                         SEQUENCE LISTING

<110>  LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC
 
<120>  SULFITE TOLERANCE IN RECOMBINANT YEAST HOST CELLS

<130>  N412631WO

<150>  62/438,391 
<151>  2016-12-22

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  299
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Thr Asp Ile Gly Arg Thr Lys Ser Arg Asn Tyr Lys Cys Ser Phe 
1               5                   10                  15      


Asp Gly Cys Glu Lys Val Tyr Asn Arg Pro Ser Leu Leu Gln Gln His 
            20                  25                  30          


Gln Asn Ser His Thr Asn Gln Lys Pro Tyr His Cys Asp Glu Pro Gly 
        35                  40                  45              


Cys Gly Lys Lys Phe Ile Arg Pro Cys His Leu Arg Val His Lys Trp 
    50                  55                  60                  


Thr His Ser Gln Ile Lys Pro Lys Ala Cys Thr Leu Cys Gln Lys Arg 
65                  70                  75                  80  


Phe Val Thr Asn Gln Gln Leu Arg Arg His Leu Asn Ser His Glu Arg 
                85                  90                  95      


Lys Ser Lys Leu Ala Ser Arg Ile Asp Arg Lys His Glu Gly Val Asn 
            100                 105                 110         


Ala Asn Val Lys Ala Glu Leu Asn Gly Lys Glu Gly Gly Phe Asp Pro 
        115                 120                 125             


Lys Leu Pro Ser Gly Ser Pro Met Cys Gly Glu Glu Phe Ser Gln Gly 
    130                 135                 140                 


His Leu Pro Gly Tyr Asp Asp Met Gln Val Leu Gln Cys Pro Tyr Lys 
145                 150                 155                 160 


Ser Cys Gln Lys Val Thr Ser Phe Asn Asp Asp Leu Ile Asn His Met 
                165                 170                 175     


Leu Gln His His Ile Ala Ser Lys Leu Val Val Pro Ser Gly Asp Pro 
            180                 185                 190         


Ser Leu Lys Glu Ser Leu Pro Thr Ser Glu Lys Ser Ser Ser Thr Asp 
        195                 200                 205             


Thr Thr Ser Ile Pro Gln Leu Ser Phe Ser Thr Thr Gly Thr Ser Ser 
    210                 215                 220                 


Ser Glu Ser Val Asp Ser Thr Thr Ala Gln Thr Pro Thr Asp Pro Glu 
225                 230                 235                 240 


Ser Tyr Trp Ser Asp Asn Arg Cys Lys His Ser Asp Cys Gln Glu Leu 
                245                 250                 255     


Ser Pro Phe Ala Ser Val Phe Asp Leu Ile Asp His Tyr Asp His Thr 
            260                 265                 270         


His Ala Phe Ile Pro Glu Thr Leu Val Lys Tyr Ser Tyr Ile His Leu 
        275                 280                 285             


Tyr Lys Pro Ser Val Trp Asp Leu Phe Glu Tyr 
    290                 295                 


<210>  2
<211>  311
<212>  PRT
<213>  Saccharomyces paradoxus

<400>  2

Met Val Ala Ala Arg Val Asp Phe Gly Ile Gly Gly Met Thr Asn Thr 
1               5                   10                  15      


Gly Lys Pro Lys Ser Arg Cys Tyr Lys Cys Pro Phe Asn Gly Cys Glu 
            20                  25                  30          


Lys Glu Tyr Asn Arg Pro Ser Leu Leu Gln Arg His Leu Asn Ser His 
        35                  40                  45              


Thr Asn Gln Arg Pro Tyr Pro Cys Asp Glu Pro Gly Cys Gly Lys Lys 
    50                  55                  60                  


Phe Ile Arg Pro Cys His Leu Arg Val His Lys Trp Thr His Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Lys Pro Cys Thr Leu Cys Lys Lys Arg Phe Val Thr Asn 
                85                  90                  95      


Gln Gln Leu Lys Arg His Leu Asn Ser His Lys Arg Lys Asn Arg Val 
            100                 105                 110         


Ala Ser Lys Asn Asn Tyr Lys His Glu Gly Pro Cys Ser Asn Ile Lys 
        115                 120                 125             


Ala Glu Leu Ser Gly Val Asp Gly Gly Leu Asp Pro Ala Leu Thr Ser 
    130                 135                 140                 


Gly Ser Val Met Tyr Asp Glu Glu Ser Leu Gln Gly His Leu Pro Gly 
145                 150                 155                 160 


Ser Asp Asp Met Arg Val Leu Gln Cys Pro Tyr Lys Ser Cys Gln Lys 
                165                 170                 175     


Val Thr Ser Phe Asn Asp Asp Leu Ile Asn His Met Leu Gln His His 
            180                 185                 190         


Ile Ala Ser Lys Leu Val Val Pro Ser Glu Glu Ser Arg Leu Lys Lys 
        195                 200                 205             


Ser Thr Pro Thr Ser Val Glu Ser Ser Ser Thr Asp Ile Thr Ser Ile 
    210                 215                 220                 


Pro Gln Leu Ser Leu Ser Thr Thr Gly Thr Ser Ser Ser Asp Ser Ser 
225                 230                 235                 240 


Asn Glu Thr Met Ala Arg Ser Pro Asn Asp Pro Glu Asn Tyr Trp Ser 
                245                 250                 255     


Asp Asn Arg Cys Lys Gln Thr Glu Cys Gln Glu Leu Ser Pro Phe Ala 
            260                 265                 270         


Ser Val Phe Asp Leu Ile Glu His Tyr Asp Arg Thr His Ala Phe Ile 
        275                 280                 285             


Pro Glu Thr Leu Val Lys Tyr Ser Tyr Ile Phe Leu Tyr Lys Pro Ser 
    290                 295                 300                 


Val Arg Gly Leu Phe Glu Tyr 
305                 310     


<210>  3
<211>  310
<212>  PRT
<213>  Saccharomyces mikatea

<400>  3

Met Ala Ala Arg Thr Asp Ser Gly Val Gly Thr Met Thr Asn Arg Glu 
1               5                   10                  15      


Arg Ser Lys Ser Arg Lys Tyr Lys Cys Pro Phe Asp Ser Cys Glu Lys 
            20                  25                  30          


Glu Tyr Asn Arg Pro Ser Leu Leu Gln Gln His Gln Asn Ser His Thr 
        35                  40                  45              


Asn Arg Lys Pro Tyr His Cys Asp Glu Pro Gly Cys Gly Lys Lys Phe 
    50                  55                  60                  


Ile Arg Pro Cys His Leu Arg Val His Lys Trp Thr His Ser Gln Ile 
65                  70                  75                  80  


Lys Pro Lys Pro Cys Pro Leu Cys Glu Lys Arg Phe Val Thr Asn Gln 
                85                  90                  95      


Gln Leu Arg Arg His Leu Ser Ser His Glu Arg Lys Ser Lys Leu Ala 
            100                 105                 110         


Ser Ile Asn His Arg Arg His Glu Glu Pro Asp Pro Asn Thr Lys Ala 
        115                 120                 125             


Glu Leu Asn Asp Gly Glu Gly Ser Ile Asp Ser Ile Leu Ser Ser Gly 
    130                 135                 140                 


Ser Leu Ile His Gly Glu Glu Ser Ser Gln Gly His Leu Pro Gly Ser 
145                 150                 155                 160 


Asp Asp Met Pro Val Leu Gln Cys Pro Tyr Arg Ser Cys Gln Lys Ala 
                165                 170                 175     


Thr Ser Phe Asn Asp Asp Leu Ile Asn His Met Leu Gln Tyr His Ile 
            180                 185                 190         


Ser Ser Met Leu Val Val Pro Ser Glu Gly Pro His Leu Lys Lys Cys 
        195                 200                 205             


Thr Pro Asn Ser Ala Arg Ser Ser Asn Thr Asp Phe Thr Pro Ile Pro 
    210                 215                 220                 


Leu Leu Ser Pro Ser Thr Thr Ala Thr Thr Ser Ser Asp Ser Ser Lys 
225                 230                 235                 240 


Ser Ile Thr Met Gln Ser Pro Asp Asp Pro Glu Thr Tyr Trp Ser Asp 
                245                 250                 255     


Asn Gln Cys Lys His Ile Asp Cys Gln Glu Leu Ile Pro Phe Pro Ser 
            260                 265                 270         


Val Phe Asp Leu Ile Glu His Tyr Asp His Ile His Ala Phe Ile Pro 
        275                 280                 285             


Glu Thr Leu Val Lys Tyr Ser Tyr Ile His Leu Tyr Glu Pro Ser Val 
    290                 295                 300                 


Trp Gly Leu Phe Glu Tyr 
305                 310 


<210>  4
<211>  297
<212>  PRT
<213>  Saccharomyces uvarum

<400>  4

Met Ala Asn Lys Lys Lys Leu His Ser Arg Arg Tyr Lys Cys Ser Phe 
1               5                   10                  15      


Glu Gly Cys Gly Lys Asp Tyr Asn Arg Pro Ser Leu Leu Glu Gln His 
            20                  25                  30          


Glu Asn Ser His Phe Asn Gln Lys Pro Tyr Leu Cys Asp Glu Pro Gly 
        35                  40                  45              


Cys Gly Lys Lys Phe Ile Arg Pro Cys His Leu Arg Val His Lys Trp 
    50                  55                  60                  


Thr His Ser Gln Ile Lys Pro Lys Pro Cys Thr Leu Cys Glu Lys Arg 
65                  70                  75                  80  


Phe Val Thr Asn Gln Gln Leu Asn Arg His Leu Ser Ser His Glu Arg 
                85                  90                  95      


Lys Asp Lys Leu Lys Ser Lys Ile Ile Thr Lys Asn Glu Glu Pro Gly 
            100                 105                 110         


Pro Asn Ile Lys Ser Asp Tyr Gly Gly Asn Glu Leu Asn Leu Gly Thr 
        115                 120                 125             


Thr Leu Pro Asp Gln Leu Leu Pro Leu Asp Asp Asn Leu Pro Gln Asp 
    130                 135                 140                 


Tyr Leu Leu Arg Ala Asp Asp Met Asn Ala Val Arg Cys Pro Tyr Val 
145                 150                 155                 160 


Leu Cys Gln Val Leu Thr Thr Phe Asp Asp Asp Leu Ile Asn His Met 
                165                 170                 175     


Leu Gln His His Ile Ala Ser Lys Leu Thr Leu Pro Pro Glu Glu Leu 
            180                 185                 190         


His Leu Asn Asn Gln Ala Pro Val Ser Pro Cys Ser Ser Ser Thr Asp 
        195                 200                 205             


Asp Ala Ser Ile Pro Gln Leu Ser Ala Ala Ala Ser Ser Asp Ser Ser 
    210                 215                 220                 


Tyr Ser Thr Gly Thr Ile Val Glu Ser Leu Asp Asp Pro Glu Ser Tyr 
225                 230                 235                 240 


Trp Ser Asp His Arg Cys Lys His Ile His Cys Gln Glu Leu Asp Arg 
                245                 250                 255     


Phe Ala Ser Val Phe Asp Leu Ile Asp His Tyr Asp His Ala His Ala 
            260                 265                 270         


Tyr Ile Pro Glu Thr Leu Val Lys Tyr Ser Tyr Ile His Leu Tyr Lys 
        275                 280                 285             


Pro Asn Val Arg Ser Leu Phe Glu Tyr 
    290                 295         


<210>  5
<211>  296
<212>  PRT
<213>  Saccharomyces kudriazevi

<400>  5

Met Ala Asn Thr Lys Lys Pro Lys Ala Arg Ser Tyr Lys Cys Ser Leu 
1               5                   10                  15      


Glu Gly Cys Glu Lys Glu Tyr Asn Arg Pro Ser Leu Leu Gln Gln His 
            20                  25                  30          


Gln Asn Ser His Thr Asn Gln Lys Pro Tyr Arg Cys Asp Glu Pro Ser 
        35                  40                  45              


Cys Gly Lys Lys Phe Ile Arg Pro Cys His Leu Arg Val His Lys Trp 
    50                  55                  60                  


Thr His Ser Gln Ile Lys Pro Lys Pro Cys Pro Leu Cys Glu Lys Arg 
65                  70                  75                  80  


Phe Val Thr Asn Gln Gln Leu Lys Arg His Leu Gly Ser His Glu Arg 
                85                  90                  95      


Lys Asn Lys Leu Ala Ser Lys Ile Asn Asp Lys Asn Glu Glu Pro Asn 
            100                 105                 110         


Pro Gly Ile Ser Ala Asn Ser Lys Gly Ser Lys Ser Ser Leu Asp Pro 
        115                 120                 125             


Ser Leu Pro Pro Leu His Asp Glu Ala Leu Leu Gln Asp His Leu Pro 
    130                 135                 140                 


Gly Phe Asp Asp Met Gln Val Leu Gln Cys Pro Tyr Lys Ser Cys Gln 
145                 150                 155                 160 


Arg Val Thr Ser Phe Ser Asp Asp Leu Val Asn His Met Leu Gln Gln 
                165                 170                 175     


His Ile Thr Ser Lys Leu Thr Val Pro Tyr Glu Glu Leu Pro Leu Gly 
            180                 185                 190         


Lys Pro Leu Ser Ile Ser Ala Lys Ser Ser Ser Thr Asp Ile Thr Ser 
        195                 200                 205             


Ile Pro Gln Leu Ser Leu Ser Ile Asp Gly Thr Ser Ser Ser Asp Ser 
    210                 215                 220                 


Gly His Ser Thr Val Leu Gln Ser Pro Glu Asp Pro Glu Ser Tyr Trp 
225                 230                 235                 240 


Ser Asp Asn Arg Cys Lys His Thr Asp Cys Gln Asp Leu Ser Pro Leu 
                245                 250                 255     


