                         SEQUENCE LISTING

<110>  Quantum-Si Incorporated
 
<120>  POLYMERIZING ENZYMES FOR SEQUENCING REACTIONS

<130>  R0708.70022WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/436,410
<151>  2016-12-19

<160>  539   

<170>  PatentIn version 3.5

<210>  1
<211>  575
<212>  PRT
<213>  Bacillus phage phi29

<400>  1

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  2
<211>  572
<212>  PRT
<213>  Bacteriophage M2Y

<400>  2

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 
        195                 200                 205             


Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 
        355                 360                 365             


Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 
                405                 410                 415     


Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 
    530                 535                 540                 


Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  3
<211>  830
<212>  PRT
<213>  Lucilia cuprina

<400>  3

Met Ala Arg Lys Arg Pro Ile Arg Ile Thr Lys Asn Asp Arg Ala Glu 
1               5                   10                  15      


Tyr Lys Arg Leu Ser Lys Asn Ala Lys Ser Lys Leu Asn Arg Thr Val 
            20                  25                  30          


Lys Asn Tyr Gly Ile Asp Leu Ser Asn Asp Val Asp Ile Pro Lys Leu 
        35                  40                  45              


Ser Asp Phe Lys Thr Arg Lys Glu Phe Asn Asp Trp Lys Gln Lys Ile 
    50                  55                  60                  


Thr Ser Phe Thr Ser Arg Ser Asn Gln Glu Tyr Gln Phe Arg Lys Asn 
65                  70                  75                  80  


Glu Tyr Gly Val Val Ala Ser Val Lys Glu Leu Asn Glu Ile Lys Arg 
                85                  90                  95      


Asn Thr Lys Lys Ala Gln Lys Ile Ala Lys Glu Lys Ile Asp Lys Ala 
            100                 105                 110         


Met Lys Leu Asp Phe Tyr Val Glu Gly Glu Arg Gln Gly Lys Val Lys 
        115                 120                 125             


Asp Arg Ile Lys Leu Met Lys Lys Glu Glu Val Ala Gly Val Ser Val 
    130                 135                 140                 


Pro Val Asp Phe Asp Phe Asp Lys Ile Gln Thr Arg Lys Arg Leu Glu 
145                 150                 155                 160 


Asp Lys Ala Gly Phe Met Glu Glu Arg Ala Thr Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Lys Asp Ile Gln Met Lys Glu Asn Phe Ile Ser Met Ile Glu Gln 
            180                 185                 190         


Gly Phe Asn Ser Asp Ala Asp Glu Val Ile Lys Lys Leu Lys Lys Ile 
        195                 200                 205             


Pro Pro Asp Asp Phe Val Glu Leu Thr Ile Val Thr Asp Glu Ile Asp 
    210                 215                 220                 


Phe Arg Asn Tyr Gly Ser Lys Asn Glu Gly Gly Ile Asn Asp Glu Asp 
225                 230                 235                 240 


Lys Leu Glu Glu Leu Asn Asn Thr Leu Asn Asp Tyr Phe Asn Glu Thr 
                245                 250                 255     


Thr Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu 
            260                 265                 270         


Ile Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe 
        275                 280                 285             


Met Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asn Leu 
    290                 295                 300                 


Lys Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr 
305                 310                 315                 320 


Thr Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile 
                325                 330                 335     


Ser Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp 
            340                 345                 350         


Gly Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu 
        355                 360                 365             


Pro Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu 
    370                 375                 380                 


Lys Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile 
385                 390                 395                 400 


Asp Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala 
                405                 410                 415     


Glu Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn 
            420                 425                 430         


Gly Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr 
        435                 440                 445             


Glu Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg 
    450                 455                 460                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Thr 
465                 470                 475                 480 


Lys Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Val Asn Ser Leu Tyr 
                485                 490                 495     


Pro Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro 
            500                 505                 510         


Phe Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln 
        515                 520                 525             


Lys Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile 
    530                 535                 540                 


Gln Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser 
545                 550                 555                 560 


Ser Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp 
                565                 570                 575     


Glu Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys 
            580                 585                 590         


Gly Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp 
        595                 600                 605             


Lys Trp Met Leu Val Lys Asn Met Ser Ala Gly Ala Lys Lys Ala Ile 
    610                 615                 620                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro 
625                 630                 635                 640 


Asp Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly 
                645                 650                 655     


Phe Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val 
            660                 665                 670         


Gly Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala 
        675                 680                 685             


Gln Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His 
    690                 695                 700                 


Leu Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp 
705                 710                 715                 720 


Asp Val Leu Gly Tyr Trp Lys Lys Glu Gly Gln Phe Lys Gln Gly Lys 
                725                 730                 735     


Phe Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val 
            740                 745                 750         


Arg Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Ile Lys 
        755                 760                 765             


Thr Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys 
    770                 775                 780                 


Cys Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn 
785                 790                 795                 800 


Phe Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val 
                805                 810                 815     


Tyr Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys 
            820                 825                 830 


<210>  4
<211>  589
<212>  PRT
<213>  Lucilia cuprina (mod.)

<400>  4

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 
            20                  25                  30          


Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 
        35                  40                  45              


Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 
65                  70                  75                  80  


Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 
                85                  90                  95      


Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 
            100                 105                 110         


Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 
145                 150                 155                 160 


Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 
            180                 185                 190         


Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr Glu 
        195                 200                 205             


Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Thr Lys 
225                 230                 235                 240 


Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Val Asn Ser Leu Tyr Pro 
                245                 250                 255     


Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe 
            260                 265                 270         


Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys 
        275                 280                 285             


Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln 
    290                 295                 300                 


Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser 
305                 310                 315                 320 


Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu 
                325                 330                 335     


Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly 
            340                 345                 350         


Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp Lys 
        355                 360                 365             


Trp Met Leu Val Lys Asn Met Ser Ala Gly Ala Lys Lys Ala Ile Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly Phe 
                405                 410                 415     


Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val Gly 
            420                 425                 430         


Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala Gln 
        435                 440                 445             


Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His Leu 
    450                 455                 460                 


Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp Asp 
465                 470                 475                 480 


Val Leu Gly Tyr Trp Lys Lys Glu Gly Gln Phe Lys Gln Gly Lys Phe 
                485                 490                 495     


Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val Arg 
            500                 505                 510         


Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Ile Lys Thr 
        515                 520                 525             


Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys Cys 
    530                 535                 540                 


Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn Phe 
545                 550                 555                 560 


Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val Tyr 
                565                 570                 575     


Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys 
            580                 585                 


<210>  5
<211>  573
<212>  PRT
<213>  Enterococcus faecium

<400>  5

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  6
<211>  592
<212>  PRT
<213>  Bacillus phage VMY22

<400>  6

Met Ala Thr Lys Lys Arg Lys Ala Tyr Ser Cys Asp Phe Glu Ala Thr 
1               5                   10                  15      


Thr Ser Thr Tyr Ser Glu Thr Glu Thr Arg Val Trp Ala Tyr Gly Trp 
            20                  25                  30          


Met Glu Ile Gly Asn Thr Ser His Phe Asn Ile Gly Asp Asn Leu Asp 
        35                  40                  45              


Glu Phe Met Leu Trp Thr Ser Lys Glu Cys Ala Asp Leu Tyr Phe His 
    50                  55                  60                  


Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys 
65                  70                  75                  80  


Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys Thr Phe Asp Thr Val 
                85                  90                  95      


Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala Ile His His Glu Gly 
            100                 105                 110         


Lys Gly Thr Thr Gln Ile Phe Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Val Leu Lys Gly Asp 
    130                 135                 140                 


Ile Asp Tyr Asn Leu His Arg Asp Glu Asn His Val Ile Thr Ser Glu 
145                 150                 155                 160 


Glu Phe Thr Tyr Ile Lys His Asp Ile Glu Ile Val Ala Arg Ala Leu 
                165                 170                 175     


Asp Ile Gln Ile Asn Gln Gln Gly Leu Val Lys Met Thr Asn Gly Ala 
            180                 185                 190         


Asp Ser Met Asp His Phe Ile Lys Ser Leu Asp Lys Lys Lys Lys Val 
        195                 200                 205             


Ala Glu Arg Ile Tyr Asn Gln Tyr Phe Pro Lys Met Ser Ile Ala Met 
    210                 215                 220                 


Asp Ser Ile Phe Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Val Asn 
225                 230                 235                 240 


Pro Lys Phe Lys Gly Gln Glu Val Gly Glu Gly Met Val Phe Asp Val 
                245                 250                 255     


Asn Ser Leu Tyr Pro Ser Val Met Tyr Tyr Lys Pro Leu Pro Trp Gly 
            260                 265                 270         


Lys Pro Val Pro Phe Val Gly Lys Tyr Glu Glu Asp Pro Asp Phe Pro 
        275                 280                 285             


Leu Tyr Ile Cys His Ile Lys Thr Gly Phe Val Leu Lys Glu Gly His 
    290                 295                 300                 


Ile Pro Thr Ile Gln Ile Lys Lys Asn Pro Ile Phe Gln Glu Asn Glu 
305                 310                 315                 320 


Tyr Leu Glu Thr Ser Gly Gly Ala Pro Val Asp Leu His Val Thr Asn 
                325                 330                 335     


Val Asp Leu Glu Leu Ile Lys Glu His Tyr Glu Leu Tyr Asp Thr Glu 
            340                 345                 350         


Tyr Val Gly Gly Trp Lys Phe Arg Gln Gln Thr Gly Ile Phe Asn Asn 
        355                 360                 365             


Phe Ile Asp Tyr Trp Met Lys Ile Lys Thr Asp Pro Lys Ser Thr Pro 
    370                 375                 380                 


Ala Ile Val Thr Leu Ala Lys Leu Gln Leu Asn Ser Leu Tyr Gly Lys 
385                 390                 395                 400 


Phe Ala Ser His Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp 
                405                 410                 415     


Asp Gly Ser Thr Ala Phe Lys Lys Gly Leu Pro Lys Ser Lys Asp Pro 
            420                 425                 430         


Val Tyr Thr Pro Ala Gly Ala Phe Ile Thr Ala Trp Ala Arg His Met 
        435                 440                 445             


Thr Ile Thr Thr Ala Gln Lys Val Tyr Asp Arg Ile Leu Tyr Cys Asp 
    450                 455                 460                 


Thr Asp Ser Ile His Ile Leu Gly Ile Asp Ile Pro Glu Ala Ile Lys 
465                 470                 475                 480 


Asn Asp Ile His Gln Lys Glu Leu Gly Lys Trp Ala Phe Glu Cys Met 
                485                 490                 495     


Phe Lys Arg Ala Lys Phe Val Arg Gln Lys Thr Tyr Val Glu Asp Met 
            500                 505                 510         


Tyr Ala Lys Phe Met Ser Tyr Trp Glu Asp Gly Glu Leu Asn Tyr Met 
        515                 520                 525             


Leu Lys Glu Cys Val Lys Glu Glu Ala Thr Ala Arg Leu Leu Asn Val 
    530                 535                 540                 


Lys Cys Ala Gly Met Pro Gln Ala Val Lys Lys Phe Val Thr Phe Arg 
545                 550                 555                 560 


Thr Phe Ala Val Gly Phe Thr Ser Asp Thr Gly Lys Leu Lys Pro Lys 
                565                 570                 575     


His Val Lys Gly Gly Gln Ile Leu Val Asp Val Pro Phe Thr Ile Lys 
            580                 585                 590         


<210>  7
<211>  578
<212>  PRT
<213>  Bacillus phage GA-1

<400>  7

Met Ala Arg Ser Val Tyr Val Cys Asp Phe Glu Thr Thr Thr Asp Pro 
1               5                   10                  15      


Glu Asp Cys Arg Leu Trp Ala Trp Gly Trp Met Asp Ile Tyr Asn Thr 
            20                  25                  30          


Asp Lys Trp Ser Tyr Gly Glu Asp Ile Asp Ser Phe Met Glu Trp Ala 
        35                  40                  45              


Leu Asn Ser Asn Ser Asp Ile Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ser Phe Ile Leu Pro Trp Trp Leu Arg Asn Gly Tyr Val His Thr Glu 
65                  70                  75                  80  


Glu Asp Arg Thr Asn Thr Pro Lys Glu Phe Thr Thr Thr Ile Ser Gly 
                85                  90                  95      


Met Gly Gln Trp Tyr Ala Val Asp Val Cys Ile Asn Thr Arg Gly Lys 
            100                 105                 110         


Asn Lys Asn His Val Val Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Lys Val Glu Gln Ile Ala Lys Gly Phe Gly Leu Pro Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr Lys Lys Tyr Arg Pro Val Gly Tyr Val Met Asp Asp 
145                 150                 155                 160 


Asn Glu Ile Glu Tyr Leu Lys His Asp Leu Leu Ile Val Ala Leu Ala 
                165                 170                 175     


Leu Arg Ser Met Phe Asp Asn Asp Phe Thr Ser Met Thr Val Gly Ser 
            180                 185                 190         


Asp Ala Leu Asn Thr Tyr Lys Glu Met Leu Gly Val Lys Gln Trp Glu 
        195                 200                 205             


Lys Tyr Phe Pro Val Leu Ser Leu Lys Val Asn Ser Glu Ile Arg Lys 
    210                 215                 220                 


Ala Tyr Lys Gly Gly Phe Thr Trp Val Asn Pro Lys Tyr Gln Gly Glu 
225                 230                 235                 240 


Thr Val Tyr Gly Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala 
                245                 250                 255     


Met Met Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys 
            260                 265                 270         


Gly Glu Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val 
        275                 280                 285             


Arg Cys Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile 
    290                 295                 300                 


Lys Gly Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly 
305                 310                 315                 320 


Asp Glu Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile 
                325                 330                 335     


Lys Lys His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met 
            340                 345                 350         


Phe Lys Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met 
        355                 360                 365             


Glu Ile Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Leu Asp Glu Asn Gly Val Leu Lys Phe 
                405                 410                 415     


Arg Lys Gly Glu Leu Lys Glu Arg Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Cys Phe Ile Thr Ala Tyr Ala Arg Glu Asn Ile Leu Ser Asn Ala Gln 
        435                 440                 445             


Lys Leu Tyr Pro Arg Phe Ile Tyr Ala Asp Thr Asp Ser Ile His Val 
    450                 455                 460                 


Glu Gly Leu Gly Glu Val Asp Ala Ile Lys Asp Val Ile Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Asp His Glu Ala Thr Phe Gln Arg Ala Arg Tyr 
                485                 490                 495     


Val Arg Gln Lys Thr Tyr Phe Ile Glu Thr Thr Trp Lys Glu Asn Asp 
            500                 505                 510         


Lys Gly Lys Leu Val Val Cys Glu Pro Gln Asp Ala Thr Lys Val Lys 
        515                 520                 525             


Pro Lys Ile Ala Cys Ala Gly Met Ser Asp Ala Ile Lys Glu Arg Ile 
    530                 535                 540                 


Arg Phe Asn Glu Phe Lys Ile Gly Tyr Ser Thr His Gly Ser Leu Lys 
545                 550                 555                 560 


Pro Lys Asn Val Leu Gly Gly Val Val Leu Met Asp Tyr Pro Phe Ala 
                565                 570                 575     


Ile Lys 
        


<210>  8
<211>  566
<212>  PRT
<213>  Actinomyces phage AV-1

<400>  8

Met Val Arg Gln Ser Thr Ile Ala Ser Pro Ala Arg Gly Gly Val Arg 
1               5                   10                  15      


Arg Ser His Lys Lys Val Pro Ser Phe Cys Ala Asp Phe Glu Thr Thr 
            20                  25                  30          


Thr Asp Glu Asp Asp Cys Arg Val Trp Ser Trp Gly Ile Ile Gln Val 
        35                  40                  45              


Gly Lys Leu Gln Asn Tyr Val Asp Gly Ile Ser Leu Asp Gly Phe Met 
    50                  55                  60                  


Ser His Ile Ser Glu Arg Ala Ser His Ile Tyr Phe His Asn Leu Ala 
65                  70                  75                  80  


Phe Asp Gly Thr Phe Ile Leu Asp Trp Leu Leu Lys His Gly Tyr Arg 
                85                  90                  95      


Trp Thr Lys Glu Asn Pro Gly Val Lys Glu Phe Thr Ser Leu Ile Ser 
            100                 105                 110         


Arg Met Gly Lys Tyr Tyr Ser Ile Thr Val Val Phe Glu Thr Gly Phe 
        115                 120                 125             


Arg Val Glu Phe Arg Asp Ser Phe Lys Lys Leu Pro Met Ser Val Ser 
    130                 135                 140                 


