SEQUENCE LISTING

<110>   MEREO BIOPHARMA 3 LIMITED        

<120>   USE OF ANTI-SCLEROSTIN ANTIBODIES IN THE TREATMENT OF
 	  OSTEOGENESIS IMPERFECTA

<130>   P069492-US 

<160>   177

<170>   SeqWin2010, version 1.0

<210>   1
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   1
Gly Phe Thr Phe Ser Ser Tyr Val Met Asn 
1               5                   10  

<210>   2
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   2
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   3
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   3
Gly Phe Thr Phe Ser Ser Tyr Val Met Asn 
1               5                   10  

<210>   4
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   4
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   5
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   5
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   6
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   6
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   7
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   7
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   8
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   8
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   9
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   9
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   10
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   10
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   11
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   11
Gly Phe Thr Phe Arg Ser His Trp Leu Ser 
1               5                   10  

<210>   12
<211>   20
<212>   PRT
<213>   Homo sapiens

<400>   12
Trp Val Ser Phe Ile Ser Gly Asp Ser Ser Asn Thr Tyr Tyr Ala Asp 
1               5                   10                  15      

Ser Val Lys Gly 
            20  

<210>   13
<211>   20
<212>   PRT
<213>   Homo sapiens

<400>   13
Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp 
1               5                   10                  15      

Ser Val Lys Gly 
            20  

<210>   14
<211>   20
<212>   PRT
<213>   Homo sapiens

<400>   14
Trp Val Ser Phe Ile Ser Gly Asp Ser Ser Asn Thr Tyr Tyr Ala Asp 
1               5                   10                  15      

Ser Val Lys Gly 
            20  

<210>   15
<211>   20
<212>   PRT
<213>   Homo sapiens

<400>   15
Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp 
1               5                   10                  15      

Ser Val Lys Gly 
            20  

<210>   16
<211>   19
<212>   PRT
<213>   Homo sapiens

<400>   16
Trp Val Ser Val Thr Gly Val His Gly Asp Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      

Val Lys Gly 
            

<210>   17
<211>   19
<212>   PRT
<213>   Homo sapiens

<400>   17
Trp Val Ser Val Ile Gly Asn Trp Gly Asp Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      

Val Lys Gly 
            

<210>   18
<211>   19
<212>   PRT
<213>   Homo sapiens

<400>   18
Trp Val Ser Val Thr Thr His Gln Gly Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      

Val Lys Gly 
            

<210>   19
<211>   19
<212>   PRT
<213>   Homo sapiens

<400>   19
Trp Val Ser Ala Thr Asn Arg Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      

Val Lys Gly 
            

<210>   20
<211>   20
<212>   PRT
<213>   Homo sapiens

<400>   20
Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp 
1               5                   10                  15      

Ser Val Lys Gly 
            20  

<210>   21
<211>   19
<212>   PRT
<213>   Homo sapiens

<400>   21
Trp Val Ser Val Ile Thr Pro Tyr Gly Asp Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      

Val Lys Gly 
            

<210>   22
<211>   19
<212>   PRT
<213>   Homo sapiens

<400>   22
Trp Val Ser Val Ile Thr Pro Tyr Gly Asp Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      

Val Lys Gly 
            

<210>   23
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   23
Thr Phe Met His Gly His Leu Gly Gly Gly Leu Ser Met Asp Phe 
1               5                   10                  15  

<210>   24
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   24
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   25
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   25
Thr Phe Met His Gly His Leu Gly Gly Gly Leu Ser Met Asp Phe 
1               5                   10                  15  

<210>   26
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   26
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   27
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   27
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   28
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   28
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   29
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   29
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   30
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   30
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   31
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   31
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   32
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   32
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   33
<211>   8
<212>   PRT
<213>   Homo sapiens

<400>   33
Asp Thr Tyr Leu His Phe Asp Tyr 
1               5               

<210>   34
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   34
Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His 
1               5                   10      

<210>   35
<211>   20
<212>   PRT
<213>   Homo sapiens

<400>   35
Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp 
1               5                   10                  15      

Ser Val Lys Gly 
            20  

<210>   36
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   36
Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val His 
1               5                   10      

<210>   37
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   37
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   38
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   38
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   39
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   39
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   40
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   40
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   41
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   41
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   42
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   42
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   43
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   43
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   44
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   44
Thr Gly Thr Ser Ser Asp Val Gly Asp Ile Asn Asp Val Ser 
1               5                   10                  

<210>   45
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   45
Leu Val Ile Tyr Asp Asp Asn Asn Arg Pro Ser 
1               5                   10      

<210>   46
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   46
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   47
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   47
Leu Val Ile Tyr Asp Asp Asn Asn Arg Pro Ser 
1               5                   10      

<210>   48
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   48
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   49
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   49
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   50
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   50
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   51
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   51
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   52
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   52
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   53
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   53
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   54
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   54
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   55
<211>   11
<212>   PRT
<213>   Homo sapiens

<400>   55
Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser 
1               5                   10      

<210>   56
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   56
Gly Ser Trp Ala Gly Ser Ser Gly Ser Tyr 
1               5                   10  

<210>   57
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   57
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   58
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   58
Ala Ser Trp Thr Gly Val Glu Pro Asp Tyr 
1               5                   10  

