glu Ser 
1               5   


<210> 404
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 406"

<400> 404
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 405
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 406"

<400> 405
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 406
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.39"

<400> 406
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Glu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 407
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 410"

<400> 407
Asp Tyr Ala Trp Ser 
1               5   


<210> 408
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 410"

<400> 408
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 409
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 410"

<400> 409
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 410
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.40"

<400> 410
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Trp Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 411
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 414"

<400> 411
Asp Tyr Ala Arg Ser 
1               5   


<210> 412
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 414"

<400> 412
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 413
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 414"

<400> 413
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 414
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.41"

<400> 414
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Arg Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 415
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 418"

<400> 415
Asp Tyr Ala Phe Ser 
1               5   


<210> 416
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 418"

<400> 416
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 417
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 418"

<400> 417
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 418
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.42"

<400> 418
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 419
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 422"

<400> 419
Asp Tyr Ala Val Ser 
1               5   


<210> 420
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 422"

<400> 420
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 421
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 422"

<400> 421
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 422
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.43"

<400> 422
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 423
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 426"

<400> 423
Asp Tyr Ala Met Ser 
1               5   


<210> 424
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 426"

<400> 424
Gly Ile Thr Trp Thr Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 425
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 426"

<400> 425
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 426
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.44"

<400> 426
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Thr Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 427
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 430"

<400> 427
Asp Tyr Ala Met Ser 
1               5   


<210> 428
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 430"

<400> 428
Gly Ile Thr Trp Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 429
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 430"

<400> 429
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 430
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.45"

<400> 430
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Ser Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 431
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 434"

<400> 431
Asp Tyr Ala Met Ser 
1               5   


<210> 432
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 434"

<400> 432
Gly Ile Thr Trp Pro Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 433
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 434"

<400> 433
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 434
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.46"

<400> 434
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Pro Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 435
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 438"

<400> 435
Asp Tyr Ala Met Ser 
1               5   


<210> 436
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 438"

<400> 436
Gly Ile Thr Trp Ile Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 437
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 438"

<400> 437
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 438
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.47"

<400> 438
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Ile Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 439
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 442"

<400> 439
Asp Tyr Ala Met Ser 
1               5   


<210> 440
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 442"

<400> 440
Gly Ile Thr Trp Leu Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 441
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 442"

<400> 441
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 442
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.48"

<400> 442
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Leu Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 443
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 446"

<400> 443
Asp Tyr Ala Met Ser 
1               5   


<210> 444
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 446"

<400> 444
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 445
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 446"

<400> 445
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 446
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.49"

<400> 446
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 447
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 450"

<400> 447
Asp Tyr Ala Met Ser 
1               5   


<210> 448
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 450"

<400> 448
Gly Ile Thr Trp Lys Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 449
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 450"

<400> 449
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 450
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.50"

<400> 450
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Lys Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 451
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 454"

<400> 451
Asp Tyr Ala Met Ser 
1               5   


<210> 452
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 454"

<400> 452
Gly Ile Thr Trp Arg Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 453
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 454"

<400> 453
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
1               5                   10                  


<210> 454
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.51"

<400> 454
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Arg Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Gly Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 455
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 458"

<400> 455
Asp Tyr Ala Met Ser 
1               5   


<210> 456
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 458"

<400> 456
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 457
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 458"

<400> 457
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Val Phe Asp Ile 
1               5                   10                  


<210> 458
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.52"

<400> 458
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 459
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR1 sequence of SEQ ID NO: 462"

<400> 459
Asp Tyr Ala Met Ser 
1               5   


<210> 460
<211> 17
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR2 sequence of SEQ ID NO: 462"

<400> 460
Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210> 461
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="CDR3 sequence of SEQ ID NO: 462"

<400> 461
Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
1               5                   10                  


<210> 462
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.53"

<400> 462
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Trp Asn Gly Gly Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Tyr Ser Tyr Ala Trp Ser Tyr Asp Asp Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 463
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.1"

<400> 463
gaagtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcact      360

gtctcctca                                                              369


<210> 464
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.2"