Ala Ile Ala Lys Ala Phe Asn Leu His Asp Gln Lys Leu Glu Ile Asp 
145                 150                 155                 160 


Tyr Glu Lys Pro Arg Pro Ile Gly Tyr Ile Pro Thr Glu Gln Glu Lys 
                165                 170                 175     


Arg Tyr Gln Arg Asn Asp Val Ala Ile Val Ala Gln Ala Leu Glu Val 
            180                 185                 190         


Gln Phe Ala Glu Lys Met Thr Lys Leu Thr Ala Gly Ser Asp Ser Leu 
        195                 200                 205             


Ala Thr Tyr Lys Lys Met Thr Gly Lys Leu Phe Ile Arg Arg Phe Pro 
    210                 215                 220                 


Ile Leu Ser Pro Glu Ile Asp Thr Glu Ile Arg Lys Ala Tyr Arg Gly 
225                 230                 235                 240 


Gly Phe Thr Tyr Ala Asp Pro Arg Tyr Ala Lys Lys Leu Asn Gly Lys 
                245                 250                 255     


Gly Ser Val Tyr Asp Val Asn Ser Leu Tyr Pro Ser Val Met Arg Thr 
            260                 265                 270         


Ala Leu Leu Pro Tyr Gly Glu Pro Ile Tyr Ser Glu Gly Ala Pro Arg 
        275                 280                 285             


Thr Asn Arg Pro Leu Tyr Ile Ala Ser Ile Thr Phe Thr Ala Lys Leu 
    290                 295                 300                 


Lys Pro Asn His Ile Pro Cys Ile Gln Ile Lys Lys Asn Leu Ser Phe 
305                 310                 315                 320 


Asn Pro Thr Gln Tyr Leu Glu Glu Val Lys Glu Pro Thr Thr Val Val 
                325                 330                 335     


Ala Thr Asn Ile Asp Ile Glu Leu Trp Lys Lys His Tyr Asp Phe Lys 
            340                 345                 350         


Ile Tyr Ser Trp Asn Gly Thr Phe Glu Phe Arg Gly Ser His Gly Phe 
        355                 360                 365             


Phe Asp Thr Tyr Val Asp His Phe Met Glu Ile Lys Lys Asn Ser Thr 
    370                 375                 380                 


Gly Gly Leu Arg Gln Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly 
385                 390                 395                 400 


Lys Phe Ala Thr Asn Pro Asp Ile Thr Gly Lys His Pro Thr Leu Lys 
                405                 410                 415     


Asp Asn Arg Val Ser Leu Val Met Asn Glu Pro Glu Thr Arg Asp Pro 
            420                 425                 430         


Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Tyr Ala Arg Lys Lys 
        435                 440                 445             


Thr Ile Ser Ala Ala Gln Asp Asn Tyr Glu Thr Phe Ala Tyr Ala Asp 
    450                 455                 460                 


Thr Asp Ser Leu His Leu Ile Gly Pro Thr Thr Pro Pro Asp Ser Leu 
465                 470                 475                 480 


Trp Val Asp Pro Val Glu Leu Gly Ala Trp Lys His Glu Ser Ser Phe 
                485                 490                 495     


Thr Lys Ser Val Tyr Ile Arg Ala Lys Gln Tyr Ala Glu Glu Ile Gly 
            500                 505                 510         


Gly Lys Leu Asp Val His Ile Ala Gly Met Pro Arg Asn Val Ala Ala 
        515                 520                 525             


Thr Leu Thr Leu Glu Asp Met Leu His Gly Gly Thr Trp Asn Gly Lys 
    530                 535                 540                 


Leu Ile Pro Val Arg Val Pro Gly Gly Thr Val Leu Lys Asp Thr Thr 
545                 550                 555                 560 


Phe Thr Leu Lys Ile Asp 
                565     


<210>  9
<211>  593
<212>  PRT
<213>  Candidatus Moranbacteria

<400>  9

Met Lys Leu Lys Ser Lys Tyr Val Ala Asp Phe Glu Ala Thr Gly Glu 
1               5                   10                  15      


Glu Gln Tyr Lys Ile Asp Gly Ser Thr His Val Trp Ala Val Gly Val 
            20                  25                  30          


Ile Asp Ile Glu Thr Glu Glu Thr Val Leu Ile Ser Asn Asp Ile Ala 
        35                  40                  45              


Asp Phe Met Asn Trp Leu Ser Lys Asp Asn His Asn His Lys Asn Lys 
    50                  55                  60                  


Glu Val Phe Phe His Asn Leu Lys Tyr Asp Gly Asp Phe Ile Val Lys 
65                  70                  75                  80  


Phe Leu Leu Glu Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr 
                85                  90                  95      


Ser Asn Glu Phe Ser Thr Leu Ile Ser Asp Thr Gly Thr Trp Tyr Glu 
            100                 105                 110         


Ile Lys Ile Cys Phe His Ala Leu Lys Thr Arg Lys Val Glu Val Lys 
        115                 120                 125             


Ile His Asp Ser Tyr Lys Leu Leu Pro Phe Ser Glu Glu Lys Ile Ala 
    130                 135                 140                 


Lys Ala Phe Lys Leu Thr Val Ser Lys Gly Glu Ile Asp Tyr Asp Arg 
145                 150                 155                 160 


Tyr Arg Pro Val Gly Tyr Gln Leu Gln Glu Tyr Glu Val Asp Tyr Leu 
                165                 170                 175     


Lys Thr Asp Leu Leu Ile Met Ala Gln Ala Leu Lys Val Gln Met Asn 
            180                 185                 190         


Lys Gly Leu Thr Lys Met Thr Ile Gly Ser Asn Ala Leu Ala Asp Tyr 
        195                 200                 205             


Lys Gln Arg Ile Ser Lys Asp Lys Phe Lys Tyr Leu Phe Pro Val Leu 
    210                 215                 220                 


Asp Asn Ile Ile Asp Ala Asp Leu Arg His Ala Tyr Arg Gly Gly His 
225                 230                 235                 240 


Thr Tyr Leu Gln Pro Phe Tyr Ala Asn Lys Ile Leu Glu Asn Val His 
                245                 250                 255     


Ser Tyr Asp Lys Asn Ser Met His Pro Ser Gln Met Lys Asn Met Pro 
            260                 265                 270         


Met Pro Tyr Gly Ile Pro Val Tyr Tyr Glu Gly Glu Tyr Lys Asn Asp 
        275                 280                 285             


Pro Asp Tyr Pro Leu Phe Ile Gln Ser Ile Glu Ile Asp Cys Lys Val 
    290                 295                 300                 


Lys Lys Gly Tyr Leu Pro Thr Ile Gln Pro Arg Asn Ala Phe Arg Phe 
305                 310                 315                 320 


Ala Thr Thr Glu Phe Leu Glu Asp Thr Lys Gly Glu Pro Ile Gln Leu 
                325                 330                 335     


Phe Val Thr Ser Ile Asp Leu Met Leu Ile Leu Glu His Tyr Asp Ile 
            340                 345                 350         


His Tyr Ile Gln Tyr Leu Glu Gly Phe Lys Phe Arg Ser His Ile Gly 
        355                 360                 365             


Leu Phe Asp Glu Tyr Ile Asp Tyr Trp Tyr His Ile Lys Glu Thr Asn 
    370                 375                 380                 


Thr Gly Pro Leu Arg Glu Ile Ala Lys Leu Met Leu Asn Asn Leu Tyr 
385                 390                 395                 400 


Gly Lys Phe Gly Thr Asn Pro Ile Arg Ala Arg Lys Glu Pro Ile Tyr 
                405                 410                 415     


Asp Lys Thr Lys Gly Ala Val Tyr Val Asn Leu Pro Ala Glu Glu Gly 
            420                 425                 430         


Asp Ala Val Tyr Ile Pro Met Ala Cys Phe Ile Thr Ala Tyr Ser Arg 
        435                 440                 445             


Tyr Asp Leu Ile Ser Thr Ala Gln Lys Phe Tyr Lys Asn Val Val Tyr 
    450                 455                 460                 


Met Asp Thr Asp Ser Ile Lys Phe Tyr Gly Ile Ser Arg Glu Val Ile 
465                 470                 475                 480 


Glu Ala Gln Ile Glu Val His Asp Thr Lys Ile Gly Ala Trp Lys Tyr 
                485                 490                 495     


Glu Gly Thr Ala Lys Met Phe Lys Ala Leu Arg Pro Lys Thr Tyr Ala 
            500                 505                 510         


Tyr Ile Asp Glu Asn Asp Glu Leu Asp Val Lys Cys Ala Gly Leu Pro 
        515                 520                 525             


Lys Lys Ala Lys Lys Asp Ile Thr Phe Asp Thr Phe Gln Tyr Gly Phe 
    530                 535                 540                 


Val Ser Lys Glu Lys Leu Glu Ile Lys Arg Val Lys Gly Gly Thr Ile 
545                 550                 555                 560 


Leu Leu Lys Thr Lys Phe Glu Ile Lys Lys Gln Val Asp Asn Lys His 
                565                 570                 575     


Ile Asp Thr Glu Tyr Phe Glu Asp Glu Asp Ile Asp Ile Phe Asn Gln 
            580                 585                 590         


Leu 
    


<210>  10
<211>  669
<212>  PRT
<213>  Bacillus phage MG-B1

<400>  10

Met Lys Lys Lys Arg Thr Lys Thr Lys Ile Lys Thr Tyr Ala Cys Asp 
1               5                   10                  15      


Phe Glu Thr Asn Thr Glu Ala Trp Leu His Glu Asp Lys Leu Arg Asp 
            20                  25                  30          


Glu Leu Lys Thr Lys Glu Glu Asn Pro Glu Leu Trp Arg Lys Arg Glu 
        35                  40                  45              


Ala Trp Lys Leu His Thr Gly Gly Asp Lys Ala Phe Val Trp Ser Trp 
    50                  55                  60                  


Gly Gly Thr Glu Ile Arg Glu Asp Met Ser Phe Lys Gly Glu Leu Asp 
65                  70                  75                  80  


Asn Phe Val Val Gly Lys Gly Ile Ser Glu Tyr Val Asp Trp Met Leu 
                85                  90                  95      


Asp Gly Ser Lys Asn Val Trp Phe His Asn Leu Lys Phe Asp Gly Ser 
            100                 105                 110         


Phe Ile Ala Val Glu Leu Leu Arg Arg Gly Phe Lys Phe Thr Phe Asp 
        115                 120                 125             


Arg Asn Pro Ala Ile Gly Glu Phe Thr Gly Leu Ile Asp Gly Lys Lys 
    130                 135                 140                 


Met Trp Phe Glu Leu Ile Ile Cys Lys Glu Gly Lys Arg Gly Gly Arg 
145                 150                 155                 160 


Gln Phe Ile Thr Ile Lys Asp Ser Leu Lys Lys Val Pro Phe Gly Leu 
                165                 170                 175     


Arg Val Ala Ala Met Ala Phe Gly Leu Asp Val Phe Lys Asp Asp Met 
            180                 185                 190         


Asp Tyr Asp Val Ile Arg Glu Pro Phe Glu Pro Ile Gly Glu Ala Asp 
        195                 200                 205             


Tyr Lys Tyr Leu Lys Lys Asp Val Glu Ile Thr Ala Lys Ile Ile His 
    210                 215                 220                 


Tyr Gln Val Phe Gln Ser Gly Leu Lys Lys Thr Thr Ile Gly Ser Asp 
225                 230                 235                 240 


Ala Leu Asn Glu Phe Lys Ser Thr Val Gly Gly Asp Lys Gly Phe Lys 
                245                 250                 255     


Glu Ile Phe Pro Val Met Asp Phe Asp Thr Asp Ser Phe Ile Arg Lys 
            260                 265                 270         


Ser Tyr Phe Gly Gly Val Thr Gln Val Lys Pro Gly Met Glu Gly Lys 
        275                 280                 285             


Leu Ile Gly Glu Gly Ser Val Phe Asp Ile Val Ser Met Tyr Pro Trp 
    290                 295                 300                 


Val Gln Tyr Thr Lys Leu Leu Pro Tyr Gly Leu Pro Ile Glu Tyr Asn 
305                 310                 315                 320 


Gly Glu Tyr Thr Tyr Asp Glu Glu Tyr Pro Leu Tyr Val Gln Gln Val 
                325                 330                 335     


Ser Phe Ser Phe Val Val Lys Asp Asn Met Leu Pro Thr Ile Gln Leu 
            340                 345                 350         


Lys Lys Gln Asn Val Glu Phe Asn Tyr Asn Glu Ala Asp Asp Val Arg 
        355                 360                 365             


Lys Phe Asn Gly Arg Glu Phe Gln Lys Thr Ser Tyr Gly Glu Ile Val 
    370                 375                 380                 


Thr Met Tyr Val Thr Asn Val Gln Trp Glu Gln Ile Gln Lys His Tyr 
385                 390                 395                 400 


Trp Leu Asp Asp Leu His Phe His Lys Gly Met Met Phe Lys Gly Lys 
                405                 410                 415     


Ile Gly Leu Phe Lys Glu His Ile Asp Lys Trp Leu Lys Val Lys Lys 
            420                 425                 430         


Gln Ala Asn Asp Asp Gly Asn Asp Ala Leu Lys Ser Leu Ala Lys Leu 
        435                 440                 445             


Met Leu Asn Ser Pro Tyr Gly Lys Phe Gly Thr Asn Thr Ile Arg Leu 
    450                 455                 460                 


Asn Val Glu Pro Phe Leu Trp Glu Asp Asp Glu Ser Leu Gly Phe Arg 
465                 470                 475                 480 


Val Glu Asp Asp Asp Pro Pro Pro Ala Asp Pro Ile Tyr Thr Ala Tyr 
                485                 490                 495     


Ala Ser Phe Val Thr Ala Tyr Ala Arg Glu Glu Leu Val Ser Thr Ile 
            500                 505                 510         


Met Met Cys Tyr Asp Arg Phe Val Tyr Cys Asp Thr Asp Ser Ile His 
        515                 520                 525             


Leu Ile Gly Thr Glu Ile Pro Glu Gly Ile Lys His Lys Ile Gly Gly 
    530                 535                 540                 


Asp Leu Gly Asp Trp Glu Pro Glu Ser Glu Phe Lys Leu Ala Lys Phe 
545                 550                 555                 560 


His Arg Ala Lys Thr Tyr Cys Glu Met Val Tyr Ala Lys Lys Val Met 
                565                 570                 575     


Lys Lys Asp Arg Trp Gly Asp Val Val Glu Ser Leu Lys His Cys Ser 
            580                 585                 590         


Lys Glu Glu Trp Gly Thr Leu Pro Gln Asp Gln Lys Thr Leu Asp Lys 
        595                 600                 605             


Asn Leu Lys Cys Ala Gly Leu Gln Gly His Leu Lys Asp Tyr Val Ser 
    610                 615                 620                 


Phe Glu Glu Phe Glu Ile Gly Leu Lys Ile Asn Pro Glu Val Asn Lys 
625                 630                 635                 640 


Asp Ile Met Gly Lys Pro Leu Gly Lys Leu Met Pro Cys Gln Val Lys 
                645                 650                 655     


Gly Gly Thr Leu Leu Lys Val Arg Lys Phe Ser Leu Asn 
            660                 665                 


<210>  11
<211>  572
<212>  PRT
<213>  Eggerthella sp.