<210>   59
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   59
Gln Ser Tyr Ala Gly Ser Tyr Leu Ser Glu 
1               5                   10  

<210>   60
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   60
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   61
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   61
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   62
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   62
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   63
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   63
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   64
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   64
Ser Thr Tyr Asp Gly Pro Gly Leu Ser Glu 
1               5                   10  

<210>   65
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   65
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   66
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   66
Ser Ser Tyr Gly Glu Ser Leu Thr Ser Tyr 
1               5                   10  

<210>   67
<211>   124
<212>   PRT
<213>   Homo sapiens

<400>   67
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Phe Ile Ser Gly Asp Ser Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Thr Phe Met His Gly His Leu Gly Gly Gly Leu Ser Met Asp 
            100                 105                 110         

Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210>   68
<211>   117
<212>   PRT
<213>   Homo sapiens

<400>   68
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   69
<211>   124
<212>   PRT
<213>   Homo sapiens

<400>   69
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          

Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Phe Ile Ser Gly Asp Ser Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Thr Phe Met His Gly His Leu Gly Gly Gly Leu Ser Met Asp 
            100                 105                 110         

Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210>   70
<211>   117
<212>   PRT
<213>   Homo sapiens

<400>   70
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   71
<211>   116
<212>   PRT
<213>   Homo sapiens

<400>   71
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Val Thr Gly Val His Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      

Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>   72
<211>   116
<212>   PRT
<213>   Homo sapiens

<400>   72
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Val Ile Gly Asn Trp Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      

Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>   73
<211>   116
<212>   PRT
<213>   Homo sapiens

<400>   73
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Val Thr Thr His Gln Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      

Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>   74
<211>   116
<212>   PRT
<213>   Homo sapiens

<400>   74
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Ala Thr Asn Arg Tyr Gly Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      

Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>   75
<211>   117
<212>   PRT
<213>   Homo sapiens

<400>   75
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser 
        115         

<210>   76
<211>   116
<212>   PRT
<213>   Homo sapiens

<400>   76
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Val Ile Thr Pro Tyr Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      

Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>   77
<211>   116
<212>   PRT
<213>   Homo sapiens

<400>   77
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Val Ile Thr Pro Tyr Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      

Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         

Thr Val Ser Ser 
        115     

<210>   78
<211>   110
<212>   PRT
<213>   Homo sapiens

<400>   78
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      

Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Ala Gly Ser Ser Gly Ser 
                85                  90                  95      

Tyr Val Phe Gly Gly Arg Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210>   79
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   79
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Glu Ser 
                85                  90                  95      

Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   80
<211>   110
<212>   PRT
<213>   Homo sapiens

<400>   80
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      

Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Phe Tyr Val 
            20                  25                  30          

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              

Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  

Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Thr Gly Val Glu Pro Asp 
                85                  90                  95      

Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110 

<210>   81
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   81
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ser 
                85                  90                  95      

Tyr Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   82
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   82
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Glu Ser 
                85                  90                  95      

Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   83
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   83
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Glu Ser 
                85                  90                  95      

Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   84
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   84
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Glu Ser 
                85                  90                  95      

Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   85
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   85
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Glu Ser 
                85                  90                  95      

Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   86
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   86
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Tyr Asp Gly Pro 
                85                  90                  95      

Gly Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   87
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   87
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Glu Ser 
                85                  90                  95      

Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   88
<211>   113
<212>   PRT
<213>   Homo sapiens

<400>   88
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Tyr Asp Gly Pro 
                85                  90                  95      

Gly Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln 
    

<210>   89
<211>   372
<212>   DNA
<213>   Homo sapiens

<400>   89
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt taccttttct tcttatgtta tgaattgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcttt atctctggtg attctagcaa tacctattat  180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat  240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactttt  300
atgcatggtc atcttggtgg tggtctttct atggattttt ggggccaagg caccctggtg  360
acggttagct ca                                                      372

<210>   90
<211>   351
<212>   DNA
<213>   Homo sapiens

<400>   90
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcaat atcaattatg atggtagctc tacctattat  180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat  240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatact  300
tatcttcatt ttgattattg gggccaaggc accctggtga cggttagctc a           351

<210>   91
<211>   372
<212>   DNA
<213>   Homo sapiens

<400>   91
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt taccttttct tcttatgtta tgaattgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcttt atctctggtg attctagcaa tacctattat  180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat  240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactttt  300
atgcatggtc atcttggtgg tggtctttct atggattttt ggggccaagg caccctggtg  360
acggttagct ca                                                      372

<210>   92
<211>   351
<212>   DNA
<213>   Homo sapiens

<400>   92
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcaat atcaattatg atggtagctc tacctattat  180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat  240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatact  300
tatcttcatt ttgattattg gggccaaggc accctggtga cggttagctc a           351

<210>   93
<211>   348
<212>   DNA
<213>   Homo sapiens

<400>   93
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcgtt actggtgttc atggtgatac ttattatgct  180
gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg  240
caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tgatacttat  300
cttcattttg attattgggg ccaaggcacc ctggtgacgg ttagctca               348