Thr Ser Val Phe Asp Leu Ile Asp His Tyr Asp His Thr His Ala Phe 
            260                 265                 270         


Ile Pro Glu Thr Leu Val Lys Tyr Ser Tyr Ile His Leu Tyr Lys Pro 
        275                 280                 285             


Asn Val Trp Gly Leu Phe Glu Tyr 
    290                 295     


<210>  6
<211>  327
<212>  PRT
<213>  Saccharomyces castellii

<400>  6

Met Val Ala Thr Glu Lys Arg Ser Lys Lys Lys Val Tyr Lys Cys Gln 
1               5                   10                  15      


Phe Glu Gly Cys His Arg Glu Phe Thr Arg Pro Cys Leu Leu Gln Gln 
            20                  25                  30          


His Arg Tyr Ser His Thr Asn Glu Arg Pro Tyr Ile Cys Asp Val Glu 
        35                  40                  45              


Gly Cys Gly Lys Arg Phe Met Arg Pro Cys His Leu Lys Val His Lys 
    50                  55                  60                  


Trp Thr His Ser Lys Val Lys Pro Leu Lys Cys Ala Phe Cys Glu Lys 
65                  70                  75                  80  


Gly Phe Ile Thr Asn Gln Gln Leu Lys Arg His Leu Asn Thr His Ala 
                85                  90                  95      


Lys Lys Ser Arg Lys Ala Leu Leu Ala Ile Thr Pro Pro Asn Glu Ser 
            100                 105                 110         


Glu Thr Asn Glu Lys Lys Gln Gln Lys Lys Ala Asn Ser Lys Pro Asn 
        115                 120                 125             


Asp Ile Ser Asp Val Thr Thr Ser Ile Ser Asn Met Lys Met Glu Asn 
    130                 135                 140                 


Gly Asn Gly His Glu Asn Gly Lys Asp Pro Leu Ser Leu Gln Asn Val 
145                 150                 155                 160 


Pro Leu Pro Asp Val Ile Lys Cys Ala Tyr Glu Asp Cys Gly Glu Ile 
                165                 170                 175     


Leu Ala Pro Gly Glu Asp Leu Ile Asn His Leu Leu Glu Ser His Leu 
            180                 185                 190         


Val Ser Lys Leu Val Tyr Glu Asp Glu Glu Asp Glu Ser Pro Leu Pro 
        195                 200                 205             


Ser Pro Leu Lys Glu Ala Ser Asp Asp Gln Lys Ser Asp Thr Leu Leu 
    210                 215                 220                 


Gln Gln Ile Gln Asp Lys Pro Val Leu Val Gln Pro Gln Pro Val Pro 
225                 230                 235                 240 


Lys Ser His Pro Ser Leu Pro Pro Pro His His His Tyr Thr Asp Tyr 
                245                 250                 255     


Ser Asn Cys Pro Asp Leu Gly Pro Asp Gly Tyr Ser Glu Trp Thr Asp 
            260                 265                 270         


Leu Ser Cys Arg Asp Cys Thr Tyr Lys Cys Leu Pro Tyr Thr Glu Thr 
        275                 280                 285             


Val Phe Asp Leu Ile Glu His Tyr Asp Gln Asp His Gly Phe Ile Pro 
    290                 295                 300                 


Glu Thr Leu Val Lys Tyr Gly Tyr Ile Asn Leu Tyr Asp Thr Asn Ile 
305                 310                 315                 320 


Ser Asp Leu Thr Thr Ile Pro 
                325         


<210>  7
<211>  458
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Val Ala Asn Trp Val Leu Ala Leu Thr Arg Gln Phe Asp Pro Phe 
1               5                   10                  15      


Met Phe Val Met Val Met Gly Val Gly Ile Ser Ser Asn Ile Leu Tyr 
            20                  25                  30          


Ser Phe Pro Tyr Pro Ala Arg Trp Leu Arg Ile Cys Ser Tyr Ile Met 
        35                  40                  45              


Phe Ala Ile Thr Cys Leu Ile Phe Ile Ala Val Gln Ala Leu Gln Ile 
    50                  55                  60                  


Leu His Leu Ile Val Tyr Ile Lys Glu Lys Ser Phe Arg Glu Tyr Phe 
65                  70                  75                  80  


Asn Asp Phe Phe Arg Asn Met Lys His Asn Leu Phe Trp Gly Thr Tyr 
                85                  90                  95      


Pro Met Gly Leu Val Thr Ile Ile Asn Phe Leu Gly Ala Leu Ser Lys 
            100                 105                 110         


Ala Asn Thr Thr Lys Ser Pro Thr Asn Ala Arg Asn Leu Met Ile Phe 
        115                 120                 125             


Val Tyr Val Leu Trp Trp Tyr Asp Leu Ala Val Cys Leu Val Ile Ala 
    130                 135                 140                 


Trp Gly Ile Ser Phe Leu Ile Trp His Asp Tyr Tyr Ser Leu Glu Gly 
145                 150                 155                 160 


Ile Gly Asn Tyr Pro Ser Tyr Asn Ile Lys Met Ala Ser Glu Asn Met 
                165                 170                 175     


Lys Ser Val Leu Leu Leu Asp Ile Ile Pro Leu Val Val Val Ala Ser 
            180                 185                 190         


Ser Cys Gly Thr Phe Thr Met Ser Glu Ile Phe Phe His Ala Phe Asn 
        195                 200                 205             


Arg Asn Ile Gln Leu Ile Thr Leu Val Ile Cys Ala Leu Thr Trp Leu 
    210                 215                 220                 


His Ala Ile Ile Phe Val Phe Ile Leu Ile Ala Ile Tyr Phe Trp Ser 
225                 230                 235                 240 


Leu Tyr Ile Asn Lys Ile Pro Pro Met Thr Gln Val Phe Thr Leu Phe 
                245                 250                 255     


Leu Leu Leu Gly Pro Met Gly Gln Gly Ser Phe Gly Val Leu Leu Leu 
            260                 265                 270         


Thr Asp Asn Ile Lys Lys Tyr Ala Gly Lys Tyr Tyr Pro Thr Asp Asn 
        275                 280                 285             


Ile Thr Arg Glu Gln Glu Ile Leu Thr Ile Ala Val Pro Trp Cys Phe 
    290                 295                 300                 


Lys Ile Leu Gly Met Val Ser Ala Met Ala Leu Leu Ala Met Gly Tyr 
305                 310                 315                 320 


Phe Phe Thr Val Ile Ser Val Val Ser Ile Leu Ser Tyr Tyr Asn Lys 
                325                 330                 335     


Lys Glu Ile Glu Asn Glu Thr Gly Lys Val Lys Arg Val Tyr Thr Phe 
            340                 345                 350         


His Lys Gly Phe Trp Gly Met Thr Phe Pro Met Gly Thr Met Ser Leu 
        355                 360                 365             


Gly Asn Glu Glu Leu Tyr Val Gln Tyr Asn Gln Tyr Val Pro Leu Tyr 
    370                 375                 380                 


Ala Phe Arg Val Leu Gly Thr Ile Tyr Gly Gly Val Cys Val Cys Trp 
385                 390                 395                 400 


Ser Ile Leu Cys Leu Leu Cys Thr Leu His Glu Tyr Ser Lys Lys Met 
                405                 410                 415     


Leu His Ala Ala Arg Lys Ser Ser Leu Phe Ser Glu Ser Gly Thr Glu 
            420                 425                 430         


Lys Thr Thr Val Ser Pro Tyr Asn Ser Ile Glu Ser Val Glu Glu Ser 
        435                 440                 445             


Asn Ser Ala Leu Asp Phe Thr Arg Leu Ala 
    450                 455             


<210>  8
<211>  458
<212>  PRT
<213>  Saccharomyces paradoxus

<400>  8

Met Val Ala Asn Trp Val Leu Ala Val Thr Arg Gln Phe Asp Pro Phe 
1               5                   10                  15      


Met Phe Val Met Val Met Gly Val Gly Ile Ser Ser Asn Ile Leu Tyr 
            20                  25                  30          


Asn Phe Pro Tyr Pro Ala Arg Trp Leu Arg Ile Cys Ser Tyr Ile Met 
        35                  40                  45              


Phe Ala Ile Thr Cys Leu Ile Phe Ile Ala Val Gln Ala Leu Gln Leu 
    50                  55                  60                  


Leu His Leu Ile Ile Tyr Ile Lys Glu Lys Ser Phe Arg Glu Tyr Phe 
65                  70                  75                  80  


Asn Asp Phe Phe Arg Asn Met Lys His Asn Leu Phe Trp Gly Thr Tyr 
                85                  90                  95      


Pro Met Gly Leu Val Thr Ile Ile Asn Phe Leu Gly Ala Leu Ser Lys 
            100                 105                 110         


Glu Tyr Thr Thr Lys Ser Pro Thr Asn Ala Arg Asn Leu Met Ile Phe 
        115                 120                 125             


Val Tyr Val Leu Trp Trp Tyr Asp Leu Ala Val Ser Leu Val Ile Ala 
    130                 135                 140                 


Trp Gly Ile Ser Phe Leu Ile Trp His Asp Tyr Tyr Ser Leu Glu Gly 
145                 150                 155                 160 


Ile Gly Asn Tyr Pro Ser Tyr Asn Ile Arg Met Ala Ser Glu Asn Met 
                165                 170                 175     


Lys Ser Val Leu Leu Leu Asp Ile Ile Pro Leu Val Val Val Ala Ser 
            180                 185                 190         


Ser Cys Gly Thr Phe Thr Met Ser Glu Ile Phe Gly His Ala Phe Asn 
        195                 200                 205             


Arg Asn Ile Gln Leu Ile Thr Leu Val Ile Cys Ala Leu Thr Trp Leu 
    210                 215                 220                 


His Ala Ile Ile Phe Val Phe Ile Leu Ile Ala Ile Tyr Phe Trp Ser 
225                 230                 235                 240 


Leu Tyr Ile Asn Lys Ile Pro Pro Met Thr Gln Val Phe Thr Leu Phe 
                245                 250                 255     


Leu Leu Leu Gly Pro Met Gly Gln Gly Ser Phe Gly Val Leu Leu Leu 
            260                 265                 270         


Thr Asp Asn Ile Lys Lys Tyr Val Ser Lys Tyr Tyr Gln Thr Asp Asn 
        275                 280                 285             


Val Thr Arg Glu Gln Glu Ile Leu Thr Ile Ala Val Pro Trp Cys Phe 
    290                 295                 300                 


Lys Val Leu Gly Ile Ile Ser Ala Met Ala Leu Leu Ala Met Gly Tyr 
305                 310                 315                 320 


Phe Phe Thr Val Ile Ser Val Ile Ser Ile Leu Ser Tyr Tyr Asn Lys 
                325                 330                 335     


Lys Glu Ile Glu Ser Glu Thr Gly Lys Val Lys Arg Val Tyr Thr Phe 
            340                 345                 350         


His Lys Gly Phe Trp Gly Met Thr Phe Pro Met Gly Thr Met Ser Leu 
        355                 360                 365             


Gly Asn Glu Glu Leu Tyr Val Gln Tyr Asp Gln Tyr Val Pro Leu Tyr 
    370                 375                 380                 


Ala Phe Arg Val Leu Gly Thr Ile Tyr Gly Gly Ile Cys Ile Cys Trp 
385                 390                 395                 400 


Ser Ile Leu Cys Leu Leu Cys Thr Leu His Glu Tyr Ser Lys Lys Ile 
                405                 410                 415     


Leu His Ala Ala Arg Lys Ser Ser Leu Phe Ser Glu Ser Asn Thr Glu 
            420                 425                 430         


Lys Thr Thr Val Ser Pro Tyr Asn Ser Ile Glu Ser Val Glu Glu Ser 
        435                 440                 445             


Asn Ser Ala Leu Asp Phe Thr Arg Leu Ala 
    450                 455             


<210>  9
<211>  458
<212>  PRT
<213>  Saccharomyces mikatae

<400>  9

Met Val Ala Ser Trp Met Phe Ala Ala Thr Arg Gln Phe Asp Pro Phe 
1               5                   10                  15      


Met Phe Val Met Val Met Gly Val Gly Ile Ser Ala Asn Ile Leu Tyr 
            20                  25                  30          


Ser Phe Pro Tyr Pro Ala Arg Trp Leu Arg Ile Cys Ser Tyr Ile Met 
        35                  40                  45              


Phe Ala Ile Thr Cys Leu Ile Phe Ile Ala Val Gln Ala Leu Gln Leu 
    50                  55                  60                  


Leu His Leu Ile Val Tyr Ile Lys Glu Lys Ser Phe Arg Glu Tyr Phe 
65                  70                  75                  80  


Asn Asp Phe Phe Arg Asn Met Lys His Asn Leu Phe Trp Gly Thr Tyr 
                85                  90                  95      


Pro Met Gly Leu Val Thr Ile Ile Asn Phe Leu Ala Thr Leu Ser Lys 
            100                 105                 110         


Glu Tyr Thr Lys Ser Ser Pro Met Ala Ser Arg Asn Leu Met Ile Phe 
        115                 120                 125             


Val Tyr Val Leu Trp Trp Tyr Asp Leu Ala Val Cys Leu Val Thr Ala 
    130                 135                 140                 


Trp Gly Ile Ser Phe Leu Ile Trp His Asp Tyr Tyr Ser Leu Glu Gly 
145                 150                 155                 160 


Ile Gly Asn Tyr Pro Ser Tyr Asn Ile Arg Met Ala Ser Glu Asn Met 
                165                 170                 175     


Lys Ser Ile Leu Leu Leu Asp Ile Ile Pro Leu Val Val Val Ala Ser 
            180                 185                 190         


Ser Cys Gly Thr Phe Thr Met Ser Glu Ile Phe Gly Ile Thr Phe Asn 
        195                 200                 205             


