                         SEQUENCE LISTING

<110>  Institut Pasteur
       Institut National de la Recherche Agronomique
       The United States of America, as represented by the 
       Secretary of Agriculture
 
<120>  ANTIGENIC TRIPEPTIDES DERIVED FROM MYCOBACTERIUM AVIUM SUBSP. 
       PARATUBERCULOSIS S-TYPE STRAINS, DERIVATIVES AND USES THEREOF

<130>  B12263A CS

<150>  PCT/IB2016/002018
<151>  2016-12-20

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  O-methylation

<400>  1

Phe Val Ala 
1           


<210>  2
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  O-methylation

<400>  2

Phe Val Ala 
1           


<210>  3
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  O-methylation

<400>  3

Phe Val Ala 
1           


<210>  4
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<400>  4

Phe Val Ala 
1           


<210>  5
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  O-methylation

<400>  5

Phe Val Ala 
1           


<210>  6
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<400>  6

Phe Val Ala 
1           


<210>  7
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<400>  7

Phe Val Ala 
1           


<210>  8
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Phe Val Ala 
1           


<210>  9
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  amidation of the C-terminus

<400>  9

Phe Val Ala 
1           


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  10
gtgcagtacg ccgactacac                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
agaaaccgat cagctcgtcg                                                   20


<210>  12
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
accgggaaaa cagcagtg                                                     18


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  13

Phe Val Ile Phe Ala 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  O-methylation

<400>  14

Phe Val Ile Phe Ala 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  D-phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  N-methylation

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  amidation of the C-terminus

<400>  15

Phe Val Ile Phe Ala 
1               5   


<210>  16
<211>  4274
<212>  PRT
<213>  Mycobacterium avium

<400>  16

Met Lys Arg Gly Asp Arg Ala Tyr Pro Val Thr Arg Gly Gln Leu Asp 
1               5                   10                  15      


Ile Trp Leu Ala Glu Gln Thr Gly His Leu Asp Val Ala Trp Gln Leu 
            20                  25                  30          


Gly Val Leu Val Arg Ile Asp Gly Ala Ile Asp Pro Ala Leu Leu His 
        35                  40                  45              


Gln Thr Met Arg His Val Val Gly Glu Ala Glu Ser Leu Arg Ala Ser 
    50                  55                  60                  


Phe Phe Glu Ala Asp Gly Gln Val Phe Gln Lys Ala Val Glu Tyr Ser 
65                  70                  75                  80  


Asp Val Asp Leu Thr Phe Tyr Asp Leu Ser Gly Ser Ser Asp Pro Glu 
                85                  90                  95      


Arg Glu Val Arg Glu Met Thr Ala Ser Ile Gln Arg Thr Pro Met Pro 
            100                 105                 110         


Leu Thr Gly Pro Met Ile Lys Phe Ala Leu Phe Arg Thr Gly Ser Ala 
        115                 120                 125             


Glu Tyr Tyr Trp Phe Thr Thr Cys His His Ile Ala Ile Asp Gly Met 
    130                 135                 140                 


Gly Ile Ala Leu Val Gly Arg Arg Ile Ala Ala Val Tyr Thr Ala Leu 
145                 150                 155                 160 


Ala Ser Gly Lys Pro Ile Pro Pro Ala Phe Phe Gly Ser Leu Gln Asp 
                165                 170                 175     


Leu Val Gly Gly Glu Leu Glu Tyr Glu Ala Ser Ala Lys Phe Leu Glu 
            180                 185                 190         


Asp Lys Asp Tyr Trp Leu Ala His Arg Pro Gly Asp Gly Thr Ala Gly 
        195                 200                 205             


His Pro Pro Arg Pro Ala Asp Asp Gly Arg Asp Pro Tyr Ser Pro Ser 
    210                 215                 220                 


Pro Pro Val Gln Leu Asp Glu Ser Val Ile Gly Ser Val Lys Glu Leu 
225                 230                 235                 240 


Ser Lys Ala Leu Gly Ile Arg Arg Ser Ser Val Leu Thr Ala Ala Cys 
                245                 250                 255     


Ala Leu Leu Val Arg Gly Trp Cys Ala Asp Gly Ser Asp Glu Val Val 
            260                 265                 270         


Leu Asp Phe Pro Val Ser Arg Arg Val Asp Pro Lys Ser Lys Thr His 
        275                 280                 285             


Pro Gly Met Leu Ala Gly Val Val Pro Leu Val Leu His Ala Pro Ala 
    290                 295                 300                 


Ala Ala Thr Phe Ala Asp Phe Cys Arg His Val Asp Gln Arg Ser Arg 
305                 310                 315                 320 


Glu Ala Leu Arg His Gln Gln Phe Pro Thr Arg Thr Leu Asp Gly Glu 
                325                 330                 335     


Gly Asp Phe Ser Gly Pro Arg Gln Ala Pro Asn Arg Val Val Val Asn 
            340                 345                 350         


Phe Val Pro Ala Arg Leu Thr Leu Ser Leu Ala Asp Val Pro Ala Thr 
        355                 360                 365             


Ala Thr Tyr Thr Ser Phe Gly Pro Val Gly His Phe Gly Leu Phe Phe 
    370                 375                 380                 


Leu Gly Phe Gly Asp Gln Gln Phe Leu Ser Thr Val Gly Thr Gly Gln 
385                 390                 395                 400 


Pro Leu Ala Asn Phe Asp Ala Thr Asp Leu Ala Glu Arg Leu Gln Arg 
                405                 410                 415     


Ile Leu Ala Ala Met Ala Ala Asp Pro Ala Arg Leu Leu Ser Ser Leu 
            420                 425                 430         


Asp Val Leu Arg Asp Pro Glu His Ala Gln Leu Glu Ala Leu Gly Asn 
        435                 440                 445             


Thr Ala Val Leu Thr Arg Thr Pro Gly Pro Ala Val Ser Val Pro Glu 
    450                 455                 460                 


Leu Phe Ala Thr Gln Val Ala Arg Ala Pro Gln Asp Val Ala Leu Val 
465                 470                 475                 480 


Cys Glu Gly Arg Ser Leu Thr Tyr Arg Gln Leu Asp Glu Ala Ser Asn 
                485                 490                 495     


Arg Leu Ala His Leu Leu Ala Gly Leu Gly Ala Gly Pro Gly Gln Ser 
            500                 505                 510         


Val Ala Leu Leu Phe Ser Arg Ser Ala Glu Ala Val Ala Ser Ile Leu 
        515                 520                 525             


Ala Val Leu Lys Thr Gly Ala Ala Tyr Leu Pro Ile Asp Pro Ala Ala 
    530                 535                 540                 


Pro Glu Thr Arg Ile Gly Phe Met Leu Ala Asp Ala Lys Pro Val Ala 
545                 550                 555                 560 


Ala Leu Ser Thr Ala Glu Leu Ala Gly Arg Leu Glu Gly His Gly Met 
                565                 570                 575     


Thr Val Ile Asp Val Asn Asp Pro Arg Ile Gln Asp Arg Pro Ala Thr 
            580                 585                 590         


Ala Leu Pro Val Pro Ala Ala Asp Gly Val Ala Tyr Val Ile Tyr Thr 
        595                 600                 605             


Ser Gly Thr Thr Gly Val Pro Lys Gly Val Ala Val Thr His Arg Asn 
    610                 615                 620                 


Val Thr Gln Leu Leu Gly Ser Leu Asp Ala Gly Leu Pro Pro Ala Gly 
625                 630                 635                 640 


Val Trp Ser Gln Cys His Ser Tyr Ala Phe Asp Val Ser Val Trp Glu 
                645                 650                 655     


Ile Phe Gly Ala Leu Leu Arg Gly Gly Arg Leu Val Val Val Pro Glu 
            660                 665                 670         


Asp Val Thr Arg Ala Pro Glu Glu Leu His Asp Val Leu Val Asn Glu 
        675                 680                 685             


Gln Val Ser Val Leu Thr Gln Thr Pro Ser Ala Val Ala Met Leu Ser 
    690                 695                 700                 


Pro Gln Gly Leu Glu Ser Val Ser Leu Val Val Val Gly Glu Ala Cys 
705                 710                 715                 720 


Pro Ala Glu Val Val Asp Arg Trp Ser Pro Gly Arg Val Met Val Asn 
                725                 730                 735     


Ala Tyr Gly Pro Thr Glu Thr Thr Met Cys Val Ala Ile Ser Ala Pro 
            740                 745                 750         


Leu Ala Pro Gly Met Gly Ser Pro Pro Ile Gly Val Pro Val Asp Gly 
        755                 760                 765             


Ala Gly Leu Phe Val Leu Asp Ala Trp Leu Arg Pro Val Pro Pro Gly 
    770                 775                 780                 


Val Val Gly Glu Leu Tyr Val Gly Gly Ala Gly Val Ala Cys Gly Tyr 
785                 790                 795                 800 


Trp Arg Arg Gly Gly Leu Thr Ala Ser Trp Phe Val Ala Cys Pro Phe 
                805                 810                 815     


Gly Ala Pro Gly Ala Arg Met Tyr Arg Thr Gly Asp Leu Val Cys Trp 
            820                 825                 830         


Arg Ser Asp Gly Gln Leu Asp Tyr Arg Gly Arg Ala Asp Glu Gln Val 
        835                 840                 845             


Lys Val Arg Gly Tyr Arg Ile Glu Leu Gly Glu Val Gln Ala Ala Leu 
    850                 855                 860                 


Ala Ala Leu Asp Asp Val Asp Gln Ala Val Val Ile Ala Arg Glu Asp 
865                 870                 875                 880 


Arg Pro Gly Gly Lys Arg Leu Val Gly Tyr Ile Thr Gly Thr Ala Asp 
                885                 890                 895     


Pro Ala Glu Val Arg Thr Ala Leu Ala Gln Arg Leu Pro Val Tyr Met 
            900                 905                 910         


Val Pro Ala Ala Val Val Ala Leu Asp Ala Ile Pro Leu Thr Pro Asn 
        915                 920                 925             


Gly Lys Leu Asp Thr Arg Ala Leu Pro Thr Pro Glu Tyr Thr Gly Ser 
    930                 935                 940                 


Arg Tyr Arg Ala Pro Ser Asn Ala Val Glu Glu Thr Val Ala Gly Ile 
945                 950                 955                 960 


Tyr Ala His Val Leu Gly Val Glu Arg Val Gly Val Asp Asp Ser Phe 
                965                 970                 975     


Phe Asp Leu Gly Gly Asp Ser Ile Ser Ala Leu Gln Val Val Ala Arg 
            980                 985                 990         


Ala Arg Ala Ala Gly Leu Thr Cys  Arg Pro Arg Asp Val  Phe Val Glu 
        995                 1000                 1005             


Gln Thr  Val Ala Arg Leu Ala  Arg Val Val Gly Ser  Gly Asp Arg 
    1010                 1015                 1020             