<210>   94
<211>   348
<212>   DNA
<213>   Homo sapiens

<400>   94
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcgtt attggtaatt ggggtgatac ttattatgct  180
gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg  240
caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tgatacttat  300
cttcattttg attattgggg ccaaggcacc ctggtgacgg ttagctca               348

<210>   95
<211>   348
<212>   DNA
<213>   Homo sapiens

<400>   95
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcgtt actactcatc agggttatac ttattatgct  180
gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg  240
caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tgatacttat  300
cttcattttg attattgggg ccaaggcacc ctggtgacgg ttagctca               348

<210>   96
<211>   348
<212>   DNA
<213>   Homo sapiens

<400>   96
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcgct actaatcgtt atggttatac ttattatgct  180
gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg  240
caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tgatacttat  300
cttcattttg attattgggg ccaaggcacc ctggtgacgg ttagctca               348

<210>   97
<211>   351
<212>   DNA
<213>   Homo sapiens

<400>   97
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcaat atcaattatg atggtagctc tacctattat  180
gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat  240
ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatact  300
tatcttcatt ttgattattg gggccaaggc accctggtga cggttagctc a           351

<210>   98
<211>   348
<212>   DNA
<213>   Homo sapiens

<400>   98
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcgtt attactcctt atggtgatac ttattatgct  180
gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg  240
caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tgatacttat  300
cttcattttg attattgggg ccaaggcacc ctggtgacgg ttagctca               348

<210>   99
<211>   348
<212>   DNA
<213>   Homo sapiens

<400>   99
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg  60
agctgcgcgg cctccggatt tacctttcgt tctcattggc tttcttgggt gcgccaagcc  120
cctgggaagg gtctcgagtg ggtgagcgtt attactcctt atggtgatac ttattatgct  180
gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg  240
caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg tgatacttat  300
cttcattttg attattgggg ccaaggcacc ctggtgacgg ttagctca               348

<210>   100
<211>   330
<212>   DNA
<213>   Homo sapiens

<400>   100
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc  60
tcgtgtagcg gcgataatat tggttctttt tatgttcatt ggtaccagca gaaacccggg  120
caggcgccag ttcttgtgat ttatgatgat aataatcgtc cctcaggcat cccggaacgc  180
tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa  240
gacgaagcgg attattattg cggttcttgg gctggttctt ctggttctta tgtgtttggc  300
ggccgcacga agttaaccgt tcttggccag                                   330

<210>   101
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   101
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tcttcttatg gtgagtctct tacttcttat  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   102
<211>   330
<212>   DNA
<213>   Homo sapiens

<400>   102
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc  60
tcgtgtagcg gcgataatat tggttctttt tatgttcatt ggtaccagca gaaacccggg  120
caggcgccag ttcttgtgat ttatgatgat aataatcgtc cctcaggcat cccggaacgc  180
tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa  240
gacgaagcgg attattattg cgcttcttgg actggtgttg agcctgatta tgtgtttggc  300
ggcggcacga agttaaccgt tcttggccag                                   330

<210>   103
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   103
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc cagtcttatg ctggttctta tctttctgag  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   104
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   104
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tcttcttatg gtgagtctct tacttcttat  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   105
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   105
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tcttcttatg gtgagtctct tacttcttat  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   106
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   106
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tcttcttatg gtgagtctct tacttcttat  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   107
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   107
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tcttcttatg gtgagtctct tacttcttat  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   108
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   108
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tctacttatg atggtcctgg tctttctgag  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   109
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   109
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tcttcttatg gtgagtctct tacttcttat  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   110
<211>   339
<212>   DNA
<213>   Homo sapiens

<400>   110
gatatcgcac tgacccagcc agcttcagtg agcggctcac caggtcagag cattaccatc  60
tcgtgtacgg gtactagcag cgatgttggt gatattaatg atgtgtcttg gtaccagcag  120
catcccggga aggcgccgaa acttatgatt tatgatgtta ataatcgtcc ctcaggcgtg  180
agcaaccgtt ttagcggatc caaaagcggc aacaccgcga gcctgaccat tagcggcctg  240
caagcggaag acgaagcgga ttattattgc tctacttatg atggtcctgg tctttctgag  300
gtgtttggcg gcggcacgaa gttaaccgtt cttggccag                         339

<210>   111
<211>   469
<212>   PRT
<213>   Homo sapiens

<400>   111
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Ser Ser Tyr Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Phe Ile Ser Gly Asp Ser Ser Asn Thr Tyr Tyr Ala 
65                  70                  75                  80  

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Thr Phe Met His Gly His Leu Gly Gly Gly Leu 
        115                 120                 125             

Ser Met Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 

Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             

Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 

Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 

Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     

Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             

Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 

Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         

Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             

Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     

Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 

Leu Ser Pro Gly Lys 
465                 

<210>   112
<211>   462
<212>   PRT
<213>   Homo sapiens

<400>   112
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 

Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
145                 150                 155                 160 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             

Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
    210                 215                 220                 

Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
225                 230                 235                 240 

Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
                245                 250                 255     

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             

Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 

Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
305                 310                 315                 320 

Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     

Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         

Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
                405                 410                 415     

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         

<210>   113
<211>   469
<212>   PRT
<213>   Homo sapiens

<400>   113
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Ser Ser Tyr Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Phe Ile Ser Gly Asp Ser Ser Asn Thr Tyr Tyr Ala 
65                  70                  75                  80  

