﻿                         序列表

<110>  四川大学

<120>  表达CXCR4的嵌合抗原受体修饰的淋巴细胞及制备方法和用途

<130>  G17P0021K

<141>  2017-12-28

<150>  201611253681.8
<151>  2016-12-30

<160>  32

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  268
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  1
Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          
Leu Ala Met Ser Leu Gly Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              
Glu Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln 
    50                  55                  60                  
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  
Glu Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Arg Val Gln Ala Glu Asp Ala Ala Ile Tyr 
            100                 105                 110         
Ser Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             
Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 
Gly Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Ser 
145                 150                 155                 160 
Glu Leu Lys Lys Pro Gly Glu Ser Val Lys Ile Ser Cys Lys Ala Ser 
                165                 170                 175     
Gly Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Gln Ala Pro 
            180                 185                 190         
Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu 
        195                 200                 205             
Pro Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Val Phe Ser Leu Asp 
    210                 215                 220                 
Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu 
225                 230                 235                 240 
Asp Thr Ala Val Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp 
                245                 250                 255     
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265             

<210>  2
<211>  804
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  2
atggtgctgc tggtgacctc cctgctgctg tgcgaactgc cccaccctgc cttcctgctg        60
attcccgaca tcgtgctgac ccagagccct gccagcctgg ccatgtccct gggcgaaagg       120
gccaccatct cctgcagggc cagcgagagc gtgagcgtta ttggagccca cttaattcac       180
tggtatcaac agaagcccgg ccagcccccc aagctgttaa tttatctggc ctccaacctg       240
gagacaggcg tgcctgccag atttagcggc agcggcagcg gcaccgattt taccctgacc       300
atctccaggg tgcaggccga agacgccgcc atctacagct gcctgcagag ccgtattttc       360
cctaggacct tcggccaggg caccaagctg gaaattaagg gctccacaag cggcagcgga       420
aagcccggtt ctggcgaggg aagcacaaag ggacaaattc agctcgtgca gtccggctcc       480
gagctgaaga agcccggcga gtccgtgaaa attagctgca aggcctccgg ctacaccttc       540
accgactaca gcattaattg ggtgaagcag gctcctggcc agggcctgaa gtggatgggc       600
tggattaaca ccgaaaccag ggagcccgcc tacgcctacg actttagggg caggttcgtg       660
ttcagcctgg acacctccgc cagcaccgcc tacctccaaa ttagctccct gaaggccgag       720
gacaccgccg tgtacttctg cgccctggac tacagctacg ccatggacta ctggggacag       780
ggcacactgg tcaccgtgag ctcc                                              804

<210>  3
<211>  22
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  3
Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      
Ala Phe Leu Leu Ile Pro 
            20          

<210>  4
<211>  66
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  4
atggtgctgc tggtgacctc cctgctgctg tgcgaactgc cccaccctgc cttcctgctg        60
attccc                                                                   66

<210>  5
<211>  86
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  5
Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr 
1               5                   10                  15      
Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
            20                  25                  30          
Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
        35                  40                  45              
His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
    50                  55                  60                  
Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
65                  70                  75                  80  
Tyr Cys Asn His Arg Asn 
                85      

<210>  6
<211>  258
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  6
gcggccgcat tcgtgccggt cttcctgcca gcgaagccca ccacgacgcc agcgccgcga        60
ccaccaacac cggcgcccac catcgcgtcg cagcccctgt ccctgcgccc agaggcgtgc       120
cggccagcgg cggggggcgc agtgcacacg agggggctgg acttcgcctg tgatatctac       180
atctgggcgc ccttggccgg gacttgtggg gtccttctcc tgtcactggt tatcaccctt       240
tactgcaacc acaggaac                                                     258

<210>  7
<211>  41
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  7
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      
Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          
Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      

<210>  8
<211>  123
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  8
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc        60
gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc       120
tcc                                                                     123

<210>  9
<211>  42
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  9
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210>  10
<211>  141
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  10
aggttcagcg tcgtgaagag aggaaggaag aagctcctgt atatcttcaa gcagcctttc        60
atgaggcccg tgcagaccac ccaggaagag gacggctgct cctgtaggtt tcccgaagag       120
gaggagggag gatgcgagct g                                                 141

<210>  11
<211>  113
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  11
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210>  12
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  12
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc        60
tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc       120
cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat       180
gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc       240
cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc       300
tacgacgccc ttcacatgca ggccctgccc cctcgc                                 336

