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<110>Ƽ޹˾
<120> һֶеǶϿԭ

<160> 54   

<170>  PatentIn version 3.5

<210>  1
<211>  245
<212>  PRT
<213>˹
<220>
<223>
<400>  1

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  2
<211>  150
<212>  PRT
<220>
<223>
<400>  2

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  3
<211>  114
<212>  PRT
<220>
<223>
<400>  3

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  4
<211>  72
<212>  PRT
<220>
<223>
<400>  4

Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      


Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          


Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              


Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  


Arg Asp Pro Ala Leu Val His Gln 
65                  70          


<210>  5
<211>  69
<212>  PRT
<220>
<223>

<400>  5

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  6
<211>  112
<212>  PRT
<220>
<223>
<400>  6

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  7
<211>  41
<212>  PRT
<220>
<223>
<400>  7

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  8
<211>  42
<212>  PRT
<220>
<223>
<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  547
<212>  PRT
<220>
<223>
<400>  9

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro Pro 
                245                 250                 255     


Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
            260                 265                 270         


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
        275                 280                 285             


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
    290                 295                 300                 


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
305                 310                 315                 320 


His Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                325                 330                 335     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            340                 345                 350         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        355                 360                 365             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    370                 375                 380                 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
385                 390                 395                 400 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                405                 410                 415     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            420                 425                 430         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
        435                 440                 445             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    450                 455                 460                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
465                 470                 475                 480 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                485                 490                 495     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            500                 505                 510         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        515                 520                 525             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    530                 535                 540                 


Arg Lys Leu 
545         


<210>  10
<211>  269
<212>  PRT
<220>
<223>
<400>  10

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
145                 150                 155                 160 


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
                165                 170                 175     


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
            180                 185                 190         


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
        195                 200                 205             


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
    210                 215                 220                 


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
225                 230                 235                 240 


Lys Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln 
                245                 250                 255     


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            260                 265                 


<210>  11
<211>  21
<212>  PRT
<220>
<223>
<400>  11

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  12
<211>  22
<212>  PRT
<220>
<223>
<400>  12

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  13
<211>  1698
<212>  DNA
<220>
<223>
<400>  13
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccggatatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc       120
accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa       180
ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca       240
tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag       300
caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga       360
ggggggacca agctggagat cacaggctcc acctctggct ccggcaagcc cggatctggc       420
gagggctcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc       480
tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta       540
agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt       600
gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc       660
aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac       720
tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg ccaaggaacc       780
tcagtcaccg tgagctcagg cggcggcgga tctatcacgt gccctccccc catgtccgtg       840
gaacacgcag acatctgggt caagagctac agcttgtact ccagggagcg gtacatttgt       900
aactctggtt tcaagcgtaa agccggcacg tccagcctga cggagtgcgt gttgaacaag       960
gccacgaatg tcgcccactg gacaaccccc agtctcaaat gcattagaga ccctgccctg      1020
gttcaccaaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      1080
cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      1140
agggggctgg acttcgcctg tgacatctac atctgggcgc ccttggccgg gacttgtggg      1200
gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg      1260
tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt      1320
agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg      1380
agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga actcaatcta      1440
ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg      1500
ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag      1560
atggcggagg cctacagtga gattgggatg aaaggcgagc ggcggagggg caaggggcac      1620
gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg      1680
caggccctgc cccctcgc                                                    1698

<210>  14
<211>  879
<212>  DNA
<220>
<223>
<400>  14
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc       60

ggccccccag gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc      120

ccagccctgc tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac      180

acatcggaga gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag      240

ctggccgcct tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca      300

caactgccca acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc      360

ggcacctacc tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg      420

cgggcagagc tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc      480

tcacccaggc cagccggcca gttccaaacc ctggtgggcg gaggaggctc caactgggtg      540

aacgtcatct ccgacctcaa gaagatcgag gacctgatcc agagcatgca catcgacgcc      600

accctgtata ccgagagcga cgtgcacccc tcctgtaaag tgaccgccat gaagtgcttc      660

ctgctggagc tgcaggtgat cagcctggag agcggcgacg ccagcatcca tgacaccgtg      720

gagaacctga tcatcctggc caataacagc ctgagctcca acggcaacgt gaccgagagc      780

ggctgcaagg aatgcgagga gctggagaag aagaacatta aggagttcct gcagagcttc      840

gtccacatcg tgcagatgtt cattaacacc tcctaatga                             879


<210>  15
<211>  125
<212>  PRT
<220>
<223>
<400>  15

Asp Ile Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Val Asp 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Thr Arg Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ile Tyr Trp Arg Gly Ser Tyr Tyr Thr Glu Gly Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Arg Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  117
<212>  PRT
<220>
<223>
<400>  16

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Met Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Trp Ser Thr Asp Asp Tyr Gly Val Asp Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  243
<212>  PRT
<220>
<223>
<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg 
225                 230                 235                 240 


Leu Glu Ile 
                


<210>  18
<211>  249
<212>  PRT
<220>
<223>
<400>  18

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Thr Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  19
<211>  118
<212>  PRT
<220>
<223>
<400>  19

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  20
<211>  182
<212>  PRT
<220>
<223>
<400>  20

Met Lys Val Leu Gln Glu Pro Thr Cys Val Ser Asp Tyr Met Ser Ile 
1               5                   10                  15      


