б
<110>  㽭ѧ
<120>  һLeg1סLeg1Ӧúҩ
<160>  8     
<170>  PatentIn version 3.5
<210>  1
<212>  PRT
<213>  ˣHomo sapiens
<400>  1
Met Ala Phe Leu Pro Ser Trp Val Cys Val Leu Val Gly Ser Phe Ser 
1               5                   10                  15      
Ala Ser Leu Ala Gly Thr Ser Asn Leu Ser Glu Thr Glu Pro Pro Leu 
            20                  25                  30          
Trp Lys Glu Ser Pro Gly Gln Leu Ser Asp Tyr Arg Val Glu Asn Ser 
        35                  40                  45              
Met Tyr Ile Ile Asn Pro Trp Val Tyr Leu Glu Arg Met Gly Met Tyr 
    50                  55                  60                  
Lys Ile Ile Leu Asn Gln Thr Ala Arg Tyr Phe Ala Lys Phe Ala Pro 
65                  70                  75                  80  
Asp Asn Glu Gln Asn Ile Leu Trp Gly Leu Pro Leu Gln Tyr Gly Trp 
                85                  90                  95      
Gln Tyr Arg Thr Gly Arg Leu Ala Asp Pro Thr Arg Arg Thr Asn Cys 
            100                 105                 110         
Gly Tyr Glu Ser Gly Asp His Met Cys Ile Ser Val Asp Ser Trp Trp 
        115                 120                 125             
Ala Asp Leu Asn Tyr Phe Leu Ser Ser Leu Pro Phe Leu Ala Ala Val 
    130                 135                 140                 
Asp Ser Gly Val Met Gly Ile Ser Ser Asp Gln Val Arg Leu Leu Pro 
145                 150                 155                 160 
Pro Pro Lys Asn Glu Arg Lys Phe Cys Tyr Asp Val Ser Ser Cys Arg 
                165                 170                 175     
Ser Ser Phe Pro Glu Thr Met Asn Lys Trp Asn Thr Phe Tyr Gln Tyr 
            180                 185                 190         
Leu Gln Ser Pro Phe Ser Lys Phe Asp Asp Leu Leu Lys Tyr Leu Trp 
        195                 200                 205             
Ala Ala His Thr Ser Thr Leu Ala Asp Asn Ile Lys Ser Phe Glu Asp 
    210                 215                 220                 
Arg Tyr Asp Tyr Tyr Ser Lys Ala Glu Ala His Phe Glu Arg Ser Trp 
225                 230                 235                 240 
Val Leu Ala Val Asp His Leu Ala Ala Val Leu Phe Pro Thr Thr Leu 
                245                 250                 255     
Ile Arg Ser Tyr Lys Phe Gln Lys Gly Met Pro Pro Arg Ile Leu Leu 
            260                 265                 270         
Asn Thr Asp Val Ala Pro Phe Ile Ser Asp Phe Thr Ala Phe Gln Asn 
        275                 280                 285             
Val Val Leu Val Leu Leu Asn Met Leu Asp Asn Val Asp Lys Ser Ile 
    290                 295                 300                 
Gly Tyr Leu Cys Thr Glu Lys Ser Asn Val Tyr Arg Asp His Ser Glu 
305                 310                 315                 320 
Ser Ser Ser Arg Ser Tyr Gly Asn Asn Ser 
                325                 330
<210>  2
<211>  337
<212>  PRT
<213>  СMus musculus
<400>  2
Met Ala Val Leu Ala Ser Trp Val Trp Val Leu Ala Gly Cys Phe Cys 
1               5                   10                  15      
Ala Ala Val Ala Glu Val Ser Asp Ser Ser Asp Pro Tyr Pro Pro Leu 
            20                  25                  30          
Trp Glu Asp Ser Pro Glu Gln Leu Ser Asp Tyr Met Met Glu Asp Gly 
        35                  40                  45              
Asn Tyr Ile Ile Asn Pro Trp Val Tyr Thr Asp Arg Met Gly Met Tyr 
