                         SEQUENCE LISTING

<110>  Henriques Normark, Birgitta
 
<120>  MICROPARTICLES FROM STREPTOCOCCUS PNEUMONIAE AS VACCINE ANTIGENS

<130>  NP0263WO

<150>  SE 1651746-8
<151>  2016-12-28

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  471
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  1

Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      


Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          


Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              


Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  


Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      


Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         


Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             


Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 


Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 


Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     


Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         


Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             


Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 


Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     


Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         


Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             


Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 


Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 


Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     


Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         


Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             


Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 


Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 


Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     


Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         


Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             


Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 


Glu Asp Lys Val Glu Asn Asp 
465                 470     


<210>  2
<211>  318
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  2

Met Glu Ile Asn Val Ser Lys Leu Arg Thr Asp Leu Pro Gln Val Gly 
1               5                   10                  15      


Val Gln Pro Tyr Arg Gln Val His Ala His Ser Thr Gly Asn Pro His 
            20                  25                  30          


Ser Thr Val Gln Asn Glu Ala Asp Tyr His Trp Arg Lys Asp Pro Glu 
        35                  40                  45              


Leu Gly Phe Phe Ser His Ile Val Gly Asn Gly Cys Ile Met Gln Val 
    50                  55                  60                  


Gly Pro Val Asp Asn Gly Ala Trp Asp Val Gly Gly Gly Trp Asn Ala 
65                  70                  75                  80  


Glu Thr Tyr Ala Ala Val Glu Leu Ile Glu Ser His Ser Thr Lys Glu 
                85                  90                  95      


Glu Phe Met Thr Asp Tyr Arg Leu Tyr Ile Glu Leu Leu Arg Asn Leu 
            100                 105                 110         


Ala Asp Glu Ala Gly Leu Pro Lys Thr Leu Asp Thr Gly Ser Leu Ala 
        115                 120                 125             


Gly Ile Lys Thr His Glu Tyr Cys Thr Asn Asn Gln Pro Asn Asn His 
    130                 135                 140                 


Ser Asp His Val Asp Pro Tyr Pro Tyr Leu Ala Lys Trp Gly Ile Ser 
145                 150                 155                 160 


Arg Glu Gln Phe Lys His Asp Ile Glu Asn Gly Leu Thr Ile Glu Thr 
                165                 170                 175     


Gly Trp Gln Lys Asn Asp Thr Gly Tyr Trp Tyr Val His Ser Asp Gly 
            180                 185                 190         


Ser Tyr Pro Lys Asp Lys Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr 
        195                 200                 205             


Phe Asp Ser Ser Gly Tyr Met Leu Ala Asp Arg Trp Arg Lys His Thr 
    210                 215                 220                 


Asp Gly Asn Trp Tyr Trp Phe Asp Asn Ser Gly Glu Met Ala Thr Gly 
225                 230                 235                 240 


Trp Lys Lys Ile Ala Asp Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala 
                245                 250                 255     


Met Lys Thr Gly Trp Val Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp 
            260                 265                 270         


Ala Lys Glu Gly Ala Met Val Ser Asn Ala Phe Ile Gln Ser Ala Asp 
        275                 280                 285             


Gly Thr Gly Trp Tyr Tyr Leu Lys Pro Asp Gly Thr Leu Ala Asp Lys 
    290                 295                 300                 


Pro Glu Phe Thr Val Glu Pro Asp Gly Leu Ile Thr Val Lys 
305                 310                 315             


<210>  3
<211>  929
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  3

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Phe Leu Gly 
            20                  25                  30          


Gly Val Val His Ala Glu Gly Val Arg Ser Gly Asn Asn Leu Thr Val 
        35                  40                  45              


Thr Ser Ser Gly Gln Asp Ile Ser Lys Lys Tyr Ala Asp Glu Val Glu 
    50                  55                  60                  


Ser His Leu Glu Ser Ile Leu Lys Asp Val Lys Lys Asn Leu Lys Lys 
65                  70                  75                  80  


Val Gln His Thr Gln Asn Val Gly Leu Ile Thr Lys Leu Ser Glu Ile 
                85                  90                  95      


Lys Lys Lys Tyr Leu Tyr Asp Leu Lys Val Asn Val Leu Ser Glu Ala 
            100                 105                 110         


Glu Leu Thr Ser Lys Thr Lys Glu Thr Lys Glu Lys Leu Thr Ala Thr 
        115                 120                 125             


Phe Glu Gln Phe Lys Lys Asp Thr Leu Pro Thr Glu Pro Glu Lys Lys 
    130                 135                 140                 


Val Ala Glu Ala Gln Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu 
145                 150                 155                 160 


Asp Gln Lys Glu Lys Asp Arg Arg Asn Tyr Pro Thr Ile Thr Tyr Lys 
                165                 170                 175     


Thr Leu Glu Leu Glu Ile Ala Glu Ser Asp Val Glu Val Lys Lys Ala 
            180                 185                 190         


Glu Leu Glu Leu Val Lys Val Lys Ala Lys Glu Ser Gln Asp Glu Glu 
        195                 200                 205             


Lys Ile Lys Gln Ala Glu Ala Glu Val Glu Ser Lys Gln Ala Glu Ala 
    210                 215                 220                 


Thr Arg Leu Lys Lys Ile Lys Thr Asp Arg Glu Glu Ala Lys Arg Lys 
225                 230                 235                 240 


Ala Asp Ala Lys Leu Lys Glu Ala Val Glu Lys Asn Val Ala Thr Ser 
                245                 250                 255     


Glu Gln Asp Lys Pro Lys Arg Arg Ala Lys Arg Gly Val Ser Gly Glu 
            260                 265                 270         


Leu Ala Thr Pro Asp Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser 
        275                 280                 285             


Ser Val Gly Glu Glu Thr Leu Pro Ser Pro Ser Leu Asn Met Ala Asn 
    290                 295                 300                 


Glu Ser Gln Thr Glu His Arg Lys Asp Val Asp Glu Tyr Ile Lys Lys 
305                 310                 315                 320 


Met Leu Ser Glu Ile Gln Leu Asp Arg Arg Lys His Thr Gln Asn Val 
                325                 330                 335     


Asn Leu Asn Ile Lys Leu Ser Ala Ile Lys Thr Lys Tyr Leu Tyr Glu 
            340                 345                 350         


Leu Ser Val Leu Lys Glu Asn Ser Lys Lys Glu Glu Leu Thr Ser Lys 
        355                 360                 365             


Thr Lys Ala Glu Leu Thr Ala Ala Phe Glu Gln Phe Lys Lys Asp Thr 
    370                 375                 380                 


Leu Lys Pro Glu Lys Lys Val Ala Glu Ala Glu Lys Lys Val Glu Glu 
385                 390                 395                 400 


Ala Lys Lys Lys Ala Lys Asp Gln Lys Glu Glu Asp Arg Arg Asn Tyr 
                405                 410                 415     


Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu Glu Ile Ala Glu Ser Asp 
            420                 425                 430         


Val Lys Val Lys Glu Ala Glu Leu Glu Leu Val Lys Glu Glu Ala Asn 
        435                 440                 445             


Glu Ser Arg Asn Glu Glu Lys Ile Lys Gln Ala Lys Glu Lys Val Glu 
    450                 455                 460                 


Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu Lys Ile Lys Thr Asp Arg 
465                 470                 475                 480 


Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys Ala Glu Glu Ser Glu Lys 
                485                 490                 495     


Lys Ala Ala Glu Ala Lys Gln Lys Val Asp Ala Glu Glu Tyr Ala Leu 
            500                 505                 510         


Glu Ala Lys Ile Ala Glu Leu Glu Tyr Glu Val Gln Arg Leu Glu Lys 
        515                 520                 525             


Glu Leu Lys Glu Ile Asp Glu Ser Asp Ser Glu Asp Tyr Leu Lys Glu 
    530                 535                 540                 


Gly Leu Arg Ala Pro Leu Gln Ser Lys Leu Asp Thr Lys Lys Ala Lys 
545                 550                 555                 560 


Leu Ser Lys Leu Glu Glu Leu Ser Asp Lys Ile Asp Glu Leu Asp Ala 
                565                 570                 575     


Glu Ile Ala Lys Leu Glu Val Gln Leu Lys Asp Ala Glu Gly Asn Asn 
            580                 585                 590         


Asn Val Glu Ala Tyr Phe Lys Glu Gly Leu Glu Lys Thr Thr Ala Glu 
        595                 600                 605             


Lys Lys Ala Glu Leu Glu Lys Ala Glu Ala Asp Leu Lys Lys Ala Val 
    610                 615                 620                 


Asp Glu Pro Glu Thr Pro Ala Pro Ala Pro Gln Pro Ala Pro Ala Pro 
625                 630                 635                 640 


Glu Lys Pro Ala Glu Lys Pro Ala Pro Ala Pro Glu Lys Pro Ala Pro 
                645                 650                 655     


Ala Pro Glu Lys Pro Ala Pro Ala Pro Glu Lys Pro Ala Pro Ala Pro 
            660                 665                 670         


Glu Lys Pro Ala Pro Ala Pro Glu Lys Pro Ala Pro Thr Pro Glu Thr 
        675                 680                 685             


Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
    690                 695                 700                 


Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
705                 710                 715                 720 


Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
                725                 730                 735     


Asn Gly Ser Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly 
            740                 745                 750         


Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp 
        755                 760                 765             


Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
    770                 775                 780                 


Ala Asn Gly Asp Met Ala Thr Gly Trp Phe Gln Tyr Asn Gly Ser Trp 
785                 790                 795                 800 


Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Phe Gln Tyr 
                805                 810                 815     


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly 
            820                 825                 830         


Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ser Asn Gly Ala 
        835                 840                 845             


Met Val Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn 
    850                 855                 860                 


Ala Asn Gly Ser Met Ala Thr Asp Trp Val Lys Asp Gly Asp Thr Trp 
865                 870                 875                 880 


Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys 
                885                 890                 895     


Val Ser Asp Asn Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu Ala Val 
            900                 905                 910         


Asn Thr Thr Val Asp Ser Tyr Arg Val Asn Pro Asn Gly Glu Trp Val 
        915                 920                 925             


Asn 
    


<210>  4
<211>  579
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  4

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Val Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Ser Thr Gln Ala Ala Thr 
        35                  40                  45              


Phe Ser Asn Met Ala Asn Lys Ser Gln Thr Glu Gln Gly Glu Ile Asn 
    50                  55                  60                  


Ile Glu Arg Asp Lys Ala Lys Thr Ala Val Ser Glu Tyr Lys Glu Lys 
65                  70                  75                  80  


Lys Val Ser Glu Ile Tyr Thr Lys Leu Glu Arg Asp Arg His Lys Asp 
                85                  90                  95      


Thr Val Asp Leu Val Asn Lys Leu Gln Glu Ile Lys Asn Glu Tyr Leu 
            100                 105                 110         


Asn Lys Ile Val Gln Ser Thr Ser Lys Thr Glu Ile Gln Gly Leu Ile 
        115                 120                 125             


