                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, as represented by the 
       Secretary, Department of Health and Human Services
       Caughey, Byron  W
       Saijo, Eri
       Kraus, Allison
       Metrick, Michael
 
<120>  METHODS FOR THE DETECTION OF TAU PROTEIN AGGREGATES

<130>  4239-97956-02

<150>  62/440,885
<151>  2016-12-30

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  1

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
                85                  90                  95      


Lys Ile Glu 
            


<210>  2
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  2

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
                85                  90                  95      


Lys Ile Glu 
            


<210>  3
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  3

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        35                  40                  45              


Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    50                  55                  60                  


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
65                  70                  75                  80  


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                85                  90                  95      


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            100                 105                 110         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        115                 120                 125             


Ile Glu 
    130 


<210>  4
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  4

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        35                  40                  45              


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    50                  55                  60                  


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
65                  70                  75                  80  


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                85                  90                  95      


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            100                 105                 110         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        115                 120                 125             


Ile Glu 
    130 


<210>  5
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  5

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
                85                  90                  95      


Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys 
            100                 105                 110         


Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
        115                 120                 125         


<210>  6
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  6

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Ala Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
                85                  90                  95      


Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys 
            100                 105                 110         


Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
        115                 120                 125         


<210>  7
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  7

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
                85                  90                  95      


Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys 
            100                 105                 110         


Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
        115                 120                 125         


<210>  8
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  9
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
                245                 250                 255     


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            260                 265                 270         


Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
        275                 280                 285             


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
    290                 295                 300                 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
305                 310                 315                 320 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
                325                 330                 335     


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
            340                 345                 350         


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
        355                 360                 365             


Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser 
    370                 375                 380                 


Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
385                 390                 395                 400 


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410         


<210>  10
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
    210                 215                 220                 


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
225                 230                 235                 240 


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                245                 250                 255     


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            260                 265                 270         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        275                 280                 285             


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    290                 295                 300                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
305                 310                 315                 320 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                325                 330                 335     


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
            340                 345                 350         


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
        355                 360                 365             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380             


<210>  11
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
        275                 280                 285             


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
    290                 295                 300                 


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
305                 310                 315                 320 


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
                325                 330                 335     


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
            340                 345                 350         


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
        355                 360                 365             


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
    370                 375                 380                 


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
385                 390                 395                 400 


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410 


<210>  12
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                245                 250                 255     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            260                 265                 270         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        275                 280                 285             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    290                 295                 300                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
305                 310                 315                 320 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                325                 330                 335     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            340                 345                 350         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        355                 360                 365             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380     


<210>  13
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val 
    210                 215                 220                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
225                 230                 235                 240 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                245                 250                 255     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            260                 265                 270         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        275                 280                 285             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    290                 295                 300                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
305                 310                 315                 320 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                325                 330                 335     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345                 350         


<210>  14
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  14

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu 
        115                 


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  15

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu 
        115                 


<210>  16
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  16

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
                85                  90                  95      


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
            100                 105                 110         


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
        115                 120                 125             


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
    130                 135                 140                 


Gly Asn Lys Lys Ile Glu 
145                 150 


<210>  17
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  17

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
                85                  90                  95      


Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
            100                 105                 110         


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
        115                 120                 125             


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
    130                 135                 140                 


Gly Asn Lys Lys Ile Glu 
145                 150 


<210>  18
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  18

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
        115                 120                 125             


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
    130                 135                 140                 


Val Val Ser 
145         


<210>  19
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  19

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Ala Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
        115                 120                 125             


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
    130                 135                 140                 


Val Val Ser 
145         


<210>  20
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  20

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
        115                 120                 125             


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
    130                 135                 140                 


Val Val Ser 
145         


<210>  21
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  21

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
65                  70                  75                  80  


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr 
                85                  90                  95      


Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln 
            100                 105                 110         


Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
        115                 120                 125             


Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln 
    130                 135                 140                 


Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys 
145                 150                 155                 160 


Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly 
                165                 170                 175     


Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro 
            180                 185                 190         


Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro 
        195                 200                 205             


Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
    210                 215                 220                 


Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
225                 230                 235                 240 


Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
                245                 250                 255     


Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
            260                 265                 270         


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
        275                 280                 285             


Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu 
    290                 295                 300                 


Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
305                 310                 315                 320 


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                325                 330                 335     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            340                 345                 350         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        355                 360                 365             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    370                 375                 380                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
385                 390                 395                 400 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                405                 410                 415     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            420                 425                 430         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        435                 440                 445             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    450                 455                 460     