    50                  55                  60                  
Arg Ile Leu Leu Glu Glu Thr Ala Met Tyr Phe Ala Lys Tyr Gly Pro 
65                  70                  75                  80  
Glu Asn Glu Gln Asn Leu Leu Trp Gly Leu Pro Leu Gln Phe Gly Trp 
                85                  90                  95      
Gln Tyr Gln Ser Gly Arg Leu Ala Asp Pro Thr Gly Met Thr Asp Cys 
            100                 105                 110         
Gly Asn Glu Leu Asn Glu Ser Leu Cys Val Ser Val Asp Ser Trp Trp 
        115                 120                 125             
Ala Asp Ile Asn Tyr Tyr Leu Ser Val Ile Pro Phe Leu Ala Ala Val 
    130                 135                 140                 
Asp Ser Gly Ile Thr Gly Ile Ser Pro Asn Gln Ile Thr Ile Leu Pro 
145                 150                 155                 160 
Pro Pro Lys Asp Gln Met Arg Phe Cys Tyr Asn Val Ser Asp Cys Gln 
                165                 170                 175     
Ser Ala Val Pro Gly Thr Met Asn Arg Trp Arg Asp Phe Phe Gln Tyr 
            180                 185                 190         
Met Gln Leu Asn Ser Ser Asp Phe Asp Gly Leu Leu Asn Tyr Leu Trp 
        195                 200                 205             
Glu Ala His Ala Ser Ser Leu Asp Tyr Pro Thr Ser Ala Phe Gly Asp 
    210                 215                 220                 
Arg Tyr Asn Phe Tyr Ser Glu Lys Glu Ala Asn Phe Glu Glu Asn Trp 
225                 230                 235                 240 
Ala Ile Ala Val Asn Tyr Leu Ala Ala Ala Arg Leu Pro Thr Thr Gln 
                245                 250                 255     
Asn Arg Thr Tyr Ser Phe Gln Arg Gly Leu Pro Pro Arg Val Leu Val 
            260                 265                 270         
Asp Thr Asp Ile Ala Pro Phe Ile Pro Asp Phe Thr Pro Leu Gln Asn 
        275                 280                 285             
Glu Val Leu Val Ser Leu Lys Leu Leu Gly Asp Thr Asp Arg Asn Ser 
    290                 295                 300                 
Gly Ser Leu Ser Leu Thr Leu Trp Glu Asn Leu Met Ser Thr Lys Leu 
305                 310                 315                 320 
Ala Arg Thr Leu Phe Leu Lys Ala Phe Glu Glu Phe Leu Ala Thr Ser 
                325                 330                 335     
Ser 
    
<210>  3
<211>  49
<212>  DNA
<213>  ˣHomo sapiens
<400>  3
atggcttttc ttccttcctg ggtttgtgta ctagttggtt ccttttctgc ttccttagca       60
gggacttcca atctctcaga gacagagccc cctctgtgga aggagagtcc tggtcagctc      120
agtgactaca gggtggagaa cagcatgtac attattaatc cctgggtata ccttgagaga      180
atggggatgt ataaaatcat attgaatcag acagccaggt attttgcaaa atttgcacca      240
gataatgaac agaatatttt atgggggttg cctctgcagt atggctggca atataggaca      300
ggcagattag ctgatccaac ccgaaggaca aactgtggct atgaatctgg agatcatatg      360
tgcatctctg tggacagttg gtgggctgat ttgaattatt ttctgtcttc attacccttt      420
cttgctgcgg ttgattctgg tgtaatgggg atatcatcag accaagtcag gcttttgccc      480
ccacccaaga atgagaggaa gttttgttat gatgtttcta gctgtcgttc atccttccct      540
gagacaatga acaagtggaa caccttttac cagtatttgc agtcaccttt tagtaagttt      600
gatgatctgt tgaagtactt atgggctgca cacacttcaa ccttggcaga taatatcaaa      660
agttttgaag acagatatga ttattattct aaagcagaag cgcattttga gagaagttgg      720
gtactggctg tggatcattt agctgcagtc ctctttccta caaccttgat tagatcatat      780