Thr Thr Ser Arg Ser Lys Leu Asp Glu Ala Val Ser Lys Tyr Lys Lys 
    130                 135                 140                 


Ala Pro Ser Ser Ser Ser Ser Ser Gly Ser Ser Thr Lys Pro Glu Ala 
145                 150                 155                 160 


Ser Asp Thr Ala Lys Pro Asn Lys Pro Thr Glu Leu Glu Lys Lys Val 
                165                 170                 175     


Ala Glu Ala Glu Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Lys Asp 
            180                 185                 190         


Gln Lys Glu Glu Asp Tyr Arg Asn Tyr Pro Thr Ile Thr Tyr Lys Thr 
        195                 200                 205             


Leu Glu Leu Glu Ile Ala Glu Ser Asp Val Glu Val Lys Lys Ala Glu 
    210                 215                 220                 


Leu Glu Leu Val Lys Glu Glu Ala Lys Glu Pro Arg Asn Glu Glu Lys 
225                 230                 235                 240 


Val Lys Gln Ala Lys Ala Lys Val Glu Ser Glu Glu Thr Glu Ala Thr 
                245                 250                 255     


Arg Leu Glu Lys Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala 
            260                 265                 270         


Lys Arg Lys Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu 
        275                 280                 285             


Gln Pro Lys Pro Ala Pro Ala Pro Gln Pro Glu Lys Pro Ala Pro Lys 
    290                 295                 300                 


Pro Glu Asn Pro Ala Pro Lys Pro Glu Asn Pro Ala Pro Lys Pro Glu 
305                 310                 315                 320 


Lys Pro Ala Glu Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu 
                325                 330                 335     


Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys 
            340                 345                 350         


Pro Ala Gln Pro Ser Thr Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly 
        355                 360                 365             


Met Trp Tyr Phe Tyr Asn Thr Asp Gly Ser Met Ala Thr Gly Trp Leu 
    370                 375                 380                 


Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala 
385                 390                 395                 400 


Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn 
                405                 410                 415     


Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr 
            420                 425                 430         


Leu Asn Ala Asn Gly Ser Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly 
        435                 440                 445             


Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu 
    450                 455                 460                 


Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala 
465                 470                 475                 480 


Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn 
                485                 490                 495     


Gly Asp Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr 
            500                 505                 510         


Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Val Lys Asp Gly Asp 
        515                 520                 525             


Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala Ser Gln Trp 
    530                 535                 540                 


Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu 
545                 550                 555                 560 


Ala Val Asn Thr Thr Val Asp Gly Tyr Gly Val Asn Ala Asn Gly Glu 
                565                 570                 575     


Trp Val Asn 
            


<210>  5
<211>  693
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  5

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Val Gly Val Ala Ser Val Val Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Ala Thr Gln Val Pro Thr 
        35                  40                  45              


Ser Ser Asn Arg Ala Asn Glu Ser Gln Ala Glu Gln Gly Glu Gln Pro 
    50                  55                  60                  


Lys Lys Leu Asp Ser Glu Arg Asp Lys Ala Arg Lys Glu Val Glu Glu 
65                  70                  75                  80  


Tyr Val Lys Lys Ile Val Gly Glu Ser Tyr Ala Lys Ser Thr Lys Lys 
                85                  90                  95      


Arg His Thr Ile Thr Val Ala Leu Val Asn Glu Leu Asn Asn Ile Lys 
            100                 105                 110         


Asn Glu Tyr Leu Asn Lys Ile Val Glu Ser Thr Ser Glu Ser Gln Leu 
        115                 120                 125             


Gln Ile Leu Met Met Glu Ser Arg Ser Lys Val Asp Glu Ala Val Ser 
    130                 135                 140                 


Lys Phe Glu Lys Asp Ser Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr 
145                 150                 155                 160 


Lys Pro Glu Ala Ser Asp Thr Ala Lys Pro Asn Lys Pro Thr Glu Pro 
                165                 170                 175     


Gly Glu Lys Val Ala Glu Ala Lys Lys Lys Val Glu Glu Ala Glu Lys 
            180                 185                 190         


Lys Ala Lys Asp Gln Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Ile 
        195                 200                 205             


Thr Tyr Lys Thr Leu Glu Leu Glu Ile Ala Glu Ser Asp Val Glu Val 
    210                 215                 220                 


Lys Lys Ala Glu Leu Glu Leu Val Lys Val Lys Ala Asn Glu Pro Arg 
225                 230                 235                 240 


Asp Glu Gln Lys Ile Lys Gln Ala Glu Ala Glu Val Glu Ser Lys Gln 
                245                 250                 255     


Ala Glu Ala Thr Arg Leu Lys Lys Ile Lys Thr Asp Arg Glu Glu Ala 
            260                 265                 270         


Glu Glu Glu Ala Lys Arg Arg Ala Asp Ala Lys Glu Gln Gly Lys Pro 
        275                 280                 285             


Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr Pro Asp 
    290                 295                 300                 


Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly Glu Glu 
305                 310                 315                 320 


Thr Leu Pro Ser Pro Ser Leu Lys Pro Glu Lys Lys Val Ala Glu Ala 
                325                 330                 335     


Glu Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
            340                 345                 350         


Glu Asp Arg Arg Asn Tyr Pro Thr Ile Thr Tyr Lys Thr Leu Glu Leu 
        355                 360                 365             


Glu Ile Ala Glu Ser Asp Val Glu Val Lys Lys Ala Glu Leu Glu Leu 
    370                 375                 380                 


Val Lys Glu Glu Ala Lys Glu Pro Arg Asn Glu Glu Lys Val Lys Gln 
385                 390                 395                 400 


Ala Lys Ala Glu Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
                405                 410                 415     


Lys Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
            420                 425                 430         


Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln Pro Gln 
        435                 440                 445             


Pro Ala Pro Ala Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Lys Pro 
    450                 455                 460                 


Glu Asn Pro Ala Glu Gln Pro Lys Ala Glu Lys Pro Ala Asp Gln Gln 
465                 470                 475                 480 


Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
                485                 490                 495     


Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
            500                 505                 510         


Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
        515                 520                 525             


Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
    530                 535                 540                 


Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
545                 550                 555                 560 


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
                565                 570                 575     


Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser 
            580                 585                 590         


Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
        595                 600                 605             


Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
    610                 615                 620                 


Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Val Lys Asp 
625                 630                 635                 640 


Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala Ser 
                645                 650                 655     


Gln Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val Asn Gly Ser Gly 
            660                 665                 670         


Ala Leu Ala Val Asn Thr Thr Val Asp Gly Tyr Gly Val Asn Ala Asn 
        675                 680                 685             


Gly Glu Trp Val Asn 
    690             


<210>  6
<211>  701
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  6

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Ser Thr Gln Ala Ala Thr 
        35                  40                  45              


Ser Ser Asn Met Ala Lys Thr Glu His Arg Lys Ala Ala Lys Gln Val 
    50                  55                  60                  


Val Asp Glu Tyr Ile Glu Lys Met Leu Arg Glu Ile Gln Leu Asp Arg 
65                  70                  75                  80  


Arg Lys His Thr Gln Asn Val Ala Leu Asn Ile Lys Leu Ser Ala Ile 
                85                  90                  95      


Lys Thr Lys Tyr Leu Arg Glu Leu Asn Val Leu Glu Glu Lys Ser Lys 
            100                 105                 110         


Asp Glu Leu Pro Ser Glu Ile Lys Ala Lys Leu Asp Ala Ala Phe Glu 
        115                 120                 125             


Lys Phe Lys Lys Asp Thr Leu Lys Pro Gly Glu Lys Val Ala Glu Ala 
    130                 135                 140                 


Lys Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
145                 150                 155                 160 


Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 
                165                 170                 175     


Glu Ile Ala Glu Phe Asp Val Lys Val Lys Glu Ala Glu Leu Glu Leu 
            180                 185                 190         


Val Lys Glu Glu Ala Lys Glu Ser Arg Asn Glu Gly Thr Ile Lys Gln 
        195                 200                 205             


Ala Lys Glu Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
    210                 215                 220                 


Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
225                 230                 235                 240 


Ala Asp Ala Lys Leu Lys Glu Ala Asn Val Ala Thr Ser Asp Gln Gly 
                245                 250                 255     


Lys Pro Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr 
            260                 265                 270         


Pro Asp Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly 
        275                 280                 285             


Glu Glu Thr Leu Pro Ser Ser Ser Leu Lys Ser Gly Lys Lys Val Ala 
    290                 295                 300                 


Glu Ala Glu Lys Lys Val Glu Glu Ala Glu Lys Lys Ala Lys Asp Gln 
305                 310                 315                 320 


Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu 
                325                 330                 335     


Asp Leu Glu Ile Ala Glu Ser Asp Val Lys Val Lys Glu Ala Glu Leu 
            340                 345                 350         


Glu Leu Val Lys Glu Glu Ala Lys Glu Pro Arg Asp Glu Glu Lys Ile 
        355                 360                 365             


Lys Gln Ala Lys Ala Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg 
    370                 375                 380                 


Leu Glu Asn Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys 
385                 390                 395                 400 


Arg Lys Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln 
                405                 410                 415     


Pro Gln Pro Ala Pro Ala Thr Gln Pro Glu Lys Pro Ala Pro Lys Pro 
            420                 425                 430         


Glu Lys Pro Ala Glu Gln Pro Lys Ala Glu Lys Thr Asp Asp Gln Gln 
        435                 440                 445             


Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
    450                 455                 460                 


Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
465                 470                 475                 480 


Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
                485                 490                 495     


Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
            500                 505                 510         


Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
        515                 520                 525             


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
    530                 535                 540                 


Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala 
545                 550                 555                 560 


Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
                565                 570                 575     


Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
            580                 585                 590         


Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln Asn 
        595                 600                 605             


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly 
    610                 615                 620                 


Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp 
625                 630                 635                 640 


Met Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu 
                645                 650                 655     


Ala Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys 
            660                 665                 670         


Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu Ala Val Asn Thr Thr Val 
        675                 680                 685             


Asp Gly Tyr Gly Val Asn Ala Asn Gly Glu Trp Val Asn 
    690                 695                 700     


<210>  7
<211>  693
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  7

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Val Gly Val Ala Ser Val Val Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Ala Thr Gln Val Pro Thr 
        35                  40                  45              


Ser Ser Asn Arg Ala Asn Glu Ser Gln Ala Glu Gln Gly Glu Gln Pro 
    50                  55                  60                  


Lys Lys Leu Asp Ser Glu Arg Asp Lys Ala Arg Lys Glu Val Glu Glu 
65                  70                  75                  80  


Tyr Val Lys Lys Ile Val Gly Glu Ser Tyr Ala Lys Ser Thr Lys Lys 
                85                  90                  95      


Arg His Thr Ile Thr Val Ala Leu Val Asn Glu Leu Asn Asn Ile Lys 
            100                 105                 110         


Asn Glu Tyr Leu Asn Lys Ile Val Glu Ser Thr Ser Glu Ser Gln Leu 
        115                 120                 125             


