﻿                         SEQUENCE LISTING

<110>  畿晋庆三联（北京）生物技术有限公司
 
<120>  抗结核分枝杆菌（Mycobacterium tuberculosis）及其感染的药物及其应用

<130>  P170899-JJQ

<160>  21    

<170>  PatentIn version 3.3

<210>  1
<211>  81
<212>  DNA
<213>  抗体模拟物AM1的核苷酸序列

<400>  1
tcttattggc tgcattggat taaacagaga cctggtcagg gactgtggat cggatctcag     60

tccacgcatg tgccgagaac c                                               81


<210>  2
<211>  27
<212>  PRT
<213>  抗体模拟物AM1的氨基酸序列

<400>  2

Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Trp 
1               5                   10                  15      


Ile Gly Ser Gln Ser Thr His Val Pro Arg Thr 
            20                  25          


<210>  3
<211>  81
<212>  DNA
<213>  抗体模拟物AM2核苷酸序列

<400>  3
tcttattggc tgcattggat taaacagaga cctggtcagg gactgtggat cggaaccaga     60

ccggtgcata cgtcccagtc t                                               81


<210>  4
<211>  27
<212>  PRT
<213>  抗体模拟物AM2的氨基酸序列

<400>  4

Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Trp 
1               5                   10                  15      


Ile Gly Thr Arg Pro Val His Thr Ser Gln Ser 
            20                  25          


<210>  5
<211>  1959
<212>  DNA
<213>  抗生素 PMC-AM1的基因序列

<400>  5
atgtctgacc ctgtacgtat tacaaatccc ggtgcagaat cgctggggta tgattcagat     60

