                         SEQUENCE LISTING

<110>  UCB Biopharma SPRL
       Five Prime Therapeutics, Inc.
 
<120>  MEDICAL USE OF INTERFERON-LAMBDA FOR THE TREATMENT OF FIBROSIS

<130>  N412246WO

<140>  PCT/EP2017/083949
<141>  2017-12-20

<150>  GB 1621728.3
<151>  2016-12-20

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp 
                85                  90                  95      


Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys 
            100                 105                 110         


Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly 
    130                 135                 140                 


Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg 
145                 150                 155                 160 


Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr 
                165                 170                 175     


His Pro Glu Ser Thr 
            180     


<210>  2
<211>  856
<212>  DNA
<213>  Homo sapiens

<400>  2
aattaccttt tcactttaca cacatcatct tggattgccc attttgcgtg gctaaaaagc       60

agagccatgc cgctggggaa gcagttgcga tttagccatg gctgcagctt ggaccgtggt      120

gctggtgact ttggtgctag gcttggccgt ggcaggccct gtccccactt ccaagcccac      180

cacaactggg aagggctgcc acattggcag gttcaaatct ctgtcaccac aggagctagc      240

gagcttcaag aaggccaggg acgccttgga agagtcactc aagctgaaaa actggagttg      300

cagctctcct gtcttccccg ggaattggga cctgaggctt ctccaggtga gggagcgccc      360

tgtggccttg gaggctgagc tggccctgac gctgaaggtc ctggaggccg ctgctggccc      420

agccctggag gacgtcctag accagcccct tcacaccctg caccacatcc tctcccagct      480

ccaggcctgt atccagcctc agcccacagc agggcccagg ccccggggcc gcctccacca      540

ctggctgcac cggctccagg aggcccccaa aaaggagtcc gctggctgcc tggaggcatc      600

tgtcaccttc aacctcttcc gcctcctcac gcgagacctc aaatatgtgg ccgatgggaa      660

cctgtgtctg agaacgtcaa cccaccctga gtccacctga caccccacac cttatttatg      720

cgctgagccc tactccttcc ttaatttatt tcctctcacc ctttatttat gaagctgcag      780

ccctgactga gacatagggc tgagtttatt gttttacttt tatacattat gcacaaataa      840

acaacaagga attgga                                                      856


<210>  3
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Pro Val Ala Arg Leu His Gly Ala Leu Pro Asp Ala Arg Gly Cys 
1               5                   10                  15      


His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe 
            20                  25                  30          


Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys 
        35                  40                  45              


Arg Cys His Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu 
    50                  55                  60                  


Gln Val Arg Glu Arg Pro Met Ala Leu Glu Ala Glu Leu Ala Leu Thr 
65                  70                  75                  80  


Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Val Asp 
                85                  90                  95      


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Phe 
            100                 105                 110         


Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly 
        115                 120                 125             


Arg Leu His His Trp Leu Tyr Arg Leu Gln Glu Ala Pro Lys Lys Glu 
    130                 135                 140                 


Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
145                 150                 155                 160 


Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val 
                165                 170                 175 


<210>  4
<211>  734
<212>  DNA
<213>  Homo sapiens

<400>  4
tgggtgacag cctcagagtg tttcttctgc tgacaaagac cagagatcag gaatgaaact       60

agacatgact ggggactgca cgccagtgct ggtgctgatg gccgcagtgc tgaccgtgac      120

tggagcagtt cctgtcgcca ggctccacgg ggctctcccg gatgcaaggg gctgccacat      180

agcccagttc aagtccctgt ctccacagga gctgcaggcc tttaagaggg ccaaagatgc      240

cttagaagag tcgcttctgc tgaaggactg caggtgccac tcccgcctct tccccaggac      300

ctgggacctg aggcagctgc aggtgaggga gcgccccatg gctttggagg ctgagctggc      360

cctgacgctg aaggttctgg aggccaccgc tgacactgac ccagccctgg tggacgtctt      420

ggaccagccc cttcacaccc tgcaccatat cctctcccag ttccgggcct gtatccagcc      480

tcagcccacg gcagggccca ggacccgggg ccgcctccac cattggctgt accggctcca      540

ggaggcccca aaaaaggagt cccctggctg cctcgaggcc tctgtcacct tcaacctctt      600

ccgcctcctc acgcgagacc tgaattgtgt tgccagtggg gacctgtgtg tctgaccctc      660

ccaccagtca tgcaacctga gattttattt ataaattagc cacttgtctt aatttattgc      720

cacccagtcg ctat                                                        734


<210>  5
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Pro Val Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys 
1               5                   10                  15      