<400>  11

Met Asn Glu Tyr Ile Ser Asp Phe Glu Thr Gln Lys Asp Pro Asp Thr 
1               5                   10                  15      


Gly Val Met Ser Val Trp Ala Trp Ser Ile Val Asp Val Asn Asp Leu 
            20                  25                  30          


Ser Asn Ile Gln Tyr Gly Asn Asn Ile Glu Ser Trp Leu Ser Ala Ile 
        35                  40                  45              


Gln Gly Leu Pro Asn Gly Ser Leu Ile Gly Phe His Asn Leu Lys Phe 
    50                  55                  60                  


Asp Gly Ser Tyr Ile Leu Ser Tyr Leu Leu Gly Val Ala Lys Trp Glu 
65                  70                  75                  80  


Tyr Asn Asp Lys Pro Lys Ala Arg Lys Ala Lys Thr Val Glu Cys Leu 
                85                  90                  95      


Ile Ser Ser Ile Gly Val His Tyr Asn Tyr Arg Ile Asn Phe Thr Lys 
            100                 105                 110         


Arg Lys Tyr Val Lys Ile Tyr Asp Thr Leu Lys Ile Phe Asn Met Ser 
        115                 120                 125             


Val Ser Gln Ile Ala Lys Ser Phe Gly Ile Lys Glu Gln Lys Gly Ser 
    130                 135                 140                 


Ile Asp Tyr Ala Ile Phe Arg Gly Tyr Asn Tyr Thr Met Thr Pro Lys 
145                 150                 155                 160 


Glu Val Glu Tyr Ile Thr Asn Asp Val Lys Ile Val Ala Lys Ala Ile 
                165                 170                 175     


Lys Gln Phe Arg Asn Glu Gly His Glu Arg Asn Thr Ile Ala Ser Asn 
            180                 185                 190         


Ala Met Arg Tyr Tyr Lys Lys Asn Ser Tyr Tyr Ser Asn Tyr Glu Phe 
        195                 200                 205             


Leu Thr Tyr Phe Pro His Leu Asp Asp Asp Leu Tyr His Leu Leu Lys 
    210                 215                 220                 


Arg Ala Tyr Lys Gly Gly Tyr Cys Tyr Val Asn Pro Lys Phe Lys Gly 
225                 230                 235                 240 


Lys Pro Val Gly His Gly Arg Val Tyr Asp Val Asn Ser Leu Tyr Pro 
                245                 250                 255     


Ser Val Met Ser Asp Pro Gln Asn Lys Tyr Pro Ile Gly Thr Pro Val 
            260                 265                 270         


Phe Phe Glu Gly Lys Tyr Lys Asp Asp Pro Ile Tyr Pro Leu Tyr Ile 
        275                 280                 285             


Gln Phe Ile Thr Ala Gln Phe Glu Leu Lys Lys Gly Lys Ile Pro Thr 
    290                 295                 300                 


Ile Gln Ile Lys Asn Asp Lys Arg Phe Asn Pro Arg Glu Tyr Val Thr 
305                 310                 315                 320 


Ser Thr Gly Cys Leu Met Val Asn Leu Tyr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Glu Met Phe Tyr Glu Cys Tyr Asn Ile Lys Glu Ile Gln Tyr Ile Gly 
            340                 345                 350         


Gly Tyr Lys Phe Ile Gly Arg Ser Gly Ile Phe Ile Asp Tyr Val Asn 
        355                 360                 365             


His Phe Lys Glu Met Lys Met Gln Ala Thr Ile Glu Lys Asn Ala Gly 
    370                 375                 380                 


Lys Arg Ser Ile Ala Lys Leu Phe Leu Asn Ser Leu Tyr Gly Lys Phe 
385                 390                 395                 400 


Gly Ala Ser Asn Asp Lys Phe Val Lys Arg Pro Tyr Ile Asn Asp Lys 
                405                 410                 415     


Gly Ile Leu Ala Tyr Gln Thr Val Glu Thr Pro Arg Pro Ala Lys Thr 
            420                 425                 430         


Val Tyr Val Pro Val Ala Ala Phe Val Thr Ala Tyr Ala Arg Arg Phe 
        435                 440                 445             


Ile Gln Thr Leu Phe Ile Lys Asn Val Asp Arg Cys Cys Tyr Cys Asp 
    450                 455                 460                 


Thr Asp Ser Leu His Leu Ile Gly Asp Asp Pro Pro Glu Gly Val Lys 
465                 470                 475                 480 


Ile Ser Asp Thr Glu Phe Asn Cys Met Ala His Glu Ser Ser Phe Ser 
                485                 490                 495     


Arg Ala Lys Phe Leu Gly Ala Lys Leu Tyr Ile Glu Glu Asp Glu Gln 
            500                 505                 510         


Gly Asn Leu Asp Val Lys Ala Ala Gly Leu Gly Gln Asn Glu Val Val 
        515                 520                 525             


Lys Asn Gln Ile Thr Phe Asp Asn Phe Asn Thr Glu Gln Glu Tyr Phe 
    530                 535                 540                 


Gly Ile Leu Lys Ser Lys Thr Val Gln Gly Gly Val Glu Leu Ser Glu 
545                 550                 555                 560 


Ser Thr Phe Lys Ile Arg Glu Arg Gly Thr Arg Phe 
                565                 570         


<210>  12
<211>  568
<212>  PRT
<213>  Streptococcus phage CP-7

<400>  12

Met Thr Cys Tyr Tyr Ala Gly Asp Phe Glu Thr Thr Thr Asn Glu Glu 
1               5                   10                  15      


Glu Thr Glu Val Trp Leu Ser Cys Phe Ala Lys Val Ile Asp Tyr Asp 
            20                  25                  30          


Lys Leu Asp Thr Phe Lys Val Asn Thr Ser Leu Glu Asp Phe Leu Lys 
        35                  40                  45              


Ser Leu Tyr Leu Asp Leu Asp Lys Thr Tyr Thr Glu Thr Gly Glu Asp 
    50                  55                  60                  


Glu Phe Ile Ile Phe Phe His Asn Leu Lys Phe Asp Gly Ser Phe Leu 
65                  70                  75                  80  


Leu Ser Phe Phe Leu Asn Asn Asp Ile Glu Cys Thr Tyr Phe Ile Asn 
                85                  90                  95      


Asp Met Gly Val Trp Tyr Ser Ile Thr Leu Glu Phe Pro Asp Phe Thr 
            100                 105                 110         


Leu Thr Phe Arg Asp Ser Leu Lys Ile Leu Asn Phe Ser Ile Ala Thr 
        115                 120                 125             


Met Ala Gly Leu Phe Lys Met Pro Ile Ala Lys Gly Thr Thr Pro Leu 
    130                 135                 140                 


Leu Lys His Lys Pro Asp Glu Ile Lys Pro Glu Trp Ile Asp Tyr Ile 
145                 150                 155                 160 


His Val Asp Val Ala Ile Leu Ala Arg Gly Ile Phe Ala Met Tyr Tyr 
                165                 170                 175     


Glu Glu Asn Phe Ser Lys Tyr Thr Ser Ala Ser Glu Ala Leu Thr Glu 
            180                 185                 190         


Phe Lys Arg Ile Phe Arg Lys Ser Lys Arg Lys Phe Arg Asp Phe Phe 
        195                 200                 205             


Pro Ile Leu Asp Glu Lys Val Asp Asp Phe Cys Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Trp Thr Phe Ala Asn Pro Lys Thr Gln Gly Arg Thr Leu Lys 
225                 230                 235                 240 


Gln Leu Ile Asp Ile Tyr Asp Ile Asn Ser Met Tyr Pro Ala Thr Met 
                245                 250                 255     


Leu Gln Asn Ala Leu Pro Ile Gly Ile Pro Lys Arg Tyr Lys Gly Lys 
            260                 265                 270         


Pro Lys Glu Ile Lys Glu Asp His Tyr Tyr Ile Tyr His Ile Lys Ala 
        275                 280                 285             


Asp Phe Asp Leu Lys Arg Gly Tyr Leu Pro Thr Ile Gln Ile Lys Lys 
    290                 295                 300                 


Lys Leu Asp Ala Leu Arg Ile Gly Val Arg Thr Ser Asp Tyr Val Thr 
305                 310                 315                 320 


Thr Ser Lys Asn Glu Val Ile Asp Leu Tyr Leu Thr Asn Phe Asp Leu 
                325                 330                 335     


Asp Leu Phe Leu Lys His Tyr Asp Ala Thr Ile Met Tyr Val Glu Thr 
            340                 345                 350         


Leu Glu Phe Gln Thr Glu Ser Gly Leu Phe Asp Asp Tyr Ile Thr Thr 
        355                 360                 365             


Tyr Arg Tyr Lys Lys Glu Asn Ala Gln Ser Pro Ala Glu Lys Gln Lys 
    370                 375                 380                 


Ala Lys Ile Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Ala Lys Ile 
385                 390                 395                 400 


Ile Ser Val Lys Lys Leu Ala Tyr Leu Asp Asp Lys Gly Ile Leu Arg 
                405                 410                 415     


Phe Lys Asn Asp Asp Glu Glu Glu Val Gln Pro Val Tyr Ala Pro Val 
            420                 425                 430         


Ala Leu Phe Val Thr Ser Ile Ala Arg His Phe Ile Ile Ser Asn Ala 
        435                 440                 445             


Gln Glu Asn Tyr Asp Asn Phe Leu Tyr Ala Asp Thr Asp Ser Leu His 
    450                 455                 460                 


Leu Phe His Ser Asp Ser Leu Val Leu Asp Ile Asp Pro Ser Glu Phe 
465                 470                 475                 480 


Gly Lys Trp Ala His Glu Gly Arg Ala Val Lys Ala Lys Tyr Leu Arg 
                485                 490                 495     


Ser Lys Leu Tyr Ile Glu Glu Leu Ile Gln Glu Asp Gly Thr Thr His 
            500                 505                 510         


Leu Asp Val Lys Gly Ala Gly Met Thr Pro Glu Ile Lys Glu Lys Ile 
        515                 520                 525             


Thr Phe Glu Asn Phe Val Ile Gly Ala Thr Phe Glu Gly Lys Arg Ala 
    530                 535                 540                 


Ser Lys Gln Ile Lys Gly Gly Thr Leu Ile Tyr Glu Thr Thr Phe Lys 
545                 550                 555                 560 


Ile Arg Glu Thr Asp Tyr Leu Val 
                565             


<210>  13
<211>  616
<212>  PRT
<213>  Bacteroides sp.

<400>  13

Met Ser Lys Lys Ser Ala Lys Lys Pro Val Ile Ile Ala Ala Asp Phe 
1               5                   10                  15      


Glu Thr Thr Val Tyr Pro Gly Gln Thr Ser Thr Glu Val Trp Ser Ala 
            20                  25                  30          


Ala Trp Ile Glu Leu Phe Thr Glu Arg Pro His Val Arg Gly Asn Ile 
        35                  40                  45              


Glu Asp Phe Leu Asn Asp Ile Phe Asn Leu Asn Lys Asn Val Leu Cys 
    50                  55                  60                  


Tyr Phe His Asn Leu Arg Phe Asp Gly Ala Phe Ile Val Tyr Trp Leu 
65                  70                  75                  80  


Leu Lys Asn Gly Tyr Thr Trp Asn Asn Ala Arg Asn Lys Gly Met Asn 
                85                  90                  95      


Ala Lys Glu Phe Lys Ala Leu Ile Ser Asp Thr Asn Lys Trp Tyr Thr 
            100                 105                 110         


Val Thr Val Lys Pro Lys Phe Asp Thr Val Ile Glu Phe Arg Asp Ser 
        115                 120                 125             


Val Lys Leu Met Pro Met Thr Leu Asp Gln Ile Gly Ser Ala Phe Asn 
    130                 135                 140                 


Thr Lys His Arg Lys Leu Glu Met Glu Tyr Ile Gly Met Arg His Ala 
145                 150                 155                 160 


Asn Cys Glu Ile Thr Pro Glu Glu Tyr Ala Tyr Ile Ile Asn Asp Ile 
                165                 170                 175     


Tyr Val Leu Lys Glu Ala Leu Glu Val Met Ile Lys Ser Gly His Asp 
            180                 185                 190         


Lys Leu Thr Ile Gly Ser Cys Cys Met Asp Glu Phe Lys Asn Lys Phe 
        195                 200                 205             


Asp Ala Met Asp Phe Lys Ala Ala Phe Pro Asn Leu Lys Glu Ile Ala 
    210                 215                 220                 


Leu Ile Lys Tyr Glu Leu Gly Ser Asp Asn Val Asp Gln Tyr Ile Arg 
225                 230                 235                 240 


Lys Ala Tyr Lys Gly Gly Tyr Cys Tyr Tyr Lys Tyr Lys Gln Arg Lys 
                245                 250                 255     


His Ile Thr Gln Asn Gly Met Thr Phe Asp Val Asn Ser Leu Tyr Pro 
            260                 265                 270         


Ser Val Met His Ser Lys Ser Gly Asn Tyr Tyr Pro Thr Gly Lys Pro 
        275                 280                 285             


Ile Phe Phe Glu Lys Ala Ile Pro Tyr Lys Cys Leu Glu Ala Arg Val 
    290                 295                 300                 


Tyr Pro Phe Tyr Val Arg Leu Arg Cys Arg Phe Lys Leu Lys Asp Gly 
305                 310                 315                 320 


Phe Leu Pro Thr Val Gln Ile Lys Gly Asp Tyr Lys Tyr Asn Ser Thr 
                325                 330                 335     


Gln Trp Leu Glu Thr Ser Asp Ile Tyr Tyr Arg Gly Lys Tyr Tyr Arg 
            340                 345                 350         


Tyr Phe Thr Asn Lys Glu Gly Gln Lys Glu Glu Ala Arg Pro Glu Leu 
        355                 360                 365             


Thr Leu Phe Met Thr Asp Tyr Leu Leu Leu Leu Glu His Tyr Asp Val 
    370                 375                 380                 


Tyr Asp Leu Glu Ile Leu Asp Gly Cys Tyr Phe His Gly Ala Ile Gly 
385                 390                 395                 400 


Leu Phe Asp Thr Tyr Ile Asp His Tyr Met Lys Ile Lys Met Thr Thr 
                405                 410                 415     


Lys Asp Lys Gly Glu Arg Thr Glu Ala Lys Leu Phe Leu Asn Asn Leu 
            420                 425                 430         


Tyr Gly Arg Leu Ala Ile Asn Asp Asn Ser Ser Tyr Arg Glu Pro Phe 
        435                 440                 445             


Ile Asp Pro Glu Thr Asp Ser Ile Gly Phe Glu Leu His Pro Glu His 
    450                 455                 460                 


Glu Lys Asp Thr Leu Tyr Ile Ala Ala Gly Ala Ala Val Thr Ala Tyr 
465                 470                 475                 480 


Ala Arg Tyr Phe Thr Ile Thr His Ala Gln Ala Asn Tyr Gln Asn Phe 
                485                 490                 495     


Val Tyr Ser Asp Thr Asp Ser Ile His Met Leu Asp Asp Gly Gln Pro 
            500                 505                 510         


Val Lys Met Ile Lys Glu His Ala Thr Glu Leu Leu His Trp Lys Arg 
        515                 520                 525             


Glu Ser Asp Trp Ser Ser Ala Ile Phe Ile Arg Gln Lys Thr Tyr Ala 
    530                 535                 540                 


Glu Phe Val Gln Lys Glu Asp Gly Lys Lys Val Thr Gly His Trp Glu 
545                 550                 555                 560 


Ile Lys Cys Ala Gly Met Pro Glu Lys Ser Lys Lys Leu Phe Leu Ala 
                565                 570                 575     


Ser His Pro Ile Thr Asp Phe Lys Ile Gly Leu Lys Val Gly Gly Lys 
            580                 585                 590         


Leu Lys Pro Lys Tyr Ile Ser Gly Gly Met Val Leu Val Glu Asp Phe 
        595                 600                 605             


Tyr Thr Leu Arg Ala Lys Arg Cys 
    610                 615     


<210>  14
<211>  641
<212>  PRT
<213>  Chlamydia trachomatis

<400>  14

Met Lys Ala Arg Lys Phe Lys Ile Tyr Ala Ala Asp Phe Glu Thr Thr 
1               5                   10                  15      


Val Phe Lys Gly Gln Thr Phe Thr Glu Val Trp Ser Ala Cys Phe Cys 
            20                  25                  30          


Glu Leu Tyr Lys Lys Asp Ala Lys Ile Met His Ser Ile Gln Asp Phe 
        35                  40                  45              


Phe Asn Tyr Phe Phe Ser Leu Asn Glu Asn Ile Lys Met Tyr Phe His 
    50                  55                  60                  


Asn Leu Lys Phe Asp Gly Ser Phe Ile Leu Ser Tyr Leu Leu Lys Asp 
65                  70                  75                  80  


Leu Lys Tyr Glu Gln Ala Tyr Glu Lys Met Asn Ala Asp Gly Ser Leu 
                85                  90                  95      


Val Arg Trp Leu Glu Thr Lys Asp Met Lys Asn Asn Ser Ile Lys Tyr 
            100                 105                 110         


Ser Ile Ser Glu Met Gly Gln Trp Tyr Tyr Ile Ile Ile Lys Lys Asn 
        115                 120                 125             


Asn Lys Ile Ile Glu Ile Arg Asp Ser Leu Lys Leu Leu Pro Phe Ser 
    130                 135                 140                 