<210>  22
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis human Tau 34

<400>  22

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
65                  70                  75                  80  


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Glu Glu 
                85                  90                  95      


Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His 
            100                 105                 110         


Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser 
        115                 120                 125             


Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr 
    130                 135                 140                 


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
145                 150                 155                 160 


Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser 
                165                 170                 175     


Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
            180                 185                 190         


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
        195                 200                 205             


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
    210                 215                 220                 


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
225                 230                 235                 240 


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
                245                 250                 255     


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
            260                 265                 270         


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
        275                 280                 285             


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
    290                 295                 300                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
305                 310                 315                 320 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                325                 330                 335     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            340                 345                 350         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        355                 360                 365             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    370                 375                 380                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
385                 390                 395                 400 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                405                 410                 415     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430         


<210>  23
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis human Tau 24

<400>  23

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly 
                85                  90                  95      


Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys 
            100                 105                 110         


Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala 
        115                 120                 125             


Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro 
    130                 135                 140                 


Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
145                 150                 155                 160 


Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser 
                165                 170                 175     


Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
            180                 185                 190         


Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala 
        195                 200                 205             


Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
    210                 215                 220                 


Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile 
225                 230                 235                 240 


Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
                245                 250                 255     


Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
            260                 265                 270         


Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly 
        275                 280                 285             


Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
    290                 295                 300                 


Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp 
305                 310                 315                 320 


Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
                325                 330                 335     


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            340                 345                 350         


Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg 
        355                 360                 365             


His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser 
    370                 375                 380                 


Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys 
385                 390                 395                 400 


Gln Gly Leu 
            


<210>  24
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis human Tau 39

<400>  24

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
65                  70                  75                  80  


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr 
                85                  90                  95      


Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln 
            100                 105                 110         


Pro His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
        115                 120                 125             


Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln 
    130                 135                 140                 


Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys 
145                 150                 155                 160 


Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly 
                165                 170                 175     


Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro 
            180                 185                 190         


Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro 
        195                 200                 205             


Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
    210                 215                 220                 


Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
225                 230                 235                 240 


Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro 
                245                 250                 255     


Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
            260                 265                 270         


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
        275                 280                 285             


Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
    290                 295                 300                 


Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
305                 310                 315                 320 


Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys 
                325                 330                 335     


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
            340                 345                 350         


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
        355                 360                 365             


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
    370                 375                 380                 


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val 
385                 390                 395                 400 


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
                405                 410                 415     


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430 


<210>  25
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis human Tau 37

<400>  25

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Glu Ser Pro Leu Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly 
65                  70                  75                  80  


Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Glu Glu 
                85                  90                  95      


Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His 
            100                 105                 110         


Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser 
        115                 120                 125             


Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr 
    130                 135                 140                 


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
145                 150                 155                 160 


Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser 
                165                 170                 175     


Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
            180                 185                 190         


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
        195                 200                 205             


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
    210                 215                 220                 


Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
225                 230                 235                 240 


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
                245                 250                 255     


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro 
            260                 265                 270         


Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile 
        275                 280                 285             


His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
    290                 295                 300                 


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
305                 310                 315                 320 


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
                325                 330                 335     


Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile 
            340                 345                 350         


Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
        355                 360                 365             


Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln 
    370                 375                 380                 


Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly 
385                 390                 395                 400 


Leu 
    


<210>  26
<211>  372
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6XHis human Tau 23

<400>  26

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu 
            20                  25                  30          


Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly 
        35                  40                  45              


Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys 
    50                  55                  60                  


Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala 
65                  70                  75                  80  


Ala Gly His Val Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly 
                85                  90                  95      


Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys 
            100                 105                 110         


Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala 
        115                 120                 125             


Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro 
    130                 135                 140                 


Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser 
145                 150                 155                 160 


Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser 
                165                 170                 175     


Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
            180                 185                 190         


Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala 
        195                 200                 205             


Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
    210                 215                 220                 


Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val 
225                 230                 235                 240 


Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu 
                245                 250                 255     


Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser 
            260                 265                 270         


Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu 
        275                 280                 285             


Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr 
    290                 295                 300                 


His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly 
305                 310                 315                 320 


Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro 
                325                 330                 335     


Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp 
            340                 345                 350         


Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala 
        355                 360                 365             


Lys Gln Gly Leu 
    370         


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hexapeptide PHF6

<400>  27

Val Gln Ile Val Tyr Lys 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hexapeptide PHF6*