Gln Ile Leu Met Met Glu Ser Arg Ser Lys Val Asp Glu Ala Val Ser 
    130                 135                 140                 


Lys Phe Glu Lys Asp Ser Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr 
145                 150                 155                 160 


Lys Pro Glu Ala Ser Asp Thr Ala Lys Pro Asn Lys Pro Thr Glu Pro 
                165                 170                 175     


Gly Glu Lys Val Ala Glu Ala Lys Lys Lys Val Glu Glu Ala Glu Lys 
            180                 185                 190         


Lys Ala Lys Asp Gln Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Ile 
        195                 200                 205             


Thr Tyr Lys Thr Leu Glu Leu Glu Ile Ala Glu Ser Asp Val Glu Val 
    210                 215                 220                 


Lys Lys Ala Glu Leu Glu Leu Val Lys Val Lys Ala Asn Glu Pro Arg 
225                 230                 235                 240 


Asp Glu Gln Lys Ile Lys Gln Ala Glu Ala Glu Val Glu Ser Lys Gln 
                245                 250                 255     


Ala Glu Ala Thr Arg Leu Lys Lys Ile Lys Thr Asp Arg Glu Glu Ala 
            260                 265                 270         


Glu Glu Glu Ala Lys Arg Arg Ala Asp Ala Lys Glu Gln Gly Lys Pro 
        275                 280                 285             


Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr Pro Asp 
    290                 295                 300                 


Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly Glu Glu 
305                 310                 315                 320 


Thr Leu Pro Ser Pro Ser Leu Lys Pro Glu Lys Lys Val Ala Glu Ala 
                325                 330                 335     


Glu Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
            340                 345                 350         


Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 
        355                 360                 365             


Glu Ile Ala Glu Ser Asp Val Glu Val Lys Lys Ala Glu Leu Glu Leu 
    370                 375                 380                 


Val Lys Glu Glu Ala Lys Glu Pro Arg Asn Glu Glu Lys Val Lys Gln 
385                 390                 395                 400 


Ala Lys Ala Glu Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
                405                 410                 415     


Lys Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
            420                 425                 430         


Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln Pro Gln 
        435                 440                 445             


Pro Ala Pro Ala Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Lys Pro 
    450                 455                 460                 


Glu Asn Pro Ala Glu Gln Pro Lys Ala Glu Lys Pro Ala Asp Gln Gln 
465                 470                 475                 480 


Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
                485                 490                 495     


Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
            500                 505                 510         


Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
        515                 520                 525             


Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
    530                 535                 540                 


Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
545                 550                 555                 560 


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
                565                 570                 575     


Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser 
            580                 585                 590         


Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
        595                 600                 605             


Ala Asn Gly Ser Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
    610                 615                 620                 


Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Val Lys Asp 
625                 630                 635                 640 


Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala Ser 
                645                 650                 655     


Gln Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val Asn Gly Ser Gly 
            660                 665                 670         


Ala Leu Ala Val Asn Thr Thr Val Asp Gly Tyr Gly Val Asn Ala Asn 
        675                 680                 685             


Gly Glu Trp Val Asn 
    690             


<210>  8
<211>  866
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  8

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Val Val Ala Ser Leu Phe Leu Gly 
            20                  25                  30          


Gly Val Val His Ala Glu Glu Val Arg Arg Gly Asn Asn Leu Thr Val 
        35                  40                  45              


Thr Ser Ser Gly Asp Glu Val Glu Ser His Tyr Gln Ser Ile Leu Glu 
    50                  55                  60                  


Lys Val Arg Lys Ser Leu Glu Lys Asp Arg His Thr Gln Asn Val Asp 
65                  70                  75                  80  


Leu Ile Lys Lys Leu Gln Asp Ile Lys Arg Thr Tyr Leu Tyr Asn Leu 
                85                  90                  95      


Lys Glu Lys Pro Glu Ala Glu Leu Thr Ser Lys Thr Lys Lys Glu Leu 
            100                 105                 110         


Asp Ala Ala Phe Glu Lys Phe Lys Lys Glu Pro Glu Leu Thr Lys Lys 
        115                 120                 125             


Leu Ala Glu Ala Glu Lys Lys Ala Lys Asp Gln Lys Glu Glu Asp His 
    130                 135                 140                 


Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Ile Glu Leu Glu Ile Ala 
145                 150                 155                 160 


Glu Ala Glu Val Gly Val Ala Lys Ala Glu Leu Glu Leu Ala Gln Ala 
                165                 170                 175     


Gln Val Gln Ile Pro Gln Asp Thr Glu Lys Ile Asn Ala Ala Lys Ala 
            180                 185                 190         


Lys Val Glu Ala Ala Lys Ser Asn Val Lys Lys Leu Glu Lys Ile Lys 
        195                 200                 205             


Ser Asp Ile Glu Lys Thr Tyr Leu Tyr Lys Leu Asp Asn Ser Thr Lys 
    210                 215                 220                 


Glu Thr Pro Lys Pro Arg Val Arg Arg Asn Ser Pro Glu Ile Lys Ala 
225                 230                 235                 240 


Lys Gly Arg Val Lys Asn Tyr Lys Glu Ala Asn Ile Glu Leu Ser Lys 
                245                 250                 255     


Tyr Met Thr Asp Leu Tyr Lys Leu Asp Asn Ser Thr Lys Glu Thr Pro 
            260                 265                 270         


Lys Ser Arg Val Arg Arg Asn Ser Pro Gln Val Gly Asp Ser Arg Glu 
        275                 280                 285             


Leu Lys Glu Thr Ile Asp Lys Ala Lys Lys Thr Leu Ser Thr Tyr Met 
    290                 295                 300                 


Val Thr Arg Leu Thr Lys Leu Asp Pro Ser Val Phe Trp Phe Ala Asp 
305                 310                 315                 320 


Leu Leu Met Asp Ala Lys Lys Val Val Glu Glu Tyr Lys Thr Lys Leu 
                325                 330                 335     


Glu Asp Ala Ser Asp Gln Lys Ser Val Glu Asp Leu Arg Lys Glu Ala 
            340                 345                 350         


Glu Gly Lys Ile Glu Ser Leu Ile Val Thr His Gln Asn Arg Glu Lys 
        355                 360                 365             


Glu Asn Gln Pro Ala Pro Gln Pro Gly Gly Gln Ala Gly Gly Ser Met 
    370                 375                 380                 


Val Val Pro Pro Val Thr Gln Thr Pro Pro Ser Thr Ser Gln Ser Pro 
385                 390                 395                 400 


Gly Gln Lys Ala Thr Glu Ala Glu Lys Lys Lys Leu Gln Asp Leu Ile 
                405                 410                 415     


Arg Gln Phe Gln Glu Ala Leu Asn Lys Leu Asp Asp Glu Thr Lys Thr 
            420                 425                 430         


Val Pro Asp Gly Gly Lys Leu Thr Gly Glu Ala Trp Lys Ala Tyr Asn 
        435                 440                 445             


Glu Thr Arg Thr Tyr Ala Lys Glu Val Val Asp Lys Ser Lys Lys Leu 
    450                 455                 460                 


Leu Ser Gln Thr Ala Val Thr Met Asp Glu Leu Ala Met Gln Leu Thr 
465                 470                 475                 480 


Lys Leu Asn Asp Ala Met Ser Lys Leu Lys Glu Ala Lys Ala Lys Leu 
                485                 490                 495     


Val Pro Glu Val Lys Pro Gln Pro Glu Asn Pro Glu Pro Lys Pro Gln 
            500                 505                 510         


Pro Glu Gly Glu Lys Pro Ser Val Pro Asp Ile Asn Gln Glu Lys Glu 
        515                 520                 525             


Lys Ala Lys Leu Ala Ile Ala Thr Tyr Met Ser Lys Ile Leu Asp Asp 
    530                 535                 540                 


Ile Lys Lys His His Leu Lys Lys Glu Lys His His Gln Ile Val Ala 
545                 550                 555                 560 


Leu Ile Lys Asp Leu Asp Lys Leu Lys Lys Gln Ala Leu Ser Glu Ile 
                565                 570                 575     


Asp Asn Val Asn Thr Lys Val Glu Ile Glu Asn Thr Val His Lys Val 
            580                 585                 590         


Phe Ala Ala Met Asp Thr Val Val Thr Asn Ser Lys Lys Ala Leu Ile 
        595                 600                 605             


Gln Asn Thr Pro Gln Val Pro Glu Ala Pro Lys Ser Pro Glu Val Pro 
    610                 615                 620                 


Lys Val Ser Asp Thr Pro Lys Ala Pro Asp Thr Pro Gln Val Pro Glu 
625                 630                 635                 640 


Ala Pro Lys Ala Pro Asp Thr Pro Gln Ile Pro Glu Ala Pro Ala Pro 
                645                 650                 655     


Glu Thr Pro Ala Pro Ala Pro Glu Ala Pro Lys Thr Gly Trp Lys Gln 
            660                 665                 670         


Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr Asp Gly Ser Met Ala Thr 
        675                 680                 685             


Gly Trp Leu Glu Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly 
    690                 695                 700                 


Ala Met Ala Thr Gly Trp Leu Glu Tyr Asn Gly Ser Trp Tyr Tyr Leu 
705                 710                 715                 720 


Asn Thr Asn Gly Ala Met Glu Thr Gly Trp Leu Glu Tyr Asn Gly Ser 
                725                 730                 735     


Trp Tyr Tyr Leu Asn Thr Asn Gly Ala Met Glu Thr Gly Trp Leu Glu 
            740                 745                 750         


Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Thr Asn Gly Ala Met Glu Thr 
        755                 760                 765             


Gly Trp Leu Glu Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Thr Asn Gly 
    770                 775                 780                 


Ala Met Glu Thr Gly Trp Leu Glu Tyr Asn Gly Ser Trp Tyr Tyr Leu 
785                 790                 795                 800 


Asn Ala Asn Gly Ser Met Ala Thr Gly Trp Leu Lys Asp Gly Asp Thr 
                805                 810                 815     


Trp Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Glu Ser Gln Trp Phe 
            820                 825                 830         


Lys Val Ser Asp Lys Trp Tyr Tyr Val Asn Gly Ser Gly Ala Leu Ala 
        835                 840                 845             


Val Asn Thr Thr Val Asp Gly Tyr Gly Val Asn Ala Asn Gly Lys Trp 
    850                 855                 860                 


Val Asn 
865     


<210>  9
<211>  869
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  9

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Val Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Ile Thr Gln Val Pro Thr 
        35                  40                  45              


Ser Tyr Asn Lys Ala Asn Glu Ser Gln Thr Glu His Arg Lys Ala Ala 
    50                  55                  60                  


Lys Gln Val Asp Glu Asp Ile Lys Lys Met Leu Ser Glu Ile Gln Glu 
65                  70                  75                  80  


Tyr Ile Lys Lys Met Leu Ser Glu Ile Gln Leu Asp Lys Arg Lys Asp 
                85                  90                  95      