ggccatgaaa ttatggccgt tgatatttat gtaaaccctc cacgtgtcga tgtctttcat    120

ggtaccccgc ctgcatggag ttccttcggg aacaaaacca tctggggcgg aaacgagtgg    180

gttgatgatt ccccaacccg aagtgatatc gaaaaaaggg acaaggaaat cacagcgtac    240

aaaaacacgc tcagcgcgca gcagaaagag aatgagaata agcgtactga agccggaaaa    300

cgcctctctg cggcgattgc tgcaagggaa aaagatgaaa acacactgaa aacactccgt    360

gccggaaacg cagatgccgc tgatattaca cgacaggagt tcagactcct gcaggcagag    420

ctgagagaat acggattccg tactgaaatc gccggatatg acgccctccg gctgcataca    480

gagagccgga tgctgtttgc tgatgctgat tctcttcgta tatctccccg ggaggccagg    540

tcgttaatcg aacaggctga aaaacggcag aaggatgcgc agaacgcaga caagaaggcc    600

gctgatatgc ttgctgaata cgagcgcaga aaaggtattc tggacacccg gttgtcagag    660

ctggaaaaaa atggcggggc agcccttgcc gttcttgatg cacaacaggc ccgtctgctc    720

gggcagcaga cacggaatga cagggccatt tcagaggccc ggaataaact cagttcagtg    780

acggaatcgc ttaacacggc ccgtaatgca ttaaccagag ctgaacaaca gctgacgcaa    840

cagaaaaaca cgcctgacgg caaaacgata gtttcccctg aaaaattccc ggggcgttca    900

tcaacaaatc attctattgt tgtgagcggt gatccgagat ttgccggtac gataaaaatc    960

acaaccagcg cagtcatcga taaccgtgca aacctgaatt atcttctgag ccattccggt   1020

ctggactata aacgcaatat tctgaatgac cggaatccgg tggtgacaga ggatgtggaa   1080

ggtgacaaga aaatttataa tgctgaagtt gctgaatggg ataagttacg gcaaagattg   1140

cttgatgcca gaaataaaat cacctctgct gaatctgcgg taaattcggc gagaaataac   1200

ctcagtgcca gaacaaatga gcaaaagcat gcaaatgacg ctcttaatgc cctgttgaag   1260

gaaaaagaga atatacgtaa ccagctttcc ggcatcaatc agaagatagc ggaagagaaa   1320

agaaaacagg atgaactgaa ggcaacgaaa gacgcaatta atttcacaac agagttcctg   1380

aaatcagttt cagaaaaata tggtgcaaaa gctgagcagt tagccagaga gatggccggg   1440

caggctaaag ggaagaaaat acgtaatgtt gaagaggcat taaaaacgta tgaaaagtac   1500

cgggctgaca ttaacaaaaa aattaatgca aaagatcgtg cagcgattgc cgcagccctt   1560

gagtctgtga agctgtctga tatatcgtct aatctgaaca gattcagtcg gggactggga   1620

tatgcaggaa aatttacaag tcttgctgac tggatcactg agtttggtaa ggctgtccgg   1680

acagagaact ggcgtcctct ttttgttaaa acagaaacca tcatagcagg caatgccgca   1740

acggctcttg tggcactggt cttcagtatt cttaccggaa gcgctttagg cattatcggg   1800

tatggtttac tgatggctgt caccggtgcg ctgattgatg aatcgcttgt ggaaaaagcg   1860

aataagttct ggggtatttc ttattggctg cattggatta aacagagacc tggtcaggga   1920

ctgtggatcg gatctcagtc cacgcatgtg ccgagaacc                          1959


<210>  6
<211>  652
<212>  PRT
<213>  抗生素 PMC-AM1的氨基酸序列

<400>  6

Ser Asp Pro Val Arg Ile Thr Asn Pro Gly Ala Glu Ser Leu Gly Tyr 
1               5                   10                  15      


Asp Ser Asp Gly His Glu Ile Met Ala Val Asp Ile Tyr Val Asn Pro 
            20                  25                  30          


Pro Arg Val Asp Val Phe His Gly Thr Pro Pro Ala Trp Ser Ser Phe 
        35                  40                  45              


Gly Asn Lys Thr Ile Trp Gly Gly Asn Glu Trp Val Asp Asp Ser Pro 
    50                  55                  60                  


Thr Arg Ser Asp Ile Glu Lys Arg Asp Lys Glu Ile Thr Ala Tyr Lys 
65                  70                  75                  80  


Asn Thr Leu Ser Ala Gln Gln Lys Glu Asn Glu Asn Lys Arg Thr Glu 
                85                  90                  95      


Ala Gly Lys Arg Leu Ser Ala Ala Ile Ala Ala Arg Glu Lys Asp Glu 
            100                 105                 110         


Asn Thr Leu Lys Thr Leu Arg Ala Gly Asn Ala Asp Ala Ala Asp Ile 
        115                 120                 125             


Thr Arg Gln Glu Phe Arg Leu Leu Gln Ala Glu Leu Arg Glu Tyr Gly 
    130                 135                 140                 


Phe Arg Thr Glu Ile Ala Gly Tyr Asp Ala Leu Arg Leu His Thr Glu 
145                 150                 155                 160 


Ser Arg Met Leu Phe Ala Asp Ala Asp Ser Leu Arg Ile Ser Pro Arg 
                165                 170                 175     


Glu Ala Arg Ser Leu Ile Glu Gln Ala Glu Lys Arg Gln Lys Asp Ala 
            180                 185                 190         


Gln Asn Ala Asp Lys Lys Ala Ala Asp Met Leu Ala Glu Tyr Glu Arg 
        195                 200                 205             


Arg Lys Gly Ile Leu Asp Thr Arg Leu Ser Glu Leu Glu Lys Asn Gly 
    210                 215                 220                 


Gly Ala Ala Leu Ala Val Leu Asp Ala Gln Gln Ala Arg Leu Leu Gly 
225                 230                 235                 240 


Gln Gln Thr Arg Asn Asp Arg Ala Ile Ser Glu Ala Arg Asn Lys Leu 
                245                 250                 255     


Ser Ser Val Thr Glu Ser Leu Asn Thr Ala Arg Asn Ala Leu Thr Arg 
            260                 265                 270         


Ala Glu Gln Gln Leu Thr Gln Gln Lys Asn Thr Pro Asp Gly Lys Thr 
        275                 280                 285             


Ile Val Ser Pro Glu Lys Phe Pro Gly Arg Ser Ser Thr Asn His Ser 
    290                 295                 300                 


Ile Val Val Ser Gly Asp Pro Arg Phe Ala Gly Thr Ile Lys Ile Thr 
305                 310                 315                 320 


Thr Ser Ala Val Ile Asp Asn Arg Ala Asn Leu Asn Tyr Leu Leu Ser 
                325                 330                 335     