aagttccaga agggcatgcc accacgaatt cttcttaata ctgatgtagc ccctttcatc      840
agtgacttta ctgcttttca gaatgtagtc ctggttcttc taaatatgct tgacaatgtg      900
gataaatcta taggttatct ttgtacagaa aaatctaatg tatatagaga tcattcggaa      960
tctagctcta gaagttatgg aaataactcc tga                                   993

<210>  4
<211>  1132
<212>  DNA
<213>  СMus musculus
<400>  4
atggctgtcc tggcttcctg ggtctgggta ctggctggct gcttctgtgc agctgtagca       60
gaggtttctg atagctcaga tccatatcct cctttatggg aagacagccc tgagcagttg      120
agtgactaca tgatggagga tgggaactac ataattaatc cttgggtata cactgacaga      180
atggggatgt acagaatctt actggaagag acagctatgt attttgcaaa atatggtcca      240
gaaaatgaac aaaatcttct ttggggattg cctctgcagt ttggctggca gtatcaatca      300
ggtagattag ctgatcccac tggaatgaca gactgtggca atgaacttaa tgagagtctg      360
tgtgtctctg tggacagttg gtgggcagat ataaattatt atctgagtgt gatacctttc      420
cttgctgctg ttgattctgg aataacagga atatcaccaa accaaatcac gatcctgcct      480
ccacccaagg atcagatgag gttttgttat aatgtttctg actgtcaatc tgccgtccct      540
ggaacaatga acagatggag agactttttt cagtacatgc agttgaattc cagtgacttt      600
gatggccttc ttaactactt atgggaagcc catgcctcat ccttggacta tcccaccagt      660
gcctttggag acagatataa tttctattct gaaaaagaag caaattttga ggaaaactgg      720
gctattgctg tgaactattt agcggcagcc cgtcttccta caacccaaaa tagaacatac      780
agctttcaga ggggcctgcc cccacgagtc cttgttgata ctgacatagc cccttttatt      840
cctgacttca ctcctcttca gaacgaagtc ctggtatcac tcaaacttct tggtgatact      900
gacagaaatt caggatcatt atctttgact ctatgggaaa atctcatgag tacaaaactt      960
gcaagaacat tatttctaaa agcctttgaa gagttcctgg caacatcttc ttaa           1014
<210>  5
<211>  364
<212>  PRT
<213>  㣨Danio rerio
<400>  5
Met Ser Glu Met Gly Phe Leu Arg Ser Val Ala Ala Val Leu Leu Leu 
1               5                   10                  15      
Ala Val Phe Ser His Ala Ala Val Val Thr Glu Asn Gly Leu Pro Ile 
            20                  25                  30          
Gln Trp Gly Lys Ala Pro Ser Asp Leu Ser His Leu Pro Ile Ser Asp 
        35                  40                  45              
Thr Gly Val Gln Val Asn Pro Trp Asp Tyr Ser Gln Arg Met Thr Met 
    50                  55                  60                  
Tyr Lys Met Leu Ile Asn Ala Thr Asn Ala Tyr Met Ser Ser Met Gly 
65                  70                  75                  80  
Pro Gly Glu Gln Glu Asn Pro Leu Trp Ser Leu Pro Leu Gln Leu Gly 
                85                  90                  95      
Trp Lys Leu Lys Ser Gly Arg Leu Ala Asp Pro Thr Leu Asp Ser Ser 
            100                 105                 110         
Ser Thr Cys Gly Ser Glu Ala Ser Asp Pro Val Cys Ile Ser Pro Leu 
        115                 120                 125             
Ser Trp Phe Ala Cys Val Asn Tyr Tyr Leu Ser Val Leu Pro Phe Leu 
    130                 135                 140                 
Ala Ala Val Glu Thr Gly Val Val Ser Ser Gly Gly His Gln Val Leu 
145                 150                 155                 160 
Ile Gln Val Pro Ala Glu Val Ala Gln Asp Tyr Cys Ser Ser Tyr Ser 
                165                 170                 175     
Asp Cys Ser Thr Lys His Pro Asn Ala Met Ala Lys Trp His Leu Phe 
            180                 185                 190         
Phe Gln Ser Leu Arg Gln Val Ser Gln Ser Glu Asp Ser Asp Phe Asn 