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Thr Phe Met His Gly His Leu Gly Gly Gly Leu 
        115                 120                 125             

Ser Met Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
145                 150                 155                 160 

Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             

Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
    210                 215                 220                 

Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
225                 230                 235                 240 

Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
                245                 250                 255     

Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             

Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
305                 310                 315                 320 

Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
                325                 330                 335     

Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
            340                 345                 350         

Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             

Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 

Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     

Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 

Leu Ser Pro Gly Lys 
465                 

<210>   114
<211>   462
<212>   PRT
<213>   Homo sapiens

<400>   114
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 

Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
145                 150                 155                 160 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             

Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
    210                 215                 220                 

Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
225                 230                 235                 240 

Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
                245                 250                 255     

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             

Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 

Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
305                 310                 315                 320 

Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     

Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         

Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
                405                 410                 415     

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         

<210>   115
<211>   461
<212>   PRT
<213>   Homo sapiens

<400>   115
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Val Thr Gly Val His Gly Asp Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         

Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
145                 150                 155                 160 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    210                 215                 220                 

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
225                 230                 235                 240 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                245                 250                 255     

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        275                 280                 285             

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
305                 310                 315                 320 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                405                 410                 415     

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     

<210>   116
<211>   461
<212>   PRT
<213>   Homo sapiens

<400>   116
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Val Ile Gly Asn Trp Gly Asp Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         

Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
145                 150                 155                 160 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    210                 215                 220                 

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
225                 230                 235                 240 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                245                 250                 255     

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        275                 280                 285             

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
305                 310                 315                 320 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                405                 410                 415     

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     

<210>   117
<211>   461
<212>   PRT
<213>   Homo sapiens

<400>   117
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Val Thr Thr His Gln Gly Tyr Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         

Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
145                 150                 155                 160 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    210                 215                 220                 

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
225                 230                 235                 240 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                245                 250                 255     

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        275                 280                 285             

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
305                 310                 315                 320 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                405                 410                 415     

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     

<210>   118
<211>   465
<212>   PRT
<213>   Homo sapiens

<400>   118
Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      

Val Leu Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Ala Thr Asn Arg Tyr Gly Tyr Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         

Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             

Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 

Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 

Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
                165                 170                 175     

Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         

Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
        195                 200                 205             

Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 

Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
225                 230                 235                 240 

Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
                245                 250                 255     

Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
            260                 265                 270         

Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
        275                 280                 285             

Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
    290                 295                 300                 

Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
305                 310                 315                 320 

Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
                325                 330                 335     

Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
            340                 345                 350         

Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
        355                 360                 365             

Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
    370                 375                 380                 

Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
385                 390                 395                 400 

Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
                405                 410                 415     

Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
            420                 425                 430         

Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
        435                 440                 445             

Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
    450                 455                 460                 

Lys 
465 

<210>   119
<211>   462
<212>   PRT
<213>   Homo sapiens

<400>   119
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala 
65                  70                  75                  80  

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 

Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
145                 150                 155                 160 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             

Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
    210                 215                 220                 

Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
225                 230                 235                 240 

Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
                245                 250                 255     

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             

Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 

Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
305                 310                 315                 320 

Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     

Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         

Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             

Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
                405                 410                 415     

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         

<210>   120
<211>   461
<212>   PRT
<213>   Homo sapiens

<400>   120
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Val Ile Thr Pro Tyr Gly Asp Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         

Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
145                 150                 155                 160 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    210                 215                 220                 

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
225                 230                 235                 240 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                245                 250                 255     

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        275                 280                 285             

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
305                 310                 315                 320 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                405                 410                 415     

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     

<210>   121
<211>   461
<212>   PRT
<213>   Homo sapiens

<400>   121
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      

Val Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              

Arg Ser His Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Val Ser Val Ile Thr Pro Tyr Gly Asp Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  

Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         

Tyr Cys Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
145                 150                 155                 160 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
    210                 215                 220                 

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
225                 230                 235                 240 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                245                 250                 255     

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        275                 280                 285             

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
305                 310                 315                 320 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                405                 410                 415     

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     

<210>   122
<211>   130
<212>   PRT
<213>   Homo sapiens

<400>   122
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          

Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly 
        35                  40                  45              

Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  

Leu Val Ile Tyr Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  

Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
                85                  90                  95      

Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Trp Ala Gly 
            100                 105                 110         

Ser Ser Gly Ser Tyr Val Phe Gly Gly Arg Thr Lys Leu Thr Val Leu 
        115                 120                 125             

Gly Gln 
    130 

<210>   123
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   123
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         

Tyr Gly Glu Ser Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   124
<211>   234
<212>   PRT
<213>   Homo sapiens

<400>   124
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          

Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly 
        35                  40                  45              

Ser Phe Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
    50                  55                  60                  

Leu Val Ile Tyr Asp Asp Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  

Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
                85                  90                  95      

Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Thr Gly 
            100                 105                 110         

Val Glu Pro Asp Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 

Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 

Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     

Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         

Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             

Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 

Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 

<210>   125
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   125
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
            100                 105                 110         

Tyr Ala Gly Ser Tyr Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   126
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   126
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         

Tyr Gly Glu Ser Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   127
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   127
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         

Tyr Gly Glu Ser Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   128
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   128
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         

