                         SEQUENCE LISTING

<110>  UNIVERSITE DE MONTPELLIER
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       CENTRE HOSPITALIER ET UNIVERSITAIRE DE MONTPELLIER
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER (ENSCM)
 
<120>  New stapled-peptides and uses thereof

<130>  373509D36772

<150>  EP16306788
<151>  2016-12-22

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  linear peptide IRAK2 54-71

<400>  1

Val Ser Ile Thr Arg Glu Leu Leu Trp Trp Trp Gly Met Arg Gln Ala 
1               5                   10                  15      


Thr Val 
        


<210>  2
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  linear peptide IRAKM 66-83

<400>  2

Lys Ser Gly Thr Arg Glu Leu Leu Trp Ser Trp Ala Gln Lys Asn Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  3
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAK2 S1 (JMV6645)


<220>
<221>  BINDING
<222>  (1)..(5)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  3

Xaa Arg Glu Leu Xaa Trp Trp Trp Gly Xaa Arg Gln Ala 
1               5                   10              


<210>  4
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAK2 S2 (JMV6646)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (5)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  4

Arg Arg Glu Leu Xaa Trp Trp Trp Xaa Xaa Arg Gln Ala 
1               5                   10              


<210>  5
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAKM S1 (JMV6647)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  5

Lys Ser Gly Xaa Arg Glu Leu Xaa Trp Ser Trp Ala Gln Lys 
1               5                   10                  


<210>  6
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAKM S2 (JMV6648)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (5)..(9)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  AMIDATION

<400>  6

Arg Arg Glu Leu Xaa Trp Ser Trp Xaa Gln Lys 
1               5                   10      


<210>  7
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  linear peptide IRAK2 Li


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  7

Arg Arg Glu Leu Leu Trp Trp Trp Gly Xaa Arg Gln Ala 
1               5                   10              


<210>  8
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  linear peptide IRAKM Li


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  AMIDATION

<400>  8

Arg Arg Glu Leu Leu Trp Ser Trp Ala Gln Lys 
1               5                   10      


<210>  9
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide Mock-S


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  AMIDATION

<400>  9

Ile Thr Phe Xaa Asn Leu Leu Xaa Tyr Tyr Gly Pro 
1               5                   10          


<210>  10
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAK2 (JMV6650)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  10

Val Ser Ile Xaa Arg Glu Leu Xaa Trp Trp Trp Gly Xaa Arg Gln Ala 
1               5                   10                  15      


Thr Val 
        


<210>  11
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAKM (JMV6649)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is a (S)-2-(4'-pentenyl)alanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  11

Lys Ser Gly Xaa Arg Glu Leu Xaa Trp Ser Trp Ala Gln Lys Asn Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  12
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAK2 (JMV6651)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (1)..(5)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  AMIDATION

<400>  12

Lys Arg Glu Leu Asp Trp Trp Trp Gly Xaa Arg Gln Ala 
1               5                   10              


<210>  13
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAK2 (JMV6652)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  Xaa is Nle

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  13

Val Ser Ile Lys Arg Glu Leu Asp Trp Trp Trp Gly Xaa Arg Gln Ala 
1               5                   10                  15      


Thr Val 
        


<210>  14
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAKM (JMV6653)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  AMIDATION

<400>  14

Lys Ser Gly Lys Arg Glu Leu Asp Trp Ser Trp Ala Gln Lys 
1               5                   10                  


<210>  15
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  stapled peptide IRAKM (JMV6654)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  BINDING
<222>  (4)..(8)

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  AMIDATION

<400>  15

Lys Ser Gly Lys Arg Glu Leu Asp Trp Ser Trp Ala Gln Lys Asn Lys 
1               5                   10                  15      


Thr Ile 
        


