                               SEQUENCE LISTING

<110> TWIST BIOSCIENCE CORPORATION
 
<120> VARIANT LIBRARIES OF THE IMMUNOLOGICAL SYNAPSE AND SYNTHESIS 
      THEREOF

<130> 44854-731.601

<140> PCT/US2017/066847
<141> 2017-12-15

<150> 62/435,650
<151> 2016-12-16

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 2
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
atgtttagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 3
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
atgttaagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 4
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
atgattagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 5
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
atgtctagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 6
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
atgcctagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 7
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
atgactagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 8
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
atggctagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 9
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
atgtatagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 10
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
atgcatagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 11
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
atgcaaagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 12
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
atgaatagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 13
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
atgaaaagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 14
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
atggatagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 15
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
atggaaagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 16
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
atgtgtagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 17
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
atgtggagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 18
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
atgcgtagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 19
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
atgggtagca agggcgagga gctgttcacc ggggtggtgc ccat                        44


<210> 20
<211> 62
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
agacaatcaa ccatttgggg tggacagcct tgacctctag acttcggcat tttttttttt       60

tt                                                                      62


<210> 21
<211> 112
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
cgggatcctt atcgtcatcg tcgtacagat cccgacccat ttgctgtcca ccagtcatgc       60

tagccatacc atgatgatga tgatgatgag aaccccgcat tttttttttt tt              112


<210> 22
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 22
atgcggggtt ctcatcatc                                                    19


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer 

<400> 23
cgggatcctt atcgtcatcg                                                   20


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Ala Trp Ile Lys Arg Glu Gln 
1               5           


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<400> 25
Xaa Trp Ile Lys Arg Glu Gln 
1               5           


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<400> 26
Ala Xaa Ile Lys Arg Glu Gln 
1               5           


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<400> 27
Ala Trp Xaa Lys Arg Glu Gln 
1               5           


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 28
Ala Trp Ile Xaa Arg Glu Gln 
1               5           


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 29
Ala Trp Ile Lys Xaa Glu Gln 
1               5           


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Any amino acid

<400> 30
Ala Trp Ile Lys Arg Xaa Gln 
1               5           


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<400> 31
Ala Trp Ile Lys Arg Glu Xaa 
1               5           


<210> 32
<211> 664
<212> DNA
<213> Homo sapiens

<400> 32
atgtggggag ctttccttct ctatgtttcc atgaagatgg gaggtgagtc tcaatctaat       60

agtaaatgct gctaggaatt ttcaaaacaa tttcctttca gctaaattat tgcaaatttt      120

gacatttgta atgagagtat ttcctgaata tgcattttcc taacgtggtg ctaattgtcc      180

tcctgttact attgctgctg ctgttactgc aaccatttat ttcagtctaa gaaattctcc      240

catcaatggc agttcttttg tgaccacatg gaagcatcat ttaaaaaatt attccaatag      300

tttttggagg aaacatcatt tttaataatg atggggcttc tgggggtgct gccctagtaa      360

caatcatgta tcttgtcata ggcactgcag gacaaagcct tgagcagccc tctgaagtga      420

cagctgtgga aggagccatt gtccagataa actgcacgta ccagacatct gggttttatg      480

ggctgtcctg gtaccagcaa catgatggcg gagcacccac atttctttct tacaatgctc      540

tggatggttt ggaggagaca ggtcgttttt cttcattcct tagtcgctct gatagttatg      600

gttacctcct tctacaggag ctccagatga aagactctgc ctcttacttc tgcgctgtga      660

gaga                                                                   664


<210> 33
<211> 764
<212> DNA
<213> Homo sapiens

<400> 33
atgaggcaag tggcgagagt gatcgtgttc ctgaccctga gtgagttatt ttgggatgaa       60

gaggaatggg atctgggcct gatgatgctg gaaaggaatc tggaactttg cctgctagca      120

gttgctcttt atccaagatg tagagggata gcttcagggt tccatttttc tccaggcagc      180

tcctgagcat ttatgtgaga tgtgtctcag ggcagcaaag attttcgggg tttctaatcc      240

ctagggtcta tccatgggag ggagatagta aacctgacac ttctgtgtat gcctgggata      300

aatatttttg tactgaaaca taaatgagaa gtaaattgta tgtacatgta tatggcaggg      360

aagtagagcg tggggatgga tttgactgtg agagggaacc gtggggctac tgagtgggac      420

cgtctaactt accttgcttt caggataggg gctaggattg tgttttactc ccataggtac      480

tttgagcctt gctaagacca cccagcccat ctccatggac tcatatgaag gacaagaagt      540

gaacataacc tgtagccaca acaacattgc tacaaatgat tatatcacgt ggtaccaaca      600

gtttcccagc caaggaccac gatttattat tcaaggatac aagacaaaag ttacaaacga      660

agtggcctcc ctgtttatcc ctgccgacag aaagtccagc actctgagcc tgccccgggt      720

ttccctgagc gacactgctg tgtactactg cctcgtgggt gaca                       764


<210> 34
<211> 468
<212> DNA
<213> Homo sapiens

<400> 34
atgctcctgt tgctcatacc agtgctgggg atgatttttg ccctgagtga gtaacattct       60