His Ser Gly Leu Asp Tyr Lys Arg Asn Ile Leu Asn Asp Arg Asn Pro 
            340                 345                 350         


Val Val Thr Glu Asp Val Glu Gly Asp Lys Lys Ile Tyr Asn Ala Glu 
        355                 360                 365             


Val Ala Glu Trp Asp Lys Leu Arg Gln Arg Leu Leu Asp Ala Arg Asn 
    370                 375                 380                 


Lys Ile Thr Ser Ala Glu Ser Ala Val Asn Ser Ala Arg Asn Asn Leu 
385                 390                 395                 400 


Ser Ala Arg Thr Asn Glu Gln Lys His Ala Asn Asp Ala Leu Asn Ala 
                405                 410                 415     


Leu Leu Lys Glu Lys Glu Asn Ile Arg Asn Gln Leu Ser Gly Ile Asn 
            420                 425                 430         


Gln Lys Ile Ala Glu Glu Lys Arg Lys Gln Asp Glu Leu Lys Ala Thr 
        435                 440                 445             


Lys Asp Ala Ile Asn Phe Thr Thr Glu Phe Leu Lys Ser Val Ser Glu 
    450                 455                 460                 


Lys Tyr Gly Ala Lys Ala Glu Gln Leu Ala Arg Glu Met Ala Gly Gln 
465                 470                 475                 480 


Ala Lys Gly Lys Lys Ile Arg Asn Val Glu Glu Ala Leu Lys Thr Tyr 
                485                 490                 495     


Glu Lys Tyr Arg Ala Asp Ile Asn Lys Lys Ile Asn Ala Lys Asp Arg 
            500                 505                 510         


Ala Ala Ile Ala Ala Ala Leu Glu Ser Val Lys Leu Ser Asp Ile Ser 
        515                 520                 525             


Ser Asn Leu Asn Arg Phe Ser Arg Gly Leu Gly Tyr Ala Gly Lys Phe 
    530                 535                 540                 


Thr Ser Leu Ala Asp Trp Ile Thr Glu Phe Gly Lys Ala Val Arg Thr 
545                 550                 555                 560 


Glu Asn Trp Arg Pro Leu Phe Val Lys Thr Glu Thr Ile Ile Ala Gly 
                565                 570                 575     


Asn Ala Ala Thr Ala Leu Val Ala Leu Val Phe Ser Ile Leu Thr Gly 
            580                 585                 590         


Ser Ala Leu Gly Ile Ile Gly Tyr Gly Leu Leu Met Ala Val Thr Gly 
        595                 600                 605             


Ala Leu Ile Asp Glu Ser Leu Val Glu Lys Ala Asn Lys Phe Trp Gly 
    610                 615                 620                 


Ile Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
625                 630                 635                 640 


Trp Ile Gly Ser Gln Ser Thr His Val Pro Arg Thr 
                645                 650         


<210>  7
<211>  1959
<212>  DNA
<213>  编码新型抗生素 PMC-SA2的核苷酸序列

<400>  7
atgtctgacc ctgtacgtat tacaaatccc ggtgcagaat cgctggggta tgattcagat     60

