                         SEQUENCE LISTING

<110>  THE ROCKEFELLER UNIVERSITY
       THE ROCKEFELLER UNIVERSITY
       NUSSENZWEIG, Michel
       FREUND, Natalia T.
       BJORKMAN, Pamela J.
       SCHARF, Louise
 
<120>  BROADLY NEUTRALIZING ANTI-HIV-1 ANTIBODIES AND METHODS OF USE 
       THEREOF

<130>  070413.20322

<140>  PCT/US2017/068235
<141>  2017-12-22

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Val Gln Leu Arg Glu Ser Gly Pro Arg Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Asp Val Phe Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Val His Tyr Asn Gly Asp Asn Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Gly Arg Val Lys Ile Asp Val Asp Arg Ser Thr His Arg Phe Ser 
65                  70                  75                  80  


Leu Thr Leu Lys Ser Leu Thr Ala Ala Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ser Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Pro Gly Thr Ala Val Ile Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Val His Tyr Asn Gly Asp Asn 
1               5           


<210>  4
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Val Ile Arg Val Phe Gly Val Ile Ser Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  5
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Ser Glu Leu Thr Gln Ala Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ala Cys Ser Gly Pro Pro Leu Ala Ser Arg Tyr Thr 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Pro Ser Gly Val Ser Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Lys Ser Gly Thr Thr Ala Thr Leu Thr Ile Arg Asp Val Gln Val Glu 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105             


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Leu Ala Ser Arg Tyr 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  7

Arg Asp Arg 
1           


<210>  8
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Ser Asp Thr Ser Asp Ser Tyr Lys Met 
1               5                   10      


<210>  9
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Thr Val Ser Asn Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Asn Gly Ala Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Arg Ile Glu Leu Asp Gln Ser Ile Pro Arg Phe Ser 
65                  70                  75                  80  


Leu Lys Met Thr Ser Met Thr Ala Ala Asp Thr Gly Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ala Ile Arg Ile Tyr Gly Val Val Ala Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Asn Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  11
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile His Tyr Asn Gly Ala Thr 
1               5           


<210>  12
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  12

Asn Ala Ile Arg Ile Tyr Gly Val Val Ala Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  13
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  13

Ser Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Ala Pro Leu Thr Ser Arg Phe Thr 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Ser 
        35                  40                  45              


Arg Ser Ser Gln Arg Ser Ser Gly Trp Ser Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Trp Ser Gly Thr Thr Val Thr Leu Thr Ile Arg Gly Val Gln Ala Asp 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  14
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  14

Pro Leu Thr Ser Arg Phe 
1               5       


<210>  15
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Ser Ser 
1           


<210>  16
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Ser Asp Thr Ser Asp Ser Tyr Lys Met 
1               5                   10      


<210>  17
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Asp Val Phe Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Val His Tyr Asn Gly Asp Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Gly Arg Val Lys Ile Asp Val Asp Arg Ser Thr His Arg Phe Ser 
65                  70                  75                  80  


Leu Thr Leu Asn Ser Leu Thr Ala Ala Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ser Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Val His Tyr Asn Gly Asp Thr 
1               5           


<210>  20
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  20

Asn Val Ile Arg Val Phe Gly Val Ile Ser Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  21
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  21

Ser Ser Glu Leu Thr Gln Ala Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Ala Cys Ser Gly Pro Pro Leu Ala Ser Arg Tyr Thr 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Pro Ser Gly Val Ser Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Lys Ser Gly Thr Thr Ala Thr Leu Thr Ile Arg Asp Val Gln Val Glu 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105             


<210>  22
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  22

Pro Leu Ala Ser Arg Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Asp Arg 
1           


<210>  24
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Ser Ser Asp Thr Ser Asp Ser Tyr Lys Met 
1               5                   10      


<210>  25
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asn Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Asn Gly Ala Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Arg Ile Glu Leu Asp Gln Ser Ile Pro Arg Phe Ser 
65                  70                  75                  80  


Leu Lys Met Thr Ser Met Thr Ala Ala Asp Thr Gly Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Ala Ile Arg Ile Tyr Gly Val Val Ala Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Asn Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  27
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile His Tyr Asn Gly Ala Thr 
1               5           


<210>  28
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  28

Asn Ala Ile Arg Ile Tyr Gly Val Val Ala Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  29
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  29

Ser Ser Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Lys Ile Thr Cys Ser Gly Ala Ala Leu Thr Ser Arg Phe Thr 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Ser 
        35                  40                  45              


