                         SEQUENCE LISTING

<110>  ԴҽҩƼϺ޹˾
 
<120>  PD-1弰;

<130>  201612

<160>  42    

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  CDR-H1

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  CDR-H1

<400>  2

Gly Ile Thr Phe Ser Asn Ser Gly 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  CDR-H2

<400>  3

Ile Ser Gly Gly Gly Arg Asp Thr 
1               5               


<210>  4
<211>  7
<212>  PRT
<213>  CDR-H2

<400>  4

Trp Tyr Asp Gly Ser Lys Arg 
1               5           


<210>  5
<211>  11
<212>  PRT
<213>  CDR-H3

<400>  5

Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His 
1               5                   10      


<210>  6
<211>  6
<212>  PRT
<213>  CDR-H3

<400>  6

Ala Thr Asn Asp Asp Tyr 
1               5       


<210>  7
<211>  10
<212>  PRT
<213>  CDR-L1

<400>  7

Glu Ser Val Asp Asp Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  8
<211>  6
<212>  PRT
<213>  CDR-L1

<400>  8

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  mAb1 CDR-L2

<400>  9

Val Ala Ser 
1           


<210>  10
<211>  3
<212>  PRT
<213>  CDR-L2

<400>  10

Asp Ala Ser 
1           


<210>  11
<211>  9
<212>  PRT
<213>  CDR-L3

<400>  11

Gln Gln Ser Lys Glu Val Pro Trp Thr 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  CDR-L3

<400>  12

Gln Gln Ser Ser Asn Trp Pro Arg Thr 
1               5                   


<210>  13
<211>  118
<212>  PRT
<213>  ԴAB12M1ǶϿAB12M2ɱ

<400>  13

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  14
<211>  111
<212>  PRT
<213>  ԴAB12M1ǶϿAB12M2ɱ

<400>  14

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  15
<211>  111
<212>  PRT
<213>  ԴAB12N1ǶϿAB12N2ɱ

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110     


<210>  16
<211>  107
<212>  PRT
<213>  ԴAB12N1ǶϿAB12N2ɱ

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  17
<211>  118
<212>  PRT
<213>  ԴAB12M3ɱ

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  18
<211>  111
<212>  PRT
<213>  ԴAB12M3ɱ

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  19
<211>  118
<212>  PRT
<213>  ԴAB12M4ɱ

<400>  19

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  20
<211>  111
<212>  PRT
<213>  ԴAB12M4ɱ

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Val Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  21
<211>  118
<212>  PRT
<213>  ԴAB12M5ɱ

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  22
<211>  107
<212>  PRT
<213>  ԴAB12M5ɱ

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Val Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  23
<211>  118
<212>  PRT
<213>  ԴAB12M6ɱ

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  24
<211>  107
<212>  PRT
<213>  ԴAB12M6ɱ

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Val Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  118
<212>  PRT
<213>  ԴAB12M7ɱ

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  26
<211>  107
<212>  PRT
<213>  ԴAB12M7ɱ

<400>  26

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Val Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  118
<212>  PRT
<213>  ԴAB12M8ɱ

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  28
<211>  107
<212>  PRT
<213>  ԴAB12M8ɱ

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Val Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  29
<211>  118
<212>  PRT
<213>  ԴAB12M9ɱ

<400>  29

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Lys Asp Thr Ser Trp Phe Val His Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  30
<211>  107
<212>  PRT
<213>  ԴAB12M9ɱ

<400>  30

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Asp Tyr 
            20                  25                  30          


Gly Ile Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Val Ala Ser Asn Arg Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  31
<211>  110
<212>  PRT
<213>  ԴAB12N3ɱ

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110 


<210>  32
<211>  107
<212>  PRT
<213>  ԴAB12N3ɱ

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  111
<212>  PRT
<213>  ԴAB12N4ɱ

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110     


<210>  34
<211>  107
<212>  PRT
<213>  ԴAB12N4ɱ

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  110
<212>  PRT
<213>  ԴAB12N5ɱ

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110 


<210>  36
<211>  107
<212>  PRT
<213>  ԴAB12N5ɱ

<400>  36

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  354
<212>  DNA
<213>  ǶϿAB12M2ɱ