attatggtct ctagttccac agaagtaact gttttctgat tcaaatctta gtagaaatac      120

ttttcataga caagtctgca ctattttcac tgatacaaca ttgatttttt caggagatgc      180

cagagcccag tctgtgagcc agcataacca ccacgtaatt ctctctgaag cagcctcact      240

ggagttggga tgcaactatt cctatggtgg aactgttaat ctcttctggt atgtccagta      300

ccctggtcaa caccttcagc ttctcctcaa gtacttttca ggggatccac tggttaaagg      360

catcaagggc tttgaggctg aatttataaa gagtaaattc tcctttaatc tgaggaaacc      420

ctctgtgcag tggagtgaca cagctgagta cttctgtgcc gtgaatgc                   468


<210> 35
<211> 435
<212> DNA
<213> Homo sapiens

<400> 35
atggatacct ggctcgtatg ctgggcaatt tttagtctct tgaaagcagg tcgatgctta       60

gactctagga aattcttgct ttgaacttac ctaagacaat tctaaaccat tctcttaatc      120

ttcttctttt ctcacaggac tcacagaacc tgaagtcacc cagactccca gccatcaggt      180

cacacagatg ggacaggaag tgatcttgcg ctgtgtcccc atctctaatc acttatactt      240

ctattggtac agacaaatct tggggcagaa agtcgagttt ctggtttcct tttataataa      300

tgaaatctca gagaagtctg aaatattcga tgatcaattc tcagttgaaa ggcctgatgg      360

atcaaatttc actctgaaga tccggtccac aaagctggag gactcagcca tgtacttctg      420

tgccagcagt gaagc                                                       435


<210> 36
<211> 460
<212> DNA
<213> Homo sapiens

<400> 36
atgggctgca ggctcctctg ctgtgtggtc ttctgcctcc tccaagcagg tgagtcccgg       60

gcccaggtga catgatccta ttggagtccc taagcctttt caccatgaca acaacagcag      120

gccgtctcct aggatttgcc tgaattctgc ttctttcctt tgcaggtccc ttggacacag      180

ctgtttccca gactccaaaa tacctggtca cacagatggg aaacgacaag tccattaaat      240

gtgaacaaaa tctgggccat gatactatgt attggtataa acaggactct aagaaatttc      300

tgaagataat gtttagctac aataataagg agctcattat aaatgaaaca gttccaaatc      360

gcttctcacc taaatctcca gacaaagctc acttaaatct tcacatcaat tccctggagc      420

ttggtgactc tgctgtgtat ttctgtgcca gcagccaaga                            460


<210> 37
<211> 475
<212> DNA
<213> Homo sapiens

<400> 37
atgggcttca ggctcctctg ctgtgtggcc ttttgtctcc tgggagcagg tgagtcctgg       60

gcacaacttg aaagtctccg atcttcattt cttgtccctg aaatgcatgt gggccaacga      120

tggcttcagc aggaggcttt cttctgtgcc ttatggttaa cttttgtctt ctgacacaca      180

ggcccagtgg attctggagt cacacaaacc ccaaagcacc tgatcacagc aactggacag      240

cgagtgacgc tgagatgctc ccctaggtct ggagacctct ctgtgtactg gtaccaacag      300

agcctggacc agggcctcca gttcctcatt cagtattata atggagaaga gagagcaaaa      360

ggaaacattc ttgaacgatt ctccgcacaa cagttccctg acttgcactc tgaactaaac      420

ctgagctctc tggagctggg ggactcagct ttgtatttct gtgccagcag cgtag           475


<210> 38
<211> 469
<212> DNA
<213> Homo sapiens

<400> 38
atgggtcctg ggcttctcca ctggatggcc ctttgtctcc ttggaacagg tgagtactgg       60

gcagaaagga aatctttgag caaagctatc ttgtcctcag tctgcacctt tcattcacag      120

cagtaacact gttctcctta actctgactc caaatttgtc ttctttctct acaggtcatg      180

gggatgccat ggtcatccag aacccaagat accaggttac ccagtttgga aagccagtga      240

ccctgagttg ttctcagact ttgaaccata acgtcatgta ctggtaccag cagaagtcaa      300

gtcaggcccc aaagctgctg ttccactact atgacaaaga ttttaacaat gaagcagaca      360

cccctgataa cttccaatcc aggaggccga acacttcttt ctgctttctt gacatccgct      420

caccaggcct gggggacaca gccatgtacc tgtgtgccac cagcagaga                  469


<210> 39
<211> 396
<212> DNA
<213> Homo sapiens

<400> 39
atgtggggag ctttccttct ctatgtttcc atgaagatgg gaggcactgc aggacaaagc       60