<400>  28

Val Gln Ile Ile Asn Lys 
1               5       


<210>  29
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  29

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
        35                  40                  45              


Ala Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
    50                  55                  60                  


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
65                  70                  75                  80  


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
                85                  90                  95      


Lys Ile Glu 
            


<210>  30
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  30

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        35                  40                  45              


Ala Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    50                  55                  60                  


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
65                  70                  75                  80  


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                85                  90                  95      


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            100                 105                 110         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        115                 120                 125             


Ile Glu 
    130 


<210>  31
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  31

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        35                  40                  45              


Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    50                  55                  60                  


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ala 
65                  70                  75                  80  


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                85                  90                  95      


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            100                 105                 110         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        115                 120                 125             


Ile Glu 
    130 


<210>  32
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  32

Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30          


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
        35                  40                  45              


Ala Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
    50                  55                  60                  


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ala 
65                  70                  75                  80  


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
                85                  90                  95      


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
            100                 105                 110         


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        115                 120                 125             


Ile Glu 
    130 


<210>  33
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  33

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Ala Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu 
        115                 


<210>  34
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  34

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ala Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
                85                  90                  95      


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
            100                 105                 110         


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
        115                 120                 125             


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
    130                 135                 140                 


Gly Asn Lys Lys Ile Glu 
145                 150 


<210>  35
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  35

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
                85                  90                  95      


Thr Ser Lys Ala Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
            100                 105                 110         


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
        115                 120                 125             


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
    130                 135                 140                 


Gly Asn Lys Lys Ile Glu 
145                 150 


<210>  36
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  36

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ala Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
                85                  90                  95      


Thr Ser Lys Ala Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
            100                 105                 110         


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
        115                 120                 125             


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
    130                 135                 140                 


Gly Asn Lys Lys Ile Glu 
145                 150 


<210>  37
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  microtubule binding domain

<400>  37

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        35                  40                  45              


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    50                  55                  60                  


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
65                  70                  75                  80  


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                85                  90                  95      


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            100                 105                 110         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        115                 120                 125         


<210>  38
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  microtubule binding domain

<400>  38

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
65                  70                  75                  80  


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
                85                  90                  95      


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  39

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
    50                  55                  60                  


Val Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
65                  70                  75                  80  


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
                85                  90                  95      


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
            100                 105                 110         


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
        115                 120                 125 


<210>  40
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  40

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
65                  70                  75                  80  


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
                85                  90                  95      


Ile Glu Thr His Lys Leu Thr Phe 
            100                 


<210>  41
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  41

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys 
            20                  25                  30          


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        35                  40                  45              


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
    50                  55                  60                  


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
                85                  90                  95      


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
            100                 105                 110         


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
        115                 120                 125             


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
    130                 135                 140                 


Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
145                 150                 155     


<210>  42
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  42

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Ser 
        35                  40                  45              


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    50                  55                  60                  


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser Gly 
65                  70                  75                  80  


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                85                  90                  95      


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            100                 105                 110         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        115                 120                 125             


Glu Thr His Lys Leu Thr Phe 
    130                 135 


<210>  43
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  43

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
            20                  25                  30          


Val Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
        35                  40                  45              


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
    50                  55                  60                  


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
                85                  90              


<210>  44
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  44

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        35                  40                  45              


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    50                  55                  60                  


Lys Ile Glu Thr His Lys Leu Thr Phe 
65                  70              


<210>  45
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  45

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
            20                  25                  30          


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
        35                  40                  45              


Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
                85                  90          


<210>  46
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  46

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe 
65                  70          


<210>  47
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  47

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
            20                  25                  30          


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
        35                  40                  45              


Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
                85                  90          


<210>  48
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  48

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe 
65                  70          


<210>  49
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  49

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
            20                  25                  30          


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
        35                  40                  45              


Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val 
    50                  55                  60                  


Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly 
65                  70                  75                  80  


Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
                85                  90          


<210>  50
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  50

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        35                  40                  45              


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    50                  55                  60                  


Ile Val Tyr Lys Pro Val Asp Leu 
65                  70          


<210>  51
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  51

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
            20                  25                  30          


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
        35                  40                  45              


Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val 
    50                  55                  60                  


Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly 
65                  70                  75                  80  


Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
                85                  90          


<210>  52
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  52

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Ser 
        35                  40                  45              


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    50                  55                  60                  


Ile Val Tyr Lys Pro Val Asp Leu 
65                  70          


<210>  53
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  53

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
                85                  90          