Ala Ala  Glu Val Ala Asp Glu  Gly Val Gly Pro Val  Pro Pro Thr 
    1025                 1030                 1035             


Pro Ile  Met Arg Trp Leu Gln  Ala Ala Glu Arg Ala  Gly Gly Ala 
    1040                 1045                 1050             


Thr Asp  Gln Phe Asn Gln Thr  Val Leu Val Gln Ala  Pro Ala Gly 
    1055                 1060                 1065             


Val Thr  Glu Thr Glu Val Ala  Ile Val Leu Gln Ala  Leu Val Asp 
    1070                 1075                 1080             


Arg His  Ala Met Leu Arg Leu  Arg Val Thr Asp Asp  Gly Ala Asp 
    1085                 1090                 1095             


Gly Trp  Ser Phe Glu Val Pro  Glu Ala Gly Ser Val  Gln Ala Arg 
    1100                 1105                 1110             


Asp Cys  Leu Arg Ser Val Asp  Ala Leu Ser Asp Glu  Ala Leu Leu 
    1115                 1120                 1125             


Ala Ala  Arg Ala Arg Leu Asn  Pro Ala Ala Gly Thr  Met Leu Ala 
    1130                 1135                 1140             


Ala Leu  Trp Val Glu Ala Thr  Gly Gln Leu Ala Val  Ile Ile His 
    1145                 1150                 1155             


His Leu  Ala Val Asp Ala Val  Ser Trp Trp Ile Leu  Leu Glu Asp 
    1160                 1165                 1170             


Leu Asn  Ile Ala Trp Ala Leu  His Arg Ala Gly Gln  Pro Val Glu 
    1175                 1180                 1185             


Leu Ala  Pro Ala Gly Thr Ser  Phe Ala Arg Trp Ala  Arg Leu Leu 
    1190                 1195                 1200             


Asp Glu  His Ala Arg Asp Pro  Glu Val Val Gly Gln  Leu Asp Arg 
    1205                 1210                 1215             


Trp Lys  Thr Val Thr Ser Thr  Pro Ala Ala Leu Pro  Ala Pro Arg 
    1220                 1225                 1230             


Pro Asp  Val Asp Thr Tyr Ala  Ser Ala Gly Arg Leu  Ser Val Glu 
    1235                 1240                 1245             


Leu Asp  Ala Glu Thr Thr Ala  Met Leu Leu Gly Glu  Val Pro Ala 
    1250                 1255                 1260             


Ala Phe  His Ala Gly Ile His  Asp Ile Leu Leu Ile  Ala Phe Gly 
    1265                 1270                 1275             


Leu Ala  Trp Thr Glu Phe Leu  Gly Glu Pro Gly Ala  Pro Ile Gly 
    1280                 1285                 1290             


Ile Asp  Val Glu Gly His Gly  Arg His Glu Glu Leu  Gly Ala Asp 
    1295                 1300                 1305             


Ile Asp  Leu Ser Arg Thr Val  Gly Trp Phe Thr Ala  Lys Tyr Pro 
    1310                 1315                 1320             


Val Ser  Leu Asp Val Ala Gly  Leu Arg Trp Pro Gln  Val Ala Ala 
    1325                 1330                 1335             


Gly Asp  Pro Ala Leu Gly Pro  Val Leu Lys Arg Ala  Lys Glu Gln 
    1340                 1345                 1350             


Leu Arg  Thr Leu Pro Glu Pro  Leu Thr Tyr Gly Leu  Leu Arg Tyr 
    1355                 1360                 1365             


Leu Asn  Thr Asp Val Asp Leu  Ala Gly Ala Asp Pro  Pro Ile Ala 
    1370                 1375                 1380             


Phe Asn  Tyr Leu Gly Arg Gln  Gly Ala Ala Ser Asp  Ser Ala Ala 
    1385                 1390                 1395             


Asp Gly  Trp Arg Ile Ser Gln  Asp Met Ser Leu Leu  Gly Ala Ala 
    1400                 1405                 1410             


Ala Ala  Val Pro Met Pro Leu  Met His Ala Val Glu  Leu Asn Ala 
    1415                 1420                 1425             


Gly Thr  Ile Asp Thr Gly Ala  Gly Pro His Leu His  Ala Glu Trp 
    1430                 1435                 1440             


Thr Trp  Ala Pro Ser Val Leu  Gly Ala Glu Gln Ile  Thr Arg Val 
    1445                 1450                 1455             


Ser Arg  Leu Trp Phe Glu Ala  Leu Ala Gly Val Cys  Ala His Val 
    1460                 1465                 1470             


Arg Ser  Gly Gly Gly Gly Gly  Leu Thr Pro Ser Asp  Ile Ala Pro 
    1475                 1480                 1485             


Ala Arg  Leu Thr Gln Gln Gln  Ile Asp Glu Leu Gln  Ser Arg His 
    1490                 1495                 1500             


Arg Ile  Ala Asp Ile Leu Pro  Leu Thr Pro Leu Gln  Gln Gly Leu 
    1505                 1510                 1515             


Leu Phe  His Ser Ser Thr Ala  Gln Gly Asn Asp Gly  Met Asp Asp 
    1520                 1525                 1530             


Met Tyr  Ala Val Gln Leu Asp  Phe Thr Leu Thr Gly  Pro Leu Asp 
    1535                 1540                 1545             


Ala Asp  Arg Leu Arg Glu Ala  Val Arg Thr Val Val  His Arg His 
    1550                 1555                 1560             


Pro His  Leu Ala Ala Leu Phe  Cys Asp Gln Tyr Asp  Glu Pro Val 
    1565                 1570                 1575             


Gln Ile  Ile Pro Ala Asp Pro  Ala Val Glu Trp Arg  Tyr Val Glu 
    1580                 1585                 1590             


Leu Asp  Gly Thr Gly Ala Ala  Asp Ala Asp Asp Leu  Ile Glu Gln 
    1595                 1600                 1605             


Leu Cys  Ala Ala Glu Arg Ala  Ala Val Ala Asp Leu  Ala Gly Gln 
    1610                 1615                 1620             


Pro Val  Phe Arg Thr Ala Leu  Val Arg Thr Gly Gly  Asp Arg His 
    1625                 1630                 1635             


Arg Phe  Val Leu Thr Ser His  His Ile Leu Leu Asp  Gly Trp Ser 
    1640                 1645                 1650             


Leu Pro  Ile Leu Leu Arg Glu  Ile Phe Ala Gly Tyr  Tyr Gly Gln 
    1655                 1660                 1665             


Arg Leu  Pro Ala Ala Gly Ser  Tyr Arg Ala Phe Leu  Thr Trp Leu 
    1670                 1675                 1680             


Ala Glu  Arg Asp Leu Asp Ala  Ala Arg Arg Ala Trp  Gly Glu Val 
    1685                 1690                 1695             


Leu Ser  Gly Phe Asp Thr Pro  Thr Leu Val Ala Pro  Glu Gly Arg 
    1700                 1705                 1710             


Leu Gly  Gln Gly Arg Arg Gly  Phe Glu Lys Ser Cys  Val Pro Glu 
    1715                 1720                 1725             


Gln Thr  Thr Arg Ala Leu Gly  Glu Leu Ala Arg Ser  Cys His Thr 
    1730                 1735                 1740             


Thr Leu  Ser Thr Val Leu Gln  Ala Ala Trp Ala Val  Val Leu Thr 
    1745                 1750                 1755             


Ser Leu  Thr Gly Arg His Asp  Val Val Phe Gly Thr  Pro Arg Ser 
    1760                 1765                 1770             


Arg Val  Gly Gln Leu Glu Val  Asp Asp Ala Glu Gln  Met Val Gly 
    1775                 1780                 1785             


Leu Leu  Ile Asn Thr Val Pro  Val Arg Ala Glu Ile  Thr Ala Thr 
    1790                 1795                 1800             


Thr Thr  Thr Ala Gln Leu Leu  Ala Gln Leu Gln Asn  Ser His Asn 
    1805                 1810                 1815             


Asp Thr  Leu Glu His Gln His  Leu Ala Leu Asn Glu  Ile His Arg 
    1820                 1825                 1830             


Val Thr  Gly His Asp Gln Leu  Phe Asp Thr Leu Phe  Val Tyr Glu 
    1835                 1840                 1845             


Asn Tyr  Pro Ile Asp Ser Gly  Met Thr Leu Gly Ala  Asp Gly Leu 
    1850                 1855                 1860             


Ala Ile  Ala Glu Phe Thr Asn  Arg Glu Tyr Asn His  Tyr Pro Leu 
    1865                 1870                 1875             


Thr Val  Glu Ala Leu Pro Gly  Pro Glu Leu Gly Leu  His Ile Glu 
    1880                 1885                 1890             


Phe Asp  Thr Asp Val Phe Asp  Thr Ala Ser Ile Glu  Ser Leu Val 
    1895                 1900                 1905             


Gln Arg  Leu Gln Arg Val Leu  Val Ala Met Ser Thr  Asp Pro Asp 
    1910                 1915                 1920             


Arg Arg  Leu Ser Ser Leu Asp  Leu Leu Asp Arg Gly  Glu Arg Glu 
    1925                 1930                 1935             


Leu Val  Leu Ser Thr Met Ser  Gly Ala Gly Val Ser  Ala Pro Ile 
    1940                 1945                 1950             


Gly Val  Ala Pro Gln Leu Leu  Ala Ala Ala Val Ala  Ala Asp Pro 
    1955                 1960                 1965             


Asp Ala  Pro Ala Ile Val Asp  Gly Ala Arg Glu Leu  Ser Tyr Arg 
    1970                 1975                 1980             


Glu Leu  Asp Asp Trp Ser Thr  Arg Leu Ala Arg Lys  Leu Ile Gln 
    1985                 1990                 1995             


His Gly  Val Gly Pro Glu His  Ala Ala Gly Val Ala  Ile Glu Arg 
    2000                 2005                 2010             


Cys Ala  Glu Leu Val Val Ala  Trp Trp Ala Val Thr  Lys Val Gly 
    2015                 2020                 2025             


Gly Val  Tyr Ala Pro Val Asn  Leu Asp His Pro Val  Glu Arg Ile 
    2030                 2035                 2040             


Ala Ser  Val Leu Asp Thr Val  Asn Ala Val Cys Val  Leu Thr Cys 
    2045                 2050                 2055             


Gly Thr  Asp Glu Val Ala Gly  Ala Gly Pro Arg Pro  Ile Leu Arg 
    2060                 2065                 2070             


Ile Asp  Gly Leu Asp Leu Ser  Gly His Ser Thr Glu  Pro Ile Thr 
    2075                 2080                 2085             


Asp Ala  Asp Arg Arg Ser Pro  Leu Arg Ala Asp Asp  Thr Ala Tyr 
    2090                 2095                 2100             


Leu Ile  Phe Thr Ser Gly Ser  Thr Gly Val Pro Lys  Gly Val Ala 
    2105                 2110                 2115             