Arg Thr Ser Gln Arg Ser Ser Gly Trp Ser Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Trp Ser Gly Thr Thr Val Thr Leu Thr Ile Arg Gly Val Gln Ala Asp 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  30
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  30

Ala Leu Thr Ser Arg Phe 
1               5       


<210>  31
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Thr Ser 
1           


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Ser Ser Asp Thr Ser Asp Ser Tyr Lys Met 
1               5                   10      


<210>  33
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Asn Met Ala Leu Thr Cys Thr Ile Ser Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Gly Gly Asp Ile Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Lys Leu Glu Val Asp Thr Ser Thr Asn Arg Phe Phe 
65                  70                  75                  80  


Leu Lys Met Thr Ser Leu Thr Val Ala Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Ile Thr Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  35
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  35

Ile His Tyr Gly Gly Asp Ile 
1               5           


<210>  36
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  36

Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  37
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Ser Glu Leu Thr Gln Thr Pro Ser Val Thr Val Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Ser Gly Pro Pro Leu Ala Ser Arg Tyr Cys 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Ser Ser Gly Met Ser Gly Arg Phe Ala Ser Ser 
    50                  55                  60                  


His Ser Gly Thr Thr Val Thr Leu Thr Ile Arg Asp Val Arg Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Ile Asn Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  38
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  38

Pro Leu Ala Ser Arg Tyr 
1               5       


<210>  39
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  39

Arg Asp Arg 
1           


<210>  40
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  40

Gln Ser Ser Asp Ile Asn Asp Ser Tyr Lys Met 
1               5                   10      


<210>  41
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Asn Met Ala Leu Thr Cys Thr Ile Ser Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Ser Pro Gly Lys Thr Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Gly Gly Asp Ile Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Lys Leu Glu Val Asp Thr Ser Ser Asn Arg Phe Phe 
65                  70                  75                  80  


Leu Lys Met Thr Ser Leu Thr Val Ala Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Ile Thr Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  43
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  43

Ile His Tyr Gly Gly Asp Ile 
1               5           


<210>  44
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  45
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Ser Glu Leu Thr Gln Thr Ala Ser Val Thr Val Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Ser Gly Pro Pro Leu Ala Ser Arg Tyr Cys 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Ser Ser Gly Ile Ser Gly Arg Phe Ser Ser Ser 
    50                  55                  60                  


Gln Ser Gly Thr Thr Val Thr Leu Thr Ile Arg Asp Val Arg Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Phe 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  46
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  46

Pro Leu Ala Ser Arg Tyr 
1               5       


<210>  47
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  47

Arg Asp Arg 
1           


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Ser Ser Asp Thr Ser Asp Ser Phe Lys Met 
1               5                   10      


<210>  49
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Asn Met Ala Leu Thr Cys Thr Ile Ser Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Gly Gly Asp Ile Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Glu Leu Glu Val Asp Arg Ser Thr Asn Arg Phe Phe 
65                  70                  75                  80  


Leu Lys Met Thr Ser Leu Ser Val Ala Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Ile Thr Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  51
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  51

Ile His Tyr Gly Gly Asp Ile 
1               5           


<210>  52
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  52

Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  53
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Ser Glu Leu Thr Gln Ala Pro Ser Val Thr Val Ser Pro Gly Asp 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Ser Gly Pro Pro Leu Ala Thr Arg Tyr Cys 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Ser Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Ser Ser Gly Val Ser Gly Arg Phe Ser Ser Ser 
    50                  55                  60                  


Gln Ser Gly Ser Thr Val Thr Leu Thr Ile Arg Asp Val Arg Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  54
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  54

Pro Leu Ala Thr Arg Tyr 
1               5       


<210>  55
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  55

Arg Asp Arg 
1           


<210>  56
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  56

Gln Ser Ser Asp Thr Ser Asp Ser Tyr Lys Met 
1               5                   10      


<210>  57
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  57

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Asp Val Phe Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Asn Gly Asp Lys Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Gly Arg Val Lys Ile Asp Val Asp Arg Ser Thr His Arg Phe Ser 
65                  70                  75                  80  


Leu Thr Leu Asn Ser Leu Thr Ala Ala Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ser Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Pro Gly Thr Ala Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  58
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  59
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  59