ggccatgaaa ttatggccgt tgatatttat gtaaaccctc cacgtgtcga tgtctttcat    120

ggtaccccgc ctgcatggag ttccttcggg aacaaaacca tctggggcgg aaacgagtgg    180

gttgatgatt ccccaacccg aagtgatatc gaaaaaaggg acaaggaaat cacagcgtac    240

aaaaacacgc tcagcgcgca gcagaaagag aatgagaata agcgtactga agccggaaaa    300

cgcctctctg cggcgattgc tgcaagggaa aaagatgaaa acacactgaa aacactccgt    360

gccggaaacg cagatgccgc tgatattaca cgacaggagt tcagactcct gcaggcagag    420

ctgagagaat acggattccg tactgaaatc gccggatatg acgccctccg gctgcataca    480

gagagccgga tgctgtttgc tgatgctgat tctcttcgta tatctccccg ggaggccagg    540

tcgttaatcg aacaggctga aaaacggcag aaggatgcgc agaacgcaga caagaaggcc    600

gctgatatgc ttgctgaata cgagcgcaga aaaggtattc tggacacccg gttgtcagag    660

ctggaaaaaa atggcggggc agcccttgcc gttcttgatg cacaacaggc ccgtctgctc    720

gggcagcaga cacggaatga cagggccatt tcagaggccc ggaataaact cagttcagtg    780

acggaatcgc ttaacacggc ccgtaatgca ttaaccagag ctgaacaaca gctgacgcaa    840

cagaaaaaca cgcctgacgg caaaacgata gtttcccctg aaaaattccc ggggcgttca    900

tcaacaaatc attctattgt tgtgagcggt gatccgagat ttgccggtac gataaaaatc    960

acaaccagcg cagtcatcga taaccgtgca aacctgaatt atcttctgag ccattccggt   1020

ctggactata aacgcaatat tctgaatgac cggaatccgg tggtgacaga ggatgtggaa   1080

ggtgacaaga aaatttataa tgctgaagtt gctgaatggg ataagttacg gcaaagattg   1140

cttgatgcca gaaataaaat cacctctgct gaatctgcgg taaattcggc gagaaataac   1200

ctcagtgcca gaacaaatga gcaaaagcat gcaaatgacg ctcttaatgc cctgttgaag   1260

gaaaaagaga atatacgtaa ccagctttcc ggcatcaatc agaagatagc ggaagagaaa   1320

agaaaacagg atgaactgaa ggcaacgaaa gacgcaatta atttcacaac agagttcctg   1380

aaatcagttt cagaaaaata tggtgcaaaa gctgagcagt tagccagaga gatggccggg   1440

caggctaaag ggaagaaaat acgtaatgtt gaagaggcat taaaaacgta tgaaaagtac   1500

cgggctgaca ttaacaaaaa aattaatgca aaagatcgtg cagcgattgc cgcagccctt   1560

gagtctgtga agctgtctga tatatcgtct aatctgaaca gattcagtcg gggactggga   1620

tatgcaggaa aatttacaag tcttgctgac tggatcactg agtttggtaa ggctgtccgg   1680

acagagaact ggcgtcctct ttttgttaaa acagaaacca tcatagcagg caatgccgca   1740

acggctcttg tggcactggt cttcagtatt cttaccggaa gcgctttagg cattatcggg   1800

tatggtttac tgatggctgt caccggtgcg ctgattgatg aatcgcttgt ggaaaaagcg   1860

aataagttct ggggtatttc ttattggctg cattggatta aacagagacc tggtcaggga   1920

ctgtggatcg gaaccagacc ggtgcatacg tcccagtct                          1959


<210>  8
<211>  652
<212>  PRT
<213>  抗生素 PMC-SA2的氨基酸序列

<400>  8

Ser Asp Pro Val Arg Ile Thr Asn Pro Gly Ala Glu Ser Leu Gly Tyr 
1               5                   10                  15      


Asp Ser Asp Gly His Glu Ile Met Ala Val Asp Ile Tyr Val Asn Pro 
            20                  25                  30          


Pro Arg Val Asp Val Phe His Gly Thr Pro Pro Ala Trp Ser Ser Phe 
        35                  40                  45              


Gly Asn Lys Thr Ile Trp Gly Gly Asn Glu Trp Val Asp Asp Ser Pro 
    50                  55                  60                  


Thr Arg Ser Asp Ile Glu Lys Arg Asp Lys Glu Ile Thr Ala Tyr Lys 
65                  70                  75                  80  


Asn Thr Leu Ser Ala Gln Gln Lys Glu Asn Glu Asn Lys Arg Thr Glu 
                85                  90                  95      


Ala Gly Lys Arg Leu Ser Ala Ala Ile Ala Ala Arg Glu Lys Asp Glu 
            100                 105                 110         


Asn Thr Leu Lys Thr Leu Arg Ala Gly Asn Ala Asp Ala Ala Asp Ile 
        115                 120                 125             


Thr Arg Gln Glu Phe Arg Leu Leu Gln Ala Glu Leu Arg Glu Tyr Gly 
    130                 135                 140                 


Phe Arg Thr Glu Ile Ala Gly Tyr Asp Ala Leu Arg Leu His Thr Glu 
145                 150                 155                 160 


Ser Arg Met Leu Phe Ala Asp Ala Asp Ser Leu Arg Ile Ser Pro Arg 
                165                 170                 175     


Glu Ala Arg Ser Leu Ile Glu Gln Ala Glu Lys Arg Gln Lys Asp Ala 
            180                 185                 190         