Val Ser  His Thr Gly Leu Leu  Gly Trp Ala Ala Ala  Gln Arg Glu 
    2120                 2125                 2130             


Leu Phe  Gly Leu Gly Ala Asp  Ala Arg Val Leu Met  Val Ala Ser 
    2135                 2140                 2145             


Pro Thr  Phe Asp Ala Ser Val  Gly Glu Leu Leu Leu  Ala Ala Gly 
    2150                 2155                 2160             


Ser Gly  Ala Ala Leu Ile Val  Ala Pro Pro Gln Val  Tyr Ala Gly 
    2165                 2170                 2175             


Glu Ala  Leu Thr Ala Leu Leu  His Asn Gln Arg Val  Gly Thr Ala 
    2180                 2185                 2190             


Ile Leu  Thr Pro Thr Val Ile  Ser Thr Leu Asp Arg  Gly Arg Leu 
    2195                 2200                 2205             


Asp Gly  Leu His Thr Leu Val  Ala Val Gly Glu Ala  Cys Leu Pro 
    2210                 2215                 2220             


Glu Leu  Val Asp Gly Trp Ala  Pro Gly Arg Gln Met  Phe Asn Gly 
    2225                 2230                 2235             


Tyr Gly  Pro Ser Glu Thr Thr  Ile Trp Val Thr Cys  Ala Arg Leu 
    2240                 2245                 2250             


Thr Ala  Gly His Pro Val Arg  Ile Gly Ala Pro Ile  Pro Gly Val 
    2255                 2260                 2265             


Cys Ala  Arg Val Leu Asp Gly  Trp Leu Lys Pro Val  Pro Val Gly 
    2270                 2275                 2280             


Val Val  Gly Glu Leu Tyr Leu  Ser Gly Pro Ala Leu  Gly His Gly 
    2285                 2290                 2295             


Tyr Leu  Gly Arg Val Asp Leu  Thr Ala Glu Arg Phe  Val Ala Asn 
    2300                 2305                 2310             


Pro Phe  Gly Gly Pro Gly Glu  Arg Met Tyr Arg Thr  Gly Asp Leu 
    2315                 2320                 2325             


Val Arg  Trp Thr Pro Glu Gly  Thr Leu Asp Tyr Leu  Gly Arg Ala 
    2330                 2335                 2340             


Asp Asn  Gln Ile Lys Leu Arg  Gly Gln Arg Ile Glu  Leu Gly Glu 
    2345                 2350                 2355             


Ile Glu  Asn Thr Leu Leu Ala  Cys Pro Gln Val Thr  Gln Ala Ala 
    2360                 2365                 2370             


Val Thr  Val Gln Asp Ser Ala  Ala Gly Ser Gln Leu  Val Ala Tyr 
    2375                 2380                 2385             


Val Thr  Leu Asp His Gly Pro  Ser Asp Ala Asp Val  Arg His Asp 
    2390                 2395                 2400             


Thr Asp  Asp Ala Asp Asp Val  Ala Gln Trp Arg His  Leu Tyr Asp 
    2405                 2410                 2415             


Asp Leu  Tyr Gly Ala Asp Leu  Ala Ala Thr Phe Gly  Glu Asp Phe 
    2420                 2425                 2430             


Arg Gly  Trp Asn Ser Ser Tyr  Thr Gly Glu Pro Ile  Pro Leu Gln 
    2435                 2440                 2445             


Glu Met  Ala Glu Trp Arg Ser  Ala Thr Val Asp Arg  Ile Met Ser 
    2450                 2455                 2460             


Leu Arg  Pro Arg Arg Val Leu  Glu Ile Gly Ala Gly  Ser Gly Leu 
    2465                 2470                 2475             


Leu Leu  Ser Gln Ile Ala Pro  Arg Cys Asp Arg Tyr  Val Ala Thr 
    2480                 2485                 2490             


Asp Phe  Ser Ala Val Ala Ile  Asp Asn Leu Ala Arg  Ser Met Glu 
    2495                 2500                 2505             


Gln Leu  Gln Leu Pro Trp Arg  Asp Arg Val Glu Leu  Leu Thr Gln 
    2510                 2515                 2520             


Pro Ala  His Val Thr Asp Gly  Leu Pro Pro Gly His  Phe Asp Thr 
    2525                 2530                 2535             


Ile Val  Ile Asn Ser Val Val  Gln Tyr Phe Pro Asn  Ala Gly Tyr 
    2540                 2545                 2550             


Leu Ala  Asp Val Ile Asp Asn  Ala Leu Glu Leu Leu  Ala Pro Gly 
    2555                 2560                 2565             


Gly Ser  Leu Phe Ile Gly Asp  Val Arg Asn His Ala  Leu Gln Gly 
    2570                 2575                 2580             


Ala Phe  Gln Thr Gly Ile Ala  Leu Ala Arg Gly Gly  Gly Ala Asp 
    2585                 2590                 2595             


Ala Ala  Glu Ile Arg Gln Arg  Val Arg His Ala Met  Leu Gly Glu 
    2600                 2605                 2610             


Thr Glu  Leu Leu Leu Ala Pro  Glu Phe Phe Thr Asn  Trp Ala Asp 
    2615                 2620                 2625             


Ser Arg  Pro Ala Ala Ala Gly  Leu Asp Ile Gln Leu  Lys Arg Gly 
    2630                 2635                 2640             


Leu Ser  Asp Asn Glu Leu Asn  Arg Tyr Arg Tyr Asp  Val Val Ile 
    2645                 2650                 2655             


His Lys  Ala Pro Ala Pro Val  Arg Ser Val Ala Ala  Ala Pro Thr 
    2660                 2665                 2670             


Trp Ser  Trp Thr Asp Cys Thr  Asp Cys Ala Gly Leu  Arg Asp Gln 
    2675                 2680                 2685             


Leu Ala  Ala Arg Arg Pro Ala  Val Val Arg Val Thr  Asp Ile Pro 
    2690                 2695                 2700             


Gln Ala  Gly Val Ile Asp Asp  Val Arg Val Glu Ala  Ala Leu Ala 
    2705                 2710                 2715             


Ala Gly  Leu Pro Val Ala Asp  Ala Leu Ala Ala Ala  Gly Ser Asp 
    2720                 2725                 2730             


Thr Ala  Ala Ala Val Ala Glu  Glu Leu His Arg Val  Gly Glu Ala 
    2735                 2740                 2745             


Thr Gly  Tyr Arg Val Ala Val  Thr Trp Gly Ala Gln  Pro Gly Thr 
    2750                 2755                 2760             


Leu Ser  Ala Val Phe Val Gln  Asp Gly Asp Gln Ala  Ala Glu Pro 
    2765                 2770                 2775             


Leu Thr  Asp Leu Tyr Leu Pro  Pro Ala Gly Ala Arg  Gln Arg Thr 
    2780                 2785                 2790             


Arg His  Ala Asn Asp Pro Arg  Ala Asn Thr Lys Ile  Ala Gln Val 
    2795                 2800                 2805             


Arg Glu  Arg Leu Asn Ala Trp  Leu Pro Glu Tyr Met  Val Pro Thr 
    2810                 2815                 2820             


His Ile  Val Ala Leu Asp Glu  Phe Pro Met Thr Thr  Ser Gly Lys 
    2825                 2830                 2835             


Leu Asp  Arg Lys Ala Leu Pro  Ala Pro Asp Tyr Gln  Asp Ala Asp 
    2840                 2845                 2850             


Arg Tyr  Arg Ala Pro Ser Thr  Ala Val Glu Glu Ile  Leu Val Gly 
    2855                 2860                 2865             


Ile Tyr  Gly Gln Val Leu Gly  Leu Glu Arg Val Gly  Val Asp Asp 
    2870                 2875                 2880             


Ser Phe  Phe Asp Leu Gly Gly  Asp Ser Leu Ser Ala  Met Arg Leu 
    2885                 2890                 2895             


Ile Ala  Ala Val Asn Ala Ser  Leu Asn Thr Asp Leu  Gly Val Arg 
    2900                 2905                 2910             


Thr Val  Phe Glu Ala Pro Thr  Ala Ala Glu Leu Ala  Leu Arg Val 
    2915                 2920                 2925             


Gly Ser  Glu Ala Asp Arg Pro  Glu Pro Leu Val Ala  Gly Glu Arg 
    2930                 2935                 2940             


Pro Ala  Val Ile Pro Leu Ser  Phe Ala Gln Thr Arg  Leu Trp Phe 
    2945                 2950                 2955             


Ile Asp  Gln Phe Gln Gly Pro  Ser Pro Met Tyr Asn  Ile Thr Val 
    2960                 2965                 2970             


Ala Leu  Arg Leu Ser Gly Arg  Leu Asp Ala Asp Ala  Leu Arg Ala 
    2975                 2980                 2985             


Ala Leu  Ala Asp Val Val Ala  Arg His Glu Ser Leu  Arg Thr Val 
    2990                 2995                 3000             


Phe Ala  Thr Ala Asp Gly Thr  Pro Gln Gln Val Val  Ile Pro Ala 
    3005                 3010                 3015             


Asp Arg  Ile Gly Phe Ala Cys  Asp Val Val Asp Ala  Arg Gly Trp 
    3020                 3025                 3030             


Pro Glu  Asp Arg Leu Arg Glu  Ala Met Ser Ala Ala  Ala Arg Tyr 
    3035                 3040                 3045             


Thr Phe  Asp Leu Ser Ala Glu  Ser Pro Leu His Thr  Glu Leu Phe 
    3050                 3055                 3060             


Ala Arg  Gly Asp Asp Glu His  Val Leu Val Val Ala  Val His His 
    3065                 3070                 3075             


Ile Ala  Ala Asp Gly Trp Ser  Ile Thr Pro Phe Ala  Arg Asp Leu 
    3080                 3085                 3090             


Gly Val  Ala Tyr Ala Ser Arg  Cys Ala Gly Arg Asp  Pro Asp Trp 
    3095                 3100                 3105             


Ala Pro  Leu Pro Val Gln Tyr  Ala Asp Tyr Thr Leu  Trp Gln Arg 
    3110                 3115                 3120             


Ala His  Leu Gly Asp Val Asp  Asp Pro Gly Ser Arg  Ile Ala Ala 
    3125                 3130                 3135             


Gln Leu  Asp Phe Trp Thr Asp  Ala Leu Ala Gly Leu  Pro Glu Arg 
    3140                 3145                 3150             


Leu Gln  Leu Pro Thr Asp Arg  Pro Tyr Pro Ala Val  Ala Asp His 
    3155                 3160                 3165             


Arg Gly  Ala Arg Leu Ala Val  Asp Trp Pro Ala Glu  Leu Gln Gln 
    3170                 3175                 3180             


Arg Ile  Gly Asp Val Ala His  Arg His Asn Ala Thr  Ser Phe Met 
    3185                 3190                 3195             