Ser Thr Cys Glu Trp Lys Met Asn Gly Pro Thr Asn Cys Ser Thr Glu 
            20                  25                  30          


Leu Arg Leu Leu Tyr Gln Leu Val Phe Leu Leu Ser Glu Ala His Thr 
        35                  40                  45              


Cys Ile Pro Glu Asn Asn Gly Gly Ala Gly Cys Val Cys His Leu Leu 
    50                  55                  60                  


Met Asp Asp Val Val Ser Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala 
65                  70                  75                  80  


Gly Gln Gln Leu Leu Trp Lys Gly Ser Phe Lys Pro Ser Glu His Val 
                85                  90                  95      


Lys Pro Arg Ala Pro Gly Asn Leu Thr Val His Thr Asn Val Ser Asp 
            100                 105                 110         


Thr Leu Leu Leu Thr Trp Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu 
        115                 120                 125             


Tyr Asn His Leu Thr Tyr Ala Val Asn Ile Trp Ser Glu Asn Asp Pro 
    130                 135                 140                 


Ala Asp Phe Arg Ile Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg 
145                 150                 155                 160 


Ile Ala Ala Ser Thr Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val 
                165                 170                 175     


Arg Ala Trp Ala Gln Cys 
            180         


<210>  21
<211>  129
<212>  PRT
<220>
<223>
<400>  21

His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                  15      


Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                  25                  30          


Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                  40                  45              


Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                  55                  60                  


Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                  70                  75                  80  


Arg Leu Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                  90                  95      


Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                 105                 110         


Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                 120                 125             


Ser 
    


<210>  22
<211>  27
<212>  PRT
<220>
<223>
<400>  22

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  23
<211>  425
<212>  PRT
<220>
<223>
<400>  23

Asp Ile Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Val Asp 
            20                  25                  30          


Ala Met Ala Trp Phe Arg Gln Thr Arg Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ser Ile Ser Lys Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ile Tyr Trp Arg Gly Ser Tyr Tyr Thr Glu Gly Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Arg Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
    130                 135                 140                 


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
145                 150                 155                 160 


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
                165                 170                 175     


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
            180                 185                 190         


Cys Ile Arg Asp Pro Ala Leu Val His Gln Thr Thr Thr Pro Ala Pro 
        195                 200                 205             


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
    210                 215                 220                 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
225                 230                 235                 240 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
                245                 250                 255     


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
            260                 265                 270         


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
        275                 280                 285             


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
    290                 295                 300                 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
305                 310                 315                 320 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
                325                 330                 335     


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
            340                 345                 350         


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
        355                 360                 365             


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
    370                 375                 380                 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
385                 390                 395                 400 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
                405                 410                 415     


Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425 


<210>  24
<211>  418
<212>  PRT
<220>
<223>
<400>  24

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro 
        115                 120                 125             


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
    130                 135                 140                 


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
145                 150                 155                 160 


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
                165                 170                 175     


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu 
            180                 185                 190         


Val His Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        195                 200                 205             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    210                 215                 220                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
225                 230                 235                 240 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                245                 250                 255     


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
            260                 265                 270         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        275                 280                 285             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    290                 295                 300                 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
305                 310                 315                 320 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
                325                 330                 335     


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
            340                 345                 350         


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
        355                 360                 365             


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
    370                 375                 380                 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
385                 390                 395                 400 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
                405                 410                 415     


Pro Arg 
        


<210>  25
<211>  376
<212>  PRT
<220>
<223>
<400>  25

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro 
        115                 120                 125             


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
    130                 135                 140                 


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
145                 150                 155                 160 


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
                165                 170                 175     


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu 
            180                 185                 190         


Val His Gln Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        195                 200                 205             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    210                 215                 220                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
225                 230                 235                 240 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                245                 250                 255     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            260                 265                 270         


Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        275                 280                 285             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    290                 295                 300                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
305                 310                 315                 320 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                325                 330                 335     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            340                 345                 350         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        355                 360                 365             


His Met Gln Ala Leu Pro Pro Arg 
    370                 375     


<210>  26
<211>  528
<212>  PRT
<220>
<223>
<400>  26

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Met Lys Val Leu Gln 
        115                 120                 125             


Glu Pro Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp 
    130                 135                 140                 


Lys Met Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr 
145                 150                 155                 160 


Gln Leu Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn 
                165                 170                 175     


Asn Gly Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val 
            180                 185                 190         


Ser Ala Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu 
        195                 200                 205             


Trp Lys Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro 
    210                 215                 220                 


Gly Asn Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr 
225                 230                 235                 240 


Trp Ser Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr 
                245                 250                 255     


Tyr Ala Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile 
            260                 265                 270         


Tyr Asn Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr 
        275                 280                 285             


Leu Lys Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln 
    290                 295                 300                 


Cys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
305                 310                 315                 320 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                325                 330                 335     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            340                 345                 350         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        355                 360                 365             


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
    370                 375                 380                 


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
385                 390                 395                 400 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                405                 410                 415     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
            420                 425                 430         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        435                 440                 445             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    450                 455                 460                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


<210>  27
<211>  417
<212>  PRT
<220>
<223>
<400>  27

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro 
        115                 120                 125             


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
    130                 135                 140                 


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
145                 150                 155                 160 


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
                165                 170                 175     


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu 
            180                 185                 190         


Val His Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
        195                 200                 205             


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
    210                 215                 220                 


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
225                 230                 235                 240 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                245                 250                 255     