<400> 464
gaggtgcagc tgttggagtc tgggggaggt gtggtgcggc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaacct      120

ccagggaagg ggctggagtg ggtctctggt ataagtagga atggtggtag cgcaggttat      180

tcagactctg cgaaggaccg atttaccatc tccagagaca acgccaagaa ctccctctat      240

ctgcaaatga acagtctgag agccgacgac acggccatgt attattgtgc gagagagaag      300

tatagcagtg gctggtccta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 465
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.3"

<400> 465
caggtgcagc tggtggagtc tgggggaggt gtggtgcggc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaatct      120

ccagggaagg ggctggagtg ggtctctggt attagtagga atggtggtag cgcaggttat      180

tcagactctg cgaaggaccg atttaccatc tccagagaca acgccaagaa ctccctctat      240

ctgcaaatga acagtctgag agccgacgac acggccatgt attattgtgc gagagagaag      300

tatagcagtg gctggtccta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 466
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.4"

<400> 466
caggtgcagc tggtggagtc tgggggaggt gtggtgcggc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaacct      120

ccagggaagg ggctggagtg ggtctctggt attagtagga atggtggtag cgcaggttat      180

tcagactctg cgaaagaccg atttaccatc tccagagaca acgccaagaa ctccctctat      240

ctgcaaatga acagtctgag agccgacgac acggccatgt attattgtgc gagagagaag      300

tatagcagtg gctggtccta tgatgatttt gatatctggg gccaagggac aatggtcact      360

gtctcttca                                                              369


<210> 467
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.5"

<400> 467
gaagtgcagc tggtggagtc tgggggaggt gtggtgcggc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaacct      120

ccagggaagg ggctggagtg ggtctctggt attagtagga atggtggtag cgcaggttat      180

tcagactctg cgaaggaccg atttaccatc tccagagaca acgccaagaa ctccctctat      240

ctgcaaatga acagtctgag agccgacgac acggccatgt attattgtgc gagagagaag      300

tatagcagtg gctggtccta tgatgatttt gatatctggg gccaagggac aatggtcact      360

gtctcctca                                                              369


<210> 468
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.6"

<400> 468
caggtgcagc tggtggagtc tgggggaggt gtggtacggc ttggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagctttgtt gattatggca tgagctgggt ccgacaagct      120

ccagggcagg ggctggagtg ggtctctggt attagtagga acggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa caccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgc gagagaccct      300

tatagcagtg gctggtccta tgattctttt gatatctggg gccaggggac aatggtcact      360

gtctcctca                                                              369


<210> 469
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.7"

<400> 469
caggtgcagc tggtggagtc tgggggaggt gtggttcggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaagct      120

ccagggaagg gactggagtg ggtctctggt attagtcgga atggtggtag tacagggtat      180

acagcctctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgacgac acagccatgt attactgtgc gcgagagaag      300

tatagcagtg gctggtccta tgatgacttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 470
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.8"

<400> 470
caggtgcagc tggtggagtc tgggggaggc ctggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attagttgga atggtggtag cgcaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgc gagagatccc      300

catagcagtg cctggtccta tgatgctttt gatatctggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210> 471
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.9"

<400> 471
caggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttgat gattatgcca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attagttgga atggtggtag taaaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttat attactgtgc gagagatccg      300

tatagcggtg cctggtccta tgatgctttt gatatctggg gccaagggac aatggtcact      360

gtctcctca                                                              369


<210> 472
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.10"

<400> 472
caggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attagttgga atggtggtag tacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttat attactgtgc gagagatccg      300

tatagcggtg cctggtccta tgatgctttt gatatctggg gccaagggac aatggtcact      360

gtctcttca                                                              369


<210> 473
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.11"

<400> 473
caggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat aattatgcca tgagctgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgc gagagacaag      300

tatagctatg cctggtctta tgatactttt gatatccggg gccaagggac aatggtcacc      360

gtctcttca                                                              369


<210> 474
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.12"

<400> 474
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atgccggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 475
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.13"

<400> 475
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atcggggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 476
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.14"

<400> 476
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcct tcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 477
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.15"

<400> 477
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccc agagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 478
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.16"

<400> 478
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca acagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 479
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.17"

<400> 479
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg ggagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 480
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.18"

<400> 480
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg agagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 481
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.19"

<400> 481
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcct ggagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 482
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.20"

<400> 482
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg tcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 483
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.21"