Val Ile  Gln Thr Ala Leu Thr  Val Leu Leu Ala Lys  Leu Gly Ala 
    3200                 3205                 3210             


Asn Pro  Asp Val Ala Val Gly  Phe Pro Ile Ala Gly  Arg Arg Asp 
    3215                 3220                 3225             


Pro Ala  Leu Asp Asp Leu Val  Gly Phe Phe Val Asn  Thr Leu Val 
    3230                 3235                 3240             


Leu Arg  Val Asp Ala Ala Gly  Asp Pro Ser Phe Thr  Glu Leu Leu 
    3245                 3250                 3255             


Ala Arg  Val Arg Thr Arg Ser  Leu Glu Ala Phe Glu  His Gln Asp 
    3260                 3265                 3270             


Val Pro  Phe Glu Val Leu Val  Glu Arg Leu Asn Pro  Thr Arg Ser 
    3275                 3280                 3285             


Leu Thr  His His Pro Leu Val  Gln Val Met Leu Ala  Trp Gln Asn 
    3290                 3295                 3300             


Phe Ala  Gly Gln Asp Thr Gly  Pro Ala Ala Gly Leu  Ser Leu Gly 
    3305                 3310                 3315             


Asp Val  Glu Ile Thr Pro Ile  Pro Val Asp Thr His  Thr Ala Arg 
    3320                 3325                 3330             


Met Asp  Leu Thr Phe Ser Val  Gly Glu Arg Trp Cys  Glu Ser Gly 
    3335                 3340                 3345             


Glu Pro  Gly Gly Ile Gly Gly  Thr Val Glu Phe Arg  Thr Asp Val 
    3350                 3355                 3360             


Phe Asp  Pro Asp Ser Ile Gln  Thr Leu Ile Gly Arg  Leu Arg Arg 
    3365                 3370                 3375             


Val Leu  Glu Ala Met Thr Asp  Asp Pro Thr Gln Ser  Val Trp Ser 
    3380                 3385                 3390             


Val Asp  Leu Leu Asp Ala Gly  Glu His Ala Arg Leu  Asp Thr Leu 
    3395                 3400                 3405             


Gly Asn  Arg Ala Ala Leu Thr  Gly Pro Pro Pro Arg  Phe Asp Ser 
    3410                 3415                 3420             


Leu Pro  Thr Leu Phe Ala Glu  Gln Ala Ala Arg Thr  Pro Asp Ala 
    3425                 3430                 3435             


Val Ala  Leu Val Cys Gly Gly  Arg Arg Met Thr Tyr  Arg Glu Leu 
    3440                 3445                 3450             


Asp Glu  Ala Ala Asn Arg Val  Ala His Leu Leu Arg  Val Arg Gly 
    3455                 3460                 3465             


Ala Gly  Pro Gly His Thr Val  Ala Leu Leu Phe Ser  Arg Ser Ala 
    3470                 3475                 3480             


Glu Ala  Ile Val Ala Ile Leu  Gly Val Leu Lys Ser  Gly Ala Ala 
    3485                 3490                 3495             


Tyr Leu  Pro Ile Asp Pro Ala  Leu Pro Gly Glu Arg  Ile Gly Phe 
    3500                 3505                 3510             


Met Leu  Ala Asp Ala Ala Pro  Met Val Ala Ile Ser  Thr Ala Glu 
    3515                 3520                 3525             


Leu Ala  Pro Arg Leu His Gly  Gln His Asp Val Pro  Val Ile Asp 
    3530                 3535                 3540             


Val His  Asp Pro Ala Ile Glu  Ala Ala Pro Ser Ser  Ala Leu Pro 
    3545                 3550                 3555             


Pro Pro  Gly Ala Asp Asp Ile  Ala Tyr Leu Ile Tyr  Thr Ser Gly 
    3560                 3565                 3570             


Thr Thr  Gly Val Pro Lys Gly  Val Ala Val Ser His  Arg Asn Val 
    3575                 3580                 3585             


Thr Gln  Leu Leu Thr Ala Asp  Ser Gly Leu Pro Arg  Glu Gly Val 
    3590                 3595                 3600             


Trp Ser  Gln Trp His Ser Leu  Ala Phe Asp Val Ser  Val Trp Glu 
    3605                 3610                 3615             


Ile Phe  Gly Ala Leu Leu His  Gly Gly Arg Leu Val  Val Ile Pro 
    3620                 3625                 3630             


Asp Ser  Val Val Arg Ser Pro  Asp Asp Phe His Ala  Leu Leu Leu 
    3635                 3640                 3645             


Asp Glu  Gln Val Ser Val Leu  Ser Gln Thr Pro Ser  Ala Ala Gly 
    3650                 3655                 3660             


Thr Leu  Ser Pro Glu Gly Leu  Glu Asp Leu Thr Leu  Val Val Ala 
    3665                 3670                 3675             


Gly Glu  Ala Cys Pro Ala Glu  Leu Val Asp Arg Trp  Ala Pro Gly 
    3680                 3685                 3690             


Arg Thr  Met Ile Asn Ala Tyr  Gly Pro Thr Glu Ala  Thr Val Tyr 
    3695                 3700                 3705             


Thr Ala  Ile Ser Ala Pro Leu  Gln Pro Gly Ser Pro  Ala Gly Val 
    3710                 3715                 3720             


Pro Ile  Gly Phe Pro Val Pro  Gly Ala Gly Leu Phe  Val Leu Asp 
    3725                 3730                 3735             


Glu Ser  Leu Arg Pro Val Pro  Pro Gly Val Val Gly  Glu Leu Tyr 
    3740                 3745                 3750             


Val Gly  Gly Ala Gly Val Ala  Cys Gly Tyr Trp Arg  Arg Gly Gly 
    3755                 3760                 3765             


Leu Thr  Ala Ser Trp Phe Val  Ala Cys Pro Phe Gly  Ala Pro Gly 
    3770                 3775                 3780             


Ala Arg  Met Tyr Arg Thr Gly  Asp Leu Val Cys Trp  Arg Ser Asp 
    3785                 3790                 3795             


Gly Gln  Leu Asp Tyr Arg Gly  Arg Ala Asp Glu Gln  Val Lys Val 
    3800                 3805                 3810             


Arg Gly  Tyr Arg Ile Glu Leu  Gly Glu Val Gln Ala  Ala Leu Ala 
    3815                 3820                 3825             


Gly Leu  Asp Asp Val Glu Gln  Ala Val Val Ile Ala  Arg Glu Asp 
    3830                 3835                 3840             


Arg Pro  Gly Gly Lys Arg Leu  Val Gly Tyr Ile Thr  Gly Thr Ala 
    3845                 3850                 3855             


Asp Pro  Ala Glu Val Arg Thr  Ala Leu Ala Gln Arg  Leu Pro Val 
    3860                 3865                 3870             


Tyr Met  Val Pro Ala Ala Val  Val Ala Leu Asp Ala  Ile Pro Leu 
    3875                 3880                 3885             


Thr Pro  Asn Gly Lys Leu Asp  Thr Arg Ala Leu Pro  Thr Pro Glu 
    3890                 3895                 3900             


Tyr Thr  Gly Ser Arg Tyr Arg  Ala Pro Ser Asn Ala  Val Glu Glu 
    3905                 3910                 3915             


Thr Val  Ala Gly Ile Tyr Ala  His Val Leu Gly Val  Glu Arg Val 
    3920                 3925                 3930             


Gly Val  Asp Asp Ser Phe Phe  Asp Leu Gly Gly Asp  Ser Ile Ser 
    3935                 3940                 3945             


Ala Met  Arg Val Ile Thr Ala  Ile Asn Ala Ser Leu  Gly Val Glu 
    3950                 3955                 3960             


Leu Ala  Val Arg Thr Leu Phe  Glu Ala Pro Thr Val  Ala Ser Leu 
    3965                 3970                 3975             


Ser Trp  Arg Ala Gln Thr Asp  Thr Ala Arg Gly Gly  Gln Ala Glu 
    3980                 3985                 3990             


Glu Ile  Val Pro Val Gln Thr  Leu Lys Glu Gly Thr  Gly Ala Pro 
    3995                 4000                 4005             


Leu Phe  Cys Ile His Ala Ala  Gly Gly Leu Ser Trp  Ser Tyr Gln 
    4010                 4015                 4020             


Val Leu  Gly Asn His Leu Asp  Cys Pro Ile Ile Gly  Ile Gln Gln 
    4025                 4030                 4035             


Ala Glu  Pro Gln His Ala Ala  Pro Arg Ser Ile Arg  Glu Met Ala 
    4040                 4045                 4050             


Gln Ser  Tyr Ala Asp Arg Ile  Gln Glu Thr Tyr Pro  Asp Gly Pro 
    4055                 4060                 4065             


Tyr His  Leu Val Gly Trp Ser  Phe Gly Gly Val Val  Ala His Glu 
    4070                 4075                 4080             


Leu Ala  Ile Glu Leu Gln Arg  Arg Gly Cys Ala Ile  Ala Arg Leu 
    4085                 4090                 4095             


Val Leu  Leu Asp Ala Gln Pro  Gly Leu Asp Gly Ser  Val Thr Ala 
    4100                 4105                 4110             


Pro Asp  Ala Ala Leu Ala Glu  Gln His Met Met Glu  Glu Ala Leu 
    4115                 4120                 4125             


Arg Ser  His Leu Ala Ala Ala  Asp His Asp Gln Pro  His Ala His 
    4130                 4135                 4140             


Arg Gln  Phe Asn Gln Leu Val  Arg Glu Ala Gly Ala  Glu Gly Met 
    4145                 4150                 4155             


Ser Arg  His Lys Arg Leu Phe  Asp Val Leu Phe Gly  Asn Ala Arg 
    4160                 4165                 4170             


Asn Asn  Ile Glu Arg Ser Lys  Ile His Glu Pro Gly  Val Phe Leu 
    4175                 4180                 4185             


Gly Asp  Val Thr Ile Phe Ser  Ala Val Arg Asp His  Glu Asp Arg 
    4190                 4195                 4200             


Ser Ala  Phe Leu Ala Glu Asn  Trp Arg Pro Tyr Val  Ala Gly Asp 
    4205                 4210                 4215             


Ile Val  Ile His Glu Ile Asp  Cys Thr His Asp Glu  Ile Leu Asn 
    4220                 4225                 4230             


Ala Asp  Val Val Asp Ser Tyr  Gly Gln Arg Leu Gly  Gln Leu Leu 
    4235                 4240                 4245             


Gly Ala  Gln Arg Arg Arg Glu  Leu Thr Pro Pro Gln  Arg Phe Gly 
    4250                 4255                 4260             


Ala Asp  Pro Gly Asp Asp Glu  Pro Pro Val Arg 
    4265                 4270                 


<210>  17
<211>  4273
<212>  PRT
<213>  Mycobacterium avium

<400>  17

Val Lys Arg Gly Asp Arg Ala Tyr Pro Val Thr Arg Gly Gln Leu Asp 
1               5                   10                  15      