<210>  13
<211>  554
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  13
Met Val Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      
Ala Phe Leu Leu Ile Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
            20                  25                  30          
Leu Ala Met Ser Leu Gly Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser 
        35                  40                  45              
Glu Ser Val Ser Val Ile Gly Ala His Leu Ile His Trp Tyr Gln Gln 
    50                  55                  60                  
Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu 
65                  70                  75                  80  
Glu Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      
Phe Thr Leu Thr Ile Ser Arg Val Gln Ala Glu Asp Ala Ala Ile Tyr 
            100                 105                 110         
Ser Cys Leu Gln Ser Arg Ile Phe Pro Arg Thr Phe Gly Gln Gly Thr 
        115                 120                 125             
Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 
Gly Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Ser 
145                 150                 155                 160 
Glu Leu Lys Lys Pro Gly Glu Ser Val Lys Ile Ser Cys Lys Ala Ser 
                165                 170                 175     
Gly Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Gln Ala Pro 
            180                 185                 190         
Gly Gln Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu 
        195                 200                 205             
Pro Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Val Phe Ser Leu Asp 
    210                 215                 220                 
Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Ser Ser Leu Lys Ala Glu 
225                 230                 235                 240 
Asp Thr Ala Val Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp 
                245                 250                 255     
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Phe 
            260                 265                 270         
Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             
Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 
Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 
Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                325                 330                 335     
Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            340                 345                 350         
Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
        355                 360                 365             
Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
    370                 375                 380                 
Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Phe Ser Val Val 
385                 390                 395                 400 
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                405                 410                 415     
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            420                 425                 430         
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        435                 440                 445             
Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    450                 455                 460                 
Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
465                 470                 475                 480 
Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                485                 490                 495     
Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            500                 505                 510         
Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        515                 520                 525             
Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    530                 535                 540                 
Ala Leu His Met Gln Ala Leu Pro Pro Arg 
545                 550                 

<210>  14
<211>  1665
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  14
atggtgctgc tggtgacctc cctgctgctg tgcgaactgc cccaccctgc cttcctgctg        60
attcccgaca tcgtgctgac ccagagccct gccagcctgg ccatgtccct gggcgaaagg       120
gccaccatct cctgcagggc cagcgagagc gtgagcgtta ttggagccca cttaattcac       180
tggtatcaac agaagcccgg ccagcccccc aagctgttaa tttatctggc ctccaacctg       240
gagacaggcg tgcctgccag atttagcggc agcggcagcg gcaccgattt taccctgacc       300
atctccaggg tgcaggccga agacgccgcc atctacagct gcctgcagag ccgtattttc       360
cctaggacct tcggccaggg caccaagctg gaaattaagg gctccacaag cggcagcgga       420
aagcccggtt ctggcgaggg aagcacaaag ggacaaattc agctcgtgca gtccggctcc       480
gagctgaaga agcccggcga gtccgtgaaa attagctgca aggcctccgg ctacaccttc       540
accgactaca gcattaattg ggtgaagcag gctcctggcc agggcctgaa gtggatgggc       600
tggattaaca ccgaaaccag ggagcccgcc tacgcctacg actttagggg caggttcgtg       660
ttcagcctgg acacctccgc cagcaccgcc tacctccaaa ttagctccct gaaggccgag       720
gacaccgccg tgtacttctg cgccctggac tacagctacg ccatggacta ctggggacag       780
ggcacactgg tcaccgtgag ctccgcggcc gcattcgtgc cggtcttcct gccagcgaag       840
cccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc       900
ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg       960
ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt      1020
ctcctgtcac tggttatcac cctttactgc aaccacagga acaggagtaa gaggagcagg      1080
ctcctgcaca gtgactacat gaacatgact ccccgccgcc ccgggcccac ccgcaagcat      1140
taccagccct atgccccacc acgcgacttc gcagcctatc gctcccgttt ctctgttgtt      1200
aaacggggca gaaagaagct cctgtatata ttcaaacaac catttatgag accagtacaa      1260
actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      1320
gaactgagag tgaagttcag caggagcgca gacgcccccg cgtaccagca gggccagaac      1380
cagctctata acgagctcaa tctaggacga agagaggagt acgatgtttt ggacaagaga      1440
cgtggccggg accctgagat ggggggaaag ccgagaagga agaaccctca ggaaggcctg      1500
tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc      1560
gagcgccgga ggggcaaggg gcacgatggc ctttaccagg gtctcagtac agccaccaag      1620
gacacctacg acgcccttca catgcaggcc ctgccccctc gctaa                      1665