Thr Gln Asn Arg Thr Leu Asn Arg Lys Leu Ser Ala Ile Gln Thr Lys 
            100                 105                 110         


Tyr Leu Tyr Glu Leu Arg Val Leu Lys Glu Lys Ser Lys Lys Glu Glu 
        115                 120                 125             


Leu Thr Ser Lys Thr Lys Lys Glu Leu Asp Ala Ala Phe Glu Lys Phe 
    130                 135                 140                 


Lys Lys Glu Pro Glu Leu Thr Lys Lys Leu Ala Glu Ala Lys Gln Lys 
145                 150                 155                 160 


Ala Lys Ala Gln Lys Glu Glu Asp Phe Arg Asn Tyr Pro Thr Asn Thr 
                165                 170                 175     


Tyr Lys Thr Leu Glu Leu Glu Ile Ala Glu Phe Asp Val Lys Val Lys 
            180                 185                 190         


Glu Ala Asp Leu Glu Leu Val Lys Glu Glu Ala Lys Pro Arg Asn Glu 
        195                 200                 205             


Glu Lys Ile Lys Gln Ala Lys Ala Lys Val Glu Ser Lys Lys Ala Glu 
    210                 215                 220                 


Ala Thr Arg Leu Glu Glu Ile Lys Thr Glu Arg Lys Arg Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Lys Arg Lys Ala Gly Glu Ser Glu Glu Lys Ala Ala Glu Ala 
                245                 250                 255     


Asn Gln Lys Val Asp Thr Lys Glu Gln Gly Lys Pro Lys Arg Arg Ala 
            260                 265                 270         


Lys Arg Gly Val Ser Gly Glu Leu Ala Thr Pro Asp Lys Lys Glu Asn 
        275                 280                 285             


Asp Ala Lys Ser Ser Asp Ser Ser Val Gly Glu Glu Thr Leu Pro Ser 
    290                 295                 300                 


Pro Ser Leu Asn Met Ala Asn Glu Ser Gln Thr Glu His Arg Lys Asp 
305                 310                 315                 320 


Val Asp Glu Tyr Ile Lys Lys Met Leu Ser Gly Ile Gln Leu Asp Arg 
                325                 330                 335     


Arg Lys Gln Thr Gln Asn Val Asn Leu Asn Ile Lys Leu Ser Ala Ile 
            340                 345                 350         


Lys Thr Lys Tyr Leu Tyr Glu Leu Ser Val Leu Lys Glu Asn Ser Lys 
        355                 360                 365             


Lys Glu Glu Leu Thr Ser Lys Thr Lys Ala Glu Leu Thr Ala Ala Phe 
    370                 375                 380                 


Glu Gln Phe Lys Lys Asp Thr Leu Lys Pro Glu Lys Lys Val Ala Glu 
385                 390                 395                 400 


Ala Glu Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Lys Asp Gln Lys 
                405                 410                 415     


Glu Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu 
            420                 425                 430         


Leu Glu Ile Ala Glu Ser Asp Val Lys Val Lys Glu Ala Glu Leu Glu 
        435                 440                 445             


Leu Val Lys Glu Glu Ala Asn Glu Ser Arg Asn Glu Glu Lys Ile Lys 
    450                 455                 460                 


Gln Ala Lys Glu Lys Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu 
465                 470                 475                 480 


Glu Lys Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg 
                485                 490                 495     


Lys Ala Glu Glu Ser Glu Lys Lys Ala Ala Glu Ala Lys Gln Lys Val 
            500                 505                 510         


Asp Ala Glu Glu Tyr Ala Leu Glu Ala Lys Ile Ala Glu Leu Glu Tyr 
        515                 520                 525             


Glu Val Gln Arg Leu Glu Lys Glu Leu Lys Glu Ile Asp Glu Ser Asp 
    530                 535                 540                 


Ser Glu Asp Tyr Leu Lys Glu Gly Leu Arg Ala Pro Leu Gln Ser Lys 
545                 550                 555                 560 


Leu Asp Thr Lys Lys Ala Lys Leu Ser Lys Leu Glu Glu Leu Ser Asp 
                565                 570                 575     


Lys Ile Asp Glu Leu Asp Val Asn Cys Asn Leu Arg Ser Gln Leu Lys 
            580                 585                 590         


Asp Ala Glu Gly Asn Asn Asn Val Glu Ala Tyr Phe Lys Glu Gly Leu 
        595                 600                 605             


Glu Lys Thr Thr Ala Glu Lys Lys Ala Glu Leu Glu Lys Ala Glu Ala 
    610                 615                 620                 


Asp Leu Lys Lys Ala Val Asp Glu Pro Glu Thr Pro Ala Pro Ala Pro 
625                 630                 635                 640 


Gln Pro Ala Pro Ala Pro Glu Lys Pro Ala Glu Lys Gln Ala Pro Ala 
                645                 650                 655     


Ser Ser Pro Glu Lys Pro Ala Pro Ala Pro Glu Lys Pro Gly Pro Ala 
            660                 665                 670         


Pro Glu Lys Pro Ala Pro Ala Pro Glu Lys Pro Ala Pro Thr Pro Glu 
        675                 680                 685             


Thr Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr 
    690                 695                 700                 


Asn Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser 
705                 710                 715                 720 


Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln 
                725                 730                 735     


Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr 
            740                 745                 750         


Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly 
        755                 760                 765             


Asp Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu 
    770                 775                 780                 


Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser 
785                 790                 795                 800 


Trp Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Val Lys 
                805                 810                 815     


Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala 
            820                 825                 830         


Arg Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val Asn Gly Ser Gly 
        835                 840                 845             


Ala Leu Ala Val Asn Thr Thr Val Asp Ser Tyr Arg Val Asn Ala Asn 
    850                 855                 860                 


Gly Glu Trp Val Asn 
865                 


<210>  10
<211>  681
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  10

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Phe Leu Gly 
            20                  25                  30          


Gly Val Ala His Ala Glu Gly Val Arg Ile Gly Asn Asn Ser Thr Val 
        35                  40                  45              


Thr Ser Ser Gly Asp Glu Val Glu Ser His Leu Gln Ser Ile Leu Lys 
    50                  55                  60                  


Asp Val Asn Lys Asn Leu Lys Lys Val Gln His Thr Gln Asn Val Gly 
65                  70                  75                  80  


Leu Leu Thr Lys Leu Ser Glu Ile Lys Arg Lys Tyr Leu Tyr Glu Leu 
                85                  90                  95      


Lys Val Asn Gly Leu Glu Glu Lys Ser Lys Ala Glu Leu Thr Ser Lys 
            100                 105                 110         


Thr Lys Lys Glu Leu Thr Ala Ala Phe Glu Gln Phe Lys Lys Asp Thr 
        115                 120                 125             


Leu Ser Thr Glu Leu Glu Lys Lys Val Ala Glu Ala Gln Lys Lys Val 
    130                 135                 140                 


Ala Glu Ala Glu Lys Lys Ala Lys Ala Gln Lys Glu Glu Asp His Arg 
145                 150                 155                 160 


Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu Glu Ile Ala Glu 
                165                 170                 175     


Ser Asp Val Glu Val Lys Lys Ala Glu Leu Glu Leu Leu Lys Glu Glu 
            180                 185                 190         


Ala Lys Glu Ser Arg Asp Glu Gly Thr Ile Lys Gln Ala Glu Ala Lys 
        195                 200                 205             


Val Glu Ser Lys Lys Ala Glu Ala Thr Lys Leu Glu Lys Ile Lys Thr 
    210                 215                 220                 


Asp Arg Glu Lys Ala Glu Glu Glu Ala Lys Arg Arg Ala Asp Ala Lys 
225                 230                 235                 240 


Leu Gln Glu Ala Asn Val Ala Thr Ser Gly Gln Asp Lys Ser Lys Arg 
                245                 250                 255     


Arg Ala Lys Arg Ala Val Pro Gly Glu Pro Ala Thr Pro Asp Lys Lys 
            260                 265                 270         


Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly Glu Glu Thr Leu 
        275                 280                 285             


Pro Ser Pro Ser Leu Lys Pro Glu Lys Lys Val Ala Glu Ala Glu Lys 
    290                 295                 300                 


Lys Val Glu Glu Ala Glu Lys Lys Ala Lys Asp Gln Lys Glu Glu Asp 
305                 310                 315                 320 


Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu Glu Ile 
                325                 330                 335     


Ala Glu Ser Asp Val Lys Val Lys Glu Ala Glu Leu Glu Leu Val Lys 
            340                 345                 350         


Glu Glu Val Asn Glu Pro Arg Asn Glu Glu Lys Val Lys Gln Ala Lys 
        355                 360                 365             


Ala Glu Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu Lys Ile 
    370                 375                 380                 


Lys Thr Asp Arg Lys Lys Ala Glu Glu Ala Lys Arg Lys Ala Ala Glu 
385                 390                 395                 400 


Glu Asp Lys Val Lys Glu Lys Pro Ala Pro Ala Pro Gln Pro Ala Pro 
                405                 410                 415     


Ala Pro Gln Pro Glu Lys Pro Ala Glu Glu Thr Pro Ala Pro Ala Pro 
            420                 425                 430         


Lys Pro Glu Lys Pro Thr Glu Gln Pro Lys Ala Glu Lys Pro Asp Asp 
        435                 440                 445             


Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn 
    450                 455                 460                 


Arg Leu Thr Gln Gln Gln Pro Pro Lys Pro Glu Gln Pro Ala Pro Ala 
465                 470                 475                 480 


Pro Lys Ile Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
                485                 490                 495     


Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
            500                 505                 510         


Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
        515                 520                 525             


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
    530                 535                 540                 


Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ser Asn Gly Ala 
545                 550                 555                 560 


Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn 
                565                 570                 575     


Ala Asn Gly Ser Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
            580                 585                 590         


Tyr Tyr Leu Asn Ser Asn Gly Ala Met Val Thr Gly Trp Leu Gln Asn 
        595                 600                 605             


Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Asp 
    610                 615                 620                 


Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala 
625                 630                 635                 640 


Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val 
                645                 650                 655     


Asn Gly Ser Gly Ala Leu Ala Val Asn Thr Thr Val Asp Ser Tyr Arg 
            660                 665                 670         


Val Asn Ala Asn Gly Glu Trp Val Asn 
        675                 680     


<210>  11
<211>  769
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  11

Met Phe Lys Ser Asn Tyr Glu Arg Lys Met Cys Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Thr Thr Gln Ala Pro Thr 
        35                  40                  45              


Ser Ser Asn Arg Gly Asn Glu Ser Gln Ala Glu Gln Arg Arg Glu Leu 
    50                  55                  60                  


Asp Leu Glu Arg Asp Lys Val Lys Lys Glu Val Arg Glu Tyr Lys Glu 
65                  70                  75                  80  


Lys Lys Val Lys Glu Leu Tyr Ser Lys Ser Thr Lys Ser Arg His Lys 
                85                  90                  95      