His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe 
            20                  25                  30          


Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys 
        35                  40                  45              


Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu 
    50                  55                  60                  


Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr 
65                  70                  75                  80  


Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp 
                85                  90                  95      


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
            100                 105                 110         


Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly 
        115                 120                 125             


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
    130                 135                 140                 


Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
145                 150                 155                 160 


Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val 
                165                 170                 175 


<210>  6
<211>  656
<212>  DNA
<213>  Homo sapiens

<400>  6
ctgcattccc tcagctccct ttctctctgt gacacagaca tgaccgggga ctgcatgcca       60

gtgctggtgc tgatggccgc agtgctgacc gtgactggag cagttcctgt cgccaggctc      120

cgcggggctc tcccggatgc aaggggctgc cacatagccc agttcaagtc cctgtctcca      180

caggagctgc aggcctttaa gagggccaaa gatgccttag aagagtcgct tctgctgaag      240

gactgcaagt gccgctcccg cctcttcccc aggacctggg acctgaggca gctgcaggtg      300

agggagcgcc ccgtggcttt ggaggctgag ctggccctga cgctgaaggt tctggaggcc      360

accgctgaca ctgacccagc cctgggggat gtcttggacc agccccttca caccctgcac      420

catatcctct cccagctccg ggcctgtatc cagcctcagc ccacggcagg gcccaggacc      480

cggggccgcc tccaccattg gctgcaccgg ctccaggagg ccccaaaaaa ggagtcccct      540

ggctgcctcg aggcctctgt caccttcaac ctcttccgcc tcctcacgcg agacctgaat      600

tgtgttgcca gcggggacct gtgtgtctga cccttccgcc agtcatgcaa cctgag          656


<210>  7
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ala Pro Arg Arg Cys Leu Leu Ser His Tyr Arg Ser Leu Glu Pro 
1               5                   10                  15      


Arg Thr Leu Ala Ala Ala Lys Ala Leu Arg Asp Arg Tyr Glu Glu Glu 
            20                  25                  30          


Ala Leu Ser Trp Gly Gln Arg Asn Cys Ser Phe Arg Pro Arg Arg Asp 
        35                  40                  45              


Pro Pro Arg Pro Ser Ser Cys Ala Arg Leu Arg His Val Ala Arg Gly 
    50                  55                  60                  


Ile Ala Asp Ala Gln Ala Val Leu Ser Gly Leu His Arg Ser Glu Leu 
65                  70                  75                  80  


Leu Pro Gly Ala Gly Pro Ile Leu Glu Leu Leu Ala Ala Ala Gly Arg 
                85                  90                  95      


Asp Val Ala Ala Cys Leu Glu Leu Ala Arg Pro Gly Ser Ser Arg Lys 
            100                 105                 110         


Val Pro Gly Ala Gln Lys Arg Arg His Lys Pro Arg Arg Ala Asp Ser 
        115                 120                 125             


Pro Arg Cys Arg Lys Ala Ser Val Val Phe Asn Leu Leu Arg Leu Leu 
    130                 135                 140                 


Thr Trp Glu Leu Arg Leu Ala Ala His Ser Gly Pro Cys Leu 
145                 150                 155             


<210>  8
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  8
atgcggccga gtgtctgggc cgcagtggcc gcggggctgt gggtcctgtg cacggtgatc       60

gcagcggccc cccggcgctg cctgctctcg cactaccgct cgctggagcc ccggacgctg      120

gcggctgcca aggcgctgag ggaccgctac gaggaagagg cgctgagctg ggggcagcgc      180

aactgctcct tccgccccag gagggatcct ccgcggccat cgtcctgcgc tcggctccgc      240

cacgtggccc ggggcatcgc ggacgcccag gcagtgctca gcggcctgca ccgctcggag      300

ctgctccccg gcgccggccc gatcctggag ctgctggcgg ccgcggggag ggatgtggcg      360

gcctgccttg agctggcacg gccaggctcc tccaggaagg tccccggggc ccagaagagg      420

cgtcacaaac cccggagagc ggactcgcct cggtgccgca aagccagcgt ggtcttcaac      480

ctcctgcgcc tgctcacgtg ggagctccgg ctggctgcac actctgggcc ttgcctctga      540