Tyr Gly Glu Ser Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   129
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   129
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         

Tyr Gly Glu Ser Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   130
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   130
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr 
            100                 105                 110         

Tyr Asp Gly Pro Gly Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   131
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   131
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser 
            100                 105                 110         

Tyr Gly Glu Ser Leu Thr Ser Tyr Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   132
<211>   237
<212>   PRT
<213>   Homo sapiens

<400>   132
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      

Gly Thr Arg Cys Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          

Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp 
        35                  40                  45              

Val Gly Asp Ile Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  

Ala Pro Lys Leu Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  

Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      

Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr 
            100                 105                 110         

Tyr Asp Gly Pro Gly Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
    130                 135                 140                 

Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 

Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
                165                 170                 175     

Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
            180                 185                 190         

Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
        195                 200                 205             

Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
    210                 215                 220                 

Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235         

<210>   133
<211>   1410
<212>   DNA
<213>   Homo sapiens

<400>   133
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagcgt gcaggcccag  60
gtgcagctgg tcgagtctgg cggcggactg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagcagc tacgtgatga actgggtgcg gcaggcccct  180
ggcaagggcc tggagtgggt gtccttcatc agcggcgaca gcagcaacac ctactacgcc  240
gacagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg  300
cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgcccg gaccttcatg  360
cacggccacc tgggcggagg actgagcatg gatttctggg gccagggcac cctggtcacc  420
gtctcctcag cttccaccaa gggcccatcc gtcttccccc tggcgccctg ctccaggagc  480
acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg  540
acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta  600
cagtcctcag gactctactc cctcagcagc gtggtgacag tgccctccag caacttcggc  660
acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca  720
gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag caccacctgt ggcaggaccg  780
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag  840
gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac  900
gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc  960
acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag  1020
tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa  1080
accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg  1140
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc  1200
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg  1260
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag  1320
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag  1380
aagagcctct ccctgtctcc gggtaaatga                                   1410

<210>   134
<211>   1389
<212>   DNA
<213>   Homo sapiens

<400>   134
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaggtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccaacatc aactacgacg gcagcagcac ctactacgcc  240
gacagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg  300
cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag ggacacctac  360
ctgcacttcg actactgggg ccagggcacc ctggtcaccg tctcctcagc ttccaccaag  420
ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagcggcc  480
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc  540
gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg actctactcc  600
ctcagcagcg tggtgacagt gccctccagc aacttcggca cccagaccta cacctgcaac  660
gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc  720
gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca  780
aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac  840
gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt ggaggtgcat  900
aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc  960
ctcaccgttg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac  1020
aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa  1080
ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg  1140
acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg  1200
cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc  1260
ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc  1320
tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg  1380
ggtaaatga                                                          1389

<210>   135
<211>   1410
<212>   DNA
<213>   Homo sapiens

<400>   135
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagcgt gcaggcccag  60
gtgcagctgg tcgagtctgg cggcggactg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagcagc tacgtgatga actgggtgcg gcaggcccct  180
ggcaagggcc tggagtgggt gtccttcatc agcggcgaca gcagcaacac ctactacgcc  240
gacagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg  300
cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgcccg gaccttcatg  360
cacggccacc tgggcggagg actgagcatg gatttctggg gccagggcac cctggtcacc  420
gtctcctcag cttccaccaa gggcccatcc gtcttccccc tggcgccctg ctccaggagc  480
acctccgaga gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg  540
acggtgtcgt ggaactcagg cgctctgacc agcggcgtgc acaccttccc agctgtccta  600
cagtcctcag gactctactc cctcagcagc gtggtgacag tgccctccag caacttcggc  660
acccagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaca  720
gttgagcgca aatgttgtgt cgagtgccca ccgtgcccag caccacctgt ggcaggaccg  780
tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag  840
gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg aggtccagtt caactggtac  900
gtggacggcg tggaggtgca taatgccaag acaaagccac gggaggagca gttcaacagc  960
acgttccgtg tggtcagcgt cctcaccgtt gtgcaccagg actggctgaa cggcaaggag  1020
tacaagtgca aggtctccaa caaaggcctc ccagccccca tcgagaaaac catctccaaa  1080
accaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg  1140
accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc  1200
gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacacc tcccatgctg  1260
gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag  1320
caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag  1380
aagagcctct ccctgtctcc gggtaaatga                                   1410

<210>   136
<211>   1389
<212>   DNA
<213>   Homo sapiens

<400>   136
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaggtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccaacatc aactacgacg gcagcagcac ctactacgcc  240
gacagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg  300
cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag ggacacctac  360
ctgcacttcg actactgggg ccagggcacc ctggtcaccg tctcctcagc ttccaccaag  420
ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagcggcc  480
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc  540
gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg actctactcc  600
ctcagcagcg tggtgacagt gccctccagc aacttcggca cccagaccta cacctgcaac  660
gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc  720
gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca  780
aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac  840
gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt ggaggtgcat  900
aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc  960
ctcaccgttg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac  1020
aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa  1080
ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg  1140
acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg  1200
cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc  1260
ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc  1320
tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg  1380
ggtaaatga                                                          1389