Ile Trp Leu Ala Glu Gln Thr Gly His Leu Asp Val Ala Trp Gln Leu 
            20                  25                  30          


Gly Val Leu Val Arg Ile Asp Gly Ala Ile Asp Pro Ala Leu Leu His 
        35                  40                  45              


Gln Thr Met Arg His Val Val Gly Glu Ala Glu Ser Leu Arg Ala Ser 
    50                  55                  60                  


Phe Phe Glu Ala Asp Gly Gln Val Phe Gln Lys Ala Val Glu Tyr Ser 
65                  70                  75                  80  


Asp Val Asp Leu Thr Phe Tyr Asp Leu Ser Gly Ser Ser Asp Pro Glu 
                85                  90                  95      


Arg Glu Val Arg Glu Met Thr Ala Ser Ile Gln Arg Thr Pro Met Pro 
            100                 105                 110         


Leu Thr Gly Pro Met Thr Lys Phe Ala Leu Phe Arg Thr Gly Ser Ala 
        115                 120                 125             


Glu Tyr Tyr Trp Phe Thr Thr Cys His His Ile Ala Ile Asp Gly Met 
    130                 135                 140                 


Gly Ile Ala Leu Val Gly Arg Arg Ile Ala Ala Val Tyr Thr Ala Leu 
145                 150                 155                 160 


Ala Ser Gly Lys Pro Ile Pro Pro Ala Phe Phe Gly Ser Leu Gln Asp 
                165                 170                 175     


Leu Val Gly Gly Glu Leu Glu Tyr Glu Ala Ser Ala Lys Phe Leu Glu 
            180                 185                 190         


Asp Lys Asp Tyr Trp Leu Ala His Arg Pro Gly Asp Gly Thr Ala Gly 
        195                 200                 205             


His Pro Pro Arg Pro Ala Asp Asp Gly Arg Asp Pro Tyr Ser Pro Ser 
    210                 215                 220                 


Pro Pro Val Gln Leu Asp Glu Ser Val Ile Gly Ser Val Lys Glu Leu 
225                 230                 235                 240 


Ser Lys Ala Leu Gly Ile Arg Arg Ser Ser Val Leu Thr Ala Ala Cys 
                245                 250                 255     


Ala Leu Leu Val Arg Gly Trp Cys Ala Asp Gly Ser Asp Glu Val Val 
            260                 265                 270         


Leu Asp Phe Pro Val Ser Arg Arg Val Asp Pro Lys Ser Lys Thr His 
        275                 280                 285             


Pro Gly Met Leu Ala Gly Val Val Pro Leu Val Leu His Ala Pro Ala 
    290                 295                 300                 


Ala Ala Thr Phe Ala Asp Phe Cys Arg His Val Asp Gln Arg Ser Arg 
305                 310                 315                 320 


Glu Ala Leu Arg His Gln Gln Phe Pro Thr Arg Thr Leu Asp Gly Glu 
                325                 330                 335     


Gly Asp Phe Ser Gly Pro Arg Gln Ala Pro Asn Arg Val Val Val Asn 
            340                 345                 350         


Phe Val Pro Ala Arg Leu Thr Leu Ser Leu Ala Asp Val Pro Ala Thr 
        355                 360                 365             


Ala Thr Tyr Thr Ser Phe Gly Pro Val Gly His Phe Gly Leu Phe Phe 
    370                 375                 380                 


Leu Gly Phe Gly Asp Gln Gln Phe Leu Ser Thr Val Gly Thr Gly Gln 
385                 390                 395                 400 


Pro Leu Ala Asn Phe Asp Ala Thr Asp Leu Ala Glu Arg Leu Gln Arg 
                405                 410                 415     


Ile Leu Ala Ala Met Ala Ala Asp Pro Ala Arg Leu Leu Ser Ser Leu 
            420                 425                 430         


Asp Val Leu Arg Asp Pro Glu His Ala Gln Leu Glu Ala Leu Gly Asn 
        435                 440                 445             


Thr Ala Val Leu Thr Arg Thr Pro Gly Pro Ala Val Ser Val Pro Glu 
    450                 455                 460                 


Leu Phe Ala Thr Gln Val Ala Arg Ala Pro Gln Asp Val Ala Leu Val 
465                 470                 475                 480 


Cys Glu Gly Arg Ser Leu Thr Tyr Arg Gln Leu Asp Glu Ala Ser Asn 
                485                 490                 495     


Arg Leu Ala His Leu Leu Ala Gly Leu Gly Ala Gly Pro Gly Gln Ser 
            500                 505                 510         


Val Ala Leu Leu Phe Ser Arg Ser Ala Glu Ala Ile Val Ala Ile Leu 
        515                 520                 525             


Gly Val Leu Lys Ser Gly Ala Ala Tyr Leu Pro Ile Asp Pro Ala Leu 
    530                 535                 540                 


Pro Gly Glu Arg Ile Gly Phe Met Leu Ala Asp Ala Ala Pro Met Val 
545                 550                 555                 560 


Ala Ile Ser Thr Ala Glu Leu Ala Pro Arg Leu His Gly Gln His Asp 
                565                 570                 575     


Val Pro Val Ile Asp Val His Asp Pro Ala Ile Glu Ala Ala Pro Ser 
            580                 585                 590         


Ser Ala Leu Pro Pro Pro Gly Ala Asp Asp Ile Ala Tyr Leu Ile Tyr 
        595                 600                 605             


Thr Ser Gly Thr Thr Gly Val Pro Lys Gly Val Ala Val Ser His Arg 
    610                 615                 620                 


Asn Val Thr Gln Leu Leu Thr Ala Asp Ser Gly Leu Pro Arg Glu Gly 
625                 630                 635                 640 


Val Trp Ser Gln Trp His Ser Leu Ala Phe Asp Val Ser Val Trp Glu 
                645                 650                 655     


Ile Phe Gly Ala Leu Leu His Gly Gly Arg Leu Val Val Ile Pro Asp 
            660                 665                 670         


Ser Val Val Arg Ser Pro Asp Asp Phe His Ala Leu Leu Leu Asp Glu 
        675                 680                 685             


Gln Val Ser Val Leu Ser Gln Thr Pro Ser Ala Ala Gly Thr Leu Ser 
    690                 695                 700                 


Pro Glu Gly Leu Glu Asp Leu Thr Leu Val Val Ala Gly Glu Ala Cys 
705                 710                 715                 720 


Pro Ala Glu Leu Val Asp Arg Trp Ala Pro Gly Arg Thr Met Ile Asn 
                725                 730                 735     


Ala Tyr Gly Pro Thr Glu Thr Thr Met Cys Val Ala Ile Ser Ala Pro 
            740                 745                 750         


Leu Ala Pro Gly Met Gly Ser Pro Pro Ile Gly Val Pro Val Asp Gly 
        755                 760                 765             


Ala Gly Leu Phe Val Leu Asp Ala Trp Leu Arg Pro Val Pro Pro Gly 
    770                 775                 780                 


Val Val Gly Glu Leu Tyr Val Ala Gly Ala Gly Val Ala Cys Gly Tyr 
785                 790                 795                 800 


Trp Arg Arg Gly Gly Leu Thr Ala Ser Arg Phe Val Ala Cys Pro Phe 
                805                 810                 815     


Gly Ala Pro Gly Ala Arg Met Tyr Arg Thr Gly Asp Leu Val Cys Trp 
            820                 825                 830         


Arg Ser Asp Gly Gln Leu Asp Tyr Arg Gly Arg Ala Asp Glu Gln Val 
        835                 840                 845             


Lys Val Arg Gly Tyr Arg Ile Glu Leu Gly Glu Val Gln Ala Ala Leu 
    850                 855                 860                 


Ala Ala Leu Asp Asp Val Asp Gln Ala Val Val Ile Ala Arg Glu Asp 
865                 870                 875                 880 


Arg Pro Gly Gly Lys Arg Leu Val Gly Tyr Ile Thr Gly Thr Ala Asp 
                885                 890                 895     


Pro Ala Glu Val Arg Thr Ala Leu Ala Gln Arg Leu Pro Val Tyr Met 
            900                 905                 910         


Val Pro Ala Ala Val Val Ala Leu Asp Ala Ile Pro Leu Thr Pro Asn 
        915                 920                 925             


Gly Lys Leu Asp Thr Arg Ala Leu Pro Thr Pro Glu Tyr Ser Thr Gly 
    930                 935                 940                 


Glu Tyr Arg Ala Pro Glu Ser Pro Thr Glu Glu Ile Leu Ala Gly Ile 
945                 950                 955                 960 


Tyr Ala Glu Val Leu Gly Val Glu Arg Val Gly Val Asp Glu Ser Phe 
                965                 970                 975     


Phe Asp Leu Gly Gly Asp Ser Ile Ser Ala Met Arg Val Val Ala Arg 
            980                 985                 990         


Ala Arg Ala Ala Gly Leu Thr Cys  Arg Pro Arg Asp Val  Phe Val Glu 
        995                 1000                 1005             


Gln Thr  Val Ala Arg Leu Ala  Arg Val Val Gly Ser  Gly Asp Arg 
    1010                 1015                 1020             


Ala Ala  Glu Val Ala Asp Glu  Gly Val Gly Pro Val  Pro Pro Thr 
    1025                 1030                 1035             


Pro Ile  Met Arg Trp Leu Gln  Ala Ala Glu Arg Ala  Gly Gly Ala 
    1040                 1045                 1050             


Thr Asp  Gln Phe Asn Gln Thr  Val Leu Val Gln Ala  Pro Ala Gly 
    1055                 1060                 1065             


Val Thr  Glu Thr Glu Val Ala  Ile Val Leu Gln Ala  Leu Val Asp 
    1070                 1075                 1080             


Arg His  Ala Met Leu Arg Leu  Arg Val Thr Asp Asp  Gly Ala Asp 
    1085                 1090                 1095             


Gly Trp  Ser Phe Glu Val Pro  Glu Ala Gly Ser Val  Gln Ala Arg 
    1100                 1105                 1110             


Asp Cys  Leu Arg Ser Val Asp  Ala Leu Ser Asp Glu  Ala Leu Leu 
    1115                 1120                 1125             


Ala Ala  Arg Ala Arg Leu Asn  Pro Ala Ala Gly Thr  Met Leu Ala 
    1130                 1135                 1140             


Ala Leu  Trp Val Glu Ala Thr  Gly Gln Leu Ala Val  Ile Ile His 
    1145                 1150                 1155             


His Leu  Ala Val Asp Ala Val  Ser Trp Trp Ile Leu  Leu Glu Asp 
    1160                 1165                 1170             


Leu Asn  Ile Ala Trp Ala Leu  His Arg Ala Gly Gln  Pro Val Glu 
    1175                 1180                 1185             