Gln Asn Ala Asp Lys Lys Ala Ala Asp Met Leu Ala Glu Tyr Glu Arg 
        195                 200                 205             


Arg Lys Gly Ile Leu Asp Thr Arg Leu Ser Glu Leu Glu Lys Asn Gly 
    210                 215                 220                 


Gly Ala Ala Leu Ala Val Leu Asp Ala Gln Gln Ala Arg Leu Leu Gly 
225                 230                 235                 240 


Gln Gln Thr Arg Asn Asp Arg Ala Ile Ser Glu Ala Arg Asn Lys Leu 
                245                 250                 255     


Ser Ser Val Thr Glu Ser Leu Asn Thr Ala Arg Asn Ala Leu Thr Arg 
            260                 265                 270         


Ala Glu Gln Gln Leu Thr Gln Gln Lys Asn Thr Pro Asp Gly Lys Thr 
        275                 280                 285             


Ile Val Ser Pro Glu Lys Phe Pro Gly Arg Ser Ser Thr Asn His Ser 
    290                 295                 300                 


Ile Val Val Ser Gly Asp Pro Arg Phe Ala Gly Thr Ile Lys Ile Thr 
305                 310                 315                 320 


Thr Ser Ala Val Ile Asp Asn Arg Ala Asn Leu Asn Tyr Leu Leu Ser 
                325                 330                 335     


His Ser Gly Leu Asp Tyr Lys Arg Asn Ile Leu Asn Asp Arg Asn Pro 
            340                 345                 350         


Val Val Thr Glu Asp Val Glu Gly Asp Lys Lys Ile Tyr Asn Ala Glu 
        355                 360                 365             


Val Ala Glu Trp Asp Lys Leu Arg Gln Arg Leu Leu Asp Ala Arg Asn 
    370                 375                 380                 


Lys Ile Thr Ser Ala Glu Ser Ala Val Asn Ser Ala Arg Asn Asn Leu 
385                 390                 395                 400 


Ser Ala Arg Thr Asn Glu Gln Lys His Ala Asn Asp Ala Leu Asn Ala 
                405                 410                 415     


Leu Leu Lys Glu Lys Glu Asn Ile Arg Asn Gln Leu Ser Gly Ile Asn 
            420                 425                 430         


Gln Lys Ile Ala Glu Glu Lys Arg Lys Gln Asp Glu Leu Lys Ala Thr 
        435                 440                 445             


Lys Asp Ala Ile Asn Phe Thr Thr Glu Phe Leu Lys Ser Val Ser Glu 
    450                 455                 460                 


Lys Tyr Gly Ala Lys Ala Glu Gln Leu Ala Arg Glu Met Ala Gly Gln 
465                 470                 475                 480 


Ala Lys Gly Lys Lys Ile Arg Asn Val Glu Glu Ala Leu Lys Thr Tyr 
                485                 490                 495     


Glu Lys Tyr Arg Ala Asp Ile Asn Lys Lys Ile Asn Ala Lys Asp Arg 
            500                 505                 510         


Ala Ala Ile Ala Ala Ala Leu Glu Ser Val Lys Leu Ser Asp Ile Ser 
        515                 520                 525             


Ser Asn Leu Asn Arg Phe Ser Arg Gly Leu Gly Tyr Ala Gly Lys Phe 
    530                 535                 540                 


Thr Ser Leu Ala Asp Trp Ile Thr Glu Phe Gly Lys Ala Val Arg Thr 
545                 550                 555                 560 


Glu Asn Trp Arg Pro Leu Phe Val Lys Thr Glu Thr Ile Ile Ala Gly 
                565                 570                 575     


Asn Ala Ala Thr Ala Leu Val Ala Leu Val Phe Ser Ile Leu Thr Gly 
            580                 585                 590         


Ser Ala Leu Gly Ile Ile Gly Tyr Gly Leu Leu Met Ala Val Thr Gly 
        595                 600                 605             


Ala Leu Ile Asp Glu Ser Leu Val Glu Lys Ala Asn Lys Phe Trp Gly 
    610                 615                 620                 


Ile Ser Tyr Trp Leu His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu 
625                 630                 635                 640 


Trp Ile Gly Thr Arg Pro Val His Thr Ser Gln Ser 
                645                 650         