<210>   137
<211>   1386
<212>   DNA
<213>   Homo sapiens

<400>   137
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccgtgacc ggcgtgcacg gcgacaccta ctacgccgac  240
agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag  300
atgaacagcc tgcgggccga ggacaccgcc gtgtactact gcgccaggga cacctacctg  360
cacttcgact actggggcca gggcaccctg gtcaccgtct cctcagcttc caccaagggc  420
ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg  480
ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct  540
ctgaccagcg gcgtgcacac cttcccagct gtcctacagt cctcaggact ctactccctc  600
agcagcgtgg tgacagtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta  660
gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag  720
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa  780
cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg  840
agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat  900
gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc  960
accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa  1020
ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca  1080
caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc  1140
tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag  1200
ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc  1260
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc  1320
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt  1380
aaatga                                                             1386

<210>   138
<211>   1386
<212>   DNA
<213>   Homo sapiens

<400>   138
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccgtgatc ggcaactggg gcgacaccta ctacgccgac  240
agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag  300
atgaacagcc tgcgggccga ggacaccgcc gtgtactact gcgccaggga cacctacctg  360
cacttcgact actggggcca gggcaccctg gtcaccgtct cctcagcttc caccaagggc  420
ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg  480
ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct  540
ctgaccagcg gcgtgcacac cttcccagct gtcctacagt cctcaggact ctactccctc  600
agcagcgtgg tgacagtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta  660
gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag  720
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa  780
cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg  840
agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat  900
gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc  960
accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa  1020
ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca  1080
caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc  1140
tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag  1200
ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc  1260
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc  1320
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt  1380
aaatga                                                             1386

<210>   139
<211>   1386
<212>   DNA
<213>   Homo sapiens

<400>   139
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccgtgacc acccaccagg gctacaccta ctacgccgac  240
agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag  300
atgaacagcc tgcgggccga ggacaccgcc gtgtactact gcgccaggga cacctacctg  360
cacttcgact actggggcca gggcaccctg gtcaccgtct cctcagcttc caccaagggc  420
ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg  480
ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct  540
ctgaccagcg gcgtgcacac cttcccagct gtcctacagt cctcaggact ctactccctc  600
agcagcgtgg tgacagtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta  660
gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag  720
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa  780
cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg  840
agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat  900
gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc  960
accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa  1020
ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca  1080
caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc  1140
tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag  1200
ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc  1260
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc  1320
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt  1380
aaatga                                                             1386

<210>   140
<211>   1386
<212>   DNA
<213>   Homo sapiens

<400>   140
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccgccacc aacagatacg gctacaccta ctacgccgac  240
agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag  300
atgaacagcc tgcgggccga ggacaccgcc gtgtactact gcgccaggga cacctacctg  360
cacttcgact actggggcca gggcaccctg gtcaccgtct cctcagcttc caccaagggc  420
ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg  480
ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct  540
ctgaccagcg gcgtgcacac cttcccagct gtcctacagt cctcaggact ctactccctc  600
agcagcgtgg tgacagtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta  660
gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag  720
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa  780
cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg  840
agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat  900
gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc  960
accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa  1020
ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca  1080
caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc  1140
tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag  1200
ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc  1260
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc  1320
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt  1380
aaatga                                                             1386

<210>   141
<211>   1389
<212>   DNA
<213>   Homo sapiens

<400>   141
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaggtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccaacatc aactacgacg gcagcagcac ctactacgcc  240
gacagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg  300
cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag ggacacctac  360
ctgcacttcg actactgggg ccagggcacc ctggtcaccg tctcctcagc ttccaccaag  420
ggcccatccg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagcggcc  480
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc  540
gctctgacca gcggcgtgca caccttccca gctgtcctac agtcctcagg actctactcc  600
ctcagcagcg tggtgacagt gccctccagc aacttcggca cccagaccta cacctgcaac  660
gtagatcaca agcccagcaa caccaaggtg gacaagacag ttgagcgcaa atgttgtgtc  720
gagtgcccac cgtgcccagc accacctgtg gcaggaccgt cagtcttcct cttcccccca  780
aaacccaagg acaccctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac  840
gtgagccacg aagaccccga ggtccagttc aactggtacg tggacggcgt ggaggtgcat  900
aatgccaaga caaagccacg ggaggagcag ttcaacagca cgttccgtgt ggtcagcgtc  960
ctcaccgttg tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac  1020
aaaggcctcc cagcccccat cgagaaaacc atctccaaaa ccaaagggca gccccgagaa  1080
ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg  1140
acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg  1200
cagccggaga acaactacaa gaccacacct cccatgctgg actccgacgg ctccttcttc  1260
ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc  1320
tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg  1380
ggtaaatga                                                          1389

<210>   142
<211>   1386
<212>   DNA
<213>   Homo sapiens

<400>   142
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccgtgatc accccctacg gcgacaccta ctacgccgac  240
agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag  300
atgaacagcc tgcgggccga ggacaccgcc gtgtactact gcgccaggga cacctacctg  360
cacttcgact actggggcca gggcaccctg gtcaccgtct cctcagcttc caccaagggc  420
ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg  480
ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct  540
ctgaccagcg gcgtgcacac cttcccagct gtcctacagt cctcaggact ctactccctc  600
agcagcgtgg tgacagtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta  660
gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag  720
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa  780
cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg  840
agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat  900
gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc  960
accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa  1020
ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca  1080
caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc  1140
tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag  1200
ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc  1260
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc  1320
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt  1380
aaatga                                                             1386