<400>  37
gaggtgaagc tggtggagag cggaggagga ctggtgaagc caggaggatc tctgaagctg     60

agctgtgctg cctctggctt caccttttcc tcttacggca tgagctgggt gagacagaca    120

cccgagaagc gcctggaatg ggtcgctacc atctctggcg gcggcagaga cacatactat    180

cctgattccg tgaagggcag attcaccatc agccgcgata acgccaaaaa taatctgtat    240

ctgcaaatgt cttccctgag gtctgaggac accgctctgt actattgcgc ccggcagaag    300

gatacatctt ggttcgtgca ctggggacag ggcaccctgg tgaccgtgtc cgcc          354


<210>  38
<211>  333
<212>  DNA
<213>  ǶϿAB12M2ɱ

<400>  38
gacatcgtgc tgacccagtc tccagctagc ctggccgtgt ccctgggaca gagggctacc     60

atcagctgtc gggcctctga gtctgtcgac gattacggca tctctttcat gaattggttc    120

cagcagaaac ctggccagcc ccctaaactg ctgatctatg tcgcttccaa tcagggaagc    180

ggagtgcctg ctagattcag cggatctgga tctggaaccg acttcagcct gaacatccat    240

ccaatggagg aggacgatac cgccatgtac ttctgtcagc agtctaaaga agtcccttgg    300

acctttggcg gcggcacaaa gctggagatc aag                                 333


<210>  39
<211>  354
<212>  DNA
<213>  ԴAB12M3ɱ

<400>  39
gaggtgcagc tggtggagtc cggaggagga ctggtgcagc ctggaggcag cctgagactg     60

tcttgcgccg cttccggctt caccttttcc agctacggca tgtcttgggt gagacaggct    120

cctggcaagg gactggagtg ggtggctacc atctccggag gaggaaggga cacatactat    180

ccagatagcg tgaagggcag gttcacaatc tctcgggaca acgctaagaa caatctgtat    240

ctgcagatga actccctgag agctgaggac accgccctgt actattgcgc ccgccagaag    300

gatacaagct ggtttgtgca ctggggccag ggcaccctgg tgacagtgtc ttcc          354


<210>  40
<211>  333
<212>  DNA
<213>  ԴAB12M3ɱ

<400>  40
gagatcgtgc tgacccagag ccctgccaca ctgagcctgt ctccaggcga gagggctacc     60

ctgtcttgtc gggcctccga gagcgtggac gattacggca tctccttcat gaactggttt    120

cagcagaagc caggccaggc tcccaagctg ctgatctatg tggccagcaa tcagggctct    180

ggagtgccag ctcgcttctc tggctccgga agcggaaccg acttttctct gacaatcagc    240

tctctggagc cagacgatac agccatgtac ttctgccagc agtccaagga ggtgccatgg    300

acctttggcg gaggaacaaa ggtggagatc aag                                 333


<210>  41
<211>  354
<212>  DNA
<213>  ԴAB12M4ɱ

<400>  41
gaggtgcagc tggtggagag cggaggagga ctggtgaagc caggaggatc tctgaggctg     60

agctgtgctg cctctggctt caccttttcc tcttacggca tgagctgggt gagacagaca    120

cccgagaagc gcctggaatg ggtcgctacc atctctggcg gcggcagaga cacatactat    180

cctgattccg tgaagggcag attcaccatc agccgcgata acgccaaaaa taatctgtat    240

ctgcaaatgt cttccctgag gtctgaggac accgctctgt actattgcgc ccggcagaag    300

gatacatctt ggttcgtgca ctggggacag ggcaccctgg tgaccgtgtc ctcc          354


<210>  42
<211>  333
<212>  DNA
<213>  ԴAB12M4ɱ

<400>  42
gaaatcgtgc tgacccagtc tccagctaca ctggccgtgt cccctggaga gagggctacc     60

atcagctgtc gggcctctga gtctgtcgac gattacggca tctctttcat gaattggttc    120

cagcagaaac ctggccagcc ccctaaactg ctgatctatg tcgcttccaa tcagggaagc    180

ggagtgcctg ctagattcag cggatctgga tctggaaccg acttcaccct gaacatccat    240

ccaatggagg aggacgatac cgccatgtac ttctgtcagc agtctaaaga agtcccttgg    300

acctttggcg gcggcacaaa gctggagatc aag                                 333


