                               SEQUENCE LISTING

<110> BICYCLE THERAPEUTICS LIMITED
 
<120> COMPOUNDS FOR TREATING CANCER

<130> BIC-C-P2296PCT

<140>
<141>

<150> 62/443,508
<151> 2017-01-06

<160> 17    

<170> PatentIn version 3.5

<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> /replace="Cys" or "Gln" or "Met" or "Ser" or "Thr" or "Gly"
      or "Ala" or "Ile" or "Leu" or "Pro" or "Val"

<220>
<221> MOD_RES
<222> (4)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Any amino acid

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 1
Cys Xaa Asn Xaa Xaa Gly Glu Asp Phe Tyr Xaa Xaa Cys 
1               5                   10              


<210> 2
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 3
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> D-Ala

<400> 4
Cys Xaa Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 5
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> D-Ala

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 1Nal

<220>
<221> MOD_RES
<222> (6)..(6)
<223> D-Ala

<220>
<221> MOD_RES
<222> (13)..(13)
<223> tBuGly

<400> 5
Cys Xaa Asn Glu Xaa Xaa Cys Glu Asp Phe Tyr Asp Xaa Cys 
1               5                   10                  


<210> 6
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> /replace="Met" or "Phe" or "Val"

<220>
<221> MOD_RES
<222> (3)..(3)
<223> /replace="Cys" or "Gln" or "Met" or "Ser" or "Thr" or "Gly"
      or "Ala" or "Ile" or "Leu" or "Pro" or "Val"


<220>
<221> MOD_RES
<222> (4)..(4)
<223> /replace="Cys" or "Gln" or "Met" or "Ser" or "Thr" or 
      "Asp" or "Glu"

<220>
<221> MOD_RES
<222> (5)..(5)
<223> /replace="Trp" or "Tyr"

<220>
<221> MOD_RES
<222> (12)..(12)
<223> /replace="Glu"

<220>
<221> MOD_RES
<222> (13)..(13)
<223> /replace="Ala" or "Ile" or "Leu" or "Pro" or "Val"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 6
Cys Tyr Asn Asn Phe Gly Cys Glu Asp Phe Tyr Asp Gly Cys 
1               5                   10                  


<210> 7
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> /replace="Met" or "Phe" or "Val"

<220>
<221> MOD_RES
<222> (3)..(3)
<223> /replace="Gly"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> /replace="Gln"

<400> 7
Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 8
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> /replace="Met" or "Phe"

<220>
<221> MOD_RES
<222> (3)..(3)
<223> /replace="Gly"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> /replace="Gln"

<400> 8
Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 9
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> /replace="Met" 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> /replace="Gln" 

<400> 9
Cys Tyr Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 10
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Cys Met Asn Gln Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 11
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Cys Phe Gly Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 12
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Cys Val Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 13
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Cys Phe Asn Glu Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 14
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Cys Tyr Asn Glu Tyr Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Cys Tyr Asn Glu Trp Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  


<210> 16
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Cys Lys Asn Arg Gly Phe Gly Cys Glu Asp Phe Tyr Asp Ile Cys 
1               5                   10                  15  


<210> 17
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> B-Ala

<220>
<221> MOD_RES
<222> (2)..(11)
<223> Sarcosine

<400> 17
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Cys Val Pro Cys 
1               5                   10                  15      


Ala Asp Phe Pro Ile Trp Tyr Cys 
            20                  