Leu Ala  Pro Ala Gly Thr Ser  Phe Ala Arg Trp Ala  Arg Leu Leu 
    1190                 1195                 1200             


Asp Glu  His Ala Arg Asp Pro  Glu Val Val Gly Gln  Leu Asp Arg 
    1205                 1210                 1215             


Trp Lys  Thr Val Thr Ser Thr  Pro Ala Ala Leu Pro  Ala Pro Arg 
    1220                 1225                 1230             


Pro Asp  Val Asp Thr Tyr Ala  Ser Ala Gly Arg Leu  Ser Val Glu 
    1235                 1240                 1245             


Leu Asp  Ala Glu Thr Thr Ala  Met Leu Leu Gly Glu  Val Pro Ala 
    1250                 1255                 1260             


Ala Phe  His Ala Gly Ile His  Asp Ile Leu Leu Ile  Ala Phe Gly 
    1265                 1270                 1275             


Leu Ala  Trp Thr Glu Phe Leu  Gly Glu Pro Gly Ala  Pro Ile Gly 
    1280                 1285                 1290             


Ile Asp  Val Glu Gly His Gly  Arg His Glu Glu Leu  Gly Ala Asp 
    1295                 1300                 1305             


Ile Asp  Leu Ser Arg Thr Val  Gly Trp Phe Thr Ala  Lys Tyr Pro 
    1310                 1315                 1320             


Val Ser  Leu Asp Val Ala Gly  Leu Arg Trp Pro Gln  Val Ala Ala 
    1325                 1330                 1335             


Gly Asp  Pro Ala Leu Gly Pro  Val Leu Lys Arg Ala  Lys Glu Gln 
    1340                 1345                 1350             


Leu Arg  Thr Leu Pro Glu Pro  Leu Thr Tyr Gly Leu  Leu Arg Tyr 
    1355                 1360                 1365             


Leu Asn  Thr Asp Val Asp Leu  Ala Gly Ala Asp Pro  Pro Ile Ala 
    1370                 1375                 1380             


Phe Asn  Tyr Leu Gly Arg Gln  Gly Ala Ala Ser Asp  Ser Ala Ala 
    1385                 1390                 1395             


Asp Gly  Trp Arg Ile Ser Gln  Asp Met Ser Leu Leu  Gly Ala Ala 
    1400                 1405                 1410             


Ala Ala  Val Pro Met Pro Leu  Met His Ala Val Glu  Leu Asn Ala 
    1415                 1420                 1425             


Gly Thr  Ile Asp Thr Gly Ala  Gly Pro His Leu His  Ala Glu Trp 
    1430                 1435                 1440             


Thr Trp  Ala Pro Ser Val Leu  Gly Ala Glu Gln Ile  Thr Arg Val 
    1445                 1450                 1455             


Ser Arg  Leu Trp Phe Glu Ala  Leu Ala Gly Val Cys  Ala His Val 
    1460                 1465                 1470             


Arg Ser  Gly Gly Gly Gly Leu  Thr Pro Ser Asp Ile  Ala Pro Ala 
    1475                 1480                 1485             


Arg Leu  Thr Gln Gln Gln Ile  Asp Glu Leu Gln Ser  Arg His Arg 
    1490                 1495                 1500             


Ile Ala  Asp Ile Leu Pro Leu  Thr Pro Leu Gln Gln  Gly Leu Leu 
    1505                 1510                 1515             


Phe His  Ser Ser Thr Ala Gln  Gly Asn Asp Gly Met  Asp Asp Met 
    1520                 1525                 1530             


Tyr Ala  Val Gln Leu Asp Phe  Thr Leu Thr Gly Pro  Leu Asp Ala 
    1535                 1540                 1545             


Asp Arg  Leu Arg Glu Ala Val  Arg Thr Val Val His  Arg His Pro 
    1550                 1555                 1560             


His Leu  Ala Ala Leu Phe Cys  Asp Gln Tyr Asp Glu  Pro Val Gln 
    1565                 1570                 1575             


Ile Ile  Pro Ala Asp Pro Ala  Val Glu Trp Arg Tyr  Val Glu Leu 
    1580                 1585                 1590             


Asp Gly  Thr Gly Ala Ala Asp  Ala Asp Asp Leu Ile  Glu Gln Leu 
    1595                 1600                 1605             


Cys Ala  Ala Glu Arg Ala Ala  Val Ala Asp Leu Ala  Gly Gln Pro 
    1610                 1615                 1620             


Val Phe  Arg Thr Ala Leu Val  Arg Thr Gly Gly Asp  Arg His Arg 
    1625                 1630                 1635             


Phe Val  Leu Thr Ser His His  Ile Leu Leu Asp Gly  Trp Ser Leu 
    1640                 1645                 1650             


Pro Ile  Leu Leu Arg Glu Ile  Phe Ala Gly Tyr Tyr  Gly Gln Arg 
    1655                 1660                 1665             


Leu Pro  Ala Ala Gly Ser Tyr  Arg Ala Phe Leu Thr  Trp Leu Ala 
    1670                 1675                 1680             


Glu Arg  Asp Leu Asp Ala Ala  Arg Arg Ala Trp Gly  Glu Val Leu 
    1685                 1690                 1695             


Ser Gly  Phe Asp Thr Pro Thr  Leu Val Ala Pro Glu  Gly Arg Leu 
    1700                 1705                 1710             


Gly Gln  Gly Arg Arg Gly Phe  Glu Lys Ser Cys Val  Pro Glu Gln 
    1715                 1720                 1725             


Thr Thr  Arg Ala Leu Gly Glu  Leu Ala Arg Ser Cys  His Thr Thr 
    1730                 1735                 1740             


Leu Ser  Thr Val Leu Gln Ala  Ala Trp Ala Val Val  Leu Thr Ser 
    1745                 1750                 1755             


Leu Thr  Gly Arg His Asp Val  Val Phe Gly Thr Pro  Arg Ser Arg 
    1760                 1765                 1770             


Val Gly  Gln Leu Glu Val Asp  Asp Ala Glu Gln Met  Val Gly Leu 
    1775                 1780                 1785             


Leu Ile  Asn Ala Val Pro Val  Arg Ala Glu Ile Thr  Ala Thr Thr 
    1790                 1795                 1800             


Thr Thr  Ala Gln Leu Leu Ala  Gln Leu Gln Asn Ser  His Asn Asp 
    1805                 1810                 1815             


Thr Leu  Glu His Gln His Leu  Ala Leu Asn Glu Ile  His Arg Val 
    1820                 1825                 1830             


Thr Gly  His Asp Gln Leu Phe  Asp Thr Leu Phe Val  Tyr Glu Asn 
    1835                 1840                 1845             


Tyr Pro  Ile Asp Ser Gly Met  Thr Leu Gly Ala Asp  Gly Leu Ala 
    1850                 1855                 1860             


Ile Ala  Glu Phe Thr Asn Arg  Glu Tyr Asn His Tyr  Pro Leu Thr 
    1865                 1870                 1875             


Val Glu  Ala Leu Pro Gly Pro  Glu Leu Gly Leu His  Ile Glu Phe 
    1880                 1885                 1890             


Asp Thr  Asp Val Phe Asp Thr  Ala Ser Ile Glu Ser  Leu Val Gln 
    1895                 1900                 1905             


Arg Leu  Gln Arg Val Leu Val  Ala Met Ser Thr Asp  Pro Asp Arg 
    1910                 1915                 1920             


Arg Leu  Ser Ser Leu Asp Leu  Leu Asp Arg Gly Glu  Arg Glu Leu 
    1925                 1930                 1935             


Val Leu  Ser Thr Met Ser Gly  Ala Gly Val Ser Ala  Pro Ile Gly 
    1940                 1945                 1950             


Val Ala  Pro Gln Leu Leu Ala  Ala Ala Val Ala Ala  Asp Pro Asp 
    1955                 1960                 1965             


Ala Pro  Ala Ile Val Asp Gly  Ala Arg Glu Leu Ser  Tyr Arg Glu 
    1970                 1975                 1980             


Leu Asp  Asp Trp Ser Thr Arg  Leu Ala Arg Lys Leu  Ile Gln His 
    1985                 1990                 1995             


Gly Val  Gly Pro Glu His Ala  Ala Gly Val Ala Ile  Glu Arg Cys 
    2000                 2005                 2010             


Ala Glu  Leu Val Val Ala Trp  Trp Ala Val Thr Lys  Ala Gly Gly 
    2015                 2020                 2025             


Val Tyr  Ala Pro Val Asn Leu  Asp Tyr Pro Val Glu  Arg Ile Ala 
    2030                 2035                 2040             


Ser Val  Leu Asp Thr Val Asn  Ala Val Cys Val Leu  Thr Cys Gly 
    2045                 2050                 2055             


Thr Asp  Glu Val Ala Gly Ala  Gly Pro Arg Pro Ile  Leu Arg Ile 
    2060                 2065                 2070             


Asp Gly  Leu Asp Leu Ser Gly  His Ser Thr Glu Pro  Ile Thr Asp 
    2075                 2080                 2085             


Ala Asp  Arg Arg Ser Pro Leu  Arg Ala Asp Asp Thr  Ala Tyr Leu 
    2090                 2095                 2100             


Ile Phe  Thr Ser Gly Ser Thr  Gly Val Pro Lys Gly  Val Ala Val 
    2105                 2110                 2115             


Ser His  Thr Gly Leu Leu Gly  Trp Ala Ala Ala Gln  Arg Glu Leu 
    2120                 2125                 2130             


Phe Gly  Leu Gly Ala Asp Ala  Arg Val Leu Met Val  Ala Ser Pro 
    2135                 2140                 2145             


Thr Phe  Asp Ala Ser Val Gly  Glu Leu Leu Leu Ala  Ala Gly Ser 
    2150                 2155                 2160             


Gly Ala  Ala Leu Ile Val Ala  Pro Pro Gln Val Tyr  Ala Gly Glu 
    2165                 2170                 2175             


Ala Leu  Thr Ala Leu Leu His  Asn Gln Arg Val Gly  Thr Ala Ile 
    2180                 2185                 2190             


Leu Thr  Pro Thr Val Ile Ser  Thr Leu Asp Arg Gly  Arg Leu Asp 
    2195                 2200                 2205             


Gly Leu  His Thr Leu Val Ala  Val Gly Glu Ala Cys  Leu Pro Glu 
    2210                 2215                 2220             


Leu Val  Asp Gly Trp Ala Pro  Gly Arg Gln Met Phe  Asn Gly Tyr 
    2225                 2230                 2235             


Gly Pro  Ser Glu Thr Thr Ile  Trp Val Thr Cys Ala  Arg Leu Thr 
    2240                 2245                 2250             


Ala Gly  His Pro Val Arg Ile  Gly Ala Pro Ile Pro  Gly Val Cys 
    2255                 2260                 2265             


Ala Arg  Val Leu Asp Gly Trp  Leu Lys Pro Val Pro  Val Gly Val 
    2270                 2275                 2280             