Ser Leu Val Ile Thr Leu Tyr Cys Arg Ser Lys Arg Ser Arg Leu Leu 
            260                 265                 270         


His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg 
        275                 280                 285             


Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg 
    290                 295                 300                 


Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
305                 310                 315                 320 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                325                 330                 335     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            340                 345                 350         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        355                 360                 365             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    370                 375                 380                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
385                 390                 395                 400 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                405                 410                 415     


Arg 
    


<210>  28
<211>  450
<212>  PRT
<220>
<223>
<400>  28

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro 
145                 150                 155                 160 


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
                165                 170                 175     


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
            180                 185                 190         


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
        195                 200                 205             


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu 
    210                 215                 220                 


Val His Gln Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
225                 230                 235                 240 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                245                 250                 255     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            260                 265                 270         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        275                 280                 285             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
    290                 295                 300                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
305                 310                 315                 320 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                325                 330                 335     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
            340                 345                 350         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        355                 360                 365             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    370                 375                 380                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                405                 410                 415     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            420                 425                 430         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        435                 440                 445             


Pro Arg 
    450 


<210>  29
<211>  460
<212>  PRT
<220>
<223>
<400>  29

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
        115                 120                 125             


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
    130                 135                 140                 


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
145                 150                 155                 160 


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                165                 170                 175     


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
            180                 185                 190         


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
        195                 200                 205             


Lys Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln 
    210                 215                 220                 


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Thr Thr Thr 
225                 230                 235                 240 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
                245                 250                 255     


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
            260                 265                 270         


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
        275                 280                 285             


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
    290                 295                 300                 


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  30
<211>  236
<212>  PRT
<220>
<223>
<400>  30

Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Asn Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Met Trp Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Trp Ser Thr Asp Asp Tyr Gly Val Asp Ser Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile 
        115                 120                 125             


Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp 
    130                 135                 140                 


Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr 
145                 150                 155                 160 


Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser 
                165                 170                 175     


Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala 
            180                 185                 190         


Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys 
        195                 200                 205             


Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln Ser 
    210                 215                 220                 


Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
225                 230                 235     


<210>  31
<211>  363
<212>  PRT
<220>
<223>
<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ile Gln Tyr Gly Asn Tyr Tyr Tyr Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala 
            180                 185                 190         


Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Arg Ser Asn Trp Pro Ile Thr Phe Gly Gln Gly Thr Arg 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Gly Gly Gly Ser Asn Trp Val Asn Val Ile Ser 
                245                 250                 255     


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
            260                 265                 270         


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
        275                 280                 285             


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
    290                 295                 300                 


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
305                 310                 315                 320 


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
                325                 330                 335     


Cys Glu Glu Leu Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
            340                 345                 350         


Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        355                 360             


<210>  32
<211>  368
<212>  PRT
<220>
<223>
<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Thr Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Val Thr Gly Asp Leu Glu Asp Ala Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Thr Ser 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
    130                 135                 140                 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Trp Ser Tyr Leu Asn 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Asn Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Arg Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Gln Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Asn Trp 
                245                 250                 255     


Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser 
            260                 265                 270         


Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser 
        275                 280                 285             


Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile 
    290                 295                 300                 


Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu 
305                 310                 315                 320 


Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu 
                325                 330                 335     


Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile Lys Glu 
            340                 345                 350         


Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        355                 360                 365             


<210>  33
<211>  237
<212>  PRT
<220>
<223>
<400>  33

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Arg Ile Ser Ser Asp Asp Met 
            20                  25                  30          


Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Thr 
        35                  40                  45              


Ile Tyr Glu Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Ala Asn Phe Tyr Ser Glu Gln Pro Phe Gln Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asn Trp Val Asn Val 
        115                 120                 125             


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
    130                 135                 140                 


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
145                 150                 155                 160 


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
                165                 170                 175     


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
            180                 185                 190         


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
        195                 200                 205             


Lys Glu Cys Glu Glu Leu Glu Lys Lys Asn Ile Lys Glu Phe Leu Gln 
    210                 215                 220                 


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
225                 230                 235         


<210>  34
<211>  227
<212>  PRT
<220>
<223>
<400>  34

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Gly Gly Gly Ser Ile Thr Cys Pro Pro 
145                 150                 155                 160 


Pro Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu 
                165                 170                 175     


Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala 
            180                 185                 190         


Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val 
        195                 200                 205             


Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu 
    210                 215                 220                 


Val His Gln 
225         


<210>  35
<211>  1575
<212>  DNA
<220>
<223>
<400>  35
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aagggatccg agcccaaatc ttgtgagaag      900

acccacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtgttcctc      960

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1020

gtggtggacg tgagccacga ggaccctgag gtcaagttca actggtacgt ggacggcgtg     1080

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1140

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1200

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1260

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag     1320

gtcagcctga cttgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1380

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1440

tccttcttcc tctactccaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtg     1500