Arg Asn Ile Gln Leu Ile Thr Leu Ile Ile Cys Ala Leu Thr Trp Leu 
    210                 215                 220                 


His Ala Ile Ile Phe Val Phe Ile Leu Ile Thr Ile Tyr Phe Trp Ser 
225                 230                 235                 240 


Leu Tyr Ile Asn Lys Ile Pro Pro Met Thr Gln Val Phe Thr Leu Phe 
                245                 250                 255     


Leu Leu Leu Gly Pro Met Gly Gln Gly Ser Phe Gly Val Leu Leu Leu 
            260                 265                 270         


Ser Asp Asn Ile Lys Glu Tyr Val Gly Lys Tyr Tyr Pro Thr Asp Asn 
        275                 280                 285             


Ile Thr Arg Glu Glu Glu Ile Leu Thr Ile Val Val Pro Trp Cys Phe 
    290                 295                 300                 


Lys Val Leu Gly Met Ile Ser Ala Met Ala Leu Leu Ala Met Gly Tyr 
305                 310                 315                 320 


Phe Phe Thr Val Ile Ser Ile Val Ser Ile Leu Ser Tyr Tyr Asn Glu 
                325                 330                 335     


Arg Glu Thr Glu Asn Glu Thr Gly Lys Val Arg Arg Val Tyr Thr Phe 
            340                 345                 350         


His Lys Gly Phe Trp Gly Met Thr Phe Pro Met Gly Thr Met Ser Leu 
        355                 360                 365             


Gly Asn Glu Glu Leu Tyr Val Gln Tyr Asn Gln Tyr Val Pro Leu Tyr 
    370                 375                 380                 


Ala Phe Arg Val Leu Ala Thr Ile Tyr Gly Gly Ile Cys Val Cys Trp 
385                 390                 395                 400 


Thr Ile Leu Cys Leu Ser Cys Thr Leu Tyr Glu Tyr Thr Lys Lys Ala 
                405                 410                 415     


Leu His Ala Ala His Lys Ser Ser Leu Phe Ser Glu Ala Gly Thr Glu 
            420                 425                 430         


Lys Thr Phe Thr Ser Pro Tyr Asn Ser Thr Glu Ser Val Glu Glu Ser 
        435                 440                 445             


Asn Ser Ala Leu Asp Phe Thr Arg Leu Ala 
    450                 455             


<210>  10
<211>  458
<212>  PRT
<213>  Saccharomyce uvarum

<400>  10

Met Val Ala Ser Trp Met Leu Thr Ala Thr Arg Gln Phe Asn Pro Phe 
1               5                   10                  15      


Met Phe Val Met Val Met Gly Val Gly Ile Ser Ser Asn Ile Leu Tyr 
            20                  25                  30          


Asn Phe Pro Tyr Pro Ala Arg Trp Leu Arg Ile Cys Ser Tyr Ile Met 
        35                  40                  45              


Phe Ala Ile Thr Cys Leu Ile Phe Ile Ala Val Gln Ala Leu Gln Leu 
    50                  55                  60                  


Leu His Met Phe Val Tyr Ile Lys Glu Lys Ser Phe Lys Asp Tyr Phe 
65                  70                  75                  80  


Asn Asp Tyr Phe Arg Ser Leu Lys Phe Asn Leu Phe Trp Gly Thr Tyr 
                85                  90                  95      


Pro Met Gly Leu Val Thr Ile Ile Asn Phe Leu Gly Ala Leu Ser Gln 
            100                 105                 110         


Lys Phe Thr Thr Ser Ser Pro Thr Asn Ala Lys Asn Leu Met Ile Phe 
        115                 120                 125             


Val Tyr Val Leu Trp Trp Tyr Asp Leu Ala Ile Cys Leu Leu Thr Ala 
    130                 135                 140                 


Trp Gly Ile Ser Phe Leu Ile Trp Gln Asp Tyr Tyr Phe Ala Asp Gly 
145                 150                 155                 160 


Val Gly Asn Tyr Ser Ser Tyr Ser Ser Arg Met Ala Ser Asp His Met 
                165                 170                 175     


Lys Ser Val Leu Leu Leu Asp Val Ile Pro Leu Val Val Val Ala Ser 
            180                 185                 190         


Ser Gly Gly Thr Phe Thr Met Ser Gln Ile Phe Gly Thr Thr Phe Asp 
        195                 200                 205             


Arg Asn Ile Gln Leu Leu Thr Leu Val Ile Cys Ala Leu Val Trp Leu 
    210                 215                 220                 


His Ala Leu Ile Phe Val Phe Ile Leu Ile Thr Ile Tyr Phe Trp Asn 
225                 230                 235                 240 


Leu Tyr Ile Asn Lys Ile Pro Pro Met Thr Gln Val Phe Thr Leu Phe 
                245                 250                 255     


Leu Val Leu Gly Pro Leu Gly Gln Gly Ser Phe Gly Ile Leu Leu Leu 
            260                 265                 270         


Thr Asp Asn Ile Arg Lys Tyr Val Glu Lys Tyr Tyr Pro Arg Glu Asn 
        275                 280                 285             


Ile Thr Met Glu Gln Glu Ile Leu Thr Thr Met Val Pro Trp Cys Phe 
    290                 295                 300                 


Lys Val Leu Gly Met Thr Ala Ala Leu Ala Leu Leu Ala Met Gly Tyr 
305                 310                 315                 320 


Phe Phe Thr Val Ile Cys Val Val Ser Ile Leu Ser Tyr Tyr Asn Glu 
                325                 330                 335     


Arg Ile Val Asp Glu Glu Thr Gly Lys Val Lys Arg Val Tyr Thr Phe 
            340                 345                 350         


His Lys Gly Phe Trp Gly Met Thr Phe Pro Met Gly Thr Met Ser Leu 
        355                 360                 365             


Gly Asn Glu Glu Leu Tyr Leu Gln Tyr Asn Gln Tyr Val Pro Leu Tyr 
    370                 375                 380                 


Ala Phe Arg Val Ile Gly Thr Ile Tyr Gly Gly Ile Cys Val Cys Trp 
385                 390                 395                 400 


Ser Ile Leu Cys Leu Ser Cys Thr Leu Tyr Gly Tyr Leu Lys Thr Ala 
                405                 410                 415     


Leu Arg Ala Ala Arg Lys Pro Ser Phe Ile Ser Glu Glu Gly Thr Glu 
            420                 425                 430         


Lys Thr Ala Ser Ser Pro Phe Asn Ser Ile Glu Ser Val Glu Glu Ser 
        435                 440                 445             


Asn Ser Ala Ile Asp Ser Thr Tyr Leu Ala 
    450                 455             


<210>  11
<211>  457
<212>  PRT
<213>  Saccharomyce kudriazevi

<400>  11

Met Val Ser Ser Trp Ala Leu Ala Val Thr Arg Gln Phe Asp Pro Phe 
1               5                   10                  15      


Met Phe Val Met Val Met Gly Val Gly Ile Ser Ser Asn Ile Leu Tyr 
            20                  25                  30          


Asn Phe Pro Tyr Pro Ala Arg Trp Leu Arg Ile Cys Ser Tyr Ile Met 
        35                  40                  45              


Phe Ala Ile Thr Cys Leu Ile Phe Ile Ala Val Gln Ala Leu Gln Leu 
    50                  55                  60                  


Leu His Leu Val Val Tyr Ile Lys Glu Lys Ser Phe Lys Glu Tyr Phe 
65                  70                  75                  80  


Asn Asp Phe Phe Arg Asn Met Lys His Ser Leu Phe Trp Gly Thr Tyr 
                85                  90                  95      


Pro Met Gly Leu Val Thr Ile Ile Asn Phe Leu Gly Ala Leu Ser Lys 
            100                 105                 110         


Lys Tyr Thr Thr Arg Ser Pro Thr Asn Ala Arg Asn Leu Met Ile Leu 
        115                 120                 125             


Val Tyr Ala Leu Trp Trp Tyr Asp Leu Ala Val Cys Leu Val Ile Ala 
    130                 135                 140                 


Trp Gly Ile Ser Phe Leu Ile Trp His Asp Tyr Tyr Ser Leu Asp Gly 
145                 150                 155                 160 


Val Gly Ser Tyr Pro Ser Tyr Asn Ile Arg Met Ala Ser Glu Asn Met 
                165                 170                 175     


Lys Ser Val Leu Leu Leu Asp Ile Ile Pro Leu Val Val Val Ala Ser 
            180                 185                 190         


Ser Cys Gly Thr Phe Thr Met Ser Asp Ile Phe Ala Arg Ala Phe Asn 
        195                 200                 205             


Arg Asn Ile Gln Leu Ile Thr Leu Val Ile Cys Ala Leu Thr Trp Leu 
    210                 215                 220                 


His Ala Ile Ile Phe Val Ser Ile Leu Ile Thr Ile Tyr Phe Trp Ser 
225                 230                 235                 240 


Leu Tyr Ile Asn Lys Ile Pro Pro Met Ser Gln Val Phe Thr Leu Phe 
                245                 250                 255     


Leu Leu Leu Gly Pro Met Gly Gln Gly Ser Phe Gly Val Leu Leu Leu 
            260                 265                 270         


Thr Asp Asn Ile Lys Lys Tyr Val Asp Lys Tyr Tyr Pro Thr Asp Asn 
        275                 280                 285             


Ile Thr Arg Glu Gln Glu Ile Leu Thr Ile Met Val Pro Trp Cys Phe 
    290                 295                 300                 


Lys Val Leu Gly Ile Ile Ser Ala Met Ala Met Leu Ala Met Gly Tyr 
305                 310                 315                 320 


Phe Phe Thr Val Ile Ser Ile Ala Ser Ile Val Ser His Tyr Asp Thr 
                325                 330                 335     


Arg Glu Thr Glu Asn Glu Thr Gly Lys Val Lys Arg Val Tyr Thr Phe 
            340                 345                 350         


His Lys Gly Phe Trp Gly Met Thr Phe Pro Met Gly Thr Met Ser Leu 
        355                 360                 365             


Gly Asn Glu Glu Leu Tyr Val Gln Tyr Asn Gln Tyr Val Pro Leu Tyr 
    370                 375                 380                 


Ala Phe Arg Val Leu Gly Thr Ile Tyr Gly Ser Ile Cys Val Cys Trp 
385                 390                 395                 400 


Ser Ile Leu Cys Leu Ser Phe Thr Leu Tyr Glu Tyr Leu Lys Lys Val 
                405                 410                 415     


Trp His Ala Ala Arg Lys Ser Ser Phe Phe Ser Glu Ala Ala Ala Glu 
            420                 425                 430         


Lys Thr Ile Thr Ser Pro Tyr Ser Thr Glu Ser Val Glu Glu Ser Asn 
        435                 440                 445             


Ser Ala Leu Asp Phe Thr Arg Leu Ala 
    450                 455         


<210>  12
<211>  464
<212>  PRT
<213>  Saccharomyce castelli

<400>  12

Met Leu Ser Leu Ser Phe Asp Pro His Arg Val Ile Arg His Phe Glu 
1               5                   10                  15      


Pro Tyr Leu Phe Val Met Val Met Gly Thr Gly Ile Ser Ala Asp Ile 
            20                  25                  30          


Leu Tyr Ser Phe Pro Tyr Pro Ala Gln Trp Leu Lys Ile Cys Ser Tyr 
        35                  40                  45              


Ile Met Phe Ala Ile Ala Ser Leu Leu Phe Ile Phe Leu Gln Ile Phe 
    50                  55                  60                  


Cys Ile Ile His Leu Ile Trp Tyr Ile Lys Lys Lys Ser Phe Lys Glu 
65                  70                  75                  80  


Tyr Tyr Asp Phe Tyr Phe Arg Asn Met Ser His Asn Val Phe Trp Gly 
                85                  90                  95      


Thr Tyr Pro Met Gly Ile Ile Thr Leu Leu Asn Tyr Leu His Asn Leu 
            100                 105                 110         


Ala Glu Asn Glu Leu Ser His Thr Ala His Ser Arg Arg Ile Met Ile 
        115                 120                 125             


Phe Val Tyr Ala Ile Trp Trp Tyr Asp Leu Phe Ile Ser Leu Leu Ile 
    130                 135                 140                 


Ala Trp Gly Ile Thr Phe Leu Ile Trp Gln Ser Tyr Tyr Ser Lys Asn 
145                 150                 155                 160 


Asp Asn Asp Asn Thr Glu Asp Leu Leu Leu Thr Thr Ala Ser Thr Asn 
                165                 170                 175     


Leu Lys Ser Val Leu Ile Leu Ala Val Val Pro Leu Val Val Ala Ala 
            180                 185                 190         


Ser Ser Ala Gly Leu Phe Thr Met Lys Asp Leu Phe Ala Arg Thr Phe 
        195                 200                 205             


Asn Arg Asn Ile Gln Leu Leu Thr Leu Val Ile Thr Ala Leu Leu Trp 
    210                 215                 220                 


Leu His Ala Leu Ile Phe Val Phe Ile Leu Ile Thr Ile Tyr Phe Trp 
225                 230                 235                 240 


Ser Leu Tyr Val Asn Lys Leu Pro Ala Met Ser Gln Val Phe Thr Leu 
                245                 250                 255     


Phe Leu Val Leu Gly Pro Leu Gly Gln Gly Ser Phe Gly Ile Leu Leu 
            260                 265                 270         


Leu Thr Asp Asn Ile Lys Val Tyr Val Glu Lys Tyr Tyr Pro Gln Pro 
        275                 280                 285             


Thr Gly Gln Asn Leu Gln Gln Ala Ile Leu Leu Thr Ala Ile Pro Trp 
    290                 295                 300                 