<210>  15
<211>  142
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  15
Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser 
1               5                   10                  15      
Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly 
            20                  25                  30          
Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr 
        35                  40                  45              
Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly 
    50                  55                  60                  
Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg 
65                  70                  75                  80  
Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys 
                85                  90                  95      
Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser Val 
            100                 105                 110         
Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr 
        115                 120                 125             
Phe Leu Gly Phe Val Lys Leu Ser Gly Gly Gly Ser Asp Pro 
    130                 135                 140         

<210>  16
<211>  425
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  16
agcgtgctgc acctggtgcc catcaacgcc accagcaagg acgatagcga cgtgaccgag        60
gtgatgtggc agcccgccct gaggagagga agaggcctgc aggcccaggg ctacggagtg       120
agaatccagg acgccggcgt gtacctgctg tacagccagg tgctgttcca ggacgtgacc       180
ttcactatgg gtcaggtggt gagcagagag ggccagggca gacaggagac cctgttcagg       240
tgcatcagaa gcatgccctc ccaccccgac agggcctaca acagctgcta ctccgccggc       300
gtgtttcacc tgcaccaggg cgacatcctg agcgttatta tccccagagc cagggccaag       360
ctgaacctgt ctcctcatgg taccttcctg ggctttgtga agctgagcgg cggcggctcc       420
gaccc                                                                   425

<210>  17
<211>  448
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  17
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser 
            20                  25                  30          
Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg 
        35                  40                  45              
Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp 
    50                  55                  60                  
Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr 
65                  70                  75                  80  
Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu 
                85                  90                  95      
Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala 
            100                 105                 110         
Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp 
        115                 120                 125             
Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser 
    130                 135                 140                 
Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu Ser Gly Gly Gly Ser 
145                 150                 155                 160 
Asp Pro Ala Ala Ala Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
                165                 170                 175     
Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            180                 185                 190         
Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        195                 200                 205             
Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    210                 215                 220                 
Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
225                 230                 235                 240 
Thr Leu Tyr Cys Asn His Arg Asn Arg Ser Lys Arg Ser Arg Leu Leu 
                245                 250                 255     
His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
            260                 265                 270         
Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
        275                 280                 285             
Ser Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    290                 295                 300                 
Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
305                 310                 315                 320 
Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                325                 330                 335     
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            340                 345                 350         
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        355                 360                 365             
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    370                 375                 380                 
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
385                 390                 395                 400 
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                405                 410                 415     
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            420                 425                 430         
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445             

<210>  18
<211>  1347
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  18
atggagaccg acaccctgct gctctgggtg ctgctgctgt gggtgcctgg aagcaccgga        60
agcgtgctgc acctggtgcc catcaacgcc accagcaagg acgatagcga cgtgaccgag       120
gtgatgtggc agcccgccct gaggagagga agaggcctgc aggcccaggg ctacggagtg       180
agaatccagg acgccggcgt gtacctgctg tacagccagg tgctgttcca ggacgtgacc       240
ttcactatgg gtcaggtggt gagcagagag ggccagggca gacaggagac cctgttcagg       300
tgcatcagaa gcatgccctc ccaccccgac agggcctaca acagctgcta ctccgccggc       360
gtgtttcacc tgcaccaggg cgacatcctg agcgttatta tccccagagc cagggccaag       420
ctgaacctgt ctcctcatgg taccttcctg ggctttgtga agctgagcgg cggcggctcc       480
gaccccgcgg ccgcattcgt gccggtcttc ctgccagcga agcccaccac gacgccagcg       540
ccgcgaccac caacaccggc gcccaccatc gcgtcgcagc ccctgtccct gcgcccagag       600
gcgtgccggc cagcggcggg gggcgcagtg cacacgaggg ggctggactt cgcctgtgat       660
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       720
accctttact gcaaccacag gaacaggagt aagaggagca ggctcctgca cagtgactac       780
atgaacatga ctccccgccg ccccgggccc acccgcaagc attaccagcc ctatgcccca       840
ccacgcgact tcgcagccta tcgctcccgt ttctctgttg ttaaacgggg cagaaagaag       900
ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat       960
ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgag agtgaagttc      1020
agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc      1080
aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag      1140
atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa      1200
gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag      1260
gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt      1320
cacatgcagg ccctgccccc tcgctaa                                          1347