Lys Thr Val Asp Ile Val Asn Lys Leu Gln Asn Ile Asn Asn Glu Tyr 
            100                 105                 110         


Leu Asn Lys Ile Ile Gln Ser Thr Ser Thr Tyr Glu Glu Leu Gln Lys 
        115                 120                 125             


Leu Met Met Glu Ser Gln Ser Glu Val Asp Lys Ala Val Ser Glu Phe 
    130                 135                 140                 


Glu Lys Asp Leu Ser Ser Ser Ser Ser Ser Gly Ser Ser Thr Glu Pro 
145                 150                 155                 160 


Glu Ala Ser Asp Thr Ala Lys Pro Asn Lys Pro Thr Glu Leu Glu Lys 
                165                 170                 175     


Lys Val Ala Glu Ala Gln Gln Lys Val Glu Glu Ala Glu Lys Lys Ala 
            180                 185                 190         


Lys Asp Gln Lys Glu Glu Asp Tyr Arg Asn Tyr Pro Thr Ile Thr Tyr 
        195                 200                 205             


Lys Thr Leu Glu Leu Glu Ile Ala Glu Phe Asp Val Lys Val Lys Glu 
    210                 215                 220                 


Ala Glu Leu Glu Leu Val Lys Val Lys Ala Lys Glu Ser Arg Asp Glu 
225                 230                 235                 240 


Lys Lys Ile Lys Gln Ala Glu Ala Glu Val Glu Ser Lys Gln Ala Glu 
                245                 250                 255     


Ala Thr Arg Leu Lys Lys Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu 
            260                 265                 270         


Glu Ala Lys Leu Lys Glu Ala Val Glu Lys Asn Ala Ala Thr Ser Glu 
        275                 280                 285             


Gln Gly Lys Pro Lys Arg Arg Val Lys Arg Arg Ala Leu Gly Glu Gln 
    290                 295                 300                 


Ala Thr Pro Asp Lys Lys Asp Tyr Phe Glu Lys Asp Phe Arg Pro Ala 
305                 310                 315                 320 


Phe Asn Lys Asn Arg Gln Met Val Ala Ile Gln Glu Ser Leu Asn Lys 
                325                 330                 335     


Leu Asp Gly Glu Thr Lys Thr Val Pro Asp Gly Ala Lys Leu Thr Gly 
            340                 345                 350         


Glu Ala Gly Asn Ala Tyr Asn Glu Val Arg Asp Tyr Ala Ile Lys Val 
        355                 360                 365             


Val Ser Glu Asn Lys Lys Leu Leu Ser Gln Thr Ala Val Thr Met Asp 
    370                 375                 380                 


Glu Leu Ala Met Gln Leu Thr Lys Leu Asn Asp Ala Met Ser Lys Leu 
385                 390                 395                 400 


Arg Glu Ala Lys Ala Lys Leu Val Pro Glu Val Lys Pro Gln Pro Glu 
                405                 410                 415     


Asn Pro Glu His Gln Arg Pro Thr Thr Pro Ala Pro Asp Thr Lys Pro 
            420                 425                 430         


Ile Pro Gln Pro Glu Gly Lys Lys Pro Ser Val Pro Asp Ile Asn Gln 
        435                 440                 445             


Glu Lys Glu Lys Ala Lys Leu Ala Val Ala Thr Tyr Met Ser Lys Ile 
    450                 455                 460                 


Leu Asp Asp Ile Gln Lys His His Leu Gln Lys Glu Lys His Arg Gln 
465                 470                 475                 480 


Ile Val Ala Leu Ile Lys Glu Leu Asp Glu Phe Lys Lys Gln Ala Leu 
                485                 490                 495     


Ser Glu Ile Asp Asn Val Asn Thr Lys Val Glu Ile Glu Asn Thr Val 
            500                 505                 510         


His Lys Ile Phe Ala Asp Met Asp Ala Val Val Thr Lys Phe Lys Lys 
        515                 520                 525             


Gly Leu Thr Gln Asp Thr Pro Lys Glu Pro Asp Asn Lys Lys Pro Ser 
    530                 535                 540                 


Ala Pro Lys Pro Gly Met Gln Pro Ser Pro Gln Pro Glu Gly Lys Lys 
545                 550                 555                 560 


Pro Ser Val Pro Ala Gln Pro Gly Thr Glu Asp Lys Lys Pro Ser Ala 
                565                 570                 575     


Pro Lys Pro Gly Met Gln Pro Ser Pro Gln Pro Glu Gly Lys Lys Pro 
            580                 585                 590         


Ser Val Pro Ala Gln Pro Gly Thr Glu Asp Lys Lys Pro Ser Ala Pro 
        595                 600                 605             


Lys Pro Asp Met Gln Pro Ser Pro Gln Pro Glu Gly Lys Lys Pro Ser 
    610                 615                 620                 


Val Pro Ala Gln Pro Gly Thr Glu Asp Lys Lys Pro Ser Ala Pro Lys 
625                 630                 635                 640 


Pro Gly Met Gln Pro Ser Pro Gln Pro Glu Gly Lys Lys Pro Ser Val 
                645                 650                 655     


Pro Ala Gln Pro Gly Thr Glu Asp Lys Lys Pro Ser Ala Pro Lys Pro 
            660                 665                 670         


Asp Met Gln Pro Ser Pro Gln Pro Glu Gly Lys Lys Pro Ser Val Pro 
        675                 680                 685             


Ala Gln Pro Gly Thr Glu Asp Lys Lys Pro Ser Ala Pro Lys Pro Asp 
    690                 695                 700                 


Met Gln Pro Ser Pro Gln Pro Glu Gly Lys Lys Pro Ser Val Pro Glu 
705                 710                 715                 720 


Ile Asn Gln Glu Lys Glu Lys Ala Lys Leu Ala Val Ala Thr Glu Lys 
                725                 730                 735     


Lys Leu Pro Ser Thr Gly Val Ala Ser Asn Leu Val Leu Glu Ile Ile 
            740                 745                 750         


Gly Leu Leu Gly Leu Ile Gly Thr Ser Phe Ile Ala Met Lys Arg Arg 
        755                 760                 765             


Lys 
    


<210>  12
<211>  503
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  12

Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Val Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Asn Glu Gly Ser Thr Gln Ala Ala Thr 
        35                  40                  45              


Ser Ser Asn Met Ala Asn Lys Ser Gln Thr Glu Gln Gly Glu Ile Asn 
    50                  55                  60                  


Ile Glu Arg Asp Lys Ala Lys Thr Ala Val Ser Glu Tyr Lys Glu Lys 
65                  70                  75                  80  


Lys Val Ser Glu Ile Tyr Thr Lys Leu Glu Arg Asp Arg His Lys Asp 
                85                  90                  95      


Thr Val Asp Leu Val Asn Lys Leu Gln Glu Ile Lys Asn Glu Tyr Leu 
            100                 105                 110         


Asn Lys Ile Val Glu Ser Thr Ser Thr Ile Glu Ile Gln Gly Leu Ile 
        115                 120                 125             


Thr Thr Ser Arg Ser Lys Leu Asp Glu Ala Val Ser Lys Tyr Lys Lys 
    130                 135                 140                 


Ala Pro Ser Ser Ser Ser Ser Ser Gly Ser Ser Thr Lys Pro Glu Thr 
145                 150                 155                 160 


Pro Gln Pro Glu Thr Ser Lys Pro Glu Val Lys Pro Glu Pro Glu Thr 
                165                 170                 175     


Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val 
            180                 185                 190         


Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu 
        195                 200                 205             


Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu 
    210                 215                 220                 


Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro 
225                 230                 235                 240 


Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro 
                245                 250                 255     


Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
            260                 265                 270         


Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys 
        275                 280                 285             


Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
    290                 295                 300                 


Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro 
305                 310                 315                 320 


Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys 
                325                 330                 335     


Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr 
            340                 345                 350         


Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val 
        355                 360                 365             


Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu 
    370                 375                 380                 


Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu 
385                 390                 395                 400 


Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro 
                405                 410                 415     


Glu Thr Pro Lys Pro Glu Val Lys Pro Asp Asn Ser Lys Pro Gln Ala 
            420                 425                 430         


Asp Asp Lys Lys Pro Ser Thr Pro Asn Asn Leu Ser Lys Asp Lys Gln 
        435                 440                 445             


Ser Ser Asn Gln Ala Ser Thr Asn Glu Asn Lys Lys Gln Gly Pro Ala 
    450                 455                 460                 


Thr Asn Lys Pro Lys Lys Ser Leu Pro Ser Thr Gly Ser Ile Ser Asn 
465                 470                 475                 480 


Leu Ala Leu Glu Ile Ala Gly Leu Leu Thr Leu Ala Gly Ala Thr Ile 
                485                 490                 495     


Leu Ala Lys Lys Arg Met Lys 
            500             


<210>  13
<211>  612
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  13

Met Phe Ala Ser Lys Asn Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      


Phe Ser Ile Gly Val Ala Ser Val Ala Val Ala Ser Leu Phe Met Gly 
            20                  25                  30          


Ser Val Val His Ala Thr Glu Lys Glu Val Thr Thr Gln Val Ala Thr 
        35                  40                  45              


Ser Ser Asn Lys Ala Asn Lys Ser Gln Thr Glu His Met Lys Ala Ala 
    50                  55                  60                  


Lys Gln Val Asp Glu Tyr Ile Glu Lys Met Leu Ser Glu Ile Gln Leu 
65                  70                  75                  80  


Asp Arg Arg Lys His Thr Gln Asn Val Gly Leu Leu Thr Lys Leu Gly 
                85                  90                  95      


Ala Ile Lys Thr Glu Tyr Leu Arg Gly Leu Ser Val Ser Lys Glu Lys 
            100                 105                 110         


Ser Thr Ala Glu Leu Pro Ser Glu Ile Lys Glu Lys Leu Thr Ala Ala 
        115                 120                 125             


Phe Glu Gln Phe Lys Lys Asp Thr Leu Lys Ser Gly Lys Lys Val Ala 
    130                 135                 140                 


Glu Ala Gln Lys Lys Ala Lys Asp Gln Lys Glu Ala Lys Gln Glu Ile 
145                 150                 155                 160 


Glu Ala Leu Ile Val Lys His Lys Gly Arg Glu Ile Asp Leu Asp Arg 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Val Thr Glu His Leu Lys Lys Leu Leu Asn 
            180                 185                 190         


Asp Ile Glu Lys Asn Leu Lys Lys Glu Gln His Thr His Thr Val Glu 
        195                 200                 205             


Leu Ile Lys Asn Leu Lys Asp Ile Glu Lys Thr Tyr Leu His Lys Leu 
    210                 215                 220                 


Asp Glu Ser Thr Gln Lys Ala Gln Leu Gln Lys Leu Ile Ala Glu Ser 
225                 230                 235                 240 


Gln Ser Lys Leu Asp Glu Ala Phe Ser Lys Phe Lys Asn Gly Leu Ser 
                245                 250                 255     