Ser Phe Lys Ile Ile Gly Leu Ser Leu Ala Leu Ala Leu Gln Ser Met 
305                 310                 315                 320 


Gly Tyr Phe Phe Thr Ile Ile Cys Phe Val Ser Ile Cys Ser Tyr Cys 
                325                 330                 335     


Thr Thr Glu Ile Gln Asp Asp Asp Thr Gly Lys Lys Ser Arg Ile Tyr 
            340                 345                 350         


Ser Phe His Lys Gly Phe Trp Ala Val Thr Phe Pro Met Gly Thr Met 
        355                 360                 365             


Ser Leu Gly Ser Thr Glu Ile His Val Gln Tyr Glu Gln Phe Val Pro 
    370                 375                 380                 


Leu Ser Ala Phe Arg Val Ile Gly Thr Ile Tyr Ala Ala Val Cys Ile 
385                 390                 395                 400 


Leu Trp Thr Ile Leu Cys Leu Leu Gly Thr Thr Tyr Leu Tyr Ile Trp 
                405                 410                 415     


Pro Pro Ile Gln Arg Tyr Arg His Arg Lys Leu Leu Lys Gly Asp Cys 
            420                 425                 430         


Asp Ile Asp Ser Glu Ser Ile Leu Pro Thr Thr Asn Lys Asn Glu Leu 
        435                 440                 445             


Pro Ser Thr Thr Asn Ser Thr Ser Met Gln Thr Arg Phe Glu Ser His 
    450                 455                 460                 


<210>  13
<211>  515
<212>  PRT
<213>  Saccharomycopsis fibuligera

<400>  13

Met Ile Arg Leu Thr Val Phe Leu Thr Ala Val Phe Ala Ala Val Ala 
1               5                   10                  15      


Ser Cys Val Pro Val Glu Leu Asp Lys Arg Asn Thr Gly His Phe Gln 
            20                  25                  30          


Ala Tyr Ser Gly Tyr Thr Val Ala Arg Ser Asn Phe Thr Gln Trp Ile 
        35                  40                  45              


His Glu Gln Pro Ala Val Ser Trp Tyr Tyr Leu Leu Gln Asn Ile Asp 
    50                  55                  60                  


Tyr Pro Glu Gly Gln Phe Lys Ser Ala Lys Pro Gly Val Val Val Ala 
65                  70                  75                  80  


Ser Pro Ser Thr Ser Glu Pro Asp Tyr Phe Tyr Gln Trp Thr Arg Asp 
                85                  90                  95      


Thr Ala Ile Thr Phe Leu Ser Leu Ile Ala Glu Val Glu Asp His Ser 
            100                 105                 110         


Phe Ser Asn Thr Thr Leu Ala Lys Val Val Glu Tyr Tyr Ile Ser Asn 
        115                 120                 125             


Thr Tyr Thr Leu Gln Arg Val Ser Asn Pro Ser Gly Asn Phe Asp Ser 
    130                 135                 140                 


Pro Asn His Asp Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Asp Thr 
145                 150                 155                 160 


Ala Tyr Thr Ala Ser Trp Gly Arg Pro Gln Asn Asp Gly Pro Ala Leu 
                165                 170                 175     


Arg Ala Tyr Ala Ile Ser Arg Tyr Leu Asn Ala Val Ala Lys His Asn 
            180                 185                 190         


Asn Gly Lys Leu Leu Leu Ala Gly Gln Asn Gly Ile Pro Tyr Ser Ser 
        195                 200                 205             


Ala Ser Asp Ile Tyr Trp Lys Ile Ile Lys Pro Asp Leu Gln His Val 
    210                 215                 220                 


Ser Thr His Trp Ser Thr Ser Gly Phe Asp Leu Trp Glu Glu Asn Gln 
225                 230                 235                 240 


Gly Thr His Phe Phe Thr Ala Leu Val Gln Leu Lys Ala Leu Ser Tyr 
                245                 250                 255     


Gly Ile Pro Leu Ser Lys Thr Tyr Asn Asp Pro Gly Phe Thr Ser Trp 
            260                 265                 270         


Leu Glu Lys Gln Lys Asp Ala Leu Asn Ser Tyr Ile Asn Ser Ser Gly 
        275                 280                 285             


Phe Val Asn Ser Gly Lys Lys His Ile Val Glu Ser Pro Gln Leu Ser 
    290                 295                 300                 


Ser Arg Gly Gly Leu Asp Ser Ala Thr Tyr Ile Ala Ala Leu Ile Thr 
305                 310                 315                 320 


His Asp Ile Gly Asp Asp Asp Thr Tyr Thr Pro Phe Asn Val Asp Asn 
                325                 330                 335     


Ser Tyr Val Leu Asn Ser Leu Tyr Tyr Leu Leu Val Asp Asn Lys Asn 
            340                 345                 350         


Arg Tyr Lys Ile Asn Gly Asn Tyr Lys Ala Gly Ala Ala Val Gly Arg 
        355                 360                 365             


Tyr Pro Glu Asp Val Tyr Asn Gly Val Gly Thr Ser Glu Gly Asn Pro 
    370                 375                 380                 


Trp Gln Leu Ala Thr Ala Tyr Ala Gly Gln Thr Phe Tyr Thr Leu Ala 
385                 390                 395                 400 


Tyr Asn Ser Leu Lys Asn Lys Lys Asn Leu Val Ile Glu Lys Leu Asn 
                405                 410                 415     


Tyr Asp Leu Tyr Asn Ser Phe Ile Ala Asp Leu Ser Lys Ile Asp Ser 
            420                 425                 430         


Ser Tyr Ala Ser Lys Asp Ser Leu Thr Leu Thr Tyr Gly Ser Asp Asn 
        435                 440                 445             


Tyr Lys Asn Val Ile Lys Ser Leu Leu Gln Phe Gly Asp Ser Phe Leu 
    450                 455                 460                 


Lys Val Leu Leu Asp His Ile Asp Asp Asn Gly Gln Leu Thr Glu Glu 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Gly Phe Gln Ala Gly Ala Val Ser Leu Thr Trp 
                485                 490                 495     


Ser Ser Gly Ser Leu Leu Ser Ala Asn Arg Ala Arg Asn Lys Leu Ile 
            500                 505                 510         


Glu Leu Leu 
        515 


<210>  14
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of GLU0111 of Saccharomycopsis fibuligera

<400>  14

Met Ile Arg Leu Thr Val Phe Leu Thr Ala Val Phe Ala Ala Val Ala 
1               5                   10                  15      


Ser Cys Val Pro Val Glu Leu Asp Lys Arg Asn Thr Gly His Phe Gln 
            20                  25                  30          


Ala Tyr Ser Gly Tyr Thr Val Asn Arg Ser Asn Phe Thr Gln Trp Ile 
        35                  40                  45              


His Glu Gln Pro Ala Val Ser Trp Tyr Tyr Leu Leu Gln Asn Ile Asp 
    50                  55                  60                  


Tyr Pro Glu Gly Gln Phe Lys Ser Ala Lys Pro Gly Val Val Val Ala 
65                  70                  75                  80  


Ser Pro Ser Thr Ser Glu Pro Asp Tyr Phe Tyr Gln Trp Thr Arg Asp 
                85                  90                  95      


Thr Ala Ile Thr Phe Leu Ser Leu Ile Ala Glu Val Glu Asp His Ser 
            100                 105                 110         


Phe Ser Asn Thr Thr Leu Ala Lys Val Val Glu Tyr Tyr Ile Ser Asn 
        115                 120                 125             


Thr Tyr Thr Leu Gln Arg Val Ser Asn Pro Ser Gly Asn Phe Asp Ser 
    130                 135                 140                 


Pro Asn His Asp Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Asp Thr 
145                 150                 155                 160 


Ala Tyr Thr Ala Ser Trp Gly Arg Pro Gln Asn Asp Gly Pro Ala Leu 
                165                 170                 175     


Arg Ala Tyr Ala Ile Ser Arg Tyr Leu Asn Ala Val Ala Lys His Asn 
            180                 185                 190         


Asn Gly Lys Leu Leu Leu Ala Gly Gln Asn Gly Ile Pro Tyr Ser Ser 
        195                 200                 205             


Ala Ser Asp Ile Tyr Trp Lys Ile Ile Lys Pro Asp Leu Gln His Val 
    210                 215                 220                 


Ser Thr His Trp Ser Thr Ser Gly Phe Asp Leu Trp Glu Glu Asn Gln 
225                 230                 235                 240 


Gly Thr His Phe Phe Thr Ala Leu Val Gln Leu Lys Ala Leu Ser Tyr 
                245                 250                 255     


Gly Ile Pro Leu Ser Lys Thr Tyr Asn Asp Pro Gly Phe Thr Ser Trp 
            260                 265                 270         


Leu Glu Lys Gln Lys Asp Ala Leu Asn Ser Tyr Ile Asn Ser Ser Gly 
        275                 280                 285             


Phe Val Asn Ser Gly Lys Lys His Ile Val Glu Ser Pro Gln Leu Ser 
    290                 295                 300                 


Ser Arg Gly Gly Leu Asp Ser Ala Thr Tyr Ile Ala Ala Leu Ile Thr 
305                 310                 315                 320 


His Asp Ile Gly Asp Asp Asp Thr Tyr Thr Pro Phe Asn Val Asp Asn 
                325                 330                 335     


Ser Tyr Val Leu Asn Ser Leu Tyr Tyr Leu Leu Val Asp Asn Lys Asn 
            340                 345                 350         


Arg Tyr Lys Ile Asn Gly Asn Tyr Lys Ala Gly Ala Ala Val Gly Arg 
        355                 360                 365             


Tyr Pro Glu Asp Val Tyr Asn Gly Val Gly Thr Ser Glu Gly Asn Pro 
    370                 375                 380                 


Trp Gln Leu Ala Thr Ala Tyr Ala Gly Gln Thr Phe Tyr Thr Leu Ala 
385                 390                 395                 400 


Tyr Asn Ser Leu Lys Asn Lys Lys Asn Leu Val Ile Glu Lys Leu Asn 
                405                 410                 415     


Tyr Asp Leu Tyr Asn Ser Phe Ile Ala Asp Leu Ser Lys Ile Asp Ser 
            420                 425                 430         


Ser Tyr Ala Ser Lys Asp Ser Leu Thr Leu Thr Tyr Gly Ser Asp Asn 
        435                 440                 445             


Tyr Lys Asn Val Ile Lys Ser Leu Leu Gln Phe Gly Asp Ser Phe Leu 
    450                 455                 460                 


Lys Val Leu Leu Asp His Ile Asp Asp Asn Gly Gln Leu Thr Glu Glu 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Gly Phe Gln Ala Gly Ala Val Ser Leu Thr Trp 
                485                 490                 495     


Ser Ser Gly Ser Leu Leu Ser Ala Asn Arg Ala Arg Asn Lys Leu Ile 
            500                 505                 510         


Glu Leu Leu 
        515 


<210>  15
<211>  652
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  15

Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala Gly Pro Ala Ala Ala Asn Ala Glu Thr Ala Asn Lys Ser 
            20                  25                  30          


Asn Asn Val Thr Ala Ser Ser Val Lys Asn Gly Thr Ile Leu His Ala 
        35                  40                  45              


Trp Asn Trp Ser Phe Asn Thr Leu Thr Gln Asn Met Lys Asp Ile Arg 
    50                  55                  60                  


Asp Ala Gly Tyr Ala Ala Ile Gln Thr Ser Pro Ile Asn Gln Val Lys 
65                  70                  75                  80  


Glu Gly Asn Gln Gly Asp Lys Ser Met Arg Asn Trp Tyr Trp Leu Tyr 
                85                  90                  95      


Gln Pro Thr Ser Tyr Gln Ile Gly Asn Arg Tyr Leu Gly Thr Glu Gln 
            100                 105                 110         


Glu Phe Lys Asp Met Cys Ala Ala Ala Glu Lys Tyr Gly Val Lys Val 
        115                 120                 125             


Ile Val Asp Ala Val Ile Asn His Thr Thr Ser Asp Tyr Gly Ala Ile 
    130                 135                 140                 


Ser Asp Glu Ile Lys Arg Ile Pro Asn Trp Thr His Gly Asn Thr Gln 
145                 150                 155                 160 


Ile Lys Asn Trp Ser Asp Arg Trp Asp Val Thr Gln Asn Ser Leu Leu 
                165                 170                 175     


Gly Leu Tyr Asp Trp Asn Thr Gln Asn Thr Glu Val Gln Val Tyr Leu 
            180                 185                 190         


Lys Arg Phe Leu Glu Arg Ala Leu Asn Asp Gly Ala Asp Gly Phe Arg 
        195                 200                 205             


Tyr Asp Ala Ala Lys His Ile Glu Leu Pro Asp Asp Gly Asn Tyr Gly 
    210                 215                 220                 


Ser Gln Phe Trp Pro Asn Ile Thr Asn Thr Ser Ala Glu Phe Gln Tyr 
225                 230                 235                 240 


Gly Glu Ile Leu Gln Asp Ser Ala Ser Arg Asp Thr Ala Tyr Ala Asn 
                245                 250                 255     


Tyr Met Asn Val Thr Ala Ser Asn Tyr Gly His Ser Ile Arg Ser Ala 
            260                 265                 270         


Leu Lys Asn Arg Asn Leu Ser Val Ser Asn Ile Ser His Tyr Ala Ser 
        275                 280                 285             


Asp Val Ser Ala Asp Lys Leu Val Thr Trp Val Glu Ser His Asp Thr 
    290                 295                 300                 


Tyr Ala Asn Asp Asp Glu Glu Ser Thr Trp Met Ser Asp Asp Asp Ile 
305                 310                 315                 320 


Arg Leu Gly Trp Ala Val Ile Gly Ser Arg Ser Gly Ser Thr Pro Leu 
                325                 330                 335     