cttgagcagc cctctgaagt gacagctgtg gaaggagcca ttgtccagat aaactgcacg      120

taccagacat ctgggtttta tgggctgtcc tggtaccagc aacatgatgg cggagcaccc      180

acatttcttt cttacaatgg tctggatggt ttggaggaga caggtcgttt ttcttcattc      240

cttagtcgct ctgatagtta tggttacctc cttctacagg agctccagat gaaagactct      300

gcctcttact tctgcgctgt ttttaaccag gcaggaactg ctctgatctt tgggaaggga      360

accaccttat cagtgagttc caatatccag aaccct                                396


<210> 40
<211> 407
<212> DNA
<213> Homo sapiens

<400> 40
atgctcctgt tgctcatacc agtgctgggg atgatttttg ccctgagaga tgccagagcc       60

cagtctgtga gccagcataa ccaccacgta attctctctg aagcagcctc actggagttg      120

ggatgcaact attcctatgg tggaactgtt aatctcttct ggtatgtcca gtaccctggt      180

caacaccttc agcttctcct caagtacttt tcaggggatc cactggttaa aggcatcaag      240

ggctttgagg ctgaatttat aaagagtaaa ttctccttta atctgaggaa accctctgtg      300

cagtggagtg acacagctga gtacttctgt gccgtgaatg aatacgacta caagctcagc      360

tttggagccg gaaccacagt aactgtaaga gcaaatatcc agaaccc                    407


<210> 41
<211> 417
<212> DNA
<213> Homo sapiens

<400> 41
atgacatcca ttcgagctgt atttatattc ctgtggctgc agctggactt ggtgaatgga       60

gagaatgtgg agcagcatcc ttcaaccctg agtgtccagg agggagacag cgctgttatc      120

aagtgtactt attcagacag tgcctcaaac tacttccctt ggtataagca agaacttgga      180

aaaagacctc agcttattat agacattcgt tcaaatgtgg gcgaaaagaa agaccaacga      240

attgctgtta cattgaacaa gacagccaaa catttctccc tgcacatcac agagacccaa      300

cctgaagact cggctgtcta cttctgtgca gcaaagcgca aggcctctag caacacaggc      360

aaactaatct ttgggcaagg gacaacttta caagtaaaac cagatatcca gaaccct         417


<210> 42
<211> 285
<212> DNA
<213> Homo sapiens

<400> 42
gaacctgaag tcacccagac tcccagccat caggtcacac agatgggaca ggaagtgatc       60

ttgcactgtg tccccatctc taatcactta tacttctatt ggtacagaca aatcttgggg      120

cagaaagtcg agtttctggt ttccttttat aataatgaaa tctcagagaa gtctgaaata      180

ttcgatgatc aattctcagt tgaaaggcct gatggatcaa atttcactct gaagatccgg      240

tccacaaagc tggaggactc agccatgtac ttctgtgcca gcagt                      285


<210> 43
<211> 336
<212> DNA
<213> Homo sapiens

<400> 43
atgggcttca ggctcctctg ctgcgtcgcc ttctgcctcc tccaagcagg tcccttggac       60

acagctgttt cccagactcc aaaatacctg gtcacacaga tgggaaacga caagtccatt      120

aaatgtgaac aaaatctggg ccatgatact atgtattggt ataaacagga ctctaagaaa      180

tttctgaaga taatgtttag ctacaataac aaggagatca ttataaatga aacagttcca      240

aatcgattct cacctaaatc tccagacaaa gctaaattaa atcttcacat caattccctg      300

gagcttggtg actctgctgt gtatttctgt gccagc                                336


<210> 44
<211> 416
<212> DNA
<213> Homo sapiens

<400> 44
accccgacct ctcaacccag gaatcagagc ctgagacaga cagatgcttc attcctgtat       60

ggggtggtat tcctgccatg ggtcctgggc ttctccactg gatggccctt tgtctccttg      120

gaacaggtca tggggatgcc atggtcatcc agaacccaag ataccgggtt acccagtttg      180

gaaagccagt gaccctgagt tgttctcaga ctttgaacca taacgtcatg tactggtacc      240

agcagaagtc aagtcaggcc ccaaagctgc tgttccacta ctataacaaa gattttaaca      300

atgaagcaga cacccctgat aacttccaat ccaggaggcc gaacacttct ttctgctttc      360

tagacatccg ctcaccaggc ctgggggacg cagccatgta ccagtgtgcc accagc          416


<210> 45
<211> 9
<212> PRT
<213> Homo sapiens

<400> 45
Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210> 46
<211> 9
<212> PRT
<213> Homo sapiens

<400> 46
Lys Met Ala Glu Leu Val His Phe Leu 
1               5                   


<210> 47
<211> 9
<212> PRT
<213> Homo sapiens

<400> 47
Lys Met Val Glu Leu Val His Phe Leu 
1               5                   


<210> 48
<211> 9
<212> PRT
<213> Homo sapiens

<400> 48
Lys Val Ala Lys Leu Val His Phe Leu 
1               5                   


<210> 49
<211> 9
<212> PRT
<213> Homo sapiens

<400> 49
Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210> 50
<211> 9
<212> PRT
<213> Homo sapiens

<400> 50
Ile Met Ile Gly Val Leu Val Gly Val 
1               5                   