Ile His Tyr Asn Gly Asp Lys 
1               5           


<210>  60
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  60

Asn Val Ile Arg Val Phe Gly Val Ile Ser Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  61
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Ser Glu Leu Thr Gln Ala Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Ser Gly Pro Pro Leu Ala Ser Arg Tyr Thr 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Pro Ser Gly Val Ser Gly Arg Phe Ser Ala Ser 
    50                  55                  60                  


Lys Ser Gly Thr Thr Gly Thr Leu Thr Ile Arg Asp Val Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Gly Asp Tyr Tyr Cys Gln Ser Ser Asp Thr Ser Asp Ser Tyr 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105             


<210>  62
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  62

Pro Leu Ala Ser Arg Tyr 
1               5       


<210>  63
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  63

Arg Asp Arg 
1           


<210>  64
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln Ser Ser Asp Thr Ser Asp Ser Tyr Lys Met 
1               5                   10      


<210>  65
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  65

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Asn Met Ala Leu Thr Cys Thr Ile Ser Gly Asp Ser Arg Pro Ser Asp 
            20                  25                  30          


His Ser Trp Thr Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp 
        35                  40                  45              


Ile Gly Asp Ile His Tyr Gly Gly Asp Ile Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Val Lys Leu Glu Val Asp Thr Ser Ser Asn Arg Phe Phe 
65                  70                  75                  80  


Leu Lys Met Thr Ser Leu Thr Val Ala Asp Thr Gly Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp 
            100                 105                 110         


Phe His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Ala Ile Thr Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  66
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Asp Ser Arg Pro Ser Asp His Ser 
1               5                   


<210>  67
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  67

Ile His Tyr Gly Gly Asp Ile 
1               5           


<210>  68
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  68

Asn Val Ile Arg Val Phe Gly Val Ile Ala Leu Gly Glu Trp Phe His 
1               5                   10                  15      


Tyr Gly Met Asp Val 
            20      


<210>  69
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  69

Ser Ser Glu Leu Thr Gln Ala Pro Ser Val Thr Leu Ser Pro Gly Glu 
1               5                   10                  15      


Thr Ala Arg Ile Ala Cys Ser Gly Pro Pro Leu Ala Ser Arg Tyr Cys 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Val Leu Ile Ile Phe 
        35                  40                  45              


Arg Asp Arg Gln Phe Ser Ser Gly Ile Ser Gly Arg Phe Ser Ser Ser 
    50                  55                  60                  


Gln Ser Gly Thr Thr Val Thr Leu Thr Ile Arg Asp Val Arg Val Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Asn Ser Asp Ser Phe 
                85                  90                  95      


Lys Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  70
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  70

Pro Leu Ala Ser Arg Tyr 
1               5       


<210>  71
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  71

Arg Asp Arg 
1           


<210>  72
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  72

Gln Ser Ser Asp Asn Ser Asp Ser Phe Lys Met 
1               5                   10      


<210>  73
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Tyr Phe Pro Asp Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Val 
        35                  40                  45              


Gly Phe Met Arg Gly Trp Ala Tyr Gly Gly Ser Ala Gln Phe Ala Ala 
    50                  55                  60                  


Phe Ala Val Gly Lys Phe Ala Ile Ser Arg Asp Asp Gly Arg Asn Val 
65                  70                  75                  80  


Val Tyr Leu Asp Val Lys Asn Pro Thr Phe Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Gln Arg Asn Lys Asp Tyr Arg Tyr Gly Gln Glu 
            100                 105                 110         


Gly Phe Gly Tyr Ser Tyr Gly Met Asp Val Trp Gly Arg Gly Thr Thr 
        115                 120                 125             


Val Val Val Ser Thr 
    130             


<210>  74
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  74

Gly Phe Tyr Phe Pro Asp Tyr Ala 
1               5               


<210>  75
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Arg Gly Trp Ala Tyr Gly Gly Ser Ala 
1               5                   10  


<210>  76
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  76

Glu Gln Arg Asn Lys Asp Tyr Arg Tyr Gly Gln Glu Gly Phe Gly Tyr 
1               5                   10                  15      


Ser Tyr Gly Met Asp Val 
            20          


<210>  77
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  77

Asp Ile His Met Thr Gln Ser Pro Val Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Asn Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Leu Leu Ile 
        35                  40                  45              


Phe Glu Ser Ser Thr Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Tyr Gly Asp Gly Thr Glu Phe Thr Leu Ser Ile Asn Thr Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Ile Cys Gln Gln Ser His Ser Pro Pro Val 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Arg Val Asp Gln Lys 
            100                 105         