        195                 200                 205             
Lys Lys Asp Ser Ile Leu Gly Leu Met Trp Ala Ala Glu Glu Glu Ser 
    210                 215                 220                 
Leu Gln Thr Ala Ser Gly Ala Cys Thr Glu Arg Gln Lys Leu Tyr Ser 
225                 230                 235                 240 
Ser Pro Glu Val Ser Phe Gln Gln Ser Trp Leu Asn Ser Ala Ala Phe 
                245                 250                 255     
Val Ser Ala Ala His Phe His Ala Asn Ile Glu Arg Ser Glu Lys Phe 
            260                 265                 270         
Met Ala Pro Leu Pro Ser Arg Val Leu Gln Glu Ala Asp Ser Pro Pro 
        275                 280                 285             
Asn Ile Ala Asp Leu Ser Thr Glu Glu Asn His Thr Leu Tyr Ile Phe 
    290                 295                 300                 
Gly Trp Met Asn Ser Val Asn Gln Leu Leu Gly Gly Ser Leu Val Asn 
305                 310                 315                 320 
Leu Trp Arg Lys Ala Met Cys Ser Ala Gln Ala Arg Glu Lys Gly Gln 
                325                 330                 335     
Ala Leu Leu His Asp Leu Ile Leu Asp Pro Lys Phe Pro Gly Ser Ser 
            340                 345                 350         
Leu Trp Ser Ile Leu Ser Glu Met Ser Thr Ser Cys 
        355                 360                 
<210>  6
<211>  364
<212>  PRT
<213>  㣨Danio rerio
<400> 6
Met Ser Glu Met Gly Phe Leu Arg Ser Val Ala Ala Val Leu Leu Leu 
1               5                   10                  15      
Ala Val Phe Ser His Ala Ala Val Val Thr Glu Asn Gly Leu Pro Ile 
            20                  25                  30          
Gln Trp Arg Lys Ala Pro Ser Asp Leu Ser His Leu Pro Ile Ser Asn 
        35                  40                  45              
Thr Gly Val Gln Val Asn Pro Trp Val Tyr Ser Gln Arg Met Thr Met 
    50                  55                  60                  
Leu Lys Met Val Ile Asn Ala Thr Asn Ala Tyr Met Ser Ser Met Gly 
65                  70                  75                  80  
Pro Gly Glu Gln Glu Asn Pro Leu Trp Ser Leu Pro Leu Gln Leu Gly 
                85                  90                  95      
Trp Lys Leu Lys Ser Gly Arg Leu Ala Asp Pro Thr Pro Asp Ser Ser 
            100                 105                 110         
Ser Thr Cys Gly Ser Glu Ala Ser Asp Pro Val Cys Ile Ser Pro Leu 
        115                 120                 125             
Ser Phe Phe Gly Cys Val Asn Tyr Tyr Leu Ser Val Leu Pro Phe Leu 
    130                 135                 140                 
Ala Ala Val Glu Thr Gly Val Val Ser Ser Gly Gly His Gln Met Leu 
145                 150                 155                 160 
Ile Gln Val Pro Ala Glu Val Ala Gln Asp Tyr Cys Ser Ser Tyr Ser 
                165                 170                 175     
Asp Cys Ser Thr Lys His Pro Asn Thr Met Ala Lys Trp His Leu Phe 
            180                 185                 190         
Phe Gln Ser Leu Arg Gln Val Ser Gln Ser Lys Glu Ser Asp Phe Asn 
        195                 200                 205             
Lys Lys Asp Ser Ile Leu Gly Leu Met Trp Ala Ala Glu Glu Glu Ser 
    210                 215                 220                 
Ile Gln Thr Ala Ser Gly Ala Cys Thr Glu Arg Gln Lys Leu Tyr Ser 