Phe Phe Ser Arg Pro Glu Gly Gly Gly Asn Gly Val Arg Phe Pro Gly 
            340                 345                 350         


Lys Ser Gln Ile Gly Asp Arg Gly Ser Ala Leu Phe Lys Asp Gln Ala 
        355                 360                 365             


Ile Thr Ala Val Asn Thr Phe His Asn Val Met Ala Gly Gln Pro Glu 
    370                 375                 380                 


Glu Leu Ser Asn Pro Asn Gly Asn Asn Gln Val Phe Met Asn Gln Arg 
385                 390                 395                 400 


Gly Ser Lys Gly Val Val Leu Ala Asn Ala Gly Ser Ser Ser Val Thr 
                405                 410                 415     


Ile Asn Thr Ser Ala Lys Leu Pro Asp Gly Arg Tyr Asp Asn Arg Ala 
            420                 425                 430         


Gly Ala Gly Ser Phe Gln Val Ala Asn Gly Lys Leu Thr Gly Thr Ile 
        435                 440                 445             


Asn Ala Arg Ser Ala Ala Val Leu Tyr Pro Asp Asp Ile Gly Asn Ala 
    450                 455                 460                 


Pro His Val Phe Leu Glu Asn Tyr Gln Thr Gly Ala Val His Ser Phe 
465                 470                 475                 480 


Asn Asp Gln Leu Thr Val Thr Leu Arg Ala Asn Ala Lys Thr Thr Lys 
                485                 490                 495     


Ala Val Tyr Gln Ile Asn Asn Gly Gln Gln Thr Ala Phe Lys Asp Gly 
            500                 505                 510         


Asp Arg Leu Thr Ile Gly Lys Gly Asp Pro Ile Gly Thr Thr Tyr Asn 
        515                 520                 525             


Ile Lys Leu Thr Gly Thr Asn Gly Glu Gly Ala Ala Arg Thr Gln Glu 
    530                 535                 540                 


Tyr Thr Phe Val Lys Lys Asp Pro Ser Gln Thr Asn Ile Ile Gly Tyr 
545                 550                 555                 560 


Gln Asn Pro Asp His Trp Gly Gln Val Asn Ala Tyr Ile Tyr Lys His 
                565                 570                 575     


Asp Gly Gly Arg Ala Ile Glu Leu Thr Gly Ser Trp Pro Gly Lys Ala 
            580                 585                 590         


Met Thr Lys Asn Ala Asn Gly Met Tyr Thr Leu Thr Leu Pro Glu Asn 
        595                 600                 605             


Thr Asp Thr Ala Asn Ala Lys Val Ile Phe Asn Asn Gly Ser Ala Gln 
    610                 615                 620                 


Val Pro Gly Gln Asn Gln Pro Gly Phe Asp Tyr Val Gln Asn Gly Leu 
625                 630                 635                 640 


Tyr Asn Asn Ser Gly Leu Asn Gly Tyr Leu Pro His 
                645                 650         


<210>  16
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide variant


<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Any amino acid except L, preferably S

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Any amino acid except F, preferably I

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  Any amino acid except G, preferably N, S, T, Y, K, P, W

<220>
<221>  VARIANT
<222>  (40)..(40)
<223>  Any amino acid except A, preferably N, S, T, Y, K, P, W

<220>
<221>  VARIANT
<222>  (101)..(101)
<223>  Any amino acid except F, preferably L

<220>
<221>  VARIANT
<222>  (277)..(277)
<223>  Any amino acid except F, preferably L

<220>
<221>  VARIANT
<222>  (487)..(487)
<223>  Any amino acid except F, preferably I

<400>  16

Met Ile Arg Leu Thr Val Phe Xaa Thr Ala Val Xaa Ala Ala Val Ala 
1               5                   10                  15      


Ser Cys Val Pro Val Glu Leu Asp Lys Arg Asn Thr Gly His Phe Gln 
            20                  25                  30          


Ala Tyr Ser Xaa Tyr Thr Val Xaa Arg Ser Asn Phe Thr Gln Trp Ile 
        35                  40                  45              


His Glu Gln Pro Ala Val Ser Trp Tyr Tyr Leu Leu Gln Asn Ile Asp 
    50                  55                  60                  


Tyr Pro Glu Gly Gln Phe Lys Ser Ala Lys Pro Gly Val Val Val Ala 
65                  70                  75                  80  


Ser Pro Ser Thr Ser Glu Pro Asp Tyr Phe Tyr Gln Trp Thr Arg Asp 
                85                  90                  95      


Thr Ala Ile Thr Xaa Leu Ser Leu Ile Ala Glu Val Glu Asp His Ser 
            100                 105                 110         


Phe Ser Asn Thr Thr Leu Ala Lys Val Val Glu Tyr Tyr Ile Ser Asn 
        115                 120                 125             


Thr Tyr Thr Leu Gln Arg Val Ser Asn Pro Ser Gly Asn Phe Asp Ser 
    130                 135                 140                 


Pro Asn His Asp Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Asp Thr 
145                 150                 155                 160 


Ala Tyr Thr Ala Ser Trp Gly Arg Pro Gln Asn Asp Gly Pro Ala Leu 
                165                 170                 175     


Arg Ala Tyr Ala Ile Ser Arg Tyr Leu Asn Ala Val Ala Lys His Asn 
            180                 185                 190         


Asn Gly Lys Leu Leu Leu Ala Gly Gln Asn Gly Ile Pro Tyr Ser Ser 
        195                 200                 205             


Ala Ser Asp Ile Tyr Trp Lys Ile Ile Lys Pro Asp Leu Gln His Val 
    210                 215                 220                 


Ser Thr His Trp Ser Thr Ser Gly Phe Asp Leu Trp Glu Glu Asn Gln 
225                 230                 235                 240 


Gly Thr His Phe Phe Thr Ala Leu Val Gln Leu Lys Ala Leu Ser Tyr 
                245                 250                 255     


Gly Ile Pro Leu Ser Lys Thr Tyr Asn Asp Pro Gly Phe Thr Ser Trp 
            260                 265                 270         


Leu Glu Lys Gln Xaa Asp Ala Leu Asn Ser Tyr Ile Asn Ser Ser Gly 
        275                 280                 285             


Phe Val Asn Ser Gly Lys Lys His Ile Val Glu Ser Pro Gln Leu Ser 
    290                 295                 300                 


Ser Arg Gly Gly Leu Asp Ser Ala Thr Tyr Ile Ala Ala Leu Ile Thr 
305                 310                 315                 320 


His Asp Ile Gly Asp Asp Asp Thr Tyr Thr Pro Phe Asn Val Asp Asn 
                325                 330                 335     


Ser Tyr Val Leu Asn Ser Leu Tyr Tyr Leu Leu Val Asp Asn Lys Asn 
            340                 345                 350         


Arg Tyr Lys Ile Asn Gly Asn Tyr Lys Ala Gly Ala Ala Val Gly Arg 
        355                 360                 365             


Tyr Pro Glu Asp Val Tyr Asn Gly Val Gly Thr Ser Glu Gly Asn Pro 
    370                 375                 380                 


Trp Gln Leu Ala Thr Ala Tyr Ala Gly Gln Thr Phe Tyr Thr Leu Ala 
385                 390                 395                 400 


Tyr Asn Ser Leu Lys Asn Lys Lys Asn Leu Val Ile Glu Lys Leu Asn 
                405                 410                 415     


Tyr Asp Leu Tyr Asn Ser Phe Ile Ala Asp Leu Ser Lys Ile Asp Ser 
            420                 425                 430         


Ser Tyr Ala Ser Lys Asp Ser Leu Thr Leu Thr Tyr Gly Ser Asp Asn 
        435                 440                 445             


Tyr Lys Asn Val Ile Lys Ser Leu Leu Gln Phe Gly Asp Ser Phe Leu 
    450                 455                 460                 


Lys Val Leu Leu Asp His Ile Asp Asp Asn Gly Gln Leu Thr Glu Glu 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Gly Xaa Gln Ala Gly Ala Val Ser Leu Thr Trp 
                485                 490                 495     


Ser Ser Gly Ser Leu Leu Ser Ala Asn Arg Ala Arg Asn Lys Leu Ile 
            500                 505                 510         


Glu Leu Leu 
        515 


<210>  17
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant polypeptide

<400>  17

Met Ile Arg Leu Thr Val Phe Ser Thr Ala Val Ile Ala Ala Val Ala 
1               5                   10                  15      


Ser Cys Val Pro Val Glu Leu Asp Lys Arg Asn Thr Gly His Phe Gln 
            20                  25                  30          


Ala Tyr Ser Asn Tyr Thr Val Ala Arg Ser Asn Phe Thr Gln Trp Ile 
        35                  40                  45              


His Glu Gln Pro Ala Val Ser Trp Tyr Tyr Leu Leu Gln Asn Ile Asp 
    50                  55                  60                  


Tyr Pro Glu Gly Gln Phe Lys Ser Ala Lys Pro Gly Val Val Val Ala 
65                  70                  75                  80  


Ser Pro Ser Thr Ser Glu Pro Asp Tyr Phe Tyr Gln Trp Thr Arg Asp 
                85                  90                  95      


Thr Ala Ile Thr Leu Leu Ser Leu Ile Ala Glu Val Glu Asp His Ser 
            100                 105                 110         


Phe Ser Asn Thr Thr Leu Ala Lys Val Val Glu Tyr Tyr Ile Ser Asn 
        115                 120                 125             


Thr Tyr Thr Leu Gln Arg Val Ser Asn Pro Ser Gly Asn Phe Asp Ser 
    130                 135                 140                 


Pro Asn His Asp Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Asp Thr 
145                 150                 155                 160 


Ala Tyr Thr Ala Ser Trp Gly Arg Pro Gln Asn Asp Gly Pro Ala Leu 
                165                 170                 175     


Arg Ala Tyr Ala Ile Ser Arg Tyr Leu Asn Ala Val Ala Lys His Asn 
            180                 185                 190         


Asn Gly Lys Leu Leu Leu Ala Gly Gln Asn Gly Ile Pro Tyr Ser Ser 
        195                 200                 205             


Ala Ser Asp Ile Tyr Trp Lys Ile Ile Lys Pro Asp Leu Gln His Val 
    210                 215                 220                 


Ser Thr His Trp Ser Thr Ser Gly Phe Asp Leu Trp Glu Glu Asn Gln 
225                 230                 235                 240 


Gly Thr His Phe Phe Thr Ala Leu Val Gln Leu Lys Ala Leu Ser Tyr 
                245                 250                 255     


Gly Ile Pro Leu Ser Lys Thr Tyr Asn Asp Pro Gly Phe Thr Ser Trp 
            260                 265                 270         


Leu Glu Lys Gln Glu Asp Ala Leu Asn Ser Tyr Ile Asn Ser Ser Gly 
        275                 280                 285             


Phe Val Asn Ser Gly Lys Lys His Ile Val Glu Ser Pro Gln Leu Ser 
    290                 295                 300                 


Ser Arg Gly Gly Leu Asp Ser Ala Thr Tyr Ile Ala Ala Leu Ile Thr 
305                 310                 315                 320 


His Asp Ile Gly Asp Asp Asp Thr Tyr Thr Pro Phe Asn Val Asp Asn 
                325                 330                 335     


Ser Tyr Val Leu Asn Ser Leu Tyr Tyr Leu Leu Val Asp Asn Lys Asn 
            340                 345                 350         


Arg Tyr Lys Ile Asn Gly Asn Tyr Lys Ala Gly Ala Ala Val Gly Arg 
        355                 360                 365             


Tyr Pro Glu Asp Val Tyr Asn Gly Val Gly Thr Ser Glu Gly Asn Pro 
    370                 375                 380                 


Trp Gln Leu Ala Thr Ala Tyr Ala Gly Gln Thr Phe Tyr Thr Leu Ala 
385                 390                 395                 400 


Tyr Asn Ser Leu Lys Asn Lys Lys Asn Leu Val Ile Glu Lys Leu Asn 
                405                 410                 415     


Tyr Asp Leu Tyr Asn Ser Phe Ile Ala Asp Leu Ser Lys Ile Asp Ser 
            420                 425                 430         


Ser Tyr Ala Ser Lys Asp Ser Leu Thr Leu Thr Tyr Gly Ser Asp Asn 
        435                 440                 445             


Tyr Lys Asn Val Ile Lys Ser Leu Leu Gln Phe Gly Asp Ser Phe Leu 
    450                 455                 460                 


Lys Val Leu Leu Asp His Ile Asp Asp Asn Gly Gln Leu Thr Glu Glu 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Gly Ile Gln Ala Gly Ala Val Ser Leu Thr Trp 
                485                 490                 495     


Ser Ser Gly Ser Leu Leu Ser Ala Asn Arg Ala Arg Asn Lys Leu Ile 
            500                 505                 510         


Glu Leu Leu 
        515 


<210>  18
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant polypeptide

<400>  18

Met Ile Arg Leu Thr Val Phe Leu Thr Ala Val Phe Ala Ala Val Ala 
1               5                   10                  15      


Ser Cys Val Pro Val Glu Leu Asp Lys Arg Asn Thr Gly His Phe Gln 
            20                  25                  30          


Ala Tyr Ser Gly Tyr Thr Val Asn Arg Ser Asn Phe Thr Gln Trp Ile 
        35                  40                  45              


His Glu Gln Pro Ala Val Ser Trp Tyr Tyr Leu Leu Gln Asn Ile Asp 
    50                  55                  60                  


Tyr Pro Glu Gly Gln Phe Lys Ser Ala Lys Pro Gly Val Val Val Ala 
65                  70                  75                  80  


Ser Pro Ser Thr Ser Glu Pro Asp Tyr Phe Tyr Gln Trp Thr Arg Asp 
                85                  90                  95      