<210>   143
<211>   1386
<212>   DNA
<213>   Homo sapiens

<400>   143
atggcttggg tgtggacctt gccattcctg atggcagctg cccaaagtgt ccaggcccag  60
gtgcagctgg tcgagagcgg cggagggctg gtgcagcctg gcggcagcct gagactgagc  120
tgcgccgcca gcggcttcac cttcagaagc cactggctgt cctgggtgcg gcaggcccct  180
ggcaagggcc tggaatgggt gtccgtgatc accccctacg gcgacaccta ctacgccgac  240
agcgtgaagg gccggttcac catcagccgg gacaacagca agaacaccct gtacctgcag  300
atgaacagcc tgcgggccga ggacaccgcc gtgtactact gcgccaggga cacctacctg  360
cacttcgact actggggcca gggcaccctg gtcaccgtct cctcagcttc caccaagggc  420
ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agcggccctg  480
ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgct  540
ctgaccagcg gcgtgcacac cttcccagct gtcctacagt cctcaggact ctactccctc  600
agcagcgtgg tgacagtgcc ctccagcaac ttcggcaccc agacctacac ctgcaacgta  660
gatcacaagc ccagcaacac caaggtggac aagacagttg agcgcaaatg ttgtgtcgag  720
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa  780
cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg  840
agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat  900
gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc  960
accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa  1020
ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca  1080
caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc  1140
tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag  1200
ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc  1260
tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc  1320
gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt  1380
aaatga                                                             1386

<210>   144
<211>   393
<212>   DNA
<213>   Homo sapiens

<400>   144
atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac cgtagcgcag  60
gccgatatcg aactgaccca gccgccttca gtgagcgttg caccaggtca gaccgcgcgt  120
atctcgtgta gcggcgataa tattggttct ttttatgttc attggtacca gcagaaaccc  180
gggcaggcgc cagttcttgt gatttatgat gataataatc gtccctcagg catcccggaa  240
cgctttagcg gatccaacag cggcaacacc gcgaccctga ccattagcgg cactcaggcg  300
gaagacgaag cggattatta ttgcggttct tgggctggtt cttctggttc ttatgtgttt  360
ggcggccgca cgaagttaac cgttcttggc cag                               393

<210>   145
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   145
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcagctacg gcgagagcct gaccagctac  360
gtgtttggcg gcggaaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   146
<211>   705
<212>   DNA
<213>   Homo sapiens

<400>   146
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgagc tgacccagcc ccccagcgtg agcgtggccc ctggccagac cgcccggatc  120
agctgcagcg gcgacaacat cggcagcttc tacgtgcact ggtatcagca gaagcccggc  180
caggcccccg tgctggtgat ctacgacgac aacaaccggc ccagcggcat ccccgagcgg  240
ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccgag  300
gacgaggccg actactactg cgccagctgg accggcgtgg agcccgacta cgtgtttggc  360
ggcggaacaa agcttaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc  420
ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac  480
ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga  540
gtggagacaa ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg  600
agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa  660
gggagcaccg tggaaaagac agtggcccct acagaatgtt catag                  705

<210>   147
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   147
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc cagagctacg ccggcagcta cctgagcgag  360
gtgttcggcg gagggaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   148
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   148
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcagctacg gcgagagcct gaccagctac  360
gtgtttggcg gcggaaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   149
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   149
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcagctacg gcgagagcct gaccagctac  360
gtgtttggcg gcggaaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   150
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   150
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcagctacg gcgagagcct gaccagctac  360
gtgtttggcg gcggaaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   151
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   151
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcagctacg gcgagagcct gaccagctac  360
gtgtttggcg gcggaaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   152
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   152
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcacctacg acggccctgg cctgagcgag  360
gtgttcggcg gagggaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   153
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   153
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcacctacg acggccctgg cctgagcgag  360
gtgttcggcg gagggaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   154
<211>   714
<212>   DNA
<213>   Homo sapiens

<400>   154
atgagtgtgc tcactcaggt cctggcgttg ctgctgctgt ggcttacagg tacgcgttgc  60
gacatcgccc tgacccagcc cgccagcgtg agcggcagcc ctggccagag catcaccatc  120
agctgcaccg gcaccagcag cgacgtgggc gacatcaacg acgtgagctg gtatcagcag  180
caccccggca aggcccccaa gctgatgatc tacgacgtga acaaccggcc cagcggcgtg  240
agcaaccggt tcagcggcag caagagcggc aacaccgcca gcctgaccat cagcggcctc  300
caggccgagg acgaggccga ctactactgc agcacctacg acggccctgg cctgagcgag  360
gtgttcggcg gagggaccaa gcttaccgtc ctaggtcagc ccaaggctgc cccctcggtc  420
actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc  480
ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc  540
aaggcgggag tggagacaac cacaccctcc aaacaaagca acaacaagta cgcggccagc  600
agctatctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc  660
acgcatgaag ggagcaccgt ggaaaagaca gtggccccta cagaatgttc atag        714