Ser Ser Ser Asn Ser Gly Ser Ser Thr Lys Pro Glu Thr Pro Gln Pro 
            260                 265                 270         


Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro 
        275                 280                 285             


Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
    290                 295                 300                 


Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys 
305                 310                 315                 320 


Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro 
                325                 330                 335     


Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro 
            340                 345                 350         


Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys 
        355                 360                 365             


Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr 
    370                 375                 380                 


Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val 
385                 390                 395                 400 


Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu 
                405                 410                 415     


Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu 
            420                 425                 430         


Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro 
        435                 440                 445             


Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro 
    450                 455                 460                 


Glu Val Lys Pro Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu 
465                 470                 475                 480 


Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Leu Glu Thr Pro Lys 
                485                 490                 495     


Pro Glu Val Lys Pro Glu Pro Glu Thr Pro Lys Pro Glu Val Lys Pro 
            500                 505                 510         


Glu Leu Glu Thr Pro Lys Pro Glu Val Lys Pro Glu Pro Glu Ile Pro 
        515                 520                 525             


Lys Pro Glu Val Lys Pro Asp Asn Ser Lys Pro Gln Ala Asp Asp Lys 
    530                 535                 540                 


Lys Pro Ser Thr Pro Asn Asn Leu Ser Lys Asp Lys Gln Ser Ser Asn 
545                 550                 555                 560 


Gln Ala Ser Thr Asn Glu Asn Lys Lys Gln Gly Pro Ala Thr Asn Lys 
                565                 570                 575     


Pro Lys Lys Ser Leu Pro Ser Thr Gly Ser Ile Ser Asn Leu Ala Leu 
            580                 585                 590         


Glu Ile Ala Gly Leu Leu Thr Leu Ala Gly Ala Thr Ile Leu Ala Lys 
        595                 600                 605             


Lys Arg Met Lys 
    610         


<210>  14
<211>  635
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  14

Met Asn Lys Lys Lys Met Ile Leu Thr Ser Leu Ala Ser Val Ala Ile 
1               5                   10                  15      


Leu Gly Ala Gly Phe Val Ala Ser Gln Pro Thr Phe Val Arg Ala Glu 
            20                  25                  30          


Glu Ser Pro Val Ala Ser Gln Ser Lys Ala Glu Lys Asp Tyr Asp Ala 
        35                  40                  45              


Ala Val Lys Lys Ser Glu Ala Ala Lys Lys Ala Tyr Glu Glu Ala Lys 
    50                  55                  60                  


Lys Ala Leu Glu Glu Ala Lys Val Ala Gln Lys Lys Tyr Glu Asp Asp 
65                  70                  75                  80  


Gln Lys Lys Thr Glu Glu Lys Ala Glu Leu Glu Lys Glu Ala Ser Glu 
                85                  90                  95      


Ala Ile Ala Lys Ala Thr Glu Glu Val Gln Gln Ala Tyr Leu Ala Tyr 
            100                 105                 110         


Gln Arg Ala Ser Asn Lys Ala Glu Ala Ala Lys Met Ile Glu Glu Ala 
        115                 120                 125             


Gln Arg Arg Glu Asn Glu Ala Arg Ala Lys Phe Thr Thr Ile Arg Thr 
    130                 135                 140                 


Thr Met Val Val Pro Glu Pro Glu Gln Leu Ala Glu Thr Lys Lys Lys 
145                 150                 155                 160 


Ala Glu Glu Ala Lys Ala Lys Glu Pro Lys Leu Ala Lys Lys Ala Ala 
                165                 170                 175     


Glu Ala Lys Ala Lys Leu Glu Glu Ala Glu Lys Lys Ala Thr Glu Ala 
            180                 185                 190         


Lys Gln Lys Val Asp Ala Glu Glu Val Ala Pro Gln Ala Lys Ile Ala 
        195                 200                 205             


Glu Leu Glu Asn Gln Val His Arg Leu Glu Gln Glu Leu Lys Glu Ile 
    210                 215                 220                 


Asp Glu Ser Glu Ser Glu Asp Tyr Ala Lys Glu Gly Phe Arg Ala Pro 
225                 230                 235                 240 


Leu Gln Ser Lys Leu Asp Ala Lys Lys Ala Lys Leu Ser Lys Leu Glu 
                245                 250                 255     


Glu Leu Ser Asp Lys Ile Asp Glu Leu Asp Ala Glu Ile Ala Lys Leu 
            260                 265                 270         


Glu Asp Gln Leu Lys Ala Ala Glu Glu Asn Asn Asn Val Glu Asp Tyr 
        275                 280                 285             


Phe Lys Glu Gly Leu Glu Lys Thr Ile Ala Ala Lys Lys Ala Glu Leu 
    290                 295                 300                 


Glu Lys Thr Glu Ala Asp Leu Lys Lys Ala Val Asn Glu Pro Glu Lys 
305                 310                 315                 320 


Ser Ala Glu Glu Pro Ser Gln Pro Glu Lys Pro Ala Glu Glu Ala Pro 
                325                 330                 335     


Ala Pro Glu Gln Pro Thr Glu Pro Thr Gln Pro Glu Lys Pro Ala Glu 
            340                 345                 350         


Glu Thr Pro Ala Pro Lys Pro Glu Lys Pro Ala Glu Gln Pro Lys Ala 
        355                 360                 365             


Glu Lys Thr Asp Asp Gln Gln Ala Glu Glu Asp Tyr Ala Arg Arg Ser 
    370                 375                 380                 


Glu Glu Glu Tyr Asn Arg Leu Thr Gln Gln Gln Pro Pro Lys Ala Glu 
385                 390                 395                 400 


Lys Pro Ala Pro Ala Pro Gln Pro Glu Gln Pro Ala Pro Ala Pro Lys 
                405                 410                 415     


Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr Asp 
            420                 425                 430         


Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr 
        435                 440                 445             


Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly 
    450                 455                 460                 


Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Ala 
465                 470                 475                 480 


Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala 
                485                 490                 495     


Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser 
            500                 505                 510         


Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp Tyr 
        515                 520                 525             


Tyr Val Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Tyr Asn 
    530                 535                 540                 


Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp 
545                 550                 555                 560 


Ala Lys Val Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met 
                565                 570                 575     


Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala 
            580                 585                 590         


Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp 
        595                 600                 605             


Tyr Tyr Val Asn Gly Ser Gly Ser Leu Ala Val Asn Thr Thr Val Asp 
    610                 615                 620                 


Gly Tyr Thr Val Asn Glu Asn Gly Glu Trp Val 
625                 630                 635 


<210>  15
<211>  665
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  15

Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      


Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          


Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              


Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  


Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  


Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      


Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         


Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             


Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 


His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 


Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     


Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         


Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             


Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 


Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 


Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     


Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         


Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             


Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 


Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 


Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     


Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         


Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             


Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 


Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 


Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     


Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         


Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             


Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 


Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 


Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     


Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         


Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             


Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 


Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 


Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     


Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         


Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             


Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 


Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 


Val Ala Gly Ala Ala Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     


Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 


<210>  16
<211>  839
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  16

Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      


Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val 
            20                  25                  30          


Lys Lys Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              


Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  


Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  


Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      


Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         


Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             


Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 


Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu His 
145                 150                 155                 160 


Ser His Asn His Gly Gly Gly Ser Asn Asp Gln Ala Val Val Ala Ala 
                165                 170                 175     


Arg Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala 
            180                 185                 190         


Ser Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly 
        195                 200                 205             


Asp His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu 
    210                 215                 220                 


Ala Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Tyr Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu 
                245                 250                 255     


Asn His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu 
            260                 265                 270         


Asn Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu 
        275                 280                 285             


Arg His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr 
    290                 295                 300                 


Ser Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His 
305                 310                 315                 320 


Phe Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg 
                325                 330                 335     


Ile Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg 
            340                 345                 350         


Pro Glu Gln Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Pro 
        355                 360                 365             


Gln Pro Ala Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu 
    370                 375                 380                 


Lys Leu Val Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe 
385                 390                 395                 400 


Glu Glu Asn Gly Val Ser Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala 
                405                 410                 415     


Glu Thr Ala Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu 
            420                 425                 430         


Ser His Lys Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg 
        435                 440                 445             


Glu Phe Tyr Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp 
    450                 455                 460                 


Leu Leu Asp Asn Lys Gly Arg Gln Val Asp Phe Glu Ala Leu Asp Asn 
465                 470                 475                 480 


Leu Leu Glu Arg Leu Lys Asp Val Pro Ser Asp Lys Val Lys Leu Val 
                485                 490                 495     


Asp Asp Ile Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu 
            500                 505                 510         


Gly Lys Pro Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val 
        515                 520                 525             


Ala Lys Leu Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp 
    530                 535                 540                 


Pro Arg Asp Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His 
545                 550                 555                 560 


Met Thr His Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu 
                565                 570                 575     


Arg Ala Ala Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro 
            580                 585                 590         


Ser Thr Asp His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu 
        595                 600                 605             


Ala Ile Tyr Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg 
    610                 615                 620                 


Met Pro Tyr Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu 
625                 630                 635                 640 


Ile Ile Pro His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe 
                645                 650                 655     


Asp Glu Gly Leu Tyr Glu Ala Pro Lys Gly Tyr Thr Leu Glu Asp Leu 
            660                 665                 670         


Leu Ala Thr Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His 
        675                 680                 685             


Ser Asp Asn Gly Phe Gly Asn Ala Ser Asp His Val Arg Lys Asn Lys 
    690                 695                 700                 


Val Asp Gln Asp Ser Lys Pro Asp Glu Asp Lys Glu His Asp Glu Val 
705                 710                 715                 720 


Ser Glu Pro Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Ala Gly 
                725                 730                 735     


Leu Asn Pro Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu 
            740                 745                 750         


Glu Thr Glu Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro 
        755                 760                 765             


Gln Val Glu Asn Ser Val Ile Asn Ala Lys Ile Ala Asp Ala Glu Ala 
    770                 775                 780                 


Leu Leu Glu Lys Val Thr Asp Pro Ser Ile Arg Gln Asn Ala Met Glu 
785                 790                 795                 800 


Thr Leu Thr Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn 
                805                 810                 815     


Asn Thr Ile Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu 
            820                 825                 830         


Ser Gln Pro Ala Pro Ile Gln 
        835                 


<210>  17
<211>  893
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  17

Met Leu Asn Arg Glu Thr His Met Lys Lys Val Arg Lys Ile Phe Gln 
1               5                   10                  15      


Lys Ala Val Ala Gly Leu Cys Cys Ile Ser Gln Leu Thr Ala Phe Ser 
            20                  25                  30          


Ser Ile Val Ala Leu Ala Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly 
        35                  40                  45              


Lys Val Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp 
    50                  55                  60                  


Ala Val Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln 
65                  70                  75                  80  


Arg Thr Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro 
                85                  90                  95      


Gly Thr Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro 
            100                 105                 110         


Ser Thr Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr 
        115                 120                 125             


Val Gln Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln 
    130                 135                 140                 


Tyr Pro Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile 
145                 150                 155                 160 


Ile Lys Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn 
                165                 170                 175     