225                 230                 235                 240 
Ser Pro Glu Val Ser Phe Gln Gln Ser Ser Val Asn Leu Gly Ala Phe 
                245                 250                 255     
Ile Ser Ala Ala His Tyr His Ala Ser Ile Glu Arg Ser Gly Lys Phe 
            260                 265                 270         
Met Ser His Leu Pro Ser Arg Val Leu Gln Glu Ala Asp Ser Pro Pro 
        275                 280                 285             
Asn Ile Ala Asp Leu Ser Thr Glu Glu Asn His Ala Leu Tyr Met Leu 
    290                 295                 300                 
Ser Trp Met Asn Ser Ile Asn Gln Leu Leu Gly Gly Ser Leu Val Asp 
305                 310                 315                 320 
Leu Trp Arg Lys Ala Met Cys Ser Ala Gln Ala Arg Glu Lys Gly Gln 
                325                 330                 335     
Ala Phe Leu Asp Asp Leu Ile Leu Asp Pro Lys Phe Pro Gly Ser Ser 
            340                 345                 350         
Leu Trp Ser Ile Ile Cys Val Met Ser Thr Ser Cys 
        355                 360                 
<210>  7
<211>  355
<212>  PRT
<213>  Ovis aries
<400>  7
Met Trp Ser Ser Leu Val Ile Pro Thr Phe Leu Phe Leu Ser Phe Ser 
1               5                   10                  15      
Ser Val Gly Leu Ala Pro Asp Pro Gly Ser Thr Thr His Glu Asn Asp 
            20                  25                  30          
Asn Tyr Pro Pro Phe Trp Gly Gln Thr Asp Gly Asp Ile Ala Glu Phe 
        35                  40                  45              
Pro Val Gln Asn Asn Lys Ile Ile Val Asp Pro Trp Lys Tyr Met Asp 
    50                  55                  60                  
Arg Leu Arg Ile Phe Lys Ile Leu Ile Thr Glu Ser Asn Lys Tyr Phe 
65                  70                  75                  80  
Ala Ser Phe Gly Lys Asn Asp Thr Gly Asn Val Phe Trp Ala Leu Thr 
                85                  90                  95      
Leu Leu Tyr Gly Ser Leu Phe Lys Ser Asp Arg Phe Ser Glu Pro Pro 
            100                 105                 110         
Asn Ser Ser Arg Cys Ala Tyr Glu Ser Gly Val Ser Ser Cys Ile Ser 
        115                 120                 125             
Ile Asn Ser Gly Trp Gly Gly Ile Ser Tyr Tyr Val Val Ile Met Tyr 
    130                 135                 140                 
Phe Leu Ala Ala Ile Glu Ser Glu Phe Leu Gly Asn Leu Pro Tyr Glu 
145                 150                 155                 160 
Val Glu Leu Leu Ser Arg Lys Glu Tyr Arg Ser Asn Phe Cys Tyr Ser 
                165                 170                 175     
Val Glu Glu Cys Arg Ala Ala Tyr Pro Gln Ala Met Asp Ile His Asn 
            180                 185                 190         
Arg Phe Tyr Lys Tyr Leu Gln Ser Arg Lys Ile Val Ser Thr Thr Ser 
        195                 200                 205             
Gly Ile Pro Gln Tyr Asn Thr Asp Glu Asp Thr Ala Ile Phe Lys Met 
    210                 215                 220                 
Trp Ala Ala His Gln Ala Ala Leu Asp Val Ala Lys Pro Lys Phe Arg 
225                 230                 235                 240 
Asp Val Ser Phe Tyr Ser Ser Glu Thr Glu Arg Asp Phe Thr Met Asp 
                245                 250                 255     
Phe Leu Leu Ala Ala Glu Phe Ile Glu Ala Val Leu Tyr Arg Pro Tyr 
            260                 265                 270         