<210>  19
<211>  351
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  19
Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met Gly 
1               5                   10                  15      
Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu Asn 
            20                  25                  30          
Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile Phe 
        35                  40                  45              
Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly Tyr 
    50                  55                  60                  
Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu Ser 
65                  70                  75                  80  
Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val Asp 
                85                  90                  95      
Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val His 
            100                 105                 110         
Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala Phe 
        115                 120                 125             
Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser Gln 
    130                 135                 140                 
Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val Trp 
145                 150                 155                 160 
Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn Val 
                165                 170                 175     
Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn Asp 
            180                 185                 190         
Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu Ile 
        195                 200                 205             
Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser Lys 
    210                 215                 220                 
Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr Thr 
225                 230                 235                 240 
Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr Ile 
                245                 250                 255     
Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln Gly 
            260                 265                 270         
Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu Ala 
        275                 280                 285             
Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe Leu 
    290                 295                 300                 
Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val Ser 
305                 310                 315                 320 
Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly His 
                325                 330                 335     
Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350     

<210>  20
<211>  1062
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  20
ggacccgagg gcatttccat ctacacctcc gacaactata ccgaggagat gggcagcggc        60
gactacgatt ccatgaagga gccctgtttc agggaggaga acgccaactt caacaaaatt       120
tttctcccca ccatctacag catcatcttc ctgacaggca tcgtgggaaa cggcctggtg       180
atcctggtga tgggctacca gaagaagctg aggagcatga ccgacaagta caggctccac       240
ctgagcgtgg ccgacctgct gtttgtcatt acactgccct tctgggccgt ggacgccgtg       300
gccaactggt atttcggcaa ctttctctgc aaggccgtcc atgtgatcta caccgtgaac       360
ctctacagca gcgtgctgat tctggccttc atcagcctgg ataggtacct ggccatcgtc       420
cacgccacca actcccagag gcctagaaag ctgctggccg agaaggtggt gtatgtgggc       480
gtctggattc ctgccctgct cctgaccatc cctgacttca tcttcgccaa cgtgagcgaa       540
gccgatgaca ggtacatctg cgacaggttc taccctaacg atctgtgggt ggtggtgttc       600
cagttccagc acatcatggt gggcctcatc ctgcccggca ttgtcatcct gtcctgctac       660
tgcatcatca tctccaagct cagccacagc aagggccatc aaaagaggaa ggccctgaag       720
accacagtga tcctgatcct ggccttcttt gcctgctggc tgccttacta catcggcatc       780
agcatcgaca gcttcatcct cctggagatc atcaagcagg gctgcgagtt tgagaacaca       840
gtccacaagt ggatctccat taccgaagcc ctcgccttct tccactgctg cctcaaccct       900
atcctgtacg ctttcctcgg cgccaagttc aagacctccg ctcagcatgc tctcaccagc       960
gtgtccagag gcagcagcct gaagatcctg agcaagggca agagaggcgg ccacagcagc      1020
gtgagcacag agtccgagag ctccagcttc cactccagct ga                         1062

<210>  21
<211>  22
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  21
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      
Glu Glu Asn Pro Gly Pro 
            20          

<210>  22
<211>  65
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  22
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct        60
ggacc                                                                    65

<210>  23
<211>  26
<212>  PRT
<213>  人工序列(Artificial Sequence)

<400>  23
Arg Arg Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      
Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      

<210>  24
<211>  63
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  24
ggaagcggag agggcagagg aagtctgcta acatgcggtg acgtcgagga gaatcctgga        60
cct                                                                      63

<210>  25
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  25
aggtttaaac tacggatggt gctgctggtg acctccc                                 37

<210>  26
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  26
atgactagtc ccgggttagc gagggggcag ggcctgc                                 37

<210>  27
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  27
aggtttaaac tacggatggt gctgctggtg acctccc                                 37

<210>  28
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  28
atgactagtc ccgggtcagc tggagtggaa gctggag                                 37

<210>  29
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  29
aggtttaaac tacggatgga gaccgacacc ctgctgc                                 37

<210>  30
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  30
atgactagtc ccgggttagc gagggggcag ggcctgc                                 37

<210>  31
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  31
aggtttaaac tacggatgga gaccgacacc ctgctgc                                 37

<210>  32
<211>  37
<212>  DNA
<213>  人工序列(Artificial Sequence)

<400>  32
atgactagtc ccgggtcagc tggagtggaa gctggag                                 37