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1560

ctgtctccgg gtaaa                                                      1575


<210>  36
<211>  1671
<212>  DNA
<220>
<223>
<400>  36
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc       60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag      120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc      180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc      240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg      300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag      360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc      420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc      480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg      540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt      600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag      660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg      720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat      780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta      840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg      900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg      960

aggaaaagaa agcgaatgac tgaccccacc aggagattct tcaaagtgac gcctccccca     1020

ggaagcgggc cccagaacca gtacgggaac gtgctgtctc tccccacacc cacctcaggc     1080

ctcggacgcg cccagcgttg ggccgcaggc ctggggggca ctgccccgtc ttatggaaac     1140

ccgagcagcg acgtccaggc ggatggagcc ttggggtccc ggagcccgcc gggagtgggc     1200

ccagaagaag aggaagggga gggctatgag gaacctgaca gtgaggagga ctccgagttc     1260

tatgagaacg actccaacct tgggcaggac cagctctccc aggatggcag cggctacgag     1320

aaccctgagg atgagcccct gggtcctgag gatgaagact ccttctccaa cgctgagtct     1380

tatgagaacg aggatgaaga gctgacccag ccggtcgcca ggacaatgga cttcctgagc     1440

cctcatgggt cagcctggga ccccagccgg gaagcaacct ccctggggtc ccagtcctat     1500

gaggatatga gaggaatcct gtatgcagcc ccccagctcc gctccattcg gggccagcct     1560

ggacccaatc atgaggaaga tgcagactct tatgagaaca tggataatcc cgatgggcca     1620

gacccagcct ggggaggagg gggccgcatg ggcacctgga gcaccaggtg a              1671


<210>  37
<211>  1773
<212>  DNA
<220>
<223>
<400>  37
atggaagatg ccaaaaacat taagaagggc ccagcgccat tctacccact cgaagacggg       60

accgccggcg agcagctgca caaagccatg aagcgctacg ccctggtgcc cggcaccatc      120

gcctttaccg acgcacatat cgaggtggac attacctacg ccgagtactt cgagatgagc      180

gttcggctgg cagaagctat gaagcgctat gggctgaata caaaccatcg gatcgtggtg      240

tgcagcgaga atagcttgca gttcttcatg cccgtgttgg gtgccctgtt catcggtgtg      300

gctgtggccc cagctaacga catctacaac gagcgcgagc tgctgaacag catgggcatc      360

agccagccca ccgtcgtatt cgtgagcaag aaagggctgc aaaagatcct caacgtgcaa      420

aagaagctac cgatcataca aaagatcatc atcatggata gcaagaccga ctaccagggc      480

ttccaaagca tgtacacctt cgtgacttcc catttgccac ccggcttcaa cgagtacgac      540

ttcgtgcccg agagcttcga ccgggacaaa accatcgccc tgatcatgaa cagtagtggc      600

agtaccggat tgcccaaggg cgtagcccta ccgcaccgca ccgcttgtgt ccgattcagt      660

catgcccgcg accccatctt cggcaaccag atcatccccg acaccgctat cctcagcgtg      720

gtgccatttc accacggctt cggcatgttc accacgctgg gctacttgat ctgcggcttt      780

cgggtcgtgc tcatgtaccg cttcgaggag gagctattct tgcgcagctt gcaagactat      840

aagattcaat ctgccctgct ggtgcccaca ctatttagct tcttcgctaa gagcactctc      900

atcgacaagt acgacctaag caacttgcac gagatcgcca gcggcggggc gccgctcagc      960

aaggaggtag gtgaggccgt ggccaaacgc ttccacctac caggcatccg ccagggctac     1020

ggcctgacag aaacaaccag cgccattctg atcacccccg aaggggacga caagcctggc     1080

gcagtaggca aggtggtgcc cttcttcgag gctaaggtgg tggacttgga caccggtaag     1140

acactgggtg tgaaccagcg cggcgagctg tgcgtccgtg gccccatgat catgagcggc     1200

tacgttaaca accccgaggc tacaaacgct ctcatcgaca aggacggctg gctgcacagc     1260

ggcgacatcg cctactggga cgaggacgag cacttcttca tcgtggaccg gctgaagagc     1320

ctgatcaaat acaagggcta ccaggtagcc ccagccgaac tggagagcat cctgctgcaa     1380

caccccaaca tcttcgacgc cggggtcgcc ggcctgcccg acgacgatgc cggcgagctg     1440

cccgccgcag tcgtcgtgct ggaacacggt aaaaccatga ccgagaagga gatcgtggac     1500

tatgtggcca gccaggttac aaccgccaag aagctgcgcg gtggtgttgt gttcgtggac     1560

gaggtgccta aaggactgac cggcaagttg gacgcccgca agatccgcga gattctcatt     1620

aaggccaaga agggcggcaa gatcgccgtg aattctcacg gcttccctcc cgaggtggag     1680

gagcaggccg ccggcaccct gcccatgagc tgcgcccagg agagcggcat ggatagacac     1740

cctgctgctt gcgccagcgc caggatcaac gtc                                  1773


<210>  38
<211>  470
<212>  PRT
<220>
<223>
<400>  38

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
                245                 250                 255     


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
            260                 265                 270         


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
        275                 280                 285             


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
    290                 295                 300                 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
305                 310                 315                 320 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                325                 330                 335     


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            340                 345                 350         


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        355                 360                 365             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    370                 375                 380                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
385                 390                 395                 400 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                405                 410                 415     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            420                 425                 430         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        435                 440                 445             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    450                 455                 460                 


Leu Pro Pro Arg Lys Leu 
465                 470 


<210> 39
<211>  284
<212>  PRT
<213>  ˹
<220>
<223>
<400>  39

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Gly Gly Gly Gly Ser His Lys Cys Asp Ile 
145                 150                 155                 160 


Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys 
                165                 170                 175     


Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys 
            180                 185                 190         


Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg 
        195                 200                 205             


Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr 
    210                 215                 220                 


Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Leu Leu Lys Arg 
225                 230                 235                 240 


Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val 
                245                 250                 255     


Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys 
            260                 265                 270         


Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
        275                 280                 
<210>40
<211> 1338
<212> DNA
<213>  ˹
<220>
<223>
<400>  40
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg        60
ccggatatcc aactgcaagc tagcggggga ggcttggtgc agcctggggg gtctctgaga       120
ctctcctgtg cagcctctgg acgcaccttc aatgtcgatg ctatggcttg gttccgccag       180
actcgcggga aggagcgtga gtttgtagca gctattagcc ggagtggtgg tagcacgtac       240
tatgcagact ccgtgaaggg ccgattcagc atctccaaag acaacgccaa aaacacgatg       300
tatctgcaaa tgaacagcct caaacctgag gacacggcca tttattactg tgcagctgca       360
atctactggc gtggtagtta ctacactgaa ggcaactatg actactgggg ccagaggacc       420
caggtcaccg tgagctcagg cggcggcgga tctatcacgt gccctccccc catgtccgtg       480
gaacacgcag acatctgggt caagagctac agcttgtact ccagggagcg gtacatttgt       540
aactctggtt tcaagcgtaa agccggcacg tccagcctga cggagtgcgt gttgaacaag       600
gccacgaatg tcgcccactg gacaaccccc agtctcaaat gcattagaga ccctgccctg       660
gttcaccaaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg       720
cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg       780
agggggctgg acttcgcctg tgacatctac atctgggcgc ccttggccgg gacttgtggg       840
gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg       900
tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt       960
agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg      1020
agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga actcaatcta      1080
ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg      1140
ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag      1200
atggcggagg cctacagtga gattgggatg aaaggcgagc ggcggagggg caaggggcac      1260
gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg      1320
caggccctgc cccctcgc                                                    1338

<210>41
<211>1320
<212> DNA
<213>  ˹
<220>
<223>
<400>  41

atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattct        60
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       120
tcctgtgcag cctccggata taggattagc tctgacgata tgagctgggt ccgccaggct       180
ccagggaagg gtctagagtg ggtatcaacc atttatgaga cagacggtag cacatactac       240
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat       300
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagagctaat       360
ttttatagtg agcagccctt ccagttttgg ggtcagggaa ccctggtcac cgtctcgagc       420
ggcggcggcg gatctatcac gtgccctccc cccatgtccg tggaacacgc agacatctgg       480
gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt       540
aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac       600
tggacaaccc ccagtctcaa atgcattaga gaccctgccc tggttcacca aaccacgacg       660
ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc       720
ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc       780
tgtgacatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg       840
gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca       900
tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa       960
gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg      1020
tacaagcagg gccagaacca gctctataac gaactcaatc taggacgaag agaggagtac      1080
gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag      1140
aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt      1200
gagattggga tgaaaggcga gcggcggagg ggcaaggggc acgatggcct ttaccagggt      1260
ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc      1320

<210>42
<211>  1317
<212> DNA
<213>  ˹
<220>
<223>
<400>  42

atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattct        60
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       120
tcctgtgcag cctccggata taggattagc tctgacgata tgagctgggt ccgccaggct       180
ccagggaagg gtctagagtg ggtatcaacc atttatgaga cagacggtag cacatactac       240
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat       300
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagagctaat       360
ttttatagtg agcagccctt ccagttttgg ggtcagggaa ccctggtcac cgtctcgagc       420
ggcggcggcg gatctatcac gtgccctccc cccatgtccg tggaacacgc agacatctgg       480
gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt       540
aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac       600
tggacaaccc ccagtctcaa atgcattaga gaccctgccc tggttcacca aaccacgacg       660
ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc       720
ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc       780
tgtgacatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg       840
gttatcaccc tttactgcag gagtaagagg agcaggctcc tgcacagtga ctacatgaac       900
atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc ccccccacgc       960
gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      1020
aagcagggcc agaaccagct ctataacgaa ctcaatctag gacgaagaga ggagtacgat      1080
gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac      1140
cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag      1200
attgggatga aaggcgagcg gcggaggggc aaggggcacg atggccttta ccagggtctc      1260
agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc         1317