Phe Glu Ser Ser Ala Glu Phe Leu Ala Gly Phe Pro His Arg Leu Leu 
        275                 280                 285             
Thr Asp Gln Asp Arg Asn Val Leu Thr Ser Asn Phe Ser Arg Arg Glu 
    290                 295                 300                 
Lys Ala Leu Ile Thr Val Val Lys Leu Ile Thr Lys Ile Asn Lys Ser 
305                 310                 315                 320 
Thr Gly Gly Leu Leu Leu Thr Ile Trp Lys Lys Leu Met Thr Ser Lys 
                325                 330                 335     
Phe Ala Arg Ala Met Gly Arg Phe Phe Ile Lys Arg Leu Leu Leu Ile 
            340                 345                 350         
Pro Val Glu 
        355 
<210>  8
<211>  317
<212>  PRT
<213>  ţBos taurus
<400>  8
Pro Pro Phe Trp Asp Gln Ile Asp Gly Asp Ile Ala Glu Phe Pro Val 
1               5                   10                  15      
Gln Asn Asn Lys Ile Ile Val Asp Pro Trp Lys Tyr Met Asp Arg Leu 
            20                  25                  30          
Arg Ile Phe Lys Ile Leu Ile Thr Glu Ser Asn Lys Tyr Phe Ala Ser 
        35                  40                  45              
Phe Gly Lys Asn Asn Thr Gly Asn Val Phe Trp Ala Leu Thr Leu Leu 
    50                  55                  60                  
Tyr Gly Arg Leu Phe Lys Thr Asp Arg Phe Ala Glu Pro Pro Asn Ser 
65                  70                  75                  80  
Ser Arg Cys Ala Tyr Glu Ser Gly Ile Ser Ser Cys Ile Ser Ile Asn 
                85                  90                  95      
Ser Gly Trp Gly Gly Ile Ser Tyr Tyr Val Val Met Met Tyr Phe Leu 
            100                 105                 110         
Ala Ala Ile Glu Ser Glu Phe Leu Gly Ser Leu Pro Tyr Glu Val Glu 
        115                 120                 125             
Leu Leu Ser Arg Glu Glu Tyr Arg Ser Asn Phe Cys Tyr Ser Ile Glu 
    130                 135                 140                 
Glu Cys Arg Ala Ala His Pro Gln Ile Met Asp Ile Ala Asn Arg Phe 
145                 150                 155                 160 
Tyr Lys Gln Thr Lys Lys Ile Val Ser Thr Thr Ser Gly Ile Pro Gln 
                165                 170                 175     
Tyr Asp Thr Asp Glu Asp Thr Ala Ile Phe Lys Met Trp Ala Ala His 
            180                 185                 190         
Gln Ala Ala Ile Asp Val Ala Lys Pro Met Phe Ser Asp Val Ser Phe 
        195                 200                 205             
Tyr Ser Ser Glu Thr Glu Arg Asp Phe Thr Met Asp Phe Leu Leu Ala 
    210                 215                 220                 
Ala Glu Phe Phe Glu Ala Ala Leu Tyr Arg Pro Tyr Phe Glu Ser Ser 
225                 230                 235                 240 
Ala Glu Phe Leu Val Gly Phe Pro His Arg Leu Leu Thr Asp Gln Asp 
                245                 250                 255     
Arg Asn Val Leu Met Ser Asn Phe Ser Arg Arg Glu Lys Ala Leu Ile 
            260                 265                 270         
Thr Val Ala Lys Leu Thr Thr Lys Ile Asn Lys Ser Thr Gly Gly Leu 
        275                 280                 285             
Leu Leu Thr Ile Trp Lys Lys Leu Met Thr Ser Lys Phe Ala Arg Ala 
    290                 295                 300                 
Thr Gly Arg Phe Phe Ile Lys Arg Leu Leu Leu Ile Pro 
305                 310                 315  