<210>   155
<211>   213
<212>   PRT
<213>   Homo sapiens

<400>   155
Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr 
1               5                   10                  15      

Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp 
            20                  25                  30          

Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro 
        35                  40                  45              

Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg 
    50                  55                  60                  

Pro Pro His His Pro Phe Glu Thr Lys Asp Val Ser Glu Tyr Ser Cys 
65                  70                  75                  80  

Arg Glu Leu His Phe Thr Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser 
                85                  90                  95      

Ala Lys Pro Val Thr Glu Leu Val Cys Ser Gly Gln Cys Gly Pro Ala 
            100                 105                 110         

Arg Leu Leu Pro Asn Ala Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser 
        115                 120                 125             

Gly Pro Asp Phe Arg Cys Ile Pro Asp Arg Tyr Arg Ala Gln Arg Val 
    130                 135                 140                 

Gln Leu Leu Cys Pro Gly Gly Glu Ala Pro Arg Ala Arg Lys Val Arg 
145                 150                 155                 160 

Leu Val Ala Ser Cys Lys Cys Lys Arg Leu Thr Arg Phe His Asn Gln 
                165                 170                 175     

Ser Glu Leu Lys Asp Phe Gly Thr Glu Ala Ala Arg Pro Gln Lys Gly 
            180                 185                 190         

Arg Lys Pro Arg Pro Arg Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu 
        195                 200                 205             

Leu Glu Asn Ala Tyr 
    210             

<210>   156
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   156
Ala Arg Leu Leu Asn Ala Ile Gly Arg Gly Lys Trp Trp Arg 
1               5                   10                  

<210>   157
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   157
Arg Leu Val Ala Ser Cys Lys Cys Lys Arg Leu Thr Arg Phe His 
1               5                   10                  15  

<210>   158
<211>   13
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   158
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10              

<210>   159
<211>   19
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   159
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      

Gly Gly Gly 
            

<210>   160
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   160
taaattatca taaagtccta a                                            21

<210>   161
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   161
aggactttat gataatttat t                                            21

<210>   162
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   162
atagtggtta aataactcca g                                            21

<210>   163
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   163
ggagttattt aaccactatt t                                            21

<210>   164
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   164
taaattctcg tgatgtgcca t                                            21

<210>   165
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   165
ggcacatcac gagaatttat t                                            21

<210>   166
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   166
tttcttatag cacagctggt t                                            21

<210>   167
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   167
ccagctgtgc tataagaaat t                                            21

<210>   168
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   168
tagacctttc catccacgct g                                            21

<210>   169
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   169
gcgtggatgg aaaggtctat t                                            21

<210>   170
<211>   29
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   170
atgcagctcc cactggccct gtgtcttgt                                    29

<210>   171
<211>   30
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Artificial sequence 

<400>   171
aatcaggccg agctggagaa cgcctactag                                   30

<210>   172
<211>   443
<212>   PRT
<213>   Homo sapiens

<400>   172
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser His 
            20                  25                  30          

Trp Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              

Ser Asn Ile Asn Tyr Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Asp Thr Tyr Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         

Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             

Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 

Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 

Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     

Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         

Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
    210                 215                 220                 

Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             

Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 

Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 

Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         

Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 

Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             

<210>   173
<211>   217
<212>   PRT
<213>   Artificial Sequence

<220>
<223>   Homo sapiens

<400>   173
Asp Ile Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Asp Ile 
            20                  25                  30          

Asn Asp Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              

Met Ile Tyr Asp Val Asn Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Ala Gly Ser 
                85                  90                  95      

Tyr Leu Ser Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             

Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 

Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 

Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     

Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         

His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             

Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         

<210>   174
<211>   26
<212>   PRT
<213>   Homo sapiens

<400>   174
Cys Gly Pro Ala Arg Leu Leu Pro Asn Ala Ile Gly Arg Gly Lys Trp 
1               5                   10                  15      

Trp Arg Pro Ser Gly Pro Asp Phe Arg Cys 
            20                  25      

<210>   175
<211>   60
<212>   PRT
<213>   Homo sapiens

<400>   175
Asp Val Ser Glu Tyr Cys Arg Glu Leu His Phe Thr Arg Ser Ala Lys 
1               5                   10                  15      

Pro Val Thr Glu Leu Val Cys Ser Gly Gln Cys Gly Pro Ala Arg Trp 
            20                  25                  30          

Trp Arg Pro Ser Gly Pro Asp Phe Arg Cys Ile Pro Asp Arg Tyr Arg 
        35                  40                  45              

Leu Val Ala Ser Cys Lys Cys Lys Arg Leu Thr Arg 
    50                  55                  60  

<210>  176
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Humanized Antibody Sequence

<400>  176

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asp Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Ala Tyr Asn Asp Val Ile Tyr Ala Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg 
    130             

<210>  177
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Humanized Antibody Sequence

<400>  177

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val His Cys Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Thr Ile Asp Ser Gly Gly Arg Thr Asp Tyr Ala Ser 
65                  70                  75                  80  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Met Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Arg Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asn Trp Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     