Val Gly  Glu Leu Tyr Leu Ser  Gly Pro Ala Leu Gly  His Gly Tyr 
    2285                 2290                 2295             


Leu Gly  Arg Val Asp Leu Thr  Ala Glu Arg Phe Val  Ala Asn Pro 
    2300                 2305                 2310             


Phe Gly  Gly Pro Gly Glu Arg  Met Tyr Arg Thr Gly  Asp Leu Val 
    2315                 2320                 2325             


Arg Trp  Thr Pro Glu Gly Thr  Leu Asp Tyr Leu Gly  Arg Ala Asp 
    2330                 2335                 2340             


Asn Gln  Ile Lys Leu Arg Gly  Gln Arg Ile Glu Leu  Gly Glu Ile 
    2345                 2350                 2355             


Glu Asn  Thr Leu Leu Ala Cys  Pro Gln Val Thr Gln  Ala Ala Val 
    2360                 2365                 2370             


Thr Val  Gln Asp Ser Ala Ala  Gly Ser Gln Leu Val  Ala Tyr Val 
    2375                 2380                 2385             


Thr Leu  Asp His Gly Pro Ser  Asp Ala Asp Val Arg  His Asp Thr 
    2390                 2395                 2400             


Asp Asp  Ala Asp Asp Val Ala  Gln Trp Arg His Leu  Tyr Asp Asp 
    2405                 2410                 2415             


Leu Tyr  Gly Ala Asp Leu Ala  Ala Thr Phe Gly Glu  Asp Phe Arg 
    2420                 2425                 2430             


Gly Trp  Asn Ser Ser Tyr Thr  Gly Glu Pro Ile Pro  Leu Gln Glu 
    2435                 2440                 2445             


Met Ala  Glu Trp Arg Ser Ala  Thr Val Asp Arg Ile  Met Ser Leu 
    2450                 2455                 2460             


Arg Pro  Arg Arg Val Leu Glu  Ile Gly Ala Gly Ser  Gly Leu Leu 
    2465                 2470                 2475             


Leu Ser  Gln Ile Ala Pro Arg  Cys Asp Arg Tyr Val  Ala Thr Asp 
    2480                 2485                 2490             


Phe Ser  Ala Val Ala Ile Asp  Asn Leu Ala Arg Ser  Met Glu Gln 
    2495                 2500                 2505             


Leu Gln  Leu Pro Trp Arg Asp  Arg Val Glu Leu Leu  Thr Gln Pro 
    2510                 2515                 2520             


Ala His  Val Thr Asp Gly Leu  Pro Pro Gly His Phe  Asp Thr Ile 
    2525                 2530                 2535             


Val Ile  Asn Ser Val Val Gln  Tyr Phe Pro Asn Ala  Gly Tyr Leu 
    2540                 2545                 2550             


Ala Asp  Val Ile Asp Asn Ala  Leu Glu Leu Leu Ala  Pro Gly Gly 
    2555                 2560                 2565             


Ser Leu  Phe Ile Gly Asp Val  Arg Asn His Ala Leu  Gln Gly Ala 
    2570                 2575                 2580             


Phe Gln  Thr Gly Ile Ala Leu  Ala Arg Gly Gly Gly  Ala Asp Ala 
    2585                 2590                 2595             


Ala Glu  Ile Arg Gln Arg Val  Arg His Ala Met Leu  Gly Glu Thr 
    2600                 2605                 2610             


Glu Leu  Leu Leu Ala Pro Glu  Phe Phe Thr Asn Trp  Ala Asp Ser 
    2615                 2620                 2625             


Arg Pro  Ala Ala Ala Gly Leu  Asp Ile Gln Leu Lys  Arg Gly Leu 
    2630                 2635                 2640             


Ser Asp  Asn Glu Leu Asn Arg  Tyr Arg Tyr Asp Val  Val Ile His 
    2645                 2650                 2655             


Lys Ala  Pro Ala Pro Val Arg  Ser Val Ala Ala Ala  Pro Thr Trp 
    2660                 2665                 2670             


Ser Trp  Thr Asp Cys Thr Asp  Cys Ala Gly Leu Arg  Asp Gln Leu 
    2675                 2680                 2685             


Ala Ala  Arg Arg Pro Ala Val  Val Arg Val Thr Asp  Ile Pro Gln 
    2690                 2695                 2700             


Ala Gly  Val Ile Asp Asp Val  Arg Val Glu Ala Ala  Leu Ala Ala 
    2705                 2710                 2715             


Gly Leu  Pro Val Ala Asp Ala  Leu Ala Ala Ala Gly  Ser Asp Thr 
    2720                 2725                 2730             


Ala Ala  Ala Val Ala Glu Glu  Leu His Arg Val Gly  Glu Ala Thr 
    2735                 2740                 2745             


Gly Tyr  Arg Val Ala Val Thr  Trp Gly Ala Gln Pro  Gly Thr Leu 
    2750                 2755                 2760             


Ser Ala  Val Phe Val Gln Asp  Gly Asp Gln Ala Ala  Glu Pro Leu 
    2765                 2770                 2775             


Thr Asp  Leu Tyr Leu Pro Pro  Ala Gly Ala Arg Gln  Arg Thr Arg 
    2780                 2785                 2790             


His Ala  Asn Asp Pro Arg Ala  Asn Thr Lys Ile Ala  Gln Val Arg 
    2795                 2800                 2805             


Glu Arg  Leu Asn Ala Trp Leu  Pro Glu Tyr Met Val  Pro Thr His 
    2810                 2815                 2820             


Ile Val  Ala Leu Asp Glu Phe  Pro Met Thr Thr Ser  Gly Lys Leu 
    2825                 2830                 2835             


Asp Arg  Lys Ala Leu Pro Ala  Pro Asp Tyr Gln Asp  Ala Asp Arg 
    2840                 2845                 2850             


Tyr Arg  Ala Pro Ser Thr Ala  Val Glu Glu Ile Leu  Val Gly Ile 
    2855                 2860                 2865             


Tyr Gly  Gln Val Leu Gly Leu  Glu Arg Val Gly Val  Asp Asp Ser 
    2870                 2875                 2880             


Phe Phe  Asp Leu Gly Gly Asp  Ser Leu Ser Ala Met  Arg Leu Ile 
    2885                 2890                 2895             


Ala Ala  Val Asn Ala Ser Leu  Asn Thr Asp Leu Gly  Val Arg Thr 
    2900                 2905                 2910             


Val Phe  Glu Ala Pro Thr Ala  Ala Glu Leu Ala Leu  Arg Val Gly 
    2915                 2920                 2925             


Ser Glu  Ala Asp Arg Pro Glu  Pro Leu Val Ala Gly  Glu Arg Pro 
    2930                 2935                 2940             


Ala Val  Ile Pro Leu Ser Phe  Ala Gln Thr Arg Leu  Trp Phe Ile 
    2945                 2950                 2955             


Asp Gln  Phe Gln Gly Pro Ser  Pro Met Tyr Asn Ile  Thr Val Ala 
    2960                 2965                 2970             


Leu Arg  Leu Ser Gly Arg Leu  Asp Ala Asp Ala Leu  Arg Ala Ala 
    2975                 2980                 2985             


Leu Ala  Asp Val Val Ala Arg  His Glu Ser Leu Arg  Thr Val Phe 
    2990                 2995                 3000             


Ala Thr  Ala Asp Ala Thr Pro  Gln Gln Val Val Ile  Pro Ala Asp 
    3005                 3010                 3015             


Arg Ile  Gly Phe Ala Cys Asp  Val Val Asp Ala Arg  Gly Trp Pro 
    3020                 3025                 3030             


Glu Asp  Arg Leu Arg Glu Ala  Met Ser Ala Ala Ala  Arg Tyr Thr 
    3035                 3040                 3045             


Phe Asp  Leu Ser Ala Glu Ser  Pro Leu His Thr Glu  Leu Phe Ala 
    3050                 3055                 3060             


Arg Gly  Asp Asp Glu His Val  Leu Val Val Ala Val  His His Ile 
    3065                 3070                 3075             


Ala Ala  Asp Gly Trp Ser Ile  Thr Pro Phe Ala Arg  Asp Leu Gly 
    3080                 3085                 3090             


Val Ala  Tyr Ala Ser Arg Cys  Ala Gly Arg Asp Pro  Asp Trp Ala 
    3095                 3100                 3105             


Pro Leu  Pro Val Gln Tyr Ala  Asp Tyr Thr Leu Trp  Gln Arg Ala 
    3110                 3115                 3120             


His Leu  Gly Asp Val Asp Asp  Pro Gly Ser Arg Ile  Ala Ala Gln 
    3125                 3130                 3135             


Leu Asp  Phe Trp Thr Asp Ala  Leu Ala Gly Leu Pro  Glu Arg Leu 
    3140                 3145                 3150             


Gln Leu  Pro Thr Asp Arg Pro  Tyr Pro Ala Val Ala  Asp His Arg 
    3155                 3160                 3165             


Gly Ala  Arg Leu Ala Val Asp  Trp Pro Ala Glu Leu  Gln Gln Arg 
    3170                 3175                 3180             


Ile Gly  Asp Val Ala His Arg  His Asp Ala Thr Ser  Phe Met Val 
    3185                 3190                 3195             


Ile Gln  Thr Ala Leu Thr Val  Leu Leu Ala Lys Leu  Gly Ala Asn 
    3200                 3205                 3210             


Pro Asp  Val Ala Val Gly Phe  Pro Ile Ala Gly Arg  Arg Asp Pro 
    3215                 3220                 3225             


Ala Leu  Asp Asp Leu Val Gly  Phe Phe Val Asn Thr  Leu Val Leu 
    3230                 3235                 3240             


Arg Val  Asp Ala Ala Gly Asp  Pro Ser Phe Thr Glu  Leu Leu Ala 
    3245                 3250                 3255             


Arg Val  Arg Thr Arg Ser Leu  Glu Ala Phe Glu His  Gln Asp Val 
    3260                 3265                 3270             


Pro Phe  Glu Val Leu Val Glu  Arg Leu Asn Pro Thr  Arg Ser Leu 
    3275                 3280                 3285             


Thr His  His Pro Leu Val Gln  Val Met Leu Ala Trp  Gln Asn Phe 
    3290                 3295                 3300             


Ala Gly  Gln Asp Thr Gly Pro  Ala Ala Gly Leu Ser  Leu Gly Asp 
    3305                 3310                 3315             


Val Glu  Ile Thr Pro Ile Pro  Val Asp Thr His Thr  Ala Arg Met 
    3320                 3325                 3330             


Asp Leu  Thr Phe Ser Val Gly  Glu Arg Trp Cys Glu  Ser Gly Glu 
    3335                 3340                 3345             


Pro Gly  Gly Ile Gly Gly Thr  Val Glu Phe Arg Thr  Asp Val Phe 
    3350                 3355                 3360             