Thr Ala Ile Thr Phe Leu Ser Leu Ile Ala Glu Val Glu Asp His Ser 
            100                 105                 110         


Phe Ser Asn Thr Thr Leu Ala Lys Val Val Glu Tyr Tyr Ile Ser Asn 
        115                 120                 125             


Thr Tyr Thr Leu Gln Arg Val Ser Asn Pro Ser Gly Asn Phe Asp Ser 
    130                 135                 140                 


Pro Asn His Asp Gly Leu Gly Glu Pro Lys Phe Asn Val Asp Asp Thr 
145                 150                 155                 160 


Ala Tyr Thr Ala Ser Trp Gly Arg Pro Gln Asn Asp Gly Pro Ala Leu 
                165                 170                 175     


Arg Ala Tyr Ala Ile Ser Arg Tyr Leu Asn Ala Val Ala Lys His Asn 
            180                 185                 190         


Asn Gly Lys Leu Leu Leu Ala Gly Gln Asn Gly Ile Pro Tyr Ser Ser 
        195                 200                 205             


Ala Ser Asp Ile Tyr Trp Lys Ile Ile Lys Pro Asp Leu Gln His Val 
    210                 215                 220                 


Ser Thr His Trp Ser Thr Ser Gly Phe Asp Leu Trp Glu Glu Asn Gln 
225                 230                 235                 240 


Gly Thr His Phe Phe Thr Ala Leu Val Gln Leu Lys Ala Leu Ser Tyr 
                245                 250                 255     


Gly Ile Pro Leu Ser Lys Thr Tyr Asn Asp Pro Gly Phe Thr Ser Trp 
            260                 265                 270         


Leu Glu Lys Gln Lys Asp Ala Leu Asn Ser Tyr Ile Asn Ser Ser Gly 
        275                 280                 285             


Phe Val Asn Ser Gly Lys Lys His Ile Val Glu Ser Pro Gln Leu Ser 
    290                 295                 300                 


Ser Arg Gly Gly Leu Asp Ser Ala Thr Tyr Ile Ala Ala Leu Ile Thr 
305                 310                 315                 320 


His Asp Ile Gly Asp Asp Asp Thr Tyr Thr Pro Phe Asn Val Asp Asn 
                325                 330                 335     


Ser Tyr Val Leu Asn Ser Leu Tyr Tyr Leu Leu Val Asp Asn Lys Asn 
            340                 345                 350         


Arg Tyr Lys Ile Asn Gly Asn Tyr Lys Ala Gly Ala Ala Val Gly Arg 
        355                 360                 365             


Tyr Pro Glu Asp Val Tyr Asn Gly Val Gly Thr Ser Glu Gly Asn Pro 
    370                 375                 380                 


Trp Gln Leu Ala Thr Ala Tyr Ala Gly Gln Thr Phe Tyr Thr Leu Ala 
385                 390                 395                 400 


Tyr Asn Ser Leu Lys Asn Lys Lys Asn Leu Val Ile Glu Lys Leu Asn 
                405                 410                 415     


Tyr Asp Leu Tyr Asn Ser Phe Ile Ala Asp Leu Ser Lys Ile Asp Ser 
            420                 425                 430         


Ser Tyr Ala Ser Lys Asp Ser Leu Thr Leu Thr Tyr Gly Ser Asp Asn 
        435                 440                 445             


Tyr Lys Asn Val Ile Lys Ser Leu Leu Gln Phe Gly Asp Ser Phe Leu 
    450                 455                 460                 


Lys Val Leu Leu Asp His Ile Asp Asp Asn Gly Gln Leu Thr Glu Glu 
465                 470                 475                 480 


Ile Asn Arg Tyr Thr Gly Phe Gln Ala Gly Ala Val Ser Leu Thr Trp 
                485                 490                 495     


Ser Ser Gly Ser Leu Leu Ser Ala Asn Arg Ala Arg Asn Lys Leu Ile 
            500                 505                 510         


Glu Leu Leu 
        515 


<210>  19
<211>  652
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MP775

<400>  19

Met Leu Leu Gln Ala Phe Leu Phe Leu Leu Ala Gly Phe Ala Ala Lys 
1               5                   10                  15      


Ile Ser Ala Gly Pro Ala Ala Ala Asn Ala Glu Thr Ala Asn Lys Ser 
            20                  25                  30          


Asn Asn Val Thr Ala Ser Ser Val Lys Asn Gly Thr Ile Leu His Ala 
        35                  40                  45              


Trp Asn Trp Ser Phe Asn Thr Leu Thr Gln Asn Met Lys Asp Ile Arg 
    50                  55                  60                  


Asp Ala Gly Tyr Ala Ala Ile Gln Thr Ser Pro Ile Asn Gln Val Lys 
65                  70                  75                  80  


Glu Gly Asn Gln Gly Asp Lys Ser Met Arg Asn Trp Tyr Trp Leu Tyr 
                85                  90                  95      


Gln Pro Thr Ser Tyr Gln Ile Gly Asn Arg Tyr Leu Gly Thr Glu Gln 
            100                 105                 110         


Glu Phe Lys Asp Met Cys Ala Ala Ala Glu Lys Tyr Gly Val Lys Val 
        115                 120                 125             


Ile Val Asp Ala Val Ile Asn His Thr Thr Ser Asp Tyr Gly Ala Ile 
    130                 135                 140                 


Ser Asp Glu Ile Lys Arg Ile Pro Asn Trp Thr His Gly Asn Thr Gln 
145                 150                 155                 160 


Ile Lys Asn Trp Ser Asp Arg Trp Asp Val Thr Gln Asn Ser Leu Leu 
                165                 170                 175     


Gly Leu Tyr Asp Trp Asn Thr Gln Asn Thr Glu Val Gln Val Tyr Leu 
            180                 185                 190         


Lys Arg Phe Leu Glu Arg Ala Leu Asn Asp Gly Ala Asp Gly Phe Arg 
        195                 200                 205             


Tyr Asp Ala Ala Lys His Ile Glu Leu Pro Asp Asp Gly Asn Tyr Gly 
    210                 215                 220                 


Ser Gln Phe Trp Pro Asn Ile Thr Asn Thr Ser Ala Glu Phe Gln Tyr 
225                 230                 235                 240 


Gly Glu Ile Leu Gln Asp Ser Ala Ser Arg Asp Thr Ala Tyr Ala Asn 
                245                 250                 255     


Tyr Met Asn Val Thr Ala Ser Asn Tyr Gly His Ser Ile Arg Ser Ala 
            260                 265                 270         


Leu Lys Asn Arg Asn Leu Ser Val Ser Asn Ile Ser His Tyr Ala Ser 
        275                 280                 285             


Asp Val Ser Ala Asp Lys Leu Val Thr Trp Val Glu Ser His Asp Thr 
    290                 295                 300                 


Tyr Ala Asn Asp Asp Glu Glu Ser Thr Trp Met Ser Asp Asp Asp Ile 
305                 310                 315                 320 


Arg Leu Gly Trp Ala Val Ile Gly Ser Arg Ser Gly Ser Thr Pro Leu 
                325                 330                 335     


Phe Phe Ser Arg Pro Glu Gly Gly Gly Asn Gly Val Arg Phe Pro Gly 
            340                 345                 350         


Lys Ser Gln Ile Gly Asp Arg Gly Ser Ala Leu Phe Lys Asp Gln Ala 
        355                 360                 365             


Ile Thr Ala Val Asn Thr Phe His Asn Val Met Ala Gly Gln Pro Glu 
    370                 375                 380                 


Glu Leu Ser Asn Pro Asn Gly Asn Asn Gln Val Phe Met Asn Gln Arg 
385                 390                 395                 400 


Gly Ser Lys Gly Val Val Leu Ala Asn Ala Gly Ser Ser Ser Val Thr 
                405                 410                 415     


Ile Asn Thr Ser Ala Lys Leu Pro Asp Gly Arg Tyr Asp Asn Arg Ala 
            420                 425                 430         


Gly Ala Gly Ser Phe Gln Val Ala Asn Gly Lys Leu Thr Gly Thr Ile 
        435                 440                 445             


Asn Ala Arg Ser Ala Ala Val Leu Tyr Pro Asp Asp Ile Gly Asn Ala 
    450                 455                 460                 


Pro His Val Phe Leu Glu Asn Tyr Gln Thr Gly Ala Val His Ser Phe 
465                 470                 475                 480 


Asn Asp Gln Leu Thr Val Thr Leu Arg Ala Asn Ala Lys Thr Thr Lys 
                485                 490                 495     


Ala Val Tyr Gln Ile Asn Asn Gly Gln Gln Thr Ala Phe Lys Asp Gly 
            500                 505                 510         


Asp Arg Leu Thr Ile Gly Lys Gly Asp Pro Ile Gly Thr Thr Tyr Asn 
        515                 520                 525             


Ile Lys Leu Thr Gly Thr Asn Gly Glu Gly Ala Ala Arg Thr Gln Glu 
    530                 535                 540                 


Tyr Thr Phe Val Lys Lys Asp Pro Ser Gln Thr Asn Ile Ile Gly Tyr 
545                 550                 555                 560 


Gln Asn Pro Asp His Trp Gly Gln Val Asn Ala Tyr Ile Tyr Lys His 
                565                 570                 575     


Asp Gly Gly Arg Ala Ile Glu Leu Thr Gly Ser Trp Pro Gly Lys Ala 
            580                 585                 590         


Met Thr Lys Asn Ala Asn Gly Met Tyr Thr Leu Thr Leu Pro Glu Asn 
        595                 600                 605             


Thr Asp Thr Ala Asn Ala Lys Val Ile Phe Asn Asn Gly Ser Ala Gln 
    610                 615                 620                 


Val Pro Gly Gln Asn Gln Pro Gly Phe Asp Tyr Val Gln Asn Gly Leu 
625                 630                 635                 640 


Tyr Asn Asn Ser Gly Leu Asn Gly Tyr Leu Pro His 
                645                 650         


<210>  20
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of Figure 7A


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably M

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably M or V

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably A

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably A

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably R

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably V or T

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably D

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably F or S

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably G

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably I or V

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably G

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably G or T

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid, preferably T or A

<220>
<221>  VARIANT
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid, preferably R or K

<220>
<221>  VARIANT
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid, preferably T, P, S
       or L

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid, preferably N, C, 
       K, R or V

<220>
<221>  VARIANT
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid, preferably D, N, 
       H, I or N

<220>
<221>  VARIANT
<222>  (118)..(118)
<223>  Xaa can be any naturally occurring amino acid, preferably R, Y, T
       or D

<220>
<221>  VARIANT
<222>  (132)..(132)
<223>  Xaa can be any naturally occurring amino acid, preferably N, S, G
       or K

<220>
<221>  VARIANT
<222>  (134)..(134)
<223>  Xaa can be any naturally occurring amino acid, preferably K, V, 
       G, N, S or A

<220>
<221>  VARIANT
<222>  (137)..(137)
<223>  Xaa can be any naturally occurring amino acid, preferably G, S, N
       or K

<220>
<221>  VARIANT
<222>  (140)..(140)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably D

<220>
<221>  VARIANT
<222>  (141)..(141)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably I

<220>
<221>  VARIANT
<222>  (143)..(143)
<223>  Xaa can be any naturally occurring amino acid, preferably K, A, 
       I, T, S or D

<220>
<221>  VARIANT
<222>  (149)..(149)
<223>  Xaa can be any naturally occurring amino acid, preferably P, V, L
       or S

<220>
<221>  VARIANT
<222>  (155)..(155)
<223>  Xaa can be any naturally occurring amino acid, preferably F, S, L
       or N

<220>
<221>  VARIANT
<222>  (156)..(156)
<223>  Xaa can be any naturally occurring amino acid, preferably S, L, P
       or G

<220>
<221>  VARIANT
<222>  (165)..(165)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably P

<220>
<221>  VARIANT
<222>  (166)..(166)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably L

<220>
<221>  VARIANT
<222>  (170)..(170)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably N

<220>
<221>  VARIANT
<222>  (171)..(171)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably V

<220>
<221>  VARIANT
<222>  (172)..(172)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably P

<220>
<221>  VARIANT
<222>  (173)..(173)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably L

<220>
<221>  VARIANT
<222>  (174)..(174)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably P

<220>
<221>  VARIANT
<222>  (175)..(175)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably D

<220>
<221>  VARIANT
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid, preferably P, S, L
       or D

<220>
<221>  VARIANT
<222>  (219)..(219)
<223>  Xaa can be any naturally occurring amino acid, preferably S, C, Q
       or P

<220>
<221>  VARIANT
<222>  (220)..(220)
<223>  Xaa can be any naturally occurring amino acid, preferably L, T, A
       or S

<220>
<221>  VARIANT
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid, preferably E, V, A
       or P

<220>
<221>  VARIANT
<222>  (229)..(229)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably Q

<220>
<221>  VARIANT
<222>  (230)..(230)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably K

<220>
<221>  VARIANT
<222>  (231)..(231)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably S

<220>
<221>  VARIANT
<222>  (232)..(232)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably D

<220>
<221>  VARIANT
<222>  (233)..(233)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably T

<220>
<221>  VARIANT
<222>  (234)..(234)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably L

<220>
<221>  VARIANT
<222>  (235)..(235)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably L

<220>
<221>  VARIANT
<222>  (236)..(236)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably Q

<220>
<221>  VARIANT
<222>  (237)..(237)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably Q

<220>
<221>  VARIANT
<222>  (238)..(238)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably I

<220>
<221>  VARIANT
<222>  (239)..(239)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably Q

<220>
<221>  VARIANT
<222>  (240)..(240)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably D

<220>
<221>  VARIANT
<222>  (241)..(241)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably K

<220>
<221>  VARIANT
<222>  (242)..(242)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably P