Pro Asn Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg 
            180                 185                 190         


Ile Tyr Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu 
        195                 200                 205             


Thr Val Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro 
    210                 215                 220                 


Leu Asp Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile 
225                 230                 235                 240 


Arg Asn Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg 
                245                 250                 255     


Ser Leu Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu 
            260                 265                 270         


Val Thr Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu 
        275                 280                 285             


Lys Gly Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe 
    290                 295                 300                 


Trp Asn Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser 
305                 310                 315                 320 


Tyr Leu Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn 
                325                 330                 335     


Lys Val Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr 
            340                 345                 350         


Gln Phe Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu 
        355                 360                 365             


Ile Leu Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His 
    370                 375                 380                 


Ile Thr Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His 
385                 390                 395                 400 


Ala Thr Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser 
                405                 410                 415     


Lys Ser Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln 
            420                 425                 430         


Ala Thr Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr 
        435                 440                 445             


Gln Met Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala 
    450                 455                 460                 


Phe Pro Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr 
465                 470                 475                 480 


Ala Val Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp 
                485                 490                 495     


Arg Glu Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile 
            500                 505                 510         


Thr Asn His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala 
        515                 520                 525             


Pro Asp Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp 
    530                 535                 540                 


Pro Gly Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser 
545                 550                 555                 560 


Ser Lys Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu 
                565                 570                 575     


Glu Gln Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser 
            580                 585                 590         


Ile Glu Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu 
        595                 600                 605             


Gln Leu Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr 
    610                 615                 620                 


Ala Asn Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro 
625                 630                 635                 640 


Gln Asn Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr 
                645                 650                 655     


Thr Glu Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu 
            660                 665                 670         


Lys Val Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser 
        675                 680                 685             


Asn Lys Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu 
    690                 695                 700                 


Val Glu Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp 
705                 710                 715                 720 


Val Arg Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly 
                725                 730                 735     


Asp Ile Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg 
            740                 745                 750         


Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile 
        755                 760                 765             


Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly 
    770                 775                 780                 


Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg 
785                 790                 795                 800 


Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys 
                805                 810                 815     


Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr 
            820                 825                 830         


Ser Ile Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp 
        835                 840                 845             


Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Tyr Pro 
    850                 855                 860                 


Arg Thr Gly Gly Ile Gly Met Leu Pro Phe Tyr Leu Ile Gly Cys Met 
865                 870                 875                 880 


Met Met Gly Gly Val Leu Leu Tyr Thr Arg Lys His Pro 
                885                 890             


<210>  18
<211>  2004
<212>  PRT
<213>  Streptococcus pneumoniae

<400>  18

Met Glu Lys Tyr Phe Gly Glu Lys Gln Glu Arg Phe Ser Phe Arg Lys 
1               5                   10                  15      


Leu Ser Val Gly Leu Val Ser Ala Thr Ile Ser Ser Leu Phe Phe Met 
            20                  25                  30          


Ser Val Leu Ala Ser Ser Ser Val Asp Ala Gln Glu Thr Ala Gly Val 
        35                  40                  45              


His Tyr Lys Tyr Val Ala Asp Ser Glu Leu Ser Ser Glu Glu Lys Lys 
    50                  55                  60                  


Gln Leu Val Tyr Asp Ile Pro Thr Tyr Val Glu Asn Asp Asp Glu Thr 
65                  70                  75                  80  


Tyr Tyr Leu Val Tyr Lys Leu Asn Ser Gln Asn Gln Leu Ala Glu Leu 
                85                  90                  95      


Pro Asn Thr Gly Ser Lys Asn Glu Arg Gln Ala Leu Val Ala Gly Ala 
            100                 105                 110         


Ser Leu Ala Ala Met Gly Ile Leu Ile Phe Ala Val Ser Lys Lys Lys 
        115                 120                 125             


Val Lys Asn Lys Thr Val Leu His Leu Val Leu Val Ala Gly Ile Gly 
    130                 135                 140                 


Asn Gly Val Leu Val Ser Val His Ala Leu Glu Asn His Leu Leu Leu 
145                 150                 155                 160 


Asn Tyr Asn Thr Asp Tyr Glu Leu Thr Ser Gly Glu Lys Leu Pro Leu 
                165                 170                 175     


Pro Lys Glu Ile Ser Gly Tyr Thr Tyr Ile Gly Tyr Ile Lys Glu Gly 
            180                 185                 190         


Lys Thr Thr Ser Glu Ser Glu Val Ser Asn Gln Lys Ser Ser Val Ala 
        195                 200                 205             


Thr Pro Thr Lys Gln Gln Lys Val Asp Tyr Asn Val Thr Pro Asn Phe 
    210                 215                 220                 


Val Asp His Pro Ser Thr Val Gln Ala Ile Gln Glu Gln Thr Pro Val 
225                 230                 235                 240 


Ser Ser Thr Lys Pro Thr Glu Val Gln Val Val Glu Lys Pro Phe Ser 
                245                 250                 255     


Thr Glu Leu Ile Asn Pro Arg Lys Glu Glu Lys Gln Ser Ser Asp Ser 
            260                 265                 270         


Gln Glu Gln Leu Ala Glu His Lys Asn Leu Glu Thr Lys Lys Glu Glu 
        275                 280                 285             


Lys Ile Ser Pro Lys Glu Lys Thr Gly Val Asn Thr Leu Asn Pro Gln 
    290                 295                 300                 


Asp Glu Val Leu Ser Gly Gln Leu Asn Lys Pro Glu Leu Leu Tyr Arg 
305                 310                 315                 320 


Glu Glu Thr Met Glu Thr Lys Ile Asp Phe Gln Glu Glu Ile Gln Glu 
                325                 330                 335     


Asn Pro Asp Leu Ala Glu Gly Thr Val Arg Val Lys Gln Glu Gly Lys 
            340                 345                 350         


Leu Gly Lys Lys Val Glu Ile Val Arg Ile Phe Ser Val Asn Lys Glu 
        355                 360                 365             


Glu Val Ser Arg Glu Ile Val Ser Thr Ser Thr Thr Ala Pro Ser Pro 
    370                 375                 380                 


Arg Ile Val Glu Lys Gly Thr Lys Lys Thr Gln Val Ile Lys Glu Gln 
385                 390                 395                 400 


Pro Glu Thr Gly Val Glu His Lys Asp Val Gln Ser Gly Ala Ile Val 
                405                 410                 415     


Glu Pro Ala Ile Gln Pro Glu Leu Pro Glu Ala Val Val Ser Asp Lys 
            420                 425                 430         


Gly Glu Pro Glu Val Gln Pro Thr Leu Pro Glu Ala Val Val Thr Asp 
        435                 440                 445             


Lys Gly Glu Thr Glu Val Gln Pro Glu Ser Pro Asp Thr Val Val Ser 
    450                 455                 460                 


Asp Lys Gly Glu Pro Glu Gln Val Ala Pro Leu Pro Glu Tyr Lys Gly 
465                 470                 475                 480 


Asn Ile Glu Gln Val Lys Pro Glu Thr Pro Val Glu Lys Thr Lys Glu 
                485                 490                 495     


Gln Gly Pro Glu Lys Thr Glu Glu Val Pro Val Lys Pro Thr Glu Glu 
            500                 505                 510         


Thr Pro Val Asn Pro Asn Glu Gly Thr Thr Glu Gly Thr Ser Ile Gln 
        515                 520                 525             


Glu Ala Glu Asn Pro Val Gln Pro Ala Glu Glu Ser Thr Thr Asn Ser 
    530                 535                 540                 


Glu Lys Val Ser Pro Asp Thr Ser Ser Lys Asn Thr Gly Glu Val Ser 
545                 550                 555                 560 


Ser Asn Pro Ser Asp Ser Thr Thr Ser Val Gly Glu Ser Asn Lys Pro 
                565                 570                 575     


Glu His Asn Asp Ser Lys Asn Glu Asn Ser Glu Lys Thr Val Glu Glu 
            580                 585                 590         


Val Pro Val Asn Pro Asn Glu Gly Thr Val Glu Gly Thr Ser Asn Gln 
        595                 600                 605             


Glu Thr Glu Lys Pro Val Gln Pro Ala Glu Glu Thr Gln Thr Asn Ser 
    610                 615                 620                 


Gly Lys Ile Ala Asn Glu Asn Thr Gly Glu Val Ser Asn Lys Pro Ser 
625                 630                 635                 640 


Asp Ser Lys Pro Pro Val Glu Glu Ser Asn Gln Pro Glu Lys Asn Gly 
                645                 650                 655     


Thr Ala Thr Lys Pro Glu Asn Ser Gly Asn Thr Thr Ser Glu Asn Gly 
            660                 665                 670         


Gln Thr Glu Pro Glu Pro Ser Asn Gly Asn Ser Thr Glu Asp Val Ser 
        675                 680                 685             


Thr Glu Ser Asn Thr Ser Asn Ser Asn Gly Asn Glu Glu Ile Lys Gln 
    690                 695                 700                 


Glu Asn Glu Leu Asp Pro Asp Lys Lys Val Glu Glu Pro Glu Lys Thr 
705                 710                 715                 720 


Leu Glu Leu Arg Asn Val Ser Asp Leu Glu Leu Tyr Ser Leu Ser Asn 
                725                 730                 735     


Gly Thr Tyr Lys Gln His Ile Ser Leu Glu Gln Val Pro Ser Asn Pro 
            740                 745                 750         


Asn Ser Tyr Phe Val Lys Val Lys Ser Ser Ser Phe Lys Asp Val Tyr 
        755                 760                 765             


Leu Pro Val Ala Ser Ile Ser Glu Glu Arg Lys Asn Asp Lys Ile Leu 
    770                 775                 780                 


Tyr Lys Ile Thr Ala Lys Val Glu Lys Leu Gln Gln Glu Ile Glu Ser 
785                 790                 795                 800 


Arg Tyr Lys Asp Asn Phe Thr Phe Tyr Leu Ala Lys Lys Gly Thr Glu 
                805                 810                 815     


Glu Thr Thr Asn Phe Thr Ser Phe Ser Asn Leu Val Lys Ala Ile Asn 
            820                 825                 830         


Gln Asn Pro Ser Gly Thr Tyr His Leu Ala Ala Ser Leu Asn Ala Asn 
        835                 840                 845             


Glu Val Glu Leu Gly Pro Asp Glu Arg Ser Tyr Ile Lys Asp Thr Phe 
    850                 855                 860                 


Thr Gly Arg Leu Ile Gly Glu Lys Asp Gly Lys Asn Tyr Ala Ile Tyr 
865                 870                 875                 880 


Asn Leu Lys Lys Pro Leu Phe Glu Asn Leu Ser Gly Ala Thr Val Glu 
                885                 890                 895     


Lys Leu Ser Leu Lys Asn Val Ala Ile Ser Gly Lys Asp Asp Ile Gly 
            900                 905                 910         


Ser Leu Ala Asn Glu Ala Gln Asn Asn Thr Lys Ile Lys Gln Val His 
        915                 920                 925             