Leu Glu Ala Ile Gly Lys Ser Phe Asp Thr Glu His Lys Lys Leu Lys 
145                 150                 155                 160 


Met Lys Tyr Glu Gly Tyr Arg Tyr Ala Gly Cys Glu Ile Thr Pro Glu 
                165                 170                 175     


Glu Gln Ala Tyr Ile Lys Asn Asp Val Leu Val Leu Lys Glu Ala Leu 
            180                 185                 190         


Glu Ile Met Phe Asn Glu Lys His Glu Ser Leu Thr Ile Gly Ser Cys 
        195                 200                 205             


Cys Leu Asn Glu Tyr Lys Thr Ile Met Thr Lys Phe Leu Ile Glu Arg 
    210                 215                 220                 


Leu Tyr Pro Asn Ile Ala Glu Tyr Thr Val Asn Val Pro Leu Glu Phe 
225                 230                 235                 240 


Lys Asn Ala Asp Glu Tyr Val Arg Lys Ser Tyr Lys Gly Gly Trp Cys 
                245                 250                 255     


Tyr Leu Lys Lys Gly Cys Glu Asn Lys Ile Tyr Asn Asn Gly Thr Thr 
            260                 265                 270         


Ala Asp Val Asn Ser Leu Tyr Ser Ser Val Met His Ser Glu Ser Gly 
        275                 280                 285             


Asn Tyr Tyr Pro Val Gly Leu Pro Thr Phe Trp Ser Gly Asn Tyr Ile 
    290                 295                 300                 


Pro Glu Ile Ala Lys Glu Lys Tyr Tyr Phe Ile Arg Ile Lys Thr Arg 
305                 310                 315                 320 


Phe Tyr Leu Lys Lys Arg Phe Leu Pro Cys Ile Gln Val Lys Asn Thr 
                325                 330                 335     


Tyr Arg Tyr Lys Ser Thr Glu Trp Leu Glu Thr Ser Asp Phe Tyr Asp 
            340                 345                 350         


Lys Lys Thr Asn Lys Tyr Tyr Lys Lys Tyr Leu Asp Ile Asn Gly Asn 
        355                 360                 365             


Glu Gln Asn Thr Gln Val Ile Leu Thr Leu Thr Met Thr Asp Phe Glu 
    370                 375                 380                 


Leu Ile Lys Glu His Tyr Asn Leu Val Asp Phe Glu Ile Leu Asp Gly 
385                 390                 395                 400 


Cys Tyr Phe Asp Lys Glu Ile Gly Leu Phe Asp Glu Tyr Ile Asn Lys 
                405                 410                 415     


Tyr Lys Lys Ile Lys Leu Asn Ser Lys Gly Ala Lys Lys Thr Leu Ala 
            420                 425                 430         


Lys Leu Tyr Leu Asn Asn Leu Tyr Gly Lys Thr Ala Thr Asn Thr Asp 
        435                 440                 445             


Ser Ser Phe Lys Val Ala Tyr Ile Lys Asp Asp Leu Ser Leu Gly Phe 
    450                 455                 460                 


Tyr Gly Val Tyr Ala Cys Asp Lys Lys Pro Phe Tyr Ile Pro Val Gly 
465                 470                 475                 480 


Ser Ala Ile Thr Ser Tyr Ala Arg Asn Phe Thr Ile Arg Ala Ala Gln 
                485                 490                 495     


Lys Asn Tyr Lys Asn Phe Ile Tyr Ala Asp Thr Asp Ser Ile His Cys 
            500                 505                 510         


Lys Cys Asn Pro Ala Glu Ile Lys Gly Ile Thr Ile Asp Asp Lys Lys 
        515                 520                 525             


Phe Leu Cys Trp Lys Leu Glu Ser Cys Trp Asp Lys Gly Leu Phe Val 
    530                 535                 540                 


Arg Gln Lys Thr Tyr Ile Glu His Ile Thr Ala Glu Asn Leu Lys Pro 
545                 550                 555                 560 


Ile Asp Lys Pro Phe Tyr Asn Val Lys Cys Ala Gly Met Pro Glu Gln 
                565                 570                 575     


Cys Lys Thr Leu Phe Leu Lys Ser Ile Gly Glu Asp Val Asp Ile Ser 
            580                 585                 590         


Asp Leu Asn Ile Asn Asp Asp Ala Lys Glu Phe Leu Lys Lys Lys Arg 
        595                 600                 605             


Thr Ile Lys Asp Phe Lys Ala Gly Leu Ser Val Pro Leu Lys Leu Arg 
    610                 615                 620                 


Pro Val Gln Ile Asn Gly Gly Val Leu Leu Thr Glu Thr Phe Tyr Thr 
625                 630                 635                 640 


Met 
    


<210>  15
<211>  574
<212>  PRT
<213>  Globodera pallida

<400>  15

Met Pro Leu Pro Arg Lys Lys Ala Ser Ser Asn Gly Leu Ser Lys Arg 
1               5                   10                  15      


Ile Tyr Leu Ala Asp Phe Glu Thr Thr Thr Gln Ala Glu Asp Cys Arg 
            20                  25                  30          


Val Trp Ser Trp Gly Leu Cys Ser Val Glu Asn Thr Glu Asn Val Glu 
        35                  40                  45              


Phe Gly Gly Asp Leu Asp Ser Phe Ile Glu Arg Ile Ser Glu Glu Asn 
    50                  55                  60                  


Ser Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu 
65                  70                  75                  80  


Asp Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro 
                85                  90                  95      


Gln Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr 
            100                 105                 110         


Ser Ile Lys Val Arg Trp Glu Asn Gly Met Phe Thr Glu Phe Arg Asp 
        115                 120                 125             


Ser Leu Lys Lys Leu Pro Met Ser Val Lys Gln Val Ala Lys Thr Phe 
    130                 135                 140                 


Lys Leu Asp Gln Ala Lys Gly Glu Ile Asp Tyr His Tyr Leu Arg Pro 
145                 150                 155                 160 


Val Gly Trp Val Met Thr Pro Glu Glu Arg Glu Tyr Val Lys Asn Asp 
                165                 170                 175     


Val Gln Ile Val Ala Arg Ala Leu Lys Val Gln Leu Gln Glu Gly Met 
            180                 185                 190         


Thr Arg Leu Thr Val Gly Ala Asp Ser Leu Ala Gln Tyr Lys Ser Met 
        195                 200                 205             


Met Gly Lys Asp Phe Glu Arg His Phe Pro Val Leu Thr Arg Thr Ile 
    210                 215                 220                 


Asp Ala Glu Ile Arg Arg Ala Tyr Arg Gly Gly Trp Ala Tyr Ala Asp 
225                 230                 235                 240 


Glu Arg His Arg Gly Lys Val Val Gly Ala Gly Gln Thr Phe Asp Val 
                245                 250                 255     


Asn Ser Leu Tyr Pro Ser Val Met Tyr Ser Lys Val Leu Pro Tyr Gly 
            260                 265                 270         


Glu Pro Val Phe Tyr Pro Asn Gly Leu Pro Glu Val Thr Glu Asp His 
        275                 280                 285             


Pro Leu Phe Ile Thr Cys Ile Thr Phe Thr Ala Lys Ile Arg Asp Gly 
    290                 295                 300                 


His Leu Pro Cys Ile Gln Ile Lys Asn Ser Ser Leu Phe Thr Pro Thr 
305                 310                 315                 320 


Glu Tyr Val Lys Glu Val Leu Asp Pro Ile Thr Met Tyr Cys Thr Asn 
                325                 330                 335     


Val Asp Leu Glu Leu Trp Gln Glu His Tyr Asp Met Asp Ile Leu Ala 
            340                 345                 350         


Tyr Asn Gly Ala Trp Leu Phe Arg Gly Ile Arg Gly Phe Phe Asn Asp 
        355                 360                 365             


Tyr Ile Asp His Trp Met Arg Ile Lys Glu Glu Ser Glu Gly Gly Arg 
    370                 375                 380                 


Lys Leu Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Thr Asn Pro Asp Val Thr Pro Lys Ile Pro Ile Phe Asp Glu Glu Lys 
                405                 410                 415     


Asp Ile Val Arg Leu Ile Glu Gly Pro Pro Asp Glu Arg Asn Pro Val 
            420                 425                 430         


Tyr Thr Ala Met Gly Val Phe Ile Thr Ser Tyr Ala Arg Asp Leu Thr 
        435                 440                 445             


Ile Arg Thr Ala Gln Asp His Tyr Asp Arg Phe Leu Tyr Ala Asp Thr 
    450                 455                 460                 


Asp Ser Leu His Leu Leu Thr Ser Asp Gly Thr Asn Asn Gly Arg Lys 
465                 470                 475                 480 


Ser Lys Ala Leu Glu Val His Pro Ser Lys Leu Gly Tyr Trp Lys His 
                485                 490                 495     


Glu Tyr Asp Phe Asp Ala Gly Leu Phe Val Arg Ala Lys Ala Tyr Thr 
            500                 505                 510         


Glu Leu Met Thr Gly Glu Phe His Val Lys Ser Lys Cys Glu Cys Asp 
        515                 520                 525             


Thr Pro Asn Asp Leu His Tyr Gln Thr His Ile Ala Gly Met Pro Glu 
    530                 535                 540                 


Ala Ile Ala Gln His Ile Thr Phe Glu Ser Tyr Arg Asp Gly Ala Thr 
545                 550                 555                 560 


Phe Glu Gly Lys Leu Ala Pro Gln Arg Val Pro Gly Gly Ile 
                565                 570                 


<210>  16
<211>  584
<212>  PRT
<213>  Globodera sp.

<400>  16

Met Pro Leu Pro Arg Lys Lys Ala Ser Ser Asn Gly Leu Ser Lys Arg 
1               5                   10                  15      


Ile Tyr Leu Ala Asp Phe Glu Thr Thr Thr Gln Ala Glu Asp Cys Arg 
            20                  25                  30          


Val Trp Ser Trp Gly Leu Cys Ser Val Glu Asn Thr Glu Asn Val Glu 
        35                  40                  45              


Phe Gly Gly Asp Leu Asp Ser Phe Ile Glu Arg Ile Ser Glu Glu Asn 
    50                  55                  60                  


Ser Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu 
65                  70                  75                  80  


Asp Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro 
                85                  90                  95      


Gln Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr 
            100                 105                 110         


Ser Ile Lys Val Arg Trp Glu Asn Gly Met Phe Thr Glu Phe Arg Asp 
        115                 120                 125             


Ser Leu Lys Lys Leu Pro Met Ser Val Lys Gln Val Ala Lys Thr Phe 
    130                 135                 140                 


Lys Leu Asp Gln Ala Lys Gly Glu Ile Asp Tyr His Tyr Leu Arg Pro 
145                 150                 155                 160 


Val Gly Trp Val Met Thr Pro Glu Glu Arg Glu Tyr Val Lys Asn Asp 
                165                 170                 175     


Val Gln Ile Val Ala Arg Ala Leu Lys Val Gln Leu Gln Glu Gly Met 
            180                 185                 190         


Thr Arg Leu Thr Val Gly Ala Asp Ser Leu Ala Gln Tyr Lys Ser Met 
        195                 200                 205             


Met Gly Lys Asp Phe Glu Arg His Phe Pro Val Leu Thr Arg Thr Ile 
    210                 215                 220                 


Asp Ala Glu Ile Arg Arg Ala Tyr Arg Gly Gly Trp Ala Tyr Ala Asp 
225                 230                 235                 240 


Glu Arg His Arg Gly Lys Val Val Gly Ala Gly Gln Thr Phe Asp Val 
                245                 250                 255     


Asn Ser Leu Tyr Pro Ser Val Met Tyr Ser Lys Val Leu Pro Tyr Gly 
            260                 265                 270         


Glu Pro Val Phe Tyr Pro Asn Gly Leu Pro Glu Val Thr Glu Asp His 
        275                 280                 285             


Pro Leu Phe Ile Thr Cys Ile Thr Phe Thr Ala Lys Ile Arg Asp Gly 
    290                 295                 300                 


His Leu Pro Cys Ile Gln Ile Lys Asn Ser Ser Leu Phe Thr Pro Thr 
305                 310                 315                 320 


Glu Tyr Val Lys Glu Val Leu Asp Pro Ile Thr Met Tyr Cys Thr Asn 
                325                 330                 335     


Val Asp Leu Glu Leu Trp Gln Glu His Tyr Asp Met Asp Ile Leu Ala 
            340                 345                 350         


Tyr Asn Gly Ala Trp Leu Phe Arg Gly Ile Arg Gly Phe Phe Asn Asp 
        355                 360                 365             


Tyr Ile Asp His Trp Met Arg Ile Lys Glu Glu Ser Glu Gly Gly Arg 
    370                 375                 380                 


Lys Leu Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Thr Asn Pro Asp Val Thr Pro Lys Ile Pro Ile Phe Asp Glu Glu Lys 
                405                 410                 415     


Asp Ile Val Arg Leu Ile Glu Gly Pro Pro Asp Glu Arg Asn Pro Val 
            420                 425                 430         


Tyr Thr Ala Met Gly Val Phe Ile Thr Ser Tyr Ala Arg Asp Leu Thr 
        435                 440                 445             


Ile Arg Thr Ala Gln Asp His Tyr Asp Arg Phe Leu Tyr Ala Asp Thr 
    450                 455                 460                 


Asp Ser Leu His Leu Leu Thr Ser Asp Gly Thr Asn Asn Gly Arg Lys 
465                 470                 475                 480 


Ser Lys Ala Leu Glu Val His Pro Ser Lys Leu Gly Tyr Trp Lys His 
                485                 490                 495     


Glu Tyr Asp Phe Asp Ala Gly Leu Phe Val Arg Ala Lys Ala Tyr Thr 
            500                 505                 510         


Glu Leu Met Thr Gly Glu Phe His Val Lys Ser Lys Cys Glu Cys Asp 
        515                 520                 525             


Thr Pro Asn Asp Leu His Tyr Gln Thr His Ile Ala Gly Met Pro Glu 
    530                 535                 540                 


Ala Ile Ala Gln His Ile Thr Phe Glu Ser Tyr Arg Asp Gly Ala Thr 
545                 550                 555                 560 


Phe Glu Gly Lys Leu Ala Pro Gln Arg Val Pro Gly Gly Ile Val Leu 
                565                 570                 575     


Val Asp Asp Thr Phe Thr Ile Lys 
            580                 


<210>  17
<211>  548
<212>  PRT
<213>  Lynx pardinus


<220>
<221>  misc_feature
<222>  (339)..(374)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Met Pro Ser Tyr Thr Ala Asp Phe Glu Thr Thr Thr Val Ala Asp Asp 
1               5                   10                  15      


Cys Arg Val Trp Ala Trp Ala Thr Ser Arg Ile Gly Asn Pro Asp Asp 
            20                  25                  30          


Val Gln Leu Gly Asn Ser Ile Asp Thr Phe Leu Glu Trp Cys Arg Val 
        35                  40                  45              


His Ser Gly Ser Arg Val Tyr Phe His Asn Leu Lys Phe Asp Gly Lys 
    50                  55                  60                  


Phe Ile Leu His Lys Ile Leu Thr Asp Gly Trp Lys Trp Ile Pro Asp 
65                  70                  75                  80  


Lys Asn Asp Cys Ala Asn Arg Thr Phe Thr Thr Leu Ile Ser Asp Met 
                85                  90                  95      


Ser Gln Phe Tyr Ser Ile Lys Leu Trp Phe Asp Glu Ser Lys Ser Ile 
            100                 105                 110         


Glu Phe Leu Asp Ser Leu Lys Val Ile Pro Leu Pro Ile Ala Ala Ile 
        115                 120                 125             


Pro Lys Ala Phe Gly Leu Glu Ile Glu Lys Leu Asp Leu Asp Tyr Gln 
    130                 135                 140                 


Ala Ser Arg Glu Val Gly His Glu Leu Thr Glu Asp Glu Lys Glu Tyr 
145                 150                 155                 160 


Ile Ala His Asp Val Lys Ile Ala Ala Met Ala Met Asp Thr Met Phe 
                165                 170                 175     


Ser Gln Gly Met Lys Lys Ile Thr Ala Gly Ser Asn Ala Phe Ala Asp 
            180                 185                 190         


Tyr Lys Lys Thr Ile Gly Gly Lys Lys Arg Phe Arg Asp Trp Phe Pro 
        195                 200                 205             


Glu Pro Glu Tyr Asp Glu Asp Leu Arg Lys Gly Gly Cys Tyr Lys Gly 
    210                 215                 220                 