<210>  78
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  78

His Phe Ile Ala Asn Tyr 
1               5       


<210>  79
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  79

Glu Ser Ser 
1           


<210>  80
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  80

Gln Gln Ser His Ser Pro Pro Val Thr 
1               5                   


<210>  81
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Glu Arg Leu Val Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Phe Asp Phe Tyr Phe Pro Asp Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Gly Trp Ala Tyr Gly Gln Ala Ala Gln Tyr Gly Lys 
    50                  55                  60                  


Ser Ala Ser Gly Arg Met Thr Ile Ser Arg Asp Asp Ser Arg Arg Val 
65                  70                  75                  80  


Val Tyr Leu Asp Ile Lys Ser Pro Ile Glu Glu Asp Thr Gly Ala Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Gln Arg Gly Gly Asp Gly Arg Tyr Ser Gly Asp 
            100                 105                 110         


Gly Phe Gly Tyr Pro Tyr Gly Met Asp Val Trp Gly Arg Gly Thr Met 
        115                 120                 125             


Val Thr Val Ser Ala 
    130             


<210>  82
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  82

Asp Phe Tyr Phe Pro Asp Tyr Ala 
1               5               


<210>  83
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  83

Ile Arg Gly Trp Ala Tyr Gly Gln Ala Ala 
1               5                   10  


<210>  84
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Gln Arg Gly Gly Asp Gly Arg Tyr Ser Gly Asp Gly Phe Gly Tyr 
1               5                   10                  15      


Pro Tyr Gly Met Asp Val 
            20          


<210>  85
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  85

Asp Ile Leu Met Thr Gln Ser Pro Val Ser Leu Ser Ala Ser Ile Gly 
1               5                   10                  15      


Glu Arg Ile Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Asn Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Gln Ser Trp Thr Leu Asn Arg Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Tyr Gly Asp Gly Thr Glu Phe Thr Leu Ser Ile Ser Ala Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Ile Cys Gln Gln Ser His Ser Pro Pro Leu 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Arg Val Asp Gln Thr 
            100                 105         


<210>  86
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  86

His Phe Ile Ala Asn Tyr 
1               5       


<210>  87
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  87

Gln Ser Trp 
1           


<210>  88
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  88

Gln Gln Ser His Ser Pro Pro Leu Ser 
1               5                   


<210>  89
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  89

Glu Glu Arg Leu Val Glu Ser Gly Gly Gly Leu Val Pro Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Phe Asp Phe Tyr Phe Pro Asp Tyr 
            20                  25                  30          


Ala Met Ala Trp Val Arg Gln Ala Pro Gly Arg Ala Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Arg Gly Trp Ala Tyr Gly Gln Ser Ala Gln Tyr Gly Lys 
    50                  55                  60                  


Ser Ala Ser Gly Arg Met Thr Ile Ser Arg Asp Asp Ser Arg Arg Val 
65                  70                  75                  80  


Val Tyr Leu Asp Ile Lys Ser Pro Thr His Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Glu Gln Arg Gly Ala Asn Gly Arg Tyr Gly Gly Asp 
            100                 105                 110         


Gly Phe Gly Tyr Ser Tyr Gly Met Asp Val Trp Gly Arg Gly Thr Met 
        115                 120                 125             


Val Ser Val Ser Ala 
    130             


<210>  90
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  90

Asp Phe Tyr Phe Pro Asp Tyr Ala 
1               5               


<210>  91
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  91

Ile Arg Gly Trp Ala Tyr Gly Gln Ser Ala 
1               5                   10  


<210>  92
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  92

Glu Gln Arg Gly Ala Asn Gly Arg Tyr Gly Gly Asp Gly Phe Gly Tyr 
1               5                   10                  15      


Ser Tyr Gly Met Asp Val 
            20          


<210>  93
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Phe Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Asn Tyr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Arg Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Glu Ser Ser Thr Leu Asn Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Asp Gly Thr Glu Phe Thr Leu Ser Ile Ser Ala Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Ile Cys Gln Gln Ser His Ser Pro Pro Val 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Arg Val Asp Gln Thr 
            100                 105         


<210>  94
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  94

His Phe Ile Ala Asn Tyr 
1               5       


<210>  95
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  95

Glu Ser Ser 
1           


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  96

Gln Gln Ser His Ser Pro Pro Val Ser 
1               5                   