<220>
<221>  VARIANT
<222>  (243)..(243)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably V

<220>
<221>  VARIANT
<222>  (244)..(244)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably L

<220>
<221>  VARIANT
<222>  (255)..(255)
<223>  Xaa can be any naturally occurring amino acid, preferably F, L, P
       or A

<220>
<221>  VARIANT
<222>  (266)..(266)
<223>  Xaa can be any naturally occurring amino acid, preferably V, S, G
       or D

<220>
<221>  VARIANT
<222>  (267)..(267)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably D, N, K, H or Y

<220>
<221>  VARIANT
<222>  (289)..(289)
<223>  Xaa can be any naturally occurring amino acid, preferably S, T, I
       or C

<220>
<221>  VARIANT
<222>  (305)..(305)
<223>  Xaa can be any naturally occurring amino acid, preferably D or E

<220>
<221>  VARIANT
<222>  (330)..(330)
<223>  Xaa can be any naturally occurring amino acid, preferably S or N

<220>
<221>  VARIANT
<222>  (338)..(338)
<223>  Xaa can be present or absent, when any naturally occurring amino 
       acid, preferably P

<400>  20

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Xaa Asn Thr 
1               5                   10                  15      


Lys Xaa Xaa Lys Ser Arg Xaa Tyr Lys Cys Ser Phe Glu Gly Cys Glu 
            20                  25                  30          


Lys Glu Tyr Asn Arg Pro Ser Leu Leu Gln Gln His Gln Asn Ser His 
        35                  40                  45              


Thr Asn Gln Lys Pro Tyr His Cys Asp Glu Pro Gly Cys Gly Lys Lys 
    50                  55                  60                  


Phe Ile Arg Pro Cys His Leu Arg Val His Lys Trp Thr His Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Lys Pro Cys Thr Leu Cys Glu Lys Arg Phe Val Thr Asn 
                85                  90                  95      


Gln Gln Leu Lys Arg His Leu Asn Ser His Glu Arg Lys Ser Lys Leu 
            100                 105                 110         


Ala Ser Lys Ile Xaa Xaa Lys His Glu Glu Pro Asn Pro Asn Ile Lys 
        115                 120                 125             


Ala Glu Leu Xaa Gly Xaa Glu Gly Xaa Leu Asp Xaa Xaa Pro Xaa Leu 
    130                 135                 140                 


Pro Ser Gly Ser Xaa Met His Asp Glu Glu Xaa Xaa Gln Gly His Leu 
145                 150                 155                 160 


Pro Gly Ser Asp Xaa Xaa Asp Met Gln Xaa Xaa Xaa Xaa Xaa Xaa Val 
                165                 170                 175     


Leu Gln Cys Pro Tyr Lys Ser Cys Gln Lys Val Thr Ser Phe Asn Asp 
            180                 185                 190         


Asp Leu Ile Asn His Met Leu Gln His His Ile Ala Ser Lys Leu Val 
        195                 200                 205             


Val Pro Ser Glu Glu Xaa His Leu Lys Lys Xaa Xaa Pro Thr Ser Xaa 
    210                 215                 220                 


Lys Ser Ser Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Thr Asp Ile Thr Ser Ile Pro Gln Leu Ser Xaa Ser 
                245                 250                 255     


Thr Thr Gly Thr Ser Ser Ser Asp Ser Xaa Xaa Ser Thr Thr Ala Gln 
            260                 265                 270         


Ser Pro Asp Asp Pro Glu Ser Tyr Trp Ser Asp Asn Arg Cys Lys His 
        275                 280                 285             


Xaa Asp Cys Gln Glu Leu Ser Pro Phe Ala Ser Val Phe Asp Leu Ile 
    290                 295                 300                 


Xaa His Tyr Asp His Thr His Ala Phe Ile Pro Glu Thr Leu Val Lys 
305                 310                 315                 320 


Tyr Ser Tyr Ile His Leu Tyr Lys Pro Xaa Val Trp Gly Leu Phe Glu 
                325                 330                 335     


Tyr Xaa 
        


<210>  21
<211>  480
<212>  PRT
<213>  Candida glabrata

<400>  21

Met Ser Tyr Asn Gln Gly Lys Glu Phe Ile Thr Glu Leu Gly Lys Thr 
1               5                   10                  15      


Pro Met Lys Tyr Ile Ile Glu Pro Thr Val Gly Leu Ala Asn Asn Leu 
            20                  25                  30          


Thr Pro His Gly Asp Thr Val Val Asp Glu Ala Lys Lys Ala Lys Lys 
        35                  40                  45              


Gly Arg Thr Lys Ser Gly Arg Lys Tyr Val Cys Gln Ile Asp Gly Cys 
    50                  55                  60                  


Lys Arg Glu Phe Ser Val Pro Ser Leu Leu Ala Gln His Arg Asn Ala 
65                  70                  75                  80  


His Thr Asp Glu Arg Pro Tyr Val Cys Asp Glu Pro Asn Cys Gly Lys 
                85                  90                  95      


Arg Phe Leu Arg Pro Cys His Leu Arg Val His Lys Trp Thr His Ala 
            100                 105                 110         


Gln Val Lys Pro Leu Lys Cys Ser Tyr Cys Glu Arg Arg Phe Ile Thr 
        115                 120                 125             


Asn Gln Gln Leu Lys Arg His Thr Asn Thr His Glu Arg Arg Ile Ala 
    130                 135                 140                 


Ala Ser Lys Lys Lys Glu Thr Glu Ala Ala Met Arg Met Met Val Gly 
145                 150                 155                 160 


Leu Pro Pro Lys Asn Asn Lys Pro Lys Lys Ser Pro Thr Thr Thr Leu 
                165                 170                 175     


Leu Asn Glu Ala Asn Glu Thr Asn Gly Thr Val Asn Gly Ala Ala Asn 
            180                 185                 190         


Gly Thr Thr Asn Gly Val Ile Asn Gly Thr Asp Gly Val Ala Asn Gly 
        195                 200                 205             


Thr Ala Asn Asp Thr Ala Asn Gly Val Thr Asn Gly Val Thr Asn Gly 
    210                 215                 220                 


Val Thr Asn Gly Val Thr Asn Gly Val Ala Asn Gly Val Thr Asn Ser 
225                 230                 235                 240 


Ile Thr Asn Gly Asn Asp Ile Val Asn Gly Asn Asn Tyr Asn Thr Asp 
                245                 250                 255     


Lys Phe Asp Asp Asn Gly Leu Asn Gly Leu Ala Thr Gly Ile His Thr 
            260                 265                 270         


Ile Asn Leu Gln Asp Leu Gly Phe Ser Asp Ile Asn Gly Tyr Arg Leu 
        275                 280                 285             


Asn Asn Thr Ser Leu Leu Ser Asp Pro Val Ile Asp Val Asp Gly Asn 
    290                 295                 300                 


Gly Leu Arg Phe Arg Ile Lys Cys Pro Tyr Phe Asp Cys Asp Ala Ile 
305                 310                 315                 320 


Leu Gly Pro Asn Glu Asp Ile Met Asn His Leu Leu Glu Met His Leu 
                325                 330                 335     


Val Ser Arg Leu Glu Lys Asp Pro Thr Val Asp Gly Glu Leu Phe Tyr 
            340                 345                 350         


Ser Pro Asn Ser Val Val Asn Asn Ser Leu Ser Leu Ser Asp Thr Ala 
        355                 360                 365             


Thr Ser Pro Ser Ser Asp Gly Lys Ser Asp Thr Ser Tyr Leu Leu Asp 
    370                 375                 380                 


Gly Arg Ile Gln Asp Lys Thr Asp Asp Lys Cys Phe Ser Glu Thr Ile 
385                 390                 395                 400 


Pro Asn Asp Ile Ser Tyr Tyr Arg Asn Asn Glu Thr Val Leu Asn Ile 
                405                 410                 415     


Ser Asp His Glu Glu Ala Ser Ser Trp Asn Asp Leu Arg Cys Arg Glu 
            420                 425                 430         


Ala His Cys Lys Asp Leu Pro Lys Phe Asn Asn Val Phe Val Leu Ile 
        435                 440                 445             


Glu His Tyr Asp Gln Asp His Ala Phe Ile Pro Glu Ser Leu Val Lys 
    450                 455                 460                 


Phe Gly Tyr Leu His Leu Tyr Ala Pro Asp Val Gln Asp Gly Val Leu 
465                 470                 475                 480 


<210>  22
<211>  449
<212>  PRT
<213>  Scheffersomyces stipitis

<400>  22

Met Ser Ser Asp Thr Ala Ser Val Thr Ser Thr Gly Ser Ser Ala Leu 
1               5                   10                  15      


Pro Lys Lys Tyr Leu Cys Asp Phe Glu Gly Cys Thr Lys Ala Tyr Ala 
            20                  25                  30          


Lys Pro Ser Leu Leu Glu Gln His Lys Arg Ser His Thr Asn Glu Arg 
        35                  40                  45              


Pro Tyr Lys Cys Ser Ser Pro Asp Cys Gly Lys Ser Phe Met Arg Gln 
    50                  55                  60                  


Ser His Leu Asp Ala His Leu Leu Ser His Ala Asp Asn Gly Thr Lys 
65                  70                  75                  80  


Pro Tyr His Cys Ser Val Cys Gly Lys Gly Val Asn Ser Leu Gln His 
                85                  90                  95      


Leu Lys Arg His Glu Ile Thr His Thr Lys Ser Phe Val Cys Thr His 
            100                 105                 110         


Glu Gly Cys Ser Glu Ser Phe Tyr Lys His Gln Ser Leu Arg His His 
        115                 120                 125             


Ile Leu Ser Val His Glu Arg Thr Leu Ser Cys Ser Ile Cys Asn Lys 
    130                 135                 140                 


Asn Phe Ser Arg Pro Tyr Arg Leu Ala Gln His Asn Leu Lys Tyr His 
145                 150                 155                 160 


Ser Asp Ser Pro Ala Tyr Gln Cys Asp His Ala Gly Cys Phe Ser Asn 
                165                 170                 175     


Phe Lys Thr Trp Ser Ala Leu Gln Leu His Ile Lys Thr Glu His Pro 
            180                 185                 190         


Lys Leu Lys Cys Pro Val Cys Gly Lys Gly Cys Val Gly Arg Lys Gly 
        195                 200                 205             


Leu Arg Ser His Met Ile Ser His Asp Glu Glu Lys Met Ile Lys Leu 
    210                 215                 220                 


Trp Asn Cys Asn Tyr Cys Asn Ile Gly Lys Phe Ser Lys Lys Ile Asp 
225                 230                 235                 240 


Leu Val Glu His Tyr Asn Ser Leu His Asp Gly Asn Ile Pro Glu Asp 
                245                 250                 255     


Leu Leu Lys Pro Asn Glu Lys Met Arg Leu Glu Glu Leu Leu Ser Glu 
            260                 265                 270         


Thr Asp Asp Val Thr Asn Leu Ala Asp Leu Lys Ser Leu Pro Gly Ser 
        275                 280                 285             


Arg Tyr Glu Phe Leu Asp Glu Glu Glu Asp Glu Glu Gln Glu Leu Val 
    290                 295                 300                 


Leu Glu Asn Arg Phe Glu Ala Pro Asn Ser Ile Lys Ser Met Asp Ser 
305                 310                 315                 320 


Phe Glu Asn Ser Leu Arg Arg Ile Ser Val Ile Gly Leu Ile Ser Asn 
                325                 330                 335     


Asn Phe Ser Ser Lys Thr Ile Lys Cys Pro Lys Lys Asn Cys Ala Arg 
            340                 345                 350         


Ala Phe Ser Arg Glu Tyr Asp Leu Thr Arg His Leu Lys Trp His Glu 
        355                 360                 365             


Glu His Met Lys Lys Ile Glu Asp Phe Leu Asn Ser Val Glu Lys Glu 
    370                 375                 380                 


Glu Thr Ile Ser Pro Ser Lys Ile Glu Asp Asp Glu Tyr Asp Ser Ala 
385                 390                 395                 400 


Ser Glu Pro Pro Ser Lys Arg Gln Lys Leu Pro Ala Arg Tyr Glu Thr 
                405                 410                 415     


Leu Thr Asn Asp Asn Asp Asn Asp Asn Asp Asn Asp Asp Asp Leu Asp 
            420                 425                 430         


Ala Leu Ile Asp Val Glu Leu Arg Ser Ile Lys Ala Gly Asp Ser Ser 
        435                 440                 445             


Phe 
    


<210>  23
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of Figure 7C


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably M

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably L

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid, preferably V, M, A
       or P

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid, preferably S or N

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring amino acid, preferably R or K

<220>
<221>  VARIANT
<222>  (115)..(115)
<223>  Xaa can be any naturally occurring amino acid, preferably A, E, K
       or N

<220>
<221>  VARIANT
<222>  (119)..(119)
<223>  Xaa can be any naturally occurring amino acid, preferably K, S, R
       or H

<220>
<221>  VARIANT
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid, preferably F, G or
       A

<220>
<221>  VARIANT
<222>  (208)..(208)
<223>  Xaa can be any naturally occurring amino acid, preferably H, I, T
       or R

<220>
<221>  VARIANT
<222>  (283)..(283)
<223>  Xaa can be any naturally occurring amino acid, preferably G, S, E
       or D

<220>
<221>  VARIANT
<222>  (291)..(291)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably G

<220>
<221>  VARIANT
<222>  (339)..(339)
<223>  Xaa can be any naturally occurring amino acid, preferably K, E or
       T

<220>
<221>  VARIANT
<222>  (342)..(342)
<223>  Xaa can be any naturally occurring amino acid, preferably I, T, V
       or Q

<220>
<221>  VARIANT
<222>  (409)..(409)
<223>  Xaa can be any naturally occurring amino acid, preferably L or S