Gly Phe Thr Ala Val Asn Pro Lys Ile Ala Gly Lys Lys Leu Gly Lys 
225                 230                 235                 240 


Gly Val Ser Phe Asp Val Asn Ser Leu Tyr Pro Ser Val Met Ala Ser 
                245                 250                 255     


Ser His Gly Glu Val Leu Pro Tyr Gly Glu Pro Ile Pro Tyr Asp Gly 
            260                 265                 270         


Gly Tyr Glu Gln Asp Glu Asp His Pro Leu Tyr Ile Gln Phe Ile Glu 
        275                 280                 285             


Ala Asp Phe Ala Val Lys Glu Asn Arg Ile Pro Cys Leu Gln Leu Lys 
    290                 295                 300                 


Gly Asn Val Met Phe Gly Glu Thr Glu Tyr Ile Arg Asp Ser Lys Gly 
305                 310                 315                 320 


Met Gln Thr Leu Cys Leu Thr Ser Val Asp Met Glu Met Leu Phe Glu 
                325                 330                 335     


His Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Arg Thr Ile Ala Lys Leu Gln Leu Asn Ser 
    370                 375                 380                 


Leu Phe Ala Ala Asn Pro Val Lys Gln Ser Arg Met Pro Tyr Leu Asp 
385                 390                 395                 400 


Glu Gly Ile Val Lys Tyr Ala Leu Leu Glu Pro Glu His Ala Glu Ala 
                405                 410                 415     


Gln Tyr Leu Pro Ala Gly Ala Phe Ile Thr Ser Tyr Ala Arg Gln Phe 
            420                 425                 430         


Thr Ile Arg Ala Ala Gln Ala Asn Tyr Glu Arg Trp Leu Tyr Cys Asp 
        435                 440                 445             


Thr Asp Ser Val Tyr Leu Arg Gly Thr Glu Pro Pro Val Asp Met Arg 
    450                 455                 460                 


Val Asp Ala Tyr Glu Leu Gly Ala Trp Lys Lys Glu His Glu Phe Asp 
465                 470                 475                 480 


Cys Phe Lys Ala Ile Arg Ala Lys Thr Tyr Cys Phe Glu Glu Asp Gly 
                485                 490                 495     


Glu Leu Thr Val His Cys Ala Gly Met Pro Ala Arg Cys His Glu His 
            500                 505                 510         


Val Thr Met Asp Asn Phe Glu Val Gly Ala Ser Phe Pro Gly Lys Leu 
        515                 520                 525             


Lys Pro Lys Asp Val Asn Gly Gly Thr Ile Leu Val Glu Asp Val Phe 
    530                 535                 540                 


Thr Ile Arg Pro 
545             


<210>  18
<211>  611
<212>  PRT
<213>  Enterococcus faecium (SK)

<400>  18

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Asp Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Lys 
65                  70                  75                  80  


Glu Thr Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Glu Val Asn Tyr Thr Thr Thr 
            100                 105                 110         


Lys Ser Gly Lys Thr Lys Lys Glu Lys Val Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Gln Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Val Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Lys Asp Trp 
        195                 200                 205             


Leu Lys Ala Thr His Gly Lys Ser Thr Phe Lys Gln Trp Phe Pro Ile 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Asp Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Pro 
        275                 280                 285             


Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Val Gly 
465                 470                 475                 480 


Thr Asp Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Gly His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys Gly His His 
                565                 570                 575     


His His His His His His His His Gly Gly Gly Ser Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys Ile Glu 
        595                 600                 605             


Trp His Glu 
    610     


<210>  19
<211>  646
<212>  PRT
<213>  Bacillus phage Harambe

<400>  19

Met Gly Asn Lys Lys Arg Lys Ile Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Leu Met Glu Ile 
            20                  25                  30          


Asp Gly Lys Phe Glu Asn Tyr Lys Glu Gly Asn Asn Ile Asp Glu Phe 
        35                  40                  45              


Met Glu Trp Thr Glu Gln Glu Gln Gly Asp Leu Tyr Phe His Asn Leu 
    50                  55                  60                  


Arg Phe Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys Gly Tyr 
65                  70                  75                  80  


Arg Phe Asn Asn Thr Arg Lys Ala Gly Thr Phe Asn Ala Val Ile Ser 
                85                  90                  95      


Ser Met Gly Gln Trp Tyr Lys Ile Asp Ile Tyr Tyr Gly Arg Glu Gly 
            100                 105                 110         


Lys Lys Val Phe Lys Thr Ser Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Ile Glu Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr Asp Ala Pro Arg Pro Val Gly His Gln Ile Thr 
145                 150                 155                 160 


Pro Asp Glu Ser Lys Tyr Ile Lys Asn Asp Val Glu Ile Ile Ala Arg 
                165                 170                 175     


Ala Leu His Ser Gln Leu Asn Thr Ala Lys Leu Thr Lys Met Thr Ile 
            180                 185                 190         


Gly Ser Asp Ala Leu Asp Gly Phe Lys His Ser Leu His Lys Ser Pro 
        195                 200                 205             


Lys Val Ser Lys Arg Met Tyr Asp His His Phe Pro Val Ile Ser Asn 
    210                 215                 220                 


Ala Ile His Glu Glu Phe Lys Lys Ala Tyr Arg Gly Gly Phe Thr Trp 
225                 230                 235                 240 


Ala Asn Pro Lys Tyr Ala Gly Lys Val Ile Gly Asn Gly Leu Val Phe 
                245                 250                 255     


Asp Val Asn Ser Leu Tyr Pro Ser Val Met Tyr Asp Lys Pro Leu Pro 
            260                 265                 270         


Tyr Gly Leu Pro Val Pro Phe Ser Gly Glu Tyr Glu Tyr Asp Glu Thr 
        275                 280                 285             


His Pro Leu Phe Ile Gln His Ile Lys Cys Gly Phe Glu Leu Lys Asp 
    290                 295                 300                 


Gly His Ile Pro Thr Ile Gln Ile Lys Lys Asn Phe Arg Phe Ala Asp 
305                 310                 315                 320 


Asn Glu Tyr Leu His Ser Ser Glu Gly Asn Ile Leu Asp Leu His Val 
                325                 330                 335     


Thr Asn Val Asp Leu Ala Leu Ile Lys Glu His Tyr Thr Leu Tyr Glu 
            340                 345                 350         


Glu Glu Tyr Leu Gln Gly Tyr Lys Phe Lys Gln Val Thr Gly Leu Phe 
        355                 360                 365             


Lys Asn Tyr Ile Asp Tyr Trp Ser Asp Lys Lys Ile Asn Ala Glu Asp 
    370                 375                 380                 


Pro Ala Ile Arg Gln Met Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly 
385                 390                 395                 400 


Lys Phe Gly Thr Ser Ile Asp Val Thr Gly Lys Glu Val Phe Leu Lys 
                405                 410                 415     


Glu Asp Gly Ser Thr Gly Phe Arg Lys Gly Gln Lys Glu Glu Arg Asp 
            420                 425                 430         


Pro Val Tyr Met Pro Met Gly Ala Phe Ile Thr Ala Tyr Ala Arg Asp 
        435                 440                 445             


Val Thr Ile Arg Thr Ala Gln Lys Cys Tyr Asp Arg Ile Leu Tyr Cys 
    450                 455                 460                 


Asp Thr Asp Ser Ile His Leu Val Gly Thr Glu Ile Pro Glu Ala Ile 
465                 470                 475                 480 


Lys Asp Arg Ile His Asp Lys Lys Leu Gly Tyr Trp Ala His Glu Ser 
                485                 490                 495     


Thr Phe Trp Arg Ala Lys Phe Ile Arg Gln Lys Thr Tyr Ile Glu Asp 
            500                 505                 510         


Leu Cys Met Arg Phe Glu Gly Glu Lys Val Asn Gly Glu Trp Lys Phe 
        515                 520                 525             


Lys Met Val Glu Glu Lys Asp Ile Thr Lys Ala Thr Ala Arg Glu Leu 
    530                 535                 540                 


Ser Val Lys Cys Ala Gly Met Pro Ala Gln Val Lys Gln Tyr Val Thr 
545                 550                 555                 560 


Phe Asp Asn Phe Gly Val Asp Phe Lys His Asp Pro Asn Asp Tyr Thr 
                565                 570                 575     


Asp Glu Glu Ile Lys Arg Lys Asn Ile Lys Phe Lys Leu Lys Pro Thr 
            580                 585                 590         


His Arg Lys Gly Gly Gln Val Leu Val Pro Thr Pro Phe Thr Ile Lys 
        595                 600                 605             


Gly His His His His His His His His His His Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln 
625                 630                 635                 640 


Lys Ile Glu Trp His Glu 
                645     


<210>  20
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 
        195                 200                 205             


Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 
        355                 360                 365             


Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 
                405                 410                 415     


Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 
    530                 535                 540                 


Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  21
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 
        195                 200                 205             


Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 
        355                 360                 365             


Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 
                405                 410                 415     


Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 
    530                 535                 540                 


Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  22
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 
        195                 200                 205             


Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 
        355                 360                 365             


Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 
                405                 410                 415     


Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Tyr Leu Lys Glu 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 
    530                 535                 540                 


Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  23
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 
        195                 200                 205             


Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 
        355                 360                 365             


Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 
                405                 410                 415     


Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Tyr Leu Lys Glu 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 
    530                 535                 540                 


Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  24
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  25
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  26
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  27
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 
        195                 200                 205             


Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ser Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 
        355                 360                 365             


Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 
                405                 410                 415     


Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Lys Gly Tyr Leu Lys Gln 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 
    530                 535                 540                 


Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  28
<211>  589
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 
            20                  25                  30          


Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 
        35                  40                  45              


Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 
65                  70                  75                  80  


Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 
                85                  90                  95      


Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 
            100                 105                 110         


Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 
145                 150                 155                 160 


Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 
            180                 185                 190         


Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr Glu 
        195                 200                 205             


Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Gly Lys 
225                 230                 235                 240 


Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe 
            260                 265                 270         


Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys 
        275                 280                 285             


Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln 
    290                 295                 300                 


Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser 
305                 310                 315                 320 


Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu 
                325                 330                 335     


Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly 
            340                 345                 350         


Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp Lys 
        355                 360                 365             


Trp Met Leu Val Lys Asn Met Ser Tyr Gly Ala Lys Lys Ala Ile Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly Phe 
                405                 410                 415     


Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val Gly 
            420                 425                 430         


Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala Gln 
        435                 440                 445             


Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His Leu 
    450                 455                 460                 


Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp Asp 
465                 470                 475                 480 


Val Leu Gly Tyr Trp Glu Lys Glu Gly Gln Phe Lys Gln Gly Lys Phe 
                485                 490                 495     


Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val Arg 
            500                 505                 510         


Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Tyr Lys Thr 
        515                 520                 525             


Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys Cys 
    530                 535                 540                 


Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn Phe 
545                 550                 555                 560 


Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val Tyr 
                565                 570                 575     


Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys 
            580                 585                 


<210>  29
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  30
<211>  592
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Met Ala Thr Lys Lys Arg Lys Ala Tyr Ser Cys Asp Phe Glu Ala Thr 
1               5                   10                  15      


Thr Ser Thr Tyr Ser Glu Thr Glu Thr Arg Val Trp Ala Tyr Gly Trp 
            20                  25                  30          


Met Glu Ile Gly Asn Thr Ser His Phe Asn Ile Gly Asp Asn Leu Asp 
        35                  40                  45              


Glu Phe Met Leu Trp Thr Ser Lys Glu Cys Ala Asp Leu Tyr Phe His 
    50                  55                  60                  


Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys 
65                  70                  75                  80  


Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys Thr Phe Asp Thr Val 
                85                  90                  95      


Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala Ile His His Glu Gly 
            100                 105                 110         


Lys Gly Thr Thr Gln Ile Phe Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Val Leu Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile Asn Leu His Arg Asp Glu Asn His Val Ile Thr Ser Glu 
145                 150                 155                 160 


Glu Phe Thr Tyr Ile Lys His Asp Ile Glu Ile Val Ala Arg Ala Leu 
                165                 170                 175     


Asp Ile Gln Ile Asn Gln Gln Gly Leu Val Lys Met Thr Asn Gly Ala 
            180                 185                 190         


Asp Ser Met Asp His Phe Ile Lys Ser Leu Asp Lys Lys Lys Lys Val 
        195                 200                 205             


Ala Glu Arg Ile Tyr Asn Gln Tyr Phe Pro Lys Met Ser Ile Ala Met 
    210                 215                 220                 


Asp Ser Ile Phe Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Val Asn 
225                 230                 235                 240 


Pro Lys Phe Lys Gly Gln Glu Val Gly Glu Gly Met Val Phe Asp Ala 
                245                 250                 255     


Asn Ser Ala Tyr Pro Ser Val Met Tyr Tyr Lys Pro Leu Pro Trp Gly 
            260                 265                 270         


Lys Pro Val Pro Phe Val Gly Lys Tyr Glu Glu Asp Pro Asp Phe Pro 
        275                 280                 285             


Leu Tyr Ile Cys His Ile Lys Thr Gly Phe Val Leu Lys Glu Gly His 
    290                 295                 300                 


Ile Pro Thr Ile Gln Ile Lys Lys Asn Pro Ile Phe Gln Glu Asn Glu 
305                 310                 315                 320 


Tyr Leu Glu Thr Ser Gly Gly Ala Pro Val Asp Leu His Val Thr Asn 
                325                 330                 335     


Val Asp Leu Glu Leu Ile Lys Glu His Tyr Glu Leu Tyr Asp Thr Glu 
            340                 345                 350         


Tyr Val Gly Gly Trp Lys Phe Arg Gln Gln Thr Gly Ile Phe Asn Asn 
        355                 360                 365             


Phe Ile Asp Tyr Trp Met Lys Ile Lys Thr Asp Pro Lys Ser Thr Pro 
    370                 375                 380                 


Ala Ile Val Thr Leu Ala Lys Leu Gln Leu Asn Ser Leu Tyr Gly Lys 
385                 390                 395                 400 


Phe Ala Ser His Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp 
                405                 410                 415     


Asp Gly Ser Thr Ala Phe Lys Lys Gly Leu Pro Lys Ser Lys Asp Pro 
            420                 425                 430         


Val Tyr Thr Pro Ala Gly Ala Phe Ile Thr Ala Trp Ala Arg His Met 
        435                 440                 445             


Thr Ile Thr Thr Ala Gln Lys Val Tyr Asp Arg Ile Leu Tyr Cys Asp 
    450                 455                 460                 


Thr Asp Ser Ile His Ile Leu Gly Ile Asp Ile Pro Glu Ala Ile Lys 
465                 470                 475                 480 


Asn Asp Ile His Gln Lys Glu Leu Gly Lys Trp Glu Phe Glu Cys Met 
                485                 490                 495     


Phe Lys Arg Ala Lys Phe Val Arg Gln Lys Thr Tyr Val Glu Asp Met 
            500                 505                 510         


Tyr Ala Lys Phe Met Lys Tyr Trp Glu Asp Gly Glu Leu Asn Tyr Tyr 
        515                 520                 525             


Leu Lys Glu Cys Val Lys Glu Glu Ala Thr Ala Arg Leu Leu Asn Val 
    530                 535                 540                 


Lys Cys Ala Gly Met Pro Gln Ala Val Lys Lys Phe Val Thr Phe Arg 
545                 550                 555                 560 


Thr Phe Ala Val Gly Phe Thr Ser Asp Thr Gly Lys Leu Lys Pro Lys 
                565                 570                 575     


His Val Lys Gly Gly Gln Ile Leu Val Asp Val Pro Phe Thr Ile Lys 
            580                 585                 590         


<210>  31
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  32
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  33
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  34
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  35
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  36
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  37
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  38
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Thr 
    370                 375                 380                 


Glu Val Lys Thr Thr Thr Tyr Gly Ala Arg Lys Gln Leu Ala Lys Leu 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  39
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Gln Asn Ala Lys Leu 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
                565                 570             


<210>  40
<211>  591
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 
        195                 200                 205             


Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 
        275                 280                 285             


Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
465                 470                 475                 480 


Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Tyr Met Lys Arg Val Lys Gly Tyr 
        515                 520                 525             


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Glu Leu Asn Val 
    530                 535                 540                 


Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp 
545                 550                 555                 560 


Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg 
                565                 570                 575     


Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 
            580                 585                 590     


<210>  41
<211>  611
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Asp Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Lys 
65                  70                  75                  80  


Glu Thr Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Glu Val Asn Tyr Thr Thr Thr 
            100                 105                 110         