Val Asp Gly Val Leu Ala Gly Glu Arg Gly Ile Gly Gly Leu Leu Ala 
    930                 935                 940                 


Lys Ala Glu Gln Ser Ser Ile Thr Glu Ser Ser Phe Lys Gly Arg Ile 
945                 950                 955                 960 


Ile Asn Thr Tyr Glu Thr Thr Ala Ala Tyr Asn Ile Gly Gly Met Val 
                965                 970                 975     


Gly His Leu Thr Gly Asp Lys Ala Leu Leu Thr Lys Ser Lys Ala Thr 
            980                 985                 990         


Val Ala Ile Ser Ser Asn Thr Asn  Thr Ser Asp Gln Thr  Val Gly Gly 
        995                 1000                 1005             


Leu Ala  Gly Leu Val Asp Arg  Asp Ala Gln Ile Gln  Asp Ser Tyr 
    1010                 1015                 1020             


Ala Glu  Gly Asp Ile Asn Asn  Val Lys His Phe Gly  Arg Val Ala 
    1025                 1030                 1035             


Gly Val  Ala Gly Asn Leu Trp  Asp Arg Thr Ser Gly  Asp Val Arg 
    1040                 1045                 1050             


His Ala  Gly Ser Leu Thr Asn  Val Leu Ser Asp Val  Asn Val Thr 
    1055                 1060                 1065             


Asn Gly  Asn Ala Ile Thr Gly  Tyr His Tyr Asn Glu  Met Lys Val 
    1070                 1075                 1080             


Lys Asp  Thr Phe Ser Ser Lys  Ala Asn Arg Val Tyr  Asn Val Thr 
    1085                 1090                 1095             


Leu Val  Lys Asp Glu Val Val  Ser Lys Glu Ser Phe  Glu Glu Arg 
    1100                 1105                 1110             


Gly Thr  Met Leu Asp Ala Ser  Gln Ile Ala Ser Lys  Lys Ala Glu 
    1115                 1120                 1125             


Ile Asn  Pro Leu Ile Leu Pro  Thr Val Glu Pro Leu  Ser Thr Ser 
    1130                 1135                 1140             


Gly Lys  Lys Asp Ser Asp Phe  Ser Lys Val Ala Tyr  Tyr Gln Ala 
    1145                 1150                 1155             


Lys Arg  Asn Leu Thr Tyr Lys  Asn Ile Glu Lys Leu  Leu Pro Phe 
    1160                 1165                 1170             


Tyr Asn  Lys Ala Thr Ile Val  Lys Tyr Gly Asn Leu  Val Asn Glu 
    1175                 1180                 1185             


Asn Ser  Leu Leu Tyr Gln Lys  Glu Leu Leu Ser Ala  Val Met Met 
    1190                 1195                 1200             


Lys Asp  Asn Gln Val Ile Thr  Asp Ile Val Ser Asn  Lys Gln Thr 
    1205                 1210                 1215             


Ala Asn  Lys Leu Leu Leu His  Tyr Lys Asp Asp Leu  Ser Glu Lys 
    1220                 1225                 1230             


Leu Asp  Leu Lys Tyr Gln Asn  Asp Phe Ala Lys Leu  Ala Glu Tyr 
    1235                 1240                 1245             


Ser Leu  Gly Asn Thr Gly Leu  Leu Tyr Thr Pro Asn  Gln Phe Leu 
    1250                 1255                 1260             


Tyr Asp  Gln Thr Ser Ile Ile  Lys Gln Val Leu Pro  Asp Leu Gln 
    1265                 1270                 1275             


Lys Val  Asp Tyr His Ser Glu  Ala Ile Arg Lys Thr  Leu Gly Ile 
    1280                 1285                 1290             


Ser Pro  Asn Val Lys Gln Thr  Glu Leu Tyr Leu Glu  Asp Gln Phe 
    1295                 1300                 1305             


Ala Lys  Thr Lys Gln Gln Leu  Glu Asp Ser Leu Lys  Lys Leu Leu 
    1310                 1315                 1320             


Ser Ala  Asp Ala Gly Leu Ala  Ser Ala Asn Pro Val  Thr Glu Gly 
    1325                 1330                 1335             


Tyr Leu  Val Asp Lys Ile Lys  Arg Asn Lys Glu Ala  Leu Leu Leu 
    1340                 1345                 1350             


Gly Leu  Thr Tyr Leu Glu Arg  Trp Tyr Asn Phe Ser  Tyr Gly Gln 
    1355                 1360                 1365             


Val Asn  Val Lys Asp Leu Val  Leu Tyr His Leu Asp  Phe Phe Gly 
    1370                 1375                 1380             


Lys Gly  Asn Ala Ser Pro Leu  Asp Thr Leu Ile Glu  Leu Gly Lys 
    1385                 1390                 1395             


Ser Gly  Phe Asn Asn Leu Leu  Ala Lys Asn Asn Val  Asp Thr Tyr 
    1400                 1405                 1410             


Gly Ile  Ser Leu Ala Ser Gln  His Gly Thr Thr Asp  Leu Phe Ser 
    1415                 1420                 1425             


Thr Leu  Glu His Tyr Arg Lys  Val Phe Leu Pro Asn  Thr Ser Asn 
    1430                 1435                 1440             


Asn Asp  Trp Phe Lys Ser Glu  Thr Lys Ala Tyr Ile  Val Glu Glu 
    1445                 1450                 1455             


Lys Ser  Thr Ile Glu Glu Val  Lys Thr Lys Gln Gly  Leu Ala Gly 
    1460                 1465                 1470             


Thr Lys  Tyr Ser Ile Gly Val  Tyr Asp Arg Ile Thr  Ser Ala Thr 
    1475                 1480                 1485             


Trp Lys  Tyr Arg Asn Met Val  Leu Pro Leu Leu Thr  Leu Pro Glu 
    1490                 1495                 1500             


Arg Ser  Val Phe Val Ile Ser  Thr Met Ser Ser Leu  Gly Phe Gly 
    1505                 1510                 1515             


Ala Tyr  Asp Arg Tyr Arg Ser  Ser Asp His Lys Ala  Gly Lys Ala 
    1520                 1525                 1530             


Leu Asn  Asp Phe Val Glu Glu  Asn Ala Arg Glu Thr  Ala Lys Arg 
    1535                 1540                 1545             


Gln Arg  Asp His Tyr Asp Tyr  Trp Tyr Arg Ile Leu  Asp Asp Asn 
    1550                 1555                 1560             


Ala Arg  Glu Lys Leu Tyr Arg  Asn Ile Leu Leu Tyr  Asp Ala Tyr 
    1565                 1570                 1575             


Lys Phe  Gly Asp Asp Asn Thr  Val Gly Lys Ala Thr  Glu Val Ala 
    1580                 1585                 1590             


Asp Phe  Asp Asn Pro Asn Pro  Ala Met Gln His Phe  Phe Gly Pro 
    1595                 1600                 1605             


Val Gly  Asn Lys Val Gly His  Asn Gln His Gly Ala  Tyr Ala Thr 
    1610                 1615                 1620             


Gly Asp  Ala Val Tyr Tyr Met  Gly Tyr Arg Met Leu  Asp Lys Asp 
    1625                 1630                 1635             


Gly Ala  Ile Thr Tyr Thr His  Glu Met Thr His Asp  Ser Asp Gln 
    1640                 1645                 1650             


Asp Ile  Tyr Leu Gly Gly Tyr  Gly Arg Arg Ser Gly  Leu Gly Pro 
    1655                 1660                 1665             


Glu Phe  Phe Ala Lys Gly Leu  Leu Gln Ala Pro Asp  His Pro Asp 
    1670                 1675                 1680             


Asp Ala  Thr Ile Thr Ile Asn  Ser Ile Leu Lys His  Ser Lys Ser 
    1685                 1690                 1695             


Asp Ser  Thr Glu Ser Arg Arg  Leu Gln Val Leu Asp  Pro Thr Thr 
    1700                 1705                 1710             


Arg Phe  Asn Asn Ala Asp Asp  Leu Lys Gln Tyr Val  His Asn Met 
    1715                 1720                 1725             


Phe Asp  Val Val Tyr Met Leu  Glu Tyr Leu Glu Gly  Asn Ser Ile 
    1730                 1735                 1740             


Leu Lys  Leu Asp Thr Asn Gln  Lys Gln Gln Leu Leu  Arg Lys Val 
    1745                 1750                 1755             


Thr Asn  Glu Tyr His Pro Asp  Pro Asp Gly Asn Lys  Val Tyr Ala 
    1760                 1765                 1770             


Thr Asn  Val Val Arg Asn Leu  Thr Val Glu Glu Val  Glu Arg Leu 
    1775                 1780                 1785             


Arg Ser  Phe Asn Asp Leu Ile  Asp Asn Asn Ile Leu  Ser Ser Arg 
    1790                 1795                 1800             


Glu Tyr  Ala Ser Gly Lys Tyr  Glu Arg Asn Gly Tyr  Phe Thr Ile 
    1805                 1810                 1815             


Lys Leu  Phe Ala Pro Ile Tyr  Ala Ala Leu Ser Asn  Asp Ile Gly 
    1820                 1825                 1830             


Thr Pro  Gly Asp Leu Met Gly  Arg Arg Ile Ala Tyr  Glu Leu Leu 
    1835                 1840                 1845             


Ala Ala  Lys Gly Phe Lys Asp  Gly Met Val Pro Tyr  Ile Ser Asn 
    1850                 1855                 1860             


Gln Tyr  Glu Glu Glu Ala Lys  Gln Lys Gly Lys Thr  Ile Asn Leu 
    1865                 1870                 1875             


Tyr Gly  Lys Thr Arg Gly Leu  Val Thr Asp Asp Leu  Val Leu Glu 
    1880                 1885                 1890             


Lys Val  Phe Asn Asn Gln Tyr  His Thr Trp Ser Glu  Phe Lys Lys 
    1895                 1900                 1905             


Ala Met  Tyr Gln Glu Arg Gln  Asp Gln Phe Asp Arg  Leu Asn Lys 
    1910                 1915                 1920             


Val Thr  Phe Asn Asp Thr Thr  Gln Pro Trp Gln Thr  Phe Ala Lys 
    1925                 1930                 1935             


Lys Thr  Thr Ser Ser Val Asp  Glu Leu Gln Lys Leu  Met Asp Val 
    1940                 1945                 1950             


Ala Val  Arg Lys Asp Ala Glu  His Asn Tyr Tyr His  Trp Asn Asn 
    1955                 1960                 1965             


Tyr Asn  Pro Asp Ile Asp Ser  Glu Val His Lys Leu  Lys Arg Ala 
    1970                 1975                 1980             


Ile Phe  Lys Ala Tyr Leu Asp  Gln Thr Asn Asp Phe  Arg Ser Ser 
    1985                 1990                 1995             


Ile Phe  Glu Asn Lys Lys 
    2000                 