<210>43
<211>  1650
<212> DNA
<213>  ˹
<220>
<223>
<400>  43
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattct        60
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       120
tcctgtgcag cctccggata taggattagc tctgacgata tgagctgggt ccgccaggct       180
ccagggaagg gtctagagtg ggtatcaacc atttatgaga cagacggtag cacatactac       240
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat       300
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagagctaat       360
ttttatagtg agcagccctt ccagttttgg ggtcagggaa ccctggtcac cgtctcgagc       420
ggcggcggcg gatctatgaa ggtcttgcag gagcccacct gcgtctccga ctacatgagc       480
atctctactt gcgagtggaa gatgaatggt cccaccaatt gcagcaccga gctccgcctg       540
ttgtaccagc tggtttttct gctctccgaa gcccacacgt gtatccctga gaacaacgga       600
ggcgcggggt gcgtgtgcca cctgctcatg gatgacgtgg tcagtgcgga taactataca       660
ctggacctgt gggctgggca gcagctgctg tggaagggct ccttcaagcc cagcgagcat       720
gtgaaaccca gggccccagg aaacctgaca gttcacacca atgtctccga cactctgctg       780
ctgacctgga gcaacccgta tccccctgac aattacctgt ataatcatct cacctatgca       840
gtcaacattt ggagtgaaaa cgacccggca gatttcagaa tctataacgt gacctaccta       900
gaaccctccc tccgcatcgc agccagcacc ctgaagtctg ggatttccta cagggcacgg       960
gtgagggcct gggctcagtg caccacgacg ccagcgccgc gaccaccaac accggcgccc      1020
accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      1080
gcagtgcaca cgagggggct ggacttcgcc tgtgacatct acatctgggc gcccttggcc      1140
gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga      1200
aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag      1260
gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg      1320
aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac      1380
gaactcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      1440
cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg      1500
cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcggcggagg      1560
ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac      1620
gcccttcaca tgcaggccct gccccctcgc                                       1650
<210>44
<211> 1194
<212> DNA
<213>  ˹
<220>
<223>
<400>  44
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattct        60
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       120
tcctgtgcag cctccggata taggattagc tctgacgata tgagctgggt ccgccaggct       180
ccagggaagg gtctagagtg ggtatcaacc atttatgaga cagacggtag cacatactac       240
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat       300
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagagctaat       360
ttttatagtg agcagccctt ccagttttgg ggtcagggaa ccctggtcac cgtctcgagc       420
ggcggcggcg gatctatcac gtgccctccc cccatgtccg tggaacacgc agacatctgg       480
gtcaagagct acagcttgta ctccagggag cggtacattt gtaactctgg tttcaagcgt       540
aaagccggca cgtccagcct gacggagtgc gtgttgaaca aggccacgaa tgtcgcccac       600
tggacaaccc ccagtctcaa atgcattaga gaccctgccc tggttcacca attttgggtg       660
ctggtggtgg ttggtggagt cctggcttgc tatagcttgc tagtaacagt ggcctttatt       720
attttctggg tgaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg       780
agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa       840
gaaggaggat gtgaactgag agtgaagttc agcaggagcg cagacgcccc cgcgtacaag       900
cagggccaga accagctcta taacgaactc aatctaggac gaagagagga gtacgatgtt       960
ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct      1020
caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt      1080
gggatgaaag gcgagcggcg gaggggcaag gggcacgatg gcctttacca gggtctcagt      1140
acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc            1194


<210>45
<211>1410
<212> DNA
<213>  ˹
<220>
<223>
<400>  45
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattct        60
ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc       120
ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg       180
gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc       240
gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg       300
cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc       360
tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca       420
gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc       480
aggccagccg gccagttcca aaccctggtg ggcggcggcg gatctatcac gtgccctccc       540
cccatgtccg tggaacacgc agacatctgg gtcaagagct acagcttgta ctccagggag       600
cggtacattt gtaactctgg tttcaagcgt aaagccggca cgtccagcct gacggagtgc       660
gtgttgaaca aggccacgaa tgtcgcccac tggacaaccc ccagtctcaa atgcattaga       720
gaccctgccc tggttcacca aaccacgacg ccagcgccgc gaccaccaac accggcgccc       780
accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc       840
gcagtgcaca cgagggggct ggacttcgcc tgtgacatct acatctgggc gcccttggcc       900
gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga       960
aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag      1020
gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg      1080
aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac      1140
gaactcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac      1200
cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg      1260
cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcggcggagg      1320
ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac      1380
gcccttcaca tgcaggccct gccccctcgc                                       1410

<210>46
<211> 1446
<212> DNA
<213>  ˹
<220>
<223>
<400>  46
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattct        60
caggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc       120
tcctgtgcag cctccggata taggattagc tctgacgata tgagctgggt ccgccaggct       180
ccagggaagg gtctagagtg ggtatcaacc atttatgaga cagacggtag cacatactac       240
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat       300
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gagagctaat       360
ttttatagtg agcagccctt ccagttttgg ggtcagggaa ccctggtcac cgtctcgagc       420
ggcggcggcg gatctaactg ggtgaacgtc atctccgacc tcaagaagat cgaggacctg       480
atccagagca tgcacatcga cgccaccctg tataccgaga gcgacgtgca cccctcctgt       540
aaagtgaccg ccatgaagtg cttcctgctg gagctgcagg tgatcagcct ggagagcggc       600
gacgccagca tccatgacac cgtggagaac ctgatcatcc tggccaataa cagcctgagc       660
tccaacggca acgtgaccga gagcggctgc aaggaatgcg aggagctgga gaagaagaac       720
attaaggagt tcctgcagag cttcgtccac atcgtgcaga tgttcattaa cacctccacc       780
acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc       840
ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac       900
ttcgcctgtg acatctacat ctgggcgccc ttggccggga cttgtggggt ccttctcctg       960
tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa      1020
caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt      1080
ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc      1140
cccgcgtaca agcagggcca gaaccagctc tataacgaac tcaatctagg acgaagagag      1200
gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      1260
aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      1320
tacagtgaga ttgggatgaa aggcgagcgg cggaggggca aggggcacga tggcctttac      1380
cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc      1440
cctcgc                                                                 1446