Lys Ser Gly Lys Thr Lys Lys Glu Lys Val Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Gln Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Val Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Lys Asp Trp 
        195                 200                 205             


Leu Lys Ala Thr His Gly Lys Ser Thr Phe Lys Gln Trp Phe Pro Ile 
    210                 215                 220                 


Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 
225                 230                 235                 240 


Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Asp Gly 
                245                 250                 255     


Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 
            260                 265                 270         


Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Pro 
        275                 280                 285             


Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 
    290                 295                 300                 


Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 
305                 310                 315                 320 


Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys Leu Gly Val 
                325                 330                 335     


Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Phe 
            340                 345                 350         


Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 
        355                 360                 365             


Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 
    370                 375                 380                 


Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 
385                 390                 395                 400 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 
                405                 410                 415     


Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 
            420                 425                 430         


Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 
        435                 440                 445             


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 
    450                 455                 460                 


Phe Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Val Gly 
465                 470                 475                 480 


Thr Asp Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu 
                485                 490                 495     


Gly Tyr Trp Gly His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 
            500                 505                 510         


Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 
        515                 520                 525             


Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 
    530                 535                 540                 


Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys Gly His His 
                565                 570                 575     


His His His His His His His His Gly Gly Gly Ser Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys Ile Glu 
        595                 600                 605             


Trp His Glu 
    610     


<210>  42
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly 
                565                 570                 575     


His His His His His His His His His His Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 
        595                 600                 605             


Ile Glu Trp His Glu 
    610             


<210>  43
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  44
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Lys Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  45
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  46
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Cys His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  47
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Arg Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  48
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Arg Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  49
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Arg Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  50
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Asp Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  51
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  52
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Asp Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  53
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Phe Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  54
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  55
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Cys His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  56
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ser His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  57
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Thr His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  58
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Asn His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  59
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Gln His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  60
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  61
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  62
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Asn His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  63
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Gln His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  64
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Phe 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  65
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Lys Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  66
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ser 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  67
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Asp Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  68
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Trp Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  69
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Trp Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  70
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Phe Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  71
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Ala Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  72
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Arg Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  73
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Asp 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Lys 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  74
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Glu 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Lys 
465                 470                 475                 480 


Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  75
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly 
                565                 570                 575     


His His His His His His His His His His Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 
        595                 600                 605             


Ile Glu Trp His Glu 
    610             


<210>  76
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys Gly 
                565                 570                 575     


His His His His His His His His His His Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 
        595                 600                 605             


Ile Glu Trp His Glu 
    610             


<210>  77
<211>  613
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly 
                565                 570                 575     


His His His His His His His His His His Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 
        595                 600                 605             


Ile Glu Trp His Glu 
    610             


<210>  78
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  78

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  79
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  79

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  80
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  80

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  81
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  81

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  82
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  82

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  83
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  83

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  84
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  84

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  85
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  85

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  86
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  86

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  87
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  87

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  88
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  88

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  89
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  89

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Asn Val Asn Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  90
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  90

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  91
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  91

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Asn Val Asn Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  92
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  92

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  93
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  93

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  94
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 
            500                 505                 510         


Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  95
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  95

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 
            500                 505                 510         


Leu Val Asn Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  96
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 
            500                 505                 510         


Leu Val Asn Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  97
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  98
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  99
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  100
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  101
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 
        275                 280                 285             


Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu 
305                 310                 315                 320 


Val Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  102
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 
        275                 280                 285             


Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu 
305                 310                 315                 320 


Val Glu Leu Trp Ile Ser Gln Val Asp Ile Asp Leu Met Lys Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Ile Lys Phe Arg Ala 
            340                 345                 350         


Thr Thr Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  103
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Arg Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Leu Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Asn Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Leu Val Asn Trp Leu Glu Gln His Gly Phe Arg Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  104
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Arg Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Leu Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Asn Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Leu Val Asn Trp Leu Glu Gln His Gly Phe Arg Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 
        275                 280                 285             


Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu 
305                 310                 315                 320 


Val Glu Leu Trp Ile Ser Gln Val Asp Ile Asp Leu Met Lys Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Ile Lys Phe Arg Ala 
            340                 345                 350         


Thr Thr Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  105
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 
        275                 280                 285             


Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Leu 
305                 310                 315                 320 


Val Glu Leu Tyr Val Thr Asn Ile Asp Leu Asp Leu Ile Lys Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Leu Lys Phe Arg Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  106
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  107
<211>  582
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  107

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Asp Arg Met Thr Ala Gly Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile 
        195                 200                 205             


Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly 
    210                 215                 220                 


Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu 
225                 230                 235                 240 


Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp 
                245                 250                 255     


Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr 
            260                 265                 270         


Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr 
        275                 280                 285             


Pro Leu His Ile Gln His Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly 
    290                 295                 300                 


Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn 
305                 310                 315                 320 


Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser 
                325                 330                 335     


Asn Val Asp Leu Glu Leu Met Lys Glu His Tyr Asp Leu Tyr Asn Val 
            340                 345                 350         


Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys 
        355                 360                 365             


Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala 
    370                 375                 380                 


Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe 
385                 390                 395                 400 


Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn 
                405                 410                 415     


Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val 
            420                 425                 430         


Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr 
        435                 440                 445             


Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr 
    450                 455                 460                 


Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp 
465                 470                 475                 480 


Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe 
                485                 490                 495     


Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr 
            500                 505                 510         


Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr 
        515                 520                 525             


Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile 
    530                 535                 540                 


Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys 
545                 550                 555                 560 


Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp 
                565                 570                 575     


Glu Thr Phe Thr Ile Lys 
            580         


<210>  108
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  109
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  110
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  110

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  111
<211>  587
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  111

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Asp Arg Met Thr Ala Gly Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile 
        195                 200                 205             


Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly 
    210                 215                 220                 


Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu 
225                 230                 235                 240 


Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp 
                245                 250                 255     


Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr 
            260                 265                 270         


Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr 
        275                 280                 285             


Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg Leu Lys Glu Arg 
    290                 295                 300                 


His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu Phe Ile Gln Asn 
305                 310                 315                 320 


Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val Asp Glu Leu Ile 
                325                 330                 335     


Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu His Tyr 
            340                 345                 350         


Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser 
        355                 360                 365             


Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr 
    370                 375                 380                 


Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser 
385                 390                 395                 400 


Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro 
                405                 410                 415     


Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu 
            420                 425                 430         


Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp 
        435                 440                 445             


Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile 
    450                 455                 460                 


Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro 
465                 470                 475                 480 


Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu 
                485                 490                 495     


His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr 
            500                 505                 510         


Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly 
        515                 520                 525             


Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly 
    530                 535                 540                 


Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val 
545                 550                 555                 560 


Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly 
                565                 570                 575     


Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
            580                 585         


<210>  112
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  112

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  113
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  113

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  114
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  114

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln 
            260                 265                 270         


Gly Lys Tyr Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile 
        275                 280                 285             


Arg Phe Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Lys Asn Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly 
305                 310                 315                 320 


Val Glu Pro Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile 
                325                 330                 335     


Gln Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys 
            340                 345                 350         


Phe Arg Glu Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  115
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  115

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 
            260                 265                 270         


Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 
    290                 295                 300                 


Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 
305                 310                 315                 320 


Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 
                325                 330                 335     


Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 
            340                 345                 350         


Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  116
<211>  576
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  116

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 
            20                  25                  30          


Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 
        35                  40                  45              


Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 
65                  70                  75                  80  


Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 
                85                  90                  95      


Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 
            100                 105                 110         


Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 
145                 150                 155                 160 


Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe 
            260                 265                 270         


Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His 
        275                 280                 285             


Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln 
    290                 295                 300                 


Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser 
305                 310                 315                 320 


Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu 
                325                 330                 335     


Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu 
            340                 345                 350         


Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp 
        355                 360                 365             


Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 
    370                 375                 380                 


Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 
385                 390                 395                 400 


Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 
                405                 410                 415     


Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val 
            420                 425                 430         


Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala 
        435                 440                 445             


Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 
    450                 455                 460                 


Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys 
465                 470                 475                 480 


Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 
                485                 490                 495     


Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly 
            500                 505                 510         


Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 
        515                 520                 525             


Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe 
    530                 535                 540                 


Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 
545                 550                 555                 560 


Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575     


<210>  117
<211>  576
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  117

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe Glu 
            260                 265                 270         


Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys Leu 
        275                 280                 285             


Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln Leu 
    290                 295                 300                 


Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser Ser 
305                 310                 315                 320 


Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu Leu 
                325                 330                 335     


Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly Trp 
            340                 345                 350         


Lys Phe Arg Ser Thr Lys Gln Ala Phe Lys Asp Phe Ile Asp Lys Trp 
        355                 360                 365             


Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 
    370                 375                 380                 


Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 
385                 390                 395                 400 


Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 
                405                 410                 415     


Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val 
            420                 425                 430         


Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala 
        435                 440                 445             


Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 
    450                 455                 460                 


Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys 
465                 470                 475                 480 


Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 
                485                 490                 495     


Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly 
            500                 505                 510         


Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 
        515                 520                 525             


Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe 
    530                 535                 540                 


Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 
545                 550                 555                 560 


Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575     


<210>  118
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  118

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 
            20                  25                  30          


Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 
        35                  40                  45              


Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 
65                  70                  75                  80  


Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 
                85                  90                  95      


Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 
            100                 105                 110         


Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 
145                 150                 155                 160 


Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe 
            260                 265                 270         


Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys 
        275                 280                 285             


Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln 
    290                 295                 300                 


Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser 
305                 310                 315                 320 


Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu 
                325                 330                 335     


Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly 
            340                 345                 350         


Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  119
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  119

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Phe Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  120
<211>  582
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  120

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 
    50                  55                  60                  


Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 
                85                  90                  95      


Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 
            100                 105                 110         


Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 
        115                 120                 125             


Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 
    130                 135                 140                 


Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 
145                 150                 155                 160 


Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 
                165                 170                 175     


Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 
            180                 185                 190         


Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Phe Lys Asp Ile 
        195                 200                 205             


Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly 
    210                 215                 220                 


Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu 
225                 230                 235                 240 


Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp 
                245                 250                 255     


Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr 
            260                 265                 270         


Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr 
        275                 280                 285             


Pro Leu His Ile Gln His Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly 
    290                 295                 300                 


Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn 
305                 310                 315                 320 


Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser 
                325                 330                 335     


Asn Val Asp Leu Glu Leu Met Lys Glu His Tyr Asp Leu Tyr Asn Val 
            340                 345                 350         


Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys 
        355                 360                 365             


Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala 
    370                 375                 380                 


Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe 
385                 390                 395                 400 


Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn 
                405                 410                 415     


Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val 
            420                 425                 430         


Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr 
        435                 440                 445             


Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr 
    450                 455                 460                 


Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp 
465                 470                 475                 480 


Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe 
                485                 490                 495     


Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr 
            500                 505                 510         


Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr 
        515                 520                 525             


Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile 
    530                 535                 540                 


Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys 
545                 550                 555                 560 


Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp 
                565                 570                 575     


Glu Thr Phe Thr Ile Lys 
            580         


<210>  121
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  121

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  122
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  122

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  123
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  123

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Lys Val Arg Gly Tyr Leu Val Gln 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  124
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  124

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 
    450                 455                 460                 


Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Val Lys Lys Val Arg Gly Tyr Leu Val Gln 
            500                 505                 510         


Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  125
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  125

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 
    290                 295                 300                 


Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  126
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  126

Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 
1               5                   10                  15      


Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 
            20                  25                  30          


Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 
        35                  40                  45              


Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  127
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  127

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  128
<211>  596
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  128

Met Val Arg Gln Ser Thr Ile Ala Ser Pro Ala Arg Gly Gly Val Arg 
1               5                   10                  15      


Arg Ser His Lys Lys Val Pro Ser Phe Cys Ala Asp Phe Glu Thr Thr 
            20                  25                  30          


Thr Asp Glu Asp Asp Cys Arg Val Trp Ser Trp Gly Ile Ile Gln Val 
        35                  40                  45              


Gly Lys Leu Gln Asn Tyr Val Asp Gly Ile Ser Leu Asp Gly Phe Met 
    50                  55                  60                  


Ser His Ile Ser Glu Arg Ala Ser His Ile Tyr Phe His Asp Leu Lys 
65                  70                  75                  80  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
                85                  90                  95      


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
            100                 105                 110         


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
        115                 120                 125             


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
    130                 135                 140                 


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
145                 150                 155                 160 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
                165                 170                 175     


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
            180                 185                 190         


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
        195                 200                 205             


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
    210                 215                 220                 


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
225                 230                 235                 240 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
                245                 250                 255     


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
            260                 265                 270         


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
        275                 280                 285             


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
    290                 295                 300                 


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
305                 310                 315                 320 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
                325                 330                 335     


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
            340                 345                 350         


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
        355                 360                 365             


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
    370                 375                 380                 


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
385                 390                 395                 400 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
                405                 410                 415     


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
            420                 425                 430         


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
        435                 440                 445             


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
    450                 455                 460                 


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
465                 470                 475                 480 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
                485                 490                 495     


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
            500                 505                 510         


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
        515                 520                 525             


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
    530                 535                 540                 


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
545                 550                 555                 560 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
                565                 570                 575     


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
            580                 585                 590         


Phe Thr Ile Lys 
        595     


<210>  129
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  129

Met Asn Glu Tyr Ile Ser Asp Phe Glu Thr Gln Lys Asp Pro Asp Thr 
1               5                   10                  15      


Gly Val Met Ser Val Trp Ala Trp Ser Ile Val Asp Val Asn Asp Leu 
            20                  25                  30          


Ser Asn Ile Gln Tyr Gly Asn Asn Ile Glu Ser Trp Leu Ser Ala Ile 
        35                  40                  45              


Gln Gly Leu Pro Asn Gly Ser Leu Ile Gly Phe His Asp Leu Lys Phe 
    50                  55                  60                  


Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp 
65                  70                  75                  80  


Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys 
    290                 295                 300                 


Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  130
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  130

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  131
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  131

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp 
        355                 360                 365             


Ile Asp Lys Trp Ile Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys 
    370                 375                 380                 


Ala Asn Ala Lys Gly Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu 
    530                 535                 540                 


Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys 
545                 550                 555                 560 


Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  132
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  132

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr 
385                 390                 395                 400 


Asn Pro Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile 
                405                 410                 415     


Val Arg Leu Thr Leu Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu 
    530                 535                 540                 


Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys 
545                 550                 555                 560 


Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  133
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  133

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Tyr Ser Glu 
            260                 265                 270         


Gly Ala Pro Arg Thr Asn Arg Pro Leu Tyr Ile Ala Ser Ile Thr Phe 
        275                 280                 285             


Thr Ala Lys Leu Lys Pro Asn His Ile Pro Cys Ile Gln Ile Lys Lys 
    290                 295                 300                 


Asn Leu Ser Phe Asn Pro Thr Gln Tyr Leu Glu Glu Val Lys Glu Pro 
305                 310                 315                 320 


Thr Thr Val Val Ala Thr Asn Ile Asp Ile Glu Leu Trp Lys Lys His 
                325                 330                 335     


Tyr Asp Phe Lys Ile Tyr Ser Trp Asn Gly Thr Phe Glu Phe Arg Gly 
            340                 345                 350         


Ser His Gly Phe Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570         


<210>  134
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  134

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Ile Gly Thr Pro Val Phe Phe Glu 
            260                 265                 270         


Gly Lys Tyr Lys Asp Asp Pro Ile Tyr Pro Leu Tyr Ile Gln Phe Ile 
        275                 280                 285             


Thr Ala Gln Phe Glu Leu Lys Lys Gly Lys Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Asn Asp Lys Arg Phe Asn Pro Arg Glu Tyr Val Thr Ser Thr Gly 
305                 310                 315                 320 


Cys Leu Met Val Asn Leu Tyr Leu Thr Asn Val Asp Leu Glu Met Phe 
                325                 330                 335     


Tyr Glu Cys Tyr Asn Ile Lys Glu Ile Gln Tyr Ile Gly Gly Tyr Lys 
            340                 345                 350         


Phe Ile Gly Arg Ser Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 
                565                 570                 575 


<210>  135
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  135

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  136
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  136

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  137
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  137

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  138
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  138

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Thr Leu Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  139
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  139

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  140
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  140

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  141
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  141

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  142
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  142

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  143
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  143

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  144
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  144

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  145
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  145

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  146
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  146

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  147
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  147

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  148
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  148

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  149
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  149

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  150
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  150

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  151
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  151

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  152
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  152

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  153
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  153

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  154
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  154

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  155
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  155

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  156
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  156

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  157
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  157

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  158
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  158

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  159
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  159

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  160
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  160

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  161
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  161

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  162
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  162

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  163
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  163

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  164
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  164

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  165
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  165

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  166
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  166

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  167
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  167

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  168
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  168

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  169
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  169

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  170
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  170

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  171
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  171