<210>  54
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  54

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe 
65                  70          


<210>  55
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  55

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                85                  90      


<210>  56
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  56

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe 
65                  70          


<210>  57
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  57

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
                85                  90                  95      


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
            100                 105                 110         


Gly Asn 
        


<210>  58
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  58

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
65                  70                  75                  80  


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
                85                  90                  


<210>  59
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  59

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
                85                  90                  95      


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
            100                 105                 110         


Gly Asn 
        


<210>  60
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  60

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
65                  70                  75                  80  


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
                85                  90                  


<210>  61
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  61

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
            20                  25                  30          


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
        35                  40                  45              


Gly Gly Lys Val Gln Ile Lys Asp Arg Val Gln Ser Lys Ile Gly Ser 
    50                  55                  60                  


Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu 
65                  70                  75                  80  


Thr His Lys Leu Thr Phe 
                85      


<210>  62
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  62

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


Gln Ile Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
        35                  40                  45              


Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu 
    50                  55                  60                  


Thr Phe 
65      


<210>  63
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  63

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn 
            20                  25                  30          


Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly 
        35                  40                  45              


Gly Gly Lys 
    50      


<210>  64
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  64

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30      


<210>  65
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  65

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser 
    50      


<210>  66
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  66

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30      


<210>  67
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  67

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser 
    50      


<210>  68
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  68

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30      


<210>  69
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  69

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
            20                  25                  30          


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
        35                  40                  45              


Gly Gly Gln 
    50      


<210>  70
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  70

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
            20                  25                  30      


<210>  71
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  71

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
            20                  25                  30          


Val Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
        35                  40                  45              


Gly Gly Gln 
    50      


<210>  72
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  72

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
            20                  25                  30      


<210>  73
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  73

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
            20                  25                  30          


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
        35                  40                  45              


Gly Gly Gly Asn 
    50          


<210>  74
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  74

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
1               5                   10                  15      


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
            20                  25                  30          


<210>  75
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  75

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
            20                  25                  30          


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
        35                  40                  45              


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
    50                  55                  60          


<210>  76
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  76

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
1               5                   10                  15      


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
            20                  25                  30          


Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
        35                  40          


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tau 373-378 with N-Terminal Acetylation and C-Terminal Amidation

<400>  77

Thr His Lys Leu Thr Phe 
1               5       


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tau 368-378 with N-Terminal Acetylation and C-Terminal Amidation

<400>  78

Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
1               5                   10      


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tau 354-369

<400>  79

Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Asn Lys 
1               5                   10                  15  


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  80

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
                85                  90                  95      


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
            100                 105                 110         


Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
        115                 120                 


<210>  81
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  81

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
65                  70                  75                  80  


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
                85                  90                  95      


Ile Glu Thr His Lys Leu Thr Phe 
            100                 


<210>  82
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  82

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn 
            20                  25                  30          


Val Gln Ser Lys Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
        35                  40                  45              


Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val 
    50                  55                  60                  


Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
65                  70                  75                  80  


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
                85                  90                  95      


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
            100                 105                 110         


Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
        115                 120                 


<210>  83
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  83

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Ser Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Ser 
        35                  40                  45              


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
    50                  55                  60                  


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
65                  70                  75                  80  


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
                85                  90                  95      


Ile Glu Thr His Lys Leu Thr Phe 
            100                 


<210>  84
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  84

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
            20                  25                  30          


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
        35                  40                  45              


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
    50                  55                  60      


<210>  85
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  85

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe 
        35                  40      


<210>  86
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  86

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
            20                  25                  30          


Val Thr Ser Lys Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
        35                  40                  45              


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
    50                  55                  60      


<210>  87
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  87

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Ser Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe 
        35                  40      


<210>  88
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
            20                  25                  30      


<210>  89
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  89

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30      


<210>  90
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  90

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
            20                  25                  30      


<210>  91
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  91

Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
1               5                   10                  15      


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
            20                  25                  30          


<210>  92
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  92

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
            20                  25                  30          


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
        35                  40                  45              


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
    50                  55                  60                  


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
65                  70                  75                  80  


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
                85                  90              


<210>  93
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant truncated Tau protein

<400>  93

Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys 
1               5                   10                  15      


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        35                  40                  45              


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    50                  55                  60                  


Lys Ile Glu Thr His Lys Leu Thr Phe 
65                  70              


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leader amino acid sequence

<400>  94

Met Gly Ser Ser 
1               