<210>47
<211>780
<212> DNA
<213>  ˹
<220>
<223>
<400>  47
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggccccgatg tgcagctgca agctagcgga ggcggcctgg tgcaagctgg agactccctg       120
aggctgagct gcgccgctag cggaaggacc ttcagcacct acaacatggg ctggttcagg       180
caggcccccg gaaaggacag ggagttcgtg gccgccatta tgtggtccgg cggcagcacc       240
tactatgccg acagcgtgaa gggcaggttc acaatctcca aggacaacgc caagaacacc       300
gtgtacctgc agatgaactc cctgaagccc gaggatacag ccgtgtactt ctgctggagc       360
accgatgatt acggagtcga cagctggggc cagggaaccc aggtgaccgt gagctccggc       420
ggaggaggct ccaactgggt gaacgtcatc tccgacctca agaagatcga ggacctgatc       480
cagagcatgc acatcgacgc caccctgtat accgagagcg acgtgcaccc ctcctgtaaa       540
gtgaccgcca tgaagtgctt cctgctggag ctgcaggtga tcagcctgga gagcggcgac       600
gccagcatcc atgacaccgt ggagaacctg atcatcctgg ccaataacag cctgagctcc       660
aacggcaacg tgaccgagag cggctgcaag gaatgcgagg agctggagaa gaagaacatt       720
aaggagttcc tgcagagctt cgtccacatc gtgcagatgt tcattaacac ctcctaatga       780

<210>48
<211>1158
<212> DNA
<213>  ˹
<220>
<223>
<400>  48
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggccccgagg tgcagctggt ggagagcgga ggcggactgg tgcagcctgg cagatccctc       120
agactgtcct gtgccgcctc cggcttcacc ttcaacgact acgccatgca ctgggtgagg       180
caggcccccg gaaaaggact ggagtgggtg tccaccatca gctggaactc cggatccatc       240
ggctacgccg actccgtgaa gggcaggttc accatctcca gggataacgc caagaagtcc       300
ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccctgtacta ctgcgccaag       360
gacatccagt acggaaacta ctactacggc atggacgtgt ggggacaagg caccaccgtg       420
acagtgagca gcggcggagg aggatccgga ggaggcggat ccggaggagg aggatccgag       480
atcgtgctga cccagagccc tgctaccctg agcctgagcc ctggcgagag agccaccctg       540
tcctgcaggg ctagccagtc cgtgtccagc tacctggcct ggtaccagca gaagcccggc       600
caagccccta ggctgctgat ctacgacgcc agcaataggg ccacaggcat ccccgccaga       660
tttagcggca gcggctccgg aaccgacttc acactgacca tcagctccct ggagcccgaa       720
gacttcgccg tgtattactg ccagcagagg agcaactggc ccatcacctt cggacagggc       780
accagactgg agatcggcgg aggaggctcc aactgggtga acgtcatctc cgacctcaag       840
aagatcgagg acctgatcca gagcatgcac atcgacgcca ccctgtatac cgagagcgac       900
gtgcacccct cctgtaaagt gaccgccatg aagtgcttcc tgctggagct gcaggtgatc       960
agcctggaga gcggcgacgc cagcatccat gacaccgtgg agaacctgat catcctggcc      1020
aataacagcc tgagctccaa cggcaacgtg accgagagcg gctgcaagga atgcgaggag      1080
ctggagaaga agaacattaa ggagttcctg cagagcttcg tccacatcgt gcagatgttc      1140
attaacacct cctaatga                                                    1158

<210>49
<211> 1176
<212> DNA
<213>  ˹
<220>
<223>
<400>  49
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggcccccagg tgcagctgca acagagcggc cctggactgg tgaagcccag ccagacactg       120
agcctcacct gcgccattag cggcgacagc gtgagctcca attccgccgc ctggaattgg       180
atcagacaga gcacaagcag gggcctggag tggctgggca ggacctacta caggagcaag       240
tggtacaacg actacgccgt gtccgtgaag agcaggatca caatcaaccc cgacaccagc       300
aagaaccagt tcagcctgca gctcaacagc gtcacccccg aagacaccgc cgtgtactac       360
tgcgccagag aggtgaccgg cgacctggag gacgccttcg acatctgggg ccaaggcacc       420
atggtgaccg tgagctccgg ctccacaagc ggaagcggca aacctggctc cggcgagggt       480
tctaccaaag gcgacatcca gatgacccag agcccttcct ccctgagcgc cagcgtgggc       540
gatagagtga caattacctg cagggccagc cagaccatct ggagctacct gaactggtac       600
cagcagaggc ccggaaaggc ccccaacctg ctgatctacg ccgcttccag cctgcagagc       660
ggcgtgccta gcaggttctc cggcagaggc agcggcaccg atttcaccct gacaatcagc       720
agcctgcagg ccgaagattt tgccacctac tactgccagc agagctacag catcccccag       780
accttcggcc agggcaccaa actggagatc aagggcggag gaggctccaa ctgggtgaac       840
gtcatctccg acctcaagaa gatcgaggac ctgatccaga gcatgcacat cgacgccacc       900
ctgtataccg agagcgacgt gcacccctcc tgtaaagtga ccgccatgaa gtgcttcctg       960
ctggagctgc aggtgatcag cctggagagc ggcgacgcca gcatccatga caccgtggag      1020
aacctgatca tcctggccaa taacagcctg agctccaacg gcaacgtgac cgagagcggc      1080
tgcaaggaat gcgaggagct ggagaagaag aacattaagg agttcctgca gagcttcgtc      1140
cacatcgtgc agatgttcat taacacctcc taatga                                1176