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  172
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  172

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  173
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  173

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  174
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  174

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  175
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  175

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  176
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  176

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  177
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  177

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  178
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  178

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  179
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  179

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  180
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  180

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  181
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  181

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  182
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  182

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  183
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  183

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  184
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  184

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 
            500                 505                 510         


Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  185
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  185

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  186
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  186

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 
            500                 505                 510         


Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  187
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  187

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  188
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  188

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  189
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  189

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  190
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  190

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  191
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  191

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  192
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  192

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  193
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  193

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  194
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  194

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  195
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  195

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  196
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  196

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  197
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  197

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr 
145                 150                 155                 160 


Ala Tyr Leu Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  198
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  198

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr 
145                 150                 155                 160 


Ala Tyr Leu Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  199
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  199

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Ile Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 
            100                 105                 110         


His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr 
145                 150                 155                 160 


Ala Tyr Leu Lys Asn Asp Ile Gln Ile Leu Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  200
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  200

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  201
<211>  616
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  201

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys Gly His His His His His His His His His His Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 
        595                 600                 605             


Ala Gln Lys Ile Glu Trp His Glu 
    610                 615     


<210>  202
<211>  616
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  202

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu His Asn Gly Tyr Thr Trp Thr Lys 
65                  70                  75                  80  


Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys Gly His His His His His His His His His His Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 
        595                 600                 605             


Ala Gln Lys Ile Glu Trp His Glu 
    610                 615     


<210>  203
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  203

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu His Lys Gly Tyr Glu Cys Asn Glu 
65                  70                  75                  80  


Ser Gly Arg Pro Lys Thr Phe Asp Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  204
<211>  616
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  204

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu Lys His Gly Tyr Arg Trp Thr Lys 
65                  70                  75                  80  


Glu Asn Pro Gly Val Lys Glu Phe Thr Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys Gly His His His His His His His His His His Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 
        595                 600                 605             


Ala Gln Lys Ile Glu Trp His Glu 
    610                 615     


<210>  205
<211>  616
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  205

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys Gly His His His His His His His His His His Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 
        595                 600                 605             


Ala Gln Lys Ile Glu Trp His Glu 
    610                 615     


<210>  206
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  206

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Thr Ala 
65                  70                  75                  80  


Glu Gly Glu Pro Asn Thr Tyr Ser Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  207
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  207

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu Lys Asn Gly Phe Lys Trp Thr Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Arg Thr Tyr Ser Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  208
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  208

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Tyr Lys Trp Thr Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Phe Ser Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  209
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  209

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Lys Asn Gly Tyr Lys Trp Thr Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Lys Thr Phe Ser Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  210
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  210

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu Arg Asn Gly Tyr Val His Thr Glu 
65                  70                  75                  80  


Glu Asp Arg Thr Asn Thr Pro Lys Glu Phe Thr Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  211
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  211

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp 
65                  70                  75                  80  


Glu Lys Ala Pro Gln Val Lys Glu Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys 
    290                 295                 300                 


Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  212
<211>  618
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  212

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu Thr Asp Gly Trp Lys Trp Ile Pro 
65                  70                  75                  80  


Asp Lys Asn Asp Cys Ala Asn Arg Thr Phe Thr Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys Gly His His His His His His His His His His Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 
        595                 600                 605             


Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615             


<210>  213
<211>  617
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  213

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu Glu Asn Gly Phe Lys His Ser Arg 
65                  70                  75                  80  


Glu Arg Ala Leu Tyr Ser Asn Glu Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys 
    290                 295                 300                 


Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe 
                565                 570                 575     


Thr Ile Lys Gly His His His His His His His His His His Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe 
        595                 600                 605             


Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615         


<210>  214
<211>  619
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  214

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Leu Gly Val Ala Lys Trp Glu Tyr Asn 
65                  70                  75                  80  


Asp Lys Pro Lys Ala Arg Lys Ala Lys Thr Val Glu Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu 
                565                 570                 575     


Thr Phe Thr Ile Lys Gly His His His His His His His His His His 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp 
        595                 600                 605             


Phe Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    610                 615                 


<210>  215
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  215

Met Ser Arg Lys Met Tyr Ser Ala Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ser Tyr Gly Trp Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  216
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  216

Met Ser Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Val Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  217
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  217

Met Ser Arg Lys Val Phe Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  218
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  218

Met Ser Arg Lys Val Tyr Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  219
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  219

Met Ser Arg Lys Met Tyr Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  220
<211>  615
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  220

Met Ser Arg Lys Met Tyr Ser Ala Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys Gly His His His His His His His His His His Gly Gly Gly Ser 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 
        595                 600                 605             


Gln Lys Ile Glu Trp His Glu 
    610                 615 


<210>  221
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  221

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  222
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  222

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Asn His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  223
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  223

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Gln His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  224
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  224

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Phe Tyr Ile Lys Thr Arg Ser Glu Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  225
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  225

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  226
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  226

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  227
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  227

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  228
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  228

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  229
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  229

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  230
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  230

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  231
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  231

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  232
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  232

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  233
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  233

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  234
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  234

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  235
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  235

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  236
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  236

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  237
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  237

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  238
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  238

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  239
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  239

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  240
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  240

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  241
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  241

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  242
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  242

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  243
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  243

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  244
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  244

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  245
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  245

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  246
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  246

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  247
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  247

Met His Lys Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ile Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  248
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  248

Met His Lys Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Val Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  249
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  249

Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  250
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  250

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  251
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  251

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  252
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  252

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  253
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  253

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  254
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  254

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  255
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  255

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  256
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  256

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Thr Leu Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  257
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  257

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  258
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  258

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  259
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  259

Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  260
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  260

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  261
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  261

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  262
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  262

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  263
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  263

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  264
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  264

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  265
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  265

Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  266
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  266

Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  267
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  267

Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Gln Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  268
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  268

Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Gln Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  269
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  269

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  270
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  270

Met His Lys Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ile Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  271
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  271

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  272
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  272

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  273
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  273

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  274
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  274

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  275
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  275

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  276
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  276

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  277
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  277

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  278
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  278

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Leu His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  279
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  279

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp 
                325                 330                 335     


Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  280
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  280

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  281
<211>  579
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  281

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 
    50                  55                  60                  


Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 
                85                  90                  95      


Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 
            100                 105                 110         


Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 
        115                 120                 125             


Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 
    130                 135                 140                 


Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 
145                 150                 155                 160 


Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 
                165                 170                 175     


Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 
            180                 185                 190         


Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 
        195                 200                 205             


Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 
    210                 215                 220                 


Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 
225                 230                 235                 240 


Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 
                245                 250                 255     


Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 
            260                 265                 270         


Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 
        275                 280                 285             


Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 
    290                 295                 300                 


Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 
305                 310                 315                 320 


Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp 
                325                 330                 335     


Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 
            340                 345                 350         


Tyr Gly Tyr Met Phe Arg Ser Ser Cys Asp Met Phe Lys Asp Phe Ile 
        355                 360                 365             


Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 
    370                 375                 380                 


Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 
385                 390                 395                 400 


Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 
                405                 410                 415     


Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 
            420                 425                 430         


Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 
        435                 440                 445             


Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 
    450                 455                 460                 


His Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His 
465                 470                 475                 480 


Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 
                485                 490                 495     


Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 
            500                 505                 510         


Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 
        515                 520                 525             


Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 
    530                 535                 540                 


Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 
545                 550                 555                 560 


Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 
                565                 570                 575     


Thr Ile Lys 
            


<210>  282
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  282

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  283
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  283

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  284
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  284

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  285
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  285

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  286
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  286

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  287
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  287

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  288
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  288

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  289
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  289

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  290
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  290

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  291
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  291

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  292
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  292

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  293
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  293

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  294
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  294

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Leu His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  295
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  295

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  296
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  296

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  297
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  297

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ser Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  298
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  298

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  299
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  299

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  300
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  300

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys 
            260                 265                 270         


Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys 
        275                 280                 285             


Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys 
            340                 345                 350         


Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  301
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  301

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala Met Met 
                245                 250                 255     


Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys Gly Glu 
            260                 265                 270         


Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys 
        275                 280                 285             


Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly 
    290                 295                 300                 


Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu 
305                 310                 315                 320 


Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys 
                325                 330                 335     


His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys 
            340                 345                 350         


Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met Glu Ile 
        355                 360                 365             


Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 
            420                 425                 430         


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  302
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  302

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys 
        275                 280                 285             


Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly 
    290                 295                 300                 


Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu 
305                 310                 315                 320 


Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys 
                325                 330                 335     


His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys 
            340                 345                 350         


Gly Phe Ile Gly Phe Phe Asp Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  303
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  303

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys 
            260                 265                 270         


Tyr Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe 
        275                 280                 285             


Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys 
    290                 295                 300                 


Asn Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu 
305                 310                 315                 320 


Pro Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu 
                325                 330                 335     


His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg 
            340                 345                 350         


Glu Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  304
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  304

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  305
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  305

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Pro Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Glu Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  306
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  306

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  307
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  307

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  308
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  308

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  309
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  309

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys 
            340                 345                 350         


Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  310
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  310

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  311
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  311

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys 
            340                 345                 350         


Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  312
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  312

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  313
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  313

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  314
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  314

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Tyr Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  315
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  315

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  316
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  316

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  317
<211>  574
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  317

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Leu Pro Val Pro Phe Ser Gly Glu 
            260                 265                 270         


Tyr Glu Tyr Asp Glu Thr His Pro Leu Phe Ile Gln His Ile Lys Cys 
        275                 280                 285             


Gly Phe Glu Leu Lys Asp Gly His Ile Pro Thr Ile Gln Ile Lys Lys 
    290                 295                 300                 


Asn Phe Arg Phe Ala Asp Asn Glu Tyr Leu His Ser Ser Glu Gly Asn 
305                 310                 315                 320 


Ile Leu Asp Leu His Val Thr Asn Val Asp Leu Ala Leu Ile Lys Glu 
                325                 330                 335     


His Tyr Thr Leu Tyr Glu Glu Glu Tyr Leu Gln Gly Tyr Lys Phe Lys 
            340                 345                 350         


Gln Val Thr Gly Leu Phe Lys Asn Tyr Ile Asp Tyr Trp Ser Asp Lys 
        355                 360                 365             


Lys Ile Asn Ala Glu Asp Pro Ala Ile Arg Gln Met Ala Lys Leu Met 
    370                 375                 380                 


Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly 
385                 390                 395                 400 


Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly 
                405                 410                 415     


Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val 
            420                 425                 430         


Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr 
        435                 440                 445             


Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr 
    450                 455                 460                 


Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly 
465                 470                 475                 480 


Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln 
                485                 490                 495     


Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu 
            500                 505                 510         


Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys 
        515                 520                 525             


Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn 
    530                 535                 540                 


Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val 
545                 550                 555                 560 


Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 


<210>  318
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  318

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  319
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  319

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  320
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  320

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  321
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  321

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  322
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  322

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  323
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  323

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala Met Met 
                245                 250                 255     


Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys Gly Glu 
            260                 265                 270         


Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys 
        275                 280                 285             


Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly 
    290                 295                 300                 


Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu 
305                 310                 315                 320 


Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys 
                325                 330                 335     


His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys 
            340                 345                 350         


Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met Glu Ile 
        355                 360                 365             


Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 
            420                 425                 430         


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  324
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  324

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  325
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  325

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  326
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  326

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Tyr Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  327
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  327

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  328
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  328

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  329
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  329

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  330
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  330

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  331
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  331

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  332
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  332

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  333
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  333

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  334
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  334

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  335
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  335

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  336
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  336

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  337
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  337

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  338
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  338

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  339
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  339

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  340
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  340

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  341
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  341

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  342
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  342

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  343
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  343

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys 
            260                 265                 270         


Gly Glu Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val 
        275                 280                 285             


Arg Cys Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile 
    290                 295                 300                 


Lys Gly Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly 
305                 310                 315                 320 


Asp Glu Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile 
                325                 330                 335     


Lys Lys His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met 
            340                 345                 350         


Phe Lys Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  344
<211>  576
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  344

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe 
            260                 265                 270         


Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His 
        275                 280                 285             


Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln 
    290                 295                 300                 


Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser 
305                 310                 315                 320 


Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu 
                325                 330                 335     


Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu 
            340                 345                 350         


Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp 
        355                 360                 365             


Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 
    370                 375                 380                 


Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 
385                 390                 395                 400 


Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 
                405                 410                 415     


Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser 
            420                 425                 430         


Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala 
        435                 440                 445             


Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 
    450                 455                 460                 


Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys 
465                 470                 475                 480 


Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 
                485                 490                 495     


Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly 
            500                 505                 510         


Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 
        515                 520                 525             


Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe 
    530                 535                 540                 


Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 
545                 550                 555                 560 


Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575     


<210>  345
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  345

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  346
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  346

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  347
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  347

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  348
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  348

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln Ser 
    290                 295                 300                 


Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  349
<211>  576
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  349

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe 
            260                 265                 270         


Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His 
        275                 280                 285             


Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln 
    290                 295                 300                 


Ile Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser 
305                 310                 315                 320 


Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu 
                325                 330                 335     


Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu 
            340                 345                 350         


Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp 
        355                 360                 365             


Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 
    370                 375                 380                 


Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 
385                 390                 395                 400 


Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 
                405                 410                 415     


Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val 
            420                 425                 430         


Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala 
        435                 440                 445             


Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 
    450                 455                 460                 


Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys 
465                 470                 475                 480 


Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 
                485                 490                 495     


Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly 
            500                 505                 510         


Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 
        515                 520                 525             


Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe 
    530                 535                 540                 


Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 
545                 550                 555                 560 


Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575     


<210>  350
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  350

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  351
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  351

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 
            260                 265                 270         


Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 
        275                 280                 285             


Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln Ser 
    290                 295                 300                 


Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 
305                 310                 315                 320 


Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 
                325                 330                 335     


Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 
            340                 345                 350         


Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 
        355                 360                 365             


Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 
    370                 375                 380                 


Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 
385                 390                 395                 400 


Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 
                405                 410                 415     


Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 
            420                 425                 430         


Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 
        435                 440                 445             


Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile 
    450                 455                 460                 


Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 
                485                 490                 495     


Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val Gln 
            500                 505                 510         


Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 
        515                 520                 525             


Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys 
    530                 535                 540                 


Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 
545                 550                 555                 560 


Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570         


<210>  352
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  352

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys 
            260                 265                 270         


Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys 
        275                 280                 285             


Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln 
    290                 295                 300                 


Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys 
            340                 345                 350         


Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  353
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  353

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 
            420                 425                 430         


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  354
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  354

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  355
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  355

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 
            420                 425                 430         


Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  356
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  356

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  357
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  357

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  358
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  358

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  359
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  359

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  360
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  360

Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  361
<211>  575
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  361

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 
            260                 265                 270         


Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu 
        275                 280                 285             


Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile 
    290                 295                 300                 


Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 
305                 310                 315                 320 


Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 
                325                 330                 335     


Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 
            340                 345                 350         


Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 
        355                 360                 365             


Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 
    370                 375                 380                 


Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 
385                 390                 395                 400 


Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 
                405                 410                 415     


Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 
            420                 425                 430         


Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 
        435                 440                 445             


Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 
    450                 455                 460                 


Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 
465                 470                 475                 480 


Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 
                485                 490                 495     


Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 
            500                 505                 510         


Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 
        515                 520                 525             


Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 
    530                 535                 540                 


Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 
545                 550                 555                 560 


Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570                 575 


<210>  362
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  362

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  363
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  363

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  364
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  364

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  365
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  365

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  366
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  366

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  367
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  367

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  368
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  368

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  369
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  369

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  370
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  370

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  371
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  371

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Val Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  372
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  372

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  373
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  373

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  374
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  374

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  375
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  375

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  376
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  376

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Val 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  377
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  377

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  378
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  378

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  379
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  379

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  380
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  380

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  381
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  381

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Asp Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  382
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  382

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Leu Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  383
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  383

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  384
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  384

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  385
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  385

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  386
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  386

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  387
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  387

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  388
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  388

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  389
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  389

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  390
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  390

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  391
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  391

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  392
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  392

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  393
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  393

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  394
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  394

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  395
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  395

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  396
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  396

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  397
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  397

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  398
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  398

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  399
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  399

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  400
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  400

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  401
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  401

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  402
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  402

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Arg Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Asp Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  403
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  403

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  404
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  404

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 
        115                 120                 125             


Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  405
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  405

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  406
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  406

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  407
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  407

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  408
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  408

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  409
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  409

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  410
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  410

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  411
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  411

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  412
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  412

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  413
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  413

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  414
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  414

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  415
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  415

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  416
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  416

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  417
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  417

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  418
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  418

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  419
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  419

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  420
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  420

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  421
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  421

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  422
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  422

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  423
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  423

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  424
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  424

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  425
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  425

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  426
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  426

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  427
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  427

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  428
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  428