<210>  9
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA1的人工序列5'-3'

<400>  9
gcgaataagt tctggggtat ttcttattgg ctgcattgga ttaaacagta aataaaatat     60

aagacaggc                                                             69


<210>  10
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA1的人工序列3'-5'

<400>  10
gcctgtctta tattttattt actgtttaat ccaatgcagc caataagaaa taccccagaa     60

cttattcgc                                                             69


<210>  11
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA1的人工序列5'-3'

<400>  11
tggctgcatt ggattaaaca gagacctggt cagggactgt ggatcggata aataaaatat     60

aagacaggc                                                             69


<210>  12
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA1的人工序列3'-5'

<400>  12
gcctgtctta tattttattt atccgatcca cagtccctga ccaggtctct gtttaatcca     60

atgcagcca                                                             69


<210>  13
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA1的人工序列5'-3'

<400>  13
ggtcagggac tgtggatcgg atctcagtcc acgcatgtgc cgagaaccta aataaaatat     60

aagacaggc                                                             69


<210>  14
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA1的人工序列3'-5'

<400>  14
gcctgtctta tattttattt aggttctcgg cacatgcgtg gactgagatc cgatccacag     60

tccctgacc                                                             69


<210>  15
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA2的人工序列5'-3'

<400>  15
gcgaataagt tctggggtat ttcttattgg ctgcattgga ttaaacagta aataaaatat     60

aagacaggc                                                             69


<210>  16
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA2的人工序列3'-5'

<400>  16
gcctgtctta tattttattt actgtttaat ccaatgcagc caataagaaa taccccagaa     60

cttattcgc                                                             69


<210>  17
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA2的人工序列5'-3'

<400>  17
tggctgcatt ggattaaaca gagacctggt cagggactgt ggatcggata aataaaatat     60

aagacaggc                                                             69


<210>  18
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA2的人工序列3'-5'

<400>  18
gcctgtctta tattttattt atccgatcca cagtccctga ccaggtctct gtttaatcca     60

atgcagcca                                                             69


<210>  19
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA2的人工序列5'-3'

<400>  19
ggtcagggac tgtggatcgg aaccagaccg gtgcatacgt cccagtctta aataaaatat     60

aagacaggc                                                             69


<210>  20
<211>  69
<212>  DNA
<213>  构建突变质粒pBHC-PorA2的人工序列3'-5'

<400>  20
gcctgtctta tattttattt aagactggga cgtatgcacc ggtctggttc cgatccacag     60

tccctgacc                                                             69


<210>  21
<211>  174
<212>  PRT
<213>  大肠菌素Ia的水性孔道结构域

<400>  21

Asp Ala Ile Asn Phe Thr Thr Glu Phe Leu Lys Ser Val Ser Glu Lys 
1               5                   10                  15      


Tyr Gly Ala Lys Ala Glu Gln Leu Ala Arg Glu Met Ala Gly Gln Ala 
            20                  25                  30          


Lys Gly Lys Lys Ile Arg Asn Val Glu Glu Ala Leu Lys Thr Tyr Glu 
        35                  40                  45              


Lys Tyr Arg Ala Asp Ile Asn Lys Lys Ile Asn Ala Lys Asp Arg Ala 
    50                  55                  60                  


Ala Ile Ala Ala Ala Leu Glu Ser Val Lys Leu Ser Asp Ile Ser Ser 
65                  70                  75                  80  


Asn Leu Asn Arg Phe Ser Arg Gly Leu Gly Tyr Ala Gly Lys Phe Thr 
                85                  90                  95      


Ser Leu Ala Asp Trp Ile Thr Glu Phe Gly Lys Ala Val Arg Thr Glu 
            100                 105                 110         


Asn Trp Arg Pro Leu Phe Val Lys Thr Glu Thr Ile Ile Ala Gly Asn 
        115                 120                 125             


Ala Ala Thr Ala Val Ala Leu Val Phe Ser Ile Leu Thr Gly Ser Ala 
    130                 135                 140                 


Leu Gly Ile Ile Gly Tyr Gly Leu Leu Met Ala Val Thr Gly Ala Leu 
145                 150                 155                 160 


Asp Glu Ser Leu Val Glu Lys Ala Asn Lys Phe Trp Gly Ile 
                165                 170                 