<220>
<221>  VARIANT
<222>  (416)..(416)
<223>  Xaa can be any naturally occurring amino acid, preferably S, T or
       L

<220>
<221>  VARIANT
<222>  (431)..(431)
<223>  Xaa can be any naturally occurring amino acid, preferably E or G

<220>
<221>  VARIANT
<222>  (433)..(433)
<223>  Xaa can be any naturally occurring amino acid, preferably G, N, A
       or C

<220>
<221>  VARIANT
<222>  (440)..(440)
<223>  Xaa can be any naturally occurring amino acid, preferably T, F, 
       A, I or L

<220>
<221>  VARIANT
<222>  (445)..(445)
<223>  Xaa can be present or absent, when present any naturally 
       occurring amino acid, preferably N

<220>
<221>  VARIANT
<222>  (464)..(464)
<223>  Xaa can be any naturally occurring amino acid, preferably S

<220>
<221>  VARIANT
<222>  (465)..(465)
<223>  Xaa can be any naturally occurring amino acid, preferably H

<400>  23

Xaa Xaa Met Val Ala Ser Trp Xaa Leu Ala Val Thr Arg Gln Phe Asp 
1               5                   10                  15      


Pro Phe Met Phe Val Met Val Met Gly Val Gly Ile Ser Ser Asn Ile 
            20                  25                  30          


Leu Tyr Xaa Phe Pro Tyr Pro Ala Arg Trp Leu Arg Ile Cys Ser Tyr 
        35                  40                  45              


Ile Met Phe Ala Ile Thr Cys Leu Ile Phe Ile Ala Val Gln Ala Leu 
    50                  55                  60                  


Gln Leu Leu His Leu Ile Val Tyr Ile Lys Glu Lys Ser Phe Xaa Glu 
65                  70                  75                  80  


Tyr Phe Asn Asp Phe Phe Arg Asn Met Lys His Asn Leu Phe Trp Gly 
                85                  90                  95      


Thr Tyr Pro Met Gly Leu Val Thr Ile Ile Asn Phe Leu Gly Ala Leu 
            100                 105                 110         


Ser Lys Xaa Tyr Thr Thr Xaa Ser Pro Thr Asn Ala Arg Asn Leu Met 
        115                 120                 125             


Ile Phe Val Tyr Val Leu Trp Trp Tyr Asp Leu Ala Val Cys Leu Val 
    130                 135                 140                 


Ile Ala Trp Gly Ile Ser Phe Leu Ile Trp His Asp Tyr Tyr Ser Leu 
145                 150                 155                 160 


Glu Gly Ile Gly Asn Tyr Pro Ser Tyr Asn Ile Arg Met Ala Ser Glu 
                165                 170                 175     


Asn Met Lys Ser Val Leu Leu Leu Asp Ile Ile Pro Leu Val Val Val 
            180                 185                 190         


Ala Ser Ser Cys Gly Thr Phe Thr Met Ser Glu Ile Phe Gly Xaa Xaa 
        195                 200                 205             


Phe Asn Arg Asn Ile Gln Leu Ile Thr Leu Val Ile Cys Ala Leu Thr 
    210                 215                 220                 


Trp Leu His Ala Ile Ile Phe Val Phe Ile Leu Ile Thr Ile Tyr Phe 
225                 230                 235                 240 


Trp Ser Leu Tyr Ile Asn Lys Ile Pro Pro Met Thr Gln Val Phe Thr 
                245                 250                 255     


Leu Phe Leu Leu Leu Gly Pro Met Gly Gln Gly Ser Phe Gly Val Leu 
            260                 265                 270         


Leu Leu Thr Asp Asn Ile Lys Lys Tyr Val Xaa Lys Tyr Tyr Pro Thr 
        275                 280                 285             


Asp Asn Xaa Ile Thr Arg Glu Gln Glu Ile Leu Thr Ile Ala Val Pro 
    290                 295                 300                 


Trp Cys Phe Lys Val Leu Gly Met Ile Ser Ala Met Ala Leu Leu Ala 
305                 310                 315                 320 


Met Gly Tyr Phe Phe Thr Val Ile Ser Val Val Ser Ile Leu Ser Tyr 
                325                 330                 335     


Tyr Asn Xaa Arg Glu Xaa Glu Asn Glu Thr Gly Lys Val Lys Arg Val 
            340                 345                 350         


Tyr Thr Phe His Lys Gly Phe Trp Gly Met Thr Phe Pro Met Gly Thr 
        355                 360                 365             


Met Ser Leu Gly Asn Glu Glu Leu Tyr Val Gln Tyr Asn Gln Tyr Val 
    370                 375                 380                 


Pro Leu Tyr Ala Phe Arg Val Leu Gly Thr Ile Tyr Gly Gly Ile Cys 
385                 390                 395                 400 


Val Cys Trp Ser Ile Leu Cys Leu Xaa Cys Thr Leu Tyr Glu Tyr Xaa 
                405                 410                 415     


Lys Lys Ala Leu His Ala Ala Arg Lys Ser Ser Leu Phe Ser Xaa Glu 
            420                 425                 430         


Xaa Gly Thr Glu Lys Thr Thr Xaa Ser Pro Tyr Asn Xaa Ser Ile Glu 
        435                 440                 445             


Ser Val Glu Glu Ser Asn Ser Ala Leu Asp Phe Thr Arg Leu Ala Xaa 
    450                 455                 460                 


Xaa 
465 


<210>  24
<211>  451
<212>  PRT
<213>  Candida glabrata

<400>  24

Met Arg Arg Leu Met Lys Gln Leu Val Arg Asp Phe Glu Pro Phe Met 
1               5                   10                  15      


Phe Val Met Val Met Ala Ser Gly Ile Ser Ser Asn Leu Leu Tyr Asp 
            20                  25                  30          


Phe Ala Phe Pro Ser His Trp Met Arg Val Cys Ser Tyr Ile Met Phe 
        35                  40                  45              


Gly Ile Ala Cys Ala Ile Phe Ile Val Leu Gln Ile Tyr Val Phe Val 
    50                  55                  60                  


His Ala Tyr Tyr Ser Ile Lys Lys Asp Ser Phe Lys Val Tyr Phe Lys 
65                  70                  75                  80  


Arg Tyr Tyr Ala Gly Val Thr Tyr Gly Pro Phe Trp Gly Ala Tyr Pro 
                85                  90                  95      


Met Gly Leu Ala Thr Ile Ile Asn Tyr Ile Ser Phe Leu Ala Asn Asn 
            100                 105                 110         


Glu Ala Ala Gly Thr Gly Asn Ala Lys Arg Leu Ile Val Leu Ala Tyr 
        115                 120                 125             


Ala Leu Trp Trp Tyr Asp Gln Leu Ile Ser Leu Leu Thr Ala Trp Gly 
    130                 135                 140                 


Val Ser Phe Leu Ile Trp Gln Lys Tyr Asp Phe Asp Lys Asn Asp Ile 
145                 150                 155                 160 


Ser Pro His Val Thr Pro Asn Gln Lys Ser Ala Ala Glu Thr Leu Lys 
                165                 170                 175     


Ser Val Leu Leu Leu Gly Val Ile Pro Leu Val Val Ala Ser Ser Ser 
            180                 185                 190         


Leu Gly Gly Phe Thr Met Ser Pro Ile Phe Ile Lys Tyr Phe Gly Arg 
        195                 200                 205             


His Ile Gln Leu Leu Asn Ile Phe Val Cys Ala Leu Ser Leu Phe His 
    210                 215                 220                 


Ala Leu Ile Phe Val Phe Phe Ile Ile Thr Ile Tyr Ile Trp Ser Leu 
225                 230                 235                 240 


Tyr Val Asn Lys Ile Pro Pro Met Gly Gln Val Phe Ser Met Phe Leu 
                245                 250                 255     


Ile Leu Gly Pro Leu Gly Gln Gly Ser Tyr Ser Phe Leu Leu Ile Gly 
            260                 265                 270         


Glu Asn Val Glu Lys Tyr Thr His Leu Tyr Tyr Arg Pro Gly His Pro 
        275                 280                 285             


Tyr Tyr Asn Glu Leu Leu Val Glu Ile Ile Pro Trp Cys Phe Lys Ile 
    290                 295                 300                 


Ile Phe Leu Leu Leu Val Leu Ala Leu Val Ser Leu Gly Tyr Phe Phe 
305                 310                 315                 320 


Thr Phe Leu Cys Phe Ile Ser Ile Leu Ser Tyr Ser Lys Thr Lys Asp 
                325                 330                 335     


Ala Thr Gly Pro Lys Val Lys Arg Ile Tyr Thr Phe His Lys Gly Trp 
            340                 345                 350         


Leu Gly Met Thr Phe Pro Met Gly Thr Met Ser Leu Ala Asn Lys Glu 
        355                 360                 365             


Ile Tyr Val Ile Tyr Asn Asn Tyr Val Pro Val Lys Thr Phe Arg Tyr 
    370                 375                 380                 


Ile Gly Ala Ile Tyr Gly Gly Val Cys Ile Cys Trp Thr Ile Ile Cys 
385                 390                 395                 400 


Leu Thr Leu Thr Leu Leu Gln Ser Ile Ile Lys Pro Val Tyr Phe Arg 
                405                 410                 415     


Tyr Ser Lys Trp Lys Glu Thr Glu Glu Asn Thr Ser Thr Glu Lys Ser 
            420                 425                 430         


Leu Glu Ser Ser Asn Asp Ile Gln Glu Ser Cys Gln Asp Asp Phe Thr 
        435                 440                 445             


Arg Leu Leu 
    450     


<210>  25
<211>  458
<212>  PRT
<213>  Zygosaccharomyces bailii

<400>  25

Met Val Leu Asn Lys Glu Ile Arg Ile Phe Ala Ser Trp Phe His Pro 
1               5                   10                  15      


Phe Leu Phe Val Met Val Met Gly Thr Gly Ile Ala Ser Asn Leu Leu 
            20                  25                  30          


Phe Asn Phe Pro Tyr Glu Ala Arg Trp Leu Arg Ile Cys Ser Tyr Pro 
        35                  40                  45              


Met Phe Gly Leu Ala Val Leu Leu Leu Leu Tyr Phe His Leu Leu His 
    50                  55                  60                  


Leu Val His Leu Ile Val Phe Val Lys Asp Asn Ser Trp Lys Ala Tyr 
65                  70                  75                  80  


Met Asp Lys Tyr Phe Arg Asp Thr Thr Ile Asn Gly Cys Trp Gly Thr 
                85                  90                  95      


Tyr Pro Met Gly Phe Ile Thr Ile Ile Asn Tyr Ile Phe Gln Leu Ala 
            100                 105                 110         


Arg Asn Arg Val Glu Ser Arg Val Arg Ala Lys His Met Ile Arg Leu 
        115                 120                 125             


Ala Tyr Val Met Trp Trp Tyr Ile Leu Thr Ile Ser Leu Leu Cys Thr 
    130                 135                 140                 


Trp Gly Ile Thr Tyr Ala Val Trp Gln Lys Gln Tyr Lys Lys Gly Gly 
145                 150                 155                 160 


Lys Asp Ser Tyr Lys Ser Tyr Glu Glu Lys Val Ile Phe Glu Gln Leu 
                165                 170                 175     


Asn Thr Ser Leu Leu Leu Ile Val Ile Pro Leu Val Val Ala Cys Ser 
            180                 185                 190         


Cys Gly Gly Leu Leu Thr Ser Ala Asp Leu Phe Pro Glu Ala Phe Asn 
        195                 200                 205             


Arg Asn Ile His Leu Met Thr Ile Val Ile Thr Met Leu Thr Trp Leu 
    210                 215                 220                 


His Ser Leu Gly Phe Val Ala Leu Leu Phe Ala Ile Asn Phe Trp Asn 
225                 230                 235                 240 


Leu Tyr Val Asn Lys Leu Pro Ser Met Leu Lys Val Phe Thr Ile Phe 
                245                 250                 255     


Leu Phe Leu Gly Pro Met Gly Gln Gly Ala Tyr Gly Ile Asn Leu Ile 
            260                 265                 270         


Thr Glu Asn Ile Arg Leu Tyr Val Glu Arg Asn Tyr Pro Thr Ser Gly 
        275                 280                 285             


Ser Asp Phe Gln Arg Asp Val Leu Leu Leu Ala Val Pro Trp Cys Phe 
    290                 295                 300                 


Lys Ile Ile Gly Leu Ile Leu Ala Leu Leu Leu Leu Ala Phe Gly Tyr 
305                 310                 315                 320 


Phe Phe Thr Val Ile Gly Phe Val Ser Ile Ala Ser Tyr Leu Ser Thr 
                325                 330                 335     


Ser Val Glu Thr Thr Val Gly Glu Asp Val Lys Arg Arg Arg Ile Tyr 
            340                 345                 350         


Asn Phe His Arg Gly Trp Phe Ala Met Thr Phe Pro Met Gly Thr Met 
        355                 360                 365             


Ser Leu Gly Ser Thr Ser Ile Trp Asp Leu Tyr Asn Asp Tyr Val Pro 
    370                 375                 380                 


Met Lys Thr Phe Arg Val Leu Gly Ala Ile Tyr Ala Val Ile Ser Ile 
385                 390                 395                 400 


Phe Trp Thr Leu Val Cys Met Thr Gly Thr Val Tyr Gln Ser Val Leu 
                405                 410                 415     


Pro Arg Ile Lys Thr Phe Cys Thr Gln Ala His Asp Lys Gly Gln Glu 
            420                 425                 430         


Thr Asp Ala Thr Gly Arg Thr Ser Lys Glu Leu Pro Ile Thr Thr Ser 
        435                 440                 445             


Gln Pro Leu Glu Ser Tyr Ile Ser Thr Pro 
    450                 455             