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  429
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  429

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  430
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  430

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  431
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  431

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  432
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  432

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  433
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  433

Met Lys His Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  434
<211>  581
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  434

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 
                85                  90                  95      


Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 
            100                 105                 110         


Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 
        115                 120                 125             


Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 
    130                 135                 140                 


Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 
145                 150                 155                 160 


Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 
                165                 170                 175     


Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 
            180                 185                 190         


Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 
        195                 200                 205             


Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 
    210                 215                 220                 


Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 
225                 230                 235                 240 


Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 
                245                 250                 255     


Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 
            260                 265                 270         


Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 
        275                 280                 285             


Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 
    290                 295                 300                 


Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 
305                 310                 315                 320 


Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 
                325                 330                 335     


Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 
            340                 345                 350         


Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 
        355                 360                 365             


Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 
    370                 375                 380                 


Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 
385                 390                 395                 400 


Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 
                405                 410                 415     


Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 
            420                 425                 430         


Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 
        435                 440                 445             


Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 
    450                 455                 460                 


Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu 
465                 470                 475                 480 


Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 
                485                 490                 495     


Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met 
            500                 505                 510         


Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 
        515                 520                 525             


Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 
    530                 535                 540                 


Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 
545                 550                 555                 560 


Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 
                565                 570                 575     


Val Phe Thr Ile Lys 
            580     


<210>  435
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  435

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  436
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  436

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  437
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  437

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  438
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  438

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  439
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  439

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  440
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  440

Met Lys His Met Ser Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 
            20                  25                  30          


Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  441
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  441

Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 
1               5                   10                  15      


Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  442
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  442

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 
            20                  25                  30          


Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  443
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  443

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala 
        35                  40                  45              


Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  444
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  444

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 
            20                  25                  30          


Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala 
        35                  40                  45              


Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  445
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  445

Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 
1               5                   10                  15      


Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala 
        35                  40                  45              


Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  446
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  446

Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 
1               5                   10                  15      


Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 
            20                  25                  30          


Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 
385                 390                 395                 400 


Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 
                405                 410                 415     


Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  447
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  447

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 
            20                  25                  30          


Gly Asn Leu Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Lys Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  448
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  448

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 
            20                  25                  30          


Gly Asn His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Gln Trp Ala Met Lys Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 
385                 390                 395                 400 


Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 
                405                 410                 415     


Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 
    530                 535                 540                 


Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 
545                 550                 555                 560 


Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  449
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  449

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  450
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  450

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg 
                405                 410                 415     


Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu 
545                 550                 555                 560 


Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  451
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  451

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg 
                405                 410                 415     


Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  452
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  452

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg 
                405                 410                 415     


Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu 
545                 550                 555                 560 


Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  453
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  453

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 
            420                 425                 430         


Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  454
<211>  580
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  454

Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 
1               5                   10                  15      


Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 
            20                  25                  30          


Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 
        35                  40                  45              


Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 
    50                  55                  60                  


Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 
65                  70                  75                  80  


Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 
                85                  90                  95      


Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 
            100                 105                 110         


Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 
        115                 120                 125             


Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 
    130                 135                 140                 


Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 
145                 150                 155                 160 


Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 
                165                 170                 175     


Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 
            180                 185                 190         


Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 
        195                 200                 205             


Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 
    210                 215                 220                 


Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 
225                 230                 235                 240 


Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 
                245                 250                 255     


Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 
            260                 265                 270         


Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 
        275                 280                 285             


Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 
    290                 295                 300                 


Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 
305                 310                 315                 320 


Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 
                325                 330                 335     


Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 
            340                 345                 350         


Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 
        355                 360                 365             


Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 
    370                 375                 380                 


Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr 
385                 390                 395                 400 


Asn Pro Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile 
                405                 410                 415     


Val Arg Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 
            420                 425                 430         


Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 
        435                 440                 445             


Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 
    450                 455                 460                 


Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 
465                 470                 475                 480 


His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 
                485                 490                 495     


Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 
            500                 505                 510         


Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 
        515                 520                 525             


Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu 
    530                 535                 540                 


Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys 
545                 550                 555                 560 


Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met 
                565                 570                 575     


Phe Thr Ile Lys 
            580 


<210>  455
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  455

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 
    530                 535                 540                 


Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 
545                 550                 555                 560 


Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  456
<211>  577
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  456

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 
65                  70                  75                  80  


Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 
                85                  90                  95      


Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 
            100                 105                 110         


His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 
        115                 120                 125             


Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 
    130                 135                 140                 


Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 
145                 150                 155                 160 


Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 
                165                 170                 175     


Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 
            180                 185                 190         


Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 
        195                 200                 205             


Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 
    210                 215                 220                 


Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 
225                 230                 235                 240 


Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 
                245                 250                 255     


Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 
            260                 265                 270         


Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 
        275                 280                 285             


Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 
    290                 295                 300                 


Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 
305                 310                 315                 320 


Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 
                325                 330                 335     


Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 
            340                 345                 350         


Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 
        355                 360                 365             


Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 
    370                 375                 380                 


Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 
385                 390                 395                 400 


Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 
                405                 410                 415     


Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 
            420                 425                 430         


Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 
        435                 440                 445             


Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 
    450                 455                 460                 


Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 
465                 470                 475                 480 


Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 
                485                 490                 495     


Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 
            500                 505                 510         


Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 
        515                 520                 525             


Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 
    530                 535                 540                 


Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 
545                 550                 555                 560 


Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 
                565                 570                 575     


Lys 
    


<210>  457
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  457

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln 
    290                 295                 300                 


Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  458
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  458

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  459
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  459

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 
    290                 295                 300                 


Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  460
<211>  573
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  460

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 
    290                 295                 300                 


Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 
305                 310                 315                 320 


Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 
                325                 330                 335     


His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 
            340                 345                 350         


Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 
        355                 360                 365             


Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 
    370                 375                 380                 


Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 
385                 390                 395                 400 


Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 
                405                 410                 415     


Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 
            420                 425                 430         


Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 
        435                 440                 445             


Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 
    450                 455                 460                 


Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 
465                 470                 475                 480 


Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 
                485                 490                 495     


Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 
            500                 505                 510         


Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 
        515                 520                 525             


Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 
    530                 535                 540                 


Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 
545                 550                 555                 560 


Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 
                565                 570             


<210>  461
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  461

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  462
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  462

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  463
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  463

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  464
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  464

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Val Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  465
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  465

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Val Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  466
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  466

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  467
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  467

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 
            420                 425                 430         


Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  468
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  468

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  469
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  469

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  470
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  470

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  471
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  471

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  472
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  472

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  473
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  473

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  474
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  474

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  475
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  475

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  476
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  476

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ile Val Arg 
                405                 410                 415     


Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  477
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  477

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  478
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  478

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  479
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  479

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  480
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  480

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Val Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  481
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  481

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  482
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  482

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  483
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  483

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  484
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  484

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  485
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  485

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  486
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  486

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  487
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  487

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  488
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  488

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  489
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  489

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Val Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  490
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  490

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  491
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  491

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  492
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  492

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  493
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  493

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  494
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  494

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  495
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  495

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  496
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  496

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  497
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  497

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  498
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  498

Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  499
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  499

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 
                405                 410                 415     


Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  500
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  500

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Asp Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  501
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  501

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly 
                405                 410                 415     


Phe Arg Val Gly Asp Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Asp Asn Phe Ala Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  502
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  502

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  503
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  503

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Lys Leu Thr Thr Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  504
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  504

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Gln Arg Thr Ile Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  505
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  505

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Gln Arg Thr Ile Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  506
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  506

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Asn His Val Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  507
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  507

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Asn His Val Val Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  508
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  508

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Gly Thr Thr Gln Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  509
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  509

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Phe Arg Val Glu Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  510
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  510

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Phe Arg Val Glu Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  511
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  511

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  512
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  512

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Pro Lys Tyr Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  513
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  513

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Pro Lys Phe Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  514
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  514

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asn Pro Arg Tyr Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  515
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  515

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asp Pro Lys Tyr Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  516
<211>  578
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  516

Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 
1               5                   10                  15      


Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 
            20                  25                  30          


Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 
        35                  40                  45              


Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 
    50                  55                  60                  


Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 
65                  70                  75                  80  


Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 
                85                  90                  95      


Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 
            100                 105                 110         


Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 
        115                 120                 125             


Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 
    130                 135                 140                 


Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 
145                 150                 155                 160 


Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 
                165                 170                 175     


Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 
            180                 185                 190         


Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 
        195                 200                 205             


Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 
    210                 215                 220                 


Arg Gly Gly Phe Thr Trp Leu Asp Pro Arg Tyr Lys Gly Lys Glu Ile 
225                 230                 235                 240 


Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 
                245                 250                 255     


Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 
            260                 265                 270         


Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 
        275                 280                 285             


Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 
    290                 295                 300                 


Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 
305                 310                 315                 320 


Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 
                325                 330                 335     


Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 
            340                 345                 350         


Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 
        355                 360                 365             


Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 
    370                 375                 380                 


Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 
385                 390                 395                 400 


Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 
                405                 410                 415     


Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 
            420                 425                 430         


Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 
        435                 440                 445             


Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 
    450                 455                 460                 


Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 
465                 470                 475                 480 


Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 
                485                 490                 495     


Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 
            500                 505                 510         


Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 
        515                 520                 525             


Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 
    530                 535                 540                 


Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 
545                 550                 555                 560 


Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 
                565                 570                 575     


Ile Lys 
        


<210>  517
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  517

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp 
1               5                   10                  15      


Phe Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
            20                  25          




<210>  518
<211>  53
<212>  PRT
<213>  Bacillus phage phi29

<400>  518

Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Ile Asn 
1               5                   10                  15      


Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala Asp Gly Leu Pro Asn 
            20                  25                  30          


Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln Trp Tyr Met Ile Asp 
        35                  40                  45              


Ile Cys Leu Gly Tyr  
    50                  


<210>  519
<211>  53
<212>  PRT
<213>  Bacteriophage M2Y

<400>  519

Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly Ala Phe Ile Val Asn 
1               5                   10                  15      


Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn Glu Gly Leu Pro Asn 
            20                  25                  30          


Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln Trp Tyr Met Ile Asp 
        35                  40                  45              


Ile Cys Phe Gly Tyr 
    50              


<210>  520
<211>  54
<212>  PRT
<213>  Lucilia cuprina

<400>  520

Arg Leu Tyr Phe His Asp Leu Lys Phe Asp Gly Ser Phe Ile Val Asn 
1               5                   10                  15      


Trp Leu Leu His Asn Gly Tyr Thr Trp Thr Lys Arg Pro Ser Lys Glu 
            20                  25                  30          


Gly Gln Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Trp Tyr Gly Ile 
        35                  40                  45              


Thr Ile Cys Ser Gly Arg 
    50                  


<210>  521
<211>  54
<212>  PRT
<213>  Enterococcus faecium

<400>  521

Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly Glu Phe Met Leu Ser 
1               5                   10                  15      


Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys Glu Ala Lys Glu Glu 
            20                  25                  30          


Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly Gln Trp Tyr Ala Leu 
        35                  40                  45              


Glu Ile Cys Trp Asn Val 
    50                  


<210>  522
<211>  56
<212>  PRT
<213>  Bacillus phage GA-1

<400>  522

Asp Ile Tyr Phe His Asn Leu Lys Phe Asp Gly Ser Phe Ile Leu Pro 
1               5                   10                  15      


Trp Trp Leu Arg Asn Gly Tyr Val His Thr Glu Glu Asp Arg Thr Asn 
            20                  25                  30          


Thr Pro Lys Glu Phe Thr Thr Thr Ile Ser Gly Met Gly Gln Trp Tyr 
        35                  40                  45              


Ala Val Asp Val Cys Ile Asn Thr 
    50                  55      


<210>  523
<211>  53
<212>  PRT
<213>  Bacillus phage VMY22

<400>  523

Asp Leu Tyr Phe His Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn 
1               5                   10                  15      


Trp Leu Leu His Lys Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys 
            20                  25                  30          


Thr Phe Asp Thr Val Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala 
        35                  40                  45              


Ile His His Glu Gly 
    50              


<210>  524
<211>  54
<212>  PRT
<213>  Actinomyces phage AV-1

<400>  524

His Ile Tyr Phe His Asn Leu Ala Phe Asp Gly Thr Phe Ile Leu Asp 
1               5                   10                  15      


Trp Leu Leu Lys His Gly Tyr Arg Trp Thr Lys Glu Asn Pro Gly Val 
            20                  25                  30          


Lys Glu Phe Thr Ser Leu Ile Ser Arg Met Gly Lys Tyr Tyr Ser Ile 
        35                  40                  45              


Thr Val Val Phe Glu Thr 
    50                  


<210>  525
<211>  55
<212>  PRT
<213>  Globodera sp.

<400>  525

Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu Asp 
1               5                   10                  15      


Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro Gln 
            20                  25                  30          


Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr Ser 
        35                  40                  45              


Ile Lys Val Arg Trp Glu Asn 
    50                  55  


<210>  526
<211>  56
<212>  PRT
<213>  Lynx pardinus

<400>  526

Arg Val Tyr Phe His Asn Leu Lys Phe Asp Gly Lys Phe Ile Leu His 
1               5                   10                  15      


Lys Ile Leu Thr Asp Gly Trp Lys Trp Ile Pro Asp Lys Asn Asp Cys 
            20                  25                  30          


Ala Asn Arg Thr Phe Thr Thr Leu Ile Ser Asp Met Ser Gln Phe Tyr 
        35                  40                  45              


Ser Ile Lys Leu Trp Phe Asp Glu 
    50                  55      


<210>  527
<211>  55
<212>  PRT
<213>  Candidatus Moranbacteria

<400>  527

Glu Val Phe Phe His Asn Leu Lys Tyr Asp Gly Asp Phe Ile Val Lys 
1               5                   10                  15      


Phe Leu Leu Glu Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr 
            20                  25                  30          


Ser Asn Glu Phe Ser Thr Leu Ile Ser Asp Thr Gly Thr Trp Tyr Glu 
        35                  40                  45              


Ile Lys Ile Cys Phe His Ala 
    50                  55  


<210>  528
<211>  57
<212>  PRT
<213>  Eggerthella sp.

<400>  528

Leu Ile Gly Phe His Asn Leu Lys Phe Asp Gly Ser Tyr Ile Leu Ser 
1               5                   10                  15      


Tyr Leu Leu Gly Val Ala Lys Trp Glu Tyr Asn Asp Lys Pro Lys Ala 
            20                  25                  30          


Arg Lys Ala Lys Thr Val Glu Cys Leu Ile Ser Ser Ile Gly Val His 
        35                  40                  45              


Tyr Asn Tyr Arg Ile Asn Phe Thr Lys 
    50                  55          


<210>  529
<211>  12
<212>  PRT
<213>  Bacillus phage phi29

<400>  529

Asn Gly Phe Lys Trp Ser Ala Asp Gly Leu Pro Asn 
1               5                   10          


<210>  530
<211>  12
<212>  PRT
<213>  Bacteriophage M2Y

<400>  530

His Gly Phe Lys Trp Ser Asn Glu Gly Leu Pro Asn 
1               5                   10          


<210>  531
<211>  13
<212>  PRT
<213>  Lucilia cuprina

<400>  531

Asn Gly Tyr Thr Trp Thr Lys Arg Pro Ser Lys Glu Gly 
1               5                   10              


<210>  532
<211>  13
<212>  PRT
<213>  Enterococcus faecium

<400>  532

Asn Gly Phe Lys Trp Cys Lys Glu Ala Lys Glu Glu Arg 
1               5                   10              


<210>  533
<211>  15
<212>  PRT
<213>  Bacillus phage GA-1

<400>  533

Asn Gly Tyr Val His Thr Glu Glu Asp Arg Thr Asn Thr Pro Lys 
1               5                   10                  15  


<210>  534
<211>  12
<212>  PRT
<213>  Bacillus phage VMY22

<400>  534

Lys Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys 
1               5                   10          


<210>  535
<211>  13
<212>  PRT
<213>  Actinomyces phage AV-1

<400>  535

His Gly Tyr Arg Trp Thr Lys Glu Asn Pro Gly Val Lys 
1               5                   10              


<210>  536
<211>  14
<212>  PRT
<213>  Globodera sp.

<400>  536

Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro Gln Val Lys 
1               5                   10                  


<210>  537
<211>  15
<212>  PRT
<213>  Lynx pardinus

<400>  537

Asp Gly Trp Lys Trp Ile Pro Asp Lys Asn Asp Cys Ala Asn Arg 
1               5                   10                  15  


<210>  538
<211>  14
<212>  PRT
<213>  Eggerthella sp.

<400>  538

Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr Ser Asn 
1               5                   10                  


<210>  539
<211>  16
<212>  PRT
<213>  Eggerthella sp.

<400>  539

Val Ala Lys Trp Glu Tyr Asn Asp Lys Pro Lys Ala Arg Lys Ala Lys 
1               5                   10                  15      