<210>50
<211> 924
<212> DNA
<213>  ˹
<220>
<223>
<400> 50
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggccccccag gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc       120
ccagccctgc tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac       180
acatcggaga gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag       240
ctggccgcct tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca       300
caactgccca acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc       360
ggcacctacc tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg       420
cgggcagagc tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc       480
tcacccaggc cagccggcca gttccaaacc ctggtgggcg gaggaggctc ccacaagtgc       540
gatatcacct tacaggagat catcaaaact ttgaacagcc tcacagagca gaagactctg       600
tgcaccgagt tgaccgtaac agacatcttt gctgcctcca agaacacaac tgagaaggaa       660
accttctgca gggctgcgac tgtgctccgg cagttctaca gccaccatga gaaggacact       720
cgctgcctgg gtgcgactgc acagcagttc cacaggcaca agcagctgat ccgactcctg       780
aaacggctcg acaggaacct ctggggcctg gcgggcttga attcctgtcc tgtgaaggaa       840
gccaaccaga gtacgttgga aaacttcttg gaaaggctaa agacgatcat gagagagaaa       900
tattcaaagt gttcgagcta atga                                              924
<210>51
<211> 789
<212> DNA
<213>  ˹
<220>
<223>
<400>  51
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggcccccagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg       120
cgtctctcct gtgcagcctc cggatatagg attagctctg acgatatgag ctgggtccgc       180
caggctccag ggaagggtct agagtgggta tcaaccattt atgagacaga cggtagcaca       240
tactacgcag actccgtgaa gggccggttc accatctccc gtgacaattc caagaacacg       300
ctgtatctgc aaatgaacag cctgcgtgcc gaggacaccg cggtatatta ttgcgcgaga       360
gctaattttt atagtgagca gcccttccag ttttggggtc agggaaccct ggtcaccgtc       420
tcgagcggcg gaggaggctc caactgggtg aacgtcatct ccgacctcaa gaagatcgag       480
gacctgatcc agagcatgca catcgacgcc accctgtata ccgagagcga cgtgcacccc       540
tcctgtaaag tgaccgccat gaagtgcttc ctgctggagc tgcaggtgat cagcctggag       600
agcggcgacg ccagcatcca tgacaccgtg gagaacctga tcatcctggc caataacagc       660
ctgagctcca acggcaacgt gaccgagagc ggctgcaagg aatgcgagga gctggagaag       720
aagaacatta aggagttcct gcagagcttc gtccacatcg tgcagatgtt cattaacacc       780
tcctaatga                                                               789

<210>52
<211> 414
<212> DNA
<213>  ˹
<220>
<223>
<400>52
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggccccaact gggtgaacgt catctccgac ctcaagaaga tcgaggacct gatccagagc       120
atgcacatcg acgccaccct gtataccgag agcgacgtgc acccctcctg taaagtgacc       180
gccatgaagt gcttcctgct ggagctgcag gtgatcagcc tggagagcgg cgacgccagc       240
atccatgaca ccgtggagaa cctgatcatc ctggccaata acagcctgag ctccaacggc       300
aacgtgaccg agagcggctg caaggaatgc gaggagctgg agaagaagaa cattaaggag       360
ttcctgcaga gcttcgtcca catcgtgcag atgttcatta acacctccta atga             414

<210>53
<211>288
<212> DNA
<213>  ˹
<220>
<223>
<400> 53

ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggccccatca cgtgccctcc ccccatgtcc gtggaacacg cagacatctg ggtcaagagc       120
tacagcttgt actccaggga gcggtacatt tgtaactctg gtttcaagcg taaagccggc       180
acgtccagcc tgacggagtg cgtgttgaac aaggccacga atgtcgccca ctggacaacc       240
cccagtctca aatgcattag agaccctgcc ctggttcacc aataatga                    288

<210>54
<211> 753
<212> DNA
<213>  ˹
<220>
<223>
<400>  54
ggaagcggcg ccaccaactt ctccctgctg aagcaagctg gcgacgtgga agagaacccc        60
ggccccccag gatggttctt agactcccca gacaggccct ggaacccccc caccttctcc       120
ccagccctgc tcgtggtgac cgaaggggac aacgccacct tcacctgcag cttctccaac       180
acatcggaga gcttcgtgct aaactggtac cgcatgagcc ccagcaacca gacggacaag       240
ctggccgcct tccccgagga ccgcagccag cccggccagg actgccgctt ccgtgtcaca       300
caactgccca acgggcgtga cttccacatg agcgtggtca gggcccggcg caatgacagc       360
ggcacctacc tctgtggggc catctccctg gcccccaagg cgcagatcaa agagagcctg       420
cgggcagagc tcagggtgac agagagaagg gcagaagtgc ccacagccca ccccagcccc       480
tcacccaggc cagccggcca gttccaaacc ctggtgggcg gaggaggctc catcacgtgc       540
cctcccccca tgtccgtgga acacgcagac atctgggtca agagctacag cttgtactcc       600
agggagcggt acatttgtaa ctctggtttc aagcgtaaag ccggcacgtc cagcctgacg       660
gagtgcgtgt tgaacaaggc cacgaatgtc gcccactgga caacccccag tctcaaatgc       720
attagagacc ctgccctggt tcaccaataa tga                                    753