Asp Pro  Asp Ser Ile Gln Thr  Leu Ile Gly Arg Leu  Arg Arg Val 
    3365                 3370                 3375             


Leu Glu  Ala Met Thr Asp Asp  Pro Thr Gln Ser Val  Trp Ser Val 
    3380                 3385                 3390             


Asp Leu  Leu Asp Ala Gly Glu  His Ala Arg Leu Asp  Thr Leu Gly 
    3395                 3400                 3405             


Asn Arg  Ala Ala Leu Thr Gly  Pro Pro Pro Arg Phe  Asp Ser Leu 
    3410                 3415                 3420             


Pro Thr  Leu Phe Ala Glu Gln  Ala Ala Arg Thr Pro  Asp Ala Val 
    3425                 3430                 3435             


Ala Leu  Val Cys Gly Gly Arg  Arg Met Thr Tyr Arg  Glu Leu Asp 
    3440                 3445                 3450             


Glu Ala  Ser Asn Arg Leu Ala  His Leu Leu Ala Gly  Leu Gly Ala 
    3455                 3460                 3465             


Gly Pro  Gly Gln Ser Val Ala  Leu Leu Phe Ser Arg  Ser Ala Glu 
    3470                 3475                 3480             


Ala Ile  Val Ala Ile Leu Gly  Val Leu Lys Ser Gly  Ala Ala Tyr 
    3485                 3490                 3495             


Leu Pro  Ile Asp Pro Ala Leu  Pro Gly Glu Arg Ile  Gly Phe Met 
    3500                 3505                 3510             


Leu Ala  Asp Ala Ala Pro Met  Val Ala Ile Ser Thr  Ala Glu Leu 
    3515                 3520                 3525             


Ala Pro  Arg Leu His Gly Gln  His Asp Val Pro Val  Ile Asp Val 
    3530                 3535                 3540             


His Asp  Pro Ala Ile Glu Ala  Ala Pro Ser Ser Ala  Leu Pro Pro 
    3545                 3550                 3555             


Pro Gly  Ala Asp Asp Ile Ala  Tyr Leu Ile Tyr Thr  Ser Gly Thr 
    3560                 3565                 3570             


Thr Gly  Val Pro Lys Gly Val  Ala Val Ser His Arg  Asn Val Thr 
    3575                 3580                 3585             


Gln Leu  Leu Thr Ala Asp Ser  Gly Leu Pro Arg Glu  Gly Val Trp 
    3590                 3595                 3600             


Ser Gln  Trp His Ser Leu Ala  Phe Asp Val Ser Val  Trp Glu Ile 
    3605                 3610                 3615             


Phe Gly  Ala Leu Leu His Gly  Gly Arg Leu Val Val  Ile Pro Asp 
    3620                 3625                 3630             


Ser Val  Val Arg Ser Pro Asp  Asp Phe His Ala Leu  Leu Leu Asp 
    3635                 3640                 3645             


Glu Gln  Val Ser Val Leu Ser  Gln Thr Pro Ser Ala  Ala Gly Thr 
    3650                 3655                 3660             


Leu Ser  Pro Glu Gly Leu Glu  Asp Leu Thr Leu Val  Val Ala Gly 
    3665                 3670                 3675             


Glu Ala  Cys Pro Ala Glu Leu  Val Asp Arg Trp Ala  Pro Gly Arg 
    3680                 3685                 3690             


Thr Met  Ile Asn Ala Tyr Gly  Pro Thr Glu Ala Thr  Val Tyr Thr 
    3695                 3700                 3705             


Ala Ile  Ser Ala Pro Leu Gln  Pro Gly Ser Pro Ala  Gly Val Pro 
    3710                 3715                 3720             


Ile Gly  Phe Pro Val Pro Gly  Ala Gly Leu Phe Val  Leu Asp Glu 
    3725                 3730                 3735             


Ser Leu  Arg Pro Val Pro Pro  Gly Val Val Gly Glu  Leu Tyr Val 
    3740                 3745                 3750             


Ala Gly  Ala Gly Val Ala Cys  Gly Tyr Trp Arg Arg  Gly Gly Leu 
    3755                 3760                 3765             


Thr Ala  Ser Arg Phe Val Ala  Cys Pro Phe Gly Ala  Pro Gly Ala 
    3770                 3775                 3780             


Arg Met  Tyr Arg Thr Gly Asp  Leu Val Cys Trp Arg  Ser Asp Gly 
    3785                 3790                 3795             


Gln Leu  Asp Tyr Arg Gly Arg  Ala Asp Glu Gln Val  Lys Val Arg 
    3800                 3805                 3810             


Gly Tyr  Arg Ile Glu Leu Gly  Glu Val Gln Ala Ala  Leu Ala Ala 
    3815                 3820                 3825             


Leu Asp  Asp Val Asp Gln Ala  Val Val Ile Ala Arg  Glu Asp Arg 
    3830                 3835                 3840             


Pro Gly  Gly Lys Arg Leu Val  Gly Tyr Ile Thr Gly  Thr Ala Asp 
    3845                 3850                 3855             


Pro Ala  Glu Val Arg Thr Ala  Leu Ala Gln Arg Leu  Pro Val Tyr 
    3860                 3865                 3870             


Met Val  Pro Ala Ala Val Val  Ala Leu Asp Ala Ile  Pro Leu Thr 
    3875                 3880                 3885             


Pro Asn  Gly Lys Leu Asp Thr  Arg Ala Leu Pro Thr  Pro Glu Tyr 
    3890                 3895                 3900             


Thr Gly  Ser Arg Tyr Arg Ala  Pro Ser Asn Ala Val  Glu Glu Thr 
    3905                 3910                 3915             


Val Ala  Gly Ile Tyr Ala His  Val Leu Gly Val Glu  Arg Val Gly 
    3920                 3925                 3930             


Val Asp  Asp Ser Phe Phe Asp  Leu Gly Gly Asp Ser  Ile Ser Ala 
    3935                 3940                 3945             


Met Arg  Val Ile Thr Ala Ile  Asn Ala Ser Leu Gly  Val Glu Leu 
    3950                 3955                 3960             


Ala Val  Arg Thr Leu Phe Glu  Ala Pro Thr Val Ala  Ser Leu Ser 
    3965                 3970                 3975             


Trp Arg  Ala Gln Thr Asp Thr  Ala Arg Gly Gly Gln  Ala Glu Glu 
    3980                 3985                 3990             


Ile Val  Pro Val Gln Thr Leu  Lys Glu Gly Thr Gly  Ala Pro Leu 
    3995                 4000                 4005             


Phe Cys  Ile His Ala Ala Gly  Gly Leu Ser Trp Ser  Tyr Gln Val 
    4010                 4015                 4020             


Leu Gly  Asn His Leu Asp Cys  Pro Ile Ile Gly Ile  Gln Gln Ala 
    4025                 4030                 4035             


Glu Pro  Gln His Ala Ala Pro  Arg Ser Ile Arg Glu  Met Ala Gln 
    4040                 4045                 4050             


Ser Tyr  Ala Asp Arg Ile Gln  Glu Thr Tyr Pro Asp  Gly Pro Tyr 
    4055                 4060                 4065             


His Leu  Val Gly Trp Ser Phe  Gly Gly Val Val Ala  His Glu Leu 
    4070                 4075                 4080             


Ala Ile  Glu Leu Gln Arg Arg  Gly Cys Ala Ile Ala  Arg Leu Val 
    4085                 4090                 4095             


Leu Leu  Asp Ala Gln Pro Gly  Leu Asp Gly Ser Val  Thr Ala Pro 
    4100                 4105                 4110             


Asp Ala  Ala Leu Ala Glu Gln  His Met Met Glu Glu  Ala Leu Arg 
    4115                 4120                 4125             


Ser His  Leu Ala Ala Ala Asp  His Asp Gln Pro His  Ala His Arg 
    4130                 4135                 4140             


Gln Phe  Asn Gln Leu Val Arg  Glu Ala Gly Ala Glu  Gly Met Ser 
    4145                 4150                 4155             


Arg His  Lys Arg Leu Phe Asp  Val Leu Phe Gly Asn  Ala Arg Asn 
    4160                 4165                 4170             


Asn Ile  Glu Arg Ser Lys Ile  His Glu Pro Gly Val  Phe Leu Gly 
    4175                 4180                 4185             


Asp Val  Thr Ile Phe Ser Ala  Val Arg Asp His Glu  Asp Arg Ser 
    4190                 4195                 4200             


Ala Phe  Leu Ala Glu Asn Trp  Arg Pro Tyr Val Ala  Gly Asp Ile 
    4205                 4210                 4215             


Val Ile  His Glu Ile Asp Cys  Thr His Asp Glu Ile  Leu Asn Ala 
    4220                 4225                 4230             


Asp Val  Val Asp Ser Tyr Gly  Gln Arg Leu Gly Gln  Leu Leu Gly 
    4235                 4240                 4245             


Ala Gln  Arg Arg Arg Glu Leu  Thr Pro Pro Gln Arg  Phe Gly Ala 
    4250                 4255                 4260             


Asp Pro  Gly Asp Asp Glu Pro  Pro Val Arg 
    4265                 4270             


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  18
cttgagcagc tcgtaaagcg t                                                 21


<210>  19
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
gctgtatgag gaagtctatt catgg                                             25


<210>  20
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
aacgagagga agaactaagc cg                                                22


<210>  21
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
ttacggagca ggaaggccag cggg                                              24


<210>  22
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
gtcaagggat cggcgagg                                                     18


<210>  23
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
tggacttgag cacggtcat                                                    19


<210>  24
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
cgttgcgatt tctgcgtagc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  25
ggtgatggtc gtggtcatcc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  26
catatctggc atggctccag                                                   20


<210>  27
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  27
atcgtgttga ccccaaagaa at                                                22


<210>  28
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
acaacgaaac ctacctcgtc                                                   20


<210>  29
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  29
gtgagctggc ggcctaac                                                     18


<210>  30
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  30
gacgagcagc tgtccgag                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  31
gagagcgtgg ccatcgag                                                     18


<210>  32
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  32
ccacagggtt tttggtgaag                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  33
ggaaatccaa cagcaaggac                                                   20


<210>  34
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  34
cgcggcgagc gggagctggt gc                                                22


<210>  35
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  35
cgcagcgggg agcgccggtc gg                                                22


<210>  36
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  rpimer

<400>  36
ggcgttacag aattgccttg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  37
gctcgaagtt ggagatcagg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  38
gtacgtggtg accaatgtcg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  39
tagaaggtgc gggaaagttg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  40
gtctatctgg cggtgctctc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  41
gtcgaagcag cgttgattgt                                                   20


<210>  42
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  42
tgttcttcac cacccagggc cggg                                              24


<210>  43
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  43
ttgagcgaca gcaggtagtc gtcggcg                                           27


<210>  44
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  44
ttggtgcgcc gcaagagcgc aaccg                                             25


<210>  45
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  45
atttcagctt gtacagcggt ggc                                               23