<400> 483
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcct tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 484
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.22"

<400> 484
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca gcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 485
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.23"

<400> 485
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccc ggagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 486
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.24"

<400> 486
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga attcgggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 487
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.25"

<400> 487
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atcagggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 488
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.26"

<400> 488
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atcacggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgtgttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 489
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.27"

<400> 489
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atgccggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 490
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.28"

<400> 490
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgtgttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 491
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.29"

<400> 491
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 492
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.30"

<400> 492
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga ataagggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 493
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.31"

<400> 493
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atcgcggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 494
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.32"

<400> 494
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 495
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.33"

<400> 495
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca ccagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 496
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.34"

<400> 496
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca acagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 497
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.35"

<400> 497
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg acagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 498
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.36"

<400> 498
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca gcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 499
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.37"

<400> 499
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccc tcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 500
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.38"

<400> 500
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg ggagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 501
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.39"

<400> 501
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg agagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 502
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.40"

<400> 502
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcct ggagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 503
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.41"

<400> 503
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccc ggagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 504
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.42"

<400> 504
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcct tcagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 505
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.43"

<400> 505
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgccg tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 506
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.44"

<400> 506
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga ccggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 507
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.45"

<400> 507
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttggt ccggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 508
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.46"

<400> 508
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttggc ccggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 509
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.47"

<400> 509
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga tcggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 510
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.48"

<400> 510
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttggc tgggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 511
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.49"

<400> 511
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 512
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.50"

<400> 512
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga agggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 513
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.51"

<400> 513
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttggc ggggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatggtttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 514
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.52"

<400> 514
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgtgttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 515
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<221> source
<223> /note="VH 2.53"

<400> 515
gaggtgcagc tggtggagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgagttgggt ccgccaagct      120

ccagggaagg ggctggagtg ggtctctggt attacttgga atggtggtag cacaggttat      180

gcagactctg tgaaggaccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agccgaggac acggccttgt attactgtgt gagagacaag      300

tatagctatg cctggtctta tgatgatttt gatatctggg gccaagggac aatggtcacc      360

gtctcctca                                                              369


<210> 516
<211> 5
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Termination sequence of a human VH domain"

<400> 516
Val Thr Val Ser Ser 
1               5   


<210> 517
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 517
His His His His His His 
1               5       


<210> 518
<211> 288
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Wild type human PD-1 protein"

<400> 518
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210> 519
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Residues 102-115 of human PD-1"

<400> 519
Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg 
1               5                   10                  


<210> 520
<211> 6
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 520
Asn Pro Pro Thr Phe Ser 
1               5       


<210> 521
<211> 14
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 521
Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp 
1               5                   10                  


<210> 522
<211> 10
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 522
Pro Asn Gly Arg Asp Phe His Met Ser Val 
1               5                   10  


<210> 523
<211> 12
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 523
Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
1               5                   10          


<210> 524
<211> 9
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 524
Gly Gln Asp Cys Arg Phe Arg Val Thr 
1               5                   


<210> 525
<211> 11
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 525
Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
1               5                   10      


<210> 526
<211> 7
<212> PRT
<213> Homo sapiens

<220>
<221> source
<223> /note="Binding motif in human PD-1"

<400> 526
Arg Asp Phe His Met Ser Val 
1               5           


<210> 527
<211> 14
<212> PRT
<213> Mus sp.

<220>
<221> source
<223> /note="Murine PD-1"

<400> 527
Asn Arg His Asp Phe His Met Asn Ile Leu Asp Thr Arg Arg 
1               5                   10                  


<210> 528
<211> 125
<212> PRT
<213> Homo sapiens


<400> 441
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Glu 
            20                  25                  30          


Ser Met Thr Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Gly Val Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Pro Leu Arg Leu Gly Glu Ser Pro His Asp Ala Phe 
            100                 105                 110         


Asp Ile Ser Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 



<210> 529
<211> 125
<212> PRT
<213> Homo sapiens


<400> 381
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Ser Met Thr Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Gly Val Lys Phe Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Pro Leu Arg Leu Gly Glu Ser Pro His Asp Ala Phe 
            100                 105                 110         


Asp Ile Ser Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 
